Updated on 2024/02/02

写真a

 
NITODA Teruhiko
 
Organization
Faculty of Environmental, Life, Natural Science and Technology Professor
Position
Professor
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Degree

  • Doctor(Agriculture) ( Okayama University )

Research Interests

  • β-N-アセチルグルコサミニダーゼ阻害剤

  • Natural Products Chemistry

  • solid state fermentation

Research Areas

  • Life Science / Bioorganic chemistry

Education

  • Okayama University   農学研究科   生物資源開発学

    - 1992

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    Country: Japan

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  • Okayama University    

    - 1992

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  • Okayama University   農学部   総合農業科学科

    - 1990

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    Country: Japan

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  • Okayama University    

    - 1990

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Research History

  • 岡⼭⼤学⼤学院環境⽣命自然科学研究科   教授

    2023.4

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    Country:Japan

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  • Okayama University   ⼤学院環境⽣命科学研究科   Professor

    2020.4

  • 岡⼭⼤学⼤学院環境⽣命科学研究科 教授

    2020.4 - 2022.3

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  • 岡⼭⼤学⼤学院環境⽣命科学研究科 准教授

    2012.4 - 2020.3

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  • Okayama University   ⼤学院環境⽣命科学研究科   Associate Professor

    2012.4 - 2020.3

  • 岡山大学大学院自然科学研究科 准教授

    2006.10 - 2012.3

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  • Okayama University   The Graduate School of Natural Science and Technology

    2004 - 2006

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  • Okayama University   Advanced Science Research Center

    2003

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  • 岡山大学機器分析センター 助手

    1997 - 2002

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  • Okayama University   Faculty of Agriculture

    1996

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  • 太陽化学(株)総合研究所 研究員

    1992 - 1995

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Professional Memberships

Committee Memberships

  • 日本農薬学会第47回大会実行委員会   実行委員  

    2021 - 2022.3   

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  • 日本農芸化学会2014年度大会 実行委員会   実行委員  

    2014 - 2015.3   

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    Committee type:Academic society

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  • 日本農薬学会第37回大会実行委員会   実行委員  

    2011 - 2012.3   

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Papers

  • New analogs of pochonicine, a potent β-N-acetylglucosaminidase inhibitor from fungus Pochonia suchlasporia var. suchlasporia TAMA 87 Reviewed

    Yuhichi Mushiake, Aya Tsuchida, Asami Yamada, Hiroshi Kanzaki, Toru Okuda, Teruhiko Nitoda

    Journal of Pesticide Science   46 ( 1 )   115 - 119   2021.2

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Pesticide Science Society of Japan  

    Three novel analogs of pochonicine (1) were isolated from a solid fermentation culture of the fungal strain Pochonia suchlasporia var. suchlasporia TAMA 87, and their structures were elucidated as 7-deoxypochonicine (2), 6-deoxypochonicine (3), and 6,7-dideoxypochonicine (4). These analogs were found to possess the same stereochemistry as pochonicine. Comparison of β-N-acetylglucosaminidase (GlcNAcase) inhibitory activity between these analogs and pochonicine suggested that the C-6 hydroxy group of pochonicine was essential to its potent GlcNAcase inhibitory activity and that the C-7 hydroxy group also contributed to the activity, but to a lesser extent than the C-6 hydroxy group.

    DOI: 10.1584/jpestics.d20-086

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  • A new asteltoxin analog with insecticidal activity from Pochonia suchlasporia TAMA 87 Reviewed

    Syaefudin Suminto, Eri Takatsuji, Ayako Iguchi, Hiroshi Kanzaki, Toru Okuda, Teruhiko Nitoda

    Journal of Pesticide Science   45 ( 2 )   81 - 85   2020.5

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Pesticide Science Society of Japan  

    A new asteltoxin analog, named asteltoxin H (1), was isolated by the solid-state fermentation of the fungus Pochonia suchlasporia var. suchlasporia TAMA 87. The chemical structure of 1 was deduced by spectroscopic methods, including 1D and 2D NMR, HRESIMS, and UV-Vis analyses. Compound 1 showed insecticidal activity against prepupae of the blowfly, Lucilia sericata, with an LD50 value of 0.94 µg/mg prepupal body weight.

    DOI: 10.1584/jpestics.d19-081

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  • TMG-chitotriomycin as a probe for the prediction of substrate specificity of β-N-acetylhexosaminidases Reviewed

    Hiroto Shiota, Hiroshi Kanzaki, Tadashi Hatanaka, Teruhiko Nitoda

    Carbohydrate Research   375   29 - 34   2013.6

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.carres.201

  • TMG-chitotriomycin as a probe for the prediction of substrate specificity of β-N-acetylhexosaminidases Reviewed

    Hiroto Shiota, Hiroshi Kanzaki, Tadashi Hatanaka, Teruhiko Nitoda

    Carbohydrate Research   375   29 - 34   2013.6

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.carres.2013.04.024

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  • Pochonicine, a polyhydroxylated pyrrolizidine alkaloid from fungus Pochonia suchlasporia var. suchlasporia TAMA 87 as a potent β-N-acetylglucosaminidase inhibitor Reviewed

    Hirokazu Usuki,Miho Toyo-oka, Hiroshi Kanzaki, Toru Okuda and *Teruhiko Nitoda,

    Bioorganic & Medicinal Chemistry   17 ( 20 )   7248 - 7253   2009.10

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  • Pochonicine, a polyhydroxylated pyrrolizidine alkaloid from fungus Pochonia suchlasporia var. suchlasporia TAMA 87 as a potent beta-N-acetylglucosaminidase inhibitor Reviewed

    Hirokazu Usuki, Miho Toyo-oka, Hiroshi Kanzaki, Toru Okuda, Teruhiko Nitoda

    BIOORGANIC & MEDICINAL CHEMISTRY   17 ( 20 )   7248 - 7253   2009.10

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:PERGAMON-ELSEVIER SCIENCE LTD  

    A new polyhydroxylated pyrrolizidine alkaloid designated as pochonicine (1) was isolated from a solid fermentation culture of the fungal strain Pochonia suchlasporia var. suchlasporia TAMA 87. The structure of 1 was determined using NMR and MS techniques as (1R*, 3S*, 5S*, 6S*, 7R*, 7a S*)-5-acetamidomethyl-3-hydroxymethyl-1,6,7-trihydroxypyrrolizidine. Pochonicine (1) showed potent inhibition against beta-N-acetylglucosaminidases (GlcNAcases) of various organisms including insects, fungi, mammals, and a plant but no inhibition against beta-glucosidase of almond, alpha-glucosidase of yeast, or chitinase of Bacillus sp. The GlcNAcase inhibitory activity of pochonicine (1) was comparable to nagstatin, a potent GlcNAcase inhibitor of natural origin. (C) 2009 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.bmc.2009.08.052

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  • TMG-chitotriomycin, an Enzyme Inhibitor Specific for Insect and Fungal β-N-Acetylglucosaminidases, Produced by Actinomycete Streptomyces anulatus NBRC 13369 Reviewed International journal

    Hirokazu Usuki, Teruhiko Nitoda, Misato Ichikawa, Nahoko Yamaji, Takashi Iwashita, Hajime Komura, Hiroshi Kanzaki

    Journal of the American Chemical Society   130 ( 12 )   4146 - 4152   2008.3

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    A novel beta-N-acetylglucosaminidase (GlcNAcase) inhibitor named TMG-chitotriomycin (1) was isolated from the culture filtrate of Streptomyces anulatus NBRC13369. The strain produced 1 only when colloidal chitin was used as the sole carbon source in the production medium. The structure of 1 was determined by spectral and constitutive sugar analyses of the corresponding alditol derivatives to be an equilibrated mixture of alpha-d-N,N,N-triMeGlcNH2-(1,4)-beta-d-GlcNAc-(1,4)-beta-d-GlcNAc-(1,4)-d-GlcNAc and its C-2 epimer of the reducing end residue. TMG-chitotriomycin (1) showed potent and selective inhibition of insect and fungal GlcNAcases with no inhibition of mammalian and plant GlcNAcases. In contrast, the known GlcNAcase inhibitor nagstatin potently inhibited all GlcNAcases. It should be emphasized that synthesized d-N,N,N-triMeGlcNH2, which is the component sugar of 1, showed no inhibition of the insect Spodoptera litura GlcNAcase. These results suggest that the (GlcNAc)3 unit positioned at the reducing end of 1 is essential for its enzyme inhibitory activity. The unique inhibitory spectrum of 1 will be useful to study chitinolytic systems and to develop selective fungicides or pesticides.

    DOI: 10.1021/ja077641f

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  • TMG-chitotriomycin, an enzyme inhibitor specific for insect and fungal beta-N-acetylglucosaminidases, produced by actinomycete Streptomyces anulatus NBRC 13369 Reviewed

    Hirokazu Usuki, Teruhiko Nitoda, Misato Ichikawa, Nahoko Yamaji, Takashi Iwashita, Hajime Komura, Hiroshi Kanzaki

    Journal of the American Chemical Society   130 ( 12 )   4146 - 4152   2008.2

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    DOI: 10.1021/ja077641f

  • Potential of lactic acid bacteria to produce functional fermented whey beverage with putative health promoting attributes Reviewed

    Jirayu Jitpakdee, Duangporn Kantachote, Hiroshi Kanzaki, Teruhiko Nitoda

    LWT   160   113269 - 113269   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.lwt.2022.113269

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  • Aerobic bioconversion of C-glycoside mangiferin into its aglycone norathyriol by an isolated mouse intestinal bacterium Reviewed International journal

    Uswatun Hasanah, Kasumi Miki, Teruhiko Nitoda, Hiroshi Kanzaki

    Bioscience, Biotechnology, and Biochemistry   85 ( 4 )   989 - 997   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Oxford University Press (OUP)  

    <title>ABSTRACT</title>
    Norathyriol is an aglycone of a xanthonoid C-glycoside mangiferin that possesses different bioactive properties useful for humans compared to mangiferin. Mangiferin is more readily available in nature than norathyriol; thus, efficient mangiferin conversion into norathyriol is desirable. There are a few reports regarding mangiferin C-deglycosylation because of the C–C bond resistance toward acid, alkaline, and enzyme hydrolysis. In this study, we isolated a mangiferin-deglycosylating bacterium strain KM7-1 from the mouse intestine. 16S rDNA sequencing indicated that KM7-1 belongs to the Bacillus genus. Compared to the taxonomically similar bacteria, the growth characteristic of facultative anaerobic and thermophilic resembled, yet only Bacillus sp. KM7-1 was able to convert mangiferin into norathyriol. Resting cells of Bacillus sp. KM7-1 obtained from aerobic cultivation at 50 °C showed high norathyriol formation from 1 m m of mangiferin. Norathyriol formation can be conducted either under aerobic or anaerobic conditions, and the reaction depended on time and bacterial amount.

    DOI: 10.1093/bbb/zbaa121

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    Other Link: http://academic.oup.com/bbb/article-pdf/85/4/989/36682540/zbaa121.pdf

  • Aerobic bioconversion of C-glycoside mangiferin into its aglycone norathyriol by an isolated mouse intestinal bacterium Reviewed

    Uswatun Hasanah, Kasumi Miki, Teruhiko Nitoda, Hiroshi Kanzaki

    Bioscience, Biotechnology, and Biochemistry   85 ( 4 )   989 - 997   2021.1

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  • Selected probiotic lactic acid bacteria isolated from fermented foods for functional milk production: Lower cholesterol with more beneficial compounds Reviewed

    Jirayu Jitpakdee, Duangporn Kantachote, Hiroshi Kanzaki, Teruhiko Nitoda

    LWT   135   110061 - 110061   2021.1

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    DOI: 10.1016/j.lwt.2020.110061

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  • In vitro and in vivo selection of probiotic purple nonsulphur bacteria with an ability to inhibit shrimp pathogens: acute hepatopancreatic necrosis disease-causing Vibrio parahaemolyticus and other vibrios Reviewed

    Supaporn Chumpol, Duangporn Kantachote, Pattamarat Rattanachuay, Varaporn Vuddhakul, Teruhiko Nitoda, Hiroshi Kanzaki

    Aquaculture Research   48 ( 6 )   3182 - 3197   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Blackwell Publishing Ltd  

    Shrimp cultivation has been faced with huge losses in productivity caused by infectious shrimp pathogenic vibrios, especially Vibrio parahaemolyticus that causes acute hepatopancreatic necrosis disease (AHPND). Hence, purple nonsulphur bacteria (PNSB) were isolated from shrimp ponds for investigating their abilities to control shrimp pathogenic Vibrio spp. and their use as probiotics for sustainable shrimp cultivation. Based on their probiotic properties, strains S3W10 and SS15 were selected because of their strong abilities to produce amylase, gelatinase and vitamin B12. However, only three PNSB strains (SS15, TKW17 and STW181) strongly inhibited V. harveyi_KSAAHRC and V. vulnificus_KSAAHRC including V. parahaemolyticusAHPND strains by secreting antivibrio compounds. Four selected PNSB also grew in the presence of pancreatic enzymes, and they were identified as Rhodobacter sphaeroides for strains S3W10, SS15 and TKW17 and Afifella marina for strain STW181. The effects of a mixed culture were also investigated as follows: T1 (S3W10 + SS15), T2 (S3W10 + TKW17) and T3 (S3W10 + STW181) on postlarval white shrimp (Litopenaeus vannamei) for 60 days by comparison with a control. All three probiotic PNSB sets significantly improved the digestive enzyme activities and shrimp growth with their proliferation in shrimp gastrointestinal tract although the shrimp survival was not significantly different. They also significantly reduced the cumulative mortality of shrimp exposed to a virulent AHPND strain (V. parahaemolyticusSR2). This is the first to conclude that selected probiotic PNSB strains have great potential to be used for shrimp cultivation to control vibrios including AHPND strains.

    DOI: 10.1111/are.13149

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  • The roles of probiotic purple nonsulfur bacteria to control water quality and prevent acute hepatopancreatic necrosis disease (AHPND) for enhancement growth with higher survival in white shrimp (Litopenaeus vannamei) during cultivation Reviewed

    Supaporn Chumpol, Duangporn Kantachote, Teruhiko Nitoda, Hiroshi Kanzaki

    AQUACULTURE   473   327 - 336   2017.4

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    This study aimed to investigate the potential of a mixed probiotic purple nonsulfur bacteria (PNSB) for controlling water quality and preventing acute hepatopancreatic necrosis disease (AHPND) to promote growth performance and increase survival of white shrimp (Litopenaeus vannamei) in postlarval stage during cultivation. Four probiotic PNSB (Rhodobacter sphaeroides strains SS15, S3W10, TKW17 and Afifella marina STW181) were investigated for controlling water quality using a mixed culture at a ratio of 1: 1 (roughly 1 x 10(8) cells mL(-1) for each, every week 1-7) as follows; T1 (S3W10 + SS15), T2 (S3W10 + TKW17) and T3 (S3W10 + STW181) and found that throughout 8 weeks shrimp cultivation the most effective sets to reduce NH4(+) and promote shrimp growth (based on weight and total length) were T1 and T3, respectively. Hence, PNSB strains (SS15, S3W10 and STW181) were used as a mixed culture (1: 1: 1, roughly 1 x 10(8) cells mL(-1) for each at weeks 1, 2 and 3) assessing their potential to prevent AHPND by challenge test on shrimp with a virulent strain AHPND-causing Vibrio parahaemolyticus SR2 (roughly 1 x 10(5) cells mL(-1) at day 15) during shrimp cultivation for 30 days. Inoculated PNSB sets (positive control: only PNSB inoculation, and treatment: both PNSB and SR2 inoculations) significantly decreased (P &lt; 0.05) the levels of NH4-, NO2-, NO3- and chemical oxygen demand (COD) with significantly higher (P &lt; 0.05) of dissolved oxygen (DO) compared to native control (no inoculation) and challenge test (only SR2 inoculation). The maximal growth performance of shrimp was observed in the positive control; while no significant difference (P &gt; 0.05) was observed for other sets. PNSB survived and colonized in intestinal shrimp tract to prevent AHPND by increasing 11% survival rate of infected shrimp by strain SR2. The correlation coefficient between PNSB population and shrimp survival showed a positive strong correlation, but a negative strong correlation between vibrios population and shrimp survival. Overall results proved that a mixed three probiotic PNSB are a good candidate for applying in white shrimp cultivation to maintain water quality and to protect shrimp diseases for promoting shrimp growth with higher survival rate. (C) 2017 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.aquaculture.2017.02.033

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  • Selection of salt tolerant purple nonsulfur bacteria producing 5-aminolevulinic acid (ALA) and reducing methane emissions from microbial rice straw degradation Reviewed

    Tomorn Nunkaew, Duangporn Kantachote, Teruhiko Nitoda, Hiroshi Kanzaki

    APPLIED SOIL ECOLOGY   86   113 - 120   2015.2

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    Saline soil is one major problem that causes low productivity on rice, while paddy fields are also one source of methane (CH4) emissions that can have a considerable impact on global warming. By using purple nonsulfur bacteria (PNSB) it is possible to overcome both these serious problems because PNSB produce 5-aminolevulinic acid (ALA), a compound that reduces salt stress for plants, and they are also good competitors for methanogens in the paddy fields. Therefore, the objective of this study was to select salt resistant PNSB with an ability to release ALA and reduce CH4 emissions. The PNSB isolates used were obtained from saline paddy fields in southern Thailand and the best were selected on the basis of their good growth under conditions of aerobic dark and anaerobic light while being salt tolerant, released ALA and reduced CH4 emissions under microaerobic light conditions. Among the 272 PNSB isolates, TN114 was the best ALA producer while PP803 was the best to reduce CH4 emissions. Both selected PNSB strains grew well in glutamate acetate (GA) broth containing NaCl up to 6.00% but 0.25% NaCl was their optimal concentration for growth. Under salt stress with 0.25% NaCl, the strain TN114 released 25.63 mu M ALA in GA broth. In scaled-up experiments, when it was mixed with native soil flora in rice straw broth the strain TN114 released 13.44 mu M ALA and the strain PP803 reduced CH4 emissions by 88.41%. These two strains were identified as Rhodopseudomonas palustris according to both traditional and 16 S rRNA identifications. Overall the results demonstrated that they had a good potential as plant growth stimulating bacteria under salt stress, due to the release of ALA and also reduce CH4 emissions. (C) 2014 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.apsoil.2014.10.005

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  • Characterization of exopolymeric substances from selected Rhodopseudomonas palustris strains and their ability to adsorb sodium ions Reviewed

    Tomorn Nunkaew, Duangporn Kantachote, Teruhiko Nitoda, Hiroshi Kanzaki, Raymo, J. Ritchie

    Carbohydrate Polymers   115 ( 22 )   334 - 341   2015.1

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    DOI: 10.1016/j.carbpol.20

  • Characterization of exopolymeric substances from selected Rhodopseudomonas palustris strains and their ability to adsorb sodium ions Reviewed

    Tomorn Nunkaew, Duangporn Kantachote, Teruhiko Nitoda, Hiroshi Kanzaki, Raymond J. Ritchie

    Carbohydrate Polymers   115   334 - 341   2015.1

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    DOI: 10.1016/j.carbpol.2014.08.099

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  • Effects of 5-aminolevulinic acid (ALA)-containing supernatants from selected Rhodopseudomonas palustris strains on rice growth under NaCl stress, with mediating effects on chlorophyll, photosynthetic electron transport and antioxidative enzymes Reviewed

    Tomorn Nunkaew, Duangporn Kantachote, Hiroshi Kanzaki, Teruhiko Nitoda, Raymond J. Ritchie

    ELECTRONIC JOURNAL OF BIOTECHNOLOGY   17 ( 1 )   19 - 26   2014.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:UNIV CATOLICA DE VALPARAISO  

    Background: Rice is globally one of the most important food crops, and NaCl stress is a key factor reducing rice yield. Amelioration of NaCl stress was assessed by determining the growth of rice seedlings treated with culture supernatants containing 5-aminolevulinic acid (ALA) secreted by strains of Rhodopseudomonas palustris (TN114 and PP803) and compared to the effects of synthetic ALA (positive control) and no ALA content (negative control).
    Results: The relative root growth of rice seedlings was determined under NaCl stress (50 mM NaCl), after 21 d of pretreatment. Pretreatments with 1 mu M commercial ALA and 10X diluted culture supernatant of strain TN114 (2.57 mu M ALA) gave significantly better growth than 10X diluted PP803 supernatant (2.11 mu M ALA). Rice growth measured by dry weight under NaCl stress ordered the pretreatments as: commercial ALA N TN114 N PP803 N negative control. NaCl stress strongly decreased total chlorophyll of the plants that correlated with non-photochemical quenching of fluorescence (NPQ). The salt stress also strongly increased hydrogen peroxide (H2O2) concentration in NaCl-stressed plants. The pretreatments were ordered by reduction in H2O2 content underNaCl stress as: commercial ALA N TN114 N PP803 N negative control. The ALA pretreatments incurred remarkable increases of total chlorophyll and antioxidative activities of catalase (CAT), ascorbate peroxide (APx), glutathione reductase (GR) and superoxide dismutase (SOD); under NaCl stress commercial ALA and TN114 had generally stronger effects than PP803.
    Conclusions: The strain TN114 has potential as a plant growth stimulating bacterium that might enhance rice growth in saline paddy fields at a lower cost than commercial ALA. (C) 2014 Pontificia Universidad Catolica de Valparaiso. Production and hosting by Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.ejbt.2013.12.004

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  • Synthesis of Eight Stereoisomers of Pochonicine: Nanomolar Inhibition of β-N-Acetylhexosaminidases. Reviewed

    Zhu JS., Nakagawa S., Chen W., Adachi I., Jia YM., Hu, X-G., Fleet GW., Wilson, FX., Nitoda T., Horne G., van Well R., Kato A., Yu CY.

    Journal of Organic Chemistry   78 ( 20 )   10298-10309   2013.9

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    DOI: 10.1021/jo401694e

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  • Total synthesis of the proposed structure for pochonicine and determination of its absolute configuration Reviewed

    Kitamura Y, Koshino H, Nakamura T, Tsuchida A, Nitoda T, Kanzaki H, Matsuoka K, Takahashi S

    Tetrahedron Letters   54 ( 11 )   1456 - 1459   2013

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:PERGAMON-ELSEVIER SCIENCE LTD  

    Pochonicine is a polyhydroxylated pyrrolizidine alkaloid with a powerful inhibitory activity against beta-N-acetylglucosaminidases. The proposed structure for pochonicine and the three diastereomers concerning its C-1 and/or C-3 positions were synthesized from N-acetyl-D-glucosamine through construction of the pyrrolizidine skeleton by two intramolecular amino cyclizations as key steps. This synthetic study not only revised the structure of the natural product to the corresponding 1,3-di-epi-form but also determined the absolute configuration as 1R, 3S, 5R, 6R, 7S, 7aR. (C) 2013 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.tetlet2013.01.015

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  • The use of rice straw broth as an appropriate medium to isolate purple nonsulfur bacteria from paddy fields Reviewed

    Tomorn Nunkaew, Duangporn Kantachote, Teruhiko Nitoda, Hiroshi Kanzaki

    ELECTRONIC JOURNAL OF BIOTECHNOLOGY   15 ( 6 )   2012.11

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:UNIV CATOLICA DE VALPARAISO  

    The aims were to explore an appropriate isolating medium for obtaining purple nonsulfur bacteria (PNSB) for use as biofertilizers in saline paddy fields and to obtain pure cultures. We therefore chose a defined isolating medium containing 0.25% NaCl, (Glutamate-Acetate broth, GA) and a rice straw broth to compare them for numbers of PNSB obtained, time to obtain pure cultures, diversity and costs. A total of 30 water and 30 sediment samples were collected from saline paddy fields in southern Thailand and used to isolate PNSB in both the isolating media. Based on 60 samples and a period of 13 days incubation under anaerobic light conditions, a greater number of samples produced PNSB growth in GA broth after only day 3; however, after that the rice straw broth provided about a 2 fold increase in the number of samples that produced PNSB growth. Colonies isolated from GA broth required a significantly higher number of repeated streaking to obtain a pure culture (average 3.5) than those from rice straw broth (average 2.7) and the latter medium also produced significantly (P &lt; 0.05) more isolates per sample. Sixty samples of water and sediment, from rice paddies with salinity (average, 3.43 +/- 0.67 mS/cm) and slight acidity (average, pH 5.84 +/- 0.42) provided 62 PNSB isolates by GA broth and 210 isolates by rice straw broth, and rice straw broth also produced a greater prevalence of PNSB. Estimates of the costs based on current prices of media, Gas Pak and electricity to obtain PNSB with the use of GA broth was roughly 6 times higher than for the rice straw broth.

    DOI: 10.2225/vol15-issue6-fulltext-8

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  • Melanogenesis inhibitors from Rabdosia japonica Reviewed

    Hiroki Satooka, Takahiko Isobe, Teruhiko Nitoda, Isao Kubo

    Phytomedicine   19 ( 11 )   1016 - 1023   2012.8

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    The effects of the four major ent-kaurene diterpenoids isolated from the aerial part of Rabdosia japonica (Labiatae) on murine B16-F10 melanoma cells were investigated. Among the compounds tested, oridonin and nodosin most significantly suppressed cellular melanin production when the cells were cultured with these diterpenoids. However, oridonin and nodosin exhibited cytotoxicity against the same melanoma cells with an IC50 of 1.1 μM (0.40 μg/ml) and of 1.3 μM (0.47 μg/ml) and almost complete lethality was observed at 4.0 μM and at 8.0 μM, respectively, and therefore observed melanogenesis inhibition is mainly due to its melanocytotoxic effect. Morphological observation showed that oridonin or nodosin treated B16-F10 melanoma cells induced dendrite structure. Diterpenoids quickly formed adducts partly in Dulbecco's Modified Eagle's Medium (DMEM) containing 10% of fetal bovine serum (10% FBS-DMEM) before their application to the cells. Approximately 20% of oridonin formed adducts within the first 15 min. Notably, dihydronodosin exhibited inferior cytotoxicity (&gt
    85% cell viability at 100 μM) but still significantly suppressed melanogenesis (&gt
    55%) when murine B16-F10 melanoma cells were cultured with this diterpenoid derivatives. Hence, dihydronodosin can be a potential melanogenesis inhibitor. © 2012 Elsevier GmbH. All rights reserved.

    DOI: 10.1016/j.phymed.2012.05.007

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  • Peptide bond formation by aminolysin-A catalysis: A simple approach to enzymatic synthesis of diverse short oligopeptides and biologically active puromycins Reviewed

    Hirokazu Usuki, Yukihiro Yamamoto, Jiro Arima, Masaki Iwabuchi, Shozo Miyoshi, Teruhiko Nitoda, Tadashi Hatanaka

    Organic and Biomolecular Chemistry   9 ( 7 )   2327 - 2335   2011.4

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    A new S9 family aminopeptidase derived from the actinobacterial thermophile Acidothermus cellulolyticus was cloned and engineered into a transaminopeptidase by site-directed mutagenesis of catalytic Ser491 into Cys. The engineered biocatalyst, designated aminolysin-A, can catalyze the formation of peptide bonds to give linear homo-oligopeptides, hetero-dipeptides, and cyclic dipeptides using cost-effective substrates in a one-pot reaction. Aminolysin-A can recognize several C-terminal-modified amino acids, including the l- and d-forms, as acyl donors as well as free amines, including amino acids and puromycin aminonucleoside, as acyl acceptors. The absence of amino acid esters prevents the formation of peptides
    therefore, the reaction mechanism involves aminolysis and not a reverse reaction of hydrolysis. The aminolysin system will be a beneficial tool for the preparation of structurally diverse peptide mimetics by a simple approach. © 2011 The Royal Society of Chemistry.

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  • Antivibrio compounds produced by Pseudomonas sp W3: characterisation and assessment of their safety to shrimps Reviewed

    Pattamarat Rattanachuay, Duangporn Kantachote, Manee Tantirungkij, Teruhiko Nitoda, Hiroshi Kanzaki

    WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY   27 ( 4 )   869 - 880   2011.4

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    In order to explore compounds naturallly inhibitory to shrimp pathogenic vibrios, a culture filtrate of Pseudomonas sp. W3 at a pH of 2 was extracted with ethyl acetate (EtOAc) to produce 82.15 mg/l of a yellow-brown extract (EtOAc-W3) that had MIC values of 225-450 mu g/ml against the growth of 18 shrimp pathogenic Vibrio harveyi strains. The MIC of EtOAc-W3 against the most pathogenic strain PSU 2015 was 450 mu g/ml and this strain had the lowest LD(50) (50% lethal dose) to pacific white shrimp (Litopenaeus vannamei, PL 21). At this MIC value, EtOAc-W3 in artificial sea water (ASW) killed strain PSU 2015; however in natural sea water, only a partial growth inhibition was observed. The toxicity to pacific white shrimp and antivibrio activity of the EtOAc-W3 were investigated by conducting an experiment with 4 sets; native control (commercial ASW), EtOAc-W3 control (MIC/10, 45 mu g/ml), challenge (inoculation 6.0 x 10(6) c.f.u./ml PSU 2015) and treatment (6.0 x 10(6) c.f.u./ml PSU 2015 + 45 mu g/ml EtOAc-W3). The same experiment was repeated by increasing the dose of EtOAc-W3 to 90 mu g/ml (MIC/5). Both concentrations of EtOAc-W3 tested had no toxicity to postlarval shrimps. A significant decrease in shrimp mortality was observed over a 72 h period as approximately 80% of the shrimps died in each challenge set but only 63 and 23% died in the presence of 45 and 90 mu g/ml EtOAc-W3. The major component of EtOAc-W3 was supposed to be 2-heptyl-4-quinolone (HHQ) by FAB-MS and (1)H-NMR analyses of the purified fraction.

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  • Multifunctional Cytotoxic Agents from Anacardium occidentale Reviewed

    Isao Kubo, Teruhiko Nitoda, Felismino E. Tocoli, Ivan R. Green

    PHYTOTHERAPY RESEARCH   25 ( 1 )   38 - 45   2011.1

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  • MS/MS fragmentation-guided search of TMG-chitooligomycins and their structure-activity relationship in specific beta-N-acetylglucosaminidase inhibition Reviewed

    Hirokazu Usuki, Yukihiro Yamamoto, Yuya Kumagai, Teruhiko Nitoda, Hiroshi Kanzaki, Tadashi Hatanaka

    ORGANIC & BIOMOLECULAR CHEMISTRY   9 ( 8 )   2943 - 2951   2011

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    The reducing tetrasaccharide TMG-chitotriomycin (1) is an inhibitor of beta-N-acetylglucosaminidase (GlcNAcase), produced by the actinomycete Streptomyces anulatus NBRC13369. The inhibitor shows a unique inhibitory spectrum, that is, selectivity toward enzymes from chitin-containing organisms such as insects and fungi. Nevertheless, its structure-selectivity relationship remains to be clarified. In this study, we conducted a structure-guided search of analogues of 1 in order to obtain diverse N,N,N-trimethylglucosaminium (TMG)-containing chitooligosaccharides. In this approach, the specific fragmentation profile of 1 on ESI-MS/MS analysis was used for the selective detection of desired compounds. As a result, two new analogues, named TMG-chitomonomycin (3) and TMG-chitobiomycin (2), were obtained from a culture filtrate of 1-producing Streptomyces. Their enzyme-inhibiting activity revealed that the potency and selectivity depended on the degree of polymerization of the reducing end GlcNAc units. Furthermore, a computational modeling study inspired the inhibitory mechanism of TMG-related compounds as a mimic of the substrate in the Michaelis complex of the GH20 enzyme. This study is an example of the successful application of a MS/MS experiment for structure-guided isolation of natural products.

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  • Characterization of the antiyeast compound and probiotic properties of a starter Lactobacillus plantarum DW3 for possible use in fermented plant beverages International coauthorship

    Duangporn Kantachote, Pakorn, Prachyakij, Wilawan Charernjiratrakul, Metta Ongsakul, Yodsawee Duangjitcharoen, Chaiyavat Chaiyasut, Teruhiko Nitoda, Hiroshi Kanzaki

    Electronic Journal of Biotechnology   13 ( 5 )   2010.9

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  • Characterization of the antiyeast compound and probiotic properties of a starter Lactobacillus plantarum DW3 for possible use in fermented plant beverages Reviewed

    Duangporn Kantachote, Pakorn Prachyakij, Wilawan Charernjiratrakul, Metta Ongsakul, Yodsawee Duangjitcharoen, Chaiyavat Chaiyasut, Teruhiko Nitoda, Hiroshi Kanzaki

    Electronic Journal of Biotechnology   13 ( 5 )   2010.9

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  • Inhibition of shrimp pathogenic vibrios by extracellular compounds from a proteolytic bacterium Pseudomonas sp. W3 International coauthorship

    Pattamarat Rattanachuay, Duangporn Kantachote, Manee Tantirungkij, Teruhiko Nitoda, Hiroshi Kanzaki

    Electronic Journal of Biotechnology   13 ( 1 )   2010.1

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    DOI: 10.2225/vol13-issue1

  • Inhibition of shrimp pathogenic vibrios by extracellular compounds from a proteolytic bacterium Pseudomonas sp. W3 Reviewed

    Duangporn Kantachote, Pattamarat Rattanachuay, Manee Tantirungkij, Teruhiko Nitoda, Hiroshi Kanzaki

    Electronic Journal of Biotechnology   13 ( 1 )   2010.1

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  • Erratum to "Chemical structures and biological activities of rhamnolipids produced by Pseudomonas aeruginosa B189 isolated from milk factory waste" [Bioresour. Technol. 98(5) (2007) 1149-1153] (DOI:10.1016/j.biortech.2005.10.045) Reviewed

    Benjamas Thanomsub, Wanna Pumeechockchai, Anirut Limtrakul, Panarat Arunrattiyakorn, Wipawan Petchleelaha, Teruhiko Nitoda, Hiroshi Kanzaki

    Bioresource Technology   100 ( 23 )   6141   2009.12

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    DOI: 10.1016/j.biortech.2009.04.058

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  • Effects of phenolic compounds isolated from Rabdosia japonica on B16-F10 melanoma cells Reviewed

    *Teruhiko Nitoda, Takahiko Isobe, Isao Kubo

    Phytotherapy Research   22 ( 7 )   867 - 872   2008.7

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  • Effects of cuminaldehyde on melanoma cells Reviewed

    *Teruhiko Nitoda, Maria D. Fan, Isao Kubo

    Phytotherapy Research   22 ( 6 )   809 - 813   2008.6

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  • Antinematodal activities of ingenane diterpenes from Euphorbia kansui and their derivatives against the pine wood nematode (Bursaphelenchus xylophilus) Reviewed

    Shi Jianxiao, Li Zhixuan, Nitoda Teruhiko, Izumi Minoru, Kanzaki Hiroshi, Baba Naomichi, Kawazu Kazuyoshi, Nakajima Shuhei

    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES   63 ( 1-2 )   59 - 65   2008

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  • Purification and characterization of a biosurfactant produced by Issatchenkia orientalis SR4 Reviewed International coauthorship

    Katemai, Wichuda, Maneerat, Suppasil, Kawai, Fusako, Kanzaki, Hiroshi, Nitoda, Teruhiko, H-Kittikun, Aran

    Journal of General and Applied Microbiology   36 ( 2 )   79 - 82   2008

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  • Antinematodal activities of ingenane diterpenes from Euphorbia kansui and their derivatives against the pine wood nematode (Bursaphelenchus xylophilus) Reviewed

    Jianxiao Shi, Zhixuan Li, Teruhiko Nitoda, Minoru Izumi, Hiroshi Kanzaki, Naomichi Baba, Kazuyoshi Kawazu, Shuhei Nakajima

    Zeitschrift fur Naturforschung - Section C Journal of Biosciences   63 ( 1-2 )   59 - 65   2008

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    Under the bioassay-guided method, two diterpenes, 3-O-(2″,3″- dimethylbutanoyl)-13-O-dodecanoylingenol (1) and 3-O-(2″,3″- dimethylbutanoyl)-13-O-decanoylingenol (2) isolated from Euphorbia kansui, showed a pronounced antinematodal activity against the nematode Bursaphelenchus xylophilus at the same minimum effective dose (MED) of 5 μg per cotton ball and still displayed antinematodal activity at a dose of 2.5 μg per cotton ball. Compounds 3-6 were obtained, and the structure of the new compound 6 was elucidated based on 1D-and 2D-NMR analyses and physicochemical data. Preliminary structure-biological activity relationships of ingenane-type compounds were deduced. © 2008 Verlag der Zeitschrift für Naturforschung.

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  • Purification and characterization of a biosurfactant produced by Issatchenkia orientalis SR4 Reviewed

    Wichuda Katemai, Suppasil Maneerat, Fusako Kawai, Hiroshi Kanzaki, Teruhiko Nitoda, Aran H-Kittikun

    The Journal of General and Applied Microbiology   54 ( 1 )   79 - 82   2008

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  • Repellent from traditional chinese medicine, Periploca sepium Bunge Reviewed

    Jianxiao Shi, Tomoko Yamashita, Ayumi Todo, Teruhiko Nitoda, Minoru Izumi, Naomichi Baba, Shuhei Nakajima

    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES   62 ( 11-12 )   821 - 825   2007.11

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    By using a new bioassay-guided method, 2-hydroxy-4-methoxybenzaldehyde isolated from the root bark of Periploca sepium, a traditional Chinese medicine, showed repellent activity against the olive weevil (Dyscerus perforatus) at 62.5, 125, 250 and 500 mu g/disc, respectively. In addition, it also exhibited antinematodal activity against Bursaphelenchus xylophilus at a minimum effective dose of 200 mu g/ball. The three related compounds obtained were also evaluated for the above-mentioned bioactivities.

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  • Effects of Quercetin on Mushroom Tyrosinase and B16-F10 Melanoma Cells Reviewed

    Isao Kubo, *Teruhiko Nitoda and Ken-ichi Nihei

    Molecules   12 ( 5 )   1045 - 1056   2007.5

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  • Three Antinematodal Diterpenes from Euphorbia kansui. Reviewed

    Shi, J.-X, Li, Z.-X, Nitoda, T, Izumi, M, Kanzaki, H, Baba, N, Kawazu, K, Nakajima, S

    Bioscience, Biotechnology, and Biochemistry   71 ( 4 )   1086 - 1089   2007.4

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  • Effect of Salicylic acid in Mushroom Tyrosinase and B16 Melanoma Cells Reviewed

    S. Tamura, *T. Nitoda and I. Kubo

    Zeitschrift fur Naturforschung C   62c, 227-233 (2007)   2007.4

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  • Three antinematodal diterpenes from Euphorbia kansui Reviewed

    Jian-Xiao Shi, Zhi-Xuan Li, Teruhiko Nitoda, Minoru Izumi, Hiroshi Kanzaki, Naomichi Baba, Kazuyoshi Kawazu, Shuhei Nakajima

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   71 ( 4 )   1086 - 1089   2007.4

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    Three compounds, 20-O-acetyl-[3-O-(2'E,4'Z)-deca-dienoyl]-ingenol (1), 20-O-acetyl-[5-O-(2'E,4'Z)-decadienoyl]-ingenol (2) and 3-O-(2'E,4'Z)-decadienoylingenol (3), were isolated from Euphorbia kansui under the bioassay-guided method. Each compound showed the same antinematodal activity against the nematode, Bursaphelenchus xylophilus, at a minimum effective dose (MED) of 5 mu g/cotton ball.

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  • Enzymatic Synthesis of Dehydroderivatives from Proline-Containing Cyclic Dipeptides and Their Effects toward Cell Division Reviewed

    Panarat ARUNRATTIYAKORN, Banri IKEDA, Teruhiko NITODA, Hiroshi KANZAKI

    Bioscience, Biotechnology and Biochemistry   71 ( 3 )   830 - 833   2007.3

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  • Enzymatic Synthesis of Dehydroderivatives from Proline-Containing Cyclic Dipeptides and Their Effects toward Cell Division Reviewed

    Panarat ARUNRATTIYAKORN, Banri IKEDA, Teruhiko NITODA, Hiroshi KANZAKI

    Bioscience, Biotechnology, and Biochemistry   71 ( 3 )   830 - 833   2007.3

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    We have previously isolated cyclo(<small>L</small>-Pro-<small>L</small>-Tyr) and cyclo(<small>L</small>-Phe-<small>L</small>-Pro) from an actinomycete by a novel enzymatic conversion-guided method. Their tetradehydro derivatives, cyclo(ΔPro-ΔTyr) and cyclo(ΔPhe-ΔPro), were enzymatically prepared. Neither of them inhibited cell division, in contrast to other tetradehydro cyclic dipeptides prepared previously. This result suggests that an NH proton in a diketopiperazine ring and/or conformation of the compound are important for the activity.

    DOI: 10.1271/bbb.60651

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  • Chemical structures and biological activities of rhamnolipids produced by Pseudomonas aeruginosa B189 isolated from milk factory waste (Retracted Article. See vol 100, pg 6141, 2009) Reviewed

    Benjamas Thanomsub, Wanna Pumeechockchai, Anirut Limtrakul, Panarat Arunrattiyakorn, Wipawan Petchleelaha, Teruhiko Nitoda, Hiroshi Kanzaki

    BIORESOURCE TECHNOLOGY   98 ( 5 )   1149 - 1153   2007.3

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    The aim of this work was to study chemical structures and biological activities of rhamnolipids produced by Pseudomonas aeruginosa B189 isolated from milk factory waste. The culture produced two biosurfactants, a and b, which showed strong activity and were identified as L-rhamnopyranosyl-(L)-rhamnopyranosyl-beta-hydroxydecanoyl-beta-hydroxydecanoate or Rha-Rha-C-10-C-10 and (L)-rhamnopyranosyl-(L)-rhamnopyranosyl-beta-hydroxydecanoyl-beta-hydroxydodecanoate or Rha-Rha-C-10-C-12, respectively. Both compounds exhibited higher surfactant activities tested by the drop collapse test than several artificial surfactants such as SDS and Tween 80. Rhamnolipid a showed significant antiproliferative activity against human breast cancer cell line (MCF-7) at minimum inhibitory concentration (MIC) at 6.25 mu g/mL while rhamnolipid b showed MIC against insect cell line C6/36 at 50 mu g/mL. (c) 2006 Published by Elsevier Ltd.

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  • Anisaldehyde, a Melanogenesis Potentiator Reviewed

    *T. Nitoda, M. D. Fan, and I. Kubo

    Zeitschrift fur Naturforschung C   62c ( 1月2日 )   143 - 149   2007.2

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  • Chemical structures and biological activities of rhamnolipids produced by Pseudomonas aeruginosa B189 isolated from milk factory waste Reviewed

    Benjamas Thanomsub, Wanna Pumeechockchai, Anirut Limtrakul, Panarat Arunrattiyakorn, Wipawan Petchleelaha, Teruhiko Nitoda, Hiroshi Kanzaki

    BIORESOURCE TECHNOLOGY   97 ( 18 )   2457 - 2461   2006.12

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    The aim of this work was to study chemical structures and biological activities of rhamnolipids produced by Pseudomonas aeruginosa B189 isolated from milk factory waste. The culture produced two biosurfactants, a and b, which showed strong activity and were identified as L-rhamnopyranosyl-L-rhamnopyranosyl-beta-hydroxydecanoyl-beta-hydroxydecanoate or Rha-Rha C-10-C-10 and L-rhamnopyranosyl-L-rhamnopyranosyl-beta-hydroxydecanoyl-beta-hydroxydodecanoate or Rha-Rha C-10-C-12, respectively. Both compounds exhibited higher surfactant activities tested by the drop collapse test than several artificial surfactants such as SDS and Tween 80. Rhamnolipid a showed significant antiproliferative activity against human breast cancer cell line (MCF-7) at minimum inhibitory concentration (MIC) at 6.25 mu g/mL while rhamnolipid b showed MIC against insect cell line C6/36 at 50 mu g/mL. (c) 2005 Published by Elsevier Ltd.

    DOI: 10.1016/j.biortech.2005.10.029

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  • P-374 ISOLATION AND STRUCTURE ELUCIDATION OF A NOVEL ENZYME INHIBITOR SPECIFIC FOR BETA-N-ACETYLGLUCOSAMINIDASES OF INSECT & FUNGAL ORIGIN

    Usuki Hirokazu, Nitoda Teruhiko, Yamaji Nahoko, Iwashita Takashi, Komura Hajime, Kanzaki Hiroshi

    International Symposium on the Chemistry of Natural Products   2006   "P - 374"   2006.7

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    DOI: 10.24496/intnaturalprod.2006.0__P-374_

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  • P-373 ISOLATION OF CYCLIC DIPEPTIDES FROM MICROBIAL CULTURE GUIDED BY ENZYMATIC CONVERSION

    Arunrattiyakorn Panarat, Nitoda Teruhiko, Kanzaki Hiroshi

    International Symposium on the Chemistry of Natural Products   2006   "P - 373"   2006.7

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    DOI: 10.24496/intnaturalprod.2006.0__P-373_

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  • P-398 PRECURSOR-DIRECTED BIOSYNTHESIS & ENZYMATIC SYNTHESIS OF FLUORINATED ALBONOURSIN

    Kanzaki Hiroshi, Hirata Rie, Fukatani Yoshimi, Takeda Chikahiro, Ikeda Hajime, Nitoda Teruhiko

    International Symposium on the Chemistry of Natural Products   2006   "P - 398"   2006.7

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    DOI: 10.24496/intnaturalprod.2006.0__P-398_

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  • Enzymatic conversion-based method for screening cyclic dipeptide-producing microbes. Reviewed

    Arunrattiyakorn, P, Nitoda, T, Kanzaki, H

    Peptides   27 ( 4 )   633 - 639   2006.4

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  • Enzymatic conversion-based method for screening cyclic dipeptide-producing microbes Reviewed

    P Arunrattiyakorn, T Nitoda, H Kanzaki

    PEPTIDES   27 ( 4 )   633 - 639   2006.4

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    We developed a method for screening cyclic dipeptide-producing microbes by enzymatic conversion. In this method, cyclic dipeptides are detected by the combination of: (i) conversion of cyclic dipeptides to dehydro cyclic dipeptides by cyclo(Leu-Phe) oxidase and (ii) detection of the dehydro derivative by UV spectrophotometry using TLC or HPLC analysis based on the absorbance change caused by the conversion. Using this method, the actinomycete strain A8 was isolated as a cyclic dipeptide-producing strain. The cyclic dipeptides were purified from the microbial extract by enzymatic detection-guided fractionation, and their structures were determined to be CYCIO(L-Phe-L-Pro) and cycIO(L-Pro-L-Tyr) by spectroscopic methods. (c) 2005 Elsevier Inc. All rights reserved.

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  • Screening and partial characterization of inhibitors of insect β-N-acetylglucosaminidase Reviewed

    Usuki, Hirokazu; Nitoda, Teruhiko; Okuda, Toru; Kanzaki, Hiroshi.

    Journal of Pesticide Science   31 ( 1 )   41 - 46   2006

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  • Screening and partial characterization of inhibitors of insect .BETA.-N-acetylglucosaminidase Reviewed

    Hirokazu Usuki, Teruhiko Nitoda, Toru Okuda, Hiroshi Kanzaki

    Journal of Pesticide Science   31 ( 1 )   41 - 46   2006

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  • Bile acids are new products of a marine bacterium, Myroides sp strain SM1 Reviewed

    S Maneerat, T Nitoda, H Kanzaki, F Kawai

    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY   67 ( 5 )   679 - 683   2005.6

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    Strain SM1 was isolated as a biosurfactant-producing microorganism from seawater and presumptively identified as Myroides sp., based on morphology, biochemical characteristics and 16S rDNA sequence. The strain produced surface-active compounds in marine broth, which were purified, using emulsification activity for n-hexadecane as an indicator. The purified compounds were identified by thin-layer chromatography, H-1- and C-13-NMR spectra and fast atom bombardment mass spectrometry as cholic acid, deoxycholic acid and their glycine conjugates. Type strains of the genus Myroides, M. odoratus JCM7458 and M. odoramitimus JCM7460, also produced these compounds. Myroides sp. strain SM1 possessed a biosynthetic route to cholic acid from cholesterol. Thus, bile acids were found as new products of prokaryotic cells, genus Myroides.

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  • Bile acids are new products of a marine bacterium, Myroides sp. strain SM1 Reviewed

    Suppasil Maneerat, Teruhiko Nitoda, Hiroshi Kanzaki, Fusako Kawai

    Applied Microbiology and Biotechnology   67   679 - 683   2004.11

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  • Enzymatic synthesis of dehydro cyclo(His-Phe)s, analogs of the potent cell cycle inhibitor, dehydrophenylahistin, and their inhibitory activities toward cell division Reviewed

    Hiroshi Kanzaki, Satohiro Yanagisawa, Teruhiko Nitoda

    Bioscience, Biotechnology and Biochemistry   68 ( 11 )   2341 - 2345   2004.11

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    Cyclo(His-Phe) was effectively converted to its dehydro derivatives by the enzyme of Streptomyces albulus KO-23, an albonoursin-producing actinomycete. Two types of dehydro derivatives were isolated from the reaction mixture and identified as cyclo(ΔHis-ΔPhe) and cyclo(His-ΔPhe). This is the first report on cyclo(His-ΔPhe) and the enzymatic preparation of both compounds. Cyclo(ΔHis-ΔPhe), a tetradehydro cyclic dipeptide, exhibited a minimum inhibitory concentration of 0.78 μmol/ml inhibitory activity toward the first cleavage of sea urchin embryos, in contrast to cyclo(His-ΔPhe) that had no activity. The finding that the isoprenylated derivative of cyclo(ΔHis-ΔPhe), dehydrophyenylahistin, had 2,000 times higher activity than cyclo(ΔHis-APhe) indicates that an isoprenyl group attached to an imidazole ring of the compound was essential for the inhibitory activity.

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  • Monoacylglycerols: glycolipid biosurfactants produced by a thermotolerant yeast, Candida ishiwadae

    Thanomsub, B. Watcharachaipong, T. Chotelersak, K. Arunrattiyakorn, P. *Nitoda, T. Kanzaki, H.

    Journal of Applied Microbiology   2004.3

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  • Permeation and metabolism of a series of novel lipophilic ascorbic acid derivatives, 6-O-acyl-2-O-alpha-D-glucopyranosyl-L-ascorbic acids with a branched-acyl chain, in a human living skin equivalent model

    Tai, Akihiro Goto, Satomi Ishiguro, Yutaka Suzuki, Kazuko *Nitoda, Teruhiko Yamamoto, Itaru

    Bioorganic & medicinal chemistry letters   2004.3

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  • Permeation and metabolism of a series of novel lipophilic ascorbic acid derivatives, 6-O-acyl-2-O-alpha-D-glucopyranosyl-L-ascorbic acids with a branched-acyl chain, in a human living skin equivalent model Reviewed

    A Tai, S Goto, Y Ishiguro, K Suzuki, T Nitoda, Yamamoto, I

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   14 ( 3 )   623 - 627   2004.2

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    A series of novel lipophilic vitamin C derivatives, 6-O-acyl-2-O-alpha-D-glucopyranosyl-L-ascorbic acids possessing a branched-acyl chain of varying length from C-8 to C-16 (6-bAcyl-AA-2G), were evaluated as topical prodrugs of ascorbic acid (AA) with transdermal activity in a human living skin equivalent model. The permeability of 6-bAcyl-AA-2G was compared with those of the derivatives having a straight-acyl chain (6-sAcyl-AA-2G). Out of 10 derivatives of 6-sAcyl-AA-2G and 6-bAcyl-AA-2G, 6-sDode-AA-2G and 6-bDode-AA-2G exhibited most excellent permeability in this model. Measurement of the metabolites permeated from the skin model suggested that 6-bDode-AA-2G was mainly hydrolyzed via 6-O-acyl AA to AA by tissue enzymes, while 6-sDode-AA-2G was hydrolyzed via 2-O-alpha-D-glucopyranoSyl-L-ascorbic acid to AA. The former metabolic pathway seems to be advantageous for a readily available source of AA, because 6-O-acyl AA, as well as AA, is able to show vitamin C activity. (C) 2003 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.bmcl.2003.11.059

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  • A Potent Insect Chitinase Inhibitor of Fungal Origin Reviewed

    Teruhiko Nitoda, Hirokazu Usuki, Hiroshi Kanzaki

    Zeitschrift für Naturforschung C   58 ( 11-12 )   891 - 894   2003.12

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    <title>Abstract</title>
    A water-soluble polysaccharide was isolated from the culture filtrate of a fungal strain, Sphaeropsis sp. TNPT116-Cz, as a novel insect chitinase inhibitor. It was purified to chromatographic homogeneity by ethanol precipitation, anion-exchange and gel filtration chromatography. Its molecular weight was estimated to be 16 kDa by gel filtration HPLC. Monosaccharide analysis showed that it contained glucose, galactose, N-acetylglucosamine and a deoxysugar. This polysaccharide showed potent and specific inhibitory activity against Spodoptera litura chitinase with an IC50 value of 28 nᴍ.

    DOI: 10.1515/znc-2003-11-1226

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  • A potent insect chitinase inhibitor of fungal origin Reviewed

    *Nitoda, Teruhiko Usuki, Hirokazu Kanzaki, Hiroshi

    Zeitschrift fur Naturforschung. C, Journal of biosciences   58 ( 11-12 )   891 - 894   2003.11

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  • Tin-carbon cleavadge of organotin compounds by pyoverdine from Pseudomonas chlororaphis.

    Hiroyuki Inoue, Osamu Takimura, Ken Kawaguchi, *Teruhiko Nitoda, Hiroyuki Fuse, Katsuji Murakami, and Yukiho Yamaoka.

    Applied and Environmental Microbiology   2003.2

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  • (-)-Olivil and (+)-1-Acetoxypinoresinol from the Olive Tree (Olea europaea LINNE; Oleaceae) as Feeding Stimulants of the Olive Weevil (Dyscerus perforatus)(Organic Chemistry)

    KADOWAKI Emiko, YOSHIDA Yasuhiro, NITODA Teruhiko, BABA Naomichi, NAKAJiMA Shuhei

    Bioscience, biotechnology, and biochemistry   67 ( 2 )   415 - 419   2003.2

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    Guided by a feeding stimulant activity test on the olive weevil (Dyscerus perforatus), two compounds that showed potent feeding stimulant activity were isolated from the olive tree (Olea europaea). Based on their spectral data and a literature survey, they were identified as (-) -olivil (1) and (+) -1-acetoxypinoresinol (2). The activities of these minor lignans were significantly higher for the female than for the male weevil.

    DOI: 10.1271/bbb.67.415

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  • Effective production of potent cell cycle inhibitor dehydrophenylahistin by a combination of chemical racemization and Streptomyces enzyme-catalyzed conversion. Reviewed

    Kanzaki, H, Ikeda, B, Nitoda, T

    Actinomycetologica   17 ( 1 )   1 - 5   2003

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  • Macromolecular insect chitinase inhibitors produced by fungi: Screening and partial characterization Reviewed

    *T Nitoda, H Usuki, A Kurata, H Kanzaki

    JOURNAL OF PESTICIDE SCIENCE   28 ( 1 )   33 - 36   2003

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  • Effective Production of Potent Cell Cycle Inhibitor Dehydrophenylahistin by a Combination of Chemical Racemization and Streptomyces Enzyme-catalyzed Conversion. Reviewed

    Hiroshi Kanzaki, Banri Ikeda, Teruhiko Nitoda

    Actinomycetologica   17 ( 1 )   1 - 5   2003

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    DOI: 10.3209/saj.17_1

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  • Macromolecular Insect Chitinase Inhibitors Produced by Fungi: Screening and Partial Characterization Reviewed

    Teruhiko NITODA, Hirokazu USUKI, Atsushi KURATA, Hiroshi KANZAKI

    Journal of Pesticide Science   28 ( 1 )   33 - 36   2003

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    DOI: 10.1584/jpestics.28.33

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  • A novel potent cell cycle inhibitor dehydrophenylahistin. - Enzymatic synthesis and inhibitory activity toward sea urchin embryo Reviewed

    Hiroshi Kanzaki, Satohiro Yanagisawa, Kaneo Kanoh, Teruhiko Nitoda

    Journal of Antibiotics   55 ( 12 )   1042 - 1047   2002.12

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    A novel dehydrogenated cyclic dipeptide named as dehydrophenylahistin (APLH) was effectively prepared from a fungal metabolite (-)-phenylahistin by the enzymatic conversion catalyzed by the cell-free extract of Streptomyces albulus KO-23, an albonoursin-producing actinomycete. ΔPLH exhibited more than 1,000 times as high potent inhibitory activity toward the first cleavage of sea urchin embryos as (-)-phenylahisitn which has been reported to be a cell cycle inhibitor and more than 10,000 as high as albonoursin, indicating that ΔPLH is a promising leading compound for anticancer drugs.

    DOI: 10.7164/antibiotics.55.1042

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  • First synthesis of phosphatidylcholine and cholesteryl derivatives bearing an unsaturated aldehyde residue.

    Arnold N. Onyango, *Teruhiko Nitoda, Takao Kaneko, Mitsuyoshi Matsuo, Shuhei Nakajima, and Naomichi Baba.

    Journal of the Chemical Society, Perkin Transactions 1   2002.8

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  • Synthesis of a novel lysophosphatidylcholine

    Zhu, C., Morimoto, T., Nakajima, S., Nitoda, T.*, Baba, N.

    Journal of Natural Products   2001.1

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  • Biosynthetic Intermediates of the Tetradehydro Cyclic Dipeptide Albonoursin Produced by Streptomyces albulus KO-23

    KANZAKI Hiroshi, YANAGISAWA Satohiro, NITODA Teruhiko

    J. Antibiotics   53 ( 11 )   1257 - 1264   2000.11

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  • Structural Features of N-Glycans Linked to Royal Jelly Glycoproteins : Structures of high-mannose type, hybrid type, and biantennary type glycans

    KIMURA Yoshinobu, MIYAGI Chiyoko, KIMURA Mariko, NITODA Teruhiko, KAWAI Nobuyuki, SUGIMOTO Hiroyuki

    Bioscience, biotechnology, and biochemistry   64 ( 10 )   2109 - 2120   2000.10

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    The structures of N-glycans of total glycoproteins in royal jelly have been explored to clarify whether antigenic N-glycans occur in the famous health food. The structural feature of N-glycans linked to glycoproteins in royal jelly was first characterized by immunoblotting with an antiserum against plant complex type N-glycan and lectin-blotting with Con A and WGA. For the detail structural analysis of such N-glycans, the pyridylaminated (PA-) N-glycans were prepared from hydrazinolysates of total glycoproteins in royal jelly and each PA-sugar chain was purified by reverse-phase HPLC and size-fractionation HPLC. Each structure of the PA-sugar chains purified was identified by the combination of two-dimensional PA-sugar chain mapping, ESI-MS and MS/MS analyses, sequential exoglycosidase digestions, and 500 MHz ^1H-NMR spectrometry. The immunoblotting and lectinblotting analyses preliminarily suggested the absence of antigenic N-glycan bearing β1-2 xylosyl and/or α1-3 fucosyl residue (s) and occurrence of β1-4GlcNAc residue in the insect glycoproteins. The detailed structural analysis of N-glycans of total royal jelly glycoproteins revealed that the antigenic N-glycans do not occur but the typical high mannose-type structure (Man_<9-4>GlcNAc_2) occupies 71.6% of total N-glycan, biantennary-type structures (GlcNAc_2Man_3GlcNAc_2) 8.4%, and hybrid type structure (GlcNAc_1Man_4GlcNAc_2) 3.0%. Although the complete structures of the remaining 17% N-glycans ; C4,(HexNAc_3Hex_3HexNAc_2 : 3.0%), D2 (HexNAc_2Hex_5HexNAc_2 : 4.5%), and D3 (HexNAc_3Hex_4HexNAc_2 : 9.5%) are still obscure so far, ESI-MS analysis, exoglycosidase digestions by two kinds of β-N-acetylglucosaminidase, and WGA blotting suggested that these N-glycans might bear a β1-4 linkage N-acetylglucosaminyl residue.

    DOI: 10.1271/bbb.64.2109

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  • Two antinematodal phenolics from Knema hookeriana, a Sumatran rainforest plant

    ALEN Y.

    Z. Naturforsch.   55   300 - 303   2000.4

  • Antinematodal activity of some tropical rainforest plants against the pinewood nematode, Bursaphelenchus xylophilus

    Alen, Y., Nakajima, S., Nitoda, T*., Baba, N., Kanzaki, H., Kawazu, K.

    Zeitschrift Fur Naturforschung. Section C. Journal of Biosciences   2000.4

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  • Enzymatic conversion of cyclic dipeptides to dehydro derivatives that inhibit cell division Reviewed

    Kanzaki H, Imura D, Nitoda T, Kawazu K

    Journal of Bioscience and Bioengineering   90 ( 1 )   86 - 89   2000

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  • Effective production of dehydro cyclic dipeptide albonoursin exhibiting pronuclear fusion inhibitory activity II. Biosynthetic and bioconversion studies Reviewed

    Hiroshi Kanzaki, Daisuke Imura, Teruhiko Nitoda, Kazuyoshi Kawazu

    Journal of Antibiotics   53 ( 1 )   58 - 62   2000

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    Albornoursin production was greatly enhanced when cycle (r-Leu-L-Phe) (CFL), a tetrahydro derivative of albonoursin, was added to the 2-day culture of an albonoursin-producing actinomycete, Streptomyces albulus KO-23. The increase in albonoursin production paralleled the amount of CFL added. Furthermore, the resting cells of the strain catalyzed the bioconversion of CFL to albonoursin. The optimum pH and temperature for the conversion were found to be pH 10.0 and 50°C. The feeding experiments and the resting-cell reactions revealed that albonoursin is biosynthesized by dehydrogenation of CFL in the actinomycete. This is the first report for a dehydrogenation of amino acid residues at the α,β-positions in cyclic dipeptides.

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  • Novel diketopiperazine metabolism in a microorganism: Two-step hydrolysis of cyclo(Gly-Leu) to amino acids and preliminary characterization of cyclo(Gly-Leu) hydrolase and dipeptidase Reviewed

    Hiroshi Kanzaki, Naoki Mizuta, Teruhiko Nitoda, Kazuyoshi Kawazu

    Journal of Bioscience and Bioengineering   89 ( 6 )   602 - 605   2000

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    A bacterium, strain NM 5-3, isolated from soil exhibited the highest cyclo(Gly-Leu) (CGL)-hydrolyzing activity and was identified as Agrobacterium radiobacter. The reaction products from CGL were dipeptides (Leu-Gly and Gly-Leu) and amino acids (Leu and Gly). Inhibitors for the dipeptidase of this strain did not inhibit the hydrolysis of CGL to dipeptides, indicating that two distinct enzymes, CGLase and a dipeptidase, were involved in its hydrolysis. The activities of these two enzymes were separated by anion-exchange column chromatography. The results indicated that strain NM5-3 hydrolyzed CGL via the dipeptides to the corresponding amino acids. The CGLase fraction was found to catalyze the hydrolysis of cyclo(Gly-D-Leu), cyclo(Gly-Gly), cyclo(L-Ala-Gly), and cyclo(D-Ala-Gly). On the other hand, the dipeptidase fraction exhibited L-specific substrate specificity.

    DOI: 10.1016/S1389-1723(00)80064-X

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  • Enzymatic conversion of cyclic dipeptides to dehydro derivatives that inhibit cell division Reviewed

    Hiroshi Kanzaki, Daisuke Imura, Teruhiko Nitoda, Kazuyoshi Kawazu

    Journal of Bioscience and Bioengineering   90 ( 1 )   86 - 89   2000

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    The cell-free extract of an albonoursin-producing strain, Streptomyces albulus KO-23, was found to catalyze the conversion of several cyclic dipeptides having Phe and aliphatic side chain-containing amino acid residues to the corresponding dehydro derivatives. 3Z-Benzylidene-6S-methyl-2,5-piperazinedione, 3Z-benzylidene-2,5-piperazinedione, and 3Z, 6Z-dibenzylidene-2,5-piperazinedione were prepared by this conversion system. Among the dehydro cyclic dipeptides prepared, tetradehydro derivatives exhibited inhibitory activity toward the first cleavage of sea urchin embryo, while didehydro derivatives did not. We previously found that cyclo(Leu-Phe) and its didehydro derivatives did not show any inhibitory activity, in contrast to high activity in the case of albonoursin. Taken together, these findings indicate that dehydrogenation at the α, β-positions of both amino acid residues in this type of cyclic dipeptide is required for the inhibitory activity.

    DOI: 10.1016/S1389-1723(00)80039-0

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  • Improved bioassay method for Spodoptera litura chitinase inhibitors using a colloidal chitin powder with a uniform particle size as substrate Reviewed

    T Nitoda, H Kurumatani, H Kanzaki, K Kawazu

    PESTICIDE SCIENCE   55 ( 5 )   563 - 565   1999.5

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  • Improved bioassay method for Spodoptera litura chitinase inhibitors using a colloidal chitin powder with a uniform particle size as substrate Reviewed

    Nitoda, T, Nitoda, T) Kurumatani, H (Kurumatani, H) Kanzaki, H (Kanzaki, H) Kawazu, K, Kawazu

    Pesticide Science   55 ( 5 )   563 - 565   1999.5

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  • Novel cyclic dipeptide dehydrogenase and assay method for its activity

    Kanzaki, Hiroshi Akazawa, Kazumi Imura, Daisuke *Nitoda, Teruhiko

    Okayama Daigaku Nogakubu Gakujutsu Hokoku   1999.2

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  • Insect-neuroactive substances in two species of the genus Liquidamber

    Nakajima, S. Takeda, T. Nakahira, K. *Nitoda, T. Baba, N.

    Pesticide Science   1999.2

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  • Inhibition of Plant Transformation by Phytolaccoside B fromPhytolacca americanaCallus Reviewed

    Hiroshi KANZAKI, Toshihiko KAGEMORI, Yoko YAMACHIKA, Teruhiko NITODA, Kazuyoshi KAWAZU

    Bioscience, Biotechnology, and Biochemistry   63 ( 9 )   1657 - 1659   1999.1

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    The newly established GUS expression bioassay on the callus extracts of 22 species of plants revealed that the methanol extract of Phytolacca americana callus had the most potent inhibitory activity against agrobacterial plant transformation. A triterpene glycoside phytolaccoside B was isolated from the extract as a genuine plant transformation inhibitor having neither antiagrobacterial nor phytotoxic activity. This compound is promising for use as a biochemical probe for studies on the plant transformation mechanism.

    DOI: 10.1271/bbb.63.1657

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  • Inhibition of Plant Transformation by Phytolaccoside B from Phytolacca americana Callus. Reviewed

    Kanzaki, H, Kagemori, T, Yamachika, Y, Nitoda, T, Kawazu, K

    Bioscience, Biotechnology and Biochemistry   63 ( 9 )   1657 - 1659   1999

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  • Novel bioactive oxazolomycin isomers produced by Streptomyces albus JA3453 Reviewed

    H Kanzaki, K Wada, T Nitoda, K Kawazu

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   62 ( 3 )   438 - 442   1998.3

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    Two novel oxazolomycin isomers, oxazolomycins B (2) and C (3), were isolated from the fermentation broth of an oxazolomycin-producing strain, Streptomyces albus JA3453. Both compounds are geometrical isomers of oxazolomycin (1), the configurations of their triene moieties being (4'E, 6'E, 8'E) (2) and (4'Z, 6'E, 8'E) (3) while that of oxazolomycin fl) is (4'Z, 6'Z, 8'E), Compounds 2 and 3 exhibited potent inhibitory activity against crown gall formation with the same MIC (0.8 mu g/disk) as oxazolomycin. Compounds 2 and 3 showed no antibacterial activity against Agrobacterium tumefaciens, in contrast to oxazolomycin which has specific anti-A. tumefaciens activity.

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  • Synthesis of a novel sialic acid derivative (sialylphospholipid) as an antirotaviral agent Reviewed

    M Koketsu, T Nitoda, H Sugino, LR Juneja, M Kim, T Yamamoto, N Abe, T Kajimoto, CH Wong

    JOURNAL OF MEDICINAL CHEMISTRY   40 ( 21 )   3332 - 3335   1997.10

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    A novel sialylphospholipid (SPL) was synthesized from N-acetylneuraminic acid (NeuAc) and phosphatidylcholine (PC) by a chemical and enzymatic method and evaluated as an inhibitor of rotavirus. PC and 1,8-octanediol were conjugated by transesterification reaction of Streptomyces phospholipase D (PLD) under a water-chloroform biphasic system to afford phosphatidyloctanol, which was condensed with a protected 2-chloro-2-deoxyneuraminic acid derivative by using silver trifluoromethanesulfonate as an activator in chloroform and converted, after deprotection, to SPL. Rhesus monkey kidney cells (MA-104) were incubated with simian (SA-11 strain) and human (MO strain) rotaviruses in the presence of SPL, and the cells infected were detected indirectly with anti-rotavirus antibody. SPL showed dose dependent inhibition against both virus strains. The concentrations required for 50% inhibition (IC50) against SA-11 and MO were 4.35 and 16.1 mu M, respectively, corresponding to 10(3)- and 10(4)-fold increases in inhibition as compared to monomeric NeuAc.

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  • Antioxidative activity of egg yolk phospholipids Reviewed

    H Sugino, M Ishikawa, T Nitoda, M Koketsu, LR Juneja, M Kim, T Yamamoto

    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY   45 ( 3 )   551 - 554   1997.3

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  • Antioxidative Activity of Egg Yolk Phospholipids Reviewed

    Hidetoshi Sugino, Makoto Ishikawa, Teruhiko Nitoda, Mamoru Koketsu, Lekh Raj Juneja, Mujo Kim, Takehiko Yamamoto

    Journal of Agricultural and Food Chemistry   45 ( 3 )   551 - 554   1997.3

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  • Sialyloligosaccharides from Egg Yolk as an Inhibitor of Rotaviral Infection Reviewed

    Mamoru Koketsu, Teruhiko Nitoda, Lekh Raj Juneja, Mujo Kim, Naoki Kashimura, and Takehiko Yamamoto

    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY   43 ( 4 )   858 - 861   1995.4

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  • Sialyloligosaccharides from Egg Yolk as an Inhibitor of Rotaviral Infection Reviewed

    Mamoru Koketsu, Teruhiko Nitoda, Lekh Raj Juneja, Mujo Kim, Naoki Kashimura, Takehiko Yamamoto

    Journal of Agricultural and Food Chemistry   43 ( 4 )   858 - 861   1995.4

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Books

  • Isolation, Identification and Characterization of Allelochemicals/ Natural Products

    Teruhiko Nitoda, Hiroshi Kanzaki( Role: Joint author ,  Bioassays: Inhibitors of Insect Chitin-degrading Enzymes (pp.499-512))

    CRC Press  2009.1  ( ISBN:9781578085774

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MISC

  • Cyclo(Leu-Phe) oxidase が触媒する環状ジペプチド脱水素反応の反応初期における人工電子受容体添加の影響の定量的評価

    ○猪口慧悟, 坂口幸士朗, 仁戸田照彦, 神崎 浩

    学会創立100 周年記念 日本農芸化学会2023年度中四国・西日本支部合同大会 講演要旨集   2023.9

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  • Pochonia suchlasporia が生産するasteltoxin 類のMS/MS 分析を用いた探索

    ○加藤陽輝, 神崎 浩, 仁戸田照彦

    学会創立100 周年記念 日本農芸化学会2023年度中四国・西日本支部合同大会 講演要旨集   2023.9

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  • Inhibitory sensitivity of β-N-acetylglucosaminidase from Enterococcus sp. MK26 to N,N,N-trimethyl-β-D-glucosaminium-containing compounds

    〇K. Morioka, H. Ono, M. Koide, S. Suganuma, T. Nitoda, H. Kanzaki

    2023.9

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  • Search for chitinolytic enzyme inhibitors produced by microbobes Invited

    Hirokazu Usuki, Miho Toyo-oka, Hiroshi Kanzaki, ○Teruhiko Nitoda*

    2023.9

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  • Microbial Conversion of C-Glycoside Mangiferin into its Aglycone Norathyriol by Mammalian Intestinal Bacteria

    2023.9

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  • Distribution of mammalian gut microbiota capable of converting C-glycoside mangiferin into its aglycone norathyriol

    〇Y. Uga, U. Hasanah, H. Kayaki, H. Kawakami, Y. Nishitani, H. Kuwahara, T. Nitoda, H. Kanzaki

    2023.9

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  • Koji mold solid cultivation-mediated high functionalization of plant resources

    Agricultural Biotechnology   7 ( 8 )   744 - 748   2023.8

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  • 麹菌固体培養による杜仲葉二次代謝産物の微生物変換 (第2 報)

    ○村上 響, 奥川日菜乃, 山下秀行, 三木翔平, 仁戸田照彦, 神崎 浩

    支部創立20 周年記念 日本農芸化学会中四国支部第64 回講演会 講演要旨集   2023.1

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  • 糸状菌Pochonia suchlasporia TAMA87 株の固体培養による生薬センザンリュウ二次 代謝産物の微生物変換

    ○竹本実加, 神崎 浩, 仁戸田照彦

    支部創立20 周年記念 日本農芸化学会中四国支部第64 回講演会 講演要旨集   2023.1

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  • Bioconversion of olive leaf constituents by Aspergillus solid state fermentation using an air flow type rotary solid state fermenter for laboratory use

    辰巳七海, 橋本敦子, 奥川日菜乃, 三宅剛史, 伊藤一成, 谷野有佳, 竹内赴登, 山下秀行, 内田真美, 三木翔平, 吉田靖弘, 徐恵美, 菊地敬一, 深野夏暉, 仁戸田照彦, 仁戸田照彦, 神崎浩, 神崎浩

    日本農芸化学会大会講演要旨集(Web)   2023   2023

  • Creation of highly functionalized Japanese wine pomace koji using koji mold solid culture technology

    神崎浩, 仁戸田照彦, 伊藤一成, 谷野有佳, 竹内赴登

    Annual Report of the Okayama Foundation for Science and Technology   ( 32 )   2023

  • Bioconversion of skin and seed constituents by Aspergillus solid state fermentation of wine pomace

    藤田彩楓, 奥川日菜乃, 橋本敦子, 三宅剛史, 伊藤一成, 谷野有佳, 山下秀行, 中川拓郎, 平野幸司, 仁戸田照彦, 仁戸田照彦, 神崎浩, 神崎浩

    日本農芸化学会大会講演要旨集(Web)   2023   2023

  • Analysis of MS/MS fragmentation patterns for search of new asteltoxin analogs with a unique α-pyrone moiety

    三谷尚大, 神崎浩, 仁戸田照彦

    日本農薬学会大会講演要旨集   47th (CD-ROM)   2022

  • バイオサーファクタント・サーファクチンの自己集合特性への対カチオン種の違いによる影響

    柳澤恵広, 柳澤恵広, 平敏彰, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集(Web)   62nd   2022

  • Effect of steaming on Aspergillus solid state fermentation of olive leaves

    橋本敦子, 奥川日菜乃, 三宅剛史, 伊藤一成, 谷野有佳, 山下秀行, 内田真美, 三木翔平, 吉田靖弘, 徐恵美, 菊地敬一, 仁戸田照彦, 神崎浩

    日本農芸化学会大会講演要旨集(Web)   2022   2022

  • Effect of hot water pretreatment on Aspergillus solid state fermentation of wine pomace

    奥川日菜乃, 橋本敦子, 三宅剛史, 伊藤一成, 谷野有佳, 山下秀行, 中川拓郎, 平野幸司, 仁戸田照彦, 神崎浩

    日本農芸化学会大会講演要旨集(Web)   2022   2022

  • Cyclo(Leu-Phe)oxidaseの幅広い基質特異性の定量的評価-天然の電子受容体を用いた活性測定と人工の電子受容体を用いた活性測定の比較-

    坂口幸士朗, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集(Web)   61st   2022

  • High functionalization of Japanese wine pomace constituents by Aspergillus solid-state fermentation

    奥川日菜乃, 橋本敦子, 三宅剛史, 伊藤一成, 谷野有佳, 山下秀行, 中川拓郎, 平野幸司, 仁戸田照彦, 神崎浩

    日本農芸化学会大会講演要旨集(Web)   2021   2021

  • High functionalization of olive leaf constituents by Aspergillus solid state fermentation

    橋本敦子, 奥川日菜乃, 三宅剛史, 伊藤一成, 谷野有佳, 山下秀行, 内田真美, 三木翔平, 吉田靖弘, 徐恵美, 菊地敬一, 仁戸田照彦, 神崎浩

    日本農芸化学会大会講演要旨集(Web)   2021   2021

  • 麹菌固体培養による日本ワインパミス成分の高機能化(第2報)

    奥川日菜乃, 橋本敦子, 三宅剛史, 伊藤一成, 谷野有佳, 山下秀行, 中川拓郎, 平野幸司, 仁戸田照彦, 神崎浩

    日本農芸化学会西日本支部大会およびシンポジウム講演要旨集   2021 (CD-ROM)   2021

  • 麹菌固体培養による杜仲葉二次代謝産物の微生物変換

    村上響, 奥川日菜乃, 山下秀行, 三木翔平, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集(Web)   59th   2021

  • Microbial conversion of constituents of Eucommia ulmoides leaves into useful compounds

    仁戸田照彦, 神崎浩

    日本杜仲研究会定期大会講演要旨集   15th   2021

  • Adipogenesis Suppression by Enokitake Mushroom Bed Extract and its Application to Pet Animal Supplements

    神崎浩, 仁戸田照彦, 畑生俊光

    Bio Industry   38 ( 2 )   2021

  • Penicillium aurantiogriseumが触媒するAspergillus ustus代謝物の新規フロイソキノリンアルカロイドへの変換反応

    山田光代, 齊藤太樹, 小川凌太, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集(Web)   58th   2021

  • Synthesis of pNP-TMG via electrochemical glycosylation

    桑名春希, 矢野君晟, 野上敏材, 仁戸田照彦, 神崎浩

    日本化学会春季年会講演予稿集(CD-ROM)   100th   2020

  • Quantitative evaluation of the substrate specificity of cyclo(Leu-Phe)oxidase toward various cyclodipeptides

    坂口幸士朗, 小西健太, 仁戸田照彦, 神崎浩

    生体触媒化学シンポジウム講演要旨集   22nd (CD-ROM)   2020

  • Investigation of the sensitivity of β-N-acetylglucosaminidase from p-nitrophenyl N-acetyl-β-D-glucosaminide assimilating bacteria to N,N,N-trimethylglucosaminium containing compounds

    小出麻奈, 菅沼笙子, 仁戸田照彦, 神崎浩

    日本農芸化学会大会講演要旨集(Web)   2020   2020

  • A novel furo-isoqunoline alkaloid formed from Aspergillus ustus metabolites by Penicillium aurantiogriseum catalyst

    山田光代, 齊藤太樹, 小川凌太, 仁戸田照彦, 神崎浩

    日本農芸化学会大会講演要旨集(Web)   2020   2020

  • Pochonia suchlasporiaの固体培養により生産される糸状菌胞子発芽阻害物質(第2報)

    片岡智範, 神崎浩, 仁戸田照彦

    日本農芸化学会中四国支部講演会講演要旨集(Web)   56th   2020

  • エノキタケを栽培した針葉樹菌床の水抽出物が示す脂肪蓄積抑制効果

    畑本梨衣, 永谷直哉, 仁戸田照彦, 畑生俊光, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集(Web)   56th   2020

  • Aspergillus ustusとPenicillium aurantiogriseumの組み合わせ培養により生産される新規フロイソキノリンアルカロイド

    山田光代, 齊藤太樹, 小川凌太, 仁戸田照彦, 神崎浩

    生体触媒化学シンポジウム講演要旨集   21st   2019

  • Aspergillus ustusとPenicillium aurantiogriseumの組み合わせ培養により生産される新規フロイソキノリンアルカロイドの絶対立体配置の決定

    山田光代, 齊藤太樹, 小川凌太, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集(Web)   54th   2019

  • Pochonia suchlasporiaの固体培養により生産される糸状菌胞子発芽阻害物質

    片岡智範, 神崎浩, 仁戸田照彦

    日本農芸化学会大会講演要旨集(Web)   2019   2019

  • マウス腸内細菌叢によるC-配糖体mangiferinからそのアグリコンnorathyriolへの変換

    三木香澄, 川上秀昭, 西谷洋輔, 桑原浩誠, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集(Web)   53rd   2019

  • 過酸化水素定量を利用したCyclo(Leu-Phe)oxidaseの活性測定法の確立と基質特異性検討

    小西健太, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集(Web)   53rd   2019

  • オリーブ葉二次代謝産物3,4-dihydroxyphenylethanol-elenolic acidの還元を触媒するSaccharomyces cerevisiae由来酵素の探索と同定

    松川加奈, 巻尾沙織, 仁戸田照彦, 守屋央郎, 神崎浩

    生体触媒化学シンポジウム講演要旨集   20th   2018

  • Penicillium multicolorが生産する3種のp-nitrophenyl β-D-glucopyranosideの分解酵素の基質特異性に関する比較研究

    小出麻奈, 菅沼笙子, 仁戸田照彦, 神崎浩

    生体触媒化学シンポジウム講演要旨集   20th   2018

  • Saccharomyces cerevisiae由来alcohol dehydrogenase6は3,4-dihydroxyphenylethanol-elenolic acidの還元を触媒する

    松川加奈, 巻尾沙織, 仁戸田照彦, 守屋央郎, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集(Web)   52nd   2018

  • Penicillium multicolorが生産する3種のp-nitrophenyl β-D-glucopyranoside分解酵素が触媒するL-アスコルビン酸への糖転移反応における基質特異性の比較研究

    小出麻奈, 菅沼笙子, 仁戸田照彦, 神崎浩

    日本農芸化学会大会講演要旨集(Web)   2018   2018

  • β-N-Acetylglucosaminidase阻害物質TMG-chitotriomycin類縁体のLC-MSによる安定性および構造の検討

    田淵勇, 淺尾昂平, 水田雄大, 神崎浩, 仁戸田照彦

    日本農芸化学会中四国支部講演会講演要旨集(Web)   50th   2018

  • Aspergillus ustusとPenicillium aurantiogriseumの組み合わせ培養により生産される新規イソキノリンアルカロイドの生成経路

    小川凌太, 齊藤太樹, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集(Web)   49th   2017

  • Cyclo(Leu-Phe)酸化酵素が有する広い基質特異性を利用したMet含有環状ジペプチドの変換反応

    小西健太, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集(Web)   49th   2017

  • 糖供与体選択性の異なるβ-グルコシダーゼが触媒するL-アスコルビン酸への糖転移反応の速度論的研究

    菅沼笙子, 寺坂美紀, 仁戸田照彦, 神崎浩

    日本農芸化学会大会講演要旨集(Web)   2017   2017

  • β-N-Acetylglucosaminidase阻害物質pochonicineのアセチル化によるNOE相関への影響

    江本啓輔, 奥田徹, 神崎浩, 仁戸田照彦

    日本農芸化学会中四国支部講演会講演要旨集(Web)   44th   2016

  • β-N-Acetylglucosaminidase阻害物質pochonicineおよびその類縁体の構造活性相関:6位と7位の水酸基の寄与

    虫明優一, 土田彩, 奥田徹, 神崎浩, 仁戸田照彦

    日本農芸化学会中四国支部講演会講演要旨集(Web)   46th   2016

  • オリーブ葉二次代謝産物oleuropein aglycon及びその微生物変換により生成するreduced oleuropein aglyconの詳細構造解析

    古賀まり子, 栗原小蒔, 徐恵美, 菊地敬一, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集(Web)   46th   2016

  • オリーブ葉二次代謝産物oleuropein aglyconをreduced oleuropein aglyconへと変換するSaccharomyces cerevisiae由来酵素の探索

    巻尾沙織, 森吉弘, 仁戸田照彦, 守屋央朗, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集(Web)   46th   2016

  • L-アスコルビン酸への糖転移反応における基質特異性および位置特異性の異なるβ-グルコシダーゼの速度論的研究

    菅沼笙子, 寺坂美紀, 仁戸田照彦, 神崎浩

    日本農芸化学会大会講演要旨集(Web)   2016   2016

  • Aspergillus ustusとPenicillium aurantiogriseumの組み合わせ培養により生産される新規イソキノリンアルカロイド

    小川凌太, 齊藤太樹, 仁戸田照彦, 神崎浩

    日本農芸化学会大会講演要旨集(Web)   2016   2016

  • Cyclo(Leu-Phe)oxidaseを用いた酵素変換法により見出されるMucor petrinsularisの生産する環状ジペプチド

    徳島將光, 高橋佳子, 福田優, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集(Web)   44th   2016

  • 放線菌由来cyclo(Leu-Phe)oxidaseの脱水素反応における電子伝達に関する検討

    間野なお美, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集(Web)   44th   2016

  • 糸状菌が生産するβ-N-Acetylglucosaminidase阻害剤pochonicineの6,7-ジデオキシ類縁体

    虫明優一, 土田彩, 奥田徹, 神崎浩, 仁戸田照彦

    日本農芸化学会中四国支部講演会講演要旨集(Web)   43rd   2015

  • Penicillium multicolorが生産する2種類のβ-グルコシダーゼの基質特異性に関する研究

    菅沼笙子, 寺坂美紀, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集(Web)   43rd   2015

  • オリーブ葉二次代謝産物oleuropein aglyconを効率的に還元する微生物の探索

    巻尾沙織, 乗松毅, 徐恵美, 菊池敬一, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集(Web)   43rd   2015

  • オリーブ葉二次代謝産物oleuropein aglyconからreduced oleuropein aglyconへの反応を触媒するSaccharomyces cerevisiae由来酵素の同定

    森吉弘, 仁戸田照彦, 守屋央郎, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集(Web)   41st   2015

  • ヒト腸内細菌を用いたC-配糖体mangiferinからアグリコンnorathyriolへの効率的変換反応

    角南里美, 桑原浩誠, 奥田洋, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集(Web)   41st   2015

  • Aspergillus ustus由来新規イソキノリンアルカロイド

    齊藤太樹, 仁戸田照彦, 神崎浩

    日本農芸化学会大会講演要旨集(Web)   2015   2015

  • β-N-acetylglucosaminidase阻害物質TMG-chitotriomycinの新規類縁体の単離,構造解析

    淺尾昂平, 神崎浩, 仁戸田照彦

    日本農芸化学会大会講演要旨集(Web)   2015   2015

  • 糸状菌が生産する新規グリコシダーゼ阻害剤に関する研究

    仁戸田 照彦

    平成25年度 公益財団ウエスコ学術振興財団 事業報告書 研究成果報告書集   7 - 11   2014.3

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  • 起源の異なるβ-グルコシダーゼの加水分解活性と糖転移活性の比較研究

    寺坂美紀, 早川有美, 仁戸田照彦, 神崎浩

    日本農芸化学会大会講演要旨集(Web)   2014   2014

  • Aspergillus nigerの固体培養によるオリーブ葉二次代謝産物の微生物変換

    三宅聡子, 仁戸田照彦, 神崎浩

    日本農芸化学会大会講演要旨集(Web)   2014   2014

  • β-N-Acetylglucosaminidase阻害物質生産糸状菌が生産する昆虫成長制御物質

    高辻笑理, 奥田徹, 神崎浩, 仁戸田照彦

    日本農芸化学会中四国支部講演会講演要旨集   40th   2014

  • 農薬・医薬のリード化合物として有望な微生物由来新規グリコシダーゼ阻害剤の培養生産方法の検討

    財団法人両備?園記念財団 生物学に関する試験研究論叢   28   68 - 76   2013.9

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  • 起源の異なるβ-グルコシダーゼの加水分解活性と糖転移活性の比較研究

    寺坂美紀, 早川有美, 仁戸田照彦, 神崎浩

    生体触媒化学シンポジウム講演要旨集   17th   2013

  • β-N-Acetylglucosaminidase阻害物質TMG-chitotriomycinの関連化合物の探索

    淺尾昂平, 神崎浩, 仁戸田照彦

    日本農芸化学会中四国支部講演会講演要旨集   36th   2013

  • 放線菌由来cyclo(Leu-Phe)oxidaseの凝集性と可溶化の試み

    相澤ゆかり, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集   35th   2013

  • 2種類の微生物の組み合わせ培養による微生物変換

    齋藤太樹, 小坂亜弓, 仁戸田照彦, 神崎浩

    生体触媒化学シンポジウム講演要旨集   17th   2013

  • β-N-Acetylglucosaminidase阻害物質TMG-chitotriomycinの関連化合物のLC-MSによる探索

    淺尾昂平, 長谷井拓真, 神崎浩, 仁戸田照彦

    生体触媒化学シンポジウム講演要旨集   17th   2013

  • Aspergillus ustusとAspergillus repensとの組み合わせ培養で観察されるAspergillus repensの生育阻害

    高岡晶美, 仁戸田照彦, 神崎浩

    日本農芸化学会関西支部講演会講演要旨集   481st   2013

  • コロイダルキチンによる放射菌由来キチン分解酵素阻害物質の培養生産性への影響

    長谷井拓真, 淺尾昂平, 神崎浩, 仁戸田照彦

    日本農芸化学会関西支部講演会講演要旨集   481st   2013

  • Aspergillus ustusとPenicillium aurantiogriseumとの組み合わせ培養による単独培養で検出されない化合物の生産

    齊藤太樹, 小坂亜弓, 仁戸田照彦, 神崎浩

    日本農芸化学会関西支部講演会講演要旨集   481st   2013

  • 糸状菌Paecilomyces sp.F30株が生産するβ-N-acetylglucosaminidase阻害物質

    戎義子, 土田彩, 奥田徹, 神崎浩, 仁戸田照彦

    日本農芸化学会中四国支部講演会講演要旨集   35th   2013

  • ヒノキ木紛の生分解性向上のための白色腐朽菌処理

    小島豪, 時本景亮, 西野直樹, 仁戸田照彦, 神崎浩

    日本農芸化学会大会講演要旨集(Web)   2013   2013

  • C321 Inhibitory selectivity of β-N-acetylglucosaminidase inhibitor TMG-chitotriomycin

    Shiota Hiroto, Usuki Hirokazu, Kanzaki Hiroshi, Nitoda Teruhiko

    ( 37 )   158 - 158   2012.3

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  • 糸状菌Paecilomyces sp.F30株の生産するβ-N-Acetylglucosaminidase阻害剤

    戎義子, 奥田徹, 神崎浩, 仁戸田照彦

    生体触媒化学シンポジウム講演要旨集   16th   2012

  • β-N-Acetylglucosaminidase阻害物質TMG-chitotriomycinの阻害選択性に関する詳細検討

    塩田博人, 臼木博一, 臼木博一, 神崎浩, 仁戸田照彦

    日本農薬学会大会講演要旨集   37th   2012

  • アスコルビン酸の位置特異的な配糖化を触媒するAspergillus niger由来β-グルコシダーゼを用いたアスコルビン酸6βグルコシドの合成

    寺坂美紀, 早川有美, 仁戸田照彦, 神崎浩

    生体触媒化学シンポジウム講演要旨集   16th   2012

  • 発酵食品微生物由来環状ジペプチド類と関連化合物の抗酸化活性評価

    高津綾香, 福田優, CHAO Man, 仁戸田照彦, 神崎浩

    日本農芸化学会大会講演要旨集(Web)   2012   2012

  • アスコルビン酸の位置特異的な配糖化を触媒するAspergillus niger由来β-グルコシダーゼを用いたアスコルビン酸6βグルコシドの合成

    寺坂美紀, 早川有美, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集   33rd   2012

  • Cyclo(Leu-Phe)oxidase変換反応を受ける糸状菌由来二次代謝産物の検出

    高橋佳子, 福田優, 仁戸田照彦, 神崎浩

    日本農芸化学会大会講演要旨集(Web)   2012   2012

  • β-N-Acetylglucosaminidase阻害剤pochonicineのGC-MS分析及び新規類縁体の確認

    土田彩, 安井あゆみ, 奥田徹, 神崎浩, 仁戸田照彦

    日本農芸化学会中四国支部講演会講演要旨集   33rd   2012

  • ヒノキ木粉の生分解性を向上させる白色腐朽菌の探索

    小島豪, 光永均, 時本景亮, 西野直樹, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集   34th   2012

  • A203 Search for the analogs of β-N-acetylglucosaminidase inhibitor pochonicine produced by a fungal strain and improvement of their culture productivity

    Nitoda Teruhiko, Yamada Asami, Toyo-oka Miho, Usuki Hirokazu, Okuda Toru, Kanzaki Hiroshi

    ( 36 )   47 - 47   2011.2

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  • β-N-Acetylglucosaminidase阻害物質pochonicineとその類縁体の培養生産

    山田あさ美, 豊岡実穂, 臼木博一, 臼木博一, 奥田徹, 神崎浩, 仁戸田照彦

    日本農芸化学会中四国支部講演会講演要旨集   29th   2011

  • β-N-Acetylglucosaminidase阻害物質TMG-chitotriomycinの阻害特性

    塩田博人, 行本千恵, 臼木博一, 臼木博一, 神崎浩, 仁戸田照彦

    日本農芸化学会大会講演要旨集   2011   2011

  • 膜面液体培養による生理活性環状ジペプチド類の生産

    今宮亮, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集   29th   2011

  • 発酵食品微生物が生産する抗酸化活性環状ジペプチドの酵素変換手法を用いる検出

    神崎浩, 高津綾香, 福田優, CHAO Man, 仁戸田照彦

    日本放線菌学会大会講演要旨集   26th   2011

  • 放線菌Streptomyces anulatusにより生産されるβ-N-acetylglucosaminidase阻害剤の阻害選択性

    塩田博人, 臼木博一, 臼木博一, 神崎浩, 仁戸田照彦

    日本放線菌学会大会講演要旨集   26th   2011

  • 精製CFL oxidaseの凝集性確認と可溶化の試み

    相澤ゆかり, 仁戸田照彦, 神崎浩

    生体触媒化学シンポジウム講演要旨集   15th (Web)   2011

  • β-N-Acetylglucosaminidase阻害物質TMG-chitotriomycinの阻害選択性

    塩田博人, 臼木博一, 臼木博一, 神崎浩, 仁戸田照彦

    日本農芸化学会西日本支部大会およびシンポジウム講演要旨集   2011   2011

  • Conversion of secondary metabolites from olive leaves by Baker&apos;s yeasts and the antioxidative activity of the product

    Erika Akihisa, Yoshihiro Harada, Kumi Kobayashi, Akiko Hirano, Teruhiko Nitoda, Hiroshi Kanzaki

    JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC   62 ( 1 )   123 - 123   2010.1

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  • 乳酸菌が生産する環状ジペプチド類の酵素法による検出

    張曼, ARUNRATTIYAKORN Panarat, 烏力吉徳力根, 宮本拓, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集   26th   2010

  • β-N-アセチルグルコサミニダーゼ阻害物質生産菌Streptomyces anulatusにより生産されるキチナーゼ阻害物質の予備的性状解析

    塩田博人, 市川美里, 神崎浩, 仁戸田照彦

    日本農芸化学会中四国支部講演会講演要旨集   27th   2010

  • アスコルビン酸の6位水酸基を特異的にβ-グルコシル化するAspergillus niger由来酵素(第2報)-糖転移活性の詳細検討-

    早川有美, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部講演会講演要旨集   28th   2010

  • アスコルビン酸への糖転移反応を触媒しアスコルビン酸6βグルコシドを生成するAspergillus niger由来酵素(第2報)

    早川有美, 仁戸田照彦, 神崎浩

    生体触媒化学シンポジウム講演要旨集   14th   2010

  • β-N-アセチルグルコサミニダーゼ阻害物質生産菌Streptomyces anulatusによるキチナーゼ阻害物質の生産

    塩田博人, 市川美里, 臼木博一, 神崎浩, 仁戸田照彦

    生体触媒化学シンポジウム講演要旨集   14th   2010

  • Chemical structures and biological activities of rhamnolipids produced by Pseudomonas aeruginosa B189 isolated from milk factory waste (Retraction of vol 98, pg 1149, 2007)

    Benjamas Thanomsub, Wanna Pumeechockchai, Anirut Limtrakul, Panarat Arunrattiyakorn, Wipawan Petchleelaha, Teruhiko Nitoda, Hiroshi Kanzaki

    BIORESOURCE TECHNOLOGY   100 ( 23 )   6141 - 6141   2009.12

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  • 生物種の由来が異なる酵素を見分ける阻害剤 新規な構造と活性をもつ放線菌由来β-N-アセチルグルコサミニダーゼ阻害剤

    仁戸田 照彦, 臼木 博一, 神崎 浩

    化学と生物   47 ( 3 )   158 - 160   2009

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    DOI: 10.1271/kagakutoseibutsu.47.158

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  • β-N-アセチルグルコサミニダーゼ阻害剤MT-1の合成

    佐藤瑞穂, 豊岡実穂, 臼木博一, 仁戸田照彦, 神崎浩, 中島修平, 馬場直道, 泉実

    日本農芸化学会大会講演要旨集   2009   2009

  • Bioassays: inhibitors of insect chitin-degrading enzymes

    Teruhiko Nitoda, Hiroshi Kanzaki

    Isolation, Identification and Characterization of Allelochemicals/Natural Products   499 - 412   2009

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  • アスコルビン酸への糖転移反応を触媒しアスコルビン酸6βグルコシドを生成するAspergillus niger由来酵素

    早川有美, 水津佳子, 仁戸田照彦, 神崎浩

    生体触媒化学シンポジウム講演要旨集   13th   2009

  • アスコルビン酸の6位水酸基を特異的にβ-グルコシル化するAspergillus niger由来酵素

    早川有美, 水津佳子, 仁戸田照彦, 神崎浩

    日本農芸化学会関西支部講演会講演要旨集   2009   2009

  • Streptomyces albulus KO23株由来組換えcyclo(Leu-Phe)oxidaseの精製と諸性質

    今村六美, 畑中唯史, 臼木博一, 仁戸田照彦, 神崎浩

    生体触媒化学シンポジウム講演要旨集   13th   2009

  • Development of natural cosmetic materials-microbial conversion of olive antioxidative constituents

    Fragrance journal   36 ( 2 )   63 - 66   2008

  • Purification and characterization of cyclo (Leu-Phe) oxidase of Streptomyces albulus expressed in Escherichia coli

    Machiko Nagao, Rie Hirata, Teruhiko Nitoda, Hiroshi Kanzaki

    JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC   48 ( 3-4 )   108 - 108   2007.9

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  • A novel β-N-acetylglucosaminidase inhibitor of fungal origin

    NITODA Teruhiko, TOYOOKA Miho, USUKI Hirokazu, OKUDA Toru, KANZAKI Hiroshi

    32   123 - 123   2007.3

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  • 糸状菌由来の新規β-N-acetylglucosaminidase阻害剤

    仁戸田照彦, 豊岡実穂, 臼木博一, 奥田徹, 神崎浩

    日本農薬学会大会講演要旨集   32nd   2007

  • 微生物変換によるオリーブ二次代謝産物の高機能化

    神崎浩, 原田嘉広, 小林久美, 仁戸田照彦

    日本農芸化学会中四国支部講演会講演要旨集   18th (Web)   2007

  • Further proof for wide substrate specificity of cyclo(Leu-Phe) oxidase from an actinomycete: Enzymatic conversion of cyclic dipeptides containing non-aromatic amino acids - Abstracts

    Rie Hirata, Teruhiko Nitoda, Hiroshi Kanzaki

    JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC   42 ( 3-4 )   127 - 128   2006.11

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  • Microorganisms with homocysteine thiolactone hydrolase: Screening and stereospecificity - Abstracts

    Shozo Honda, Teruhiko Nitoda, Hiroshi Kanzaki

    JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC   42 ( 3-4 )   126 - 127   2006.11

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  • Inhibitory specificity of a novel β-N-acetylglucosaminidase inhibitor HU-1

    USUKI Hirokazu, NITODA Teruhiko, KANZAKI Hiroshi

    31   81 - 81   2006.3

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  • Structure elucidation of a novel β-N-acetylglucosaminidase inhibitor HU-1

    USUKI Hirokazu, NITODA Teruhiko, YAMAJI Nahoko, IWASHITA Takashi, KOMURA Hajime, KANZAKI Hiroshi

    31   82 - 82   2006.3

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  • 細胞分裂阻害物質phenylahistin生産糸状菌Aspergillus ustus由来のcyclo(Leu-Phe)酸化酵素により変換される新規二次代謝産物

    神崎浩, 杉原孝治, 平田里枝, 仁戸田照彦

    日本農芸化学会中四国支部講演会講演要旨集   14th (Web)   2006

  • 2D15-5 Synthesis of novel fluoro analogs of albonoursin by precursor-directed biosynthesis

    KANZAKI Hiroshi, TAKEDA Chikahiro, FUKATANI Yoshimi, NITODA Teruhiko

    17   135 - 135   2005

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  • 糸状菌TNPT116-Cz株が生産する昆虫キチナーゼ阻害多糖FPS-1の阻害特性(第2報)

    2004年度 日本農芸化学会中四国支部大会(口頭発表)   2004

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  • 昆虫のβ-N-acetylglucosaminidaseに特異的な阻害剤の探索(第2報)

    2004年度 日本農芸化学会中四国支部大会(口頭発表)   2004

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  • 昆虫のβ-N-acetylglucosaminidaseに特異的な阻害剤の探索

    2004年度日本農芸化学会大会(口頭発表)   2004

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  • 糸状菌TNPT116-Cz株が生産する昆虫キチナーゼ阻害物質FPS-1の阻害特異性

    2004年度日本農芸化学会大会(口頭発表)   2004

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  • 2J13-4 Thionation of a cell cycle inhibitor dehydrophenylahistin

    KANZAKI Hiroshi, IKEDA Banri, TAMURA Takashi, NITODA Teruhiko

    16   237 - 237   2004

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  • 昆虫キチナーゼ阻害物質生産糸状菌由来のキチナーゼ

    日本農芸化学会西日本支部,同中四国支部,日本栄養・食糧学会西日本支部,日本食品科学工学会西日本支部合同大会(口頭発表)   2003

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  • Fungal chitinases coproduced with insect chitinase inhibitors (糸状菌が昆虫キチナーゼ阻害物質とともに生産するキチナーゼ)

    第7回生体触媒化学シンポジウム (ポスター発表)   2003

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  • Enzymatic synthesis of a cell cycle inhibitor dehydrophenylahistin

    Kanzaki Hiroshi, Ikeda Banri, Morimoto Atsushi, Nitoda Teruhiko

    15   60 - 60   2003

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  • 糸状菌TNPT116-Cz株が生産する昆虫キチナーゼ阻害活性を有する多糖 2002年度日本農芸化学会大会(口頭発表)

    2002

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  • 649 Purification and characterization of dipeptidase from a cyclic dipeptide-assimilating bacterium

    Kanzaki Hiroshi, Miyoshi Kazuyuki, Nitoda Teruhiko

    14   107 - 107   2002

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  • 放線菌由来環状ジペプチド脱水素酵素系を利用するcyclo(Phe-Pro)脱水素体の合成

    神崎浩, 池田万里, 森本篤史, 仁戸田照彦

    日本農芸化学会中四国支部講演会講演要旨集   4th (Web)   2002

  • DL-Homocysteine thiolactoneからL-homocysteineへの微生物変換 (第三報)

    神崎浩, 用貝さと子, 藤田恒, 仁戸田照彦

    日本農芸化学会大会講演要旨集   2002   2002

  • 糸状菌の生産する細胞分裂阻害物質(-)-phenylahistinの培養生産

    神崎浩, 福田隆雄, 仁戸田照彦

    日本農芸化学会大会講演要旨集   2002   2002

  • Agrobacterium属細菌の凝集促進活性を有する微生物細胞外多糖の性状解析

    神崎浩, 新納愛, 仁戸田照彦

    日本農芸化学会中四国支部講演会講演要旨集   4th (Web)   2002

  • 放線菌由来cyclo(Leu-Phe)脱水素酵素の精製と諸性質の検討

    神崎浩, 森本篤史, 池田万里, 仁戸田照彦

    日本農芸化学会中四国支部講演会講演要旨集   4th (Web)   2002

  • 1 Production of Bioactive Compounds by Biosynthetic Enzymes of Dehydro Cyclic Dipeptides

    Kanzaki Hiroshi, Yanagisawa Satohiro, Akazawa Kazumi, Ikeda Banri, Morimoto Atsushi, Nitoda Teruhiko

    ( 43 )   1 - 5   2001.9

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    Cyclic dipeptides (CDPs, diketopiperazines) and their derivatives are widely distributed in nature as secondary metabolites. Although some of dehydro-CDPs are known as cell cycle inhibitors, their effective syntheses have not been reported. We found that Streptomyces albulus KO23, an albonoursin-producing actinomycete, had a biosynthetic pathway from cyclo (Leu-Phe) to albonoursin, cyclo (ΔLeu-ΔPhe) by the fed-batch culture and the resting-cell experiments. And this enzyme activity was found to be effectively extracted in the cell-free extract of this actinomycete. This is the first report for the dehydrogenation of amino acid residues at α,β-positions in CDPs. Furthermore, this enzyme system enables us to synthesize several didehydro- and tetradehydro-CDPs from the corresponding CDPs. Among dehydro-CDPs prepared, the tetradehydro-CDPs exhibited cytotoxicity, while the didehydro-CDPs had no activity, indicating that dehydrogenation at α,β-positions of both amino acid residues in CDPs is required for cytotoxicity. Based on the above results, we speculated that a tetradehydro-CDP prepared from a didehydro-CDP exhibiting cytotoxicity might be a potent cytotoxic compound. Dehydrophenylahistin synthesized by this enzyme system from (-)-phenylahistin, which was recently reported to be a new cell cycle inhibitor, exhibited 1000 times higher inhibitory activity toward the first cleavage of sea urchin embryo than (-)-phenylahistin, and thus, would be a promising lead compound for antitumor agents.

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  • 系状菌の生産する昆虫キチナーゼ阻害物質

    日本農芸化学会大会(ポスタ-発表)   2000

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  • A novel microbial enzyme system for hydrolyzing a cyclic dipeptide, cyclo(Gly-Leu)

    Kanzaki Hiroshi, Miyoshi Kazuyuki, Mizuta Naoki, Nitoda Teruhiko

    12   210 - 210   2000

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  • Enzymatic Dehydrogenation of Cyclo(L-Phe-L-Leu) to a Bioactive Derivative, Albonoursin.

    Kanzaki, H, Imura, D, Nitoda, T, Kawazu, K

    Journal of Molecular Catalysis B-Enzymatic   1999

  • 新規の環状ジペプチド脱水素酵素とその活性測定法の確立.

    神崎浩, 赤澤和美, 井村大輔, 仁戸田照彦

    岡山大学農学部学術報告   1999

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  • Microbial hyrodolysis of cyclo(Gly-Leu)

    Kanzaki Hiroshi, Mizuta Naoki, Miyoshi Kazuyuki, Nitoda Teruhiko

    11   202 - 202   1999

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  • Calophyllum inophyllumの抗HIV活性成分inophyllum A,B,C,D,E,Pの液体クロマトグラフィー・による分析法の確立

    河津 一儀, 仁戸田 照彦, 神崎 浩

    岡山大学農学部学術報告   87   13 - 16   1998.2

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  • 電気生理学的手法を用いた昆虫神経作用物質の探索

    岡山大学農学部学術報告   86   109   1997

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  • Search for Insect Neuroactive Substances Using an Electrophysiological Method

    Scientific Reports of the Faculty of Agriculture   Vol. 86,109-113   1997

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  • CHARACTERIZATION AND ANTIVIRAL FUNCTION OF SIALYLOLIGOSACCHARIDES FROM EGG-YOLK

    LR JUNEJA, M KOKETSU, T NITODA, H KAWANAMI, K SASAKI, K NAKATA, M FUJIKI, M KIM, T YAMAMOTO

    GLYCOCONJUGATE JOURNAL   10 ( 4 )   314 - 314   1993.8

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Presentations

  • Production of selective β-N-acetylglucosaminidase inhibitors by Streptomyces anulatus NBRC13369

    Mitani, Naomasa, Asao Kouhei, Kanzak Hiroshi, Nitoda Teruhiko

    The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021)  2021.12.21 

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    Event date: 2021.12.16 - 2021.12.21

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  • New insecticidal compound produced by Pochonia suchlasporia TAMA 87 in solid-state fermentation

    Syaefudin Suminto, Teruhiko Nitoda (presener)

    The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021)  2021.12.21 

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  • Microbial conversion of constituents of Eucommia ulmoides leaves into useful compounds

    2021.7.10 

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  • A new member of asteltoxin analogs with a 3,5-dimethyl-2-pyrone moiety produced by Pochonia suchlasporia TAMA 87

    Syaefudin Suminto, Eri Takatsuji, Ayako Iguchi, Hiroshi Kanzaki, Toru Okuda, Teruhiko Nitoda

    2021.3.9 

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    Event date: 2021.3.8 - 2021.3.10

    Language:English   Presentation type:Oral presentation (general)  

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  • Distribution of mammalian gut microbiota capable of converting C-glycoside mangiferin into its aglycone norathyriol

    〇Y. Uga, U. Hasanah, H. Kayaki, H. Kawakami, Y. Nishitani, H. Kuwahara, T. Nitoda, H. Kanzaki

    The 23rd Symposium of the Society of Biocatalysis Japan  2023.9.28 

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    Event date: 2023.9.28 - 2023.9.29

    Language:English   Presentation type:Poster presentation  

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  • Inhibitory sensitivity of β-N-acetylglucosaminidase from Enterococcus sp. MK26 to N,N,N-trimethyl-β-D-glucosaminium-containing compounds

    〇K. Morioka, H. Ono, M. Koide, S. Suganuma, T. Nitoda, H. Kanzaki

    The 23rd Symposium of the Society of Biocatalysis Japan  2023.9.28 

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    Event date: 2023.9.28 - 2023.9.29

    Language:English   Presentation type:Poster presentation  

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  • Pochonia suchlasporia が生産するasteltoxin 類のMS/MS 分析を用いた探索

    ○加藤陽輝, 神崎 浩, 仁戸田照彦

    2023.9.22 

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    Event date: 2023.9.21 - 2023.9.22

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Cyclo(Leu-Phe) oxidase が触媒する環状ジペプチド脱水素反応の反応初期における人工電子受容体添加の影響の定量的評価

    ○猪口慧悟, 坂口幸士朗, 仁戸田照彦, 神崎 浩

    2023.9.22 

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    Event date: 2023.9.21 - 2023.9.22

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Microbial Conversion of C-Glycoside Mangiferin into its Aglycone Norathyriol by Mammalian Intestinal Bacteria

    ○宇賀悠人, Uswatun Hasanah, 栢木宏之, 川上秀昭, 西谷洋輔, 桑原浩誠, 仁戸田照彦, 神崎浩

    2023.9.8 

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    Event date: 2023.9.8

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  • Search for chitinolytic enzyme inhibitors produced by microbobes Invited

    Hirokazu Usuki, Miho Toyo-oka, Hiroshi Kanzaki, ○Teruhiko Nitoda*

    2023.9.6 

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    Event date: 2023.9.5 - 2023.9.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

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  • 糸状菌Pochonia suchlasporia TAMA87 株の固体培養による生薬センザンリュウ二次 代謝産物の微生物変換

    ○竹本実加, 神崎 浩, 仁戸田照彦

    支部創立20 周年記念 日本農芸化学会中四国支部第64 回講演会(例会)  2023.1.21 

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    Event date: 2023.1.21

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 麹菌固体培養による杜仲葉二次代謝産物の微生物変換 (第2 報)

    ○村上 響, 奥川日菜乃, 山下秀行, 三木翔平, 仁戸田照彦, 神崎 浩

    支部創立20 周年記念 日本農芸化学会中四国支部第64 回講演会(例会)  2023.1.21 

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    Event date: 2023.1.21

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

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  • Comparison of Thai and Japanese Fermented Milk Produced by Potential Probiotic Lactic Acid Bacteria Isolated in Thailand

    ○Jirayu Jitpakdee, Hiroshi Kanzaki, Teruhiko Nitoda, Duangporn, Kantachote

    The 4th International Conference on Sustainable Agriculture and Environment (Nong Lam University Ho Chi Minh City, Vietnam, Onsite & Online Hybrid)  2022.11.18 

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    Event date: 2022.11.17 - 2022.11.19

    Language:English   Presentation type:Oral presentation (general)  

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  • Structure Analysis of Antifungal Sesterterpene ophiobilin K and Its Analogs Produced by Aspergillus ustus

    ○Nguyen T. K. Ngoc, Natthapat, Sohsomboon, Terumi Ichimiya, Teruhiko Nitoda*, Hiroshi Kanzaki

    The 4th International Conference on Sustainable Agriculture and Environment (Nong Lam University Ho Chi Minh City, Vietnam, Onsite & Online Hybrid)  2022.11.18 

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    Event date: 2022.11.17 - 2022.11.19

    Language:English   Presentation type:Oral presentation (general)  

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  • ウマ腸内細菌叢によるC-配糖体mangiferinからそのアグリコンnorathyriolへの変換

    ○宇賀悠人, 川上秀昭, 西谷洋輔, 桑原浩誠, 仁戸田照彦, 神崎浩

    日本農芸化学会2022年度中四国支部大会(第63回講演会)  2022.9.22 

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    Event date: 2022.9.21 - 2022.9.22

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Enterococcus sp. MK26株由来β-N-acetylglucosaminidaseの N,N,N-trimethyl-β-D-glucosaminium化合物に対する阻害感受性

    ○森岡京平, 小野はるか, 小出麻奈, 菅沼笙子, 仁戸田照彦, 神崎浩

    おかやまバイオアクティブ研究会 第61回シンポジウム  2022.9.20 

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    Event date: 2022.9.20

    Language:Japanese   Presentation type:Poster presentation  

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  • バイオサーファクタント・サーファクチンの自己集合特性への対カチオン種の違いによる影響

    ○柳澤恵広, 柳澤恵広, 平敏彰, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部第62回講演会講演会(例会) 島根大学(オンライン開催)  2022.6.4 

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    Event date: 2022.6.4

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Effect of steaming on Aspergillus solid state fermentation of olive leaves

    2022.3.16 

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    Event date: 2022.3.15 - 2022.3.18

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Effect of hot water pretreatment on Aspergillus solid state fermentation of wine pomace

    2022.3.16 

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    Event date: 2022.3.15 - 2022.3.18

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Analysis of MS/MS fragmentation patterns for search of new asteltoxin analogs with a unique α-pyrone moiety

    三谷尚大, 神崎浩, 仁戸田照彦

    2022.3.8 

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    Event date: 2022.3.7 - 2022.3.9

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  • Cyclo(Leu-Phe)oxidaseの幅広い基質特異性の定量的評価-天然の電子受容体を用いた活性測定と人工の電子受容体を用いた活性測定の比較-

    ○坂口幸士朗, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部 第61回支部講演会(例会) 高知大学(オンライン)  2022.1.22 

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    Event date: 2022.1.22

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  • Production of selective β-N-acetylglucosaminidase inhibitors by Streptomyces anulatus NBRC13369 International conference

    Naomasa Mitani

    2020 International Chemical Congress of Pacific Basin Societies (Pacifichem 2020)  2021.12.21  Pacifichem, Inc. and Pacifichem 2021 Organizing Committee

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    Event date: 2021.12.16 - 2021.12.21

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  • New insecticidal compound produced by Pochonia suchlasporia TAMA 87 in solid-state fermentation International conference

    Syaefudin Suminto (Oral presentation was done by Teruhiko Nitoda)

    2020 International Chemical Congress of Pacific Basin Societies (Pacifichem 2020)  2021.12.20  Pacifichem, Inc. and Pacifichem 2021 Organizing Committee

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    Event date: 2021.12.16 - 2021.12.21

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • Quantitative evaluation of the substrate specificity of cyclo(Leu-Phe) oxidase toward various cyclodipeptides International conference

    Koshiro Sakaguchi

    2020 International Chemical Congress of Pacific Basin Societies (Pacifichem 2020)  2021.12.20  Pacifichem, Inc. and Pacifichem 2021 Organizing Committee

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    Event date: 2021.12.16 - 2021.12.21

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  • Quantitative evaluation of the substrate specificity of cyclo(Leu-Phe) oxidase toward various cyclodipeptides

    Koshiro Sakaguchi, Kenta Konishi, Teruhiko Nitoda, Hiroshi Kanzaki

    The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021)  2021.12.20 

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    Event date: 2021.12.16 - 2021.12.21

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  • High functionalization of Japanese wine pomace constituents by Aspergillus solid-state fermentation International conference

    Hinano Okukawa

    2020 International Chemical Congress of Pacific Basin Societies (Pacifichem 2020)  2021.12.18  Pacifichem, Inc. and Pacifichem 2021 Organizing Committee

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    Event date: 2021.12.16 - 2021.12.21

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • High functionalization of olive leaves constituent by Aspergillus solid-state fermentation International conference

    Atsuko Hashimoto

    2020 International Chemical Congress of Pacific Basin Societies (Pacifichem 2020)  2021.12.18  Pacifichem, Inc. and Pacifichem 2021 Organizing Committee

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    Event date: 2021.12.16 - 2021.12.21

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • High functionalization of Japanese wine pomace constituents by Aspergillus solid-state fermentation

    Okukawa, Hinano, Yamashita Hideyuki, Utida Mami, Miki Shouhei, Nakagawa Takuro, Nitda, Teruhiko, Kanzaki Hiroshi

    The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021)  2021.12.18 

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    Event date: 2021.12.16 - 2021.12.21

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  • High functionalization of olive leaves constituent by Aspergillus solid-state fermentation

    Atsuko Hashimoto, Komaki Kurihara, Mariko Koga, Ayaka Takatsu, Teruhiko Nitoda, Moriya Hisao, Hiroshi Kanzaki

    The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021)  2021.12.18 

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    Event date: 2021.12.16 - 2021.12.21

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  • 麹菌固体培養によるオリーブ葉成分の微生物変換

    ○橋本敦子, 奥川日菜乃, 三宅剛史, 伊藤一成, 谷野有佳, 山下秀行, 内田真美, 三木翔平, 吉田靖弘, 徐 恵美, 菊地敬一, 仁戸田照彦, 神崎浩

    おかやまバイオアクティブ研究会 59回シンポジウム オンライン開催(岡山市)  2021.10.27 

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    Event date: 2021.10.27

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  • 麹菌固体培養によるオリーブ葉成分の微生物変換

    〇橋本敦子 1 奥川日菜乃 1 三宅剛史 2 伊藤一成 2 谷野有佳 2 山下秀行 3 内田真美 3 三木翔平 3 吉田靖弘 4 徐 恵美 4 菊地敬一 4 仁戸田照彦 1 神崎浩 1

    おかやまバイオアクティブ研究会 59回シンポジウム  2021.10.27  おかやまバイオアクティブ研究会

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    Event date: 2021.10.27

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン開催(岡山市)   Country:Japan  

  • 麹菌固体培養による日本ワインパミス成分の高機能化(第2報)

    ○奥川日菜乃,橋本敦子,三宅剛史1,伊藤一成1,谷野有佳1,山下秀行2,中川拓郎2,

    日本農芸化学会西日本・中四国・関西支部 2021年度合同鹿児島大会  2021.9.25  日本農芸化学会西日本・中四国・関西支部

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    Event date: 2021.9.24 - 2021.9.25

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン開催(鹿児島市)   Country:Japan  

  • 麹菌固体培養による日本ワインパミス成分の高機能化(第2報)

    ○奥川日菜乃, 橋本敦子, 三宅剛史, 伊藤一成, 谷野有佳, 山下秀行, 中川拓郎

    日本農芸化学会西日本・中四国・関西支部 2021年度合同鹿児島大会 オンライン開催(鹿児島市)  2021.9.25 

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    Event date: 2021.9.24 - 2021.9.25

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  • 麹菌固体培養による 杜仲葉二次代謝産物の微生物変換

    ○村上響,奥川日菜乃,山下秀行 1 ,三木翔平 1 仁戸田 照彦,神崎 浩

    日本農芸化学会中四国支部 第59回支部講演会(例会)  2021.6.12  日本農芸化学会中四国支部

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    Event date: 2021.6.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン開催(広島大学大学院統合生命科学研究科)   Country:Japan  

  • 麹菌固体培養による杜仲葉二次代謝産物の微生物変換

    ○村上響, 奥川日菜乃, 山下秀行, 三木翔平, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部 第59回支部講演会(例会)広島大学(オンライン)  2021.6.12 

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    Event date: 2021.6.12

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  • 麹菌固体培養による 杜仲葉二次代謝産物の微生物変換

    ○村上響, 奥川日菜乃, 山下秀行, 三木翔平, 仁戸田 照彦, 神崎 浩

    日本農芸化学会中四国支部 第59回支部講演会(例会) オンライン開催(広島大学大学院統合生命科学研究科)  2021.6.12 

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  • 麹菌固体培養による日本ワインパミス成分の高機能化

    ○奥川 日菜乃1,橋本 敦子1,三宅 剛史2,伊藤 一成2, 谷野 有佳2,山下 秀行3,中川 拓郎3,平野 幸司4, 仁戸田 照彦1,神崎 浩1

    日本農芸化学会2021年度大会  2021.3.20  日本農芸化学会

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    Event date: 2021.3.18 - 2021.3.21

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Zoom によるオンライン開催(仙台市)   Country:Japan  

  • 麹菌固体培養によるオリーブ葉成分の高機能化

    ○橋本 敦子1,奥川 日菜乃1,三宅 剛史2,伊藤 一成2, 谷野 有佳2,山下 秀行3,内田 真美3,三木 翔平3,吉田 靖弘4, 徐 恵美4,菊地 敬一4,仁戸田 照彦1,神崎 浩1

    日本農芸化学会2021年度大会  2021.3.20  日本農芸化学会

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    Event date: 2021.3.18 - 2021.3.21

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Zoom によるオンライン開催(仙台市)   Country:Japan  

  • 麹菌固体培養による日本ワインパミス成分の高機能化

    ○奥川 日菜乃, 橋本 敦子, 三宅 剛史, 伊藤 一成, 谷野 有佳, 山下 秀行, 中川 拓郎, 平野 幸司, 仁戸田 照彦, 神崎 浩

    日本農芸化学会2021年度大会 Zoom によるオンライン開催(仙台市)  2021.3.20 

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    Event date: 2021.3.18 - 2021.3.21

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  • 麹菌固体培養によるオリーブ葉成分の高機能化

    ○橋本 敦子, 奥川 日菜乃, 三宅 剛史, 伊藤 一成, 谷野 有佳, 山下 秀行, 内田 真美, 三木 翔平, 吉田 靖弘, 徐 恵美, 菊地 敬一, 仁戸田 照彦, 神崎 浩

    日本農芸化学会2021年度大会 Zoom によるオンライン開催(仙台市)  2021.3.20 

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    Event date: 2021.3.18 - 2021.3.21

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  • A new member of asteltoxin analogs with a 3,5-dimethyl-2-pyrone moiety produced by Pochonia suchlasporia TAMA 87

    ○ Syaefudin Suminto1 , Eri Takatsuji1 , Ayako Iguchi1, Hiroshi Kanzaki1, Toru Okuda2, Teruhiko Nitoda1

    2021.3.9 

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    Event date: 2021.3.8 - 2021.3.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Penicillium aurantiogriseumが触媒するAspergillus ustus代謝物の新規フロイソキノリンアルカロイドへの変換反応

    〇山田光代, 齊 藤 太 樹,小川凌太,仁戸田照彦,神崎浩

    日本農芸化学会中四国支部 第58回講演会(例会)  2021.1.23  日本農芸化学会中四国支部

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    Event date: 2021.1.23

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン開催(香川大学)   Country:Japan  

  • Penicillium aurantiogriseumが触媒するAspergillus ustus代謝物の新規フロイソキノリンアルカロイドへの変換反応

    ○山田光代, 齊 藤 太 樹, 小川凌太, 仁戸田照彦, 神崎浩

    日本農芸化学会中四国支部 第58回講演会(例会) オンライン開催(香川大学)  2021.1.23 

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    Event date: 2021.1.23

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  • Quantitative evaluation of the substrate specificity of cyclo(Leu-Phe)oxidase toward various cyclodipeptides

    〇 Koshiro Sakaguchi, Kenta Konishi, Teruhiko Nitoda, Hiroshi Kanzaki

    2020.12.15 

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    Event date: 2020.12.15

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Quantitative evaluation of the substrate specificity of cyclo(Leu-Phe)oxidase toward various cyclodipeptides

    Koshiro Sakaguchi, Kenta Konishi, Teruhiko Nitoda, Hiroshi Kanzaki

    2020.12.15 

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  • 2種の糸状菌、Aspergillus ustusとPenicillium aurantiogriseumの組み合わせにより生産される新規フロイソキノリンアルカロイドの生産条件検討

    ○山田 光代,齊藤 太樹,小川 凌太,仁戸田 照彦, 神崎 浩

    日本生物工学会西日本支部大会(第5回講演会)  2020.11.14  日本生物工学会西日本支部

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    Event date: 2020.11.14

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山理科大学(岡山市)   Country:Japan  

  • 2種の糸状菌、Aspergillus ustusとPenicillium aurantiogriseumの組み合わせにより生産される新規フロイソキノリンアルカロイドの生産条件検討

    ○山田 光代, 齊藤 太樹, 小川 凌太, 仁戸田 照彦, 神崎 浩

    日本生物工学会西日本支部大会(第5回講演会) 岡山理科大学(岡山市) にて開催  2020.11.14 

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  • Bioconversion of C-glycoside mangiferin into its aglycone norathyriol under aerobic conditions by a novel mouse intestinal bacterium

    ○Uswatun Hasanah, Kasumi Miki, Hideaki Kawakami1, Yosuke Nishitani1, Hiroshige Kuwahara1, Teruhiko Nitoda, Hiroshi Kanzaki

    2020.9.18 

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    Event date: 2020.9.17 - 2020.9.18

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Bioconversion of C-glycoside mangiferin into its aglycone norathyriol under aerobic conditions by a novel mouse intestinal bacterium

    ○Uswatun Hasanah, Kasumi Miki, Hideaki Kawakami, Yosuke Nishitani, Hiroshige Kuwahara, Teruhiko Nitoda, Hiroshi Kanzaki

    2020.9.18 

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    Event date: 2020.9.17 - 2020.9.18

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  • Pochonia suchlasporia の固体培養により生産される糸状菌胞子発芽阻害物質 (第2報)

    ○片岡智範,神崎浩,仁戸田照彦

    日本農芸化学会中四国支部第56回講演会(例会)  2020.1.25  日本農芸化学会中四国支部

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    Event date: 2020.1.25

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛媛大学 城北キャンハ?ス  

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  • An Insecticidal Compound Produced by Pochonia suchlasporia var. suchlasporia TAMA 87

    Syaefudin Suminto, Eri Takatsuji, Ayako Iguchi, Toru Okuda, Hiroshi Kanzaki, Teruhiko Nitoda

    2019.11.9 

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    Event date: 2019.11.8 - 2019.11.9

    Language:English   Presentation type:Oral presentation (general)  

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  • Novel Furo-isoquinoline Alkaloids Produced by Co-cultivation of Aspergillus ustus with Penicillium aurantiogriseum

    The 21st Biocatalysis Symposium of Japan  2019.8.29 

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    Event date: 2019.8.29

    Language:English   Presentation type:Poster presentation  

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  • Aspergillus ustus とPenicillium aurantiogriseum の組み合わせ培養により生産される新規フロイソキノリンアルカロイド

    〇山田光代, 齊藤太樹, 小川凌太, 仁戸田照彦, 神崎浩

    おかやまバイオアクティブ研究会 第55回シンポジウム  2019.7.9  おかやまバイオアクティブ研究会

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    Event date: 2019.7.9

    Language:English   Presentation type:Poster presentation  

    Venue:岡山大学創立 岡山大学創立 岡山大学創立 五十周年 十周年 記念館 記念館  

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  • Aspergillus ustus とPenicillium aurantiogriseum の組み合わせ培養により生産される新規フロイソキノリンアルカロイドの絶対立体配置の決定

    ○山田光代, 齊藤太樹, 小川凌太, 仁戸田照彦, 神崎 浩

    日本農芸化学会 中四国支部 第54回講演会(例会)  2019.6.1  日本農芸化学会 中四国支部

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    Event date: 2019.6.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山理科大学 岡山キャンパス  

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  • Pochonia suchlasporiaの固体培養により生産される糸状菌胞子発芽阻害物質

    ○片岡智範, 神崎 浩, 仁戸田照彦

    日本農芸化学会 2019 年度(平成31 年度)大会  2019.3.26  日本農芸化学会

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    Event date: 2019.3.26

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京農業大学 世田谷キャンパス  

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  • 過酸化水素定量を利用したCyclo(Leu-Phe) oxidaseの活性測定法の確立と基質特異性検討

    ○小西健太, 仁戸田照彦, 神崎浩

    日本農芸化学会 中四国支部第53回講演会(例会)  2019.1.26  日本農芸化学会 中四国支部

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    Event date: 2019.1.26

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:高知大学物部キャンパス  

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  • Search and identification of enzymes from Saccharomyces cerevisiae catalyzing the reduction of olive leaf secondary metabolite, 3-4-dihydroxyphenylethanol-elenolic acid

    The 20th Biocatalysis Symposium of Japan 

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    Event date: 2018.12.12

    Language:English   Presentation type:Poster presentation  

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  • Identification of enzymes derived from Saccharomyces cerevisiae catalyzing the reaction of olive leaf secondary metabolite, 3,4-dihydroxyphenylethanol-elenolic acid to reduced 3,4-dihydroxyphenylethanol-elenolic acid International conference

    Kana Matsukawa, Saori Makio, Teruhiko Nitoda, Hisao Moriya, and Hiroshi Kanzaki

    3rd International Conference on Biologically Active Substances Bioactive Okayama 2018  おかやまバイオアクティブ研究会、(公財)岡山県産業振興財団

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    Event date: 2018.10.16

    Language:English   Presentation type:Poster presentation  

    Venue:岡山国際交流センター  

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  • Isolation of p-nitrophenyl N-acetyl-β-D-glucosaminide assimilating bacteria and their β-N-acetylglucosaminidase sensitivity to p-nitrophenyl N, N, N-trimethyl β-D-glucosaminium iodide International conference

    Mana Koide, Shoko Suganuma, Teruhiko Nitoda, and Hiroshi Kanzaki

    3rd International Conference on Biologically Active Substances Bioactive Okayama 2018  おかやまバイオアクティブ研究会、(公財)岡山県産業振興財団

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    Event date: 2018.10.16

    Language:English   Presentation type:Poster presentation  

    Venue:岡山国際交流センター  

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  • Saccharomyces cerevisiae由来alcohol dehydrogenase 6は3,4-dihydroxyphenylethanol-elenolic acidの還元を触媒する

    〇松川加奈,巻尾沙織,仁戸田照彦,守屋央郎,神崎 浩

    日本農芸化学会 中四国支部大会(第52回大会)  日本農芸化学会 中四国支部

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    Event date: 2018.9.21

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:島根大学松江キャンパス  

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  • Comparative substrate specificity study of transglucosylation of L-ascorbic acid catalyzed by three p-nitrophenyl β-D-glucopyranoside hydrolases from Penicillium multicolor

    Mana KOIDE, Shoko SUGANUMA, Teruhiko NITODA, Hiroshi KANZAKI

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    Event date: 2018.3.15 - 2018.3.18

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • The uniqueness of antimicrobial spectrum of ophiobolin K produced by Aspergillus ustus

    Natthapat SOHSOMBOON, Teruhiko NITODA, Hiroshi KANZAKI

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    Event date: 2018.3.15 - 2018.3.18

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Novel isoquinoline alkaloid produced by co-cultivation of Aspergillus ustus with Penicillium aurantiogriseum

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    Event date: 2016.3.27 - 2016.3.30

    Language:Japanese   Presentation type:Poster presentation  

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  • Kinetic study of β-glucosidases with different substrate- and regio-specificities in transglycosylation of L-ascorbic acid

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    Event date: 2016.3.27 - 2016.3.30

    Language:Japanese   Presentation type:Poster presentation  

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  • 放線菌由来cyclo(Leu-Phe) oxidaseの脱水素反応における電子伝達に関する検討

    ○間野なお美,仁戸田照彦,神崎浩

    日本農芸化学会中四国第44回講演会(支部例会)  日本農芸化学会中四国支部

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    Event date: 2016.1.23

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山県立大  

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  • β-N-Acetylglucosaminidase 阻害物質pochonicine のアセチル化によるNOE 相関への影響

    ○江本啓輔,奥田徹,神崎浩,仁戸田照彦

    日本農芸化学会中四国第44回講演会(支部例会)  日本農芸化学会中四国支部

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    Event date: 2016.1.23

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山県立大  

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  • Cyclo(Leu-Phe) oxidaseを用いた酵素変換法により見出される Mucor petrinsularisの生産する環状ジペプチド

    ○徳島將光,高橋佳子,福田 優,仁戸田照彦,神崎 浩

    日本農芸化学会中四国第44回講演会(支部例会)  日本農芸化学会中四国支部

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    Event date: 2016.1.23

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山県立大  

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  • Screening for cyclic dipeptide-producing fungi using enzymatic conversion by cyclo(Leu-Phe) oxidase International conference

    Masamitsu Tokushima, Keiko Takahashi*, Yuu Fukuda, Teruhiko Nitoda and Hiroshi Kanzaki

    2015 環太平洋国際化学会議 (PACIFICHEM 2015)  日本、アメリカ、カナダ、オーストラリア、ニュージーランド、韓国、中国の7 化学会

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    Event date: 2015.12.15 - 2015.12.20

    Language:English   Presentation type:Poster presentation  

    Venue:ハワイ ホノルル  

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  • Insecticidal and growth inhibitory activities of metabolites of fungal strains producing β-N-acetylglucosaminidase inhibitors against larvae of sheep blowfly International conference

    Takatsuji Eri*, Okuda Toru , Kanzaki Hiroshi and Nitoda Teruhiko

    2015 環太平洋国際化学会議 (PACIFICHEM 2015)  日本、アメリカ、カナダ、オーストラリア、ニュージーランド、韓国、中国の7 化学会

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    Event date: 2015.12.15 - 2015.12.20

    Language:English   Presentation type:Poster presentation  

    Venue:ハワイ ホノルル  

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  • Hydrolysis of a baker’s yeast reduction product of oleuropein aglycon from olive leaf extract International conference

    Mariko Koga*, Ayaka Takatsu, Megumi Jyo, Keiichi Kikuchi, Teruhiko Nitoda, and Hiroshi Kanzaki

    2015 環太平洋国際化学会議 (PACIFICHEM 2015)  日本、アメリカ、カナダ、オーストラリア、ニュージーランド、韓国、中国の7 化学会

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    Event date: 2015.12.15 - 2015.12.20

    Language:English   Presentation type:Poster presentation  

    Venue:ハワイ ホノルル  

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  • Availability of woody biomass degraded by mushrooms as ingredient of fermented total mixed ration for feeding dairy cattle International conference

    Nagatani Naoya*, Kojima Takeshi, Nishino Naoki , Tokimoto Keisuke , Nagao Shinichiro , Nitoda Teruhiko and Kanzaki Hiroshi

    2015 環太平洋国際化学会議 (PACIFICHEM 2015)  日本、アメリカ、カナダ、オーストラリア、ニュージーランド、韓国、中国の7 化学会

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    Event date: 2015.12.15 - 2015.12.20

    Language:English   Presentation type:Poster presentation  

    Venue:ハワイ ホノルル  

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  • A comparative study of transglucosylation and hydrolysis activities of b-glucosidases from different organisms International conference

    Shoko Suganuma*, Miki Terasaka, Yumi Hayakawa, Teruhiko Nitoda and Hiroshi Kanzaki

    2015 環太平洋国際化学会議 (PACIFICHEM 2015)  日本、アメリカ、カナダ、オーストラリア、ニュージーランド、韓国、中国の7 化学会

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    Event date: 2015.12.15 - 2015.12.20

    Language:English   Presentation type:Poster presentation  

    Venue:ハワイ ホノルル  

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  • Screening of microorganisms from flowers for high reducing ability of the aldehyde group of oleuropein aglycon International conference

    Saori Makio*, Tsuyoshi Norimatsu, Megumi Jyo, Keiichi Kikuchi, Teruhiko Nitoda, Hiroshi Kanzaki

    2015 環太平洋国際化学会議 (PACIFICHEM 2015)  日本、アメリカ、カナダ、オーストラリア、ニュージーランド、韓国、中国の7 化学会

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    Event date: 2015.12.15 - 2015.12.20

    Language:English   Presentation type:Poster presentation  

    Venue:ハワイ ホノルル  

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  • GC-MS analysis of the beta-N-acetylglucosaminidase inhibitor pochonicine and its analogs produced by a fungal strain International conference

    Keisuke Emoto*, Yuichi Mushiake*, Aya Tsuchida, Toru Okuda, Hiroshi Kanzaki, Teruhiko Nitoda

    2015 環太平洋国際化学会議 (PACIFICHEM 2015)  日本、アメリカ、カナダ、オーストラリア、ニュージーランド、韓国、中国の7 化学会

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    Event date: 2015.12.15 - 2015.12.20

    Language:English   Presentation type:Poster presentation  

    Venue:ハワイ ホノルル  

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  • β-N-Acetylglucosaminidase 阻害物質生産糸状菌が生産する 昆虫成長制御物質

    ○高辻笑理 (博士前期2 年生),奥田 徹,神崎 浩,仁戸田照彦

    おかやまバイオアクティブ研究会第48回シンポジウム岡山県農林水産総合センター生物科学研究所(RIBS Okayama)および 第15回RIBSバイオサイエンスシンポジウム  (公財)岡山県産業振興財団/ おかやまバイオアクティブ研究会/ 岡山県農林水産総合センター生物科学研究所

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    Event date: 2015.11.14

    Presentation type:Poster presentation  

    Venue:岡山県天神山文化プラザ  

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  • Penicillium multicolorが生産する2種類のβ-グルコシダーゼの基質特異性に関する研究

    ○菅沼笙子,寺坂美紀,仁戸田照彦,神崎 浩

    日本農芸化学会中四国・西日本支部合同大会  日本農芸化学会

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    Event date: 2015.9.17 - 2015.9.18

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛媛大学農学部(松山市) 発表日20150918  

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  • オリーブ葉二次代謝産物oleuropein aglyconを効率的に還元する微生物の探索

    〇巻尾沙織,乗松 毅,徐 恵美,菊地敬一,仁戸田照彦,神崎 浩

    日本農芸化学会中四国・西日本支部合同大会  日本農芸化学会

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    Event date: 2015.9.17 - 2015.9.18

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛媛大学農学部(松山市) 発表日20150918  

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  • 糸状菌が生産するβ-N-Acetylglucosaminidase阻害剤pochonicineの6, 7-ジデオキシ類縁体

    〇虫明優一,土田 彩,奥田 徹,神崎 浩,仁戸田照彦

    日本農芸化学会中四国・西日本支部合同大会  日本農芸化学会

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    Event date: 2015.9.17 - 2015.9.18

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛媛大学農学部(松山市) 発表日20150918  

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  • 食用キノコ処理木質バイオマスの家畜飼料素材としての利用

    ○永谷直哉,小島 豪,柏野泰章,長尾伸一郎,時本景亮,西野直樹,仁戸田照彦,神崎 浩

    日本農芸化学会中四国・西日本支部合同大会  日本農芸化学会

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    Event date: 2015.9.17 - 2015.9.18

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛媛大学農学部(松山市) 発表日20150918  

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  • Isolation and structural analysis of novel analogs of the β-N-acetylglucosaminidase inhibitor TMG-chitotriomycin

    Kohei ASAO, Hiroshi KANZAKI, Teruhiko NITODA

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    Event date: 2015.3.26 - 2015.3.29

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Novel isoquinoline alkaloid from Aspergillus ustus

    Taiki SAITO, Teruhiko NITODA, Hiroshi KANZAKI

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    Event date: 2015.3.26 - 2015.3.29

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Reduced oleuropein aglyconからhydroxytyrosolとreduced elenolic acidへの変換

    ○古賀まり子,高津綾香,原田嘉広,仁戸田照彦,神崎浩,徐恵美,菊地敬一

    日本農芸化学会中四国第41回講演会(支部例会)  日本農芸化学会中四国支部

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    Event date: 2015.1.24

    Presentation type:Oral presentation (general)  

    Venue:水産大学校(山口県下関市)  

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  • ヒト腸内細菌を用いたC-配糖体mangiferinからそのアグリコンnorathyriolへの効率的変換

    ○角南里美,仁戸田照彦,神崎浩,桑原浩誠,奥田洋

    日本農芸化学会中四国第41回講演会(支部例会)  日本農芸化学会中四国支部

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    Event date: 2015.1.24

    Presentation type:Oral presentation (general)  

    Venue:水産大学校(山口県下関市)  

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  • オリーブ葉二次代謝産物oleuropein aglyconからreduced oleuropein aglyconへの反応を触媒するSaccharomyces cerevisiae由来酵素の同定

    ○森吉弘,仁戸田照彦,神崎浩,守屋央郎

    日本農芸化学会中四国第41回講演会(支部例会)  日本農芸化学会中四国支部

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    Event date: 2015.1.24

    Presentation type:Oral presentation (general)  

    Venue:水産大学校(山口県下関市)  

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  • Human intestinal bacteria-catalyzed effective conversion of C- glucoside mangiferin to its bioactive aglycone norathyriol International conference

    Satomi Sunami, Hiroshige Kuwahara, Yo Okuda, Teruhiko Nitoda and Hiroshi Kanzaki

    Active Enzyme Molecule 2014 

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    Event date: 2014.12.17 - 2014.12.19

    Presentation type:Poster presentation  

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  • β-N-Acetylglucosaminidase 阻害物質生産糸状菌が生産する昆虫成長制御物質

    ○?辻笑理,奥田徹1,神崎浩,仁戸田照彦

    日本農芸化学会中四国支部大会 (第40回講演会)  日本農芸化学会中四国支部

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    Event date: 2014.9.26 - 2014.9.27

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:徳島大学常三島キャンパス  

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  • 4 種の抗酸化試験によるoleuropein aglycon のパン酵母還元生成物およびその関連化合物の評価

    高津綾香,○古賀まり子,三宅剛史1,徐恵美2,菊地敬一2,仁戸田照彦,神崎浩

    日本農芸化学会中四国支部大会 (第40回講演会)  日本農芸化学会中四国支部

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    Event date: 2014.9.26 - 2014.9.27

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:徳島大学常三島キャンパス  

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  • A comparative study of hydrolysis and transglucosylation activities of β-glucosidases from different sources

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    Event date: 2014.3.27 - 2014.3.30

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Microbial conversion of olive secondary metabolites by solid-state culture of Aspergillus niger

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    Event date: 2014.3.27 - 2014.3.30

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Aspergillus ustusとAspergillus repensとの組み合わせ培養で観察されるAspergillus repensの生育阻害

    ○高岡晶美,仁戸田照彦,神崎浩

    日本農芸化学会関西・中四国・西日本支部および日本ビタミン学会近畿・中国四国・九州沖縄地区合同大会2013年度合同広島大会  日本農芸化学会関西・中四国・西日本支部および日本ビタミン学会

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    Event date: 2013.9.5 - 2013.9.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:県立広島大学 広島キャンパス 教育研究棟2(〒734-8558 広島市南区宇品東1-1-71)  

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  • Aspergillus ustusとPenicillium aurantiogriseumとの組み合わせ培養による単独培養で検出されない化合物の生産

    ○齊藤太樹,小坂亜弓,仁戸田照彦,神崎浩

    日本農芸化学会関西・中四国・西日本支部および日本ビタミン学会近畿・中国四国・九州沖縄地区合同大会2013年度合同広島大会  日本農芸化学会関西・中四国・西日本支部および日本ビタミン学会

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    Event date: 2013.9.5 - 2013.9.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:県立広島大学 広島キャンパス 教育研究棟2(〒734-8558 広島市南区宇品東1-1-71)  

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  • コロイダルキチンによる放線菌由来キチン分解酵素阻害物質の 培養生産性への影響

    ○長谷井拓真,淺尾昂平,神崎浩,仁戸田照彦

    日本農芸化学会関西・中四国・西日本支部および日本ビタミン学会近畿・中国四国・九州沖縄地区合同大会2013年度合同広島大会  日本農芸化学会関西・中四国・西日本支部および日本ビタミン学会

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    Event date: 2013.9.5 - 2013.9.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:県立広島大学 広島キャンパス 教育研究棟2(〒734-8558 広島市南区宇品東1-1-71)  

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  • β-N-Acetylglucosaminidase阻害物質TMG-chitotriomycinの関連化合物 の探索

    ○淺尾昂平 (博士前期 1回生),長谷井拓真,神崎 浩,仁戸田照彦

    おかやまバイオアクティブ研究会シンポジウム  おかやまバイオアクティブ研究会

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    Event date: 2013.6.15

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:中国学園大学 新1号館1階(岡山市北区庭瀬83)  

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  • β-N-Acetylglucosaminidase阻害物質TMG-chitotriomycinの関連化合物の探索

    ○淺尾昂平,神崎 浩,仁戸田照彦

    日本農芸化学会中四国支部第36回講演会  日本農芸化学会中四国支部

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    Event date: 2013.6.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:島根大学生物資源科学部  

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  • 糸状菌Paecilomyces sp.F30株の生産する β-N-acetylglucosaminidase阻害物質

    戎義子 ,土田彩,奥田徹,神崎 浩, 仁戸田照彦

    日本農芸化学会中四国支部第35回講演会  日本農芸化学会中四国支部

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    Event date: 2013.1.26

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:高知大学農学部  

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  • 放線菌由来cyclo (Leu-Phe) oxidaseの 凝集性と可溶化の試み

    ○相澤ゆかり,仁戸田照彦,神崎浩

    日本農芸化学会中四国支部第35回講演会  日本農芸化学会中四国支部

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    Event date: 2013.1.26

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:高知大学農学部  

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  • Enzymatic synthesis of 6-O-(β-D-glucopyranosyl)ascorbic acid using the GH family 3 β-glucosidase from Aspergillus niger catalyzing regiospecific transglucosylation of ascorbic acid

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    Event date: 2012.11.29 - 2012.11.30

    Language:English   Presentation type:Poster presentation  

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  • β-N-Acetylglucosaminidase inhibitors produced by fungus Paecilomyces sp. F30

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    Event date: 2012.11.29 - 2012.11.30

    Language:English   Presentation type:Poster presentation  

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  • ヒノキ木粉の生分解性を向上させる白色腐朽菌の探索

    小島豪,光永均,時本景亮,西野直樹,仁戸田照彦,神崎浩

    日本農芸化学会中四国支部第34回講演会  日本農芸化学会中四国支部

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    Event date: 2012.9.21 - 2012.9.22

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:山口大学工学部常盤台キャンパス(宇部市)  

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  • β-Glucosidase from Aspergillus niger catalyzing transglucosylation of ascorbic acid to produce 6-O-(β-D-glucopyranosyl)ascorbic acid International conference

    Bioactive Okayama2012(BAO2012) 

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    Event date: 2012.9.13 - 2012.9.14

    Language:English   Presentation type:Poster presentation  

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  • Growth amelioration of NaCl-stressed rice (Oryza sativa) by selected phototrophic purple nonsulfur bacteria International conference

    Bioactive Okayama2012(BAO2012) 

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    Event date: 2012.9.13 - 2012.9.14

    Language:English   Presentation type:Poster presentation  

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  • GC-MS analysis of the β-N-acetylglucosaminidase inhibitor pochonicine and its analogs produced by a fungal strain International conference

    Bioactive Okayama2012(BAO2012) 

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    Event date: 2012.9.13 - 2012.9.14

    Language:English   Presentation type:Poster presentation  

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  • β-N-Acetylglucosaminidase阻害剤pochonicineのGC-MS分析及び新規類縁体の確認

    ○土田彩,安井あゆみ,奥田徹,神崎浩,仁戸田照彦

    日本農芸化学会中四国支部第33回講演会  日本農芸化学会中四国支部

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    Event date: 2012.6.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛媛大学農学部(愛媛県松山市)  

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  • アスコルビン酸の位置特異的な配糖化を触媒するAspergillus niger由来β-グルコシダーゼを用いたアスコルビン酸6βグルコシドの合成

    ○寺坂美紀,早川有美,仁戸田照彦,神崎浩

    日本農芸化学会中四国支部第33回講演会  日本農芸化学会中四国支部

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    Event date: 2012.6.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛媛大学農学部(愛媛県松山市)  

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  • 発酵食品微生物由来環状ジペプチド類と関連化合物の抗酸化活性評価

    ○高津 綾香、福田 優、張 曼、仁戸田 照彦、神崎 浩

    日本農芸化学会2012年度大会  日本農芸化学会

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    Event date: 2012.3.22 - 2012.3.26

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都女子大学(京都市)  

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  • Cyclo (Leu-Phe)oxidase変換反応を受ける糸状菌由来二次代謝産物の検出

    ○高橋 佳子、福田 優、仁戸田 照彦、神崎 浩

    日本農芸化学会2012年度大会  日本農芸化学会

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    Event date: 2012.3.22 - 2012.3.26

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都女子大学(京都市)  

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  • Inhibitory selectivity of β-N-acetylglucosaminidase inhibitor TMG-chitotriomycin

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    Event date: 2012.3.14 - 2012.3.16

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 鰹節生産糸状菌が生産する抗酸化活性物質

    ○高橋佳子,高津綾香,福田 優,土居幹冶,小山 大,仁戸田照彦, 神崎 浩

    平成23年度日本農芸化学会西日本支部、中四国支部合同大会  日本農芸化学会西日本支部、中四国支部

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    Event date: 2011.9.17 - 2011.9.18

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:宮崎観光ホテル、宮崎大学教育文化学部(宮崎市)  

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  • 微生物変換で得られるoleuropein aglyconの還元型化合物およびその関連化合物の抗酸化活性評価

    ○高津綾香,秋久恵里佳,吉田靖弘,徐恵美,仁戸田照彦,神崎浩

    平成23年度日本農芸化学会西日本支部、中四国支部合同大会  日本農芸化学会西日本支部、中四国支部

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    Event date: 2011.9.17 - 2011.9.18

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:宮崎観光ホテル、宮崎大学教育文化学部(宮崎市)  

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  • O-12 Detection of fermented food microorganisms-producing bioactive cyclic dipeptides by enzymatic conversion-based method International conference

    International Union of Microbiological Societies 2011 Congress 

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    Event date: 2011.9.6 - 2011.9.10

    Language:English   Presentation type:Oral presentation (general)  

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  • P-AM08-22 Detection of fermented food microorganisms-producing bioactive cyclic dipeptides by enzymatic conversion-based method International conference

    International Union of Microbiological Societies 2011 Congress 

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    Event date: 2011.9.6 - 2011.9.10

    Language:English   Presentation type:Poster presentation  

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  • Inhibitory selectivity of β-N-acetylglucosaminidase inhibitor TMG-chitotriomycin produced by Streptomyces anulatus International conference

    International Union of Microbiological Societies 2011 Congress 

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    Event date: 2011.9.6 - 2011.9.10

    Language:English   Presentation type:Poster presentation  

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  • Organic compounds which specifically inhibit the activity of chitinolytic enzymes

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    Event date: 2011.6.29 - 2011.7.1

    Language:Japanese   Presentation type:Poster presentation  

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  • Organic compounds which specifically inhibit the activity of chitinolytic enzymes

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    Event date: 2011.6.29 - 2011.7.1

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • MS/MSフラグメンテーションプロファイルを指標としたTMG-chitotriomycin類縁体の探索と構造活性相関

    ○神崎 浩, 臼木博一,仁戸田照彦,畑中 唯史

    日本農薬学会第36回大会  日本農薬学会

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    Event date: 2011.3.16 - 2011.3.18

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:玉川大学(震災のため開催されなかったが,要旨発行をもって発表は成立との主催者通達)  

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  • 糸状菌由来β-N-acetylglucosaminidase阻害物質pochonicineの類縁体の探索と培養生産性向上の検討

    ○仁戸田照彦, 山田あさ美,豊岡実穂,臼木博一,奥田 徹,神崎 浩

    日本農薬学会第36回大会  日本農薬学会

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    Event date: 2011.3.16 - 2011.3.18

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:玉川大学(震災のため開催されなかったが,要旨発行をもって発表は成立との主催者通達)  

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  • 膜面液体培養による生理活性環状ジペプチド類の生産

    ○今宮亮,仁戸田照彦,神崎浩

    2010年度 日本農芸化学会中四国支部 第29回講演会  日本農芸化学会中四国支部

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    Event date: 2011.1.22

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:徳島大学薬学部  

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  • β-N-Acetylglucosaminidase阻害物質pochonicineとその類縁体の培養生産

    ○山田あさ美,豊岡実穂,臼木博一,奥田徹,神崎浩,仁戸田照彦

    2010年度 日本農芸化学会中四国支部 第29回講演会  日本農芸化学会中四国支部

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    Event date: 2011.1.22

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:徳島大学薬学部  

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  • Inhibitory properties of β-N-acetylglucosaminidase inhibitor TMG -chitotriomycin and structurally related compounds produced by Streptomyces anulatus International conference

    Pacifichem 2010 

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    Event date: 2010.12.15 - 2010.12.21

    Language:English   Presentation type:Poster presentation  

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  • β-N-acetylglucosaminidase inhibitor pochonicine and its analogs produced by the fungal strain Pochonia suchlasporia var. suchlasporia TAMA 87 International conference

    Pacifichem 2010 

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    Event date: 2010.12.15 - 2010.12.21

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  • Production of modified dehydro cyclic dipeptides International conference

    Pacifichem 2010 

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    Event date: 2010.12.15 - 2010.12.21

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  • Enzyme from Aspergillus niger catalyzing transglucosylation of cellobiose to 6-hydroxy group of L-ascorbic acid International conference

    Pacifichem 2010 

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    Event date: 2010.12.15 - 2010.12.21

    Language:English   Presentation type:Poster presentation  

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  • 微生物由来の新規キチン分解系酵素阻害剤の性質と応用検討

    仁戸田 照彦,神崎 浩,山田 あさ美 (M2),塩田 博人 (M1)

    岡山大学知恵の見本市2010 

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    Event date: 2010.11.5

    Presentation type:Poster presentation  

    Venue:岡山市  

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  • アスコルビン酸の6位水酸基を特異的にβ-グルコシル化するAspergillus niger由来酵素 (第2報)?糖転移活性の詳細検討?

    ○早川有美,仁戸田照彦,神崎浩

    2010年度 日本農芸化学会中四国支部大会(第28回講演会)  日本農芸化学会中四国支部

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    Event date: 2010.9.24 - 2010.9.25

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:高松市  

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  • An enzyme from Aspergillus niger catalyzing transglucosylation of ascorbic acid to produce 6-O-(β-D-glucopyranosyl)ascorbic acid (2nd Report)

    Yumi Hayakawa, Teruhiko Nitoda, and Hiroshi Kanzaki*

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    Event date: 2010.9.23 - 2010.9.24

    Language:Japanese   Presentation type:Poster presentation  

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  • Production of chitinase inhibitors by Streptomyces anulatus, a β-N-acetylglucosaminidase inhibitor-producing actinomycete

    Hiroto Shiota, Misato Ichikawa, Hirokazu Usuki, Hiroshi Kanzaki, Teruhiko Nitoda*

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    Event date: 2010.9.23 - 2010.9.24

    Language:Japanese   Presentation type:Poster presentation  

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  • 糸状菌が植物成分を材料に生産する新たな生理活性物質:グリコシダーゼ阻害剤 pochonicineの例 Invited

    仁戸田照彦

    おかやまバイオアクティブ研究会 第37回シンポジウム  おかやまバイオアクティブ研究会

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    Event date: 2010.6.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山市(岡山理科大学)  

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  • 酵素変換法により見出した糸状菌由来環状ジペプチド類

    ○福田 優、仁戸田 照彦、神崎 浩

    日本農芸化学会2010年度大会  日本農芸化学会

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    Event date: 2010.3.27 - 2010.3.30

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京  

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  • Search for chitinolytic enzyme inhibitors of microbial origin International conference

    Symposium on commemoration of international exchange agreement between School of Chemistry and Materials Science, Shaanxi Normal University and Graduate School of Natural Science and Technology, Oka 

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    Event date: 2009.12.17 - 2009.12.18

    Language:English   Presentation type:Oral presentation (invited, special)  

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  • オリーブ葉内在性酵素によるオレウロペインの効率的脱グルコシル化

    ○秋久恵里佳,吉田靖弘1,徐恵美1,*仁戸田照彦,神崎浩

    2009年度日本農芸化学会関西・中四国・西日本支部、日本栄養・食糧学会九州・沖縄支部および日本食品科学工学会西日本支部合同大会 

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    Event date: 2009.10.30 - 2009.10.31

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:沖縄県中頭郡西原町(琉球大学)  

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  • アスコルビン酸6位水酸基を特異的にb-グルコシル化するAspergillus niger 由来酵素

    ○早川有美,水津佳子,*仁戸田照彦,神崎浩

    2009年度日本農芸化学会関西・中四国・西日本支部、日本栄養・食糧学会九州・沖縄支部および日本食品科学工学会西日本支部合同大会 

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    Event date: 2009.10.30 - 2009.10.31

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:沖縄県中頭郡西原町(琉球大学)  

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  • Streptomyces albulus KO23株由来組換えcyclo (Leu-Phe) oxidaseの精製と諸性質

    ○今村六美,畑中唯史1,臼木博一1,稲垣賢二,田村隆,*仁戸田照彦,神崎浩

    2009年度日本農芸化学会関西・中四国・西日本支部、日本栄養・食糧学会九州・沖縄支部および日本食品科学工学会西日本支部合同大会 

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    Event date: 2009.10.30 - 2009.10.31

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:沖縄県中頭郡西原町(琉球大学)  

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  • Novel polyhydroxylated pyrrolizidine alkaloid from a fungal strain grown on a plant-based solid medium and its potent beta-N-acetylglucosaminidase inhibitory activity International conference

    Hirokazu Usuki, Miho Toyo-oka, Asami Yamada, *Teruhiko Nitoda, Hiroshi Kanzaki, Toru Okuda

    日本学術振興会アジア研究教育拠点事業「東アジア植物遺伝資源シンポジウム」 

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    Event date: 2009.10.6 - 2009.10.7

    Language:English   Presentation type:Poster presentation  

    Venue:岡山市  

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  • 糸状菌4菌株におけるβ-N-acetylglucosaminidase阻害物質生産培養条件の検討

    山田あさ美,千原理恵,神崎 浩,奥田 徹,*仁戸田照彦

    日本農芸化学会中四国支部 第24回講演会 

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    Event date: 2009.5.23

    Language:English   Presentation type:Oral presentation (general)  

    Venue:松江市  

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  • 糸状菌由来環状ジペプチド類の酵素変換法による探索

    福田 優、ARUNRATTIYAKORN Panarat、平田 里枝、*仁戸田 照彦、神崎 浩

    日本農芸化学会2009年度大会 

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    Event date: 2009.3.27 - 2009.3.29

    Presentation type:Poster presentation  

    Venue:福岡市  

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  • Streptomyces albulus KO23株由来cyclo(Leu-Phe) oxidaseとその異種発現組換え酵素との性質比較

    今村 六美、長尾 真智子、畑中 唯史1、臼木 博一1、稲垣 賢二、田村 隆、*仁戸田 照彦、神崎 浩

    日本農芸化学会2009年度大会 

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    Event date: 2009.3.27 - 2009.3.29

    Presentation type:Poster presentation  

    Venue:福岡市  

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  • β-N-アセチルグルコサミニダーゼ阻害剤 MT-1 の合成

    佐藤 瑞穂、豊岡 実穂、臼木 博一、*仁戸田 照彦、神崎 浩、中島 修平、馬場 直道、泉 実

    日本農芸化学会2009年度大会 

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    Event date: 2009.3.27 - 2009.3.29

    Presentation type:Poster presentation  

    Venue:福岡市  

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  • 2-O-(β-D-glucopyranosyl)ascorbic acid 合成に利用可能な担子菌由来酵素の探索

    田中 和哉、寺田 茉衣子1、時本 景亮2、*仁戸田 照彦、神崎 浩

    日本農芸化学会2009年度大会 

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    Event date: 2009.3.27 - 2009.3.29

    Presentation type:Poster presentation  

    Venue:福岡市  

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  • 微生物由来キチン分解系酵素阻害剤の探索と応用

    *仁戸田照彦

    岡山大学知恵の見本市2008 

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    Event date: 2008.11.7

    Presentation type:Poster presentation  

    Venue:岡山市  

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  • 昆虫β-N-アセチルグルコサミニダーゼ特異的阻害剤生産放線菌によるキチナーゼ阻害剤の生産

    ○市川美里,*仁戸田照彦,神崎 浩

    2008 年度 日本農芸化学会・中四国支部大会 

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    Event date: 2008.9.13

    Presentation type:Oral presentation (general)  

    Venue:鳥取市  

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  • 生理活性を示すイソプレニル化環状ジペプチド類のMS/MS分析

    ○原田幸枝1,臼木博一2,畑中唯史2,*仁戸田照彦1,神崎 浩1

    2008 年度 日本農芸化学会・中四国支部大会 

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    Event date: 2008.9.13

    Presentation type:Oral presentation (general)  

    Venue:鳥取市  

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  • 2-O-(β-D-glucopyranosyl)ascorbic acid の酵素合成に利用可能な担子菌由来酵素の探索

    田中 和哉、寺田 茉衣子、時本景亮、神崎 浩、*仁戸田 照彦

    日本農芸化学会2008年度大会 

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    Event date: 2008.3.26 - 2008.3.29

    Venue:名古屋市  

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  • アスコルビン酸を位置選択的にβ-グルコシル化する糸状菌由来酵素

    水津佳子,寺田芽衣子,田中和哉,*仁戸田照彦,神崎浩

    日本農芸化学会中四国支部第20回講演会(例会) 

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    Event date: 2008.1.26

    Venue:徳島市  

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  • 昆虫β-N-acetyl-D-glucosaminidase特異的阻害剤HU-1構成異常糖の合成と阻害活性評価 (Synthesis of N,N,N-trimethylglucosaminium, a characteristic sugar component of the insect β-N-acetyl-D-glucosaminidase specific inhibitor HU-1, and evaluation of its enzyme inhibitory activity)

    市川美里,臼木博一,*仁戸田照彦,神崎 浩

    第11回生体触媒化学シンポジウム 

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    Event date: 2008.1.24 - 2008.1.25

    Venue:鳥取市  

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  • 糸状菌Pochonia suchlasporiaが生産する新規β-N-acetylglucosaminidase阻害剤 (Isolation of a novel β-N-acetylglucosaminidase inhibitor produced by the fungal strain Pochonia suchlasporia, and evaluation of its enzyme inhibitory activity)

    豊岡実穂,臼木博一,*仁戸田照彦,神崎 浩,奥田 徹

    第11回生体触媒化学シンポジウム 

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    Event date: 2008.1.24 - 2008.1.25

    Presentation type:Poster presentation  

    Venue:鳥取市  

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  • 微生物が生産するキチン分解系酵素阻害剤の探索

    *仁戸田 照彦

    第10回バイオプロセスによる有機合成:岡山ミニシンポジウム 

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    Event date: 2008.1.22

    Presentation type:Oral presentation (general)  

    Venue:岡山市  

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  • Pochonia suchlasporiaの生産する新規N-アセチル・グルコサミニダーゼ阻害剤

    *仁戸田照彦・神崎浩

    第16回微生物資源ワークショップ 医農薬探索の初期リード化合物の最近 (Novel natural product leads under early development) 

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    Event date: 2007.10.26 - 2007.10.27

    Presentation type:Oral presentation (general)  

    Venue:富士吉田市  

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  • Purification and Characterization of a Biosurfactant Produced by Issatchenkia orientalis SR4

    Wichuda Katemai, Suppasil Maneerat, Fusako Kawai, *Teruhiko Nitoda, Hiroshi Kanzaki, and Aran H-Kittikun

    JSPS-NRCT Concluding Joint Seminar on Development of Thermotolerant Microbial Resources and Their Applications (JSPS-NRCT拠点大学方式交流事業(微生物の生物化学的研究)最終合同セミナー) 

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    Event date: 2007.10.18 - 2007.10.20

    Presentation type:Oral presentation (general)  

    Venue:Nakhon Si Thammarat(タイ国)  

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  • Cyclic dipeptides: development of detection method and enzymatic preparation of their dehydro derivatives International conference

    Panarat Arunrattiyakorn, *Teruhiko Nitoda, and Hiroshi Kanzaki

    JSPS-NRCT Concluding Joint Seminar on Development of Thermotolerant Microbial Resources and Their Applications (JSPS-NRCT拠点大学方式交流事業(微生物の生物化学的研究)最終合同セミナー) 

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    Event date: 2007.10.18 - 2007.10.20

    Presentation type:Oral presentation (general)  

    Venue:Nakhon Si Thammarat(タイ国)  

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  • Biosurfactants produced by microorganisms in Thailand International conference

    B. Thanomsub, P. Arunrattiyakorn, T. Watcharachaipong, K. Chotelersak, W. Pumeechockchai, A. Limtrakul, W. Petchleelaha, *T. Nitoda, H. Kanzaki

    JSPS-NRCT Concluding Joint Seminar on Development of Thermotolerant Microbial Resources and Their Applications (JSPS-NRCT拠点大学方式交流事業(微生物の生物化学的研究)最終合同セミナー) 

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    Event date: 2007.10.18 - 2007.10.20

    Presentation type:Oral presentation (general)  

    Venue:Nakhon Si Thammarat(タイ国)  

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  • 昆虫β- N-acetylglucosaminidase 特異的阻害剤HU-1の構成異常糖の合成と阻害活性評価

    *仁戸田照彦,○市川美里,臼木博一,神崎浩

    2007年度 日本農芸化学会中四国・西日本支部合同大会 

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    Event date: 2007.9.14 - 2007.9.15

    Presentation type:Oral presentation (general)  

    Venue:山口市  

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  • Pochonia 属糸状菌が生産する新規β- N-acetylglucosaminidase 阻害剤の阻害活性評価

    *仁戸田照彦,○豊岡実穂,臼木博一,土屋有紀,奥田徹,神崎浩

    2007年度 日本農芸化学会中四国・西日本支部合同大会 

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    Event date: 2007.9.14 - 2007.9.15

    Presentation type:Oral presentation (general)  

    Venue:山口市  

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  • 糸状菌由来の新規b-N-acetylglucosaminidase阻害剤

    *仁戸田照彦,豊岡実穂,臼木博一,奥田 徹,神崎 浩

    日本農薬学会第32回大会 

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    Event date: 2007.4.4

    Presentation type:Oral presentation (general)  

    Venue:東京都小金井市  

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  • 強力な抗腫瘍活性物質へ変換可能なphenylahistinアナログ,aurantiamineの微生物生産と酵素変換

    神崎 浩、平田 里枝、*仁戸田 照彦

    日本農芸化学会2007年度大会 

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    Event date: 2007.3.25

    Presentation type:Oral presentation (general)  

    Venue:東京都世田谷区  

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  • Verticillium sp. F40株が生産する新規β-N-acetylglucosaminidase阻害剤

    *仁戸田照彦,豊岡実穂,臼木博一,神崎浩,奥田徹

    日本農芸化学会2007年度大会 

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    Event date: 2007.3.24 - 2007.3.27

    Presentation type:Oral presentation (general)  

    Venue:東京都世田谷区  

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  • 昆虫キチン代謝を特異的に阻害する微生物代謝産物

    *仁戸田照彦

    第3回産学官連携新産業創出研究会 「新規培養法を用いた糸状菌由来のスーパー酵素群の発現と革新的機能の探索・応用」 

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    Event date: 2006.12.18

    Venue:岡山市  

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  • 大腸菌で発現させた放線菌由来Cyclo(Leu-Phe) oxidase の精製と性質検討

    ○長尾真智子,平田里枝,*仁戸田照彦,神崎浩

    第10回生体触媒化学シンポジウム 

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    Event date: 2006.12.14 - 2006.12.15

    Venue:北九州市  

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  • A search for inhibitors against insect chitinolytic enzymes

    *Teruhiko Nitoda

    A seminar in Faculty of Science, Srinakharinwirot University 

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    Event date: 2006.11.17

    Venue:バンコク(タイ)  

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  • A search for selective inhibitors against insect ァ-N-acetylglucosaminidase

    Hirokazu Usuki1), *Teruhiko Nitoda1), Nahoko Yamaji 2), Takashi Iwashita2), Hajime Komura2), and Hiroshi Kanzaki1)

    The 5th JSPS-NRCT Joint Seminar on Development of Thermotolerant Microbial Resources and Their Applications, 

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    Event date: 2006.11.7 - 2006.11.10

    Venue:Pattaya (タイ)  

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  • HU-1, a novel enzyme inhibitor specific for β-N-acetylglucosaminidases of insect and fungal origin, produced by Streptomyces anulatus NBRC13369

    H. Usuki, *T. Nitoda, N. Yamaji, T. Iwashita, H. Komura, H. Kanzaki

    第11回 IUPAC農薬化学国際会議 (11th IUPAC International Congress of Pesticide Chemistry) 

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    Event date: 2006.8.6 - 2006.8.11

    Venue:神戸市  

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  • ISOLATION AND STRUCTURE ELUCIDATION OF A NOVEL ENZYME INHIBITOR SPECIFIC FOR BETA-N-ACETYLGLUCOSAMINIDASES OF INSECT & FUNGAL ORIGIN

    Hirokazu Usuki, *Teruhiko Nitoda, Nahoko Yamaji, Takashi Iwashita, Hajime Komura, and Hiroshi Kanzaki

    第25回天然物化学国際会議・第5回生物多様性国際会議 (ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products) 

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    Event date: 2006.7.23 - 2006.7.28

    Venue:京都市  

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  • Homocysteine thiolactone加水分解酵素を有する微生物: 探索とその立体選択性

    神崎 浩、○本田 彰三、*仁戸田 照彦

    日本農芸化学会2006年度大会 

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    Event date: 2006.3.26 - 2006.3.28

    Venue:京都市  

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  • 環状ジペプチドから両側鎖脱水素型環状ジペプチドへの酵素変換における変換率向上の試み

    神崎 浩、○平田 里枝、朝 魯門、*仁戸田 照彦

    日本農芸化学会2006年度大会 

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    Event date: 2006.3.26 - 2006.3.28

    Venue:京都市  

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  • 新規b-N-acetylglucosaminidase阻害剤HU-1の阻害特異性

    臼木博一,○*仁戸田照彦,神崎 浩

    日本農薬学会第31回大会 

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    Event date: 2006.3.21 - 2006.3.23

    Venue:福岡市  

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  • 新規β-N-acetylglucosaminidase阻害剤HU-1の構造解析

    ○臼木博一,*仁戸田照彦,山路奈保子*,岩下 孝*,小村 啓*,神崎 浩

    日本農薬学会第31回大会 

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    Event date: 2006.3.21 - 2006.3.23

    Venue:福岡市  

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  • Enzymatic synthesis of bioactive dehydrogenated cyclic dipeptides by cyclo(Leu-Phe) oxidase from Streptomyces albulus KO23.

    R. Hirata; H. Kanzaki; B. Ikeda; S. Yanagisawa; *T. Nitoda

    2005 環太平洋国際化学会議 (PACIFICHEM 2005) 

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    Event date: 2005.12.15 - 2005.12.20

    Venue:ハワイ ホノルル  

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  • Screening for cyclic dipeptide producing microorganisms by cyclo(Leu-Phe) oxidase.

    P. Arunrattiyakorn, *T. Nitoda, H. Kanzaki

    2005 環太平洋国際化学会議 (PACIFICHEM 2005) 

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    Event date: 2005.12.15 - 2005.12.20

    Venue:ハワイ ホノルル  

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  • Search for enzyme inhibitors specific for insect b-N-acetylglucosaminidase

    H. Usuki, T. *Nitoda, H. Kanzaki

    2005 環太平洋国際化学会議 (PACIFICHEM 2005) 

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    Event date: 2005.12.15 - 2005.12.20

    Venue:ハワイ ホノルル  

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  • Production of a cell cycle inhibitor phenylahistin using membrane-surface liquid culture.

    T. Sugihara; H. Kanzaki; T. Fukuda; *T. Nitoda

    2005 環太平洋国際化学会議 (PACIFICHEM 2005) 

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    Event date: 2005.12.15 - 2005.12.20

    Venue:ハワイ ホノルル  

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  • Purification and characterization of L-homocysteine thiolactone hydrolase involved in dynamic resolution process of L-homocysteine.

    S. Honda, H. Kanzaki, S. Yougai, H. Fujita, *T. Nitoda

    2005 環太平洋国際化学会議 (PACIFICHEM 2005) 

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    Event date: 2005.12.15 - 2005.12.20

    Venue:ハワイ ホノルル  

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  • Purification and charactarization of cyclo(Leu-Phe) oxidase from Streptomyces albulus KO23: An enzyme useful for bioactive dehydro cyclic dipeptide production.

    M. Nagao; H. Kanzaki; A. Morimoto; C. Takeda; *T. Nitoda

    2005 環太平洋国際化学会議 (PACIFICHEM 2005) 

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    Event date: 2005.12.15 - 2005.12.20

    Venue:ハワイ ホノルル  

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  • Production of 2-O-(b-D-glucopylanosyl)ascorbic acid by cultured cells of Lycium chinese.

    T. Fujitani; H. Kanzaki; Y. Yamachika; T. Nitoda

    2005 環太平洋国際化学会議 (PACIFICHEM 2005) 

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    Event date: 2005.12.15 - 2005.12.20

    Venue:ハワイ ホノルル  

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  • Cyclo(Leu-Phe)酸化酵素が触媒するcyclo(Asp(OMe)-Asp(OMe))の脱水素反応

    神崎浩,○平田里枝,柳澤恵広,*仁戸田照彦

    2005年度 日本農芸化学会 関西・中四国・西日本支部合同大会 

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    Event date: 2005.9.30 - 2005.10.1

    Venue:吹田市  

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  • 昆虫のβ-N-acetylglucosaminidaseに特異的な阻害剤の探索(第3報)

    ○臼木 博一、*仁戸田 照彦、亀山 貴正、神崎 浩

    日本農芸化学会2005年度大会 

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    Event date: 2005.3.28 - 2005.3.30

    Venue:札幌市  

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  • 放線菌由来環状ジペプチド酸化酵素を利用するCyclo(His-His)脱水素体の合成

    神崎 浩、○平田 里枝、武田 周大、*仁戸田 照彦

    日本農芸化学会2005年度大会 

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    Event date: 2005.3.28 - 2005.3.30

    Venue:札幌市  

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  • Screening for cyclic dipeptide-producing microorganisms by cyclo(Leu-Phe) oxidase

    ○Arunrattiyakorn Panarat、*仁戸田 照彦、神崎 浩

    日本農芸化学会2005年度大会 

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    Event date: 2005.3.28 - 2005.3.30

    Venue:札幌市  

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  • 糸状菌TNPT116-Cz株が生産する昆虫キチナーゼ阻害多糖FPS-1の阻害特性

    ○亀山貴正,臼木博一,*仁戸田照彦,神崎 浩

    第8回生体触媒化学シンポジウム 

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    Event date: 2004.12.16 - 2004.12.17

    Venue:横浜市  

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  • Agrobacterium radiobacter 由来L-Homocysteine thiolactone 加水分解酵素の精製と性状解析

    ○本田彰三,用貝さと子,藤田恒,仁戸田照彦,*神崎浩

    第8回生体触媒化学シンポジウム 

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    Event date: 2004.12.16 - 2004.12.17

    Venue:横浜市  

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  • L-Homocysteine thiolactone 加水分解酵素の精製と諸性質の検討(第2報)

    神崎浩、○本田彰三、用貝さと子、*仁戸田照彦

    日本農芸化学会・2004年度中四国支部大会 

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    Event date: 2004.9.17 - 2004.9.18

    Venue:徳島市  

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  • 昆虫のb-N-acetylglucosaminidaseに特異的な酵素阻害剤の探索(第2報)

    ○臼木博一、*仁戸田照彦、亀山貴正、神崎浩

    日本農芸化学会・2004年度中四国支部大会 

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    Event date: 2004.9.17 - 2004.9.18

    Venue:徳島市  

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  • 糸状菌TNPT116-Cz株が生産する昆虫キチナーゼ阻害多糖FPS-1の阻害特性(第2報)

    *仁戸田 照彦、○亀山 貴正、臼木 博一、神崎 浩

    日本農芸化学会・2004年度中四国支部大会 

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    Event date: 2004.9.17 - 2004.9.18

    Venue:徳島市  

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  • 膜面液体培養法による細胞周期阻害剤phenylahistinの生産

    神崎浩,○杉原孝治,福田隆雄,*仁戸田照彦

    日本農芸化学会・2004年度中四国支部大会 

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    Event date: 2004.9.17 - 2004.9.18

    Venue:徳島市  

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  • Albonoursin生合成系の素反応 cyclo (Leu-ΔPhe) からalbonoursinへの変換を触媒する酵素に関する検討

    神崎 浩、○武田 周大、森本 篤史、*仁戸田 照彦

    日本農芸化学会・2004年度大会 

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    Event date: 2004.3.28 - 2004.3.31

    Venue:広島  

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  • 昆虫のβ-N-acetylglucosaminidaseに特異的な阻害剤の探索

    ○臼木 博一、*仁戸田 照彦、亀山 貴正、神崎 浩

    日本農芸化学会・2004年度大会 

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    Event date: 2004.3.28 - 2004.3.31

    Venue:広島  

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  • 糸状菌TNPT116-Cz株が生産する昆虫キチナーゼ阻害多糖FPS-1の阻害特性

    *仁戸田 照彦、○亀山 貴正、臼木 博一、神崎 浩

    日本農芸化学会・2004年度大会 

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    Event date: 2004.3.28 - 2004.3.31

    Venue:広島  

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  • Cyclo (Gly-Leu)資化性菌が生産するaminopeptidase

    神崎 浩、○則武 寛通、*仁戸田 照彦

    日本農芸化学会・2004年度大会 

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    Event date: 2004.3.28 - 2004.3.31

    Venue:広島  

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  • Characterization of cyclo (Leu-Phe) dehydrogenase from an actinomycete Streptomyces albulus KO23(放線菌由来cyclo (Leu-Phe)脱水素酵素の性状解析)

    森本 篤史・武田 周大・池田 万里・*仁戸田 照彦・神崎 浩

    第7回生体触媒化学シンポジウム 

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    Event date: 2003.12.11 - 2003.12.12

    Venue:札幌市  

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  • Fungal chitinases coproduced with insect chitinase inhibitors (糸状菌が昆虫キチナーゼ阻害物質とともに生産するキチナーゼ)

    亀山 貴正・臼木 博一・*仁戸田 照彦・神崎 浩

    第7回生体触媒化学シンポジウム 

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    Event date: 2003.12.11 - 2003.12.12

    Venue:札幌市  

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  • 放線菌由来cyclo (Leu-Phe)脱水素酵素の性状解析

    神崎 浩、 ○森本篤史、 池田万里、 *仁戸田照彦

    日本農芸化学会西日本支部,同中四国支部,日本栄養・食糧学会西日本支部,日本食品科学工学会西日本支部合同大会 

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    Event date: 2003.9.19 - 2003.9.20

    Venue:鹿児島市  

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  • Cyclo(Leu-Phe)からalbonoursinへの酵素変換反応の解析

    神崎 浩、 ○武田周大、 森本篤史、 *仁戸田照彦

    日本農芸化学会西日本支部,同中四国支部,日本栄養・食糧学会西日本支部,日本食品科学工学会西日本支部合同大会 

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    Event date: 2003.9.19 - 2003.9.20

    Venue:鹿児島市  

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  • 昆虫キチナーゼ阻害物質生産糸状菌由来のキチナーゼ

    *仁戸田照彦、亀山貴正、臼木博一、神崎 浩

    日本農芸化学会西日本支部,同中四国支部,日本栄養・食糧学会西日本支部,日本食品科学工学会西日本支部合同大会 

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    Event date: 2003.9.19 - 2003.9.20

    Venue:鹿児島市  

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  • Marine biosurfactant : Purification and characterization of a biosurfactant produced by Myroides odoratus SMT1 isolated from seawater in Thailand

    ○Suppasil Maneerat, Akio Tani, Aran H-Kittikun1, *Teruhiko Nitoda, Hiroshi Kanzaki, Fusako Kawai

    日本農芸化学会 2003年度大会 

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    Event date: 2003.4.2

    Venue:神奈川県藤沢市  

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  • 糸状菌が生産する細胞分裂阻害物質 phenylahistin の生合成

    神崎 浩、福田 隆雄、池田 万里、森本 篤史、*仁戸田 照彦

    日本農芸化学会 2003年度大会 

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    Event date: 2003.4.2

    Venue:神奈川県藤沢市  

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  • L-Homocysteine thiolactone加水分解酵素の精製と諸性質の検討

    神崎 浩、○用貝 さと子、*仁戸田 照彦

    日本農芸化学会2003年度大会 

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    Event date: 2003.4.1 - 2003.4.3

    Venue:藤沢市  

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  • 糸状菌が生産する細胞分裂阻害物質 phenylahistin の生合成

    神崎 浩、○福田 隆雄、池田 万里、森本 篤史、*仁戸田 照彦

    日本農芸化学会2003年度大会 

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    Event date: 2003.4.1 - 2003.4.3

    Venue:藤沢市  

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  • L-Homocysteine thiolactone加水分解酵素の精製と諸性質の検討

    神崎 浩、用貝 さと子、*仁戸田 照彦

    日本農芸化学会 2003年度大会 

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    Event date: 2003.4.1

    Venue:神奈川県藤沢市  

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  • 放線菌由来環状ジペプチド脱水素酵素系を利用する cyclo(Phe-Pro) 脱水素体 の合成

    神崎 浩,池田万里,森本篤史,*仁戸田照彦

    日本農芸化学会 2002年度 中四国支部大会 

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    Event date: 2002.9.20

    Venue:島根県松江市  

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  • 放線菌由来 cyclo(Leu-Phe) 脱水素酵素の精製と諸性質の検討

    神崎 浩,森本篤史,池田万里,*仁戸田照彦

    日本農芸化学会 2002年度 中四国支部大会 

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    Event date: 2002.9.20

    Venue:島根県松江市  

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  • Agrobacterium 属細菌の凝集促進活性を有する微生物細胞外多糖の性状解析

    神崎 浩,新納 愛,*仁戸田照彦

    日本農芸化学会 2002年度 中四国支部大会 

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    Event date: 2002.9.20

    Venue:島根県松江市  

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  • DL-Homocysteine thiolactone から L-homocysteine への微生物変換(第三報)

    神崎浩,用貝さと子,藤田恒,*仁戸田照彦

    日本農芸化学会 2002年度大会 

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    Event date: 2002.3.25 - 2002.3.27

    Venue:仙台市  

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  • 糸状菌TNPT116-Cz株が生産する昆虫キチナーゼ阻害活性を有する多糖

    *仁戸田照彦,臼木博一,神崎浩

    日本農芸化学会 2002年度大会 

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    Event date: 2002.3.25 - 2002.3.27

    Venue:仙台市  

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  • 糸状菌HUF45株が生産する昆虫キチナーゼ阻害物質

    *仁戸田照彦,臼木博一,神崎浩

    日本農芸化学会 2002年度大会 

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    Event date: 2002.3.25 - 2002.3.27

    Venue:仙台市  

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  • 強力な細胞分裂阻害活性を有する dehydrophenylahistin の化学ー酵素合成

    神崎浩,池田万里,福田隆雄,森本篤史,*仁戸田照彦

    日本農芸化学会 2002年度大会 

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    Event date: 2002.3.25 - 2002.3.27

    Venue:仙台市  

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  • 糸状菌の生産する細胞分裂阻害物質 (-)-Phenylahistin の培養生産

    神崎浩,福田隆雄,*仁戸田照彦

    本農芸化学会 2002年度大会 

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    Event date: 2002.3.25 - 2002.3.27

    Venue:仙台市  

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  • Cyclo(Gly-Leu)資化性菌由来Leucylglycine 分解酵素

    三吉和之、*仁戸田照彦、神崎 浩

    第5回生体触媒化学シンポジウム 

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    Event date: 2001.12.13 - 2001.12.14

    Venue:岡山市  

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  • 糸状菌由来昆虫キチナーゼ阻害物質の探索

    *仁戸田照彦,臼木博一,神崎浩

    第5回生体触媒化学シンポジウム 

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    Event date: 2001.12.13 - 2001.12.14

    Venue:岡山市  

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  • 生理活性を示す脱水素環状ジペプチド生産に有用な放線菌由来の新規脱水素酵素系

    森本篤史、池田万里、*仁戸田照彦、神崎 浩

    第5回生体触媒化学シンポジウム 

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    Event date: 2001.12.13 - 2001.12.14

    Venue:岡山市  

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  • Agrobacterium tumefaciens の植物形質転換に関与する多糖

    臼杵理恵,*仁戸田照彦,神崎浩

    日本農芸化学会 2001年度 関西・西日本・中四国支部合同大会 

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    Event date: 2001.10.13

    Venue:岡山市  

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  • 糸状菌由来昆虫キチナーゼ阻害物質の探索および性状比較

    *仁戸田照彦,臼木博一,倉田淳志,神崎浩

    日本農芸化学会 2001年度 関西・西日本・中四国支部合同大会 

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    Event date: 2001.10.13

    Venue:岡山市  

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  • 放線菌由来環状ジペプチド脱水素酵素系を利用するCyclo(Met-Met) 脱水素体の合成

    神崎浩,池田万里,柳澤恵広,森本篤史,*仁戸田照彦

    日本農芸化学会 2001年度 関西・西日本・中四国支部合同大会 

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    Event date: 2001.10.13

    Venue:岡山市  

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  • Cyclo(Leu-Phe)から albonoursin への脱水素反応を触媒する新規酵素系(第五報)

    赤澤和美,柳澤恵広,*仁戸田照彦,神崎浩

    日本農芸化学会 2001年度大会 

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    Event date: 2001.3.24 - 2001.3.26

    Venue:京都  

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  • 放線菌由来の新規環状ジペプチド脱水素酵素系を利用する有用物質生産(第二報)

    柳澤恵広,赤澤和美,*仁戸田照彦,神崎浩

    日本農芸化学会 2001年度大会 

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    Event date: 2001.3.24 - 2001.3.26

    Venue:京都  

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  • 糸状菌の生産する昆虫キチナーゼ阻害物質

    *仁戸田照彦,臼木博一,倉田淳志,車谷治樹,神崎浩

    日本農芸化学会 2001年度大会 

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    Event date: 2001.3.24 - 2001.3.26

    Venue:京都  

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  • A Search for insect chitinase inhibitors of fungal origin

    *Teruhiko Nitoda, Atsushi Kurata, Haruki Kurumatani, Hiroshi Kanzaki

    日本化学会,アメリカ化学会,カナダ化学会,オーストラリア化学会,ニュージーランド化学会 主催・ 2000 環太平洋国際化学会議 

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    Event date: 2000.12.14 - 2000.12.19

    Venue:米国ハワイ州,ホノルル市  

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  • Production of Novel Bioactive Dehydro Cyclic Dipeptides by Streptomyces Enzyme System

    Hiroshi Kanzaki, Satohiro Yanagisawa, Kazumi Akazawa & *Teruhiko Nitoda

    日本化学会,アメリカ化学会,カナダ化学会,オーストラリア化学会,ニュージーランド化学会 主催・ 2000 環太平洋国際化学会議 

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    Event date: 2000.12.14 - 2000.12.19

    Venue:米国ハワイ州,ホノルル市  

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  • 糸状菌の生産する昆虫キチナーゼ阻害物質

    *仁戸田照彦,倉田淳志,車谷治樹,神崎浩

    日本農芸化学会 2000年度大会 

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    Event date: 2000.4.1 - 2000.4.2

    Venue:東京  

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  • 放線菌の新規酵素系を用いた細胞分裂阻害活性を示す脱水素型環状ジペプチド類の合成

    神崎浩,柳澤恵広,赤澤和美,仁戸田照彦

    日本農芸化学会 2000年度大会 

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    Event date: 2000.4.1 - 2000.4.2

    Venue:東京  

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  • Cyclo(Gly-Leu)資化性菌が生成するdipeptidase

    神崎浩,三吉和之,水田直樹,*仁戸田照彦

    日本農芸化学会 2000年度大会 

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    Event date: 2000.4.1 - 2000.4.2

    Venue:東京  

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  • Agrobacterium 属細菌の植物への付着を阻害するoxazolomycin diacetate の作用点

    神崎浩,鶴本智大,*仁戸田照彦

    日本農芸化学会 2000年度大会 

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    Event date: 2000.4.1 - 2000.4.2

    Venue:東京  

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  • Cyclo(Leu-Phe)からalbonourcinへの脱水素反応を触媒する新規酵素系(第三報)

    神崎浩,赤澤和美,柳澤恵広,*仁戸田照彦

    日本農芸化学会 平成11年度 中部支部・関西支部合同大会 

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    Event date: 1999.10.1 - 1999.10.2

    Venue:岐阜市  

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  • 放線菌の酵素による環状ジペプチド類から脱水素型環状ジペプチド類への微生物変換

    神崎浩,柳澤恵広,赤澤和美,*仁戸田照彦

    日本農芸化学会 平成11年度 中部支部・関西支部合同大会 

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    Event date: 1999.10.1 - 1999.10.2

    Venue:岐阜市  

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  • インドネシア産植物に含まれる殺線虫性物質(その2)

    中島修平,○アレン・ヨハネス,*仁戸田照彦,神崎浩,馬場直道,河津一儀

    日本農芸化学会 平成11年度 中部支部・関西支部合同大会 

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    Event date: 1999.10.1 - 1999.10.2

    Venue:岐阜市  

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  • DL-Homocysteine thiolactone からL-homocysteineへの微生物変換(第二報)

    神崎 浩,○藤田 恒,*仁戸田照彦

    日本農芸化学会1999年度大会 

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    Event date: 1999.3.30 - 1999.4.1

    Venue:福岡市  

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  • Oxazolomycin ester の示す Agrobacterium 属細菌の植物への付着阻害活性

    神崎 浩,○鶴本智大,*仁戸田照彦,河律一儀,Ann G. Matthysse

    日本農芸化学会1999年度大会 

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    Event date: 1999.3.30 - 1999.4.1

    Venue:福岡市  

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  • Cyclo(Phe-Leu)からalbonoursinへの脱水素反応を触媒する新規酵素系(第二報)

    神崎 浩,○赤澤和美,柳澤恵広,*仁戸田照彦

    日本農芸化学会1999年度大会 

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    Event date: 1999.3.30 - 1999.4.1

    Venue:福岡市  

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Industrial property rights

  • ワインパミス麹及びその製造方法

    神崎 浩, 仁戸田照彦, 平野幸司, 樋口松之助

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    Applicant:国立大学法人 岡山大学

    Application no:特願2022-033920  Date applied:2022.3.4

    Announcement no:特開2023-129118  Date announced:2023.9.14

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  • ノラチリオールの新規な製造方法とその用途

    川上 秀昭, 奥田 洋, 桑原 浩誠, 西谷 洋輔, 神崎 浩, 仁戸田 照彦, ハサナ ウスワトゥン

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    Applicant:丸善製薬株式会社

    Application no:特願2020-106495  Date applied:2020.6.19

    Announcement no:特開2022-001026  Date announced:2022.1.6

    J-GLOBAL

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  • 脂肪蓄積抑制剤及びその製造方法並びに血糖値上昇抑制剤及び腸内細菌叢改善剤

    神崎 浩, 仁戸田 照彦, 畑生 俊光

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    Applicant:国立大学法人 岡山大学

    Application no:特願2020-004396  Date applied:2020.1.15

    Announcement no:特開2021-109865  Date announced:2021.8.2

    J-GLOBAL

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  • 抗酸化性化合物及びそれを含有する組成物の製造方法、並びに、それに用いられる新規微生物

    神崎 浩, 仁戸田 照彦, 徐 恵美, 菊地 敬一

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    Applicant:国立大学法人 岡山大学

    Application no:特願2015-139849  Date applied:2015.7.13

    Announcement no:特開2017-018051  Date announced:2017.1.26

    Patent/Registration no:特許第6609132号  Date registered:2019.11.1 

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  • オリーブ葉抽出物を酵母処理することにより得られる抗酸化物質

    神崎 浩, 仁戸田 照彦, 服部 恭一郎, 吉田 靖弘

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    Applicant:国立大学法人 岡山大学

    Application no:特願2007-039296  Date applied:2007.2.20

    Announcement no:特開2008-201715  Date announced:2008.9.4

    Patent/Registration no:特許第4652355号  Date registered:2010.12.24 

    J-GLOBAL

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  • N-アセチルグルコサミニダーゼ阻害活性を有する化合物

    神崎 浩, 仁戸田 照彦, 奥田 徹, 内田 有紀

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    Applicant:国立大学法人 岡山大学

    Application no:特願2007-035676  Date applied:2007.2.16

    Announcement no:特開2008-195696  Date announced:2008.8.28

    Patent/Registration no:特許第4636623号  Date registered:2010.12.3 

    J-GLOBAL

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  • β-N-アセチルグルコサミニダーゼ阻害活性を有する化合物

    神崎 浩, 仁戸田 照彦, 臼木 博一, 小村 啓, 山路 奈保子

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    Applicant:サントリー株式会社

    Application no:特願2005-364111  Date applied:2005.12.16

    Announcement no:特開2007-161690  Date announced:2007.6.28

    Patent/Registration no:特許第5049489号  Date registered:2012.7.27 

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  • 細胞分裂阻害剤及びその製造方法

    神崎 浩, 加納 周雄, 柳澤 恵広, 仁戸田 照彦, 赤澤 和美

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    Applicant:神崎 浩

    Application no:JP2000006807  Date applied:2000.9.29

    Publication no:WO2001-053290  Date published:2001726

    Patent/Registration no:特許第4810043号  Date registered:2011.8.26 

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  • シアル酸誘導体を含有する医薬組成物

    纐纈 守, 西園 元一, 仁戸田 照彦, 榎木 裕子, 川浪 博司, ジュネジャ レカ ラジュ

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    Applicant:太陽化学株式会社

    Application no:JP1995001415  Date applied:1995.7.14

    Publication no:WO1996-002255  Date published:199621

    Patent/Registration no:特許第3930559号  Date registered:2007.3.16 

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  • ウイルス性下痢治療用組成物

    纐纈 守, 仁戸田 照彦, レカ・ラジュ・ジュネジャ

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    Applicant:太陽化学株式会社

    Application no:特願平5-067498  Date applied:1993.3.2

    Announcement no:特開平6-256195  Date announced:1994.9.13

    Patent/Registration no:特許第3735381号  Date registered:2005.10.28 

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  • シアル酸及びシアル酸誘導体含有組成物の製造方法

    纐纈 守, 佐々木 賢, 川浪 博司, 中田 勝康, 仁戸田 照彦, レカ・ラジュ・ジュネジャ, 藤木 優, 金 武祚

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    Applicant:太陽化学株式会社

    Application no:特願平5-054966  Date applied:1993.2.19

    Announcement no:特開平6-245784  Date announced:1994.9.6

    J-GLOBAL

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Research Projects

  • Microbial conversion of plant resources by three different controlled Koji-mold solid cultivation methods

    Grant number:22H02242  2022.04 - 2026.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    神崎 浩, 仁戸田 照彦

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    Grant amount:\17420000 ( Direct expense: \13400000 、 Indirect expense:\4020000 )

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  • Prediction of substrate specificity of enzymes based on sensitivity to a uniquely selective inhibitor.

    Grant number:21580128  2009 - 2011

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    NITODA Teruhiko

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    Grant amount:\3900000 ( Direct expense: \3000000 、 Indirect expense:\900000 )

    β-N-Acetylhexosaminidase(β-GlcNAcase), an enzyme widely distributed in organisms, is thought to be responsible for numerous physiological processes. However, most of the physiological functions remain to be clarified. The present study revealed that the newβ-GlcNAcase inhibitor TMG-chitotriomycin had the unique selectivity based on the substrate specificity ofβ-GlcNAcase, indicating that TMG-chitotriomycin can be used as a tool for classification ofβ-GlcNAcases differ in substrate specificity and even also in physiological functions.

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  • コンビナトリアルバイオコンバージョンによる新規生理活性物質ライブラリー創製の試み

    Grant number:14656046  2002 - 2003

    日本学術振興会  科学研究費助成事業 萌芽研究  萌芽研究

    神崎 浩, 仁戸田 照彦

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    Grant amount:\3400000 ( Direct expense: \3400000 )

    本来生物が生産しない化合物を生物変換で合成する研究は,生理活性物質生産において幾つか知られている。しかしこのような反応は,目的物が決まった上で選抜されたものであり,ランダムにバイオコンバージョンを行い,その結果得られる化合物群をラィブラリーとする研究はほとんど行われていない。現在の医薬などの生理活性物質探索では,ハイスループットスクリーニング(HTS)が全盛であり,そのための化合物ライブラリーの構築が不可欠とされている。そのためにコンビナトリアル合成が行われているが,これもあくまで構造予測のうえでのライブラリー構築である。そこで,本研究では,2種類の生物の持つ二次代謝産物生産能を組み合わせて,1種の生物では生産不可能な化合物を合成する『コンビナトリアルバイオコンバージョン』という手法の基礎的な検討を行った。我々は既に,糸状菌Aspergillus ustusが生産する細胞分裂阻害物質phenylahistinを放線菌Streptomyces albulusが有している環状ジペプチド脱水素酵素系で処理すると,出発物質のさらに1000倍以上も強力な活性を有する新規化合物dehydrophenylahistinが生成することを明らかにしており,昨年度は,この反応をより効率よく行う技術開発を試み,2種の微生物を寒天培地上で培養し,途中で微生物を移し替える培養法により,目的物質の生産が可能となった。本年度は寒天培養より様々な利点を有する液体培養による方法の確立を試みた。液体振とう培養や,液体静置培養ではPhenylahistinの生産はほとんど見られなかったこと,菌の移し替えを考えると膜状で菌体を生育させるのが望ましいことから,岡山大学工学部中西教授が考案された膜面液体培養による生産を試みたところ,寒天培養より生産性の高い条件が確立できた。以上のことから,寒天培養あるいは膜面液体培養で二種の微生物を培養し,培養途中にそれらを移し替える二段階醗酵により,新規の化合物が生産できると期待される。

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  • Development of reagents for effective genetic modification of plants

    Grant number:09556024  1997 - 1999

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    KANZAKI Hiroshi, OBATA Tokio, NITODA Teruhiro

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    Grant amount:\11400000 ( Direct expense: \11400000 )

    Tow novel geometrical isomers of oxazolomycin, oxazolomycins B (2) and C(3), were isolated from the fermentation broth of an oxazolomycin- producing strain, Streptomyces albus JA3453. The configurations of the triene moieties of 2 and 3 are (4'E, 6'E, 8'E) and (4'Z, 6'E, 8'E), respectively, while that of oxazolomycin (1) is (4'Z, 6'Z, 8'E). 2 and 3 exhibited potent inhibitory activity against crown gall formation with the same MIC (0.8 μg/disk) as oxazolomycin. 2 and 3 showed no antibacterial activity against Agrobacterium tumefaciens, in contrast to oxazolomycin which has specific anti-A. tumefaciens activity. The newly established GUS expression bioassay of the plant callus extracts revealed that the extracts of Phytolacca americana callus had the most potent inhibitory activity against agrobacterial plant transformation. A triterpene glycoside phytolaccoside B was isolated from the extract as a genuine plant transformation inhibitor having neither antiagrobacterial nor phytotoxic activity. We found that the inhibitory activity of oxazolomycin oxazolomycin diacetate against plant transformation was due to its inhibitory effect against the attachment of A. tumefaciens to host plants. Furthermore, oxazolomycin diacetate was found to exhibit an inhibitory activity against the rhicadhesin-mediated agrobacterial attachment to plants, not the biosynthesis of cellulose and β-1, 2-glucan which have been reported to be involved in the agrobacterial attachment. And we found that a novel bacterial acidic polysaccharide from a soil bacterium exhibited plant transformation enhanced plant transformation due to its stimulatory effect for the attachment of A. tumefaciens to host plants.

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  • キチン分解関連酵素阻害剤に関する研究

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    Grant type:Competitive

    昆虫や糸状菌の生育に重要なキチン分解代謝にかかわる酵素の阻害剤の自然界からの探索,得られた阻害剤の化学構造と阻害特異性の相関研究を行なっている。

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  • Search for inhibitors against chitinolytic enzymes

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    Grant type:Competitive

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  • Introduction to Agrochemical Bioscience (2023academic year) Second semester  - 水5~6

  • Course Seminar 1 (2023academic year) 1st and 2nd semester  - 水3

  • Course Seminar 2 (2023academic year) 3rd and 4th semester  - 水3

  • Course Seminar 3 (2023academic year) 1st and 2nd semester  - その他

  • Course Seminar 4 (2023academic year) 3rd and 4th semester  - その他

  • Undergraduate's-level thesis research (2023academic year) 1st-4th semester  - その他

  • Undergraduate's-level thesis research (2023academic year) 3rd and 4th semester  - その他

  • Preliminary training for graduation thesis research 1 (2023academic year) 1st semester  - その他

  • Preliminary training for graduation thesis research 2 (2023academic year) Second semester  - その他

  • Preliminary training for graduation thesis research 3 (2023academic year) Third semester  - その他

  • Preliminary training for graduation thesis research 4 (2023academic year) Fourth semester  - その他

  • Summer Preliminary training for graduation thesis research (2023academic year) Summer concentration  - その他

  • Structural Chemistry of Natural Products (2023academic year) Prophase  - その他

  • Topics in Structural Natural-Product Chemistry (2023academic year) Prophase  - その他

  • Structure Analysis of Organic Compounds 1 (2023academic year) 1st semester  - 木1,木2

  • Structure Analysis of Organic Compounds 2 (2023academic year) Second semester  - 木1,木2

  • Advanced Study (2023academic year) Other  - その他

  • Chemistry and Biochemistry for Bioproducts (2023academic year) Prophase  - 火1,火2

  • Chemistry and Biochemistry for Bioproducts (2023academic year) Prophase  - 火1~2

  • Specific Research of Bioresources Science (2023academic year) Year-round  - その他

  • Seminar in Chemistry of Bioactive Compounds (2023academic year) Prophase  - その他

  • Seminar in Chemistry of Bioactive Compounds (2023academic year) Late  - その他

  • Seminar in Chemistry of Bioactive Compounds (2023academic year) Late  - その他

  • Seminar in Chemistry of Bioactive Compounds (2023academic year) Late  - その他

  • Seminar in Chemistry of Bioactive Compounds (2023academic year) Prophase  - その他

  • Seminar in Chemistry of Bioactive Compounds (2023academic year) Prophase  - その他

  • Seminar in Chemistry of Bioactive Compounds (2023academic year) Year-round  - その他

  • Chemistry of Bioactive Substances 1 (2023academic year) Third semester  - 火3,火4

  • Chemistry of Bioactive Substances 2 (2023academic year) Fourth semester  - 火3,火4

  • Seminars in Special Field of Study 1 (2023academic year) 1st and 2nd semester  - その他

  • Seminars in Special Field of Study 2 (2023academic year) 3rd and 4th semester  - その他

  • Laboratory Agrochemical Bioscience 3 (2023academic year) Third semester  - 月5~8,火5~8,木5~8,金5~8

  • Introduction to Agrochemical Bioscience 1 (2023academic year) Third semester  - 火1,火2

  • Introduction to Agricultural Chemistry 1 (2023academic year) Third semester  - 火1~2

  • Introduction to Agrochemical Bioscience 2 (2023academic year) Fourth semester  - 火1,火2

  • Introduction to Agricultural Chemistry 2 (2023academic year) Fourth semester  - 火1~2

  • Introduction to Agrochemical Bioscience (2022academic year) Second semester  - 水5~6

  • Course Seminar 1 (2022academic year) 1st and 2nd semester  - 水3

  • Course Seminar 2 (2022academic year) 3rd and 4th semester  - 水3

  • Course Seminar 3 (2022academic year) 1st and 2nd semester  - その他

  • Course Seminar 4 (2022academic year) 3rd and 4th semester  - その他

  • Undergraduate's-level thesis research (2022academic year) 1st-4th semester  - その他

  • Preliminary training for graduation thesis research 1 (2022academic year) 1st semester  - その他

  • Preliminary training for graduation thesis research 2 (2022academic year) Second semester  - その他

  • Preliminary training for graduation thesis research 3 (2022academic year) Third semester  - その他

  • Preliminary training for graduation thesis research 4 (2022academic year) Fourth semester  - その他

  • 夏季特別実習 (2022academic year) 夏季集中  - その他

  • Structural Chemistry of Natural Products (2022academic year) Prophase  - その他

  • Structure Analysis of Organic Compounds 1 (2022academic year) 1st semester  - 木1,木2

  • Structure Analysis of Organic Compounds 2 (2022academic year) Second semester  - 木1,木2

  • Chemistry and Biochemistry for Bioproducts (2022academic year) Prophase  - 火1,火2

  • Specific Research of Bioresources Science (2022academic year) Year-round  - その他

  • Seminar in Chemistry of Bioactive Compounds (2022academic year) Prophase  - その他

  • Seminar in Chemistry of Bioactive Compounds (2022academic year) Late  - その他

  • Seminar in Chemistry of Bioactive Compounds (2022academic year) Late  - その他

  • Seminar in Chemistry of Bioactive Compounds (2022academic year) Prophase  - その他

  • Chemistry of Bioactive Substances 1 (2022academic year) Third semester  - 火3,火4

  • Chemistry of Bioactive Substances 2 (2022academic year) Fourth semester  - 火3,火4

  • Seminars in Special Field of Study 1 (2022academic year) 1st and 2nd semester  - その他

  • Seminars in Special Field of Study 2 (2022academic year) 3rd and 4th semester  - その他

  • Laboratory Agrochemical Bioscience 3 (2022academic year) Third semester  - 月5~8,火5~8,木5~8,金5~8

  • Introduction to Agrochemical Bioscience 1 (2022academic year) Third semester  - 火1,火2

  • Introduction to Agricultural Chemistry 1 (2022academic year) Third semester  - 火1~2

  • Introduction to Agrochemical Bioscience 2 (2022academic year) Fourth semester  - 火1,火2

  • Introduction to Agricultural Chemistry 2 (2022academic year) Fourth semester  - 火1~2

  • Agrochemical Bioscience 3 - Organic Chemistry (2021academic year) Second semester  - 水曜日・3,4限

  • Introduction to Agrochemical Bioscience (2021academic year) Second semester  - 水曜日・5,6限

  • Laboratory in Agrochemical Bioscience 3 (2021academic year) Third semester  - 月5,月6,月7,月8,火5,火6,火7,火8,木5,木6,木7,木8

  • Course Seminar 3 (2021academic year) 1st and 2nd semester  - その他

  • 基礎分析化学実験 (2021academic year) 第3学期  - 月5~8,木5~8

  • Structural Chemistry of Natural Products (2021academic year) Prophase  - その他

  • Structure Analysis of Organic Compounds 1 (2021academic year) 1st semester  - 木1,木2

  • Structure Analysis of Organic Compounds 2 (2021academic year) Second semester  - 木1,木2

  • Chemistry and Biochemistry for Bioproducts (2021academic year) Prophase  - 火1,火2

  • Specific Research of Bioresources Science (2021academic year) Year-round  - その他

  • Seminar in Chemistry of Bioactive Compounds (2021academic year) Prophase  - その他

  • Seminar in Chemistry of Bioactive Compounds (2021academic year) Late  - その他

  • Seminar in Chemistry of Bioactive Compounds (2021academic year) Late  - その他

  • Seminar in Chemistry of Bioactive Compounds (2021academic year) Prophase  - その他

  • Chemistry of Bioactive Substances 1 (2021academic year) Third semester  - 火3,火4

  • Chemistry of Bioactive Substances 2 (2021academic year) Fourth semester  - 火3,火4

  • Laboratory Agrochemical Bioscience 3 (2021academic year) Third semester  - 月5~8,火5~8,木5~8,金5~8

  • Course Seminar 3 (2020academic year) 1st and 2nd semester  - その他

  • Course Seminar 4 (2020academic year) 3rd and 4th semester  - その他

  • Structural Chemistry of Natural Products (2020academic year) Prophase  - その他

  • Structure Analysis of Organic Compounds 1 (2020academic year) 1st semester  - 木1,木2

  • Structure Analysis of Organic Compounds 2 (2020academic year) Second semester  - 木1,木2

  • Chemistry and Biochemistry for Bioproducts (2020academic year) Prophase  - 火1,火2

  • Specific Research of Bioresources Science (2020academic year) Year-round  - その他

  • Seminar in Chemistry of Bioactive Compounds (2020academic year) Prophase  - その他

  • Seminar in Chemistry of Bioactive Compounds (2020academic year) Late  - その他

  • Seminar in Chemistry of Bioactive Compounds (2020academic year) Late  - その他

  • Seminar in Chemistry of Bioactive Compounds (2020academic year) Prophase  - その他

  • Chemistry of Bioactive Substances 1 (2020academic year) Third semester  - 火3,火4

  • Chemistry of Bioactive Substances 2 (2020academic year) Fourth semester  - 火3,火4

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