Language：Japanese   Publisher：(株)医学書院  

当院では慢性副鼻腔炎に対する内視鏡下鼻副鼻腔手術(ESS)後の出血予防を目的とした鼻内パッキングにナゾポア(日本ストライカー社)を用いている。今回、2020年12月～2021年12月にナゾポアを使用した46例の成績を報告した。ESSのクリニカルパス逸脱を伴う出血を認めたのは1例のみであり、再手術を要する大出血や重症感染症は認めなかった。ナゾポアに抗菌薬やステロイドを浸潤させることで創傷治癒促進も期待できることから、ナゾポアはESS後の鼻内パッキングに有用と考えられた。

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

PURPOSE: A longitudinal study was conducted to examine the effects of handwashing and gargling education for children on the prevention of respiratory tract infections (RTIs) in children in Japan. METHODS: The study included 38,554 children born in 2010 who were enrolled in a longitudinal study. Information on children's hygiene education regarding handwashing and gargling was collected in a survey at the age of 3.5 years. Based on parents' reports of doctors' diagnoses, airway infections and influenza events in the 12-month duration before the survey were evaluated for RTIs at the ages of 4.5 and 9 years. Poisson regression with robust variance was performed to examine the effects of hygiene education on RTIs prevention. The supplementary analysis was stratified by household income. RESULTS: Children were categorized into different groups: 38% in the handwashing and gargling group, 29% in the handwashing group, 0.1% in the gargling group, and 9.7% in the no-education group. Exclusions were made for non-respondent children (23%) and those in the gargling group. Hygiene education was associated with decreased influenza at the age of 4.5 years in the handwashing (adjusted RR [aRR] = 0.8; 95% CI, 0.8-0.9) and handwashing and gargling groups (aRR = 0.8; 95% CI, 0.8-0.9) compared with no education. However, no preventive effects on airway infections at the age of 4.5 and 9, influenza at the age of 9, or hospitalization between the ages of 3.5 and 9 years were detected. Handwashing and gargling could significantly prevent influenza in low-income households (aRR = 0.7; 95% CI, 0.6-0.8).     Conclusions: Gargling education was widespread and mostly combined with handwashing education in Japan. Hygiene education significantly affected prevention of influenza infections at the age of 4.5 years, especially in low-income households. WHAT IS KNOWN: • Previous intervention studies showed handwashing and gargling are effective in preventing respiratory tract infections. WHAT IS NEW: • We conducted a longitudinal study on handwashing and gargling education in Japanese children and found that handwashing and gargling were widely practiced together. • Handwashing and gargling education were related to a reduction in influenza, particularly in low-income households.

DOI： 10.1007/s00431-023-05062-5

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Other Link： https://link.springer.com/article/10.1007/s00431-023-05062-5/fulltext.html

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

BACKGROUND: Chronic rhinosinusitis (CRS) can be divided into endotypes by functional or pathophysiologic findings. OBJECTIVE: The aim of this study was to analyze the expression of cytokines, prostaglandin (PG) synthases, and their receptors related to the pathogenesis of CRS, especially those contributing to nasal polyp (NP) formation. METHODS: NPs and uncinate tissue (UT) samples were collected from 90 patients who underwent endoscopic sinus surgery. They included 75 patients with CRS (including 45 with eosinophilic CRS [eCRS] and 30 with non-eCRS) and 15 patients without CRS. A total of 30 genes were selected for our original DNA array plate to analyze the levels of expression of 10 cytokines (IFN-γ, IL-4, IL-5, IL-10, IL-13, IL-17A, IL-22, IL-25, IL-33, and TSLP), 4 prostaglandin synthases (prostaglandin D2 [PGD2] synthase, prostaglandin E2 synthase, COX-1, and COX-2), and their 16 receptors. Clustering analysis was performed according to the expression results, and clinical findings of patients from each cluster were investigated. RESULTS: The samples could be divided into 3 clusters. Cluster 1 showed elevated levels of expression of IL4, IL5, IL13, TSLP, IL1RL1 (ST2 [an IL-33 receptor]), HPGDS, and GPR44 (CRTH2, a PGD2 receptor); cluster 2 showed elevated levels of expression of IL17A and PTGES; and cluster 3 showed an elevated level of expression of IL25. Regarding clinical features, the main characteristics of each cluster were as follows: NPs from patients with eCRS for cluster 1, NPs and/or UT samples from patients with non-eCRS for cluster 2, and UTs from patients with non-CRS for cluster 3. CONCLUSION: The results suggest that there are associations between type 2 inflammation/PGD2 and eCRS and also between type 3 inflammation/prostaglandin E2 and non-eCRS.

DOI： 10.1016/j.jacig.2023.100123

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DOI： 10.18926/AMO/64033

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Language：Japanese   Publisher：(株)医学書院  

＜文献概要＞はじめに 流行性耳下腺炎はムンプスウイルスによる感染症であり,耳下腺の腫脹・疼痛や発熱を主症状とする。主に小児期に好発するが,成人発症も少なからず存在する。しばしば感音難聴や髄膜炎,睾丸炎などの合併症を生じるが,咽喉頭浮腫は比較的稀である。過去にも報告例があり1〜20),特に顎下部の腫脹を伴う場合では注意が必要とされている。今回,ムンプスウイルス感染に伴う喉頭浮腫と呼吸困難をきたした症例を経験したので,若干の文献的考察を含め報告する。

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Language：Japanese   Publisher：耳鼻咽喉科臨床学会  

症例は77歳男性で、2週間前頃から喉頭違和感を自覚しており、当科初診日深夜に呼吸困難が出現したため当院に救急搬送された。精査によりたこつぼ型心筋症と狭心症が明らかとなり、さらにCTで気管狭窄を伴う甲状腺腫瘍が認められた。急速に増大する甲状腺腫瘍であったため、未分化癌や悪性リンパ腫を疑い穿刺吸引細胞診を施行したが、検体不良との結果で診断を得られなかった。早期の確定診断に加え、気道管理の面から経皮的な気道確保への移行が必要と判断し、入院4日目に輪状軟骨開窓術と開放生検を同時に行う方針とした。術後2週目にび漫性大細胞性リンパ腫の確定診断に至り、たこつぼ型心筋症と狭心症は呼吸・循環管理により改善していたため、血液内科に転科のうえ術後21日目から化学療法が開始され、6コース完遂後に腫瘍は完全奏効となった。

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Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2022&ichushi_jid=J00580&link_issn=&doc_id=20220705240012&doc_link_id=10.5631%2Fjibirin.115.619&url=https%3A%2F%2Fdoi.org%2F10.5631%2Fjibirin.115.619&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J07551&link_issn=&doc_id=20220628380018&doc_link_id=10.3950%2Fjibiinkotokeibu.125.6_1041&url=https%3A%2F%2Fdoi.org%2F10.3950%2Fjibiinkotokeibu.125.6_1041&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

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DOI： 10.1016/j.alit.2022.03.003

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Background: The total naso-ocular symptom score (TSS) is widely used as an endpoint to evaluate the severity of seasonal allergic rhinitis. However, it is not a generic preference-based measure. We sought to develop an algorithm for mapping between the TSS and health utility in Japanese cedar pollinosis (JCP). We also performed a cost-utility analysis of sublingual immunotherapy (SLIT) for JCP by using this algorithm. Methods: Patients with JCP filled out the TSS questionnaire and EQ-5D-5L simultaneously during the pollen season in 2019 and in 2020. We estimated a direct utility mapping model by regressing responses to individual TSS questions directly onto utility. The incremental cost-effectiveness ratio (ICER) of active SLIT to a placebo was determined by examining the drug expense and the estimated quality-adjusted life year (QALY) using a dataset from a double-blind placebo-controlled clinical trial. Results: A total of 238 records were included for analysis. The estimated utility decreased with increasing severity of rhinitis. Patients with comorbid asthma showed lower utility. A negative and significant correlation was seen between the TSS and utility in both 2019 and 2020. The estimated equations were: Y(utility) = −0.0161∗X(TSS) + 1.005 in non-asthmatic JCP patients. The ICER of active SLIT to the placebo was estimated to be 4,049,720 and 6,011,218 JPY/QALY in the first and second year, respectively. Conclusions: It is possible to reasonably predict utility from the total naso-ocular symptom score by using regression models. In the estimated algorithm, pre-seasonal SLIT for JCP is cost-effective.

DOI： 10.1016/j.alit.2021.11.002

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：MDPI  

Sinonasal inverted papilloma (SNIP) can recur; however, the factors related to tumor recurrence remain unclear. This study aimed to analyze risk factors, including human papillomavirus (HPV) infection, as well as other factors associated with SNIP recurrence. Thirty-two patients who were diagnosed with SNIP and underwent surgery between 2010 and 2019 were enrolled: 24 men and 8 women, with a mean age of 59.2 years. The mean follow-up was 57.3 months. Demographics and information about history of smoking, diabetes mellitus (DM), hypertension, allergic rhinitis, alcohol consumption, tumor stage, surgical approach, and recurrence were reviewed retrospectively. Specimens were investigated using polymerase chain reaction to detect HPV DNA (high-risk subtypes: 16, 18, 31, 33, 35, 52b, and 58; low-risk subtypes: 6 and 11). Seven patients (21.9%) experienced recurrence. HPV DNA was detected in five (15.6%) patients (high-risk subtypes, n = 2; low-risk subtypes, n = 3). Patients with recurrence of SNIP had a higher proportion of young adults and displayed higher rates of HPV infection, DM, and advanced tumor stage than those without recurrence. HPV infection, young adulthood, DM, and advanced tumor stage could be associated with a high recurrence rate, which suggests that patients with these risk factors could require close follow-up after surgery.

DOI： 10.3390/diagnostics12020454

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DOI： 10.1001/jamaoto.2021.3392

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DOI： 10.1016/j.anorl.2021.04.009

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DOI： 10.1007/s00455-020-10196-x

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：TAYLOR & FRANCIS LTD  

BACKGROUND: Several surgical procedures for posterior nasal neurectomy have been reported, but no conclusion has been reached about which procedure is best. OBJECTIVES: The aim is to evaluate the improvement in symptom medication scores for resection of the posterior nasal nerve trunk in an underwater environment, with submucous inferior turbinectomy, without injuring the sphenopalatine artery (SPA) in severe allergic rhinitis. MATERIAL AND METHODS: Improvements in symptom medication scores were retrospectively compared between 27 consecutive cases who underwent resection of the posterior nasal nerve trunk with turbinoplasty in an underwater environment without injuring the SPA (Underwater group) and, as a historical control, 16 consecutive cases who underwent resection of peripheral branches of the posterior nasal nerve with turbinoplasty (Control group). RESULTS: The improvements in symptom medication scores in the Underwater group were significantly better than in the Control group (3.07 vs. 1.96, p = 0.02). CONCLUSIONS AND SIGNIFICANCE: By using underwater posterior nasal neurectomy, we can easily and safely resect the posterior nasal nerve trunk under a clear surgical view without injuring the SPA. This technique with submucous inferior turbinectomy may, more than resection of peripheral branches of the posterior nasal nerve, be able to reduce the medication score and symptom medication score.

DOI： 10.1080/00016489.2021.1925151

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Background: Hyaluronan is one of the major extracellular matrixes in chronic rhinosinusitis (CRS) associated with tissue remodeling. Prostaglandin D2 (PGD2) is also associated with the pathogenesis of CRS. However, little is known about whether PGD2 regulates hyaluronan production by human airway fibroblasts. Objective: We sought to determine the effect of PGD2 on the mRNA expression of three isoforms of membrane-bound hyaluronic acid synthase (HAS1, HAS2 and HAS3) in fibroblasts, the major source of hyaluronan production, derived from CRS patients. Methods: Nasal polyp-derived fibroblasts (NPDF) and uncinate tissue-derived fibroblasts (UTDF) were established from CRS patients with nasal polyps and those without, respectively. These fibroblasts were stimulated with PGD2 or PGD2 receptor (DP/CRTH2)-selective agonists in the presence or absence of receptor-selective antagonists. mRNA levels for HAS1, HAS2 and HAS3 were determined by real-time quantitative PCR. Results: PGD2 (1 µM) significantly enhanced HAS1 but not HAS2 or HAS3 mRNA expression by NPDF. Enhanced HAS1 mRNA expression was also obtained by stimulation with a DP receptor-selective agonist, but not with a CRTH2 receptor-selective agonist. In addition, PGD2-induced HAS1 mRNA expression was significantly inhibited by pre-treatment with DP receptor-selective antagonists. Similar induction of PGD2-induced HAS1 mRNA expression was seen in UTDF. Conclusion: PGD2 selectively stimulates HAS1 mRNA expression in local fibroblasts in CRS via DP, but not CRTH2, receptors.

DOI： 10.1177/1945892420932781

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCI LTD  

OBJECTIVE: Infected mucocele of the paranasal sinuses can induce orbital infection, including orbital subperiosteal abscess, which may lead to life-threatening intracranial complications. Effective diagnosis is important, and treatment should be aggressive. This paper presents our experiences in endoscopic surgical management of orbital complications secondary to infected paranasal sinus mucoceles. METHODS: From our retrospective review of the medical charts for 82 patients with 92 sides diagnosed with paranasal sinus mucoceles, we present 7 sides in 7 adult patients with orbital complications secondary to infected mucoceles. The collected data include the suggested etiology, side of sinus involvement, localization of abscess in the orbit, orbital wall bone defects caused by mucocele compression, ophthalmic symptoms, duration between symptom onset and initial visit, operation date, type of surgery performed, and follow-up. RESULTS: The mucocele was located in the ethmoid-frontal region in 9.8% of the sides (9/92), in the frontal sinus in 7.6% (7/92), in the ethmoidal sinus in 9.8% (9/92), in the maxillary sinus in 67.4% (62/92), in the maxillary-ethmoidal sinus in 3.3% (3/92), and in the sphenoid sinus in 2.2% (2/92). The patients with ethmoid-frontal mucoceles had a significantly higher incidence of orbital complications (6/9) as compared with the other sub-types of mucoceles (frontal, 0/7; ethmoidal, 0/9; maxillary, 1/62; maxillary-ethmoidal, 0/3; sphenoid, 0/2). Chandler's classification showed Type I in one, Type II in three, and Type III in three. Sinus involvement was observed at the ethmoid-frontal sinuses in six cases and the maxillary sinus in one case. All seven cases had a partial defect of the orbital wall bone (lamina papyracea, or inferior orbital wall bone) by mucocele compression, and the patients underwent endoscopic marsupialization. For the cases with subperiosteal abscess, the lamina papyracea was also removed partially for draining the abscess. In all cases, symptoms were resolved without any recurrence of the mucocele. CONCLUSIONS: Infected ethmoid-frontal mucoceles with a defect of the lamina papyracea tend to induce orbital infection, so prompt surgery for the infected mucoceles should be considered early even with Types I and II, before visual acuity is impaired, because surgery is the only curative treatment for the mucoceles.

DOI： 10.1016/j.anl.2020.05.012

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER  

A 70-year-old Japanese man undergoing remission induction therapy for acute monocytic leukemia (AML-M5b) developed fever and headache, and was started on antibiotics and liposomal amphotericin B (L-AMB). There was no improvement, and computed tomography and contrast-enhanced magnetic resonance imaging revealed acute rhinosinusitis and brain abscess. Successful endoscopic endonasal surgery was performed at this point, providing drainage for the rhinosinusitis and abscess. Histopathological findings showed the mucormycosis.

DOI： 10.1016/j.mmcr.2020.09.004

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：LIPPINCOTT WILLIAMS & WILKINS  

HYPOTHESIS: Macrophage migration inhibitory factor plays an important role in the expression of interleukin (IL)-1β and the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in lipopolysaccharide-induced otitis media. BACKGROUND: NLRP3 inflammasome and macrophage migration inhibitory factor are critical molecules mediating inflammation. However, the interaction between the NLRP3 inflammasome and macrophage migration inhibitory factor has not been fully examined. METHODS: Wild-type mice and macrophage migration inhibitory factor gene-deficient (MIF) mice received a transtympanic injection of either lipopolysaccharide or phosphate-buffered saline. The mice were sacrificed 24 hours after the injection. Concentrations of IL-1β, NLRP3, ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain and a pyrin domain), and caspase-1 in the middle ear effusions were measured by enzyme-linked immunosorbent assay. Temporal bones were processed for histologic examination and immunohistochemistry. RESULTS: In the immunohistochemical study using the wild-type mice, positive staining of macrophage migration inhibitory factor, NLRP3, ASC, and caspase-1 were observed in infiltrating inflammatory cells induced by lipopolysaccharide in the middle ear. The number of inflammatory cells caused by lipopolysaccharide administration decreased remarkably in the MIF mice as compared with the wild-type mice. The concentrations of IL-1β, NLRP3, ASC, and caspase-1 increased in the lipopolysaccharide-treated wild-type mice. The MIF mice with lipopolysaccharide had decreased levels of IL-1β, NLRP3, ASC, and caspase-1 as compared with the wild-type mice. CONCLUSION: Macrophage migration inhibitory factor has an important role in the production of IL-1β and the NLRP3 inflammasome. Controlling the inflammation by modulating macrophage migration inhibitory factor and the NLRP3 inflammasome may be a novel therapeutic strategy for otitis media.

DOI： 10.1097/MAO.0000000000002537

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The authors regret that the following two corrections are needed. The authors would like to apologize for any inconvenience caused. 1. The current text for the Authors' Contributions: “MO and KN designed the study and wrote the manuscript. TF, SK, KK, SM and YH contributed to data collection. TH and RO performed the statistical analysis and interpretation of the results”. The correct text should be “KK, MO and KN designed the study and wrote the manuscript. TF, SK, KK, SM and YH contributed to data collection. TH and RO performed the statistical analysis and interpretation of the results”. The underlined initial has been added. 2. The affiliation number of the last author “Kazunori Nishizaki” was mentioned incorrectly as “b”. The correct affiliation should be “a”.

DOI： 10.1016/j.alit.2019.11.001

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：W B SAUNDERS CO-ELSEVIER INC  

Purpose: Chronic cough is a common complaint. Because the pathophysiology of chronic cough is complicated, the management of chronic cough is challenging. To the best of our knowledge, no previous study has examined the effect of macrolide antibiotics in chronic cough patients with chronic rhinosinusitis. The purpose of this study is to determine the changes in lung function for chronic cough patients with chronic rhinosinusitis who are treated by clarithromycin and carbocisteine.Materials and methods: Thirty-two chronic cough patients with chronic rhinosinusitis were recruited. Patients using inhaled corticosteroids and/or a bronchodilator, asthmatic patients, and patients with abnormal findings on auscultation and/or chest X-ray examination were excluded from this study. The patients received low-dose clarithromycin treatment for 3 months. Both before and after the treatment, a computed tomography (CT) scan of the paranasal sinuses, lung function test, peripheral blood test, and sino-nasal outcome test (SNOT-20) were applied.Results: Both the lung function and Lund-MacKay CT scores were improved by the long-duration therapy with macrolide antibiotics. The change in obstructive pulmonary function and the improvement of the CT score in each subject were significantly correlated. SNOT scores also improved after the treatment.Conclusions: The macrolide antibiotics treatment has beneficial effects on lung function in non-asthmatic chronic cough patients with normal chest X-ray findings. The improvement of chronic rhinosinusitis may have some role in the lung condition. Upper respiratory tract examination and treatment may be useful for the management of chronic cough.

DOI： 10.1016/j.amjoto.2019.102315

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：SAGE PUBLICATIONS INC  

Perforation of the larynx is very rare but may result in severe airway complications that include pneumothorax, pneumonia, mediastinitis, and retropharyngeal abscess. If conservative treatment fails, aggressive treatments including reconstructive surgery with pedicle flap are considered. Negative pressure wound therapy has been used for large skin defects, necrotizing fasciitis, pharyngocutaneous fistula, stoma dehiscence, osteoradionecrosis of the mandible, chyle fistula, flap failure, and lymphangioma in the field of head and neck surgery. We report a case of false vocal cord perforation with abscess successfully treated by negative pressure wound therapy after abscess treatment. The result suggests that negative pressure wound therapy can be an alternative or adjunctive approach for larynx perforation when the perforation is difficult to close after conservative therapy.

DOI： 10.1177/2050313X20915415

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCI LTD  

As has been well recognized, methotrexate (MTX) leads to a state of immunosuppression and can provide a basis for the development of lymphoproliferative disorders (LPDs). MTX-associated LPDs can affect nodal sites as well as extranodal sites, though the manifestation of an LPD in the form of multiple pulmonary nodules is rare. Here, we report two cases of MTX-associated LPD with multiple bilateral pulmonary nodules, which was a finding suggestive of lung cancer, and bilateral cervical lymphadenopathy. After withdrawal of MTX, the multiple bilateral pulmonary nodules and bilateral cervical lymphadenopathy disappeared without chemotherapy in both cases. From these results, patients with pulmonary nodules and cervical lymphadenopathy should be examined for head and neck malignant tumors. Also, physicians should carefully check the administration of MTX. In patients with an MTX-associated LPD, we need to make an early diagnosis and consider discontinuing the administration of MTX as soon as possible.

DOI： 10.1016/j.anl.2019.01.010

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCI LTD  

OBJECTIVE: The treatment of all forms of sinonasal inverted papilloma (IP) is a complete, wide, local resection. The main surgical purpose is to remove all diseased mucosa and mucoperiosteum, together with a cuff of normal-looking mucosa at the attachment site, followed by drilling and/or coagulation. Our aim is to present our experiences in endoscopic surgical management of IP by using attachment-oriented excision. METHODS: We present 20 cases of sinonasal IP. The data collected includes the histopathological diagnosis, staging, extension of the tumor, tumor attachment site, approach to surgery, serum squamous cell carcinoma antigen (SCCA) level, and recurrences. RESULTS: All patients underwent endoscopic surgery. A Caldwell-Luc operation was required in addition to the endoscopic surgery in one case. There was one case of recurrence (5%). After the additional operation, there was no recurrence. The tumor attachment sites vary, and the case of recurrence had a wide attachment site at the primary surgery. No major intra- or post-operative complications were observed. CONCLUSION: The present study shows that attachment-oriented excision for IP is useful for complete resection of IP. Surgeons should choose the surgical approach according to the location of the tumor attachment site rather than the Krouse staging system.

DOI： 10.1016/j.anl.2019.02.007

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY  

Swallowing syncope is a rare medical condition. Even though it has been known as a neurally mediated syncope, the definitive mechanism of this condition remains unclear. We show in this study an additional case of swallowing syncope and review the 122 reported cases from the literature. A 47-year-old Japanese man had been suffering from recurrent syncopal attacks, when he fainted immediately after swallowing. Holter electrocardiogram monitoring demonstrated a sinus pause (maximum R-R interval of 3.8 seconds) after he swallowed a noodle quickly. A permanent pacemaker was implanted because the frequency of syncope increased.

DOI： 10.1002/joa3.12130

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

: Prophylactic treatment with intranasal corticosteroids is effective for pollen-induced seasonal allergic rhinitis. However, the appropriate time to start this treatment remains unclear. We performed a double-blinded, randomized, placebo-controlled trial. Starting on February 1, 2014, patients with Japanese cedar pollinosis received either fluticasone furoate nasal spray (FFNS) for 8 weeks (Group A: n = 24), placebo nasal spray for 2 weeks followed by FFNS for 6 weeks (Group B: n = 23), or placebo for 4 weeks followed by FFNS for 4 weeks (Group C: n = 23). The primary endpoint was comparison of the total naso-ocular symptom score (TSS). Secondary endpoints including the increment cost effective ratio (ICER) were also determined. Continuous pollen dispersion began on the 24th of February. Therefore, Group A and Group B received 3-weeks and 1-week of prophylactic treatment, respectively, whereas Group C received post-onset treatment. During the peak pollen-dispersal period, significant differences in TSS were seen between the groups, particularly between Group A and C. The ICER of Group B vs. Group C was lower than that of Group A vs. Group C. These results suggest that long-term prophylactic treatment with FFNS is clinically the most potent treatment, whereas short-term prophylactic treatment is cost effective for pollen-induced allergic rhinitis.

DOI： 10.3390/medsci7010011

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BACKGROUND: The frontal recess and sinus are the most likely areas for sinus surgery failure. A significant difference between races in the anatomical structure of paranasal sinuses has been reported. The axillary flap approach is one of the surgical techniques of endoscopic sinus surgery (ESS) that can improve access to the frontal recess. In this study, we examined the usefulness of the axillary flap approach to accessing the frontal recess and sinus by identifying the frontal ostium during ESS in Japanese patients. METHODS: We performed ESS with the axillary flap approach on 38 patients (59 sides). Demographic data, identification of the frontal ostium, surgical findings, preoperative and postoperative symptoms, incidence of revision surgery, and postoperative complications were collected. RESULTS: The frontal sinus ostium was identified in 96.6% (57 of 59) of the sides. All of the frontal sinus cells detected in a preoperative CT scan were identified during ESS with the axillary flap approach without using a 70-degree endoscope. The symptoms significantly improved after ESS. Three sides had middle meatal adhesions after ESS that required surgical repair under local anesthesia. There was no major postoperative complication such as cerebrospinal fluid leak, orbital injury, or hemorrhage requiring blood transfusion. No patient required revision ESS. CONCLUSIONS: The axillary flap technique is a safe and simple surgical procedure that provides excellent access to the frontal recess without using a 70-degree endoscope, even in Japanese patients. It allows clearance of cells in the recess with identification of the frontal ostium, leading to successful ESS.

DOI： 10.23736/S0392-6621.19.02224-0

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OBJECTIVE: The agger nasi cell (ANC) is an easily identifiable landmark when approaching the frontal sinus. The success of endoscopic frontal sinus surgery may be influenced by the width of the frontal recess (FR). The aim of this study is to examine the relationship between the FR width and the ANC size in Japanese patients. In addition, the effect of various frontal recess cells (FRCs) on the development of frontal sinusitis has been examined. MATERIALS AND METHODS: Multiplanar computed tomography (CT) scans of the nasal cavities and paranasal sinuses in 95 patients (190 sides) before endoscopic sinus surgery were reviewed. The presence of FRCs, the thickness of the frontal beak (FB), the ANC size, and the anterior-to-posterior (A-P) length of the frontal isthmus (FI) and FR were evaluated in patients with and without frontal sinusitis. RESULTS: The prevalence of the ANC, frontal cell types 1, 2, 3, and 4, frontal bullar cell (FBC), suprabullar cell, supraorbital ethmoid cell, and interfrontal sinus septal cell was 85.3%, 11.6%, 0%, 7.9%, 0%, 25.3%, 45.8%, 16.8%, and 15.3%, respectively. The ANC volume showed a significant positive correlation with the A-P length of the FI and FR. The incidence of frontal sinusitis in the patients with FBCs was significantly higher than that without FBCs. CONCLUSION: A large ANC offers a greater potential to facilitating the approach to the frontal sinus because of the extensiveness of the FR in Japanese patients. The presence of FBCs may be related to a higher incidence of frontal sinusitis.

DOI： 10.1177/1179550619884946

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BACKGROUND: Allergic fungal rhinosinusitis (AFRS) is a noninvasive fungal disease of the sinuses with a very high recurrence rate. A very small number of Japanese cases have been reported. MATERIAL AND METHODS: The subjects were 6 patients with AFRS out of 429 patients who underwent endoscopic sinus surgery at Kagawa Rosai Hospital between December 2011 and November 2017. We retrospectively examined the clinical features and outcomes of these 6 patients. RESULTS: The incidence of AFRS was 1.4% (6/429). Allergic fungal rhinosinusitis was unilateral in 5 cases and bilateral in 1. Computed tomography revealed hyperdense areas representing allergic mucin, but no patient exhibited bone erosion. Magnetic resonance imaging showed hypointense or no signal regions at the locations of allergic mucin. Postoperatively, 1 patient developed recurrence. Because the recurrent patient had no significant symptoms, he refused further surgery and received drug therapy. Preoperative eosinophil counts and total IgE levels were elevated in all patients; postoperatively, both remained high in the patient who developed recurrence. Postoperative treatments included steroid therapy and nasal irrigation. CONCLUSIONS: Allergic fungal rhinosinusitis is less prevalent in Japan than in Western nations. Peripheral blood eosinophil and serum IgE values may be used as the biomarkers. SIGNIFICANCE: Allergic fungal rhinosinusitis is prone to recurrence. Postoperative treatment including steroid therapy is important in the management of AFRS.

DOI： 10.1177/1179550619870758

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：KARGER  

BACKGROUND: The histological changes corticosteroids induce in nasal polyps, and whether these changes have an impact on the diagnosis of eosinophilic chronic rhinosinusitis (ECRS), currently remain unclear. OBJECTIVES: A prospective controlled multicenter trial was conducted to evaluate the efficacy of the low-dose and short-term oral prednisolone (oPSL) treatment for tissue eosinophil infiltrations in ECRS. METHODS: Subjects with ECRS diagnosed by previous biopsies received a low dose of oPSL for 3 days (PSL 3) or 7 days (PSL 7) before surgery. Changes in the tissue eosinophil count after these treatments were evaluated. Furthermore, the percent change of tissue eosinophil count from baseline and its impact on the diagnosis defined by the JESREC study were examined. RESULTS: There were 23 and 21 subjects in the PSL 3 and PSL 7 groups, respectively. Polyp scores, clinical symptom scores, and the proportion of blood eosinophils significantly decreased after the treatment, and no significant differences were observed between the groups. The entire tissue eosinophil count tended to be slightly decreased in both groups without reaching a statistically significant value. The median percent change of tissue eo-sinophil count from baseline was 83.6%, and only the posttreatment proportion of blood eosinophil showed a mild correlation with it. Seven out of 44 nasal polyp specimens collected from the superficial part of the middle meatus showed < 70 eosinophils/high-power field; therefore, the false negative rate was 15.9%, but decreased to 11.4% when other parts were included in the histological evaluation. CONCLUSIONS: Low-dose and short-term oPSL did not appear to markedly affect the tissue eosinophil count in ECRS patients; however, the potential for misdiagnoses due to the effects of oPSL cannot be rejected. The diagnosis of ECRS prior to the administration of corticosteroids or tissue evaluations using multiple tissue parts is desirable.

DOI： 10.1159/000496437

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BACKGROUND: The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is a critical molecule mediating interleukin-1β (IL-1β) responses. However, the role of the NLRP3 inflammasome in otitis media has not been fully examined. AIMS/OBJECTIVES: The purpose of this study is to assess the expression of NLRP3, ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain and a pyrin domain), and caspase-1 in lipopolysaccharide-induced otitis media. MATERIALS AND METHODS: BALB/c mice received a transtympanic injection of either lipopolysaccharide or phosphate-buffered saline. The mice were sacrificed 24 h after injection. Concentrations of IL-1β, NLRP3, ASC, and caspase-1 in the middle ear effusions were measured by enzyme-linked immunosorbent assay. Temporal bones were processed for histologic examination and immunohistochemistry. RESULTS: The transtympanic injection of lipopolysaccharide significantly upregulated levels of IL-1β, NLRP3, ASC, and caspase-1 in the middle ear as compared with the control mice. The proteins of NLRP3, ASC, and caspase-1 were observed in infiltrating inflammatory cells induced by lipopolysaccharide in the middle ear cavity. CONCLUSIONS AND SIGNIFICANCE: Lipopolysaccharide induces NLRP3 inflammasome components in the middle ear. The NLRP3 inflammasome may play an important role in the pathogenesis of otitis media. Modulation of inflammasome-mediated inflammation may be a novel therapeutic strategy for otitis media.

DOI： 10.1080/00016489.2018.1515499

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The authors have brought to our attention that an incorrect affiliation was supplied for Yorihisa Orita, Kentaro Miki, Iku Abe–Fujisawa, and Kazunori Nishizaki. All authors and their corrected affiliations appear below. Tomoyasu Tachibana, MD, 1 Yorihisa Orita, MD, PhD, 2 Hidenori Marunaka, MD, 3 Seiichiro Makihara, MD, PhD, 4 Misato Hirai, MD, PhD, 5 Kentaro Miki, MD, 2 Yuya Ogawara, MD, 1 Hisashi Ishihara, MD, 4 Yuko Matsuyama, MD, 1 Iku Abe–Fujisawa, MD, 2 Aiko Shimizu, MD, 1 Yasuharu Sato, MD, PhD, 6 Kazunori Nishizaki, MD, PhD 21 Department of Otolaryngology, Himeji Red Cross Hospital, Hyogo, Japan, 2 Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, 3 Department of Otolaryngology, Okayama Medical Center, Okayama, Japan, 4 Department of Otolaryngology, Kagawa Rosai Hospital, Kagawa, Japan, 5 Department of Otolaryngology, Okayama Saiseikai General Hospital, Okayama, Japan, 6 Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

DOI： 10.1002/hed.25196

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：JAPANESE SOCIETY ALLERGOLOGY  

BACKGROUND: IL-10 is a major anti-inflammatory cytokine that prevents inflammation-mediated tissue damage. We characterized the production of IL-10 by sinonasal tissue cells following exposure to Staphylococcus aureus enterotoxin B (SEB), which elicits cellular responses and is associated with the pathogenesis of eosinophilic chronic rhinosinusitis (ECRS). METHODS: Dispersed nasal polyp (NP) cells and uncinate tissue (UT) cells were prepared from patients with CRS with and without NP, respectively. Cells were incubated with SEB, and then the levels of IL-10 in the cell supernatants were determined. The effect of neutralizing IL-10 on SEB-induced IL-5, IL-13, IFN-γ, and IL-17A production was examined. Expression of IL-10 in NPs was also determined. RESULTS: IL-10 was expressed in infiltrating inflammatory cells in NPs. NP cells, especially non-adherent NP cells, produced substantial amounts of IL-10 in response to SEB. Although baseline production of IL-10 was significantly higher in NP cells than UT cells, the degree of IL-10 response to SEB was not significantly different between the cell types. The degree of IL-10 production was negatively correlated with the degree of eosinophilia both in tissues and peripheral blood whereas positively correlated with the 1-s forced expiratory volume/forced vital capacity ratio. Patients with severe ECRS displayed a significant decrease in IL-10 production compared with those with non-ECRS. IL-10 neutralization significantly augmented SEB-induced IL-13 and IFN-γ production by NP cells. CONCLUSIONS: Impaired IL-10 production in response to SEB in NP may exacerbate the pathophysiology of ECRS including eosinophilia and lower airway obstruction.

DOI： 10.1016/j.alit.2018.02.001

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Objectives: Unlike glottic cancer, supraglottic cancer often presents with neck metastases. This different might be attributable to the location of the primary lesion. This study aimed to clarify the relationships between the sublocation of T1-2 supraglottic cancer, human papillomavirus (HPV) infection, neck metastasis, and prognosis of supraglottic cancer. Methods: This retrospective clinical study investigated 55 Japanese patients with T1-2 supraglottic cancer treated between 1994 and 2015. Results: Of 55 patients with T1-2 supraglottic cancer, neck metastasis was present at initial diagnosis in 14 patients (25.5%). Presence of neck metastasis was the only factor associated with worse prognosis of T1-2 supraglottic cancer (p = 0.004). In multivariate analysis, age <70 years (p = 0.033) and sublocation of the primary lesion in the superior epilaryngeal portion (p = 0.017) were significantly associated with presence of neck metastasis in multivariate analysis. Twelve (27.9%) of 43 patients showed positive results for human papillomavirus infection. However, human papillomavirus infection was not associated with prognosis, presence of neck metastasis, or primary lesion sublocation in T1-2 supraglottic cancer. Conclusion: Relatively young patients with supraglottic cancer at the superior epilaryngeal portion are more likely to show neck metastasis. Human papillomavirus infection was not associated with frequency of neck metastasis.

DOI： 10.1016/j.anl.2017.06.002

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCI LTD  

OBJECTIVE: There is a close relationship between upper and lower respiratory tract diseases. Chronic rhinosinusitis patients frequently have lung diseases including asthma and chronic obstructive pulmonary disease. Eosinophilic chronic rhinosinusitis is considered a refractory and intractable subtype of chronic rhinosinusitis. However, there has been no report on pulmonary function in patients with eosinophilic chronic rhinosinusitis. The purpose of this study is to examine the pulmonary function in eosinophilic chronic rhinosinusitis patients and non-eosinophilic chronic rhinosinusitis patients, and evaluate clinical factors associated with the pulmonary function of these patients. METHODS: Pulmonary function was measured in 53 patients with eosinophilic chronic rhinosinusitis with asthma, 58 patients with eosinophilic chronic rhinosinusitis without asthma, and 30 patients with non-eosinophilic chronic rhinosinusitis. The diagnosis of chronic rhinosinusitis was based on the definition in the European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS) 2012. Eosinophilic chronic rhinosinusitis was diagnosed based on the Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) scoring system. The relationship between pulmonary function and clinical parameters was assessed. These parameters included radiographic severity of chronic rhinosinusitis, peripheral blood eosinophil percentage, serum total immunoglobulin E level, and eosinophilic infiltration in nasal polyps. RESULTS: The pulmonary function of the patients with eosinophilic chronic rhinosinusitis was significantly affected. The eosinophilic chronic rhinosinusitis patients had more peripheral airway obstruction as compared to the patients with non-eosinophilic chronic rhinosinusitis. CONCLUSION: Our findings indicated latent obstructive lung function changes in the eosinophilic chronic rhinosinusitis patients. The patients with eosinophilic chronic rhinosinusitis should be carefully monitored in order to detect lung diseases.

DOI： 10.1016/j.anl.2017.07.020

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OBJECTIVE: To delineate the association between characteristics of adult-onset laryngeal squamous cell papilloma and human papillomavirus (HPV) infection. METHODS: Clinical records and paraffin-embedded specimens of 77 papilloma patients who had been treated between 1998 and 2014 were collected. Of the 77 cases, 34 were identified in the larynx, 28 in the oral cavity and 15 in the oropharynx. Specimens were investigated by polymerase chain reaction (PCR) to detect HPV 6, 11, 16, 18, 31, 33, 35, 52b and 58, and immunohistochemical (IHC) staining for anti-p16INK4a antibody. RESULTS: In 21 cases (61.8%) with laryngeal squamous cell papilloma, various types of HPV were detected: 14 cases (41.2%) were positive of high-risk HPV, 18 (52.9%) were positive of low-risk HPV and 11 (32.4%) were positive of both high-risk HPV and low-risk HPV. Younger patients (<60 years) showed a higher rate of HPV infection than older patients. Among the 34 cases with laryngeal papilloma, no malignant transformation was observed during the study period. With IHC staining, positive expression of p16 was observed in 20 cases (58.8%). HPV infection and p16-expression were associated with the pathological finding of koilocytosis. Only four cases (14.3%) showed HPV-positivity in the oral cavity, and none of the 15 oropharyngeal cases were positive for HPV, and none of the oral cavity and oropharyngeal cases showed koilocytosis. Results of HPV-PCR and p16-IHC staining were significantly correlated each other. CONCLUSIONS: HPV infection is frequently associated with laryngeal squamous cell papilloma, and koilocytosis is a characteristic pathological finding. To the best of our knowledge, this is the first report which have described infections with multiple HPV types in laryngeal papilloma.

DOI： 10.1093/jjco/hyy009

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPRINGER JAPAN KK  

DOI： 10.1016/j.jos.2015.09.001

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Background IL-22 is an IL-10-family cytokine that regulates chronic inflammation. We investigated the role of IL-22 and its receptor, IL-22R1, in the pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNP). Methods IL-22 and IL-22R1 protein and mRNA expression in NP and in uncinate tissues (UT) from CRS and non-CRS patients was examined using immunohistochemistry and real-time PCR, respectively. Dispersed NP and UT cells were cultured with the Staphylococcus aureus exotoxins, staphylococcal enterotoxin B and alpha-toxin, following which exotoxin-induced IL-22 levels and their association with clinicopathological factors were analyzed. Effects of IL-22 on MUC1 expression and cytokine release in NP cells were also determined. Results IL-22 and IL-22R1 in NP were mainly expressed in infiltrating inflammatory cells and in epithelial cells, respectively. IL-22 mRNA levels in NP were significantly higher than those in UTs from non-CRS patients whereas IL-22R1 levels were conversely lower in NPs. NP cells produced substantial amounts of IL-22 in response to exotoxins. Exotoxin-induced IL-22 production by NP cells significantly and negatively correlated with the degree of local eosinophilia and postoperative computed tomography (CT) score, whereas conversely it positively correlated with the forced expiratory volume in 1s (FEV1)/forced vital capacity (FVC) ratio. IL-22 significantly enhanced MUC1 mRNA expression in NP cells. IL-22-induced MUC1 mRNA levels were significantly and positively correlated with IL-22R1 mRNA levels in NPs. Conclusions These data suggest that imbalance of IL-22/IL-22R1 signaling regulates the pathogenesis of CRSwNP, including local eosinophilia, via alteration of MUC1 expression.

DOI： 10.1016/j.alit.2016.04.017

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Objective: In 2013, the Japanese Rhinologic Society proposed a simple classification for endoscopic sinus surgery (ESS). This classification consists of five procedures (type I, fenestration of the ostiomeatal complex, with uncinectomy and widening of the natural ostium; type II, single-sinus procedure, with manipulating the inside of the sinus; type III, polysinus procedure; type IV, pansinus procedure; type V, extended procedure beyond the sinus wall). The clinical relevance of this classification in chronic rhinosinusitis (CRS) and paranasal sinus cyst was evaluated. Study Design: A retrospective validation study. Methods: A total of 122 patients (195 sinuses) who underwent ESS in Okayama University Hospital in 2012 were enrolled. The relationships between the ESS classification and the clinical course, including the operation time, bleeding amounts during surgery and postoperative changes of olfaction, the computed tomography (CT) score, and nasal airway resistance were analyzed. Results: A total of 195 ESS procedures were classified into type I (n = 3), type II (n = 17), type III (n = 91), type IV (n = 82), and type V (n = 2). The major phenotypes of type II, III, and IV ESS were paranasal sinus cyst (68%), CRS without nasal polyps (77%), and CRS with nasal polyps (55%), respectively, and the difference was significant. The degree of ESS based on this classification was positively and significantly correlated with the operation time and bleeding amounts. As a whole, olfaction, CT score, and nasal airway resistance were significantly improved after surgery. The degree of improvement was similar between type III and type IV ESS. Conclusion: This simple classification for ESS reflected the perioperative burden of the disease.

DOI： 10.2500/ar.2017.8.0208

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Background Vascular endothelial growth factor (VEGF) is known to be associated with the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). VEGF is produced by a variety of cells including fibroblasts. It was recently reported that prostaglandin (PG) E2 induces VEGF release by nasal polyp fibroblasts. However, little is known regarding possible regulation of VEGF by other PGs. We have reported that molecules that regulate PGD2 metabolism play roles in the pathogenesis of CRS including in local eosinophilia and type 2 cytokine production. In the present study, we sought to determine whether PGD2 regulates VEGF release by nasal polyp fibroblasts. Methods Nasal polyp fibroblasts were established from nasal polyps. These fibroblasts were stimulated with serial dilutions of PGD2 or PGD2 receptor (DP/CRTH2)-selective agonists in the presence or absence of receptor-selective antagonists. The concentration of VEGF in the culture supernatants was determined using ELISA. Results 5 μM of PGD2 significantly induced VEGF release by nasal polyp fibroblasts. VEGF release was also obtained by stimulation with a DP receptor-selective, but not with a CRTH2 receptor-selective agonist. In addition, PGD2-induced VEGF release was significantly inhibited by pre-treatment with DP receptor-selective antagonists. In contrast, pre-treatment with a CRTH2 receptor-selective antagonist significantly enhanced PGD2-induced VEGF release. Conclusions PGD2 stimulates VEGF production via DP but not CRTH2 receptors in nasal polyp fibroblasts.

DOI： 10.1016/j.alit.2016.03.003

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Language：Japanese  

Brainstem/cerebellar infarction is known to cause various cranial nerve symptoms that may require otorhinolaryngological evaluation. Acute-phase cerebellar infarction is evaluated by MRI with diffusion-weighted imaging (MRI-DWI). However, in the acute phase, MRI-DWI may show false-negative results, because of which patients are referred to the department of otolaryngology for further evaluation of the cranial nerve symptoms. We investigated 250 cases of brainstem/cerebellar infarction in 245 patients who were admitted to our hospital between 2010 and 2015. Of the 250 cases, eight cases were diagnosed at the department of otolaryngology after detailed evaluators for dizziness or dysphagia, and three of them were false negative on initial MRI-DWI. In total, we examined 16 cases detected as false negatives upon initial MRI-DWI. Of the 16 cases, 12 were brainstem infarctions, three were cerebellar infarctions, and one was infarction of the brainstem and cerebellum. All 16 cases were evaluated by initial MRI-DWI within 12 h of onset. Careful observation of the neurological findings and follow-up MRI-DWI are useful for the detailed evaluation of patients suspected to have a cerebellar infarction.

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Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2016&ichushi_jid=J01099&link_issn=&doc_id=20161114550003&doc_link_id=%2Fdz0jibik%2F2016%2F011910%2F003%2F1290-1299%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdz0jibik%2F2016%2F011910%2F003%2F1290-1299%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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Background Minimal persistent inflammation (MPI) contributes to hyperreactivity in allergic rhinitis. However, little is known regarding whether pre-onset activation of eosinophils and mast cells is present or not in Japanese cedar pollinosis (JCP). Furthermore, a prophylactic effect of intranasal corticosteroids on such MPI in JCP has not been investigated. Methods We designed a double-blinded, randomized, placebo-controlled, crossover trial. Twenty patients with JCP were examined outside the pollen season (UMIN000008410). Nasal provocation with paper discs containing extracts of Japanese cedar pollen was performed once a day for 3 consecutive days. Onset of nasal symptoms was monitored over 15 min after each provocation. The levels of eosinophil cationic protein (ECP) and tryptase in nasal secretions were examined. Fluticasone furoate nasal spray or placebo treatment was started one day before the first provocation. Results In the placebo group, 25% of the patients showed onset of nasal symptoms following provocation on the first day. In addition, 75% and 68% of the patients showed symptom onset on the second and third day of provocation, respectively. After the first provocation, the levels of ECP and tryptase in nasal secretions were significantly increased. These increases were seen not only in symptomatic but also in asymptomatic subjects in response to provocation, and the levels were similar between these subjects. Prophylactic treatment with fluticasone significantly suppressed the increase in nasal ECP and tryptase associated with repeated provocations. Conclusions These results suggest that pre-onset activation of eosinophils and mast cells is present in experimental JCP, and that prophylactic treatment with intranasal corticosteroids has the potential to control such activation.

DOI： 10.1016/j.alit.2015.12.007

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY-BLACKWELL  

BACKGROUND: Few studies have investigated the clinical characteristics of patients with glottic cancer without hoarseness. METHODS: This retrospective clinical study investigated 371 patients with glottic cancer. RESULTS: Thirty-two of the 371 patients (8.6%) with glottic cancer first presented to hospitals with complaints other than hoarseness. Although proportions of stage I and T1 disease were significantly higher among patients without hoarseness than among those with hoarseness (p = .0036 and p = .0004, respectively), survival curves showed no significant differences between groups (p = .1334). CONCLUSION: Patients with glottic cancer without complaints of hoarseness were diagnosed at an earlier stage than those with hoarseness. Accumulation of more cases may lead to better survival of patients with glottic cancer without hoarseness compared to those with hoarseness. Checking the larynx of patients without hoarseness or encouraging internists to check the larynx when performing gastroscopic or respiratory examinations may lead to improvement of glottic cancer prognosis. © 2015 Wiley Periodicals, Inc. Head Neck 38: E316-E320, 2016.

DOI： 10.1002/hed.23992

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Background Toll-like receptor 3 (TLR3) is expressed in upper airways, however, little is known regarding whether Toll-like receptor 3 (TLR3) signals exert a regulatory effect on the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP), especially on eosinophilic inflammation. We sought to investigate the effect of Poly(IC), the ligand for TLR3, on cytokine production by dispersed nasal polyp cells (DNPCs). Methods DNPCs were pretreated with or without Poly(IC), and were then cultured in the presence or absence of staphylococcal enterotoxin B (SEB), following which the levels of IL-5, IL-10, IL-13, IL-17A and interferon (IFN)-γ in the supernatant were measured. To determine the involvement of IL-10 and cyclooxygenase in Poly(IC)-mediated signaling, DNPCs were treated with anti-IL-10 monoclonal antibody and diclofenac, the cyclooxygenase inhibitor, respectively. Poly(IC)-induced prostaglandin E2 (PGE2) production was also determined. Results Exposure to Poly(IC) induced a significant production of IL-10, but not of IL-5, IL-13, IL-17A or IFN-γ by DNPCs. Pretreatment with Poly(IC) dose-dependently inhibited SEB-induced IL-5, IL-13 and IL-17A, but not IFN-γ production. Neutralization of IL-10 significantly abrogated the inhibitory effect of Poly(IC). Treatment with diclofenac also abrogated the inhibitory effect of Poly(IC) on SEB-induced IL-5 and IL-13 production. However, unlike exposure of diclofenac-treated DNPCs to lipopolysaccharide, the ligand for TLR4, exposure of these cells to Poly(IC) did not enhance IL-5 or IL-13 production. Poly(IC) did not significantly increase PGE2 production by DNPCs. Conclusions These results suggest that TLR3 signaling regulates eosinophilia-associated cytokine production in CRSwNP, at least in part, via IL-10 production.

DOI： 10.1016/j.alit.2015.08.005

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Background Recent studies have revealed that Staphylococcus aureus and its components participate in the pathogenesis of eosinophilic airway diseases, such as chronic rhinosinusitis with nasal polyps. Objective We sought to determine whether staphylococcal protein A (SpA) from S aureus regulated cellular responses in nasal polyps, especially when coupled to immunoglobulins in immune complexes (ICs). Methods Dispersed nasal polyp cells (DNPCs) or peripheral blood monocytes were cultured in vitro with SpA in the presence or absence of IgG, and IL-5, IL-13, IFN-γ, IL-17A, and IL-10 levels were measured in the supernatants. The effect of SpA exposure on staphylococcal enterotoxin B-induced cytokine production by DNPCs in the presence and absence of IgG, IgA, and autologous serum was also examined. Results Exposure to SpA induced DNPCs to produce significantly higher IL-10, IL-13, and IL-17A levels than DNPCs without SpA, although the magnitude of the IL-17A increase was less than that of IL-10 and IL-13. SpA induced IL-10 production mainly from adherent DNPCs, and this was significantly enhanced in the presence of IgG; similar results were observed in peripheral blood monocytes. IC formation between SpA and IgG (SpA-IgG ICs) was confirmed by using native polyacrylamide gel electrophoresis. SpA-IgG ICs, but not SpA alone, almost completely suppressed staphylococcal enterotoxin B-induced IL-5, IL-13, IFN-γ, and IL-17A production by DNPCs; similar inhibition was observed in DNPCs treated with SpA in the presence of either IgA or autologous serum. Conclusions Our results suggest that SpA can regulate the pathogenesis of enterotoxin-induced inflammation in patients with chronic rhinosinusitis with nasal polyps through coupling to immunoglobulins.

DOI： 10.1016/j.jaci.2014.10.058

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：TAYLOR & FRANCIS LTD  

CONCLUSION: It appears that patients with SCCHN should be recommended to take S-1 for more than 1 year and, if possible, more than 2 years, as adjuvant chemotherapy for SCCHN. OBJECTIVES: There is no established consensus on the duration of administration of S-1 as adjuvant chemotherapy for squamous cell carcinoma of the head and neck (SCCHN). Since it might be difficult to undergo prospective randomized study to identify the optimal duration of the administration period of S-1 without a standard, the authors have undergone a retrospective clinical study to decide the tentative standard of therapeutic duration of S-1 as adjuvant chemotherapy for SCCHN. METHODS: The clinical records of 89 patients with SCCHN who underwent adjuvant chemotherapy with S-1 were investigated. RESULTS: The median duration of S-1 administration as adjuvant chemotherapy for SCCHN was 7 months (range = 0.1-58 months). Disease-free survivals (DFSs) were generally longer when S-1 administration periods were longer. After adjusting for prognostic factors, S-1 administration periods of 24 months or longer showed significantly lower hazard ratios (HRs) than 0-12 months.

DOI： 10.3109/00016489.2015.1049664

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：JAPANESE SOCIETY ALLERGOLOGY  

BACKGROUND: In contrast to Staphylococcus aureus-derived superantigenic exotoxins, the role of non-superantigenic exotoxins in the pathogenesis of eosinophilic airway diseases remains obscure. We sought to characterize S. aureus alpha-toxin-induced cellular responses in chronic rhinosinusitis with nasal polyps (CRSwNP). METHODS: Dispersed nasal polyp cells and uncinate tissue cells were prepared from patients with CRS with and without nasal polyps, respectively. Cells were incubated with various concentrations of alpha-toxin or staphylococcal enterotoxin B and then the levels of IL-5, IL-13, IFN-γ, IL-17A, and IL-10 in the cell supernatants were determined. The pathophysiological significance of alpha-toxin-induced cytokine production was also determined including radiological severity of rhinosinusitis, tissue and blood eosinophilia, serum total IgE level, and 1-s forced expiratory volume/forced vital capacity ratio (FEV1/FVC). RESULTS: Nasal polyp cells produced substantial amounts of IL-5, IL-13, IFN-γ, IL-17A, and IL-10 in response to alpha-toxin. Cytokine production was higher in nasal polyp cells than in uncinate tissue cells. The potency of alpha-toxin in stimulating IL-5, IL-13, and IL-10 production was comparable to that of enterotoxin. Alpha-toxin-induced IFN-γ, IL-17A, and IL-10 production significantly and negatively correlated with the degree of eosinophil infiltration into nasal polyps. Conversely, alpha-toxin-induced IFN-γ and IL-10 production significantly and positively correlated with FEV1/FVC. IL-10 production was significantly lower in asthmatic patients compared to non-asthmatics CONCLUSIONS: S. aureus-derived alpha-toxin can provoke cellular responses in nasal polyps. These responses, especially failure to synthesize IL-10, may play a role in the pathophysiology of CRSwNP.

DOI： 10.2332/allergolint.14-OA-0703

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：OCEAN SIDE PUBLICATIONS INC  

Interleukin (IL)-17A is a major cytokine produced by Th17 cells, which are associated with chronic inflammations. The local expression of IL-17A in allergic rhinitis (AR) remains to be characterized. We sought to determine the role of IL-17A expression in human inferior turbinate mucosa in the pathophysiology of AR. Inferior turbinate mucosa was sampled from medical treatment-resistant, surgery-required patients with perennial AR (PAR, n = 21), nonallergic rhinitis with eosinophilia syndrome (NARES, n = 7), and nonallergic hypertrophic rhinitis (HR, n = 13). IL-17A expression was determined with immunohistochemical staining. The mean number of IL-17A(+) cells and eosinophils per field were counted. Total serum immunoglobulin E (IgE) levels, blood eosinophil count, and forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) ratio were also examined in each patient. IL-17A was primarily expressed in infiltrating inflammatory cells. The number of IL-17A(+) cells in nasal mucosa was significantly higher in the PAR group compared with HR (p = 0.002) and NARES (p = 0.021) groups. There was a significant and positive correlation between the number of IL-17A(+) cells and total nasal symptom score (rho = 0.403; p = 0.011), especially sneezing score (rho = 0.471; p = 0.003). The number of IL-17A(+) cells was significantly and positively correlated with the degree of eosinophil infiltration (rho = 0.623; p < 0.001), but not with total serum IgE levels (rho = 0.284; p = 0.098), blood eosinophil counts (rho = 0.302; p = 0.056), or FEV1/FVC ratio (rho = 0.092; p = 0.569). The present study provides evidence that IL-17A expression in the nasal mucosa is associated with the pathophysiology of AR, including disease severity and nasal eosinophilia.

DOI： 10.2500/ar.2014.5.0078

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Background: A close relationship between upper and lower respiratory tract diseases has been reported. However, little is known about pulmonary function in patients with upper respiratory tract diseases. Methods: Pulmonary function was measured in: 68 patients with chronic rhinosinusitis without nasal polyps, 135 patients with chronic rhinosinusitis with nasal polyps, 89 patients with allergic rhinitis and 100 normal control subjects. The relationships between pulmonary function and clinical parameters were assessed. These parameters included radiographic severity of chronic rhinosinusitis, serum total immunoglobulin E levels, concentrations of cytokines in nasal secretions and exhaled nitric oxide levels. Results: The pulmonary function of patients with chronic rhinosinusitis was significantly affected. The level of interleukin-5 in nasal secretions was significantly correlated with pulmonary function in patients with chronic rhinosinusitis. Conclusion: The findings indicated latent obstructive lung function changes in chronic rhinosinusitis patients. The cytokines in nasal secretions might be related to obstructive lung function changes in chronic rhinosinusitis.

DOI： 10.1017/S0022215114000450

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY  

OBJECTIVES/HYPOTHESIS: Granulocyte/macrophage colony-stimulating factor is important in the pathogenesis of acute and chronic inflammatory disease. We hypothesized that granulocyte/macrophage colony-stimulating factor plays a pivotal role in middle ear inflammation and that neutralization of granulocyte/macrophage colony-stimulating factor would inhibit neutrophil migration into the middle ear and production of inflammatory mediators. STUDY DESIGN: Animal experiment. METHODS: We used transtympanic administration of lipopolysaccharide, a major component of gram-negative bacteria, into mice to induce an experimental otitis media. Control mice received injection of phosphate-buffered saline into the middle ear cavity. Mice were systemically treated with granulocyte/macrophage colony-stimulating factor neutralizing antibody or control immunoglobulin G via intraperitoneal injection 2 hours before transtympanic injection of lipopolysaccharide or phosphate-buffered saline. Middle ear effusions were collected. Concentrations of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, keratinocyte chemoattractant, and macrophage inflammatory protein-2 in middle ear effusions were measured by enzyme-linked immunosorbent assay. Histologic examination of the middle ear was also performed. RESULTS: Transtympanic injection of lipopolysaccharide upregulated levels of granulocyte/macrophage colony-stimulating factor, IL-1β, TNF-α, keratinocyte chemoattractant, and macrophage inflammatory protein-2 in the middle ear. Concentrations of cytokines and chemokines were significantly decreased in mice injected with granulocyte/macrophage colony-stimulating factor neutralizing antibody. Infiltration of inflammatory cells into the middle ear cavity induced by lipopolysaccharide was also significantly reduced by neutralization of granulocyte/macrophage colony-stimulating factor. CONCLUSIONS: Systemic injection of granulocyte/macrophage colony-stimulating factor neutralizing antibody inhibits the middle ear inflammation induced by lipopolysaccharide in mice. Our findings suggest that granulocyte/macrophage colony-stimulating factor may offer a novel therapeutic target for the management of intractable otitis media.

DOI： 10.1002/lary.23795

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：KARGER  

BACKGROUND: Interleukin-18 (IL-18) is a member of the IL-1 cytokine family that affects chronic inflammation. We sought to characterize IL-18 expression and investigate its release during chronic rhinosinusitis (CRS). METHODS: The expression of IL-18 in nasal polyps (NPs) and uncinate tissues (UTs) from both CRS and non-CRS patients was examined via immunohistochemistry. After culturing dispersed NP cells (DNPCs) with or without various stimulations, IL-18 levels were measured in the culture supernatants. Furthermore, the effect of IL-18 neutralization on staphylococcus enterotoxin B (SEB)-induced cytokine production was also examined. RESULTS: Similar expression of IL-18 in the epithelial layers was observed between the NPs and UTs. However, there was a significantly higher number of IL-18(+) cells in the lamina propria from NPs compared to UTs without CRS. This increased number was significantly correlated with the radiological severity of sinusitis and local eosinophilia. After the dispersion, IL-18 was spontaneously released by NP cells in a phase-dependent manner. While SEB, fungal antigens, and TLR agonists did not enhance the release, exposure to protease or one cycle of a freeze-and-thaw treatment did induce release of IL-18 from rested DNPCs. In addition, neutralization of IL-18 significantly suppressed SEB-induced IL-5, IL-13, and IFN-γ, but not IL-17A production. CONCLUSIONS: These results suggest that the pro-inflammatory effect of IL-18 released by danger signals may be involved in the pathogenesis of CRS, which includes eosinophilic inflammation and NP formation, via the augmentation of both Th2- and Th1-associated cytokine production.

DOI： 10.1159/000341668

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE INC  

BACKGROUND: The usefulness of early interventional treatment (EIT) with intranasal corticosteroids (INSs) compared with postonset treatment (POT) has not been clarified. OBJECTIVES: To study the efficacy and safety of EIT with INSs compared with POT and placebo in Japanese cedar/cypress pollinosis. METHODS: We designed a 3-armed, double-blinded, randomized, placebo-controlled trial. Patients received mometasone furoate nasal spray (EIT group: n = 25), placebo (n = 25), or 4 weeks of placebo followed by 8 weeks of mometasone (POT group: n = 25) for a 12-week period starting on February 1, 2011. The primary end point was the comparison of the total nasal symptom score (TNSS) among the 3 groups. Total ocular symptom score (TOSS), total naso-ocular symptom score (TSS), Allergic Rhinitis and Its Impact (ARIA) on Asthma classification, and safety were the main secondary end points. RESULTS: The placebo and POT groups, but not the EIT group, had a significant exacerbation of TNSS and TOSS soon after the start of pollen counts being high on consecutive days. The 12-week mean TSS in the EIT group (score, 2.3) was significantly lower than in the placebo (5.0; P < .01) and POT (3.9; P = .03) groups. All patients in the placebo and POT groups were classified as having persistent rhinitis, whereas 80% of the EIT group met the ARIA classification criteria (P = .03). The quality-of-life score and nasal eosinophil cationic protein levels were lower in the EIT and POT groups compared with the placebo group. Daytime sleepiness, smell disturbance, and the mean dose of loratadine taken as the rescue medication were similar. Treatment with mometasone was well tolerated. CONCLUSION: EIT with INSs is superior to POT in controlling pollinosis.

DOI： 10.1016/j.anai.2012.08.016

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY-BLACKWELL  

OBJECTIVES/HYPOTHESIS: Immunoglobulin G4 (IgG4)-related sclerosing sialadenitis is a recently recognized disease entity characterized by high serum IgG4 concentration and IgG4-producing plasma cell expansion in affected organs, which show fibrotic or sclerotic changes. However, little is known about the roles of CD4+ and CD8+ T cells or interleukin (IL)-17 in this disease. The purpose of this study was to evaluate the characteristics of CD4+ and CD8+ T cells and IL-17 in patients with IgG4-related sclerosing sialadenitis. STUDY DESIGN: A retrospective clinical study at the Yamagata University School of Medicine. METHODS: The patient group consisted of six males and four females with an average age of 57.9 years (range, 38 to 73 years). Subsets of T helper (Th)1, Th2, T cytotoxic type (Tc)1, and Tc2 cells from patients with IgG4-related sclerosing sialadenitis were examined by using intracellular cytokine flow cytometry. Expression of IL-17 in the patients' lesions was also investigated immunohistochemically. RESULTS: Six patients with IgG4-related sclerosing sialadenitis with high ratios of IgG4/IgG and prominent infiltration of IgG4-positive plasmacytes in the involved salivary glands had systemic complications, including pancreatitis, retroperitoneal fibrosis, and/or inflammatory pseudotumor of the lung after the initial swelling of the salivary glands. Populations of Th1 and Tc1 cells were significantly greater in IgG4-related sclerosing sialadenitis than in the controls (P < .05), but Th2 and Tc2 cell populations were not significantly increased. Expression of IL-17 was observed in the lesions of affected patients. CONCLUSIONS: Increases in Th1 and Tc1 cell populations and IL-17 expression might be involved in the mechanism of pathogenesis of IgG4-related sclerosing sialadenitis.

DOI： 10.1002/lary.23429

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Background: Lipopolysaccharide (LPS) has shown heterogeneous effects on eosinophilic inflammation in airways. However, little is known about how LPS regulates pathogenesis of chronic rhinosinusitis with nasal polyps, a major form of eosinophilic inflammation in the upper airway. Objective: We sought to investigate the effect of LPS on cytokine production by dispersed nasal polyp cells (DNPCs). Methods: Either diclofenac-treated or untreated DNPCs were cultured with or without staphylococcal enterotoxin B (SEB) in the presence or absence of LPS, after which the levels of IL-5, IL-13, IL-17A and IFN-γ within the supernatant were measured. The effects of PGE2 on LPS-induced responses by diclofenac-treated DNPCs were also examined. LPS-induced PGE2 production and mRNA expression of COX-1, COX-2 and microsomal PGE2 synthase-1 (m-PGES-1) were measured. Results: Staphylococcal enterotoxin B induced IL-5, IL-13, IL-17A and IFN-γ production by DNPCs. Pre-treatment with LPS prior to SEB stimulation inhibited production of these cytokines. After stimulation with LPS, PGE2 production and expression of COX-2 and m-PGES-1 mRNA by DNPCs increased significantly. In the presence of diclofenac, the suppressive effects of LPS were eliminated. LPS pre-treatment enhanced SEB-induced IL-5, IL-13 and IL-17A production in diclofenac-treated DNPCs, while addition of PGE2 inhibited IL-5, IL-13 and IFN-γ production. LPS alone induced IL-5, IL-13 and IFN- γ production by diclofenac-treated DNPCs, while the addition of EP2 and EP4 receptor-selective agonists, as well as PGE2 itself, inhibited IL-5 and IL-13 production. Conclusions and Clinical Relevance: These results suggest that the regulatory effects of LPS on eosinophilic airway inflammation are controlled via the COX-2/PGE2 axis. For clinical implications, indiscreet use of non-steroidal anti-inflammatory drugs should be avoided in patients with chronic rhinosinusitis with nasal polyps. © 2012 Blackwell Publishing Ltd.

DOI： 10.1111/j.1365-2222.2012.04015.x

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：JAPANESE SOCIETY ALLERGOLOGY  

BACKGROUND: Little is known about the safety and effectiveness of early interventional treatment (EIT) with intranasal corticosteroids for seasonal allergic rhinitis. We designed a double-blinded, randomized, placebo-controlled 12-week trial of EIT with mometasone furoate nasal spray (MFNS) for Japanese cedar/cypress pollinosis (JCCP). METHODS: A total of 50 JCCP patients received MFNS (200μg once daily: n = 25) or placebo (n = 25) starting on February 1, 2010. Treatments continued until the end of April. The primary endpoint was the comparison of the total nasal symptom score (TNSS) between the MFNS and placebo groups. The secondary endpoints included comparisons of QOL, daytime sleepiness, nasal ECP levels, and safety. RESULTS: Continuous dispersion of Japanese cedar pollen began on February 22. Although the placebo group showed a significant worsening of symptoms after the start of the continuous dispersion, no worsening occurred in the MFNS group. A significant difference in the TNSS between the two groups was seen starting at 4 weeks after the treatment. Similar results were seen for QOL and sleepiness. Nasal ECP levels in March were significantly lower in the MFNS group. A total of 56% of the MFNS group progressed to a persistent allergic rhinitis state in accordance with the ARIA classification, as opposed to 84% of the placebo group. MFNS was well tolerated, and the plasma cortisol concentrations were similar between the two groups. CONCLUSIONS: EIT with MFNS for JCCP is both safe and effective. This treatment can potentially lessen symptoms and help pollinosis patients remain in the intermittent state.

DOI： 10.2332/allergolint.11-OA-0382

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Summary: Background Fungi and/or Staphylococcus aureus enterotoxins (SEs) may participate in the pathogenesis of eosinophilic inflammation in cases of chronic rhinosinusitis with nasal polyps (CRSwNP).Objective We sought to determine the effects of fungal antigens on eosinophilia-associated cellular responses in nasal polyps.Methods Dispersed nasal polyp cells (DNPCs) were prepared from 13 patients with CRSwNP. DNPCs were cultured with fungal extracts (Aspergillus, Alternaria and Candida) or SEB for 72 h, after which the levels of IL-5, IL-13 and RANTES were measured within the supernatant. Responses to β-d-glucan, mannan and chitin were also examined.Results 38.5%, 69.2% and 30.8% of DNPCs produced IL-5, IL-13 and RANTES, respectively, in response to 200 μg/mL of Aspergillus. 53.8%, 53.8% and 7.7% of DNPCs produced IL-5, IL-13 and RANTES, respectively, in response to 200 μg/mL of Alternaria. 53.8%, 38.5% and 15.4% of DNPCs produced IL-5, IL-13 and RANTES, respectively, in response to 200 μg/mL of Candida. All DNPCs produced these cytokines in response to 0.1 μg/mL of SEB. SEB induced significantly greater cytokine levels than the fungal extracts. No correlation between cytokine production following exposure to each of the fungal extracts or SEB and various clinical features, including nasal polyp eosinophilia and radiological severity of sinusitis was observed. Neither sensitization to fungus nor comorbidity with bronchial asthma was correlated with the fungal extract-induced cytokine production by DNPCs. β-d-glucan, mannan and chitin did not induce significant cytokine production.Conclusions These results suggest that, although DNPCs produce IL-5, IL-13 and RANTES in response to fungal extracts, fungal antigens including major carbohydrates are less capable of inducing eosinophilia-associated cellular responses in nasal polyps than SEB. © 2011 Blackwell Publishing Ltd.

DOI： 10.1111/j.1365-2222.2010.03584.x

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Otitis media is one of the most common and intractable ear diseases, and is the major cause of hearing loss, especially in children. Multiple factors affect the onset or development of otitis media. Prostaglandin D2 is the major prostanoid involved in infection and allergy. However, the role of prostaglandin D2 and prostaglandin D2 receptors on the pathogenesis of otitis media remains to be determined. Recent studies show that D prostanoid receptor (DP) and chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) are major prostaglandin D2 receptors. In this study, homozygous DP single gene-deficient (DP-/-) mice, CRTH2 single gene-deficient (CRTH2-/-) mice and DP/CRTH2 double gene-deficient (DP-/- CRTH2-/-) mice were used to investigate the role of prostaglandin D2 and its receptors in otitis media. We demonstrate that prostaglandin D2 is induced by lipopolysaccharide (LPS), a major component of Gram-negative bacteria, and that transtympanic injection of prostaglandin D2 up-regulates macrophage inflammatory protein 2 (MIP-2), interleukin (IL)-1β and IL-6 in the middle ear. We also show that middle ear inflammatory reactions, including infiltration of inflammatory cells and expression of MIP-2, IL-1β and IL-6 induced by LPS, are reduced significantly in DP-/- mice and DP-/- CRTH2-/- mice. CRTH2-/- mice display inflammatory reactions similar to wild-type mice. These findings indicate that prostaglandin D2 may play significant roles in LPS-induced experimental otitis media via DP. © 2010 The Authors. Clinical and Experimental Immunology © 2010 British Society for Immunology.

DOI： 10.1111/j.1365-2249.2010.04292.x

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：MOSBY-ELSEVIER  

DOI： 10.1016/j.jaci.2010.09.029

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DOI： 10.1016/j.jaci.2010.05.014

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：MOSBY-ELSEVIER  

BACKGROUND: Recent investigations have revealed that staphylococcal enterotoxins (SEs), COX metabolism, or both might participate in the pathogenesis of eosinophilic airway diseases, such as chronic rhinosinusitis with nasal polyposis. OBJECTIVE: We sought to determine whether COX metabolism, especially prostaglandin (PG) E(2), plays a significant role in SE-induced cellular responses in nasal polyps. METHODS: Dispersed nasal polyp cells (DNPCs) were prepared from nasal polyps by means of enzymatic digestion. DNPCs were cultured with SEB in the presence or absence of COX inhibitors (diclofenac and indomethacin) for 72 hours; then the levels of IL-5, IL-13, RANTES, and eotaxin in the supernatants were measured. The effect of PGE(2) on SEB-induced responses by diclofenac-treated DNPCs was examined, especially in terms of receptor specificity. RESULTS: DNPCs produced significant amounts of IL-5, IL-13, and RANTES in response to SEB. COX inhibitors significantly increased the production of these cytokines. The degree of local eosinophilia was significantly and positively correlated with the changes in IL-5 production induced by diclofenac treatment. PGE(2) significantly and dose-dependently inhibited SEB-induced IL-5, IL-13, and RANTES production by diclofenac-treated DNPCs. E-prostanoid (EP) 2 receptor-selective agonist strongly inhibited the production of all 3 cytokines. EP3 and EP4 receptor-selective agonists partially suppressed these responses, whereas EP1 receptor-selective agonist did not. Interestingly, all of the combined treatments with 2 of the 4 EP receptor-selective agonists significantly inhibited the SEB-induced responses by diclofenac-treated DNPCs. CONCLUSIONS: These results suggest that PGE(2) inhibits the pathogenesis of SEB-induced eosinophilic inflammation primarily through the EP2-mediated pathway in patients with chronic rhinosinusitis with nasal polyposis.

DOI： 10.1016/j.jaci.2009.01.047

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japan Society of Stomato-pharyngology  

Renal metastasis originating from metachronous development of hypopharyngeal and esophageal cancer is reported. A 60-year-old man had received pharyngolaryngectomy for hypopharyngeal cancer in 2003. He had stomachache in 2005 and a right renal tumor was found with CT and MRI. Percutaneous needle biopsy was performed and histological results showed squamous cell carcinoma. At the same time, squamous cell carcinoma was detected in the esophagus. He had chemotherapy but it was ineffective. This case was thought to be a rare case of metastatic renal cancer arising from multiple primary cancers.

DOI： 10.14821/stomatopharyngology1989.20.293

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Other Link： http://search.jamas.or.jp/link/ui/2008358660

Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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Language：Japanese   Publisher：(株)医学書院  

＜文献概要＞POINT ▼内反性乳頭腫の基部推定には,骨肥厚像,もしくは骨融解像が重要である。▼血管線維腫は蝶口蓋孔を中心に周囲に広がる腫瘤で,造影CTで強く濃染される。▼上顎がんは隣接する副鼻腔の骨破壊を生じ,壊死部位により内部不均一となる。▼頭蓋底に発生した髄膜脳瘤は,頭蓋底の骨欠損を介し,頭蓋内からの脳組織の脱出,脳溝の連続を認める。

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Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2022&ichushi_jid=J02122&link_issn=&doc_id=20220405090009&doc_link_id=10.11477%2Fmf.1411202961&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1411202961&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：(NPO)日本頭頸部外科学会  

巨大な鼻腔血管腫の手術では良好な視野の確保が困難となることが多く,また術中に大量出血をきたすことがあるため,術式の選択が重要とされる。本症例は,78歳女性,左鼻腔を充満する血管腫症例である。術前塞栓術を試みたが施行できなかったため,手術の最初に栄養血管である蝶口蓋動脈の処理が必要であった。TACMI法とEndoscopic Denker's Approachを併用することで,蝶口蓋動脈凝固切断後の腫瘍の一塊切除が,内視鏡下に可能となった。これらの術式の併用は,巨大な鼻腔腫瘍,特に蝶口蓋動脈の処理も必要な場面において有用であると考えられた。(著者抄録)

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Language：Japanese   Publisher：(一社)日本鼻科学会  

若年性血管線維腫は思春期男性に好発する易出血性の血管性腫瘍で,局所浸潤性が高く,鼻腔内から翼口蓋窩を中心に周囲組織を破壊進展する。手術療法は,様々な外切開が適応とされることが多かったが,近年では手術器具,技術,ナビゲーションシステムなどの進歩により経鼻内視鏡下に摘出される報告が増えている。Endoscopic tri-port approach法とは,Omuraらの提唱したTransseptal access with crossing multiple incisions(TACMI法),Direct approach to the anterior and lateral part of the maxillary sinus with an endoscope(DALMA法)と,Weberらの提唱した鼻涙管切断を伴う下鼻甲介処置を組み合わせることで,両外鼻孔からの経鼻中隔,経鼻腔,経上顎洞前壁の3つのポートを使用して,0度の内視鏡で翼口蓋窩や眼窩などへアプローチする方法である。今回我々は17歳の男性で,鼻腔,上咽頭から翼口蓋窩に一部進展の認める若年性血管線維腫,Radkowski分類Stage IIA期に対して,術前日に選択的血管塞栓術を施行した後に,Endoscopic tri-port approach法にて一塊切除した。Endoscopic tri-port approach法は顔面の外切開や歯齦部切開を施行することなく,可能な限り鼻中隔や下鼻甲介を温存しながら,広い術野で病変部への到達が可能であり,翼口蓋窩進展を認める若年性血管線維腫に対して有用なアプローチ法と考えられた。(著者抄録)

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Language：Japanese   Publisher：(株)医学書院  

＜文献概要＞Point ▼鼻副鼻腔内からの出血に対する止血方法の基本は,出血点を同定して凝固焼灼止血を行うことである。▼止血資材には,外来での鼻出血に対する処置などに使用される酸化セルロースやゼラチンスポンジ,主に頭蓋底手術に使用されるゼラチン・ヒトトロンビン合材など,状況に応じた選択肢がある。▼内視鏡下鼻内副鼻腔手術(ESS)終了後のパッキング資材として,圧迫による癒着予防効果をもち,吸引除去が可能なナゾポアが有用である。

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：English  

DOI： 10.1111/all.14858

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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Language：Japanese   Publisher：(一社)日本鼻科学会  

鼻腔粘膜悪性黒色腫に関しては手術が可能な場合は手術が第一選択とされており,近年では内視鏡手術が選択される事が多くなってきている。今回,経鼻内視鏡手術で摘出したskip病変を伴う鼻腔粘膜悪性黒色腫の1例を経験したため報告する。症例は86歳男性。鼻腔腫瘍からの反復性鼻出血のため当科紹介された。腫瘍生検で鼻腔粘膜悪性黒色腫の診断となり全身麻酔下で経鼻内視鏡手術を行った。術後の鼻腔内視鏡検査で右上顎洞にskip病変を認めた。初回手術2ヵ月後に根治目的でendoscopic medial maxillectomy(EMM)を行ったところ,術前に指摘できなかったskip病変が右下鼻道にも認められた。現在,再手術後3年半経過しているが再発や転移を認めていない。(著者抄録)

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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Language：Japanese   Publisher：香川労災病院  

症例1は54歳男性で、数ヵ月前からの視力低下を自覚して近医眼科を受診、両耳側半盲を指摘され、精査加療目的に当科紹介受診となった。非機能性下垂体腺腫と術前診断し、経鼻的内視鏡手術における下垂体腺腫摘出術の方針とした。術後軽度の頭痛は認めたものの両側の視力および視野は改善を認め、尿崩症等の内分泌異常、髄液漏等もなく第15病日に退院となった。病理結果は下垂体腺腫であった。症例2は68歳男性で、1年前から嗅覚障害を自覚しており、近医耳鼻科を受診、嗅覚低下・嗅裂ポリープを認め当院耳鼻咽喉科に紹介受診となった。鼻腔内所見における嗅裂ポリープの生検にて嗅神経芽細胞腫と診断された。鼻腔経由での血管処理が困難と考え、左上眼瞼皮膚切開を併用し、前篩骨動脈、後篩骨動脈の凝固切断、経鼻内視鏡下に鼻副鼻腔腫瘍、頭蓋底骨、硬膜両嗅球、両嗅索を一塊切除した。術後経過は良好で第12病日に退院となった。

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

【背景】わが国における昆虫アレルゲン感作の実態や,その特徴については未明な点が多い。【対象と方法】鼻症状を主訴に国際医療福祉大学三田病院(東京都)あるいは国際医療福祉大学病院(栃木県)を受診し,特異的IgE検査を施行した524症例(東京都316例,栃木県208例)を対象とした。2病院における昆虫(蛾,ユスリカ,ゴキブリ)感作率と,昆虫感作例,特に昆虫単独感作例の臨床免疫学的特徴を検討した。【結果】蛾,ユスリカ,ゴキブリの感作率は東京で30.7%,10.0%,10.6%,栃木で26.4%,10.6%,12.5%であり,東京と栃木で有意差を認めなかった。昆虫感作例の中,95.1%が蛾への感作を示した。昆虫非感作例と比較して昆虫感作例は,有意差をもって男性に多く血清総IgE値が高かった。昆虫単独感作例は他抗原との重複感作例と比較し,高齢者に有意に多く認めた。また有意な差を認めなかったものの,重複感作例と比較し昆虫単独感作例で通年性の症状を多く認めた。【まとめ】アレルギー性鼻炎の昆虫抗原として蛾の重要性が確認された。昆虫抗原への感作率は都市部と郊外で差を認めなかった。昆虫単独感作例は高齢男性が多い,総IgE値が高い,通年性症状という特徴を示した。特に高齢者では血管運動性鼻炎や老人性鼻漏の患者層と重なっており,総IgE値が高い症例では昆虫抗原を含めたIgE検査を行う必要が示唆された。(著者抄録)

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Language：Japanese   Publisher：(株)医学書院  

28歳男。出生時から顔貌異常があり、過成長を認めた。10代の頃にソトス症候群と臨床診断されていたが、全身状態が落ち着いていたため定期通院はしていなかった。今回、日中の眠気・頭痛があり、睡眠時無呼吸症候群の精査目的で当科を受診した。諸検査の結果から、下顎低形成による硬組織の異常から口腔・咽頭腔の狭小化をきたし、閉塞性睡眠時無呼吸症候群になっていると考えた。持続陽圧呼吸(CPAP)療法を行い、治療効果判定のためCPAP装着下にポリソムノグラフィ検査を行ったところ、AHI、AIとも改善していることが確認された。日中の眠気・頭痛も改善し、現在CPAPを継続しながらフォロー中である。

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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Language：Japanese   Publisher：(NPO)日本頭頸部外科学会  

本症例は18歳の男性で、鼻ほじりが原因と考えられる13mm大の鼻中隔穿孔を認め、Unilateral mucosal advancement flap techniqueを使用して穿孔閉鎖施行した。術後は穿孔が閉鎖し、自覚症状が消失した。Unilateral mucosal advancement flap techniqueは片側鼻腔で穿孔の下方と上方に二つのflapを作成し、そのflap同士を縫合することで穿孔を閉鎖する方法である。Flapは双茎で血流もよく、Interposition graftと組み合わせることで、1cmを超える中等度の大きさの鼻中隔穿孔の閉鎖に有効な方法と考えられた。(著者抄録)

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Language：Japanese   Publisher：(NPO)日本頭頸部外科学会  

嗅神経芽細胞腫は、近年経鼻内視鏡下摘出術が導入されているが、腫瘍切除方法については、頭蓋底骨、硬膜、嗅球、嗅索と鼻腔内腫瘍を一塊切除するか、multi-layer resectionを施行するかに関して議論がある。本症例は70歳男性、硬膜浸潤を認めるKadsish分類Stage Cで眼窩内側壁に接する嗅神経芽細胞腫症例である。腫瘍近接のため経鼻的に篩骨動脈の確保が困難と考え、上眼瞼皮膚切開による内視鏡下経眼窩アプローチでの前、後篩骨動脈の凝固切断を施行し、経鼻内視鏡下に腫瘍を一塊切除施行した。副鼻腔内が腫瘍で充満しており、経鼻的に篩骨動脈へのアプローチが困難な場合に、有用であると考えられた。(著者抄録)

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

内視鏡経鼻頭蓋底手術は広く行われるようになったが、手術侵襲の程度によっては時に硬膜再建が必要になることがある。今回、硬膜補綴材であるポリグリコール酸(PGA)フェルトを使用し硬膜再建を行った2症例を報告する。症例1は78歳男性。嗅神経芽細胞腫(Kadish分類Stage B)の腫瘍切除後に硬膜欠損に対してPGAフェルト・鼻中隔粘膜弁を用いて硬膜再建した。症例2は68歳女性。外反性乳頭腫に合併した扁平上皮癌であり、術中に篩板からの髄液漏を認めPGAフェルト・有茎粘膜弁を用いて硬膜再建した。術後に感染や髄液漏はなく、PGAフェルトを用いることで簡便かつ短時間で低侵襲に硬膜再建を行うことができた。(著者抄録)

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Language：Japanese   Publisher：(株)医学書院  

症例1は40歳男性で、反復性の左鼻出血と鼻の痛みを主訴とした。CTで左上顎洞から一部の前篩骨洞にかけて内部不均一で造影効果の乏しい腫瘤性病変を認めた。上顎洞血瘤腫を疑い、endoscopic modified medial maxillectomy(EMMM)を施行した。症例2は80歳女性で、反復性の左鼻出血を主訴とした。CTで左上顎洞に充満する陰影を認め、脳血管造影で明らかな栄養血管や腫瘍濃染を認めなかった。上顎洞血瘤腫を疑い、EMMMを施行した。症例3は73歳男性で、頭痛を主訴とした。CTで左蝶形骨洞に充満する陰影を認め、脳血管造影で明らかな栄養血管や腫瘍濃染を認めなかった。蝶形骨洞血瘤腫を疑い、拡大蝶形骨洞手術を施行した。手術は正円孔、翼突管を同定し、広く蝶形骨洞前壁を開放した術野で行った。3例とも病理診断は血瘤腫で、症例1は術後約5年、症例2は術後約8ヵ月、症例3は術後2年5ヵ月の現在まで再発を認めていない。

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Language：Japanese   Publisher：(株)医学書院  

症例1は70歳男性で、右顔面神経麻痺と右耳痛を主訴とした。外耳道内に肉芽形成を認め、CTで右鼓室と乳突洞の軟部組織陰影、外耳道骨部から鼓室、乳突洞にかけての骨破壊像を認めた。細菌検査で右耳漏からアスペルギルスが検出された。顔面神経麻痺を伴った右悪性外耳道炎と診断し、シタフロキサシンの内服と高気圧酸素療法を行った。また、外耳道内にビホナゾールの塗布とブロー液による処置を行った。症例2は71歳男性で、両耳漏と両耳痛を主訴とした。外耳道内に肉芽形成を認め、CTで両側外耳道骨部から鼓室、乳突洞、両側下顎頭にかけて骨破壊像を認めた。細菌検査で耳漏からニューキノロン耐性緑膿菌を検出した。両側悪性外耳道炎と診断し、タゾバクタム/ピペラシリンの点滴と高気圧酸素療法を行った。2例とも経過は良好であったが、症例2は治療開始後25ヵ月に既往の悪性リンパ腫が再発し死亡した。

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Language：Japanese   Publisher：(一社)日本アレルギー学会  

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Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J00009&link_issn=&doc_id=20190208340007&doc_link_id=1390845713054037760&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390845713054037760&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_3.gif

Language：Japanese   Publisher：(株)東京医学社  

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：(株)東京医学社  

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Language：Japanese   Publisher：(一社)日本鼻科学会  

線維性骨異形成症は非腫瘍性の線維性骨病変であり、頭蓋顔面領域に発生することが多い。今回、蝶形骨洞線維性骨異形成症に対して内視鏡手術で摘出した症例を経験したので報告する。症例は26歳男性。前医で頭痛の精査のためCTを撮影したところ蝶形骨洞に陰影が認められ当科紹介となった。初回の内視鏡下生検手術時の病理組織検査は化骨性線維腫の疑いという診断であった。その後、経鼻内視鏡下に腫瘤摘出術を行い、最終的には線維性骨異形成症の診断となった。術後1年半経過しているが再発はなく無症状で経過観察中である。(著者抄録)

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Language：Japanese   Publisher：(一社)日本鼻科学会  

髄膜脳瘤は頭蓋骨の欠損孔から頭蓋内容が頭蓋外に脱出する疾患である。先天性の骨欠損による髄膜脳瘤は後頭部に多く発生し、頭蓋底に発生することは稀である。今回、前頭洞後壁の骨欠損部から鼻腔へと脱出した前頭洞型頭蓋底髄膜脳瘤症例に対して、前頭開頭術と経鼻内視鏡下鼻副鼻腔手術を併用した切除術を施行し、良好な経過を得たので報告する。症例は40歳、男性。感冒薬を内服後に意識障害を認め、近医総合病院へ救急搬送された。横紋筋融解症を認め、透析などの加療が施行された。また、頭部MRIで左篩骨洞・前頭洞陰影と脳室拡大を認めた。髄液鼻漏所見を認めたため同院耳鼻咽喉科へ紹介され、左鼻腔内腫瘤の生検を行ったところ脳組織とのことであった。横紋筋融解症が改善したのちも意識障害が遷延するため、精査加療目的で当院脳神経外科へ転院となった。意識障害はフェノバルビタールナトリウムなどの点滴静注治療により軽快した。髄膜脳瘤に対して前頭開頭術と内視鏡下鼻副鼻腔手術を併用した切除手術と前頭蓋底再建術を施行した。術後2年を経過して髄膜脳瘤の再発は認められない。近年、頭蓋底髄膜脳瘤に対しては内視鏡による経鼻的アプローチのみで切除術を行う報告が増加している。本症例は前頭洞後壁に骨欠損部があり、内視鏡下操作のみでは硬膜再建が困難と判断した。髄膜脳瘤は比較的まれな疾患であり、症例によって適切なアプローチ法を検討することが必要と思われた。(著者抄録)

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Language：Japanese   Publisher：(一社)日本鼻科学会  

副鼻腔真菌症は一般には上顎洞へ片側に発症するとされており、前頭洞や両側に副鼻腔真菌症が発症することは極めて稀である。今回、前頭洞真菌症と対側の蝶形骨洞へ同時に発見された副鼻腔真菌症の1例を経験したため、文献的考察を加えて報告する。症例は71歳女性。頭痛により他院で頭部CTを撮影したところ前頭洞陰影を認めたため当科紹介された。CT上は左の前頭洞真菌症であり全身麻酔下にEndoscopic modified Lothrop procedureで真菌塊を摘出した。術後、CTで再評価したところ対側の右蝶形骨洞側窩のみに限局する陰影を認めた。初回CTを見直したところ蝶形骨洞には以前から陰影あり、蝶形骨洞真菌症に対して全身麻酔下で右蝶形骨洞開窓しハイドロデブリッダーシステムR(日本メドトロニック、東京)を用いて洗浄した。術後1年間経過したが真菌の再発を認めず、外来で経過観察中である。副鼻腔真菌症は複数洞や両側罹患の可能性もあるため、術前のCT読影を厳密にするべきと考えた。(著者抄録)

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Language：Japanese   Publisher：(一社)日本耳科学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：(NPO)日本気管食道科学会  

扁桃周囲膿瘍の治療として抗菌薬などによる保存的治療、穿刺もしくは切開排膿、全身麻酔下での即時膿瘍扁桃摘出術(膿瘍扁摘)がある。治療が有効でない場合には深頸部膿瘍や縦隔炎などで致死的となることがあり注意が必要である。今回、造影CT所見と治療法の選択、臨床経過について検討を行った。対象は2013年1月から2016年4月に当院を受診し、造影CTで扁桃周囲膿瘍を認めた100例とした。CT軸位断で膿瘍腔の最大径を計測し、計測部位が口蓋垂末端よりも頭側にあるものを上極型、尾側にあるものを下極型とし、膿瘍径、喉頭浮腫の有無、治療法、治療期間を検討した。上極型の方が膿瘍径は大きかったが、喉頭浮腫は下極型で多かった。保存的治療とした症例は全例膿瘍径16mm以下であり、膿瘍扁摘や穿刺・切開の症例と比較して小さかった。上極型では穿刺・切開で十分排膿可能であり、膿瘍扁摘により治療した症例と比較して治療期間が短く、最も多く選択された治療法であった。下極型では膿瘍扁摘と穿刺・切開で入院期間に差がなく、膿瘍径の大きな症例では確実な排膿が可能で再発防止になる膿瘍扁摘を選択した症例が多かった。(著者抄録)

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Language：Japanese   Publisher：(一社)日本アレルギー学会  

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Language：Japanese   Publisher：(株)医薬ジャーナル社  

鼻噴霧用ステロイド薬はアレルギー性鼻炎に対して強力な抗炎症作用を示す。花粉症の本格発症前の最小持続炎症の制御という観点から,これまで,鼻噴霧用ステロイド薬は花粉症初期治療薬としての有用性が議論されていたが,最新版の鼻アレルギー診療ガイドライン(2016年版)からは,鼻噴霧用ステロイド薬は初期療法の1つとして記載されるようになった。自験例も含めいくつかのプラセボ対照二重盲検比較試験において,鼻噴霧用ステロイド薬によるスギ・ヒノキ花粉症に対する初期治療は,プラセボと比較して症状およびQOLの増悪を有意に抑制した。一方,安全性に関しては実薬とプラセボとの間に有意な差を認めなかった。さらに発症後治療と比較しても花粉の本格飛散後の鼻眼症状の増悪を有意に抑制した。以上の結果からは鼻噴霧用ステロイド薬による初期治療は有効かつ安全な治療法であることが明らかとなった。しかし,初期治療の適切な開始時期や飛散花粉数による効果の変化など今後の検討も必要である。(著者抄録)

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Language：Japanese   Publisher：(一社)日本鼻科学会  

ビスフォスフォネート(Bisphosphonate:BP)製剤は癌の骨転移の治療や,骨粗鬆症の予防に対して広く使用されている。一方,2003年に米国で初めて報告されたビスフォスフォネート関連顎骨壊死(Bisphosphonate-Related Osteonecrosis of the Jaw:BRONJ)はわが国においても少なからぬ発生を認め,その予防法や対処法の確立は急務である。今回我々は,副鼻腔炎から眼窩骨膜下膿瘍を続発したBRONJ症例を経験したので報告する。症例は86歳,女性。1ヵ月前から続く右側上歯肉部からの膿汁排出を主訴に近医歯科を受診し,当院歯科口腔外科へ紹介となった。約10年前より骨粗鬆症に対してBP製剤であるアレンドロネートを,慢性関節リウマチに対してメチルプレドニゾロンやメトトレキサートを内服していた。CTにて右側副鼻腔陰影を認め,当科を紹介され慢性副鼻腔炎と診断した。歯科にてBRONJと診断され,アレンドロネート休薬から3ヵ月後に腐骨除去と右内視鏡下副鼻腔手術(以下ESS)を予定し,抗生剤での保存的加療を開始した。休薬から2.5ヵ月後に右眼瞼発赤が生じ,造影CTにて右眼窩骨膜下膿瘍の所見を認めた。同日,眼窩紙様板除去を含むESSと腐骨除去,周囲骨削除の緊急手術を施行した。術後,骨膜下膿瘍,骨壊死の再増悪もなく,経過良好である。BRONJ症例への腐骨除去など外科治療の際にはBP製剤の休薬が望まれるが,BRONJを伴う慢性副鼻腔炎に対しては,全身状態が許せば通常上顎骨に対して侵襲は少ないと考えられるESSを腐骨除去より先行させることも選択肢となりうる可能性が示唆された。(著者抄録)

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Language：Japanese   Publisher：(NPO)日本気管食道科学会  

頭頸部癌において放射線治療の適応は広がってきているが、重大な合併症の一つに喉頭壊死がある。今回、放射線治療後の喉頭壊死2症例を経験した。【症例1】67歳男性。喉頭癌T3N0M0に対してcetuximab併用放射線療法(70Gy)を施行。治療終了5ヵ月後に気道狭窄症状を認め緊急気管切開を行った。画像検査で再発、喉頭壊死の鑑別不能であり喉頭摘出を行った。病理検査では悪性所見を認めなかった。【症例2】79歳男性。盲腸癌、左頸部リンパ節転移に対して化学放射線治療(66Gy)を施行。3年8ヵ月後に左頸部リンパ節が再増大し、気道狭窄症状を認め緊急気管切開を行った。再発頸部リンパ節転移に対して追加照射(54Gy)を行い、治療終了1ヵ月後に嚥下困難、悪臭が出現した。喉頭壊死と診断し、総頸動脈浸潤が疑われたため手術は行わず、高圧酸素治療を行った。悪臭などの症状は一旦消失したものの、1ヵ月後に原病死した。喉頭の壊死、炎症と癌の残存、再発との鑑別は難しく、治療をかねて喉頭摘出術となるケースが多い。保存的治療として抗生剤、ステロイド、高圧酸素などがあり、全身状態や患者の喉頭温存希望が強い症例では治療選択肢となる。(著者抄録)

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Language：Japanese   Publisher：(株)医学書院  

鼻口蓋管嚢胞の根治的治療法として一般に嚢胞全摘出術が行われるが、嚢胞が巨大な場合には摘出後の死腔の処理が問題となる。今回著者等は、巨大な嚢胞に対して内視鏡下鼻内手術を行い、嚢胞を両側鼻腔に開窓し、良好な結果が得られたので報告した。症例は38歳男で、嚢胞の大きさは画像検査上57×56×48mmで、鼻腔底部と口蓋部に骨欠損があり、摘出術を施行した場合には鼻腔と口蓋の間に瘻孔を形成する可能性があった。また、手術で口腔内に開窓すると創が汚染され、鼻腔と口蓋の間に瘻孔を形成する可能性もあった。さらに、鼻腔底に嚢胞壁が大きく進展していたため、手術では、鼻腔粘膜よりも強固な口蓋粘膜を温存して嚢胞を鼻腔に開窓した。

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Language：Japanese   Publisher：耳鼻咽喉科臨床学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：(株)医学書院  

2012年1月から2015年6月までに保存的治療で十分な治療効果が得られず、内視鏡下副鼻腔手術(ESS)を行った好酸球性副鼻腔炎(ECRS)45症例を対象として、術前後の自覚症状、quality of life(QOL)の変化と内視鏡所見の変化について検討した。術前、術後3ヵ月前後、6ヵ月前後の時点での鼻症状アンケートで自覚症状、QOLに関する質問を評価するとともに、鼻内ポリープスコアを用いて内視鏡評価を比較した結果、自覚症状スコア、QOLスコアの両方において、術後3ヵ月、6ヵ月ともに嗅覚低下、鼻閉やTotal Nasal Symptom Scoreなど多くの項目で有意な改善を認め、概ね良好な術後経過をたどった。

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Language：Japanese   Publisher：(NPO)日本気管食道科学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科学会  

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Language：Japanese   Publisher：日本鼻科学会  

DOI： 10.7248/jjrhi.55.99

CiNii Article

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：(株)全日本病院出版会  

鼻噴霧用ステロイド薬はアレルギー性鼻炎に対して強力な抗炎症作用を示すことが知られている。鼻アレルギー診療ガイドラインでは、花粉症に対して、鼻噴霧用ステロイド薬は主に症状の増悪時や重症例に対して用いることが推奨されている。一方、本格発症前の最小持続炎症を制御するという観点から、初期治療における鼻噴霧用ステロイド薬の可能性が議論されている。自験例も含めて、いくつかのプラセボ対照二重盲検比較試験において、鼻噴霧用ステロイド薬を用いたスギ・ヒノキ花粉症に対する初期治療は、プラセボと比べて症状増悪およびQOL増悪を有意に抑制するという報告がある。一方、安全性については実薬とプラセボとの間に有意な差を認めなかった。さらには、発症後治療と比較しても本格飛散後の鼻症状および眼症状の増悪を有意に抑制した。以上の結果より、鼻噴霧用ステロイド薬を用いた花粉症初期治療は有効かつ安全な治療法である可能性が示唆された。今後は、初期治療の至適開始時期や飛散する花粉数による効果の変化などの検討も望まれる。(著者抄録)

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Language：Japanese   Publisher：(一社)日本鼻科学会  

急性浸潤型副鼻腔真菌症は眼窩や脳内に進展し極めて難治性で予後不良な疾患である。今回,急性リンパ性白血病の寛解導入療法中に発症し,不幸な転機となった鼻脳型ムーコル症の一例を経験したため,文献的考察を加えて報告する。症例は74歳,女性。当院血液内科で急性リンパ性白血病と診断され,入院2日目より寛解導入療法を開始した。治療開始後から徐々に左視力低下,軽い左眼周囲の痛みを感じ,入院21日目より左眼瞼腫脹,複視を認めるようになり,25日目に眼科受診。左眼球運動の全方向への障害,左眼圧の上昇,左視力低下を認め,CTで副鼻腔炎からの左眼窩蜂窩織炎の疑いにて同日当科紹介受診した。両側鼻内,特に左鼻副鼻腔粘膜は大部分が黒色で壊死性変化をきたしており,病理検査でムーコル症の診断となった。診断後からリポソーマルアムホテリシンBの全身投与を開始した。左眼球摘出も含めたデブリードマンを勧めるも,患者とその家族が拒否したため,入院32日目に鼻副鼻腔内の病変部位を内視鏡下鼻副鼻腔手術にて可及的に除去した。左眼窩内への操作は行わなかった。術後からアムホテリシンBによる鼻腔内洗浄を開始した。入院33日目には左眼光覚消失,37日目より口蓋の穿孔,鞍鼻が生じた。入院96日目に急性細菌性肺炎生じ,98日目に永眠された。拡大手術を行い,薬物治療を併用したとしても根治する保証はない非常に予後の悪い疾患のため,できるだけの早期診断と治療開始が必要と考えられた。(著者抄録)

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Language：Japanese   Publisher：岡山医学会  

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Language：Japanese   Publisher：耳鼻咽喉科臨床学会  

45歳男。3日前に急激な頸部痛、嚥下痛および頸部可動域制限が出現し、前医でロキソプロフェンナトリウムを処方されるも改善しなかった。血液検査で白血球数とCRP値の軽度高値を認め、CTで咽後部に低吸収領域を認めたが、膿瘍を疑う周囲の造影効果は認めなかった。また、頸長筋腱が停止する環軸椎前面に石灰沈着を認めた。なお、前医でのMRIではT2強調像で椎前部に高信号領域を認めていた。以上より石灰沈着性頸長筋腱炎と診断し、前医からのロキソプロフェンナトリウムは継続とし、シメチジン1回量200mgを朝夕食後で追加した。シメチジン開始翌日には、初診時の疼痛を10として6まで疼痛が改善し、3日後には2まで改善して頸部回旋が可能になった。初診後4日後には疼痛は1まで改善し、白血球数とCRP値も正常化した。初診後11日に疼痛は消失し、CTで環軸椎前面の石灰化が縮小し吸収傾向にあることを確認し、26日後にシメチジンを中止した。

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Language：Japanese   Publisher：(一社)日本鼻科学会  

骨膜は2層構造を認めるといわれている。今回,眼窩骨膜内に膿瘍形成をきたし,内視鏡下鼻副鼻腔手術(ESS)を行うことで改善を認めた一例を経験したので,文献的考察を加えて報告する。症例は35歳,男性。2012年X月昼より,鼻から額の左側に痛みがあり,近医耳鼻科受診。レボフロキサシン処方された。翌日,同部位の疼痛が激しくなり,当科紹介受診。副鼻腔CTでは左上顎洞,左篩骨洞,左前頭洞に陰影を認めるも,眼窩内に異常所見認めなかった。入院にてセフトリアキソン開始。2日後,左眼痛の悪化と左眼瞼腫脹を認め,造影CTにて眼窩骨膜下膿瘍が考えられる所見があり,同日,ESSを施行した。術中出血が多く,左上顎洞,左篩骨洞,左前頭洞から膿汁排出がみられ,術前の眼窩内陰影が軽度であったことから,紙様板への操作は行わなかった。術後,一旦左眼痛の改善認めるも,6日後,左眼瞼腫脹の明らかな増悪あり,同日再手術を施行した。左眼窩骨膜下膿瘍を考え,眼窩骨膜下を剥離するも膿汁排出を認めなかったが,骨膜を2層に剥離すると膿汁排出が認められた。術後経過良好にて14日後に退院となった。抗生剤による保存的治療に対して抵抗性である眼窩内感染症に対しては速やかに手術加療が必要であると感じた。本症例ではESSが非常に有効で,Chandlerの分類でgroup III以上の眼窩内感染症を認める場合は眼窩紙様板の除去と膿瘍開放術も必要と考えられた。画像上,眼窩骨膜下膿瘍と考えられる場合,眼窩紙様板を除去しても排膿されない時は,眼窩骨膜内に膿瘍形成を生じていることもあり注意が必要と思われた。(著者抄録)

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Language：Japanese   Publisher：(一社)日本鼻科学会  

Endoscopic modified Lothrop procedure(EMLP)は内視鏡下で両側前頭洞を単洞化する術式で,Frontal ethmoidal cells type 4などの通常の内視鏡下鼻副鼻腔手術(ESS)で前頭洞開放が困難な症例,前頭陥凹の癒着や骨増生を認める症例,眼窩壁や前頭洞後壁の骨欠損を認める症例,鼻外前頭洞手術の不成功症例,前頭洞嚢胞や前頭洞内腫瘍症例などに有用である。今回,EMLPが有用であった前頭陥凹骨腫例を経験したので,文献的考察を加えて報告する。症例は49歳女性。右眉上部に疼痛を自覚し,当院を紹介受診した。CT上,右前頭陥凹に径22mm大の骨腫像を認め,右前頭洞に充満する軟部陰影像も認めた。以上から前頭陥凹骨腫により鼻前頭管が閉塞して生じた前頭洞炎と診断した。抗菌薬等による保存的治療で改善しなかったので鼻内手術の適応とした。骨腫は前頭蓋底,右眼窩紙様板,篩板側壁,frontal beak,前頭洞中隔,右中鼻甲介と癒合していた。EMLPを施行し,それらの癒合部を安全に処理した上で骨腫を摘出し,前頭洞を広く開放した。術後経過は良好である。今回の結果から,前頭陥凹骨腫に対してEMLPの適用は有用であると考えられる。(著者抄録)

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Language：Japanese   Publisher：香川労災病院  

当院における2013年度の外来化学療法件数は5709件で、統計をとり始めた2006年度から7年連続で増加しており、2006年度の2倍以上に増加した。曜日別の件数をみると、2012年度には、最も多い曜日と少ない曜日で1.7倍の開きがあったが、2013年度は医師の外来日を変更したことで曜日によるバラツキが減少した。2009〜2013年度における件数の推移を原疾患別にみると、血液疾患のみが増加し続けており、乳癌は2011年まで減少傾向にあったが、その後増加し、血液疾患に次いで2番目の数となっている。2006〜2013年度における件数の推移を診療科別にみると、2010年までは外科の件数が圧倒的に多かったが、内科が急激に増加しており、2013年には外科を上回った。このほか、婦人科と泌尿器科の件数も緩やかに増加し続けている。当院の外来化学療法は今後も増加すると予想されることから、安全で効率的な外来化学療法室の運用を行えるよう、人員の確保や職員の教育システム構築が必要と考えられる。

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Language：Japanese   Publisher：香川労災病院  

当院では下垂体部腫瘍に対する手術のアプローチ方法として、以前は手術用顕微鏡を用いたSublabial approach(以下Hardy法)を施行していたが、21012年10月から内視鏡下経鼻手術(以下;経鼻)を導入した。今回、Hardy法を施行した群(10例)と経鼻施行群(15例)とで「手術時間」「入院日数」「合併症」などを比較検討した。結果、手術時間はHardy法群が平均290分、経鼻群が249分、入院日数はそれぞれ平均19.5日、15.3日であった。合併症はHardy法群で副腎機能低下を1例(10%)、鼻出血を1例(10%)、尿崩症を2例(20%)に認め、経鼻群で副腎機能低下を1例(7%)、尿崩症を6例(40%)に認めた。Hardy法と経鼻の両方を経験した症例が6例あり、その感想は総じて「経鼻のほうが術後に楽だった」とのことであった。代表例として経鼻群の1例を提示した。

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Language：Japanese   Publisher：(株)医学書院  

症例は68歳男性で、右眼痛、頭痛で近医CTにて浸潤性副鼻腔真菌症、副鼻腔腫瘍を疑い紹介受診した。両側内視鏡下副鼻腔手術を行い、両側上顎洞、右篩骨洞、右蝶形骨洞にアスペルギルス様真菌塊を認め、抜去後洗浄して終了した。術翌日よりボリコナゾール(VRCZ)内服を開始した。初診4ヵ月後のCTで右蝶形骨洞内の再燃を認め、右蝶形骨洞単洞化手術を行った。術後も生食洗浄を続けたが、早期に粘膜が肥厚し、術後1ヵ月で右蝶形洞内は肉芽に覆われた。初診8ヵ月後に右蝶形骨洞内の肉芽除去、真菌除去を行った。術前のβ-D-グルカン値の異常高値を認め、問診で無症状のためVRCZ内服を自己中断していたことが判明し、手術後にVRCZ内服のコンプライアンスは改善し、術後1ヵ月半で蝶形骨洞の肉芽は消失した。β-D-グルカン値も正常に回復し、服薬履行確認にtherapeutic drug monitoringを開始した。現在約1年経過で蝶形骨洞の所見も良好な状態を維持している。

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科学会  

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Language：Japanese   Publisher：(有)科学評論社  

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Language：Japanese   Publisher：(NPO)日本頭頸部外科学会  

glomangiopericytomaは鼻副鼻腔原発の血管周囲筋様細胞の表現型を伴う境界から低悪性度の新生物である。その発生頻度は全鼻副鼻腔腫瘍のうち1%以下とされており、非常にまれな腫瘍である。この腫瘍は従来hemangiopericytomaの一亜型とされてきたが、一般的な軟部組織に発生するhemangiopericytomaとは発生部位、生物学的挙動、組織学的特徴の観点から区別され、2005年のWHO基準にて正式に疾患分類として登録された。比較的新しい疾患概念であることなどから、hemangiopericytomaとの鑑別が十分なされていないことがあり、注意を要する疾患とされている。われわれは今回鼻出血を主訴に来院した右鼻腔原発のglomangiopericytomaに対し、内視鏡下に切除手術を施行し、良好な経過を得た1例を経験したので報告する。(著者抄録)

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：耳鼻咽喉科臨床学会  

86歳男。鼻中隔膿瘍は切開排膿によって改善した。蝶形骨洞アスペルギルス症に対しては内視鏡下鼻内副鼻腔手術による真菌塊除去後にボリコナゾール(VRCZ)投与を開始したが、症状は増悪した。その後、鼻中隔膿瘍の菌培養検査での真菌MIC値を参考にして抗真菌剤をミカファンギンナトリウムとイトラコナゾールに変更したところ、症状は改善した。本例はVRCZに抵抗性のアスペルギルス症であり、真菌MIC値は薬剤選択に非常に有用であった。

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67歳女性。咬合時の左顔面違和感を主訴に近医を受診、CT検査にて左翼口蓋窩腫瘍を疑われ、著者らの施設へ紹介となった。所見では副鼻腔CTで左上顎洞後方、翼口蓋窩に長径14mmと短径6mmのニ房性の嚢胞状腫瘤が認められた。また、MRIでは同部位にT1にて低信号、T2にて低信号と高信号が混在する腫瘤が確認された。以上、これらの画像所見を踏まえ、本症例は嚢胞性病変を考え、しばらく経過観察としていたが、左滲出性中耳炎を合併し、MRIで腫瘤サイズの増大とともに左乳突蜂巣に液体貯留が認められた。そこで、診断確定目的で内視鏡下鼻内副鼻腔手術を行なったところ、病理組織学的に翼口蓋窩に発生した類表皮嚢胞と診断された。経過は術後より咬合時の左顔面違和感が改善し、左滲出性中耳炎も治癒が得られた。目下、術後1年経過で開放部の閉塞や滲出性中耳炎の再燃はみられていない。

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科学会  

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Publishing type：Book review, literature introduction, etc.  

In Japan, pollen from Japanese cedar (Cryptomeria japonica) and Japanese cypress (Chamaecyparis obtusa), species that have been planted in approximately 4.5 and 2.6 million ha, respectively, is spread wide through aerial dispersion in spring. Consequently, Japanese cedar/cypress pollinosis (JCCP) is the major phenotype of allergic rhinitis (AR) in Japan, and significantly impairs the quality of life (QOL). Compared with Japanese cedar pollinosis, the pathogenesis and management of Japanese cypress pollinosis remain unclear. Cha o 1 and Cha o 2 are major allergens in Japanese cypress pollen, and have considerable homology with Cry j 1 and Cry j 2, respectively, in Japanese cedar pollen. Several other components were recently identified in Japanese cypress pollen, and may facilitate allergic inflammation via IgE-independent mechanisms. Allergen-specific CD4 + Th2 cells producing interleukin (IL)-4, IL-5, IL-13 and IL-31 are believed to play central roles in the pathogenesis of AR. The major human T cell epitopes in Cha o 1 and Cha o 2 have been identified. Compared with those in Cry j 1 and Cry j 2, both common and unique T cell epitopes in the cypress allergens have been characterized. Peripheral blood mononuclear cells (PBMCs) produced these Th2-type cytokines in response to a crude extract of Japanese cypress pollen. Among these cytokines, induction of antigen-specific IL-5 and IL-31 production is closely associated with the onset and exacerbation of Japanese cypress pollinosis, respectively. Allergen-specific immunotherapy using a standardized extract of Japanese cedar pollen is effective in controlling both naso-ocular symptoms and QOL during the period of cedar pollen dispersion, although the significant efficacy tends to be reduced during the period of cypress pollen dispersion, especially when the pollen dispersion is high. IL-5 production by PBMCs in response to the crude extract of Japanese cypress pollen did not differ significantly between patients with and without the immunotherapy, suggesting that unique component(s) in Japanese cypress pollen can induce IL-5 production, which is not fully suppressed by immunotherapy with the standardized extract of cedar pollen. The Practical Guideline for Management of Allergic Rhinitis in Japan recommends that patients who experience severe symptoms of pollinosis every year should receive early interventional treatment. Although early interventional treatment with a histamine H1 receptor antagonist (H1RA) is effective for Japanese cedar pollinosis, especially at the beginning of the season, this treatment has limitations for Japanese cypress pollinosis when exposure to the pollen is high. Combined therapy with a leukotriene receptor antagonist and/or intranasal corticosteroids may be required to fully control the worsening of JCCP during the cypress pollen season. © 2012 Blackwell Publishing Ltd.

DOI： 10.1111/j.1472-9733.2011.01156.x

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Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

DOI： 10.15036/arerugi.61.1536_3

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Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

DOI： 10.15036/arerugi.60.1265_1

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DOI： 10.15036/arerugi.60.437_1

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DOI： 10.15036/arerugi.60.1424_1

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Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

DOI： 10.15036/arerugi.60.503_1

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Language：Japanese   Publisher：(一社)日本アレルギー学会  

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Language：Japanese   Publisher：(株)医薬ジャーナル社  

本邦では、リン酸デキサメタゾンなどの全身性ステロイド薬はネブライザーなどの投与に限り副鼻腔炎に対する適応を有するが、鼻噴霧用ステロイド薬は副鼻腔炎に対する適応を有さない。一方、海外ではmometasone furoate(MFNS)やfluticasone propionate(FP)のようなバイオアベイラビリティが低く、局所への効果の強い鼻噴霧用ステロイド薬(intranasal corticosteroids;INCS)は急性副鼻腔炎に対して、抗生剤に上乗せすることで抗生剤単独よりも症状改善をきたすことが示されている。INCSが高用量の場合はさらに効果が増すことも示唆されている。INCS単剤投与の場合は、中等症以下の急性副鼻腔炎に対し、アモキシシリン単剤投与よりも効果が認められた報告もみられる。一方、INCS使用はプラセボと比較し目立った副作用は認められず、高い安全性が示されている。(著者抄録)

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Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

DOI： 10.15036/arerugi.59.430_4

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DOI： 10.15036/arerugi.59.1343_2

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Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

DOI： 10.15036/arerugi.58.423_4

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Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

DOI： 10.15036/arerugi.58.1287_1

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Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

DOI： 10.15036/arerugi.58.1288_2

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2009&ichushi_jid=J00009&link_issn=&doc_id=20091009240611&doc_link_id=10.15036%2Farerugi.58.1288_2&url=https%3A%2F%2Fdoi.org%2F10.15036%2Farerugi.58.1288_2&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

DOI： 10.15036/arerugi.58.1209_1

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Event date： 2019.3.19 - 2019.3.20

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Event date： 2017.9.1 - 2017.9.3

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Event date： 2017.6.16 - 2017.6.18

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Event date： 2010.11.25 - 2010.11.27

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Event date： 2010.2.18 - 2010.2.20

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Event date： 2009.10.29 - 2009.10.31

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Presentation type：Symposium, workshop panel (nominated)  

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Presentation type：Symposium, workshop panel (nominated)  

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Presentation type：Oral presentation (invited, special)  

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Presentation type：Oral presentation (invited, special)  

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Presentation type：Oral presentation (invited, special)  

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Presentation type：Poster presentation  

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