Updated on 2025/07/12

写真a

 
Seiichiro Makihara
 
Organization
Scheduled update Assistant Professor
Position
Assistant Professor
External link

Degree

  • Ph.D. ( 2012.3   Okayama University )

Research Interests

  • 鼻副鼻腔腫瘍

  • 免疫アレルギー

  • 鼻副鼻腔CT

  • 鼻副鼻腔手術

  • 経鼻頭蓋底手術

Research Areas

  • Life Science / Otorhinolaryngology

Education

  • Okayama University   大学院医歯薬学総合研究科  

    2006.4 - 2012.3

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  • Okayama University   医学部   医学科

    1998.4 - 2004.3

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Research History

  • 岡山大学病院   助教

    2022.4

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  • 香川労災病院   部長

    2017.4 - 2022.3

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  • 香川労災病院

    2011.11 - 2017.3

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  • 岡山赤十字病院

    2011.1 - 2011.7

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  • 岡山大学病院   医員

    2009.1 - 2011.1

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  • 福山医療センター

    2006.10 - 2008.12

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  • 岡山大学医学部・歯学部附属病院   医員

    2006.4 - 2006.9

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  • 岡山赤十字病院   臨床研修医

    2004.4 - 2006.3

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Professional Memberships

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Committee Memberships

  • 日本鼻科学会   臨床ハンズオン委員会 委員長  

    2024   

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  • 日本アレルギー学会専門医制度   試験問題作成委員会非常任委員  

    2023.10 - 2027.3   

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  • 日本鼻科学会   代議員  

    2023.7   

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Papers

  • Endoscopic surgical strategy for highly vascular pediatric sinonasal and pterygopalatine fossa tumors. Reviewed International journal

    Aiko Shimizu, Seiichiro Makihara, Minori Noda, Aya Murai, Mizuo Ando

    Auris, nasus, larynx   52 ( 3 )   243 - 247   2025.4

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Pediatric sinonasal tumors are rare, and minimally invasive approaches are preferred because of unknown long-term effects on development. We report three cases of highly vascular pediatric sinonasal and pterygopalatine fossa tumors that were successfully removed using an endonasal endoscopic approach with transcatheter arterial embolization (TAE). The patients (9-11 years old) had contrast-enhanced tumors in the left ethmoid sinus near the sphenopalatine foramen in case 1, in the right nasal cavity near the sphenopalatine foramen in case 2, and in the right pterygopalatine fossa in case 3, with diameters of 32, 50, and 61 mm, respectively. Computed tomography and magnetic resonance imaging demonstrated tumors with strong contrast enhancement and flow voids in all cases. TAE was performed in all cases on the day of surgery, followed by endoscopic sinus surgery with nasal septal modification. Pathology revealed pyogenic granuloma, nasal polyps, and juvenile angiofibroma. After TAE, tumor reduction improved visualization in case 1. Nasal septum manipulation enabled medial traction and tumor base identification in cases 2 and 3. The combination of preoperative TAE and septal modification proved effective for achieving complete endoscopic tumor removal. No complications occurred, and follow-up at 1-1.5 years showed no tumor recurrence or developmental abnormalities.

    DOI： 10.1016/j.anl.2025.04.006

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  • Identification of factors related to functional prognoses in craniopharyngiomas. Reviewed International journal

    Tsuyoshi Umeda, Yoshihiro Otani, Kentaro Fujii, Joji Ishida, Shuichiro Hirano, Yasuki Suruga, Naoya Kemmotsu, Ryoji Imoto, Yasuhito Kegoya, Ryo Mizuta, Yohei Inoue, Madoka Hokama, Seiichiro Makihara, Kosei Hasegawa, Kenichi Inagaki, Fumio Otsuka, Takao Yasuhara, Shota Tanaka

    Journal of neuro-oncology   2025.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    PURPOSE: Craniopharyngiomas are histologically benign tumors, but their proximity to vital neurovascular structures can significantly deteriorate functional prognoses and severely restrict patients' social interaction and activity. We retrospectively identified risk factors related to the functional prognoses in patients with craniopharyngioma treated at our center. METHODS: A retrospective analysis was conducted on 40 patients who underwent surgery for craniopharyngioma and follow-up at our institution between 2003 and 2022. Functional prognoses were evaluated in terms of obesity (body mass index [BMI] ≥ 25 for adults, BMI-Z ≥ 1.65 for children), visual function, endocrine function, and social participation. We investigated whether patient characteristics, tumor size, tumor location, hypothalamic involvement, surgical hypothalamic damage, extent of resection, and recurrence rate correlated with these functional prognostic factors. RESULTS: The median age at diagnosis was 28.0 years, with a median follow-up of 80.5 months. Postoperative obesity was present in 22 patients, and those with postoperative obesity had a significantly higher preoperative BMI or BMI-Z (preoperative BMI for adults: p = 0.074; preoperative BMI-Z for children: p = 0.020) and were significantly correlated with preoperative hypothalamic involvement grade 2 (p = 0.012) and surgical hypothalamic damage grade II (p = 0.0001). Deterioration in social participation was significantly associated with a larger tumor size (p = 0.023) and tumor recurrence (p = 0.0047). CONCLUSIONS: Patients with higher preoperative BMI or BMI-Z and hypothalamic involvement have a greater risk of postoperative obesity, and larger tumor size and recurrence can significantly deteriorate the rate of patients' social participation.

    DOI： 10.1007/s11060-024-04925-7

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  • Association Between Dinner-to-Bed Time and Gastroesophageal Reflux-Related Diseases in Children. Reviewed International journal

    Kensuke Uraguchi, Naomi Matsumoto, Toshiharu Mitsuhashi, Soshi Takao, Seiichiro Makihara, Mizuo Ando, Takashi Yorifuji

    Cureus   17 ( 1 )   e77709   2025.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    INTRODUCTION: Gastroesophageal reflux disease (GERD) is characterized by esophageal mucosal injury due to the reflux of gastroduodenal contents. Typical symptoms include heartburn and acid regurgitation. In addition, gastroesophageal reflux (GER) can influence conditions such as otitis media, rhinitis, and asthma. This study aimed to examine the association between dinner-to-bed time and GER-related diseases, such as otitis media, allergic rhinitis, and asthma. METHODS: This was a longitudinal cohort study using secondary data. Data were collected from a large-scale birth cohort study conducted in Japan including babies born in 2001 and 2010. Dinner-to-bed time was categorized as "longer dinner-to-bed time" (>120 minutes), "shorter dinner-to-bed time" (≤120 minutes or less), and "irregular dinner-to-bed time." Modified Poisson regression with robust variance was used to estimate risk ratios (RRs). RESULTS: A total of 60,392 children were included in this study. Children with shorter dinner-to-bed time had a higher risk of asthma (adjusted RR (aRR) = 1.10; 95% confidence interval (CI), 1.03-1.18) than those with longer dinner-to-bed time. However, no significant association was observed between shorter dinner-to-bed time and otitis media or allergic rhinitis. Furthermore, supplementary analyses revealed that the risk of asthma was significantly higher in children born in 2001 (aRR = 1.13; 95% CI, 1.04-1.22). CONCLUSION: This study showed that dinner-to-bed time within 120 minutes after dinner increases the risk of developing asthma. This underscores the importance of considering lifestyle modifications, as certain pediatric asthma cases may be influenced by behaviors that promote GER.

    DOI： 10.7759/cureus.77709

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  • 【指定難病 Up to Date】好酸球性副鼻腔炎

    牧原 靖一郎

    岡山医学会雑誌   136 ( 3 )   127 - 131   2024.12

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    Authorship：Lead author   Language：Japanese   Publisher：岡山医学会  

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  • 【内視鏡下鼻副鼻腔手術-基本とコツで上手くなる】内視鏡下鼻副鼻腔手術の実際 篩骨洞手術

    清水 藍子, 牧原 靖一郎

    耳鼻咽喉科・頭頸部外科   96 ( 13 )   1121 - 1127   2024.12

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    Language：Japanese   Publisher：(株)医学書院  

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  • 【第一線のエキスパートが教える耳科・鼻科における術前プランニングと手術テクニック】TACMI(transseptal access with crossing multiple incisions)法

    清水 藍子, 牧原 靖一郎

    ENTONI   ( 302 )   123 - 129   2024.10

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    Language：Japanese   Publisher：(株)全日本病院出版会  

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  • Endoscopic Transpterygoid Repair of Sphenoid Sinus Meningocele: A Comprehensive Case Report and Literature Review. Reviewed International journal

    Aiko Shimizu, Seiichiro Makihara, Ryoji Imoto, Koji Hirashita, Mizuo Ando

    Auris, nasus, larynx   51 ( 5 )   875 - 879   2024.8

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    We report a challenging and uncommon case involving a 53-year-old Japanese man with cerebrospinal fluid (CSF) leakage caused by a meningocele in the lateral recess of the sphenoid sinus. Our innovative treatment approach involved a combination of transpterygoid and endoscopic modified medial maxillectomy techniques, with special emphasis on the preservation of the sphenopalatine artery. This strategic preservation was pivotal to the successful use of the ipsilateral nasoseptal flap for reconstruction, which played a crucial role in the prevention of postoperative CSF leakage. Otolaryngologists and neurosurgeons collaborated to perform the bath-plugging technique; effective collaboration was instrumental to the success of the procedure. This report highlights significant advancement from conventional frontal craniotomy to a more sophisticated endoscopic technique, shows the importance of meticulous surgical planning and execution, emphasizes careful preservation of critical anatomical structures during complex neurosurgical and otolaryngological procedures, and underscores the evolving landscape of surgical approaches for managing complex medical conditions.

    DOI： 10.1016/j.anl.2024.08.003

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  • Shifting paradigms in endoscopic sinus surgery: a comprehensive analysis from Japan's national database. Reviewed International journal

    Seiichiro Makihara, Kensuke Uraguchi, Shohei Fujimoto, Aiko Shimizu, Shin Kariya, Mitsuhiro Okano, Takashi Yorifuji, Mizuo Ando

    Acta oto-laryngologica   144 ( 9 )   1 - 6   2024.8

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: In 2013, Japan established a standardized classification system for categorizing endoscopic sinus surgery (ESS) into types I-V, yet no evaluation has been conducted thereof. OBJECTIVE: We assessed the ESS trends and status in Japan, focusing on outpatient and inpatient surgeries. MATERIAL AND METHODS: This descriptive retrospective cohort study used Japan's National Database of Health Insurance Claims and Specific Health Checkups between 2014 and 2021. The distribution of ESS types I-V and outpatient and inpatient surgeries was analysed, along with age groups and regional differences, focusing on ESS type III. RESULTS: Overall, 427,813 ESS procedures were performed, with types III and IV being most common. Outpatient ESS type III increased substantially compared to inpatient surgeries. Younger individuals favoured outpatient ESS type III over inpatient surgeries, with substantial regional variations across prefectures. CONCLUSIONS AND SIGNIFICANCE: The adoption of a standardized ESS classification in Japan has facilitated a detailed understanding of surgical trends. The shift toward outpatient surgeries, especially for type III ESS, aligns with global trends toward minimally invasive procedures and reflects changing patient preferences and healthcare delivery practices. Consequently, continuous monitoring and research are crucial for adapting surgical practices to the evolving healthcare needs and patient expectations.

    DOI： 10.1080/00016489.2024.2389179

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  • Pneumocephalus with Inverted Papilloma in the Frontoethmoidal Sinus: Case Report and Literature Review. Reviewed

    Seiichiro Makihara, Yoshihiro Otani, Kensuke Uraguchi, Sawako Ono, Aiko Shimizu, Ryosuke Ikemachi, Yosuke Okazaki, Tomoyuki Ota, Hiroshi Matsumoto, Shotaro Miyamoto, Munechika Tsumura, Seiya Hayashi, Michiari Umakoshi, Koji Hirashita, Mizuo Ando

    Acta medica Okayama   78 ( 4 )   337 - 343   2024.8

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Here, we describe the unique case of a pneumocephalus originating from an inverted papilloma (IP) in the frontoethmoidal sinus. A 71-year-old man with diabetes presented with headaches and altered consciousness. Imaging revealed the pneumocephalus together with bone destruction in the left frontal sinus. He underwent simultaneous endoscopic endonasal and transcranial surgery using an ORBEYE exoscope. Pathological diagnosis of the tumor confirmed IP. Post-surgery, the pneumocephalus was significantly resolved and the squamous cell carcinoma antigen level, which had been elevated, decreased. This case underscores the importance of a multidisciplinary approach and innovative surgical methods in treating complex sinonasal pathologies.

    DOI： 10.18926/AMO/67550

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  • Neurectomy for allergic rhinitis in Japan: Increasing trends and surgeon preferences. Reviewed International journal

    Seiichiro Makihara, Kei Hosoya, Kensuke Uraguchi, Yohei Maeda, Taro Komachi, Takashi Yorifuji, Mizuo Ando, Shoji Matsune, Kimihiro Okubo

    Auris, nasus, larynx   51 ( 5 )   834 - 839   2024.7

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVE: There is no consensus on the optimal surgical technique for allergic rhinitis (AR). Furthermore, the appropriateness of surgical intervention in children and older individuals remains debatable. This study aimed to analyze trends and patterns in the surgical management of AR in Japan, focusing on parasympathetic neurectomy. METHODS: Using the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB), we conducted a comprehensive review of procedures performed between April 2014 and March 2022. In addition, a cross-sectional survey targeting otolaryngologists across Japan was conducted to gather insights into surgical preferences and practices. RESULTS: The NDB data showed an increasing trend in neurectomies, with the most frequent age group being 25-29 years; the procedure was also performed in pediatric and older patients. The survey among otolaryngologists indicated that 58.2 % of surgeons preferred peripheral branch neurectomy of the posterior nasal nerve. The findings of this study also indicated a cautious approach toward conducting these procedures in children, with 51.2 % of surgeons considering patients less than 18 years of age unsuitable for the procedure. CONCLUSION: This study highlighted a shift toward simple and minimally invasive surgical methods, such as peripheral branch neurectomy, in Japan. However, further research is needed to understand the long-term outcomes and refine the surgical techniques. The findings of this study also emphasized the need for age-specific considerations when treating pediatric and older patients with AR.

    DOI： 10.1016/j.anl.2024.07.005

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  • Role of nasal polyp-derived innate lymphoid cells in staphylococcal enterotoxin-induced cellular responses. Reviewed International journal

    Kengo Kanai, Aiko Oka, Shin Kariya, Tazuko Fujiwara, Takaya Higaki, Seiichiro Makihara, Takenori Haruna, Maki Akamatsu, Kazunori Nishizaki, Mizuo Ando, Mitsuhiro Okano

    Allergology international : official journal of the Japanese Society of Allergology   73 ( 3 )   477 - 480   2024.7

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  • Pediatric otitis media in Japan: A nationwide longitudinal study of the pre- and post-pneumococcal conjugate vaccine eras born in 2001 and 2010. Reviewed International journal

    Kensuke Uraguchi, Naomi Matsumoto, Toshiharu Mitsuhashi, Soshi Takao, Seiichiro Makihara, Mizuo Ando, Takashi Yorifuji

    Vaccine   42 ( 19 )   4081 - 4087   2024.5

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    BACKGROUND: Otitis media (OM) is a prevalent respiratory disease in children and poses significant public health challenges due to its impact on child health and economic burdens. However, there have no nationwide epidemiological studies conducted in Japan. This study investigates the epidemiological trends of OM in Japan, taking into account the impact of the 7-valent pneumococcal conjugate vaccine (PCV7) introduction. METHOD: This study was retrospective cohort study using secondary data on the nationwide longitudinal birth cohort. This survey followed two cohorts born in 2001 (pre-PCV era) and 2010 (post-PCV era) until the age of 9. Every year, parents were surveyed about their children's health status, including occurrences of OM. The annual period prevalence and cumulative incidence of OM were assessed in this study, and the two cohorts were compared using a modified Poisson regression model adjusted environmental factors with the 2001 cohort as reference. RESULT: The study included 47,015 children from the 2001 cohort and 38,554 from the 2010 cohort. Peak annual period prevalence of OM varied by era. Cumulative incidence was 13.8 % for the 2001 cohort and 18.5 % for the 2010 cohort by 1.5 years of age and 28.9 % and 33.3 %, respectively, by 3.5 years of age. In particular, from the fourth survey onward, covering ages 2.5-3.5 years, a shift was observed from an increased risk to a decreased risk of OM. CONCLUSION: This nationwide longitudinal study emphasizes variations in OM epidemiology across Japan over time, with changes potentially influenced by the introduction of PCV7. In this study, due to the absence of individual PCV7 vaccination data, the effect of PCV7 was estimated based on the vaccination rate at the population level. The results suggest a notable decrease in the incidence of OM in later years, aligning with the increased uptake of PCV7.

    DOI： 10.1016/j.vaccine.2024.05.020

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  • Combined simultaneous endoscopic endonasal and transcranial surgery using high-definition three-dimensional exoscope for malignant tumors of the anterior skull base. Reviewed International journal

    Seiichiro Makihara, Yoshihiro Otani, Kensuke Uraguchi, Aiko Shimizu, Aya Murai, Takaya Higaki, Naoki Akisada, Shohei Fujimoto, Takuma Makino, Joji Ishida, Kentaro Fujii, Takao Yasuhara, Tomoyuki Ota, Hiroshi Matsumoto, Mizuo Ando

    Head & neck   46 ( 5 )   1074 - 1082   2024.3

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Advanced surgical interventions are required to treat malignancies in the anterior skull base (ASB). This study investigates the utility of endoscopic endonasal and transcranial surgery (EETS) using a high-definition three-dimensional exoscope as an alternative to traditional microscopy. METHODS: Six patients with carcinomas of varying histopathologies underwent surgery employing the EETS maneuver, which synchronized three distinct surgical modalities: harvesting of the anterolateral thigh flap, initiation of the transnasal technique, and initiation of the transcranial procedure. RESULTS: The innovative strategy enabled successful tumor resection and skull base reconstruction without postoperative local neoplastic recurrence, cerebrospinal fluid leakage, or neurological deficits. CONCLUSION: The integration of the exoscope and EETS is a novel therapeutic approach for ASB malignancies. This strategy demonstrates the potential of the exoscope in augmenting surgical visualization, enhancing ergonomics, and achieving seamless alignment of multiple surgical interventions. This technique represents a progressive shift in the management of these complex oncological challenges.

    DOI： 10.1002/hed.27724

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  • Various arrangements of pharyngeal flap in soft palate reconstruction after cancer treatment. Reviewed International journal

    Hiroshi Matsumoto, Tomoyuki Ota, Motoi Kato, Takuma Makino, Seiichiro Makihara, Mizuo Ando, Yoshihiro Kimata

    Head & neck   46 ( 7 )   1573 - 1581   2024.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: The pharyngeal flap (PF) is useful for reconstruction of soft palate defects, but effective arrangements of PF for various types of soft palate defects are controversial. Here, we classify three types of soft palate defects and discuss the arrangements of PF and their functional prognosis. METHODS: Reconstruction was performed based on the classification of the defects. Clinical details were collected, and postoperative function was analyzed. RESULTS: Eight patients were included in the study. The defect sizes ranged from 25 (width) × 40 (depth) to 40 × 60 mm. Six patients underwent pharyngeal flap reconstruction with free-flap reconstruction, and two underwent pharyngeal flap reconstruction. The pharyngeal flap was harvested at the maximum width of the posterior pharyngeal wall, ranging from 25 to 40 mm in length. Eating and speaking functions were maintained in all patients. CONCLUSIONS: Good postoperative function can be maintained by narrowing the velopharyngeal space with a pharyngeal flap.

    DOI： 10.1002/hed.27712

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  • 高齢者に多い耳鼻咽喉科疾患 鼻領域 副鼻腔嚢胞

    清水 藍子, 牧原 靖一郎

    鼻アレルギーフロンティア   24 ( 1 )   20 - 24   2024.2

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    Language：Japanese   Publisher：(株)メディカルレビュー社  

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  • Chronic rhinosinusitis possibly associated with decreased lung function in chronic cough patients. Reviewed International journal

    Pengfei Zhao, Shin Kariya, Takaya Higaki, Seiichiro Makihara, Toru Rikimaru, Mitsuhiro Okano, Mizuo Ando

    Brazilian journal of otorhinolaryngology   90 ( 4 )   101424 - 101424   2024

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    OBJECTIVES: The purpose of this study is to investigate the lung function in Chronic Rhinosinusitis (CRS) patients with Chronic Cough (CC). METHODS: A total of 1413 CC patients were retrospectively screened and 109 CRS patients with CC were enrolled. Lung function, Lund-Mackay Computed Tomography (CT) score, smoking status, peripheral blood eosinophil count, and immunoglobulin E concentration in serum samples, and Sino-Nasal Outcome Test were examined. Normal control subjects are also recruited. RESULTS: The Forced Expiratory Volume in 1 second (FEV1.0), Percent Predicted FEV1.0, and FEV1.0/Forced Vital Capacity (FVC) ratio in the patients were significantly low as compared with the control subjects. The FEV1.0/FVC ratio was negatively correlated with the Lund-Mackay CT scores of the patients with a high CT score. CONCLUSIONS: The CRS patients with CC should be investigated with lung function. In addition, the multidisciplinary evaluation including a pulmonologist is needed to manage the CRS patients with CC. LEVEL OF EVIDENCE: Level 4.

    DOI： 10.1016/j.bjorl.2024.101424

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  • Association Between Clinical Remission of Infantile-Onset Allergic Rhinitis During the School-Age Period and the Type of Housing: A Longitudinal Population-Based Japanese Study. Reviewed International journal

    Kensuke Uraguchi, Naomi Matsumoto, Toshiharu Mitsuhashi, Soshi Takao, Seiichiro Makihara, Mizuo Ando, Takashi Yorifuji

    Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners   38 ( 4 )   629 - 636   2023.12

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    This study investigated the association between housing type and clinical remission of infantile-onset allergic rhinitis (AR) in 53,575 children born in 2001 in Japan. Infantile-onset AR was defined as the presence of AR symptoms reported between ages 1.5 and 4.5 years, and remission was assessed between ages 10 and 12. The type of housing was categorized into detached houses and multi-unit residential buildings with 1-2, 3-5, or ≥6 floors. Among the 4,352 infantile-onset AR, 42.9% experienced remission. Notably, living in multi-unit residential buildings, particularly those with 1-2 and ≥6 floors, was positively associated with AR remission.

    DOI： 10.1016/j.pedhc.2023.11.011

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  • Risk Factors for Anterior Skull Base Injury in Endoscopic Sinus Surgery Reviewed International journal

    Seiichiro Makihara, Kensuke Uraguchi, Tomoyuki Naito, Aiko Shimizu, Aya Murai, Takaya Higaki, Yohei Noda, Shin Kariya, Mitsuhiro Okano, Mizuo Ando

    Cureus   15 ( 11 )   e49273   2023.11

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Objectives This retrospective study aimed to investigate the relationships between the Keros classification, the Gera classification, the vertical height of the posterior ethmoid roof (ER), and anterior ethmoidal artery (AEA) types in Japanese patients. Methods We investigated the computed tomography (CT) slices of paranasal sinuses (120 sides) of 60 patients; measured the cribriform plate (CP) depth, lateral lamella CP angle (LLCPA), and vertical height of the lateral ER from the hard palate (LERHP) at the coronal plane of the posterior ethmoidal artery (PEA); and reviewed the AEA types, whether floating or non-floating. Results CP depth was positively correlated with LLCPA (r=0.63; p<0.01) and the height of LERHP (r=0.19; p<0.05). The height of the LERHP in females was significantly lower than that in males. With increased CP depth, floating AEAs became prevalent (p<0.001). Conclusion In females, low height of the posterior ethmoid sinus roof, where cerebrospinal fluid (CSF) leaks occurred while penetrating the basal lamella, often existed; the heights positively correlated with the Keros classification in Japanese patients. The Keros and Gera classifications, AEA type, and posterior ER height do not individually constitute a complete risk assessment but may correlate, preventing major complications, such as CSF leak and orbital hemorrhage.

    DOI： 10.7759/cureus.49273

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  • Nasopharyngeal low-grade papillary schneiderian carcinoma with cervical metastasis. Reviewed International journal

    Kensuke Uraguchi, Kenji Nishida, Takuma Makino, Seiichiro Makihara, Masahiro Tabata, Shin Kariya, Mizuo Ando

    Auris, nasus, larynx   50 ( 5 )   821 - 826   2023.10

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    Low-grade papillary Schneiderian carcinoma (LGPSC) is a rare and newly described type of cancer arising from the Schneiderian epithelium. Owing to cellular atypia, it is difficult to differentiate this type from other papillomas and malignancies. Although this condition remains unclear, it is associated with mortality and recurrence. Therefore, treating physicians should be aware of the possibility of LGPSC for prompt diagnosis and treatment. In this article, we present an additional case of nasopharyngeal LGPSC with cervical lymph node metastasis and reviewed the 14 cases reported thus far in the literature. A 76-year-old female was referred to our department for detailed examination of nasopharyngeal and cervical lymph node tumors detected by positron emission tomography-computed tomography. Based on the biopsy of the nasopharyngeal tumor, we suspected LGPSC. Considering the clinical course and pathological findings, the patient was diagnosed with cervical lymph node metastasis through neck dissection. We performed radiotherapy for the primary lesion of the nasopharynx, which led to the disappearance of the tumor. After 13 months following the radiotherapy, the patient died from a recurrence of retroperitoneal liposarcoma without the recurrence of LGPSC.

    DOI： 10.1016/j.anl.2022.12.010

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  • 内視鏡下鼻副鼻腔手術後のナゾポアによる鼻内パッキングの有用性 Reviewed

    岡 愛子, 小池 隆史, 北村 寛志, 上斗米 愛実, 金井 健吾, 渡部 佳弘, 今西 順久, 野口 佳裕, 赤松 摩紀, 牧原 靖一郎, 岡野 光博

    耳鼻咽喉科・頭頸部外科   95 ( 10 )   849 - 853   2023.9

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    Language：Japanese   Publisher：(株)医学書院  

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  • Association between handwashing and gargling education for children and prevention of respiratory tract infections: a longitudinal Japanese children population-based study Reviewed International journal

    Kensuke Uraguchi, Toshiharu Mitsuhashi, Naomi Matsumoto, Soshi Takao, Seiichiro Makihara, Mizuo Ando, Takashi Yorifuji

    European Journal of Pediatrics   182 ( 9 )   4037 - 4047   2023.7

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    PURPOSE: A longitudinal study was conducted to examine the effects of handwashing and gargling education for children on the prevention of respiratory tract infections (RTIs) in children in Japan. METHODS: The study included 38,554 children born in 2010 who were enrolled in a longitudinal study. Information on children's hygiene education regarding handwashing and gargling was collected in a survey at the age of 3.5 years. Based on parents' reports of doctors' diagnoses, airway infections and influenza events in the 12-month duration before the survey were evaluated for RTIs at the ages of 4.5 and 9 years. Poisson regression with robust variance was performed to examine the effects of hygiene education on RTIs prevention. The supplementary analysis was stratified by household income. RESULTS: Children were categorized into different groups: 38% in the handwashing and gargling group, 29% in the handwashing group, 0.1% in the gargling group, and 9.7% in the no-education group. Exclusions were made for non-respondent children (23%) and those in the gargling group. Hygiene education was associated with decreased influenza at the age of 4.5 years in the handwashing (adjusted RR [aRR] = 0.8; 95% CI, 0.8-0.9) and handwashing and gargling groups (aRR = 0.8; 95% CI, 0.8-0.9) compared with no education. However, no preventive effects on airway infections at the age of 4.5 and 9, influenza at the age of 9, or hospitalization between the ages of 3.5 and 9 years were detected. Handwashing and gargling could significantly prevent influenza in low-income households (aRR = 0.7; 95% CI, 0.6-0.8).     Conclusions: Gargling education was widespread and mostly combined with handwashing education in Japan. Hygiene education significantly affected prevention of influenza infections at the age of 4.5 years, especially in low-income households. WHAT IS KNOWN: • Previous intervention studies showed handwashing and gargling are effective in preventing respiratory tract infections. WHAT IS NEW: • We conducted a longitudinal study on handwashing and gargling education in Japanese children and found that handwashing and gargling were widely practiced together. • Handwashing and gargling education were related to a reduction in influenza, particularly in low-income households.

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  • Macroarray expression analysis of cytokines and prostaglandin metabolism-related genes in chronic rhinosinusitis Reviewed International journal

    Aiko Oka, Kengo Kanai, Takaya Higaki, Seiichiro Makihara, Yohei Noda, Shin Kariya, Mizuo Ando, Wataru Nishimura, Mitsuhiro Okano

    Journal of Allergy and Clinical Immunology: Global   2 ( 3 )   100123 - 100123   2023.6

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    BACKGROUND: Chronic rhinosinusitis (CRS) can be divided into endotypes by functional or pathophysiologic findings. OBJECTIVE: The aim of this study was to analyze the expression of cytokines, prostaglandin (PG) synthases, and their receptors related to the pathogenesis of CRS, especially those contributing to nasal polyp (NP) formation. METHODS: NPs and uncinate tissue (UT) samples were collected from 90 patients who underwent endoscopic sinus surgery. They included 75 patients with CRS (including 45 with eosinophilic CRS [eCRS] and 30 with non-eCRS) and 15 patients without CRS. A total of 30 genes were selected for our original DNA array plate to analyze the levels of expression of 10 cytokines (IFN-γ, IL-4, IL-5, IL-10, IL-13, IL-17A, IL-22, IL-25, IL-33, and TSLP), 4 prostaglandin synthases (prostaglandin D2 [PGD2] synthase, prostaglandin E2 synthase, COX-1, and COX-2), and their 16 receptors. Clustering analysis was performed according to the expression results, and clinical findings of patients from each cluster were investigated. RESULTS: The samples could be divided into 3 clusters. Cluster 1 showed elevated levels of expression of IL4, IL5, IL13, TSLP, IL1RL1 (ST2 [an IL-33 receptor]), HPGDS, and GPR44 (CRTH2, a PGD2 receptor); cluster 2 showed elevated levels of expression of IL17A and PTGES; and cluster 3 showed an elevated level of expression of IL25. Regarding clinical features, the main characteristics of each cluster were as follows: NPs from patients with eCRS for cluster 1, NPs and/or UT samples from patients with non-eCRS for cluster 2, and UTs from patients with non-CRS for cluster 3. CONCLUSION: The results suggest that there are associations between type 2 inflammation/PGD2 and eCRS and also between type 3 inflammation/prostaglandin E2 and non-eCRS.

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  • Serum 1,25-dihydroxyvitamin D3 Levels in Patients with Eosinophilic Chronic Rhinosinusitis. Reviewed

    Seiichiro Makihara, Shin Kariya, Shotaro Miyamoto, Kensuke Uraguchi, Aiko Oka, Munechika Tsumura, Yohei Noda, Mizuo Ando, Mitsuhiro Okano

    Acta medica Okayama   76 ( 5 )   527 - 533   2022.10

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    DOI： 10.18926/AMO/64033

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  • 咽喉頭浮腫を合併したムンプス感染症の1例 Reviewed

    内藤 智之, 牧原 靖一郎, 津村 宗近, 松本 淳也, 假谷 伸, 安藤 瑞生

    耳鼻咽喉科・頭頸部外科   94 ( 11 )   979 - 982   2022.10

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  • 甲状腺悪性リンパ腫に対して輪状軟骨開窓術を施行した1例 Reviewed

    松本 淳也, 牧原 靖一郎, 内藤 智之, 土井 彰, 小桜 謙一, 假谷 伸, 安藤 瑞生

    耳鼻咽喉科臨床   115 ( 7 )   619 - 624   2022.7

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  • ANL Secondary Publication 感染性副鼻腔嚢胞による鼻性眼窩内合併症の検討

    牧原 靖一郎, 假谷 伸, 岡野 光博, 内藤 智之, 津村 宗近, 西崎 和則

    日本耳鼻咽喉科頭頸部外科学会会報   125 ( 6 )   1041 - 1042   2022.6

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  • Subclinical obstructive lung function changes in patients with sinus fungus ball. Reviewed International journal

    Seiichiro Makihara, Shin Kariya, Ryotaro Omichi, Shotaro Miyamoto, Tomoyuki Naito, Kensuke Uraguchi, Aiko Oka, Munechika Tsumura, Mitsuhiro Okano, Mizuo Ando

    Allergology international : official journal of the Japanese Society of Allergology   71 ( 4 )   539 - 541   2022.4

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    DOI： 10.1016/j.alit.2022.03.003

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  • Mapping naso-ocular symptom scores to EQ-5D-5L utility values in Japanese cedar pollinosis Reviewed International journal

    Hiroshi Kumanomidou, Kengo Kanai, Aiko Oka, Takenori Haruna, Yuji Hirata, Sei ichiro Makihara, Takaya Higaki, Maki Akamatsu, Yoshitaka Okamoto, Shunya Ikeda, Mitsuhiro Okano

    Allergology International   71 ( 2 )   207 - 213   2022.4

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    DOI： 10.1016/j.alit.2021.11.002

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  • 【CT典型所見アトラス-まずはここを診る!】鼻副鼻腔領域 鼻副鼻腔腫瘍/頭蓋底疾患 乳頭腫/血瘤腫・血管腫・血管線維腫/鼻副鼻腔悪性腫瘍(上顎がん・嗅神経芽細胞腫)/髄膜脳瘤・髄膜瘤

    牧原 靖一郎, 假谷 伸

    耳鼻咽喉科・頭頸部外科   94 ( 4 )   336 - 341   2022.4

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  • Clinicopathologic Analysis of Sinonasal Inverted Papilloma, with Focus on Human Papillomavirus Infection Status. Reviewed International journal

    Munechika Tsumura, Seiichiro Makihara, Asami Nishikori, Yuka Gion, Toshiaki Morito, Shotaro Miyamoto, Tomoyuki Naito, Kensuke Uraguchi, Aiko Oka, Tomoyasu Tachibana, Yorihisa Orita, Shin Kariya, Mitsuhiro Okano, Mizuo Ando, Yasuharu Sato

    Diagnostics (Basel, Switzerland)   12 ( 2 )   2022.2

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    DOI： 10.3390/diagnostics12020454

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  • Dermatomyositis With Carcinoma of Unknown Primary Disease in the Head and Neck Diagnosed by Muscle Biopsy During Neck Dissection. Reviewed International journal

    Kensuke Uraguchi, Seiichiro Makihara, Makoto Tsugita, Toshiaki Morito, Shin Kariya, Mizuo Ando

    JAMA otolaryngology-- head & neck surgery   148 ( 2 )   195 - 196   2022.2

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    DOI： 10.1001/jamaoto.2021.3392

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  • TACMI法とEndoscopic Denker's Approachの併用により摘出しえた鼻腔血管腫の1例 Reviewed

    松本 淳也, 牧原 靖一郎, 大村 和弘, 内藤 智之, 土井 彰, 假谷 伸, 安藤 瑞生

    頭頸部外科   31 ( 3 )   293 - 299   2022.2

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  • Endoscopic tri-port approach法にて一塊切除した若年性血管線維腫例 Reviewed

    牧原 靖一郎, 大村 和弘, 宮本 翔太郎, 内藤 智之, 浦口 健介, 津村 宗近, 假谷 伸, 岡野 光博, 安藤 瑞生

    日本鼻科学会会誌   60 ( 4 )   546 - 552   2021.12

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  • Total en bloc resection for sinonasal squamous cell carcinoma by endoscopic endonasal surgery with Draf IIb procedure with video Reviewed

    K. Uraguchi, S. Makihara, K. Kozakura

    European Annals of Otorhinolaryngology, Head and Neck Diseases   138   119 - 121   2021.11

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    DOI： 10.1016/j.anorl.2021.04.009

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  • 【手術道具・材料はこう使う!-プロに学ぶ基本とコツ】鼻科領域 止血資材/創傷被覆材/フィブリン糊

    牧原 靖一郎

    耳鼻咽喉科・頭頸部外科   93 ( 11 )   915 - 919   2021.10

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  • Underwater posterior nasal neurectomy compared to resection of peripheral branches of posterior nerve in severe allergic rhinitis. Reviewed International journal

    Seiichiro Makihara, Mitsuhiro Okano, Syotaro Miyamoto, Kensuke Uraguchi, Munechika Tsumura, Shin Kariya, Mizuo Ando

    Acta oto-laryngologica   141 ( 8 )   780 - 785   2021.8

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    DOI： 10.1080/00016489.2021.1925151

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  • Dysphagia in a Patient with Asymmetric Elevation of the Hyoid Bone. Reviewed International journal

    Kensuke Uraguchi, Seiichiro Makihara, Shin Kariya

    Dysphagia   36 ( 4 )   761 - 763   2021.8

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    DOI： 10.1007/s00455-020-10196-x

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  • 経鼻内視鏡手術で摘出したskip病変を伴う鼻腔粘膜悪性黒色腫症例 Reviewed

    浦口 健介, 小桜 謙一, 牧原 靖一郎, 土井 彰, 假谷 伸

    日本鼻科学会会誌   60 ( 1 )   1 - 5   2021.4

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  • Effect of Prostaglandin D<inf>2</inf> on mRNA Expression of Three Isoforms of Hyaluronic Acid Synthase in Nasal Polyp Fibroblasts Reviewed International journal

    Yuji Hirata, Shin Kariya, Kengo Kanai, Tazuko Fujiwara, Sei Ichiro Makihara, Ryotaro Omichi, Takaya Higaki, Takenori Haruna, Aiko Oka, Kazunori Nishizaki, Mitsuhiro Okano

    American Journal of Rhinology and Allergy   35 ( 1 )   44 - 51   2021.1

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    DOI： 10.1177/1945892420932781

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  • A case of rhinocerebral mucormycosis with brain abscess drained by endoscopic endonasal skull base surgery. Reviewed International journal

    Kensuke Uraguchi, Kenichi Kozakura, Satoshi Oka, Takaya Higaki, Seiichiro Makihara, Toshi Imai, Akira Doi, Tsuyoshi Ohta, Shin Kariya, Kazunori Nishizaki

    Medical mycology case reports   30   22 - 25   2020.12

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    DOI： 10.1016/j.mmcr.2020.09.004

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  • Orbital complications of infected mucocele in the paranasal sinuses. Reviewed International journal

    Seiichiro Makihara, Shin Kariya, Mitsuhiro Okano, Tomoyuki Naito, Munechika Tsumura, Kazunori Nishizaki

    Auris, nasus, larynx   47 ( 6 )   990 - 995   2020.12

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    DOI： 10.1016/j.anl.2020.05.012

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  • 都市部と郊外における昆虫アレルゲン感作の実態と、昆虫単独感作例の臨床免疫学的特徴 Reviewed

    岡 愛子, 小山田 匠吾, 岡 晋一朗, 古舘 佐起子, 高橋 優宏, 岩崎 聡, 赤松 摩紀, 野口 佳裕, 假谷 伸, 金井 健吾, 牧原 靖一郎, 西崎 和則, 岡野 光博

    耳鼻咽喉科免疫アレルギー   38 ( 3 )   57 - 63   2020.12

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  • 脳神経外科、耳鼻咽喉科が連携した下垂体、傍鞍部腫瘍に対する経鼻的内視鏡手術の取組み

    井本 良二, 平下 浩司, 多々納 幹貴, 川井 伸彦, 柚木 正敏, 吉野 公博, 牧原 靖一郎, 内藤 智之, 津村 宗近

    香川労災病院雑誌   ( 26 )   1 - 7   2020.12

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  • 重症睡眠時無呼吸症候群を伴った成人ソトス症候群の1例 Reviewed

    浦口 健介, 牧原 靖一郎, 内藤 智之, 松本 淳也, 津村 宗近, 假谷 伸

    耳鼻咽喉科・頭頸部外科   92 ( 12 )   1031 - 1036   2020.11

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  • 経眼窩アプローチを併用し、内視鏡下に一塊切除した嗅神経芽細胞腫例 Reviewed

    津村 宗近, 牧原 靖一郎, 大村 和弘, 内藤 智之, 松本 淳也, 假谷 伸, 岡野 光博, 西崎 和則

    頭頸部外科   30 ( 1 )   119 - 125   2020.6

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  • Unilateral mucosal advancement flapによる鼻中隔穿孔閉鎖例 Reviewed

    牧原 靖一郎, 内藤 智之, 津村 宗近, 假谷 伸, 岡野 光博, 西崎 和則

    頭頸部外科   30 ( 1 )   113 - 118   2020.6

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  • Role of Macrophage Migration Inhibitory Factor in NLRP3 Inflammasome Expression in Otitis Media. Reviewed International journal

    Shin Kariya, Mitsuhiro Okano, Pengfei Zhao, Yukihide Maeda, Yuko Kataoka, Takaya Higaki, Seiichiro Makihara, Jun Nishihira, Tomoyasu Tachibana, Kazunori Nishizaki

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology   41 ( 3 )   364 - 370   2020.3

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    DOI： 10.1097/MAO.0000000000002537

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  • ポリグリコール酸フェルト(デュラウェーブ)を用いて頭蓋底硬膜再建した2症例 Reviewed

    浦口 健介, 小桜 謙一, 牧原 靖一郎, 福田 真紀, 土井 彰, 太田 剛史

    日本耳鼻咽喉科学会会報   123 ( 3 )   257 - 263   2020.3

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  • Corrigendum to “Effect of prostaglandin D2 on VEGF release by nasal polyp fibroblasts” (Allergology International (2016) 65(4) (414–419), (S1323893016300259), (10.1016/j.alit.2016.03.003)) International journal

    Kengo Kanai, Mitsuhiro Okano, Tazuko Fujiwara, Shin Kariya, Takenori Haruna, Ryotaro Omichi, Sei ichiro Makihara, Yuji Hirata, Kazunori Nishizaki

    Allergology International   69 ( 1 )   163 - 163   2020.1

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    DOI： 10.1016/j.alit.2019.11.001

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  • Long-term treatment with clarithromycin and carbocisteine improves lung function in chronic cough patients with chronic rhinosinusitis Reviewed International journal

    Shin Kariya, Mitsuhiro Okano, Takaya Higaki, Seiichiro Makihara, Tomoyasu Tachibana, Kazunori Nishizaki

    AMERICAN JOURNAL OF OTOLARYNGOLOGY   41 ( 1 )   102315 - 102315   2020.1

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    DOI： 10.1016/j.amjoto.2019.102315

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  • False vocal cord perforation with abscess treated by negative pressure wound therapy. Reviewed International journal

    Seiichiro Makihara, Shin Kariya, Tomoyuki Naito, Kensuke Uraguchi, Junya Matsumoto, Yohei Noda, Mitsuhiro Okano, Kazunori Nishizaki

    SAGE open medical case reports   8   2050313X20915415   2020

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    DOI： 10.1177/2050313X20915415

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  • Methotrexate-associated lymphoproliferative disorder with multiple pulmonary nodules and bilateral cervical lymphadenopathy. Reviewed International journal

    Seiichiro Makihara, Shin Kariya, Mai Noujima-Harada, Nobuya Ohara, Tomoyuki Naito, Junya Matsumoto, Yohei Noda, Mitsuhiro Okano, Tadashi Yoshino, Kazunori Nishizaki

    Auris, nasus, larynx   46 ( 6 )   927 - 933   2019.12

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    DOI： 10.1016/j.anl.2019.01.010

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  • Attachment-oriented endoscopic surgical management for inverted papillomas in the nasal cavity and paranasal sinuses. Reviewed International journal

    Seiichiro Makihara, Shin Kariya, Tomoyuki Naito, Kensuke Uraguchi, Junya Matsumoto, Yohei Noda, Mitsuhiro Okano, Kazunori Nishizaki

    Auris, nasus, larynx   46 ( 5 )   748 - 753   2019.10

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    DOI： 10.1016/j.anl.2019.02.007

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  • 非定型悪性外耳道炎の2例 Reviewed

    牧原 靖一郎, 假谷 伸, 内藤 智之, 松本 淳也, 石原 久司, 岡野 光博, 西崎 和則

    耳鼻咽喉科・頭頸部外科   91 ( 7 )   594 - 599   2019.6

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  • 鼻副鼻腔血瘤腫の3例 Reviewed

    牧原 靖一郎, 内藤 智之, 浦口 健介, 松本 淳也, 假谷 伸, 岡野 光博, 西崎 和則

    耳鼻咽喉科・頭頸部外科   91 ( 7 )   588 - 593   2019.6

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  • Dangerous noodle: A case of swallowing syncope and a review of 122 cases from the literature. Reviewed

    Kensuke Uraguchi, Shin Kariya, Seiichiro Makihara, Aiko Oka, Hiroo Ueeda, Yohei Noda, Kazunori Nishizaki

    Journal of arrhythmia   35 ( 1 )   145 - 148   2019.2

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  • Determining an Appropriate Time to Start Prophylactic Treatment with Intranasal Corticosteroids in Japanese Cedar Pollinosis Reviewed International journal

    Takenori Haruna, Shin Kariya, Takaya Higaki, Sei-ichiro Makihara, Kengo Kanai, Yasutoshi Komatsubara, Aiko Oka, Kazunori Nishizaki, Mitsuhiro Okano

    Medical Sciences   7 ( 1 )   2019.1

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    : Prophylactic treatment with intranasal corticosteroids is effective for pollen-induced seasonal allergic rhinitis. However, the appropriate time to start this treatment remains unclear. We performed a double-blinded, randomized, placebo-controlled trial. Starting on February 1, 2014, patients with Japanese cedar pollinosis received either fluticasone furoate nasal spray (FFNS) for 8 weeks (Group A: n = 24), placebo nasal spray for 2 weeks followed by FFNS for 6 weeks (Group B: n = 23), or placebo for 4 weeks followed by FFNS for 4 weeks (Group C: n = 23). The primary endpoint was comparison of the total naso-ocular symptom score (TSS). Secondary endpoints including the increment cost effective ratio (ICER) were also determined. Continuous pollen dispersion began on the 24th of February. Therefore, Group A and Group B received 3-weeks and 1-week of prophylactic treatment, respectively, whereas Group C received post-onset treatment. During the peak pollen-dispersal period, significant differences in TSS were seen between the groups, particularly between Group A and C. The ICER of Group B vs. Group C was lower than that of Group A vs. Group C. These results suggest that long-term prophylactic treatment with FFNS is clinically the most potent treatment, whereas short-term prophylactic treatment is cost effective for pollen-induced allergic rhinitis.

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  • The Relationship Between the Width of the Frontal Recess and the Frontal Recess Cells in Japanese Patients. Reviewed International journal

    Seiichiro Makihara, Shin Kariya, Mitsuhiro Okano, Tomoyuki Naito, Kensuke Uraguchi, Junya Matsumoto, Yohei Noda, Kazunori Nishizaki

    Clinical medicine insights. Ear, nose and throat   12   1179550619884946 - 1179550619884946   2019

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    OBJECTIVE: The agger nasi cell (ANC) is an easily identifiable landmark when approaching the frontal sinus. The success of endoscopic frontal sinus surgery may be influenced by the width of the frontal recess (FR). The aim of this study is to examine the relationship between the FR width and the ANC size in Japanese patients. In addition, the effect of various frontal recess cells (FRCs) on the development of frontal sinusitis has been examined. MATERIALS AND METHODS: Multiplanar computed tomography (CT) scans of the nasal cavities and paranasal sinuses in 95 patients (190 sides) before endoscopic sinus surgery were reviewed. The presence of FRCs, the thickness of the frontal beak (FB), the ANC size, and the anterior-to-posterior (A-P) length of the frontal isthmus (FI) and FR were evaluated in patients with and without frontal sinusitis. RESULTS: The prevalence of the ANC, frontal cell types 1, 2, 3, and 4, frontal bullar cell (FBC), suprabullar cell, supraorbital ethmoid cell, and interfrontal sinus septal cell was 85.3%, 11.6%, 0%, 7.9%, 0%, 25.3%, 45.8%, 16.8%, and 15.3%, respectively. The ANC volume showed a significant positive correlation with the A-P length of the FI and FR. The incidence of frontal sinusitis in the patients with FBCs was significantly higher than that without FBCs. CONCLUSION: A large ANC offers a greater potential to facilitating the approach to the frontal sinus because of the extensiveness of the FR in Japanese patients. The presence of FBCs may be related to a higher incidence of frontal sinusitis.

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  • Low Incidence of Allergic Fungal Rhinosinusitis in Japanese Patients. Reviewed International journal

    Seiichiro Makihara, Shin Kariya, Tomoyuki Naito, Junya Matsumoto, Mitsuhiro Okano, Kazunori Nishizaki

    Clinical medicine insights. Ear, nose and throat   12   1179550619870758 - 1179550619870758   2019

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    BACKGROUND: Allergic fungal rhinosinusitis (AFRS) is a noninvasive fungal disease of the sinuses with a very high recurrence rate. A very small number of Japanese cases have been reported. MATERIAL AND METHODS: The subjects were 6 patients with AFRS out of 429 patients who underwent endoscopic sinus surgery at Kagawa Rosai Hospital between December 2011 and November 2017. We retrospectively examined the clinical features and outcomes of these 6 patients. RESULTS: The incidence of AFRS was 1.4% (6/429). Allergic fungal rhinosinusitis was unilateral in 5 cases and bilateral in 1. Computed tomography revealed hyperdense areas representing allergic mucin, but no patient exhibited bone erosion. Magnetic resonance imaging showed hypointense or no signal regions at the locations of allergic mucin. Postoperatively, 1 patient developed recurrence. Because the recurrent patient had no significant symptoms, he refused further surgery and received drug therapy. Preoperative eosinophil counts and total IgE levels were elevated in all patients; postoperatively, both remained high in the patient who developed recurrence. Postoperative treatments included steroid therapy and nasal irrigation. CONCLUSIONS: Allergic fungal rhinosinusitis is less prevalent in Japan than in Western nations. Peripheral blood eosinophil and serum IgE values may be used as the biomarkers. SIGNIFICANCE: Allergic fungal rhinosinusitis is prone to recurrence. Postoperative treatment including steroid therapy is important in the management of AFRS.

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  • Impact of Preoperative Systemic Corticosteroids on the Histology and Diagnosis of Eosinophilic Chronic Rhinosinusitis. Reviewed International journal

    Kosuke Akiyama, Seiichiro Makihara, Kensuke Uraguchi, Yasushi Samukawa, Aiko Oka, Hiroshi Hoshikawa

    International archives of allergy and immunology   179 ( 2 )   81 - 88   2019

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    DOI： 10.1159/000496437

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  • Utility of the axillary flap approach to the frontal recess in patients with chronic rhinosinusitis Reviewed

    Seiichiro Makihara, Shin Kariya, Mitsuhiro Okano, Tomoyuki Naito, Kensuke Uraguchi, Junya Matsumoto, Kazunori Nishizaki

    Otorinolaringologia   69 ( 3 )   135 - 140   2019

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    DOI： 10.23736/S0392-6621.19.02224-0

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  • The examination of ige and peripheral blood mononuclear cells responses to flour extracts in a baker's rhinitis patient Reviewed

    Takenori Haruna, Mitsuhiro Okano, Tazuko Fujiwara, Takaya Higaki, Shin Kariya, Seiichiro Makihara, Kengo Kanai, Tomoyasu Tachibana, Yuko Matsuyama, Yasutoshi Komatsubara, Yuto Naoi, Kazunori Nishizaki

    Japanese Journal of Allergology   68 ( 1 )   35 - 42   2019

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  • NLRP3 inflammasome expression in lipopolysaccharide-induced otitis media. Reviewed International journal

    Shin Kariya, Mitsuhiro Okano, Pengfei Zhao, Yukihide Maeda, Yuko Kataoka, Takaya Higaki, Yohei Noda, Seiichiro Makihara, Kazunori Nishizaki

    Acta oto-laryngologica   138 ( 12 )   1061 - 1065   2018.12

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    DOI： 10.1080/00016489.2018.1515499

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  • 【私はこうしている-鼻科手術編】鼻科手術全般 鼻科手術のための局所解剖 鼻副鼻腔

    岡野 光博, 牧原 靖一郎

    JOHNS   34 ( 9 )   1083 - 1085   2018.9

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  • 【私はこうしている-鼻科手術編】各種疾患に対する手術 副鼻腔真菌症

    牧原 靖一郎, 岡野 光博

    JOHNS   34 ( 9 )   1269 - 1272   2018.9

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  • Glottic cancer in patients without complaints of hoarseness. International journal

    Tomoyasu Tachibana, Yorihisa Orita, Hidenori Marunaka, Seiichiro Makihara, Misato Hirai, Kentaro Miki, Yuya Ogawara, Hisashi Ishihara, Yuko Matsuyama, Iku Abe-Fujisawa, Aiko Shimizu, Yasuharu Sato, Kazunori Nishizaki

    Head & neck   40 ( 7 )   1608 - 1608   2018.7

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    DOI： 10.1002/hed.25196

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  • Association between impaired IL-10 production following exposure to Staphylococcus aureus enterotoxin B and disease severity in eosinophilic chronic rhinosinusitis. Reviewed International journal

    Takenori Haruna, Shin Kariya, Tazuko Fujiwara, Takaya Higaki, Seiichiro Makihara, Kengo Kanai, Rumi Fujiwara, Satoshi Iwasaki, Yoshihiro Noguchi, Kazunori Nishizaki, Mitsuhiro Okano

    Allergology international : official journal of the Japanese Society of Allergology   67 ( 3 )   392 - 398   2018.7

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    DOI： 10.1016/j.alit.2018.02.001

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  • 内視鏡手術で摘出した蝶形骨洞線維性骨異形成症例 Reviewed

    浦口 健介, 牧原 靖一郎, 内藤 智之, 假谷 伸, 中川 隆之, 岡野 光博, 西崎 和則

    日本鼻科学会会誌   57 ( 2 )   138 - 144   2018.7

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  • Neck metastasis in patients with T1-2 supraglottic cancer Reviewed

    Tomoyasu Tachibana, Yorihisa Orita, Hidenori Marunaka, Sei ichiro Makihara, Misato Hirai, Yuka Gion, Kana Ikegami, Kentaro Miki, Takuma Makino, Yasuyuki Noyama, Yasutoshi Komatsubara, Miyuki Kimura, Tadashi Yoshino, Kazunori Nishizaki, Yasuharu Sato

    Auris Nasus Larynx   45 ( 3 )   540 - 545   2018.6

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    DOI： 10.1016/j.anl.2017.06.002

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  • Pulmonary function in patients with eosinophilic chronic rhinosinusitis. Reviewed International journal

    Kensuke Uraguchi, Shin Kariya, Seiichiro Makihara, Mitsuhiro Okano, Takenori Haruna, Aiko Oka, Rumi Fujiwara, Yohei Noda, Kazunori Nishizaki

    Auris, nasus, larynx   45 ( 3 )   476 - 481   2018.6

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    DOI： 10.1016/j.anl.2017.07.020

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  • Laryngeal squamous cell papilloma is highly associated with human papillomavirus. Reviewed International journal

    Yorihisa Orita, Yuka Gion, Tomoyasu Tachibana, Kana Ikegami, Hidenori Marunaka, Seiichiro Makihara, Yasuhiko Yamashita, Kentaro Miki, Takuma Makino, Naoki Akisada, Yusuke Akagi, Miyuki Kimura, Tadashi Yoshino, Kazunori Nishizaki, Yasuharu Sato

    Japanese journal of clinical oncology   48 ( 4 )   350 - 355   2018.4

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    DOI： 10.1093/jjco/hyy009

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  • 前頭洞・蝶形骨洞に同時に発見された副鼻腔真菌症例 Reviewed

    浦口 健介, 牧原 靖一郎, 内藤 智之, 岡 愛子, 假谷 伸, 岡野 光博, 西崎 和則

    日本鼻科学会会誌   56 ( 4 )   625 - 631   2017.12

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  • 意識障害を契機に発見された前頭洞型髄膜脳瘤例 Reviewed

    假谷 伸, 岡野 光博, 檜垣 貴哉, 春名 威範, 牧原 靖一郎, 大道 亮太郎, 西崎 和則

    日本鼻科学会会誌   56 ( 4 )   564 - 569   2017.12

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  • 扁桃周囲膿瘍のCT所見と臨床経過 Reviewed

    岡 愛子, 牧原 靖一郎

    日本気管食道科学会会報   68 ( 3 )   217 - 221   2017.6

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  • Delayed esophageal perforation 17 years after anterior cervical fusion surgery with plating. Reviewed

    Hisanori Ikuma, Katsuhiko Ishibashi, Kazuta Yamashita, Ryoji Joko, Seiichiro Makihara, Masahiko Kobayashi, Yoshiki Yokoyama

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association   22 ( 3 )   566 - 570   2017.5

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    DOI： 10.1016/j.jos.2015.09.001

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  • 【花粉症研究の進歩】鼻噴霧ステロイドの効果的な使い方の研究

    春名 威範, 岡野 光博, 檜垣 貴哉, 牧原 靖一郎

    アレルギー・免疫   24 ( 3 )   328 - 333   2017.2

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  • IL-22/IL-22R1 signaling regulates the pathophysiology of chronic rhinosinusitis with nasal polyps via alteration of MUC1 expression Reviewed

    Yasuyuki Noyama, Mitsuhiro Okano, Tazuko Fujiwara, Shin Kariya, Takaya Higaki, Takenori Haruna, Sei ichiro Makihara, Kengo Kanai, Takahisa Koyama, Masami Taniguchi, Jun ichi Ishitoya, Akira Kanda, Yoshiki Kobayashi, Mikiya Asako, Koichi Tomoda, Kazunori Nishizaki

    Allergology International   66 ( 1 )   42 - 51   2017.1

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    DOI： 10.1016/j.alit.2016.04.017

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  • Evaluation of a New and Simple Classification for Endoscopic Sinus Surgery Reviewed

    Kengo Kanai, Mitsuhiro Okano, Takenori Haruna, Takaya Higaki, Ryotaro Omichi, Sei Ichiro Makihara, Munechika Tsumura, Shin Kariya, Yuji Hirata, Kazunori Nishizaki

    Allergy and Rhinology   8 ( 3 )   2017

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    DOI： 10.2500/ar.2017.8.0208

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  • 眼窩骨膜下膿瘍を合併したビスフォスフォネート関連顎骨壊死症例 Reviewed

    牧原 靖一郎, 岡野 光博, 浦口 健介, 岡 愛子, 假谷 伸, 西崎 和則

    日本鼻科学会会誌   55 ( 4 )   515 - 523   2016.12

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  • Effect of prostaglandin D2 on VEGF release by nasal polyp fibroblasts Reviewed

    Kengo Kanai, Mitsuhiro Okano, Tazuko Fujiwara, Shin Kariya, Takenori Haruna, Ryotaro Omichi, Sei ichiro Makihara, Yuji Hirata, Kazunori Nishizaki

    Allergology International   65 ( 4 )   414 - 419   2016.10

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    DOI： 10.1016/j.alit.2016.03.003

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  • A Study of Cases of Brainstem/cerebellar Infarction Detected as False Negatives by Initial MRI. Reviewed

    Kensuke Uraguchi, Shin Kariya, Aiko Oka, Munetika Tsumura, Hisashi Ishihara, Tomomi Miyatake, Yuji Hirata, Seiichiro Makihara, Kazunori Nishizaki

    Nihon Jibiinkoka Gakkai kaiho   119 ( 10 )   1290 - 9   2016.10

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  • 頸部放射線治療後に喉頭壊死を起こした2症例 Reviewed

    岡 愛子, 森 照茂, 牧原 靖一郎

    日本気管食道科学会会報   67 ( 4 )   283 - 288   2016.8

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  • Effect of intranasal corticosteroid on pre-onset activation of eosinophils and mast cells in experimental Japanese cedar pollinosis Reviewed

    Yasuyuki Noyama, Mitsuhiro Okano, Tazuko Fujiwara, Shin Kariya, Sei ichiro Makihara, Takenori Haruna, Kengo Kanai, Takaya Higaki, Kazunori Nishizaki

    Allergology International   65 ( 3 )   259 - 265   2016.7

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    DOI： 10.1016/j.alit.2015.12.007

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  • 内視鏡下鼻内手術を施行した巨大な鼻口蓋管嚢胞例 Reviewed

    牧原 靖一郎, 浦口 健介, 岡 愛子, 石原 久司, 宮武 智実, 假谷 伸, 岡野 光博, 西崎 和則

    耳鼻咽喉科・頭頸部外科   88 ( 7 )   525 - 530   2016.6

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  • 内視鏡下副鼻腔手術を施行した好酸球性副鼻腔炎症例の検討 Reviewed

    牧原 靖一郎, 浦口 健介, 岡 愛子, 石原 久司, 宮武 智実, 假谷 伸, 岡野 光博, 西崎 和則

    耳鼻咽喉科・頭頸部外科   88 ( 6 )   429 - 433   2016.5

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  • Glottic cancer in patients without complaints of hoarseness. Reviewed International journal

    Tomoyasu Tachibana, Yorihisa Orita, Hidenori Marunaka, Seiichiro Makihara, Misato Hirai, Kentaro Miki, Yuya Ogawara, Hisashi Ishihara, Yuko Matsuyama, Iku Abe-Fujisawa, Aiko Shimizu, Yasuharu Sato, Kazunori Nishizaki

    Head & neck   38 Suppl 1   E316-20 - E320   2016.4

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  • Regulatory effect of TLR3 signaling on staphylococcal enterotoxin-induced IL-5, IL-13, IL-17A and IFN-γ production in chronic rhinosinusitis with nasal polyps Reviewed

    Mitsuhiro Okano, Tazuko Fujiwara, Shin Kariya, Takaya Higaki, Sei Ichiro Makihara, Takenori Haruna, Yasuyuki Noyama, Takahisa Koyama, Ryotaro Omichi, Yorihisa Orita, Kentaro Miki, Kengo Kanai, Kazunori Nishizaki

    Allergology International   65 ( 1 )   96 - 102   2016.1

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  • Staphylococcal protein A-formulated immune complexes suppress enterotoxin-induced cellular responses in nasal polyps Reviewed

    Mitsuhiro Okano, Tazuko Fujiwara, Shin Kariya, Takenori Haruna, Takaya Higaki, Yasuyuki Noyama, Sei Ichiro Makihara, Kengo Kanai, Kazunori Nishizaki

    Journal of Allergy and Clinical Immunology   136 ( 2 )   343 - 350.e8   2015.8

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  • 【これからのアレルギー性鼻炎対策】新しい全噴霧用ステロイド薬の使い方

    春名 威範, 岡野 光博, 檜垣 貴哉, 牧原 靖一郎, 野山 和廉

    ENTONI   ( 180 )   37 - 42   2015.5

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  • 急性リンパ性白血病の寛解導入療法中に発症した鼻脳型ムーコル症例 Reviewed

    牧原 靖一郎, 石原 久司, 宮武 智実, 津村 宗近, 野田 洋平, 檜垣 貴哉, 假谷 伸, 岡野 光博, 西崎 和則

    日本鼻科学会会誌   54 ( 1 )   31 - 37   2015.5

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  • ガイドライン 耳鼻科シリーズ 鼻アレルギー診療ガイドライン 通年性鼻炎と花粉症

    牧原 靖一郎, 岡野 光博

    岡山医学会雑誌   127 ( 1 )   55 - 57   2015.4

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  • NSAIDsにシメチジン追加後早期に疼痛が改善した石灰沈着性頸長筋腱炎例 Reviewed

    石原 久司, 牧原 靖一郎, 宮武 智実, 津村 宗近, 假谷 伸

    耳鼻咽喉科臨床   108 ( 3 )   243 - 247   2015.3

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  • How long should we continue S-1 as adjuvant chemotherapy for squamous cell carcinoma of the head and neck? Reviewed International journal

    Misato Hirai, Yorihisa Orita, Soshi Takao, Tomoyasu Tachibana, Hidenori Marunaka, Seiichiro Makihara, Kentaro Miki, Yasuyuki Noyama, Sayaka Fuji, Akiko Torigoe, Yasuharu Sato, Kazunori Nishizaki

    Acta oto-laryngologica   135 ( 10 )   1079 - 85   2015

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  • Cellular responses to Staphylococcus aureus alpha-toxin in chronic rhinosinusitis with nasal polyps. Reviewed International journal

    Mitsuhiro Okano, Tazuko Fujiwara, Shin Kariya, Takaya Higaki, Takenori Haruna, Osamu Matsushita, Yohei Noda, Seiichiro Makihara, Kengo Kanai, Yasuyuki Noyama, Masami Taniguchi, Kazunori Nishizaki

    Allergology international : official journal of the Japanese Society of Allergology   63 ( 4 )   563 - 73   2014.12

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  • Endoscopic modified Lothrop procedureが有用であった前頭陥凹骨腫例 Reviewed

    牧原 靖一郎, 石原 久司, 宮武 智実, 小林 正佳, 假谷 伸, 岡野 光博, 西崎 和則

    日本鼻科学会会誌   53 ( 4 )   542 - 546   2014.12

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  • 眼窩骨膜内に膿瘍形成を認めた例 Reviewed

    牧原 靖一郎, 石原 久司, 宮武 智実, 唐木 將行, 津村 宗近, 假谷 伸, 岡野 光博, 西崎 和則

    日本鼻科学会会誌   53 ( 4 )   506 - 512   2014.12

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  • 当院での下垂体部腫瘍に対する内視鏡下経鼻下垂体手術

    平下 浩司, 畝田 篤仁, 松本 淳志, 大久保 修一, 柚木 正敏, 吉野 公博, 牧原 靖一郎

    香川労災病院雑誌   ( 20 )   15 - 18   2014.11

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  • 当院における外来化学療法室の現状と課題

    滝本 秀隆, 坂本 路代, 山崎 美佐, 土佐 直子, 亀井 美紀, 横山 智美, 能願 美由紀, 中尾 三千代, 乃一 真由美, 永田 拓也, 井上 秀幸, 木村 圭吾, 村岡 篤, 平下 浩司, 牧原 靖一郎, 水野 全裕, 川田 昭徳, 香川労災病院化学療法委員会

    香川労災病院雑誌   ( 20 )   1 - 4   2014.11

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  • 浸潤型蝶形骨洞アスペルギルス症に対して蝶形骨洞単洞化手術を施行した1例 Reviewed

    牧原 靖一郎, 岡野 光博, 石原 久司, 宮武 智実, 津村 宗近, 假谷 伸, 西崎 和則

    耳鼻咽喉科・頭頸部外科   86 ( 9 )   765 - 770   2014.8

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  • Local expression of interleukin-17a is correlated with nasal eosinophilia and clinical severity in allergic rhinitis. Reviewed International journal

    Seiichiro Makihara, Mitsuhiro Okano, Tazuko Fujiwara, Yohei Noda, Takaya Higaki, Tomomi Miyateke, Kengo Kanai, Takenori Haruna, Shin Kariya, Kazunori Nishizaki

    Allergy & rhinology (Providence, R.I.)   5 ( 1 )   22 - 7   2014.4

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  • Pulmonary function in patients with chronic rhinosinusitis and allergic rhinitis Reviewed

    S. Kariya, M. Okano, T. Oto, T. Higaki, S. Makihara, T. Haruna, K. Nishizaki

    Journal of Laryngology and Otology   128 ( 3 )   255 - 262   2014.3

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  • 【スギ花粉症の発症と初期治療】鼻噴霧ステロイド薬を用いた初期治療の有効性

    小山 貴久, 岡野 光博, 春名 威範, 野山 和廉, 假谷 伸, 檜垣 貴哉, 牧原 靖一郎, 西崎 和則

    臨床免疫・アレルギー科   60 ( 6 )   664 - 667   2013.12

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  • 当院における外来化学療法室の現状と課題

    滝本 秀隆, 坂本 路代, 藤浦 美佐, 土佐 直子, 亀井 美紀, 能願 美由紀, 中尾 三千代, 乃一 真由美, 香川 秀子, 永田 拓也, 井上 秀幸, 木村 圭吾, 村岡 篤, 平下 浩司, 牧原 靖一郎, 水野 全裕, 川田 昭徳, 香川労災病院化学療法委員会

    香川労災病院雑誌   ( 19 )   1 - 5   2013.10

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  • 鼻出血を契機に発見された鼻腔原発のglomangiopericytomaの1例 Reviewed

    大道 亮太郎, 假谷 伸, 岡野 光博, 牧原 靖一郎, 小野田 友男, 江口 元治, 西崎 和則

    頭頸部外科   23 ( 2 )   141 - 144   2013.10

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  • Neutralizing antibody against granulocyte/macrophage colony-stimulating factor inhibits inflammatory response in experimental otitis media. Reviewed International journal

    Shin Kariya, Mitsuhiro Okano, Takaya Higaki, Seiichiro Makihara, Takenori Haruna, Motoharu Eguchi, Kazunori Nishizaki

    The Laryngoscope   123 ( 6 )   1514 - 8   2013.6

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    DOI： 10.1002/lary.23795

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  • 鼻中隔膿瘍を伴った浸潤型蝶形骨洞アスペルギルス症例 Reviewed

    牧原 靖一郎, 竹内 彩子, 山本 美紀, 妹尾 一範, 赤木 成子, 福本 晶, 津村 宗近, 石原 久司, 假谷 伸, 岡野 光博, 西崎 和則

    耳鼻咽喉科臨床   106 ( 3 )   213 - 220   2013.3

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  • Characterization of IL-18 expression and release in the pathogenesis of chronic rhinosinusitis. Reviewed International journal

    Mitsuhiro Okano, Tazuko Fujiwara, Seiichiro Makihara, Rumi Fujiwara, Takaya Higaki, Shin Kariya, Yohei Noda, Takenori Haruna, Kazunori Nishizaki

    International archives of allergy and immunology   160 ( 3 )   275 - 86   2013

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    DOI： 10.1159/000341668

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  • Early interventional treatment with intranasal corticosteroids compared with postonset treatment in pollinosis. Reviewed International journal

    Takaya Higaki, Mitsuhiro Okano, Seiichiro Makihara, Tazuko Fujiwara, Takenori Haruna, Yohei Noda, Shin Kariya, Kazunori Nishizaki

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology   109 ( 6 )   458 - 64   2012.12

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    DOI： 10.1016/j.anai.2012.08.016

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  • Roles of IL-17, Th1, and Tc1 cells in patients with IgG4-related sclerosing sialadenitis. Reviewed International journal

    Nobuo Ohta, Seiichiro Makihara, Mitsuhiro Okano, Kazuya Kurakami, Akihiro Ishida, Takatoshi Furukawa, Yusuke Suzuki, Tomoo Watanabe, Seiji Kakehata, Masaru Aoyagi

    The Laryngoscope   122 ( 10 )   2169 - 74   2012.10

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    DOI： 10.1002/lary.23429

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  • COX/PGE<inf>2</inf> axis critically regulates effects of LPS on eosinophilia-associated cytokine production in nasal polyps Reviewed

    T. Higaki, M. Okano, T. Fujiwara, S. Makihara, S. Kariya, Y. Noda, T. Haruna, K. Nishizaki

    Clinical and Experimental Allergy   42 ( 8 )   1217 - 1226   2012.8

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1365-2222.2012.04015.x

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  • 滲出性中耳炎を合併した翼口蓋窩嚢胞例 Reviewed

    牧原 靖一郎, 岡野 光博, 折田 頼尚, 小野田 友男, 假谷 伸, 津村 宗近, 西崎 和則

    耳鼻咽喉科臨床   105 ( 7 )   631 - 636   2012.7

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  • Early interventional treatment with intranasal mometasone furoate in Japanese cedar/cypress pollinosis: a randomized placebo-controlled trial. Reviewed International journal

    Seiichiro Makihara, Mitsuhiro Okano, Tazuko Fujiwara, Masayo Kimura, Takaya Higaki, Takenori Haruna, Yohei Noda, Kengo Kanai, Shin Kariya, Kazunori Nishizaki

    Allergology international : official journal of the Japanese Society of Allergology   61 ( 2 )   295 - 304   2012.6

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    DOI： 10.2332/allergolint.11-OA-0382

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  • Lipopolysaccharide induces proinflammatory cytokines and chemokines in experimental otitis media through the prostaglandin D<inf>2</inf> receptor (DP)-dependent pathway Reviewed

    M. Eguchi, S. Kariya, M. Okano, T. Higaki, S. Makihara, T. Fujiwara, K. Nagata, H. Hirai, S. Narumiya, M. Nakamura, K. Nishizaki

    Clinical and Experimental Immunology   163 ( 2 )   260 - 269   2011.2

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1365-2249.2010.04292.x

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  • Role of fungal antigens in eosinophilia-associated cellular responses in nasal polyps: A comparison with enterotoxin Reviewed

    M. Okano, T. Fujiwara, T. Haruna, S. Kariya, S. Makihara, T. Higaki, K. Nishizaki

    Clinical and Experimental Allergy   41 ( 2 )   171 - 178   2011.2

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1365-2222.2010.03584.x

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  • Characterization of pollen antigen-induced IL-31 production by PBMCs in patients with allergic rhinitis. Reviewed International journal

    Mitsuhiro Okano, Tazuko Fujiwara, Takaya Higaki, Seiichiro Makihara, Takenori Haruna, Yohei Noda, Kengo Kanai, Shin Kariya, Hiroshi Yasueda, Kazunori Nishizaki

    The Journal of allergy and clinical immunology   127 ( 1 )   277 - 9   2011.1

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    DOI： 10.1016/j.jaci.2010.09.029

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  • 慢性上気道炎症におけるIL-17A発現の臨床的意義とその制御機構

    牧原 靖一郎, 岡野 光博, 藤原 田鶴子, 檜垣 貴哉, 野田 洋平, 假谷 伸, 西崎 和則

    耳鼻咽喉科免疫アレルギー   28 ( 3 )   217 - 222   2010.9

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  • Regulation and characterization of IL-17A expression in patients with chronic rhinosinusitis and its relationship with eosinophilic inflammation. Reviewed International journal

    Seiichiro Makihara, Mitsuhiro Okano, Tazuko Fujiwara, Shin Kariya, Yohei Noda, Takaya Higaki, Kazunori Nishizaki

    The Journal of allergy and clinical immunology   126 ( 2 )   397 - 400   2010.8

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    DOI： 10.1016/j.jaci.2010.05.014

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  • 【ステロイドによる局所療法のアップデート】新規鼻噴霧用ステロイド薬の急性鼻副鼻腔炎に対する欧米での評価

    牧原 靖一郎, 岡野 光博

    アレルギー・免疫   17 ( 4 )   591 - 598   2010.3

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    Authorship：Lead author   Language：Japanese   Publisher：(株)医薬ジャーナル社  

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  • Prostaglandin E(2) suppresses staphylococcal enterotoxin-induced eosinophilia-associated cellular responses dominantly through an E-prostanoid 2-mediated pathway in nasal polyps. Reviewed International journal

    Mitsuhiro Okano, Tazuko Fujiwara, Takenori Haruna, Shin Kariya, Seiichiro Makihara, Takaya Higaki, Kazunori Nishizaki

    The Journal of allergy and clinical immunology   123 ( 4 )   868 - 74   2009.4

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    DOI： 10.1016/j.jaci.2009.01.047

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  • A case of renal metastasis originating from primary hypopharyngeal and esophageal cancer Reviewed

    NOMIYA Shigenobu, MAKIHARA Seiichirou, MATSUMOTO Rie, ORITA Yorihisa, KARIYA Shin, ONODA Tomoo, TOMINAGA Susumu, NISHIZAKI Kazunori

    Stomato-pharyngology   20 ( 3 )   293 - 298   2008

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japan Society of Stomato-pharyngology  

    DOI： 10.14821/stomatopharyngology1989.20.293

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    Other Link： http://search.jamas.or.jp/link/ui/2008358660

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MISC

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Presentations

  • シンポジウム 4 悪性頭蓋底腫瘍の手術適応・治療適応・戦略～3科合同の開頭経鼻同時手術を用いた前頭蓋底悪性腫瘍の治療戦略

    牧原 靖一郎, 秋定 直樹, 藤本 将平, 清水 藍子, 村井 綾, 牧野 琢丸, 檜垣 貴哉, 大谷 理浩, 石田 穣治, 藤井 謙太郎, 安原 隆雄, 太田 智之, 松本 洋, 安藤 瑞生

    第36回日本頭蓋底外科学会  2024.7.5 

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    Event date： 2024.7.5 - 2024.7.6

    Presentation type：Symposium, workshop panel (public)  

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  • Pneumocephalus Resulting from Inverted Papilloma in the Frontoethmoidal Sinus: Case Report and Literature Review

    Makihara S, Ando M

    ISIAN & IRS 2024 

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    Event date： 2024.4.4 - 2024.4.6

    Presentation type：Poster presentation  

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  • ランチョンセミナー ESSにおける一歩進んだナビゲーションシステムの活用 ～術前CTプランニングとARナビゲーション使用の実際 Invited

    牧原 靖一郎

    第61回 日本鼻科学会 総会・学術講演会  2022.10.13 

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    Event date： 2022.10.13 - 2022.10.15

    Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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  • シンポジウム 内視鏡下鼻副鼻腔手術の工夫 各種エナジーデバイスを用いた術野の最適化の工夫 Invited

    牧原 靖一郎

    第61回 日本鼻科学会 総会・学術講演会  2022.10.13 

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    Event date： 2022.10.13 - 2022.10.15

    Presentation type：Symposium, workshop panel (nominated)  

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  • 教育セミナー４ 鼻中隔手術－矯正術の基本から穿孔閉鎖まで Invited

    牧原 靖一郎

    第31回日本頭頸部外科学会総会ならびに学術講演会  2022.3.4 

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    Event date： 2022.3.3 - 2022.3.4

    Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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  • シンポジウム COVID-19への対応 「感染対策共通講習」～COVID-19流行期における診察と検査 Invited

    牧原 靖一郎

    第60回日本鼻科学会総会・学術講演会 

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    Event date： 2021.9.23 - 2021.9.25

    Presentation type：Symposium, workshop panel (nominated)  

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  • International Session, Utility of the Axillary Flap Approach to the Frontal Recess and Radiological Assessment of the Anatomy of Frontal Recess Cells in Japanese Patients with Chronic Rhinosinusitis Invited

    Makihara S

    57th Korean Rhinologic Society Annual Congress in Seoul 

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    Event date： 2019.3.19 - 2019.3.20

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  • 1,25-dihydroxyvitamin D 3 levels are higher in Japanese chronic rhinosinusitis with nasal polyp patients

    Makihara S

    Rhinology World Congress – Hong Kong 2017 

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    Event date： 2017.9.1 - 2017.9.3

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  • シンポジウム 好酸球性副鼻腔炎、慢性副鼻腔炎のフェノタイプ 診断と治療、その違い－プロスタグランジン代謝からみた副鼻腔炎のフェノタイピング

    牧原 靖一郎, 岡野 光博

    第66回日本アレルギー学会学術大会 

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    Event date： 2017.6.16 - 2017.6.18

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  • ミニワークショップ 副鼻腔炎 診療・研究の進歩－慢性副鼻腔炎におけるIL-18の発現とサイトカイン産生制御作用

    牧原 靖一郎, 岡野 光博, 檜垣 貴哉, 假谷 伸, 山本 美紀, 春名 威範, 金井 健吾, 野田 洋平, 西崎 和則

    第60回日本アレルギー学会秋季学術大会 

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    Event date： 2010.11.25 - 2010.11.27

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  • シンポジウム 慢性上気道炎症におけるIL-17A発現の臨床的意義とその制御機構

    牧原 靖一郎, 岡野 光博, 檜垣 貴哉, 仮谷 伸, 金井 健吾, 松山 祐子, 西崎 和則

    第28回日本耳鼻咽喉科免疫アレルギー学会 

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    Event date： 2010.2.18 - 2010.2.20

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  • ミニシンポジウム サイトカイン/ケモカインおよび化学伝達物質2－副鼻腔炎におけるIL-17陽性細胞の発現とその臨床的意義

    牧原 靖一郎, 岡野 光博, 檜垣 貴哉, 西崎 和則

    第59回日本アレルギー学会秋季学術大会 

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    Event date： 2009.10.29 - 2009.10.31

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  • モーニング手術セミナー3. 鼻副鼻腔手術：自身の技量の現在地を見直し次のステップへ. 蝶形骨洞手術における安全なアプローチと術前プランニング Invited

    牧原靖一郎

    第87回耳鼻咽喉科臨床学会総会・学術講演会  2025.6.27 

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  • シンポジウム3. 内視鏡下鼻副鼻腔手術 －動画で学ぶ安全かつ効果的な手術操作－. 「Area management、エナジーデバイスを活用した安全かつ効果的な篩骨洞・上顎洞内視鏡下手術」 Invited

    牧原 靖一郎

    第34回日本頭頸部外科学会総会ならびに学術講演会  2025.1.30 

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  • Attachment-oriented endoscopic surgical management for inverted papillomas in the nasal cavity and paranasal sinuses

    Makihara S, Ando M

    ENDOKL2024  2024.4.26 

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  • Symposium 28. Pre Surgical Management, Preoperative CT Evaluation for Preventing Anterior Skull Base Injury in Endoscopic Sinus Surgery Invited

    Makihara S

    ISIAN & IRS 2024  2024.4.5 

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    Presentation type：Symposium, workshop panel (nominated)  

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  • パネルディスカッション1 頭頸部神経外科手術の新展開～後鼻神経切断術の新展開 Invited

    牧原 靖一郎

    第33回日本頭頸部外科学会総会ならびに学術講演会  2024.2.1 

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  • ランチョンセミナー 手術支援機器を活用した内視鏡下経鼻頭蓋底手術 Invited

    牧原 靖一郎

    第24回耳鼻咽喉科手術支援システム・ナビ研究会  2023.10.8 

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    Presentation type：Oral presentation (invited, special)  

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  • ランチョンセミナー 新型内視鏡と考える安全確実な鼻科手術～ESSから経鼻頭蓋底手術まで～ 安全な手術を行うための試みと新規4K内視鏡システム Invited

    牧原 靖一郎

    第62回 日本鼻科学会 総会・学術講演会  2023.9.29 

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    Presentation type：Oral presentation (invited, special)  

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  • ランチョンセミナー 新型内視鏡と考える安全確実な鼻科手術～ESSから経鼻頭蓋底手術まで～ 安全な手術を行うための試みと新規4K内視鏡システム Invited

    牧原 靖一郎

    第62回 日本鼻科学会 総会・学術講演会  2023.9.28 

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    Presentation type：Oral presentation (invited, special)  

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  • Underwater posterior nasal neurectomy compared to resection of peripheral branches of posterior nerve in severe allergic rhinitis

    Seiichiro Makihara, Mitsuhiro Okano, Kensuke Uraguchi, Aiko Shimizu, Aya Murai, Takaya Higak, Aiko Oka, Kengo Kanai, Shin Kariya, Mizuo Ando

    ERS2023  2023.6.19 

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  • Orbital complications of paranasal sinus diseases

    Makihara S

    ENT Conference of Preah Ang Duong Hospital, Phnom Penh, Cambodia  2019 

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  • The Axillary Flap Approach to the Frontal Recess of Japanese patients

    Makihara S

    ENT Conference of Preah Ang Duong Hospital, Phnom Penh, Cambodia  2017 

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  • The relationship of the width of the frontal recess and the frontal recess cells in the preoperative CT

    Makihara S, Okano M, Nishizaki K

    ERS-ISIAN-IRS 2016 Congress, Stockholm, Sweden  2016 

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  • The relationship of the frontal sinus drainage pathway and the frontal recess cells

    Makihara S, Okano M, Nishizaki K

    16th World Congress of Rhinology, Sao Paolo, Brazil  2015 

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  • Regulation and characterization of IL-17A expression in chronic rhinosinusitis and its relationship with eosinophilic inflammation

    Makihara S, Okano M, Nishizaki K

    ERS＆ISIAN 2010, Geneva, Switzerland  2010 

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  • Allergen-specific immunotherapy alters the expression of BTLA, a co-inhibitory molecule, in allergic rhinitis

    Makihara S, Okano M, Nishizaki K

    Rhinology World 2009, Philadelphia, USA  2009 

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Awards

  • Reviewer Award 2024, Auris Nasus Larynx

    2025.1   Japanese Society of Otorhinolarynglogy-Head and Neck Surgery  

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  • 令和6（2024）年度 日本頭蓋底外科学会優秀論文賞

    2025   日本頭蓋底外科学会  

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  • TRS International Advanced Sinus Dissection Course 日本鼻科学会トラベルグラント

    2024  

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  • 令和5年度 サノフィ優秀論文賞（Allergology International誌部門）

    2023.4  

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Research Projects

  • 医学生に対する鼻内内視鏡手術シミュレーション教育の有用性の検討

    2025 - 2026

    公益財団法人医学教育振興財団  医学教育研究助成(令和7年度)  医学教育研究助成

    牧原 靖一郎, 村井 綾, 清水 藍子, 野田 実里

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  • ヒノキ科花粉症に対する次世代アレルゲン免疫療法の開発

    2024 - 2026

    日本医療研究開発機構  免疫アレルギー疾患実用化研究事業  実用化研究

    牧原 靖一郎

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  • ブタとヒツジ頭部を用いた内視鏡下鼻副鼻腔・頭蓋底手術トレーニングモデル

    2024 - 2025

    公益財団法人岡山医学振興会  2024年度医学教育助成  医学教育助成

    牧原 靖一郎, 大谷 理浩

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  • IL-17Aとタイプ2炎症のクロストークを標的とした難治性副鼻腔炎の新規治療戦略の確立

    2024 - 2025

    日本耳鼻咽喉科頭頸部外科学会/サノフィ株式会社  令和6年度サノフィ研究助成  サノフィ研究助成

    牧原 靖一郎, 岡野 光博, 村井 綾, 清水 藍子, 野田 実里

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  • 高温生理食塩水を用いた内視鏡洗浄による術中止血術 二重盲検無作為化比較試験

    2022 - 2023

    公益財団法人 内視鏡医学研究振興財団  令和4年度研究助成  研究助成(B)

    牧原 靖一郎, 浦口 健介, 假谷 伸, 檜垣 貴哉

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Class subject in charge

  • Otolaryngology （2024academic year） Second semester  - 木3

  • Otolaryngology （2023academic year） Second semester  - 木3

 

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