Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVE: Swimming is one of the most popular extracurricular activities for school-aged children in Japan, but its potential impact on the development of rhinitis has been debated. This study aimed to investigate the relationship between swimming lessons and rhinitis onset in school-aged children. METHODS: We used the data from the "Longitudinal Survey of Babies in the 21st Century," a nationwide prospective birth cohort of 43,767 children born in Japan between May 10 and 24, 2010. We included follow-up surveys until the children were 9 years old, focusing on swimming lesson participation and rhinitis onset. Children were grouped based on swimming lesson frequency, and rhinitis was identified through parental reports. Poisson regression and generalized estimating equation (GEE) model were used for statistical analysis. RESULTS: Swimming lessons and rhinitis showed a notable association in 18,150 children evaluated. The occasional and consistent swimming groups had increased rhinitis (adjusted risk ratio [aRR] = 1.11; 95 % confidence interval (CI), 1.02-1.22; aRR = 1.16; 95 % CI, 1.09-1.23), respectively. The GEE models were consistent with these findings, demonstrating the population average effects across repeated measures data (aRR = 1.13; 95 % CI, 1.08-1.18). CONCLUSION: This study found that swimming lessons may increase the risk of rhinitis in children, highlighting the need to reevaluate their implications for child health.

DOI： 10.1016/j.ijporl.2025.112415

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Language：Japanese   Publisher：(株)医学書院  

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

Pediatric sinonasal tumors are rare, and minimally invasive approaches are preferred because of unknown long-term effects on development. We report three cases of highly vascular pediatric sinonasal and pterygopalatine fossa tumors that were successfully removed using an endonasal endoscopic approach with transcatheter arterial embolization (TAE). The patients (9-11 years old) had contrast-enhanced tumors in the left ethmoid sinus near the sphenopalatine foramen in case 1, in the right nasal cavity near the sphenopalatine foramen in case 2, and in the right pterygopalatine fossa in case 3, with diameters of 32, 50, and 61 mm, respectively. Computed tomography and magnetic resonance imaging demonstrated tumors with strong contrast enhancement and flow voids in all cases. TAE was performed in all cases on the day of surgery, followed by endoscopic sinus surgery with nasal septal modification. Pathology revealed pyogenic granuloma, nasal polyps, and juvenile angiofibroma. After TAE, tumor reduction improved visualization in case 1. Nasal septum manipulation enabled medial traction and tumor base identification in cases 2 and 3. The combination of preoperative TAE and septal modification proved effective for achieving complete endoscopic tumor removal. No complications occurred, and follow-up at 1-1.5 years showed no tumor recurrence or developmental abnormalities.

DOI： 10.1016/j.anl.2025.04.006

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Language：Japanese   Publisher：(株)医学書院  

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PURPOSE: Craniopharyngiomas are histologically benign tumors, but their proximity to vital neurovascular structures can significantly deteriorate functional prognoses and severely restrict patients' social interaction and activity. We retrospectively identified risk factors related to the functional prognoses in patients with craniopharyngioma treated at our center. METHODS: A retrospective analysis was conducted on 40 patients who underwent surgery for craniopharyngioma and follow-up at our institution between 2003 and 2022. Functional prognoses were evaluated in terms of obesity (body mass index [BMI] ≥ 25 for adults, BMI-Z ≥ 1.65 for children), visual function, endocrine function, and social participation. We investigated whether patient characteristics, tumor size, tumor location, hypothalamic involvement, surgical hypothalamic damage, extent of resection, and recurrence rate correlated with these functional prognostic factors. RESULTS: The median age at diagnosis was 28.0 years, with a median follow-up of 80.5 months. Postoperative obesity was present in 22 patients, and those with postoperative obesity had a significantly higher preoperative BMI or BMI-Z (preoperative BMI for adults: p = 0.074; preoperative BMI-Z for children: p = 0.020) and were significantly correlated with preoperative hypothalamic involvement grade 2 (p = 0.012) and surgical hypothalamic damage grade II (p = 0.0001). Deterioration in social participation was significantly associated with a larger tumor size (p = 0.023) and tumor recurrence (p = 0.0047). CONCLUSIONS: Patients with higher preoperative BMI or BMI-Z and hypothalamic involvement have a greater risk of postoperative obesity, and larger tumor size and recurrence can significantly deteriorate the rate of patients' social participation.

DOI： 10.1007/s11060-024-04925-7

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Language：English   Publishing type：Research paper (scientific journal)  

INTRODUCTION: Gastroesophageal reflux disease (GERD) is characterized by esophageal mucosal injury due to the reflux of gastroduodenal contents. Typical symptoms include heartburn and acid regurgitation. In addition, gastroesophageal reflux (GER) can influence conditions such as otitis media, rhinitis, and asthma. This study aimed to examine the association between dinner-to-bed time and GER-related diseases, such as otitis media, allergic rhinitis, and asthma. METHODS: This was a longitudinal cohort study using secondary data. Data were collected from a large-scale birth cohort study conducted in Japan including babies born in 2001 and 2010. Dinner-to-bed time was categorized as "longer dinner-to-bed time" (>120 minutes), "shorter dinner-to-bed time" (≤120 minutes or less), and "irregular dinner-to-bed time." Modified Poisson regression with robust variance was used to estimate risk ratios (RRs). RESULTS: A total of 60,392 children were included in this study. Children with shorter dinner-to-bed time had a higher risk of asthma (adjusted RR (aRR) = 1.10; 95% confidence interval (CI), 1.03-1.18) than those with longer dinner-to-bed time. However, no significant association was observed between shorter dinner-to-bed time and otitis media or allergic rhinitis. Furthermore, supplementary analyses revealed that the risk of asthma was significantly higher in children born in 2001 (aRR = 1.13; 95% CI, 1.04-1.22). CONCLUSION: This study showed that dinner-to-bed time within 120 minutes after dinner increases the risk of developing asthma. This underscores the importance of considering lifestyle modifications, as certain pediatric asthma cases may be influenced by behaviors that promote GER.

DOI： 10.7759/cureus.77709

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Authorship：Lead author   Language：Japanese   Publisher：岡山医学会  

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Language：Japanese   Publisher：(株)医学書院  

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Language：Japanese   Publisher：(株)全日本病院出版会  

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

We report a challenging and uncommon case involving a 53-year-old Japanese man with cerebrospinal fluid (CSF) leakage caused by a meningocele in the lateral recess of the sphenoid sinus. Our innovative treatment approach involved a combination of transpterygoid and endoscopic modified medial maxillectomy techniques, with special emphasis on the preservation of the sphenopalatine artery. This strategic preservation was pivotal to the successful use of the ipsilateral nasoseptal flap for reconstruction, which played a crucial role in the prevention of postoperative CSF leakage. Otolaryngologists and neurosurgeons collaborated to perform the bath-plugging technique; effective collaboration was instrumental to the success of the procedure. This report highlights significant advancement from conventional frontal craniotomy to a more sophisticated endoscopic technique, shows the importance of meticulous surgical planning and execution, emphasizes careful preservation of critical anatomical structures during complex neurosurgical and otolaryngological procedures, and underscores the evolving landscape of surgical approaches for managing complex medical conditions.

DOI： 10.1016/j.anl.2024.08.003

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BACKGROUND: In 2013, Japan established a standardized classification system for categorizing endoscopic sinus surgery (ESS) into types I-V, yet no evaluation has been conducted thereof. OBJECTIVE: We assessed the ESS trends and status in Japan, focusing on outpatient and inpatient surgeries. MATERIAL AND METHODS: This descriptive retrospective cohort study used Japan's National Database of Health Insurance Claims and Specific Health Checkups between 2014 and 2021. The distribution of ESS types I-V and outpatient and inpatient surgeries was analysed, along with age groups and regional differences, focusing on ESS type III. RESULTS: Overall, 427,813 ESS procedures were performed, with types III and IV being most common. Outpatient ESS type III increased substantially compared to inpatient surgeries. Younger individuals favoured outpatient ESS type III over inpatient surgeries, with substantial regional variations across prefectures. CONCLUSIONS AND SIGNIFICANCE: The adoption of a standardized ESS classification in Japan has facilitated a detailed understanding of surgical trends. The shift toward outpatient surgeries, especially for type III ESS, aligns with global trends toward minimally invasive procedures and reflects changing patient preferences and healthcare delivery practices. Consequently, continuous monitoring and research are crucial for adapting surgical practices to the evolving healthcare needs and patient expectations.

DOI： 10.1080/00016489.2024.2389179

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

Here, we describe the unique case of a pneumocephalus originating from an inverted papilloma (IP) in the frontoethmoidal sinus. A 71-year-old man with diabetes presented with headaches and altered consciousness. Imaging revealed the pneumocephalus together with bone destruction in the left frontal sinus. He underwent simultaneous endoscopic endonasal and transcranial surgery using an ORBEYE exoscope. Pathological diagnosis of the tumor confirmed IP. Post-surgery, the pneumocephalus was significantly resolved and the squamous cell carcinoma antigen level, which had been elevated, decreased. This case underscores the importance of a multidisciplinary approach and innovative surgical methods in treating complex sinonasal pathologies.

DOI： 10.18926/AMO/67550

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OBJECTIVE: There is no consensus on the optimal surgical technique for allergic rhinitis (AR). Furthermore, the appropriateness of surgical intervention in children and older individuals remains debatable. This study aimed to analyze trends and patterns in the surgical management of AR in Japan, focusing on parasympathetic neurectomy. METHODS: Using the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB), we conducted a comprehensive review of procedures performed between April 2014 and March 2022. In addition, a cross-sectional survey targeting otolaryngologists across Japan was conducted to gather insights into surgical preferences and practices. RESULTS: The NDB data showed an increasing trend in neurectomies, with the most frequent age group being 25-29 years; the procedure was also performed in pediatric and older patients. The survey among otolaryngologists indicated that 58.2 % of surgeons preferred peripheral branch neurectomy of the posterior nasal nerve. The findings of this study also indicated a cautious approach toward conducting these procedures in children, with 51.2 % of surgeons considering patients less than 18 years of age unsuitable for the procedure. CONCLUSION: This study highlighted a shift toward simple and minimally invasive surgical methods, such as peripheral branch neurectomy, in Japan. However, further research is needed to understand the long-term outcomes and refine the surgical techniques. The findings of this study also emphasized the need for age-specific considerations when treating pediatric and older patients with AR.

DOI： 10.1016/j.anl.2024.07.005

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DOI： 10.1016/j.alit.2024.01.005

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BACKGROUND: Otitis media (OM) is a prevalent respiratory disease in children and poses significant public health challenges due to its impact on child health and economic burdens. However, there have no nationwide epidemiological studies conducted in Japan. This study investigates the epidemiological trends of OM in Japan, taking into account the impact of the 7-valent pneumococcal conjugate vaccine (PCV7) introduction. METHOD: This study was retrospective cohort study using secondary data on the nationwide longitudinal birth cohort. This survey followed two cohorts born in 2001 (pre-PCV era) and 2010 (post-PCV era) until the age of 9. Every year, parents were surveyed about their children's health status, including occurrences of OM. The annual period prevalence and cumulative incidence of OM were assessed in this study, and the two cohorts were compared using a modified Poisson regression model adjusted environmental factors with the 2001 cohort as reference. RESULT: The study included 47,015 children from the 2001 cohort and 38,554 from the 2010 cohort. Peak annual period prevalence of OM varied by era. Cumulative incidence was 13.8 % for the 2001 cohort and 18.5 % for the 2010 cohort by 1.5 years of age and 28.9 % and 33.3 %, respectively, by 3.5 years of age. In particular, from the fourth survey onward, covering ages 2.5-3.5 years, a shift was observed from an increased risk to a decreased risk of OM. CONCLUSION: This nationwide longitudinal study emphasizes variations in OM epidemiology across Japan over time, with changes potentially influenced by the introduction of PCV7. In this study, due to the absence of individual PCV7 vaccination data, the effect of PCV7 was estimated based on the vaccination rate at the population level. The results suggest a notable decrease in the incidence of OM in later years, aligning with the increased uptake of PCV7.

DOI： 10.1016/j.vaccine.2024.05.020

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: Advanced surgical interventions are required to treat malignancies in the anterior skull base (ASB). This study investigates the utility of endoscopic endonasal and transcranial surgery (EETS) using a high-definition three-dimensional exoscope as an alternative to traditional microscopy. METHODS: Six patients with carcinomas of varying histopathologies underwent surgery employing the EETS maneuver, which synchronized three distinct surgical modalities: harvesting of the anterolateral thigh flap, initiation of the transnasal technique, and initiation of the transcranial procedure. RESULTS: The innovative strategy enabled successful tumor resection and skull base reconstruction without postoperative local neoplastic recurrence, cerebrospinal fluid leakage, or neurological deficits. CONCLUSION: The integration of the exoscope and EETS is a novel therapeutic approach for ASB malignancies. This strategy demonstrates the potential of the exoscope in augmenting surgical visualization, enhancing ergonomics, and achieving seamless alignment of multiple surgical interventions. This technique represents a progressive shift in the management of these complex oncological challenges.

DOI： 10.1002/hed.27724

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BACKGROUND: The pharyngeal flap (PF) is useful for reconstruction of soft palate defects, but effective arrangements of PF for various types of soft palate defects are controversial. Here, we classify three types of soft palate defects and discuss the arrangements of PF and their functional prognosis. METHODS: Reconstruction was performed based on the classification of the defects. Clinical details were collected, and postoperative function was analyzed. RESULTS: Eight patients were included in the study. The defect sizes ranged from 25 (width) × 40 (depth) to 40 × 60 mm. Six patients underwent pharyngeal flap reconstruction with free-flap reconstruction, and two underwent pharyngeal flap reconstruction. The pharyngeal flap was harvested at the maximum width of the posterior pharyngeal wall, ranging from 25 to 40 mm in length. Eating and speaking functions were maintained in all patients. CONCLUSIONS: Good postoperative function can be maintained by narrowing the velopharyngeal space with a pharyngeal flap.

DOI： 10.1002/hed.27712

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Language：Japanese   Publisher：(株)メディカルレビュー社  

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OBJECTIVES: The purpose of this study is to investigate the lung function in Chronic Rhinosinusitis (CRS) patients with Chronic Cough (CC). METHODS: A total of 1413 CC patients were retrospectively screened and 109 CRS patients with CC were enrolled. Lung function, Lund-Mackay Computed Tomography (CT) score, smoking status, peripheral blood eosinophil count, and immunoglobulin E concentration in serum samples, and Sino-Nasal Outcome Test were examined. Normal control subjects are also recruited. RESULTS: The Forced Expiratory Volume in 1 second (FEV1.0), Percent Predicted FEV1.0, and FEV1.0/Forced Vital Capacity (FVC) ratio in the patients were significantly low as compared with the control subjects. The FEV1.0/FVC ratio was negatively correlated with the Lund-Mackay CT scores of the patients with a high CT score. CONCLUSIONS: The CRS patients with CC should be investigated with lung function. In addition, the multidisciplinary evaluation including a pulmonologist is needed to manage the CRS patients with CC. LEVEL OF EVIDENCE: Level 4.

DOI： 10.1016/j.bjorl.2024.101424

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This study investigated the association between housing type and clinical remission of infantile-onset allergic rhinitis (AR) in 53,575 children born in 2001 in Japan. Infantile-onset AR was defined as the presence of AR symptoms reported between ages 1.5 and 4.5 years, and remission was assessed between ages 10 and 12. The type of housing was categorized into detached houses and multi-unit residential buildings with 1-2, 3-5, or ≥6 floors. Among the 4,352 infantile-onset AR, 42.9% experienced remission. Notably, living in multi-unit residential buildings, particularly those with 1-2 and ≥6 floors, was positively associated with AR remission.

DOI： 10.1016/j.pedhc.2023.11.011

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

Objectives This retrospective study aimed to investigate the relationships between the Keros classification, the Gera classification, the vertical height of the posterior ethmoid roof (ER), and anterior ethmoidal artery (AEA) types in Japanese patients. Methods We investigated the computed tomography (CT) slices of paranasal sinuses (120 sides) of 60 patients; measured the cribriform plate (CP) depth, lateral lamella CP angle (LLCPA), and vertical height of the lateral ER from the hard palate (LERHP) at the coronal plane of the posterior ethmoidal artery (PEA); and reviewed the AEA types, whether floating or non-floating. Results CP depth was positively correlated with LLCPA (r=0.63; p<0.01) and the height of LERHP (r=0.19; p<0.05). The height of the LERHP in females was significantly lower than that in males. With increased CP depth, floating AEAs became prevalent (p<0.001). Conclusion In females, low height of the posterior ethmoid sinus roof, where cerebrospinal fluid (CSF) leaks occurred while penetrating the basal lamella, often existed; the heights positively correlated with the Keros classification in Japanese patients. The Keros and Gera classifications, AEA type, and posterior ER height do not individually constitute a complete risk assessment but may correlate, preventing major complications, such as CSF leak and orbital hemorrhage.

DOI： 10.7759/cureus.49273

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Language：English  

Low-grade papillary Schneiderian carcinoma (LGPSC) is a rare and newly described type of cancer arising from the Schneiderian epithelium. Owing to cellular atypia, it is difficult to differentiate this type from other papillomas and malignancies. Although this condition remains unclear, it is associated with mortality and recurrence. Therefore, treating physicians should be aware of the possibility of LGPSC for prompt diagnosis and treatment. In this article, we present an additional case of nasopharyngeal LGPSC with cervical lymph node metastasis and reviewed the 14 cases reported thus far in the literature. A 76-year-old female was referred to our department for detailed examination of nasopharyngeal and cervical lymph node tumors detected by positron emission tomography-computed tomography. Based on the biopsy of the nasopharyngeal tumor, we suspected LGPSC. Considering the clinical course and pathological findings, the patient was diagnosed with cervical lymph node metastasis through neck dissection. We performed radiotherapy for the primary lesion of the nasopharynx, which led to the disappearance of the tumor. After 13 months following the radiotherapy, the patient died from a recurrence of retroperitoneal liposarcoma without the recurrence of LGPSC.

DOI： 10.1016/j.anl.2022.12.010

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Language：Japanese   Publisher：(株)医学書院  

当院では慢性副鼻腔炎に対する内視鏡下鼻副鼻腔手術(ESS)後の出血予防を目的とした鼻内パッキングにナゾポア(日本ストライカー社)を用いている。今回、2020年12月～2021年12月にナゾポアを使用した46例の成績を報告した。ESSのクリニカルパス逸脱を伴う出血を認めたのは1例のみであり、再手術を要する大出血や重症感染症は認めなかった。ナゾポアに抗菌薬やステロイドを浸潤させることで創傷治癒促進も期待できることから、ナゾポアはESS後の鼻内パッキングに有用と考えられた。

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

PURPOSE: A longitudinal study was conducted to examine the effects of handwashing and gargling education for children on the prevention of respiratory tract infections (RTIs) in children in Japan. METHODS: The study included 38,554 children born in 2010 who were enrolled in a longitudinal study. Information on children's hygiene education regarding handwashing and gargling was collected in a survey at the age of 3.5 years. Based on parents' reports of doctors' diagnoses, airway infections and influenza events in the 12-month duration before the survey were evaluated for RTIs at the ages of 4.5 and 9 years. Poisson regression with robust variance was performed to examine the effects of hygiene education on RTIs prevention. The supplementary analysis was stratified by household income. RESULTS: Children were categorized into different groups: 38% in the handwashing and gargling group, 29% in the handwashing group, 0.1% in the gargling group, and 9.7% in the no-education group. Exclusions were made for non-respondent children (23%) and those in the gargling group. Hygiene education was associated with decreased influenza at the age of 4.5 years in the handwashing (adjusted RR [aRR] = 0.8; 95% CI, 0.8-0.9) and handwashing and gargling groups (aRR = 0.8; 95% CI, 0.8-0.9) compared with no education. However, no preventive effects on airway infections at the age of 4.5 and 9, influenza at the age of 9, or hospitalization between the ages of 3.5 and 9 years were detected. Handwashing and gargling could significantly prevent influenza in low-income households (aRR = 0.7; 95% CI, 0.6-0.8).     Conclusions: Gargling education was widespread and mostly combined with handwashing education in Japan. Hygiene education significantly affected prevention of influenza infections at the age of 4.5 years, especially in low-income households. WHAT IS KNOWN: • Previous intervention studies showed handwashing and gargling are effective in preventing respiratory tract infections. WHAT IS NEW: • We conducted a longitudinal study on handwashing and gargling education in Japanese children and found that handwashing and gargling were widely practiced together. • Handwashing and gargling education were related to a reduction in influenza, particularly in low-income households.

DOI： 10.1007/s00431-023-05062-5

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Other Link： https://link.springer.com/article/10.1007/s00431-023-05062-5/fulltext.html

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

BACKGROUND: Chronic rhinosinusitis (CRS) can be divided into endotypes by functional or pathophysiologic findings. OBJECTIVE: The aim of this study was to analyze the expression of cytokines, prostaglandin (PG) synthases, and their receptors related to the pathogenesis of CRS, especially those contributing to nasal polyp (NP) formation. METHODS: NPs and uncinate tissue (UT) samples were collected from 90 patients who underwent endoscopic sinus surgery. They included 75 patients with CRS (including 45 with eosinophilic CRS [eCRS] and 30 with non-eCRS) and 15 patients without CRS. A total of 30 genes were selected for our original DNA array plate to analyze the levels of expression of 10 cytokines (IFN-γ, IL-4, IL-5, IL-10, IL-13, IL-17A, IL-22, IL-25, IL-33, and TSLP), 4 prostaglandin synthases (prostaglandin D2 [PGD2] synthase, prostaglandin E2 synthase, COX-1, and COX-2), and their 16 receptors. Clustering analysis was performed according to the expression results, and clinical findings of patients from each cluster were investigated. RESULTS: The samples could be divided into 3 clusters. Cluster 1 showed elevated levels of expression of IL4, IL5, IL13, TSLP, IL1RL1 (ST2 [an IL-33 receptor]), HPGDS, and GPR44 (CRTH2, a PGD2 receptor); cluster 2 showed elevated levels of expression of IL17A and PTGES; and cluster 3 showed an elevated level of expression of IL25. Regarding clinical features, the main characteristics of each cluster were as follows: NPs from patients with eCRS for cluster 1, NPs and/or UT samples from patients with non-eCRS for cluster 2, and UTs from patients with non-CRS for cluster 3. CONCLUSION: The results suggest that there are associations between type 2 inflammation/PGD2 and eCRS and also between type 3 inflammation/prostaglandin E2 and non-eCRS.

DOI： 10.1016/j.jacig.2023.100123

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.18926/AMO/64033

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Language：Japanese   Publisher：(株)医学書院  

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Language：Japanese   Publisher：耳鼻咽喉科臨床学会  

症例は77歳男性で、2週間前頃から喉頭違和感を自覚しており、当科初診日深夜に呼吸困難が出現したため当院に救急搬送された。精査によりたこつぼ型心筋症と狭心症が明らかとなり、さらにCTで気管狭窄を伴う甲状腺腫瘍が認められた。急速に増大する甲状腺腫瘍であったため、未分化癌や悪性リンパ腫を疑い穿刺吸引細胞診を施行したが、検体不良との結果で診断を得られなかった。早期の確定診断に加え、気道管理の面から経皮的な気道確保への移行が必要と判断し、入院4日目に輪状軟骨開窓術と開放生検を同時に行う方針とした。術後2週目にび漫性大細胞性リンパ腫の確定診断に至り、たこつぼ型心筋症と狭心症は呼吸・循環管理により改善していたため、血液内科に転科のうえ術後21日目から化学療法が開始され、6コース完遂後に腫瘍は完全奏効となった。

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Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2022&ichushi_jid=J00580&link_issn=&doc_id=20220705240012&doc_link_id=10.5631%2Fjibirin.115.619&url=https%3A%2F%2Fdoi.org%2F10.5631%2Fjibirin.115.619&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

Authorship：Lead author   Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J07551&link_issn=&doc_id=20220628380018&doc_link_id=10.3950%2Fjibiinkotokeibu.125.6_1041&url=https%3A%2F%2Fdoi.org%2F10.3950%2Fjibiinkotokeibu.125.6_1041&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Authorship：Lead author,　Corresponding author   Language：English  

DOI： 10.1016/j.alit.2022.03.003

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DOI： 10.1016/j.alit.2021.11.002

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(株)医学書院  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J02122&link_issn=&doc_id=20220405090009&doc_link_id=10.11477%2Fmf.1411202961&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1411202961&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.3390/diagnostics12020454

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DOI： 10.1001/jamaoto.2021.3392

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Language：Japanese   Publisher：(NPO)日本頭頸部外科学会  

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(一社)日本鼻科学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2021&ichushi_jid=J01675&link_issn=&doc_id=20220111400012&doc_link_id=10.7248%2Fjjrhi.60.546&url=https%3A%2F%2Fdoi.org%2F10.7248%2Fjjrhi.60.546&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

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DOI： 10.1016/j.anorl.2021.04.009

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(株)医学書院  

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1080/00016489.2021.1925151

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DOI： 10.1007/s00455-020-10196-x

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2021&ichushi_jid=J01675&link_issn=&doc_id=20210506380001&doc_link_id=10.7248%2Fjjrhi.60.1&url=https%3A%2F%2Fdoi.org%2F10.7248%2Fjjrhi.60.1&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1177/1945892420932781

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DOI： 10.1016/j.mmcr.2020.09.004

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DOI： 10.1016/j.anl.2020.05.012

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2020&ichushi_jid=J01987&link_issn=&doc_id=20201228330001&doc_link_id=%2Fch6menek%2F2020%2F003803%2F001%2F0057-0063%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fch6menek%2F2020%2F003803%2F001%2F0057-0063%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publisher：香川労災病院  

症例1は54歳男性で、数ヵ月前からの視力低下を自覚して近医眼科を受診、両耳側半盲を指摘され、精査加療目的に当科紹介受診となった。非機能性下垂体腺腫と術前診断し、経鼻的内視鏡手術における下垂体腺腫摘出術の方針とした。術後軽度の頭痛は認めたものの両側の視力および視野は改善を認め、尿崩症等の内分泌異常、髄液漏等もなく第15病日に退院となった。病理結果は下垂体腺腫であった。症例2は68歳男性で、1年前から嗅覚障害を自覚しており、近医耳鼻科を受診、嗅覚低下・嗅裂ポリープを認め当院耳鼻咽喉科に紹介受診となった。鼻腔内所見における嗅裂ポリープの生検にて嗅神経芽細胞腫と診断された。鼻腔経由での血管処理が困難と考え、左上眼瞼皮膚切開を併用し、前篩骨動脈、後篩骨動脈の凝固切断、経鼻内視鏡下に鼻副鼻腔腫瘍、頭蓋底骨、硬膜両嗅球、両嗅索を一塊切除した。術後経過は良好で第12病日に退院となった。

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Language：Japanese   Publisher：(株)医学書院  

28歳男。出生時から顔貌異常があり、過成長を認めた。10代の頃にソトス症候群と臨床診断されていたが、全身状態が落ち着いていたため定期通院はしていなかった。今回、日中の眠気・頭痛があり、睡眠時無呼吸症候群の精査目的で当科を受診した。諸検査の結果から、下顎低形成による硬組織の異常から口腔・咽頭腔の狭小化をきたし、閉塞性睡眠時無呼吸症候群になっていると考えた。持続陽圧呼吸(CPAP)療法を行い、治療効果判定のためCPAP装着下にポリソムノグラフィ検査を行ったところ、AHI、AIとも改善していることが確認された。日中の眠気・頭痛も改善し、現在CPAPを継続しながらフォロー中である。

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Language：Japanese   Publisher：(NPO)日本頭頸部外科学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2020&ichushi_jid=J04210&link_issn=&doc_id=20200720160020&doc_link_id=10.5106%2Fjjshns.30.119&url=https%3A%2F%2Fdoi.org%2F10.5106%2Fjjshns.30.119&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(NPO)日本頭頸部外科学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2020&ichushi_jid=J04210&link_issn=&doc_id=20200720160019&doc_link_id=10.5106%2Fjjshns.30.113&url=https%3A%2F%2Fdoi.org%2F10.5106%2Fjjshns.30.113&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1097/MAO.0000000000002537

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2020&ichushi_jid=J01099&link_issn=&doc_id=20200409390011&doc_link_id=%2Fdz0jibik%2F2020%2F012303%2F011%2F0257-0263%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdz0jibik%2F2020%2F012303%2F011%2F0257-0263%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.alit.2019.11.001

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DOI： 10.1016/j.amjoto.2019.102315

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DOI： 10.1177/2050313X20915415

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DOI： 10.1016/j.anl.2019.01.010

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DOI： 10.1016/j.anl.2019.02.007

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(株)医学書院  

症例1は70歳男性で、右顔面神経麻痺と右耳痛を主訴とした。外耳道内に肉芽形成を認め、CTで右鼓室と乳突洞の軟部組織陰影、外耳道骨部から鼓室、乳突洞にかけての骨破壊像を認めた。細菌検査で右耳漏からアスペルギルスが検出された。顔面神経麻痺を伴った右悪性外耳道炎と診断し、シタフロキサシンの内服と高気圧酸素療法を行った。また、外耳道内にビホナゾールの塗布とブロー液による処置を行った。症例2は71歳男性で、両耳漏と両耳痛を主訴とした。外耳道内に肉芽形成を認め、CTで両側外耳道骨部から鼓室、乳突洞、両側下顎頭にかけて骨破壊像を認めた。細菌検査で耳漏からニューキノロン耐性緑膿菌を検出した。両側悪性外耳道炎と診断し、タゾバクタム/ピペラシリンの点滴と高気圧酸素療法を行った。2例とも経過は良好であったが、症例2は治療開始後25ヵ月に既往の悪性リンパ腫が再発し死亡した。

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(株)医学書院  

症例1は40歳男性で、反復性の左鼻出血と鼻の痛みを主訴とした。CTで左上顎洞から一部の前篩骨洞にかけて内部不均一で造影効果の乏しい腫瘤性病変を認めた。上顎洞血瘤腫を疑い、endoscopic modified medial maxillectomy(EMMM)を施行した。症例2は80歳女性で、反復性の左鼻出血を主訴とした。CTで左上顎洞に充満する陰影を認め、脳血管造影で明らかな栄養血管や腫瘍濃染を認めなかった。上顎洞血瘤腫を疑い、EMMMを施行した。症例3は73歳男性で、頭痛を主訴とした。CTで左蝶形骨洞に充満する陰影を認め、脳血管造影で明らかな栄養血管や腫瘍濃染を認めなかった。蝶形骨洞血瘤腫を疑い、拡大蝶形骨洞手術を施行した。手術は正円孔、翼突管を同定し、広く蝶形骨洞前壁を開放した術野で行った。3例とも病理診断は血瘤腫で、症例1は術後約5年、症例2は術後約8ヵ月、症例3は術後2年5ヵ月の現在まで再発を認めていない。

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1002/joa3.12130

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

: Prophylactic treatment with intranasal corticosteroids is effective for pollen-induced seasonal allergic rhinitis. However, the appropriate time to start this treatment remains unclear. We performed a double-blinded, randomized, placebo-controlled trial. Starting on February 1, 2014, patients with Japanese cedar pollinosis received either fluticasone furoate nasal spray (FFNS) for 8 weeks (Group A: n = 24), placebo nasal spray for 2 weeks followed by FFNS for 6 weeks (Group B: n = 23), or placebo for 4 weeks followed by FFNS for 4 weeks (Group C: n = 23). The primary endpoint was comparison of the total naso-ocular symptom score (TSS). Secondary endpoints including the increment cost effective ratio (ICER) were also determined. Continuous pollen dispersion began on the 24th of February. Therefore, Group A and Group B received 3-weeks and 1-week of prophylactic treatment, respectively, whereas Group C received post-onset treatment. During the peak pollen-dispersal period, significant differences in TSS were seen between the groups, particularly between Group A and C. The ICER of Group B vs. Group C was lower than that of Group A vs. Group C. These results suggest that long-term prophylactic treatment with FFNS is clinically the most potent treatment, whereas short-term prophylactic treatment is cost effective for pollen-induced allergic rhinitis.

DOI： 10.3390/medsci7010011

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OBJECTIVE: The agger nasi cell (ANC) is an easily identifiable landmark when approaching the frontal sinus. The success of endoscopic frontal sinus surgery may be influenced by the width of the frontal recess (FR). The aim of this study is to examine the relationship between the FR width and the ANC size in Japanese patients. In addition, the effect of various frontal recess cells (FRCs) on the development of frontal sinusitis has been examined. MATERIALS AND METHODS: Multiplanar computed tomography (CT) scans of the nasal cavities and paranasal sinuses in 95 patients (190 sides) before endoscopic sinus surgery were reviewed. The presence of FRCs, the thickness of the frontal beak (FB), the ANC size, and the anterior-to-posterior (A-P) length of the frontal isthmus (FI) and FR were evaluated in patients with and without frontal sinusitis. RESULTS: The prevalence of the ANC, frontal cell types 1, 2, 3, and 4, frontal bullar cell (FBC), suprabullar cell, supraorbital ethmoid cell, and interfrontal sinus septal cell was 85.3%, 11.6%, 0%, 7.9%, 0%, 25.3%, 45.8%, 16.8%, and 15.3%, respectively. The ANC volume showed a significant positive correlation with the A-P length of the FI and FR. The incidence of frontal sinusitis in the patients with FBCs was significantly higher than that without FBCs. CONCLUSION: A large ANC offers a greater potential to facilitating the approach to the frontal sinus because of the extensiveness of the FR in Japanese patients. The presence of FBCs may be related to a higher incidence of frontal sinusitis.

DOI： 10.1177/1179550619884946

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BACKGROUND: Allergic fungal rhinosinusitis (AFRS) is a noninvasive fungal disease of the sinuses with a very high recurrence rate. A very small number of Japanese cases have been reported. MATERIAL AND METHODS: The subjects were 6 patients with AFRS out of 429 patients who underwent endoscopic sinus surgery at Kagawa Rosai Hospital between December 2011 and November 2017. We retrospectively examined the clinical features and outcomes of these 6 patients. RESULTS: The incidence of AFRS was 1.4% (6/429). Allergic fungal rhinosinusitis was unilateral in 5 cases and bilateral in 1. Computed tomography revealed hyperdense areas representing allergic mucin, but no patient exhibited bone erosion. Magnetic resonance imaging showed hypointense or no signal regions at the locations of allergic mucin. Postoperatively, 1 patient developed recurrence. Because the recurrent patient had no significant symptoms, he refused further surgery and received drug therapy. Preoperative eosinophil counts and total IgE levels were elevated in all patients; postoperatively, both remained high in the patient who developed recurrence. Postoperative treatments included steroid therapy and nasal irrigation. CONCLUSIONS: Allergic fungal rhinosinusitis is less prevalent in Japan than in Western nations. Peripheral blood eosinophil and serum IgE values may be used as the biomarkers. SIGNIFICANCE: Allergic fungal rhinosinusitis is prone to recurrence. Postoperative treatment including steroid therapy is important in the management of AFRS.

DOI： 10.1177/1179550619870758

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1159/000496437

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DOI： 10.23736/S0392-6621.19.02224-0

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society of Allergology  

DOI： 10.15036/arerugi.68.35

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2019&ichushi_jid=J00009&link_issn=&doc_id=20190208340007&doc_link_id=1390845713054037760&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390845713054037760&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_3.gif

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DOI： 10.1080/00016489.2018.1515499

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Language：Japanese   Publisher：(株)東京医学社  

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Authorship：Lead author   Language：Japanese   Publisher：(株)東京医学社  

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1002/hed.25196

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DOI： 10.1016/j.alit.2018.02.001

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2018&ichushi_jid=J01675&link_issn=&doc_id=20180724360004&doc_link_id=10.7248%2Fjjrhi.57.138&url=https%3A%2F%2Fdoi.org%2F10.7248%2Fjjrhi.57.138&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.anl.2017.06.002

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.anl.2017.07.020

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1093/jjco/hyy009

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2017&ichushi_jid=J01675&link_issn=&doc_id=20180122310012&doc_link_id=10.7248%2Fjjrhi.56.625&url=https%3A%2F%2Fdoi.org%2F10.7248%2Fjjrhi.56.625&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：Japanese   Publisher：(一社)日本鼻科学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2017&ichushi_jid=J01675&link_issn=&doc_id=20180122310003&doc_link_id=10.7248%2Fjjrhi.56.564&url=https%3A%2F%2Fdoi.org%2F10.7248%2Fjjrhi.56.564&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：Japanese   Publisher：(NPO)日本気管食道科学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2017&ichushi_jid=J01054&link_issn=&doc_id=20170622400001&doc_link_id=%2Fea4broes%2F2017%2F006803%2F001%2F0217-0221%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fea4broes%2F2017%2F006803%2F001%2F0217-0221%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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DOI： 10.1016/j.jos.2015.09.001

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Language：Japanese   Publisher：(株)医薬ジャーナル社  

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DOI： 10.1016/j.alit.2016.04.017

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DOI： 10.2500/ar.2017.8.0208

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Authorship：Lead author   Language：Japanese   Publisher：(一社)日本鼻科学会  

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DOI： 10.1016/j.alit.2016.03.003

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Language：Japanese  

Brainstem/cerebellar infarction is known to cause various cranial nerve symptoms that may require otorhinolaryngological evaluation. Acute-phase cerebellar infarction is evaluated by MRI with diffusion-weighted imaging (MRI-DWI). However, in the acute phase, MRI-DWI may show false-negative results, because of which patients are referred to the department of otolaryngology for further evaluation of the cranial nerve symptoms. We investigated 250 cases of brainstem/cerebellar infarction in 245 patients who were admitted to our hospital between 2010 and 2015. Of the 250 cases, eight cases were diagnosed at the department of otolaryngology after detailed evaluators for dizziness or dysphagia, and three of them were false negative on initial MRI-DWI. In total, we examined 16 cases detected as false negatives upon initial MRI-DWI. Of the 16 cases, 12 were brainstem infarctions, three were cerebellar infarctions, and one was infarction of the brainstem and cerebellum. All 16 cases were evaluated by initial MRI-DWI within 12 h of onset. Careful observation of the neurological findings and follow-up MRI-DWI are useful for the detailed evaluation of patients suspected to have a cerebellar infarction.

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Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2016&ichushi_jid=J01099&link_issn=&doc_id=20161114550003&doc_link_id=%2Fdz0jibik%2F2016%2F011910%2F003%2F1290-1299%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdz0jibik%2F2016%2F011910%2F003%2F1290-1299%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publisher：(NPO)日本気管食道科学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2016&ichushi_jid=J01054&link_issn=&doc_id=20160829410006&doc_link_id=%2Fea4broes%2F2016%2F006704%2F006%2F0283-0288%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fea4broes%2F2016%2F006704%2F006%2F0283-0288%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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DOI： 10.1016/j.alit.2015.12.007

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Authorship：Lead author   Language：Japanese   Publisher：(株)医学書院  

鼻口蓋管嚢胞の根治的治療法として一般に嚢胞全摘出術が行われるが、嚢胞が巨大な場合には摘出後の死腔の処理が問題となる。今回著者等は、巨大な嚢胞に対して内視鏡下鼻内手術を行い、嚢胞を両側鼻腔に開窓し、良好な結果が得られたので報告した。症例は38歳男で、嚢胞の大きさは画像検査上57×56×48mmで、鼻腔底部と口蓋部に骨欠損があり、摘出術を施行した場合には鼻腔と口蓋の間に瘻孔を形成する可能性があった。また、手術で口腔内に開窓すると創が汚染され、鼻腔と口蓋の間に瘻孔を形成する可能性もあった。さらに、鼻腔底に嚢胞壁が大きく進展していたため、手術では、鼻腔粘膜よりも強固な口蓋粘膜を温存して嚢胞を鼻腔に開窓した。

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Authorship：Lead author   Language：Japanese   Publisher：(株)医学書院  

2012年1月から2015年6月までに保存的治療で十分な治療効果が得られず、内視鏡下副鼻腔手術(ESS)を行った好酸球性副鼻腔炎(ECRS)45症例を対象として、術前後の自覚症状、quality of life(QOL)の変化と内視鏡所見の変化について検討した。術前、術後3ヵ月前後、6ヵ月前後の時点での鼻症状アンケートで自覚症状、QOLに関する質問を評価するとともに、鼻内ポリープスコアを用いて内視鏡評価を比較した結果、自覚症状スコア、QOLスコアの両方において、術後3ヵ月、6ヵ月ともに嗅覚低下、鼻閉やTotal Nasal Symptom Scoreなど多くの項目で有意な改善を認め、概ね良好な術後経過をたどった。

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1002/hed.23992

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DOI： 10.1016/j.alit.2015.08.005

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Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.jaci.2014.10.058

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Language：Japanese   Publisher：(株)全日本病院出版会  

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Authorship：Lead author   Language：Japanese   Publisher：(一社)日本鼻科学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2015&ichushi_jid=J01675&link_issn=&doc_id=20150827370006&doc_link_id=10.7248%2Fjjrhi.54.31&url=https%3A%2F%2Fdoi.org%2F10.7248%2Fjjrhi.54.31&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Authorship：Lead author   Language：Japanese   Publisher：岡山医学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2015&ichushi_jid=J00175&link_issn=&doc_id=20150423220009&doc_link_id=10.4044%2Fjoma.127.55&url=https%3A%2F%2Fdoi.org%2F10.4044%2Fjoma.127.55&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：Japanese   Publisher：耳鼻咽喉科臨床学会  

45歳男。3日前に急激な頸部痛、嚥下痛および頸部可動域制限が出現し、前医でロキソプロフェンナトリウムを処方されるも改善しなかった。血液検査で白血球数とCRP値の軽度高値を認め、CTで咽後部に低吸収領域を認めたが、膿瘍を疑う周囲の造影効果は認めなかった。また、頸長筋腱が停止する環軸椎前面に石灰沈着を認めた。なお、前医でのMRIではT2強調像で椎前部に高信号領域を認めていた。以上より石灰沈着性頸長筋腱炎と診断し、前医からのロキソプロフェンナトリウムは継続とし、シメチジン1回量200mgを朝夕食後で追加した。シメチジン開始翌日には、初診時の疼痛を10として6まで疼痛が改善し、3日後には2まで改善して頸部回旋が可能になった。初診後4日後には疼痛は1まで改善し、白血球数とCRP値も正常化した。初診後11日に疼痛は消失し、CTで環軸椎前面の石灰化が縮小し吸収傾向にあることを確認し、26日後にシメチジンを中止した。

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2015&ichushi_jid=J00580&link_issn=&doc_id=20150306220012&doc_link_id=10.5631%2Fjibirin.108.243&url=https%3A%2F%2Fdoi.org%2F10.5631%2Fjibirin.108.243&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.3109/00016489.2015.1049664

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.2332/allergolint.14-OA-0703

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Authorship：Lead author   Language：Japanese   Publisher：(一社)日本鼻科学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2014&ichushi_jid=J01675&link_issn=&doc_id=20150601320007&doc_link_id=10.7248%2Fjjrhi.53.542&url=https%3A%2F%2Fdoi.org%2F10.7248%2Fjjrhi.53.542&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Authorship：Lead author   Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：香川労災病院  

当院では下垂体部腫瘍に対する手術のアプローチ方法として、以前は手術用顕微鏡を用いたSublabial approach(以下Hardy法)を施行していたが、21012年10月から内視鏡下経鼻手術(以下;経鼻)を導入した。今回、Hardy法を施行した群(10例)と経鼻施行群(15例)とで「手術時間」「入院日数」「合併症」などを比較検討した。結果、手術時間はHardy法群が平均290分、経鼻群が249分、入院日数はそれぞれ平均19.5日、15.3日であった。合併症はHardy法群で副腎機能低下を1例(10%)、鼻出血を1例(10%)、尿崩症を2例(20%)に認め、経鼻群で副腎機能低下を1例(7%)、尿崩症を6例(40%)に認めた。Hardy法と経鼻の両方を経験した症例が6例あり、その感想は総じて「経鼻のほうが術後に楽だった」とのことであった。代表例として経鼻群の1例を提示した。

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Language：Japanese   Publisher：香川労災病院  

当院における2013年度の外来化学療法件数は5709件で、統計をとり始めた2006年度から7年連続で増加しており、2006年度の2倍以上に増加した。曜日別の件数をみると、2012年度には、最も多い曜日と少ない曜日で1.7倍の開きがあったが、2013年度は医師の外来日を変更したことで曜日によるバラツキが減少した。2009～2013年度における件数の推移を原疾患別にみると、血液疾患のみが増加し続けており、乳癌は2011年まで減少傾向にあったが、その後増加し、血液疾患に次いで2番目の数となっている。2006～2013年度における件数の推移を診療科別にみると、2010年までは外科の件数が圧倒的に多かったが、内科が急激に増加しており、2013年には外科を上回った。このほか、婦人科と泌尿器科の件数も緩やかに増加し続けている。当院の外来化学療法は今後も増加すると予想されることから、安全で効率的な外来化学療法室の運用を行えるよう、人員の確保や職員の教育システム構築が必要と考えられる。

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Authorship：Lead author   Language：Japanese   Publisher：(株)医学書院  

症例は68歳男性で、右眼痛、頭痛で近医CTにて浸潤性副鼻腔真菌症、副鼻腔腫瘍を疑い紹介受診した。両側内視鏡下副鼻腔手術を行い、両側上顎洞、右篩骨洞、右蝶形骨洞にアスペルギルス様真菌塊を認め、抜去後洗浄して終了した。術翌日よりボリコナゾール(VRCZ)内服を開始した。初診4ヵ月後のCTで右蝶形骨洞内の再燃を認め、右蝶形骨洞単洞化手術を行った。術後も生食洗浄を続けたが、早期に粘膜が肥厚し、術後1ヵ月で右蝶形洞内は肉芽に覆われた。初診8ヵ月後に右蝶形骨洞内の肉芽除去、真菌除去を行った。術前のβ-D-グルカン値の異常高値を認め、問診で無症状のためVRCZ内服を自己中断していたことが判明し、手術後にVRCZ内服のコンプライアンスは改善し、術後1ヵ月半で蝶形骨洞の肉芽は消失した。β-D-グルカン値も正常に回復し、服薬履行確認にtherapeutic drug monitoringを開始した。現在約1年経過で蝶形骨洞の所見も良好な状態を維持している。

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.2500/ar.2014.5.0078

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DOI： 10.1017/S0022215114000450

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Language：Japanese   Publisher：(有)科学評論社  

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Language：Japanese   Publisher：(NPO)日本頭頸部外科学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2013&ichushi_jid=J04210&link_issn=&doc_id=20131127350004&doc_link_id=10.5106%2Fjjshns.23.141&url=https%3A%2F%2Fdoi.org%2F10.5106%2Fjjshns.23.141&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

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DOI： 10.1002/lary.23795

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Authorship：Lead author   Language：Japanese   Publisher：耳鼻咽喉科臨床学会  

86歳男。鼻中隔膿瘍は切開排膿によって改善した。蝶形骨洞アスペルギルス症に対しては内視鏡下鼻内副鼻腔手術による真菌塊除去後にボリコナゾール(VRCZ)投与を開始したが、症状は増悪した。その後、鼻中隔膿瘍の菌培養検査での真菌MIC値を参考にして抗真菌剤をミカファンギンナトリウムとイトラコナゾールに変更したところ、症状は改善した。本例はVRCZに抵抗性のアスペルギルス症であり、真菌MIC値は薬剤選択に非常に有用であった。

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2013&ichushi_jid=J00580&link_issn=&doc_id=20130227280005&doc_link_id=10.5631%2Fjibirin.106.213&url=https%3A%2F%2Fdoi.org%2F10.5631%2Fjibirin.106.213&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

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DOI： 10.1159/000341668

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DOI： 10.1016/j.anai.2012.08.016

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DOI： 10.1002/lary.23429

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DOI： 10.1111/j.1365-2222.2012.04015.x

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Authorship：Lead author   Language：Japanese   Publisher：耳鼻咽喉科臨床学会  

67歳女性。咬合時の左顔面違和感を主訴に近医を受診、CT検査にて左翼口蓋窩腫瘍を疑われ、著者らの施設へ紹介となった。所見では副鼻腔CTで左上顎洞後方、翼口蓋窩に長径14mmと短径6mmのニ房性の嚢胞状腫瘤が認められた。また、MRIでは同部位にT1にて低信号、T2にて低信号と高信号が混在する腫瘤が確認された。以上、これらの画像所見を踏まえ、本症例は嚢胞性病変を考え、しばらく経過観察としていたが、左滲出性中耳炎を合併し、MRIで腫瘤サイズの増大とともに左乳突蜂巣に液体貯留が認められた。そこで、診断確定目的で内視鏡下鼻内副鼻腔手術を行なったところ、病理組織学的に翼口蓋窩に発生した類表皮嚢胞と診断された。経過は術後より咬合時の左顔面違和感が改善し、左滲出性中耳炎も治癒が得られた。目下、術後1年経過で開放部の閉塞や滲出性中耳炎の再燃はみられていない。

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2012&ichushi_jid=J00580&link_issn=&doc_id=20120705310005&doc_link_id=10.5631%2Fjibirin.105.631&url=https%3A%2F%2Fdoi.org%2F10.5631%2Fjibirin.105.631&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

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DOI： 10.2332/allergolint.11-OA-0382

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DOI： 10.1111/j.1365-2249.2010.04292.x

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DOI： 10.1111/j.1365-2222.2010.03584.x

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DOI： 10.1016/j.jaci.2010.09.029

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Authorship：Lead author   Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2010&ichushi_jid=J01987&link_issn=&doc_id=20101108350001&doc_link_id=%2Fch6menek%2F2010%2F002803%2F001%2F0217-0222%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fch6menek%2F2010%2F002803%2F001%2F0217-0222%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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DOI： 10.1016/j.jaci.2010.05.014

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Authorship：Lead author   Language：Japanese   Publisher：(株)医薬ジャーナル社  

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DOI： 10.1016/j.jaci.2009.01.047

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japan Society of Stomato-pharyngology  

Renal metastasis originating from metachronous development of hypopharyngeal and esophageal cancer is reported. A 60-year-old man had received pharyngolaryngectomy for hypopharyngeal cancer in 2003. He had stomachache in 2005 and a right renal tumor was found with CT and MRI. Percutaneous needle biopsy was performed and histological results showed squamous cell carcinoma. At the same time, squamous cell carcinoma was detected in the esophagus. He had chemotherapy but it was ineffective. This case was thought to be a rare case of metastatic renal cancer arising from multiple primary cancers.

DOI： 10.14821/stomatopharyngology1989.20.293

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Other Link： http://search.jamas.or.jp/link/ui/2008358660

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J07551&link_issn=&doc_id=20220428580433&doc_link_id=%2Fdz0tokei%2F2022%2Ft12504%2F019%2F0753-0753%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdz0tokei%2F2022%2Ft12504%2F019%2F0753-0753%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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DOI： 10.7248/jjrhi.55.99

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Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

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Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：日本口腔・咽頭科学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：(NPO)日本医療マネジメント学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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Language：Japanese   Publisher：(一社)日本アレルギー学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2012&ichushi_jid=J00009&link_issn=&doc_id=20121105180643&doc_link_id=%2Fcw4aller%2F2012%2F006109%2F287%2F1542-1542%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcw4aller%2F2012%2F006109%2F287%2F1542-1542%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：日本口腔・咽頭科学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科学会  

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Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

DOI： 10.15036/arerugi.61.1536_3

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：(一社)日本アレルギー学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2011&ichushi_jid=J00009&link_issn=&doc_id=20111019170237&doc_link_id=%2Fcw4aller%2F2011%2F006009%2F283%2F1326-1326%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcw4aller%2F2011%2F006009%2F283%2F1326-1326%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：English   Publishing type：Research paper, summary (international conference)  

Web of Science

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Language：English   Publishing type：Research paper, summary (international conference)  

Web of Science

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：耳鼻咽喉科臨床学会  

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Language：Japanese   Publisher：耳鼻咽喉科臨床学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科学会  

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Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

DOI： 10.15036/arerugi.60.1265_1

CiNii Article

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Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

DOI： 10.15036/arerugi.60.437_1

CiNii Article

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Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

DOI： 10.15036/arerugi.60.1424_1

CiNii Article

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Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

DOI： 10.15036/arerugi.60.503_1

CiNii Article

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Language：Japanese   Publisher：(一社)日本アレルギー学会  

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2010&ichushi_jid=J00009&link_issn=&doc_id=20101104240461&doc_link_id=10.15036%2Farerugi.59.1398_1&url=https%3A%2F%2Fdoi.org%2F10.15036%2Farerugi.59.1398_1&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：Japanese   Publisher：(一社)日本アレルギー学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2010&ichushi_jid=J00009&link_issn=&doc_id=20101104240759&doc_link_id=10.15036%2Farerugi.59.1473_1&url=https%3A%2F%2Fdoi.org%2F10.15036%2Farerugi.59.1473_1&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー学会  

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科学会  

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Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

DOI： 10.15036/arerugi.59.430_4

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Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

DOI： 10.15036/arerugi.59.1343_2

CiNii Article

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2010&ichushi_jid=J00009&link_issn=&doc_id=20101104240242&doc_link_id=10.15036%2Farerugi.59.1343_2&url=https%3A%2F%2Fdoi.org%2F10.15036%2Farerugi.59.1343_2&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：(一社)日本アレルギー学会  

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2009&ichushi_jid=J00009&link_issn=&doc_id=20090507240412&doc_link_id=%2Fcw4aller%2F2009%2F005803%2F412%2F0424-0424%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcw4aller%2F2009%2F005803%2F412%2F0424-0424%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese  

CiNii Article

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Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

DOI： 10.15036/arerugi.58.1209_1

CiNii Article

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Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

DOI： 10.15036/arerugi.58.423_4

CiNii Article

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Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

DOI： 10.15036/arerugi.58.1287_1

CiNii Article

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Language：Japanese   Publisher：一般社団法人 日本アレルギー学会  

DOI： 10.15036/arerugi.58.1288_2

CiNii Article

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2009&ichushi_jid=J00009&link_issn=&doc_id=20091009240611&doc_link_id=10.15036%2Farerugi.58.1288_2&url=https%3A%2F%2Fdoi.org%2F10.15036%2Farerugi.58.1288_2&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：Japanese   Publisher：日本口腔・咽頭科学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2006&ichushi_jid=J02661&link_issn=&doc_id=20060825190103&doc_link_id=10.14821%2Fstomatopharyngology1989.19.1_112&url=https%3A%2F%2Fdoi.org%2F10.14821%2Fstomatopharyngology1989.19.1_112&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：Japanese   Publisher：日本口腔・咽頭科学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2006&ichushi_jid=J02661&link_issn=&doc_id=20060825190089&doc_link_id=10.14821%2Fstomatopharyngology1989.19.1_98&url=https%3A%2F%2Fdoi.org%2F10.14821%2Fstomatopharyngology1989.19.1_98&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Event date： 2021.9.23 - 2021.9.25

Presentation type：Symposium, workshop panel (nominated)  

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Event date： 2019.3.19 - 2019.3.20

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Event date： 2017.9.1 - 2017.9.3

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Event date： 2017.6.16 - 2017.6.18

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Event date： 2010.11.25 - 2010.11.27

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Event date： 2010.2.18 - 2010.2.20

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Event date： 2009.10.29 - 2009.10.31

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Presentation type：Oral presentation (invited, special)  

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Presentation type：Oral presentation (invited, special)  

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Presentation type：Symposium, workshop panel (public)  

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Presentation type：Symposium, workshop panel (nominated)  

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Presentation type：Symposium, workshop panel (nominated)  

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Presentation type：Oral presentation (invited, special)  

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Presentation type：Oral presentation (invited, special)  

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Presentation type：Oral presentation (invited, special)  

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Presentation type：Oral presentation (general)  

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Presentation type：Poster presentation  

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