記述言語：英語  

Oxytocin (OXT) is a highly conserved neuropeptide that modulates social cognition, and variation in its receptor gene (Oxtr) is associated with divergent social phenotypes. The cellular mechanisms connecting Oxtr genotype to social phenotype remain obscure. We exploit an association between Oxtr polymorphisms and striatal-specific OXTR density in prairie voles to investigate how OXTR signaling influences the brain transcriptome. We discover widespread, OXTR signaling-dependent transcriptomic changes. Interestingly, OXTR signaling robustly modulates gene expression of C-type lectin-like receptors (CTLRs) in the natural killer gene complex, a genomic region associated with immune function. CTLRs are positioned to control microglial synaptic pruning; a process important for shaping neural circuits. Similar relationships between OXTR RNA and CTLR gene expression were found in human striatum. These data suggest a potential molecular mechanism by which variation in OXTR signaling due to genetic background and/or life-long social experiences, including nurturing/neglect, may affect circuit connectivity and social behavior.

DOI： 10.1101/2023.10.26.564214

PubMed

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Cephalic-phase insulin release (CPIR) occurs before blood glucose increases after a meal. Although glucose is the most plausible cue to induce CPIR, peripheral sensory systems involved are not fully elucidated. We therefore examined roles of sweet sensing by a T1R3-dependent taste receptor and sugar sensing by oral glucose transporters in the oropharyngeal region in inducing CPIR. Spontaneous oral ingestion of glucose significantly increased plasma insulin 5 min later in wild-type (C57BL/6) and T1R3-knockout mice, but intragastric infusion did not. Oral treatment of glucose transporter inhibitors phlorizin and phloretin significantly reduced CPIR after spontaneous oral ingestion. In addition, a rapid increase in plasma insulin was significantly smaller in WT mice with spontaneous oral ingestion of nonmetabolizable glucose analog than in WT mice with spontaneous oral ingestion of glucose. Taken together, the T1R3-dependent receptor is not required for CPIR, but oral glucose transporters greatly contribute to induction of CPIR by sugars.

DOI： 10.1186/s12576-023-00875-3

PubMed

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掲載種別：研究論文（学術雑誌）  

DOI： 10.1002/cne.25382

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掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.isci.2022.103991

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Informa {UK} Limited  

DOI： 10.1080/09168451.2020.1794783

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開催年月日： 2023年11月25日 - 2023年11月26日

記述言語：英語   会議種別：口頭発表（一般）  

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開催年月日： 2023年10月27日 - 2023年10月28日

記述言語：日本語   会議種別：口頭発表（招待・特別）  

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開催年月日： 2023年10月23日

記述言語：日本語   会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

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開催年月日： 2023年8月26日

記述言語：日本語   会議種別：口頭発表（一般）  

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