2021/12/17 更新

写真a

ダテ イサオ
伊達 勲
DATE Isao
所属
医歯薬学域 教授
職名
教授
外部リンク

学位

  • 医学博士 ( 岡山大学 )

研究キーワード

  • 脳腫瘍

  • 脳動脈瘤

  • 細胞移植

  • パーキンソン病

  • 神経移植

  • cell transplantation

  • brain tumor

  • cerebral aneurysm

  • vasospasm

  • Parkinson disease

  • neural transplantation

  • 脳血管攣縮

研究分野

  • ライフサイエンス / 神経科学一般

  • ライフサイエンス / 神経科学一般

  • ライフサイエンス / 脳神経外科学

学歴

  • 岡山大学   Graduate School, Division of Medicine  

    1986年4月 - 1990年9月

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  • 岡山大学    

    - 1990年

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    国名: 日本国

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  • 岡山大学   Medical School   Faculty of Medicine

    1976年4月 - 1982年3月

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    国名: 日本国

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経歴

  • 岡山大学学術研究院医歯薬学域長

    2021年4月 - 現在

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  • 岡山大学医学部   医学科長

    2019年4月 - 2021年3月

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  • 岡山大学病院   てんかんセンター長

    2013年12月 - 現在

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  • 岡山大学病院   手術部長・物流センター長

    2011年5月 - 2017年3月

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  • 岡山大学病院   副病院長

    2011年4月 - 2019年3月

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  • 岡山大学病院   小児頭蓋顔面形成センター   センター長

    2009年2月 - 現在

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  • 岡山大学大学院医歯薬学総合研究科   教授

    2003年4月 - 現在

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  • 岡山大学医学部附属病院   講師

    1999年10月 - 2003年3月

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  • 岡山大学医学部 講師   Medical School

    1999年 - 2003年

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  • 岡山大学医学部附属病院   助手

    1991年9月 - 1999年10月

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  • 岡山大学   Medical School   医員

    1990年10月 - 1991年8月

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  • 岡山労災病院   脳神経外科

    1990年6月 - 1990年9月

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  • 1988-1990 ロチェスター大学 研究員

    1988年6月 - 1990年5月

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  • Researcher,1988-1990 University of Rochester, Research associate

    1988年6月 - 1990年5月

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  • 岡山大学医学部   研究生

    1986年1月 - 1988年6月

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  • 国立岡山病院   脳神経外科

    1982年12月 - 1986年1月

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  • 岡山大学医学部附属病院   脳神経外科   医員

    1982年4月 - 1982年12月

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所属学協会

  • 日本整容脳神経外科研究会

    2016年 - 現在

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  • 日本ニューロリハビリテーション学会

    2010年 - 現在

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  • 脳神経減圧術研究会

    2008年 - 現在

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  • 日本てんかん学会

    2008年 - 現在

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  • 日本てんかん外科学会

    2005年 - 現在

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  • 日本脳神経外科手術と機器学会

    2004年 - 現在

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  • 日本脳腫瘍の外科学会

    2003年 - 現在

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  • 日本神経外傷学会

    2003年 - 現在

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  • 日本老年脳神経外科学会

    2003年 - 現在

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  • 関西脳神経外科手術研究会

    2003年 - 現在

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  • 日本脳神経救急学会

    2002年 - 現在

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  • 日本再生医療学会

    2001年 - 現在

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  • 日本神経内視鏡学会

    2000年 - 現在

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  • 日本分子脳神経外科学会

    2000年 - 現在

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  • 日本脳循環代謝学会

    2000年 - 現在

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  • 日本医学英語教育学会

    2000年 - 現在

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  • 日本脳神経血管内治療学会

    1997年 - 現在

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  • 日本脊髄外科学会

    1996年 - 現在

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  • 日本頭蓋底外科学会

    1996年 - 現在

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  • スパズム・ シンポジウム

    1995年 - 現在

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  • American Society for Neural Transplantation and Plasticity

    1992年 - 現在

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  • 日本脳神経外科学会同時通訳団

    1990年 - 現在

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  • 米国神経科学学会(Society for Neuroscience)

    1988年

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  • 日本脳神経CI学会

    1987年 - 現在

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  • 日本定位・機能神経外科学会

    1987年 - 現在

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  • 日本神経科学会

    1986年

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  • 日本脳卒中学会

    1985年 - 現在

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  • 日本脳卒中の外科学会

    1984年 - 現在

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  • 日本小児神経外科研究会

    1983年 - 現在

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  • 日本脳神経外科コングレス

    1983年 - 現在

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  • 日本脳神経外科学会

    1982年 - 現在

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  • 日本神経学会

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  • 神経組織の成長・再生・移植研究会

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委員歴

  • 日本整容脳神経外科研究会   世話人代表  

    2016年 - 現在   

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    団体区分:学協会

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  • 日本医学英語教育学会   理事長  

    2014年 - 現在   

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    団体区分:学協会

    日本医学英語教育学会

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  • 日本脳循環代謝学会   幹事  

    2014年 - 現在   

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    団体区分:学協会

    日本脳循環代謝学会

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  • 日本脳神経CI学会   世話人  

    2014年 - 現在   

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    団体区分:学協会

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  • 日本脳卒中の外科学会   理事  

    2013年 - 現在   

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    団体区分:学協会

    日本脳卒中の外科学会

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  • 日本小児神経外科学会   理事  

    2012年 - 現在   

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    団体区分:学協会

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  • 日本ニューロリハビリテーション学会   理事  

    2010年 - 現在   

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    団体区分:学協会

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  • 神経組織の成長・再生・移植研究会   幹事  

    2009年 - 現在   

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    団体区分:学協会

    神経組織の成長・再生・移植研究会

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  • 日本脳腫瘍の外科学会   理事  

    2009年 - 現在   

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    団体区分:学協会

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  • 脳神経減圧術研究会   世話人  

    2008年 - 現在   

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    団体区分:学協会

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  • 日本定位・機能神経外科学会   理事  

    2008年 - 現在   

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    団体区分:学協会

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  • 日本分子脳神経外科学会   運営委員  

    2006年 - 現在   

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    団体区分:学協会

    日本分子脳神経外科学会

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  • 日本神経外傷学会   理事  

    2006年 - 現在   

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    団体区分:学協会

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  • 日本頭蓋底外科学会   理事  

    2005年 - 現在   

      詳細を見る

    団体区分:学協会

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  • 日本脳卒中学会   評議員  

    2005年 - 現在   

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    団体区分:学協会

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  • 日本脳神経外科手術と機器学会   運営委員  

    2004年 - 現在   

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    団体区分:学協会

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  • スパズム・ シンポジウム   世話人(2017-代表世話人)  

    2003年 - 現在   

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    団体区分:学協会

    スパズム・ シンポジウム

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  • 関西脳神経外科手術研究会   世話人  

    2003年 - 現在   

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    団体区分:学協会

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  • 日本脳神経外科コングレス   運営委員  

    2003年 - 現在   

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    団体区分:学協会

    日本脳神経外科コングレス

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  • 日本神経内視鏡学会   運営委員  

    2003年 - 現在   

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    団体区分:学協会

    日本神経内視鏡学会

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  • 日本脳神経外科学会   理事  

    2003年 - 現在   

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    団体区分:学協会

    日本脳神経外科学会

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  • 日本老年脳神経外科学会   世話人  

    2003年 - 現在   

      詳細を見る

    団体区分:学協会

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  • 日本再生医療学会   評議員  

    2002年 - 現在   

      詳細を見る

    団体区分:学協会

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  • 日本脳神経救急学会   ECS委員会委員  

    2002年 - 現在   

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    団体区分:学協会

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▼全件表示

 

論文

  • 脳神経外科領域における手術部位感染 招待

    安原隆雄、伊達 勲

    脳神経外科   49 ( 5 )   1093 - 1104   2021年9月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 新時代のspinal surgery 招待 査読

    安原隆雄、伊達 勲

    脳神経外科速報   31 ( 4 )   622 - 626   2021年7月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • DBSの刺激調整法とデバイスの特徴 招待

    佐々木達也、伊達 勲

    脳神経外科   49 ( 4 )   829 - 837   2021年7月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 正常圧水頭症の診断と治療 招待

    伊達 勲

    Current Therapy   39 ( 7 )   623 - 628   2021年7月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 日本脳神経外科学会第79回学術総会を岡山で開催して

    伊達 勲

    岡山医学会雑誌   133 ( 1 )   78 - 79   2021年4月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Trends in Incidence of Intracranial and Spinal Arteriovenous Shunts: Hospital-Based Surveillance in Okayama, Japan. 国際誌

    Satoshi Murai, Masafumi Hiramatsu, Etsuji Suzuki, Ryota Ishibashi, Hiroki Takai, Yuko Miyazaki, Yuji Takasugi, Yoko Yamaoka, Kazuhiko Nishi, Yu Takahashi, Jun Haruma, Tomohito Hishikawa, Takao Yasuhara, Masaki Chin, Shunji Matsubara, Masaaki Uno, Koji Tokunaga, Kenji Sugiu, Isao Date

    Stroke   52 ( 4 )   1455 - 1459   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND AND PURPOSE: To date, the incidence of intracranial and spinal arteriovenous shunts has not been thoroughly investigated. We aimed to clarify recent trends in the rates of intracranial and spinal arteriovenous shunts in Japan. METHODS: We conducted multicenter hospital-based surveillance at 8 core hospitals in Okayama Prefecture between April 1, 2009 and March 31, 2019. Patients who lived in Okayama and were diagnosed with cerebral arteriovenous malformations, dural arteriovenous fistulas (DAVFs), or spinal arteriovenous shunts (SAVSs) were enrolled. The incidence and temporal trends of each disease were calculated. RESULTS: Among a total of 393 cranial and spinal arteriovenous shunts, 201 (51.1%) cases of DAVF, 155 (39.4%) cases of cerebral arteriovenous malformation, and 34 (8.7%) cases of SAVS were identified. The crude incidence rates between 2009 and 2019 were 2.040 per 100 000 person-years for all arteriovenous shunts, 0.805 for cerebral arteriovenous malformation, 1.044 for DAVF, and 0.177 for SAVS. The incidence of all types tended to increase over the decade, with a notable increase in incidence starting in 2012. Even after adjusting for population aging, the incidence of nonaggressive DAVF increased 6.0-fold while that of SAVS increased 4.4-fold from 2010 to 2018. CONCLUSIONS: In contrast to previous studies, we found that the incidence of DAVF is higher than that of cerebral arteriovenous malformation. Even after adjusting for population aging, all of the disease types tended to increase in incidence over the last decade, with an especially prominent increase in SAVSs and nonaggressive DAVFs. Various factors including population aging may affect an increase in DAVF and SAVS.

    DOI: 10.1161/STROKEAHA.120.032052

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  • グローバル時代の脳神経外科─若手へのメッセージ─ 招待

    伊達 勲、村井 智

    脳神経外科ジャーナル   30 ( 3 )   208 - 215   2021年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Prospective, Multicenter Clinical Study of Microvascular Decompression for Hemifacial Spasm. 国際誌

    Yoshifumi Mizobuchi, Shinji Nagahiro, Akinori Kondo, Kazunori Arita, Isao Date, Yukihiko Fujii, Takamitsu Fujimaki, Ryosuke Hanaya, Mitsuhiro Hasegawa, Toru Hatayama, Kazuhiro Hongo, Tooru Inoue, Hidetoshi Kasuya, Masahito Kobayashi, Eiji Kohmura, Toshio Matsushima, Jun Masuoka, Akio Morita, Shigeru Munemoto, Shigeru Nishizawa, Yoshihiro Okayama, Kimitoshi Sato, Taku Shigeno, Hiroshi Shimano, Hideo Takeshima, Hideki Tanabe, Iwao Yamakami

    Neurosurgery   88 ( 4 )   846 - 854   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Microvascular decompression (MVD) is the most effective procedure for hemifacial spasm (HFS). MVD results from nonspecialized or low-volume institutes are not always reliable. Most studies on MVD for HFS are retrospective and single centered; to the best of our knowledge, no prospective, multicenter studies exist. OBJECTIVE: To evaluate short- and long-term outcomes and complications in patients who underwent MVD for HFS in specialized Japanese institutions, in this multicenter, prospective, cohort study. METHODS: Included patients had undergone MVD for HFS in study centers between April 2012 and March 2015. Patients' postoperative grade of involuntary movements and complications were recorded postoperatively at 7 d (short-term) and at 1 (mid-term) and 3 (long-term) yr. RESULTS: A total of 486 patients (150 men, 336 women; mean age 53.9 yr with 181 patients over 60 yr) were enrolled during the study period. Neuromonitoring was used in 96.3% of the cases. The complete cure rate of symptom relief, mortality rate, and complication rate at short-term follow-up were 70.6%, 0%, and 15%, respectively. The long-term follow-up was completed by 463 patients (95.3%); the complete cure rate of symptom relief and complication rate were 87.1% and 3.0%, respectively. CONCLUSION: Our study revealed that under expert guidance and intraoperative neuromonitoring, the long-term curative effect rate of MVD for HFS is high, while complications are uncommon and usually transient. Our results indicate that MVD is an effective and safe treatment for patients with HFS, including elderly patients.

    DOI: 10.1093/neuros/nyaa549

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  • 特発性正常圧水頭症の診断と治療 招待

    伊達 勲

    理学療法ジャーナル   55 ( 3 )   299 - 303   2021年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 特発性正常圧水頭症を知る 招待

    伊達 勲

    理学療法ジャーナル   55 ( 3 )   299 - 303   2021年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 脳出血 招待

    平松匡文、春間 純、菱川朋人、杉生憲志、伊達 勲

    脳神経外科   49 ( 2 )   284 - 292   2021年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • [Intracerebral Hemorrhage].

    Masafumi Hiramatsu, Jun Haruma, Tomohito Hishikawa, Kenji Sugiu, Isao Date

    No shinkei geka. Neurological surgery   49 ( 2 )   284 - 292   2021年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    CT angiography(CTA)plays a crucial role in the diagnosis of intracerebral hemorrhage(ICH). An 85-year-old woman presented with a disturbance of consciousness and right hemiparesis. Non-contrast CT of the brain revealed intracerebral hemorrhage in the left thalamus spreading to the internal capsule, corona radiata, and midbrain and a "swirl sign." CTA revealed no vascular anomaly. The early and delayed CTA phases revealed the"spot sign" and "leakage sign," respectively. Non-contrast CT three hours after the initial CT showed the enlargement of the hematoma. After the detection of ICH by initial non-contrast CT, CTA should be performed to differentiate between the causes of secondary ICH and detect the imaging markers of hematoma expansion or rebleeding. Previous studies have demonstrated that the "spot sign" detected by CTA is a valid imaging marker for hematoma expansion. In this article, the differential diagnosis of ICH and the detection of the imaging markers of hematoma expansion using non-contrast CT and CTA have been discussed.

    DOI: 10.11477/mf.1436204390

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  • Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration. 国際誌

    Atsuhito Uneda, Kazuhiko Kurozumi, Atsushi Fujimura, Kentaro Fujii, Joji Ishida, Yosuke Shimazu, Yoshihiro Otani, Yusuke Tomita, Yasuhiko Hattori, Yuji Matsumoto, Nobushige Tsuboi, Keigo Makino, Shuichiro Hirano, Atsunori Kamiya, Isao Date

    Acta neuropathologica communications   9 ( 1 )   29 - 29   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Glioblastoma (GBM) is the most lethal primary brain tumor characterized by significant cellular heterogeneity, namely tumor cells, including GBM stem-like cells (GSCs) and differentiated GBM cells (DGCs), and non-tumor cells such as endothelial cells, vascular pericytes, macrophages, and other types of immune cells. GSCs are essential to drive tumor progression, whereas the biological roles of DGCs are largely unknown. In this study, we focused on the roles of DGCs in the tumor microenvironment. To this end, we extracted DGC-specific signature genes from transcriptomic profiles of matched pairs of in vitro GSC and DGC models. By evaluating the DGC signature using single cell data, we confirmed the presence of cell subpopulations emulated by in vitro culture models within a primary tumor. The DGC signature was correlated with the mesenchymal subtype and a poor prognosis in large GBM cohorts such as The Cancer Genome Atlas and Ivy Glioblastoma Atlas Project. In silico signaling pathway analysis suggested a role of DGCs in macrophage infiltration. Consistent with in silico findings, in vitro DGC models promoted macrophage migration. In vivo, coimplantation of DGCs and GSCs reduced the survival of tumor xenograft-bearing mice and increased macrophage infiltration into tumor tissue compared with transplantation of GSCs alone. DGCs exhibited a significant increase in YAP/TAZ/TEAD activity compared with GSCs. CCN1, a transcriptional target of YAP/TAZ, was selected from the DGC signature as a candidate secreted protein involved in macrophage recruitment. In fact, CCN1 was secreted abundantly from DGCs, but not GSCs. DGCs promoted macrophage migration in vitro and macrophage infiltration into tumor tissue in vivo through secretion of CCN1. Collectively, these results demonstrate that DGCs contribute to GSC-dependent tumor progression by shaping a mesenchymal microenvironment via CCN1-mediated macrophage infiltration. This study provides new insight into the complex GBM microenvironment consisting of heterogeneous cells.

    DOI: 10.1186/s40478-021-01124-7

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  • Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus (Third Edition): Endorsed by the Japanese Society of Normal Pressure Hydrocephalus.

    Madoka Nakajima, Shigeki Yamada, Masakazu Miyajima, Kazunari Ishii, Nagato Kuriyama, Hiroaki Kazui, Hideki Kanemoto, Takashi Suehiro, Kenji Yoshiyama, Masahiro Kameda, Yoshinaga Kajimoto, Mitsuhito Mase, Hisayuki Murai, Daisuke Kita, Teruo Kimura, Naoyuki Samejima, Takahiko Tokuda, Mitsunobu Kaijima, Chihiro Akiba, Kaito Kawamura, Masamichi Atsuchi, Yoshihumi Hirata, Mitsunori Matsumae, Makoto Sasaki, Fumio Yamashita, Shigeki Aoki, Ryusuke Irie, Hiroji Miyake, Takeo Kato, Etsuro Mori, Masatsune Ishikawa, Isao Date, Hajime Arai

    Neurologia medico-chirurgica   61 ( 2 )   63 - 97   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Among the various disorders that manifest with gait disturbance, cognitive impairment, and urinary incontinence in the elderly population, idiopathic normal pressure hydrocephalus (iNPH) is becoming of great importance. The first edition of these guidelines for management of iNPH was published in 2004, and the second edition in 2012, to provide a series of timely, evidence-based recommendations related to iNPH. Since the last edition, clinical awareness of iNPH has risen dramatically, and clinical and basic research efforts on iNPH have increased significantly. This third edition of the guidelines was made to share these ideas with the international community and to promote international research on iNPH. The revision of the guidelines was undertaken by a multidisciplinary expert working group of the Japanese Society of Normal Pressure Hydrocephalus in conjunction with the Japanese Ministry of Health, Labour and Welfare research project. This revision proposes a new classification for NPH. The category of iNPH is clearly distinguished from NPH with congenital/developmental and acquired etiologies. Additionally, the essential role of disproportionately enlarged subarachnoid-space hydrocephalus (DESH) in the imaging diagnosis and decision for further management of iNPH is discussed in this edition. We created an algorithm for diagnosis and decision for shunt management. Diagnosis by biomarkers that distinguish prognosis has been also initiated. Therefore, diagnosis and treatment of iNPH have entered a new phase. We hope that this third edition of the guidelines will help patients, their families, and healthcare professionals involved in treating iNPH.

    DOI: 10.2176/nmc.st.2020-0292

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  • Osseous arteriovenous fistulas in the dorsum sellae, clivus, and condyle. 国際誌

    Masafumi Hiramatsu, Kenji Sugiu, Jun Haruma, Tomohito Hishikawa, Yu Takahashi, Satoshi Murai, Kazuhiko Nishi, Yoko Yamaoka, Isao Date

    Neuroradiology   63 ( 1 )   133 - 140   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: Arteriovenous fistulas (AVFs) located in the cavernous sinus (CS), clivus, and condyle can be osseous shunts in nature. Here, we reviewed the angioarchitecture, clinical characteristics, and treatment results of AVFs in these lesions. METHODS: Twenty-five patients with 27 lesions who underwent rotational angiography in our department between May 2013 and December 2019 were reviewed. We examined 20 CS AVFs, 2 clival AVFs, and 5 condylar AVFs. We divided the anatomical shunted pouches into five locations: the dorsum sellae (posteromedial of the CS), posterolateral wall of the CS, lateral wall of the CS, clivus, and condyle. We divided the AVFs into three categories: intraosseous, transitional, and nonosseous shunts. We analyzed the characteristics and treatment results. RESULTS: A total of 33 shunted pouches or points were identified in 27 lesions. The dorsum sellae (n = 16) was the most frequent location. Fourteen AVFs (88%) in the dorsum sellae were osseous (intraosseous or transitional) shunts. All AVFs in the clivus or condyle were also osseous shunts. Eleven lesions (92%) of intraosseous and all lesions of transitional shunts exhibited bilateral external carotid artery involvement as feeders. Ten lesions (83%) of intraosseous shunts were treated with selective transvenous embolization of the shunted pouch with or without additional partial embolization of the sinus. Eleven (92%) intraosseous shunts were completely occluded, and symptom resolution was achieved in all intraosseous shunts. CONCLUSION: Most of the CS AVFs with shunted pouches in the dorsum sellae and all of the AVFs in the clivus and condyle share similar characteristics.

    DOI: 10.1007/s00234-020-02506-9

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  • Chiari奇形1型の手術におけるデュラウェーブRを用いた硬膜形成

    冨田陽介、守本 純、佐々田晋、井本良二、馬越通有、金 恭平、亀田雅博、安原隆雄、伊達 勲

    脊髄外科 SPINAL SURGERY   34 ( 3 )   317 - 319   2020年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Dural arteriovenous fistulas in the parasellar region other than the cavernous sinus 査読 国際誌

    Hiramatsu M, Sugiu K, Haruma J, Hishikawa T, Takahashi Y, Murai S, Nishi K, Yamaoka Y, Date I

    Journal of Neuroendovascular Therapy   14 ( 12 )   593 - 604   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • FDG-PETと馬尾生検により早期診断し得た神経悪性リンパ腫症の1例 査読

    佐々木諒、太田康之、安原隆雄、伊達 勲、阿部康二

    CI研究   42 ( 2 )   127 - 130   2020年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Arteriovenous Fistula at the Craniocervical Junction Found After Cervical Laminoplasty for Ossification of the Posterior Longitudinal Ligament. 国際誌

    Susumu Sasada, Masafumi Hiramatsu, Akira Kusumegi, Haruto Fujimura, Shogo Oshikata, Yuichi Takahashi, Kenki Nishida, Takao Yasuhara, Isao Date

    Neurospine   17 ( 4 )   947 - 953   2020年12月

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    記述言語:英語  

    Ossification of the posterior longitudinal ligament (OPLL) is common in East Asia. Arteriovenous fistula at the craniocervical junction (CCJ-AVF), in contrast, is rare. As OPLL occurs most often in the cervical region, these 2 conditions can coexist in the cervical spinal canal of a single patient. We report a case of CCJ-AVF found after cervical laminoplasty (CLP) for OPLL. A 68-year-old man experienced progressive myelopathy due to cervical OPLL. Magnetic resonance imaging (MRI) revealed a high-intensity area inside the spinal cord. CLP was performed and his symptoms immediately improved. Three months after CLP, however, myelopathy recurred. MRI revealed an exacerbated and enlarged high-intensity area inside the cord from the medulla oblongata to the C4/5 level with a flow void around the cord. Left vertebral artery angiography revealed CCJ-AVF with ascending and descending draining veins. Direct surgery was performed to interrupt shunt flow into the draining veins. The patient's symptoms improved to a limited degree. In this case, increased pressure inside the spinal canal due to OPLL might have decreased the shunt flow of the CCJ-AVF. Thus, the venous congestion induced by CCJ-AVF might have been exacerbated after the pressure was removed by CLP. Magnetic resonance angiography screening could help detect concurrent CCJ-AVF and OPLL.

    DOI: 10.14245/ns.2040200.100

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  • 脳・神経疾患における再生医療の最前線 招待 査読

    安原隆雄、伊達 勲

    Precision Medicine   3 ( 11 )   980 - 983   2020年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 両側びまん性脈絡叢過形成の1例─両側びまん性脈絡叢過形成、両側脈絡叢乳頭腫に対する外科的治療に関する文献的レビュー─ 査読

    胡谷侑貴、安原隆雄、亀田雅博、福原 徹、伊達 勲

    脳神経外科ジャーナル   29 ( 10 )   726 - 734   2020年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Detailed Arterial Anatomy and Its Anastomoses of the Sphenoid Ridge and Olfactory Groove Meningiomas with Special Reference to the Recurrent Branches from the Ophthalmic Artery. 国際誌

    M Hiramatsu, K Sugiu, T Hishikawa, J Haruma, Y Takahashi, S Murai, K Nishi, Y Yamaoka, Y Shimazu, K Fujii, M Kameda, K Kurozumi, I Date

    AJNR. American journal of neuroradiology   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND AND PURPOSE: Detailed arterial anatomy of the sphenoid ridge and olfactory groove meningiomas is complicated due to the fine angioarchitecture and anastomoses between each feeder. Herein, we present details of the arterial anatomy and the relationships of feeders in these lesions. MATERIALS AND METHODS: This study included 20 patients admitted to our department between April 2015 and March 2020. Conditions of subjects consisted of 16 sphenoid ridge meningiomas and 4 olfactory groove meningiomas. We mainly analyzed arterial anatomy using 3D rotational angiography and slab MIP images of these lesions. We also analyzed the anastomoses of each feeder. RESULTS: We found that 19 (95%), 15 (75%), and 15 (75%) lesions had feeders from the ophthalmic, internal carotid, and external carotid arteries, respectively. As feeders from the ophthalmic artery, recurrent meningeal arteries were involved in 18 lesions (90%). Fifteen lesions (75%) had anastomoses between each feeder. CONCLUSIONS: Most of the meningiomas in the sphenoid ridge and olfactory groove had feeders from the ophthalmic and internal carotid arteries. There were various anastomoses between each feeder. This is the first report to demonstrate the detailed arterial anatomy and frequency of recurrent branches from the ophthalmic artery and their anastomoses using detailed imaging techniques.

    DOI: 10.3174/ajnr.A6790

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  • Detection of the common origin of the radiculomedullary artery with the feeder of spinal dural arteriovenous fistula using slab maximum intensity projection image. 国際誌

    Masafumi Hiramatsu, Kenji Sugiu, Takao Yasuhara, Tomohito Hishikawa, Jun Haruma, Yu Takahashi, Satoshi Murai, Kazuhiko Nishi, Yoko Yamaoka, Isao Date

    Neuroradiology   62 ( 10 )   1285 - 1292   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: Endovascular therapy to the spinal dural arteriovenous fistula (SDAVF) with a common origin of the radiculomedullary artery and the feeder of the shunt has the risk of spinal cord infarction. This study aimed to retrospectively assess the detection rate of normal spinal arteries from the feeder of SDAVF. METHODS: We retrospectively collected the angiographic and clinical data of SDAVFs. This study included 19 patients with 20 SDAVF lesions admitted to our department between January 2007 and December 2018. We assessed the detection rate of normal radiculomedullary artery branched from the feeder of SDAVF between the period using the image intensifier (II) and flat panel detector (FPD) and evaluated the treatment results. RESULTS: The detection rates of the radiculomedullary artery branched from the feeder of SDAVF were 10% (1/10 lesions) during the II period and 30% (3/10 lesions) during the FPD period. During the FPD period, all normal radiculomedullary arteries branched from the feeder were only detected on slab maximum intensity projection (MIP) images of rotational angiography, and we could not detect them in 2D or 3D digital subtraction angiography. All lesions that had a common origin of a normal radiculomedullary artery and the feeder were completely obliterated without complications. There was no recurrence during the follow-up period. CONCLUSIONS: The flat panel detector and slab MIP images seem to show the common origin of the normal radiculomedullary arteries from the feeder more accurately. With detailed analyses, SDAVF can be safety treated.

    DOI: 10.1007/s00234-020-02466-0

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  • 頭蓋内腫瘍塞栓術の役割と可能性 招待

    杉生憲志、菱川朋人、平松匡文、春間 純、西廣真吾、木谷尚哉、高橋 悠、村井 智、西 和彦、山岡陽子、胡谷侑貴、佐藤 悠、藤井謙太郎、伊達 勲

    脳神経外科ジャーナル   29 ( 8 )   543 - 551   2020年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 脳神経領域の意義とやりがい─神経科学に必要な知識・技術・夢─特別座談会 招待

    阿部康二、伊達 勲、山下 徹、杉生憲志、小笠原邦昭

    脳神経外科速報   30 ( 8 )   808 - 818   2020年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 分化型膠芽腫細胞はCCN1の分泌を介して腫瘍微小環境を改変する

    畝田 篤仁, 黒住 和彦, 藤村 篤史, 藤井 謙太郎, 島津 洋介, 松本 悠司, 坪井 伸成, 牧野 圭悟, 神谷 厚範, 伊達 勲

    Brain Tumor Pathology   37 ( Suppl. )   092 - 092   2020年8月

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    記述言語:日本語   出版者・発行元:日本脳腫瘍病理学会  

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  • 頭蓋内mesenchymal chondrosarcomaの1例

    牧野 圭悟, 畝田 篤仁, 黒住 和彦, 藤井 謙太郎, 島津 洋介, 松本 悠司, 坪井 伸成, 柳井 広之, 廣瀬 隆則, 伊達 勲

    Brain Tumor Pathology   37 ( Suppl. )   139 - 139   2020年8月

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    記述言語:日本語   出版者・発行元:日本脳腫瘍病理学会  

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  • ARHGEF2-NTRK1融合遺伝子を有する高悪性度グリア神経細胞腫瘍の1例

    坪井 伸成, 黒住 和彦, 中野 嘉子, 鷲尾 佳奈, 嶋田 明, 吉田 朗彦, 河野 隆志, 市村 幸一, 柳井 広之, 伊達 勲

    Brain Tumor Pathology   37 ( Suppl. )   128 - 128   2020年8月

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    記述言語:日本語   出版者・発行元:日本脳腫瘍病理学会  

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  • 分化型膠芽腫細胞はCCN1の分泌を介して腫瘍微小環境を改変する

    畝田 篤仁, 黒住 和彦, 藤村 篤史, 藤井 謙太郎, 島津 洋介, 松本 悠司, 坪井 伸成, 牧野 圭悟, 神谷 厚範, 伊達 勲

    Brain Tumor Pathology   37 ( Suppl. )   092 - 092   2020年8月

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    記述言語:日本語   出版者・発行元:日本脳腫瘍病理学会  

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  • ARHGEF2-NTRK1融合遺伝子を有する高悪性度グリア神経細胞腫瘍の1例

    坪井 伸成, 黒住 和彦, 中野 嘉子, 鷲尾 佳奈, 嶋田 明, 吉田 朗彦, 河野 隆志, 市村 幸一, 柳井 広之, 伊達 勲

    Brain Tumor Pathology   37 ( Suppl. )   128 - 128   2020年8月

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    記述言語:日本語   出版者・発行元:日本脳腫瘍病理学会  

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  • Japanese National Questionnaire Survey in 2018 on Complications Related to Cranial Implants in Neurosurgery.

    Takao Yasuhara, Satoshi Murai, Nobuhiro Mikuni, Susumu Miyamoto, Isao Date

    Neurologia medico-chirurgica   60 ( 7 )   337 - 350   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Cranial implants are commonly used throughout the world, yet the data on complications remain partly clarified. The aim of this study was to gather real data in 2018 on complications related to cranial implants in neurosurgery. The survey population consisted of 1103 institutes supplying neurosurgical treatment. The survey consisted of two-stage questionnaire. First the incidence of complications was investigated, then the secondary questionnaire was e-mailed to the respondents about the detailed of the complications. As the result, the annual incidence of complications related to cranial implants was 0.558% in Japan. Titanium plate and mesh were used predominantly in craniotomy and cranioplasty, respectively. The second survey collected data on 449 cases with complications (infection: 63%, implant exposure: 46%, multiple answer). Postoperative infection was associated with male sex, brain tumor, short interval between surgery and complication, usage of ceramics, hydroxyapatite, resin, and artificial dura, hyponutrition, multiple surgeries, dirty wound, and sinusitis as patient factors, and CSF leakage, ruptured sutures, and sinus maltreatment as surgery factors. Meanwhile, long hospital stay was associated with age, male sex, mRS 3-5 before complication, short interval between initial surgery and complication, large craniotomy, long operative time, usage of ceramics and artificial dura, multiple surgeries and dirty wound as patient factors, ruptured suture as a surgical factor, and bacterial infection, especially MRSA infection, as the complication and treatment consisting of removal as complication factors. In conclusion, this is the first Japanese national survey on complications related to cranial implants in neurosurgery. It is important to recall that complications may arise years after surgery and to be aware of the risk factors associated with complications.

    DOI: 10.2176/nmc.oa.2020-0051

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  • Primary Central Nervous System Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis: Case Report and Review of Literature.

    Atsuhito Uneda, Koji Hirashita, Takahiro Kanda, Masatoshi Yunoki, Kimihiro Yoshino, Kazuhiko Kurozumi, Isao Date

    NMC case report journal   7 ( 3 )   121 - 127   2020年7月

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    記述言語:英語  

    Methotrexate (MTX) is an immunosuppressor that is widely used to treat autoimmune diseases, including rheumatoid arthritis (RA). However, it can have serious adverse effects including a lymphoma: MTX-associated lymphoproliferative disorder (MTX-LPD). Extranodal lesions are common in MTX-LPD patients. However, MTX-LPD in the central nervous system (CNS) is extremely rare with few reported cases. Here, we describe a case of primary CNS MTX-LPD in a patient with RA, with a review of the literature. A 68-year-old woman who had received MTX for her RA for more than 10 years was referred to our hospital. Head magnetic resonance imaging (MRI) showed multiple lesions with heterogeneous contrast enhancement scattered throughout both hemispheres. As immunosuppression caused by MTX was suspected, MTX was discontinued, based on a working diagnosis of MTX-LPD. We performed an open biopsy of her right temporal lesion. Histopathologic examination showed atypical CD20+ lymphoid cells, leading to a definitive diagnosis of diffuse large B-cell lymphoma (DLBCL). In situ hybridization of an Epstein-Barr virus-encoded small RNA (EBER) was positive. Sanger sequencing confirmed that both MYD88 L265 and CD79B Y196 mutations were absent. The LPD regressed after stopping MTX. Follow-up head MRI at 8 months after surgery showed no evidence of recurrence. Although primary CNS MTX-LPD is extremely rare, it should be included in the differential diagnosis when a patient receiving MTX develops CNS lesions. Diagnosis by biopsy and MTX discontinuation are required as soon as possible.

    DOI: 10.2176/nmccrj.cr.2019-0241

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  • Cerebellar Blood Flow and Gene Expression in Crossed Cerebellar Diaschisis after Transient Middle Cerebral Artery Occlusion in Rats. 国際誌

    Naoya Kidani, Tomohito Hishikawa, Masafumi Hiramatsu, Shingo Nishihiro, Kyohei Kin, Yu Takahashi, Satoshi Murai, Kenji Sugiu, Takao Yasuhara, Ikuko Miyazaki, Masato Asanuma, Isao Date

    International journal of molecular sciences   21 ( 11 )   2020年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Crossed cerebellar diaschisis (CCD) is a state of hypoperfusion and hypometabolism in the contralesional cerebellar hemisphere caused by a supratentorial lesion, but its pathophysiology is not fully understood. We evaluated chronological changes in cerebellar blood flow (CbBF) and gene expressions in the cerebellum using a rat model of transient middle cerebral artery occlusion (MCAO). CbBF was analyzed at two and seven days after MCAO using single photon emission computed tomography (SPECT). DNA microarray analysis and western blotting of the cerebellar cortex were performed and apoptotic cells in the cerebellar cortex were stained. CbBF in the contralesional hemisphere was significantly decreased and this lateral imbalance recovered over one week. Gene set enrichment analysis revealed that a gene set for "oxidative phosphorylation" was significantly upregulated while fourteen other gene sets including "apoptosis", "hypoxia" and "reactive oxygen species" showed a tendency toward upregulation in the contralesional cerebellum. MCAO upregulated the expressions of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) in the contralesional cerebellar cortex. The number of apoptotic cells increased in the molecular layer of the contralesional cerebellum. Focal cerebral ischemia in our rat MCAO model caused CCD along with enhanced expression of genes related to oxidative stress and apoptosis.

    DOI: 10.3390/ijms21114137

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  • Cell therapy for central nervous system disorders: Current obstacles to progress. 査読 国際誌

    Takao Yasuhara, Satoshi Kawauchi, Kyohei Kin, Jun Morimoto, Masahiro Kameda, Tatsuya Sasaki, Brooke Bonsack, Chase Kingsbury, Naoki Tajiri, Cesario V Borlongan, Isao Date

    CNS neuroscience & therapeutics   26 ( 6 )   595 - 602   2020年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Cell therapy for disorders of the central nervous system has progressed to a new level of clinical application. Various clinical studies are underway for Parkinson's disease, stroke, traumatic brain injury, and various other neurological diseases. Recent biotechnological developments in cell therapy have taken advantage of the technology of induced pluripotent stem (iPS) cells. The advent of iPS cells has provided a robust stem cell donor source for neurorestoration via transplantation. Additionally, iPS cells have served as a platform for the discovery of therapeutics drugs, allowing breakthroughs in our understanding of the pathology and treatment of neurological diseases. Despite these recent advances in iPS, adult tissue-derived mesenchymal stem cells remain the widely used donor for cell transplantation. Mesenchymal stem cells are easily isolated and amplified toward the cells' unique trophic factor-secretion property. In this review article, the milestone achievements of cell therapy for central nervous system disorders, with equal consideration on the present translational obstacles for clinic application, are described.

    DOI: 10.1111/cns.13247

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  • Correction to: High‑Mobility Group Box‑1‑Induced Angiogenesis After Indirect Bypass Surgery in a Chronic Cerebral Hypoperfusion Model. 国際誌

    Shingo Nishihiro, Tomohito Hishikawa, Masafumi Hiramatsu, Naoya Kidani, Yu Takahashi, Satoshi Murai, Kenji Sugiu, Yusuke Higaki, Takao Yasuhara, Cesario V Borlongan, Isao Date

    Neuromolecular medicine   22 ( 2 )   332 - 333   2020年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The original version of this article unfortunately contained a mistake. Figure 5a, b were incorrect. The correct figures are given below.

    DOI: 10.1007/s12017-020-08594-3

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  • 脊髄電気刺激は神経保護効果を有するか─パーキンソン病の再生医療─ 査読

    安原隆雄、守本 純、金 恭平、佐々木達也、伊達 勲

    脊髄外科 SPINAL SURGERY   34 ( 1 )   90 - 91   2020年4月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 術前Short Form-36は脊椎変性疾患術後せん妄発症を予測する 査読

    金 恭平、安原隆雄、守本 純、馬越通有、冨田陽介、伊達 勲

    脊髄外科 SPINAL SURGERY   34 ( 1 )   95 - 97   2020年4月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • The Japan Neurosurgical Database: Overview and Results of the First-year Survey.

    Koji Iihara, Teiji Tominaga, Nobuhito Saito, Michiyasu Suzuki, Isao Date, Yukihiko Fujii, Kazuhiro Hongo, Kiyohiro Houkin, Amami Kato, Yoko Kato, Takakazu Kawamata, Phyo Kim, Hiroyuki Kinouchi, Eiji Kohmura, Kaoru Kurisu, Keisuke Maruyama, Nobuhiro Mikuni, Susumu Miyamoto, Akio Morita, Hiroyuki Nakase, Yoshitaka Narita, Ryo Nishikawa, Kazuhiko Nozaki, Kuniaki Ogasawara, Kenji Ohata, Nobuyuki Sakai, Hiroaki Sakamoto, Yoshiaki Shiokawa, Yukihiko Sonoda, Jun C Takahashi, Keisuke Ueki, Toshihiko Wakabayashi, Takamitsu Yamamoto, Kazunari Yoshida, Takamasa Kayama, Hajime Arai

    Neurologia medico-chirurgica   60 ( 4 )   165 - 190   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The Japan Neurosurgical Database (JND) is a prospective observational study registry established in 2017 by the Japan Neurosurgical Society (JNS) to visualize real-world clinical practice, promote science, and improve the quality of care and neurosurgery board certification in Japan. We summarize JND's aims and methods, and describes the 2018 survey results. The JND registered in-hospital patients' clinical data mainly from JNS training institutions in 2018. Caseload, patient demographics, and in-hospital outcomes of the overall cohort and a neurosurgical subgroup were examined according to major classifications of main diagnosis. Neurosurgical caseload per neurosurgeon in training in core hospitals in 2018 was calculated as an indicator of neurosurgical training. Of 523,283 cases (male 55.3%) registered from 1360 participating institutions, the neurosurgical subgroup comprised of 33.9%. Among the major classifications, cerebrovascular diseases comprised the largest proportion overall and in the neurosurgical subgroup (53.1%, 41.0%, respectively), followed by neurotrauma (19.1%, 25.5%), and brain tumor (10.4%, 12.8%). Functional neurosurgery (6.4%, 3.7%), spinal and peripheral nerve disorders (5.1%, 10.1%), hydrocephalus/developmental anomalies (2.9%, 5.3%), and encephalitis/infection/inflammatory and miscellaneous diseases (2.9%, 1.6%) comprised smaller proportions. Most patients were aged 70-79 years in the overall cohort and neurosurgical subgroup (27.8%, 29.4%). Neurotrauma and cerebrovascular diseases in the neurosurgical subgroup comprised a higher and lower proportion, respectively, than in the overall cohort in elderly patients (e.g. 80 years, 46.9% vs. 33.5%, 26.8% vs. 54.4%). The 2018 median neurosurgical caseload per neurosurgeon in training was 80.7 (25-75th percentile 51.5-117.5). These initial results from 2018 reveal unique aspects of neurosurgical practice in Japan.

    DOI: 10.2176/nmc.st.2019-0211

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  • Intracranial Mesenchymal Chondrosarcoma Lacking the Typical Histopathological Features Diagnosed by HEY1-NCOA2 Gene Fusion. 査読

    Atsuhito Uneda, Kazuhiko Kurozumi, Atsushi Fujimura, Atsunori Kamiya, Takanori Hirose, Hiroyuki Yanai, Isao Date

    NMC case report journal   7 ( 2 )   47 - 52   2020年4月

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    記述言語:英語  

    Intracranial mesenchymal chondrosarcoma (MCS) is a rare neoplasm. The diagnosis of MCS is confirmed by the presence of a biphasic pattern on histological examination, comprising undifferentiated small round cells admixed with islands of well-differentiated hyaline cartilage; however, a differential diagnosis may be challenging in some cases. A 28-year-old woman with a 2-month history of headache was referred to our hospital. Radiologic studies showed an extra-axial lobulated mass composed of calcified and uncalcified areas occupying the left middle fossa. Surgical resection was planned, but her headache suddenly worsened before her planned hospital admission and she was admitted as an emergency. Radiologic studies showed an acute hemorrhage in the uncalcified part of the mass. The mass was resected via the left zygomatic approach after embolization of the feeder vessels. The most likely histopathological diagnosis was MCS. However, the typical bimorphic pattern was not identified in our surgical samples; each undifferentiated area and well-differentiated area was observed separately in different tissue specimens, and no islands of well-differentiated hyaline cartilage were identified within the undifferentiated areas in the same specimen. Molecular assays confirmed the presence of HEY1-NCOA2 fusion. IRF2BP2-CDX1 fusion and IDH1/2 mutations were negative. The final diagnosis of MCS was made based on the presence of HEY1-NCOA2 gene fusion. MCS should be included in the differential diagnosis when radiologic studies show an extra-axial lobulated mass with calcification. Furthermore, molecular demonstration of HEY1-NCOA2 gene fusion may help make a precise diagnosis of MCS, especially in surgical samples lacking the typical histopathological features.

    DOI: 10.2176/nmccrj.cr.2019-0123

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  • Safety and efficacy of staged angioplasty for patients at risk of hyperperfusion syndrome: a single-center retrospective study. 国際誌

    Satoshi Murai, Kenji Sugiu, Tomohito Hishikawa, Masafumi Hiramatsu, Shingo Nishihiro, Naoya Kidani, Yu Takahashi, Kazuhiko Nishi, Yoko Yamaoka, Isao Date

    Neuroradiology   62 ( 4 )   503 - 510   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: Intracranial hemorrhage following hyperperfusion syndrome (HPS) is a rare but potentially fatal complication after carotid artery stenting (CAS). Staged angioplasty (SAP) is a two-stage form of CAS that can prevent the abrupt increase of cerebral blood flow. In this study, we investigated the safety and efficacy of SAP. METHODS: One hundred thirty-four patients who underwent CAS for high-grade carotid artery stenosis between January 2010 and December 2018 were enrolled. Patients who showed severe impairment of hemodynamic reserve in 123I-IMP SPECT with acetazolamide received SAP (SAP group), while the others received regular CAS (RS group). RESULTS: Twenty-six (19.4%) patients at risk for HPS received SAP. HPS was not observed in either group. Diffusion-weighted image (DWI)-positive lesions on postoperative MRI were observed in 56 (52.3%) cases in the RS group and 16 (64.0%) cases in the SAP group. Symptomatic procedure-related complications occurred in 5 (4.6%) cases in the RS group and 1 (3.8%) case in the SAP group. These differences were not statistically significant. Modified Rankin Scale score had declined 30 days after discharge in 4 (3.0%) cases. Distal filter protection was significantly correlated to the occurrence of new DWI-positive lesions. CONCLUSIONS: For patients at high risk of HPS, SAP was a reasonable treatment strategy to prevent HPS. SAP did not increase the rate of DWI-positive lesions or procedure-related complications compared with regular CAS.

    DOI: 10.1007/s00234-019-02343-5

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  • A register-based SAH study in Japan: high incidence rate and recent decline trend based on lifestyle. 国際誌

    Fusao Ikawa, Akio Morita, Takeo Nakayama, Yoshihito Goto, Nobuyuki Sakai, Koji Iihara, Yoshiaki Shiokawa, Isao Date, Kazuhiko Nozaki, Hiroyuki Kinouchi, Kiyohiro Houkin, Nobuhito Saito, Teiji Tominaga, Michiyasu Suzuki, Susumu Miyamoto, Kaoru Kurisu, Hajime Arai

    Journal of neurosurgery   1 - 9   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: Japan has been reported to have the highest (and increasing) incidence of subarachnoid hemorrhage (SAH) in the world. However, there has never been a report on the nationwide incidence rate and recent trends for SAH in Japan. In this register-based study, the authors aimed to clarify the estimated nationwide SAH incidence rate and the recent trend in SAH incidence in Japan and the reasons for any changes in this trend. METHODS: The authors compiled data from the Japanese Ministry of Health, Labour and Welfare and from the records of the Japan Neurosurgical Society. They reviewed the age-standardized nationwide SAH mortality rate, the estimated age-standardized SAH incidence rate according to the age-standardized SAH mortality rate, and the estimated crude SAH incidence rate, including the 95% confidence intervals, from 2003 to 2015. The trends in the number of treatments for unruptured and ruptured cerebral aneurysms, as well as the prevalence of hypertension, current smoking status, and use of cholesterol-lowering drugs, were assessed. The estimated treatment rate for unruptured cerebral aneurysms (UCAs) was also calculated along with the 95% confidence interval. RESULTS: The estimated age-standardized nationwide SAH incidence rate significantly declined from 31.34 cases (95% CI 31.32-31.34) to 27.63 (95% CI 27.59-27.63; decrease by 11.8%) per 100,000 person-years. This decline was based on the 2010 population as the reference from 2003 through 2015 and a case-fatality rate of SAH that was assumed to decrease by 1% annually from 44% in 2003 to 32% in 2015. According to sensitivity analysis, the change rate of the estimated age-standardized SAH incidence rate ranged from -56.69% to 23.27%, with a mean of -30.91% (SD 20.52%), and there were decline trends in 92% of all trends. The estimated nationwide crude SAH incidence rate also showed a significant decline from 23.79 (95% CI 23.78-23.79) to 20.25 (95% CI 20.24-20.25; decrease by 14.9%) per 100,000 person-years. The trend in treatment numbers for UCAs increased significantly (p < 0.0001) from 2003 through 2015; however, the estimated treatment rate for UCAs was only 0.19 (95% CI 0.19-0.20) to 0.51 (95% CI 0.50-0.51) among all UCA patients. The prevalence of hypertension (males, p = 0.0003; females, p < 0.0001) and current smoking status (males, p < 0.0001; females, p = 0.0002) declined significantly from 2003 through 2015, while the use of cholesterol-lowering drugs increased significantly (males, p < 0.0001; females, p = 0.0005) during the same period. CONCLUSIONS: The estimated nationwide SAH incidence rate in Japan was higher than rates in other countries, although it has declined recently. An improving lifestyle may have contributed to the declining rate of SAH incidence in Japan.

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  • A unique case with positive anti-myelin oligodendrocyte glycoprotein antibody presenting multiple brain lesions

    Namiko Matsumoto, Kota Sato, Nozomi Hishikawa, Yuko Kawahara, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Kentaro Fujii, Kazuhiko Kurozumi, Isao Date, Toshiyuki Takahashi, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   8 ( 2 )   92 - 95   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    The accurate diagnosis of anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated diseases is sometimes challenging due to its various central nervous system (CNS) lesions. Here, we report a 22-year-old man with positive anti-MOG antibody presenting multiple brain lesions including a brainstem tumefactive demyelinating lesion (TDL), cortical edematous lesions, and a periventricular white matter lesion. These variety of lesions made the diagnosis challenging, especially because TDL is quite rare among MOG antibody-associated disease patients. The present case suggests the importance to check anti-MOG antibody for patients presenting atypical multiple CNS lesions.

    DOI: 10.1111/ncn3.12364

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  • Precise MEP monitoring with a reduced interval is safe and useful for detecting permissive duration for temporary clipping. 国際誌

    Masahiro Kameda, Tomohito Hishikawa, Masafumi Hiramatsu, Takao Yasuhara, Kazuhiko Kurozumi, Isao Date

    Scientific reports   10 ( 1 )   3507 - 3507   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Although temporary clipping of the parent artery is an indispensable technique in clipping surgery for intracranial aneurysms, the permissive duration of temporary clipping is still not well known. The aim of this study is to confirm the safety of precise motor evoked potential (MEP) monitoring and to estimate the permissive duration of temporary clipping for middle cerebral artery (MCA) aneurysm based on precise MEP monitoring results. Under precise MEP monitoring via direct cortical stimulation every 30 seconds to 1 minute, surgeons released a temporary clip and waited for MEP amplitude to recover following severe (>50%) reduction of MEP amplitude during temporary clipping. Precise MEP monitoring was safely performed. Twenty-eight instances of temporary clipping were performed in 42 MCA aneurysm clipping surgeries. Because precise MEP monitoring could be used to determine when to release a temporary clip even with a severe reduction in MEP amplitude due to lengthy temporary clipping, no patients experienced permanent postoperative hemiparesis. Based on logistic regression analysis, if a temporary clip is applied for 312 seconds or more, there is a higher probability of a severe reduction in MEP amplitude. We should therefore release temporary clips after 5 minutes in order to avoid permanent postoperative hemiparesis.

    DOI: 10.1038/s41598-020-60377-9

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  • 脳血管攣縮に対する薬物療法と髄液管理の治療成績 招待

    菱川朋人、村井 智、高橋 悠、木谷尚哉、平松匡文、杉生憲志、伊達 勲

    脳血管攣縮   35   16 - 19   2020年2月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Corrigendum to 'Prosthesis Used in Microvascular Decompressions: A Multicenter Survey in Japan Focusing on Adverse Events' [World Neurosurgery 130 (2019) e251-e258]. 査読 国際誌

    Mitsuhiro Hasegawa, Toru Hatayama, Akinori Kondo, Shinji Nagahiro, Takamitsu Fujimaki, Kenichi Amagasaki, Kazunori Arita, Isao Date, Yukihiko Fujii, Takeo Goto, Ryosuke Hanaya, Yoshinori Higuchi, Kazuhiro Hongo, Toru Inoue, Hidetoshi Kasuya, Takamasa Kayama, Masatou Kawashima, Eiji Kohmura, Taketoshi Maehara, Toshio Matsushima, Yoshihumi Mizobuchi, Akio Morita, Shigeru Nishizawa, Shusaku Noro, Shinjiro Saito, Hirofumi Shimano, Reizo Shirane, Hideo Takeshima, Yuichiro Tanaka, Hidenori Tanabe, Hiroki Toda, Iwao Yamakami, Yuya Nishiyama, Shigeo Ohba, Yuichi Hirose, Takeya Suzuki

    World neurosurgery   134   685 - 685   2020年2月

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  • Study protocol of a Phase I/IIa clinical trial of Ad-SGE-REIC for treatment of recurrent malignant glioma. 国際誌

    Kazuhiko Kurozumi, Kentaro Fujii, Yosuke Shimazu, Yusuke Tomita, Tatsuya Sasaki, Takao Yasuhara, Tomohito Hishikawa, Masahiro Kameda, Hiromi Kumon, Isao Date

    Future oncology (London, England)   16 ( 6 )   151 - 159   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Malignant glioma is one of the most common brain cancers in humans, which is very devastating. The expression of reduced expression in immortalized cells/Dickkopf-3 (REIC/Dkk-3) is decreased in various human cancers. Lately, we have developed a novel second-generation adenoviral vector that expresses REIC/Dkk-3 (Ad-SGE-REIC) and revealed its antiglioma efficacy. The present investigator-initiated clinical trial is a single-arm, prospective, nonrandomized, noncomparative, open-label, single-center trial performed at Okayama University Hospital, Okayama, Japan. The primary end points are dose-limiting toxicities and the incidence of adverse events. The secondary end points are the objective response rate and immunological assessment. Use of Ad-SGE-REIC will help to improve the prognosis of patients with malignant brain tumors.

    DOI: 10.2217/fon-2019-0743

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  • 経時的3DDSA fusion画像で仮性動脈瘤の位置を同定しtarget embolizationを行い得た破裂AVMの1例 査読

    村井 智、杉生憲志、菱川朋人、平松匡文、西廣真吾、木谷尚哉、高橋 悠、伊達 勲

    脳神経外科速報   48 ( 1 )   39 - 45   2020年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • [A Case of Ruptured Arteriovenous Malformation Successfully Treated with Target Embolization for Pseudoaneurysm Detected Using Chronological Three-dimensional Digital Subtraction Angiography Fusion Images].

    Satoshi Murai, Kenji Sugiu, Tomohito Hishikawa, Masafumi Hiramatsu, Shingo Nishihiro, Naoya Kidani, Yu Takahashi, Isao Date

    No shinkei geka. Neurological surgery   48 ( 1 )   39 - 45   2020年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    We herein report a case of ruptured arterio-venous malformation(AVM)detected using three-dimensional digital subtraction angiography(3DDSA)fusion images and successfully treated with target embolization for pseudoaneurysm. A 50-year-old man with a history of AVM was admitted to our department for the treatment of ruptured high-grade AVM in the right parietal lobe. Although a bleeding point was not evident on DSA, the patient had re-rupture in the right ventricle, one month after admission. Chronological 3DDSA fusion images generated from 3DDSA images taken on admission and after re-rupture revealed a newly visualized intranidal pseudoaneurysm near a hematoma. Contrast-enhanced magnetic resonance imaging showed vessel wall enhancement along the posterior horn of the right ventricle;this enhancement corresponded to the location of the pseudoaneurysm. We planned target embolization for the intranidal pseudoaneurysm to prevent re-bleeding. The origin of the feeder was so steep that a microcatheter could not be advanced deeply, and embolization with 20% n-butyl-2-cyanoacrylate resulted in proximal occlusion. Follow-up angiography 1 week after embolization showed complete disappearance of the pseudoaneurysm, and the patient had no recurrence of aneurysm until one year.

    DOI: 10.11477/mf.1436204131

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  • Metal artifact reduction algorithm for image quality improvement of cone-beam CT images of medium or large cerebral aneurysms treated with stent-assisted coil embolization. 国際誌

    Satoshi Murai, Masafumi Hiramatsu, Yuji Takasugi, Yu Takahashi, Naoya Kidani, Shingo Nishihiro, Yukei Shinji, Jun Haruma, Tomohito Hishikawa, Kenji Sugiu, Isao Date

    Neuroradiology   62 ( 1 )   89 - 96   2020年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: The aim of the present study was to assess image quality improvement using a metal artifact reduction (MAR) algorithm in cases of medium or large cerebral aneurysms treated with stent-assisted coil embolization (SAC), and to analyze factors associated with the usefulness of the MAR algorithm. METHODS: We retrospectively evaluated the cone-beam computed tomography (CBCT) data sets of 18 patients with cerebral aneurysms treated with SAC. For subjective analysis, images of all cases with and without MAR processing were evaluated by five neurosurgeons based on four criteria using a five-point scale. For objective analysis, the CT values of all cases with and without MAR processing were calculated. In addition, we assessed factors associated with the usefulness of the MAR by analyzing the nine cases in which the median score for criterion 1 improved by more than two points. RESULTS: MAR processing improved the median scores for all four criteria in 17/18 cases (94.4%). Mean CT values of the region of interest at the site influenced by metal artifacts were significantly reduced after MAR processing. The maximum diameter of the coil mass (< 17 mm; odds ratio [OR], 4.0; 95% confidence interval [CI], 1.2-13.9; p = 0.02) and vessel length covered by metal artifacts (< 24 mm; OR, 2.3; 95% CI, 1.1-4.7; p = 0.03) was significantly associated with the usefulness of the MAR. CONCLUSIONS: This study suggests the feasibility of a MAR algorithm to improve the image quality of CBCT images in patients who have undergone SAC for medium or large aneurysms.

    DOI: 10.1007/s00234-019-02297-8

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  • Effect of treatment modality and cerebral vasospasm agent on patient outcomes after aneurysmal subarachnoid hemorrhage in the elderly aged 75 years and older. 国際誌

    Keisuke Ido, Ryota Kurogi, Ai Kurogi, Kunihiro Nishimura, Koichi Arimura, Ataru Nishimura, Nice Ren, Akiko Kada, Ryu Matsuo, Daisuke Onozuka, Akihito Hagihara, So Takagishi, Keitaro Yamagami, Misa Takegami, Yasunobu Nohara, Naoki Nakashima, Masahiro Kamouchi, Isao Date, Takanari Kitazono, Koji Iihara

    PloS one   15 ( 4 )   e0230953   2020年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: We sought to examine whether the effect of treatment modality and drugs for cerebral vasospasm on clinical outcomes differs between elderly and non-elderly subarachnoid hemorrhage (SAH) patients in Japan. METHODS: We analyzed the J-ASPECT Study Diagnosis Procedure Combination database (n = 17,343) that underwent clipping or coiling between 2010 and 2014 in 579 hospitals. We stratified patients into two groups according to their age (elderly [≥75 years old], n = 3,885; non-elderly, n = 13,458). We analyzed the effect of treatment modality and anti-vasospasm agents (fasudil hydrochloride, ozagrel sodium, cilostazol, statin, eicosapentaenoic acid [EPA], and edaravone) on in-hospital poor outcomes (mRS 3-6 at discharge) and mortality using multivariable analysis. RESULTS: The elderly patients were more likely to be female, have impaired levels of consciousness and comorbidity, and less likely to be treated with clipping and anti-vasospasm agents, except for ozagrel sodium and statin. In-hospital mortality and poor outcomes were higher in the elderly (15.8% vs. 8.5%, 71.7% vs. 36.5%). Coiling was associated with higher mortality (odds ratio 1.43, 95% confidence interval 1.2-1.7) despite a lower proportion of poor outcomes (0.84, 0.75-0.94) in the non-elderly, in contrast to no effect on clinical outcomes in the elderly. A comparable effect of anti-vasospasm agents on mortality was observed between non-elderly and elderly for fasudil hydrochloride (non-elderly: 0.20, 0.17-0.24), statin (0.63, 0.50-0.79), ozagrel sodium (0.72, 0.60-0.86), and cilostazol (0.63, 0.51-0.77). Poor outcomes were inversely associated with fasudil hydrochloride (0.59, 0.51-0.68), statin (0.84, 0.75-0.94), and EPA (0.83, 0.72-0.94) use in the non-elderly. No effect of these agents on poor outcomes was observed in the elderly. CONCLUSIONS: In contrast to the non-elderly, no effect of treatment modality on clinical outcomes were observed in the elderly. A comparable effect of anti-vasospasm agents was observed on mortality, but not on functional outcomes, between the non-elderly and elderly.

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  • Encapsulation of Mesenchymal Stem Cells: Dissecting the Underlying Mechanism of Mesenchymal Stem Cell Transplantation Therapy. 国際誌

    Kyohei Kin, Takao Yasuhara, Isao Date

    Neuroscience insights   15   2633105520959064 - 2633105520959064   2020年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Mesenchymal stem cells (MSCs) are widely considered good candidates for cell transplantation therapy. Various central nervous system disorders have been suggested as suitable targets for MSC transplantation therapy. In this context, a great deal of basic and clinical research has been conducted to explore its clinical uses. Although depression is one of the most common diseases in the world, the response rate to the currently available treatment is insufficient and new treatments are much needed. Despite the fact that MSC transplantation therapy has the potential to elicit an antidepressant effect, few studies have been conducted on this topic to date and the underlying mechanism remains poorly understood. To address the development of a new treatment for depression, we evaluated the effect of MSCs using the encapsulation technique and Wistar-Kyoto rats. Encapsulation enables dissection of the complicated underlying mechanism of MSC transplantation therapy. Wistar-Kyoto rats that exhibit treatment-resistant depressive-like behaviors allow us to compare the effect of MSCs with that of conventional antidepressant treatment. In this commentary, we briefly summarize our recent published results and discuss future research prospects.

    DOI: 10.1177/2633105520959064

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  • Long-Term Continuous Cervical Spinal Cord Stimulation Exerts Neuroprotective Effects in Experimental Parkinson's Disease. 国際誌

    Ken Kuwahara, Tatsuya Sasaki, Takao Yasuhara, Masahiro Kameda, Yosuke Okazaki, Kakeru Hosomoto, Ittetsu Kin, Mihoko Okazaki, Satoru Yabuno, Satoshi Kawauchi, Yousuke Tomita, Michiari Umakoshi, Kyohei Kin, Jun Morimoto, Jea-Young Lee, Naoki Tajiri, Cesar V Borlongan, Isao Date

    Frontiers in aging neuroscience   12   164 - 164   2020年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background: Spinal cord stimulation (SCS) exerts neuroprotective effects in animal models of Parkinson's disease (PD). Conventional stimulation techniques entail limited stimulation time and restricted movement of animals, warranting the need for optimizing the SCS regimen to address the progressive nature of the disease and to improve its clinical translation to PD patients. Objective: Recognizing the limitations of conventional stimulation, we now investigated the effects of continuous SCS in freely moving parkinsonian rats. Methods: We developed a small device that could deliver continuous SCS. At the start of the experiment, thirty female Sprague-Dawley rats received the dopamine (DA)-depleting neurotoxin, 6-hydroxydopamine, into the right striatum. The SCS device was fixed below the shoulder area of the back of the animal, and a line from this device was passed under the skin to an electrode that was then implanted epidurally over the dorsal column. The rats were divided into three groups: control, 8-h stimulation, and 24-h stimulation, and behaviorally tested then euthanized for immunohistochemical analysis. Results: The 8- and 24-h stimulation groups displayed significant behavioral improvement compared to the control group. Both SCS-stimulated groups exhibited significantly preserved tyrosine hydroxylase (TH)-positive fibers and neurons in the striatum and substantia nigra pars compacta (SNc), respectively, compared to the control group. Notably, the 24-h stimulation group showed significantly pronounced preservation of the striatal TH-positive fibers compared to the 8-h stimulation group. Moreover, the 24-h group demonstrated significantly reduced number of microglia in the striatum and SNc and increased laminin-positive area of the cerebral cortex compared to the control group. Conclusions: This study demonstrated the behavioral and histological benefits of continuous SCS in a time-dependent manner in freely moving PD animals, possibly mediated by anti-inflammatory and angiogenic mechanisms.

    DOI: 10.3389/fnagi.2020.00164

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  • Neurosurgery for brain metastasis from breast cancer 査読 国際誌

    Tomita Y, Kurozumi K, Fujii K, Shimazu Y, Date I

    Translational Cancer Research   2020年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.21037/tcr.2020.03.68

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  • パーキンソン病モデルラットに対する持続脊髄電気刺激療法の有用性 査読

    桑原 研、佐々木達也、岡崎洋介、細本 翔、金 一徹、藪野 諭、河内 哲、冨田陽介、馬越通有、亀田雅博、安原隆雄、伊達 勲

    機能的脳神経外科   58   45 - 51   2019年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Huge abdominal cerebrospinal fluid pseudocyst following ventriculoperitoneal shunt: a case report. 国際誌

    Yasuhiro Koide, Takaaki Osako, Masahiro Kameda, Hiromi Ihoriya, Hirotsugu Yamamoto, Noritomo Fujisaki, Toshiyuki Aokage, Tetsuya Yumoto, Isao Date, Hiromichi Naito, Atsunori Nakao

    Journal of medical case reports   13 ( 1 )   361 - 361   2019年12月

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    記述言語:英語  

    INTRODUCTION: Abdominal pseudocysts comprising cerebrospinal fluid are an uncommon but significant complication in patients with ventriculoperitoneal shunt. We present a successfully treated 12-year-old boy with a history of ventriculoperitoneal shunting and a huge abdominal cerebrospinal fluid pseudocyst. CASE PRESENTATION: A12-year-old Japanese boy presented with a deteriorated consciousness and a palpable and elastic large lower abdominal mass. Computed tomography of his abdomen demonstrated a collection of homogenous low-density fluid near the catheter tip of the ventriculoperitoneal shunt. Cerebral computed tomography revealed an increased ventricular size. Based on the clinical diagnosis of abdominal pseudocyst, the peritoneal shunt catheter was secured and divided into two parts by cutting it on the chest; then, the proximal side of the peritoneal shunt catheter was externalized for extraventricular drainage. The cyst was percutaneously aspirated with ultrasound guidance, and the distal side of the peritoneal shunt catheter was removed. The distal side of the peritoneal shunt catheter was reinserted in another position into his abdomen after 3-week extraventricular drainage management. CONCLUSION: Emergency physicians should know about this potential complication as an important differential diagnosis resulting from acute abdominal complaints in patients with ventriculoperitoneal shunts.

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  • High-Mobility Group Box-1-Induced Angiogenesis After Indirect Bypass Surgery in a Chronic Cerebral Hypoperfusion Model. 国際誌

    Shingo Nishihiro, Tomohito Hishikawa, Masafumi Hiramatsu, Naoya Kidani, Yu Takahashi, Satoshi Murai, Kenji Sugiu, Yusuke Higaki, Takao Yasuhara, Cesario V Borlongan, Isao Date

    Neuromolecular medicine   21 ( 4 )   391 - 400   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    High-mobility group box-1 (HMGB1) is a nuclear protein that promotes inflammation during the acute phase post-stroke, and enhances angiogenesis during the delayed phase. Here, we evaluated whether indirect revascularization surgery with HMGB1 accelerates brain angiogenesis in a chronic cerebral hypoperfusion model. Seven days after hypoperfusion induction, encephalo-myo-synangiosis (EMS) was performed with or without HMGB1 treatment into the temporal muscle. We detected significant increments in cortical vasculature (p < 0.01), vascular endothelial growth factor (VEGF) expression in the temporal muscle (p < 0.05), and ratio of radiation intensity on the operated side compared with the non-operated side after EMS in the HMGB1-treated group than in the control group (p < 0.01). Altogether, HMGB1 with EMS in a chronic hypoperfusion model promoted brain angiogenesis in a VEGF-dependent manner, resulting in cerebral blood flow improvement. This treatment may be an effective therapy for patients with moyamoya disease.

    DOI: 10.1007/s12017-019-08541-x

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  • Intracranial invasive fungal aneurysm due to Aspergillus sinusitis successfully treated by voriconazole plus internal carotid artery ligation therapy in an aged woman

    Mami Takemoto, Yasuyuki Ohta, Koh Tadokoro, Ryo Sasaki, Yoshiaki Takahashi, Kota Sato, Toru Yamashita, Nozomi Hishikawa, Jingwei Shang, Masafumi Hiramatsu, Kenji Sugiu, Tomohito Hishikawa, Isao Date, Koji Abe

    NEUROLOGY ASIA   24 ( 4 )   363 - 367   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ASEAN NEUROLOGICAL ASSOC  

    A fungal carotid aneurysm is an infrequently occurring infectious aneurysm that is usually treated by antifungal therapy plus surgical debridement of the infected vessel. We herein report an extremely rare case involving a patient with a medical history of bladder cancer treated by Bacillus Calmette-Guerin (BCG) who developed a fungal aneurysm of the internal carotid artery and thrombosis of the superior ophthalmic vein caused by maxillary Aspergillus sinusitis. The patient was successfully treated by antifungal, anticoagulant, and antiplatelet drugs combined with internal carotid artery ligation therapy. Internal carotid artery fungal aneurysm is associated with a high mortality rate, but the present case suggests that it can be successfully treated by antifungal therapy combined with a less invasive endovascular therapy.

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  • 蝶形骨縁および前頭蓋底髄膜腫の動脈解剖

    平松 匡文, 杉生 憲志, 菱川 朋人, 木谷 尚哉, 村井 智, 西 和彦, 山岡 陽子, 藤井 謙太郎, 黒住 和彦, 伊達 勲

    脳血管内治療   4 ( Suppl. )   S239 - S239   2019年11月

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    記述言語:日本語   出版者・発行元:(NPO)日本脳神経血管内治療学会  

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  • 脳腫瘍のPDD-これまでとこれから- 術中ナビゲーション手術における病変位置の特定不能例に対する5-アミノレブリン酸(5-ALA)の有用性

    黒住 和彦, 藤井 謙太郎, 亀田 雅博, 冨田 祐介, 島津 洋介, 伊達 勲

    日本レーザー医学会誌   40 ( Suppl. )   S68 - S68   2019年11月

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    記述言語:日本語   出版者・発行元:(NPO)日本レーザー医学会  

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  • Animal Models for Parkinson's Disease Research: Trends in the 2000s. 国際誌

    Kyohei Kin, Takao Yasuhara, Masahiro Kameda, Isao Date

    International journal of molecular sciences   20 ( 21 )   2019年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Parkinson's disease (PD) is a chronic and progressive movement disorder and the second most common neurodegenerative disease. Although many studies have been conducted, there is an unmet clinical need to develop new treatments because, currently, only symptomatic therapies are available. To achieve this goal, clarification of the pathology is required. Attempts have been made to emulate human PD and various animal models have been developed over the decades. Neurotoxin models have been commonly used for PD research. Recently, advances in transgenic technology have enabled the development of genetic models that help to identify new approaches in PD research. However, PD animal model trends have not been investigated. Revealing the trends for PD research will be valuable for increasing our understanding of the positive and negative aspects of each model. In this article, we clarified the trends for animal models that were used to research PD in the 2000s, and we discussed each model based on these trends.

    DOI: 10.3390/ijms20215402

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  • Prosthesis Used in Microvascular Decompressions: A Multicenter Survey in Japan Focusing on Adverse Events. 査読 国際誌

    Mitsuhiro Hasegawa, Toru Hatayama, Akinori Kondo, Shinji Nagahiro, Takamitsu Fujimaki, Kenichi Amagasaki, Kazunori Arita, Isao Date, Yukihiko Fujii, Takeo Goto, Ryosuke Hanaya, Yoshinori Higuchi, Kazuhiro Hongo, Toru Inoue, Hidetoshi Kasuya, Takamasa Kayama, Masatou Kawashima, Eiji Kohmura, Taketoshi Maehara, Toshio Matsushima, Yoshihumi Mizobuchi, Akio Morita, Shigeru Nishizawa, Shusaku Noro, Shinjiro Saito, Hirofumi Shimano, Reizo Shirane, Hideo Takeshima, Yuichiro Tanaka, Hidenori Tanabe, Hiroki Toda, Iwao Yamakami, Yuya Nishiyama, Shigeo Ohba, Yuichi Hirose, Takeya Suzuki

    World neurosurgery   130   e251-e258 - e258   2019年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: To investigate the characteristics of materials used as prostheses for microvascular decompression surgery (MVDs) in Japan and their possible adverse events (AEs) to determine preferable materials for MVDs. METHODS: A questionnaire was sent to all members of the Japanese Society for MVDs, and answers were obtained from 59 institutions. RESULTS: Among a total of 2789 MVDs, 1088 operations for trigeminal neuralgia, 1670 for hemifacial spasm, and 31 others, including 117 reoperations, were performed between April 2011 and March 2014. Nonabsorbable material was used in 96.5% of MVDs, including polytetrafluoroethylene (PTFE) (80.5%), polyurethane (11.9%), expanded PTFE (2.1%), and silk thread (1.47%). The use of absorbable materials, including fibrin glue (87.5%), cellulose (13.5%), gelatin (4,77%), and collagen (1.76%), was reported. The major combinations were PTFE with fibrin glue (58.7%) followed by PTFE alone (7.60%). Eighty-eight AEs in 85 (3.2%) cases were reported among 2672 first operations. AEs included 51 central nervous system dysfunctions, 15 wound infections/dehiscence, and 10 others, which were presumed to be related to the intraoperative procedure. Among relatively high-, moderate-, and low-volume centers, there were no significant differences in the frequency of AEs (P = 0.077). Tissue-prosthesis adhesion and/or granuloma formation were reported in 13 cases of 117 reoperations. The incidence of adhesion-related recurrence was 11.1% of all reoperations. CONCLUSIONS: The number of AEs was quite low in this survey, and intradural use of any prosthesis reported in this paper might be justified; however, further development of easily handled and less-adhesive prosthesis materials is awaited.

    DOI: 10.1016/j.wneu.2019.06.053

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  • 多発性の大脳・脳幹病変を認め、診断及び治療に苦慮した抗MOG抗体関連症候群の1例

    松本 菜見子, 佐藤 恒太, 河原 由子, 武本 麻美, 菱川 望, 表 芳夫, 商 敬偉, 太田 康之, 山下 徹, 藤井 謙太郎, 黒住 和彦, 伊達 勲, 阿部 康二

    神経治療学   36 ( 6 )   S251 - S251   2019年10月

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    記述言語:日本語   出版者・発行元:(一社)日本神経治療学会  

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  • Clinicopathological and Genetic Features of Supratentorial Cortical Ependymomas. 国際誌

    Yuji Matsumoto, Tomotsugu Ichikawa, Kazuhiko Kurozumi, Yoshihiro Otani, Isao Date

    World neurosurgery   129   e417-e428   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: Supratentorial cortical ependymomas (CEs) are rare. These lesions, selectively occurring in the superficial cortex, have not been fully characterized. We analyzed the clinicopathological and genetic features of CEs. METHODS: Eight patients with CEs from our institution and 84 other reported CE cases were included in the present study. We retrospectively reviewed their clinical characteristics, imaging findings, treatment methods, pathological features, molecular status, and clinical outcomes. RESULTS: The median age at diagnosis of our 8 patients was 7.5 years. The mean tumor diameter was 70 mm. All the tumors had a cystic appearance, and calcification was observed in 6. Gross total resection was achieved in 6 patients and subtotal resection in 2 patients. Of the 8 tumors, 7 were World Health Organization grade III and 1 was World Health Organization grade II. Six tumors were immunopositive for L1 cell adhesion molecule (L1CAM). We investigated the presence of C11orf95-RELA fusion in 5 patients, all of whom exhibited it. Postoperative radiotherapy was performed for all patients with grade III tumors, except for children aged <3 years. Although 4 patients developed recurrence, all were alive throughout the follow-up period. Compared with previously reported CEs, our patients were younger and had larger tumors; however, the clinical outcomes did not differ significantly. CONCLUSIONS: Although most CEs in our group were immunopositive for L1CAM and showed C11orf95-RELA fusion, which have been associated with a poor prognosis in supratentorial ependymomas, all our patients had good outcomes. Gross total resection and adjuvant radiotherapy contributed to the relatively favorable prognosis of CEs compared with other supratentorial ependymomas.

    DOI: 10.1016/j.wneu.2019.05.166

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  • Lithium counteracts depressive behavior and augments the treatment effect of selective serotonin reuptake inhibitor in treatment-resistant depressed rats. 国際誌

    Kyohei Kin, Takao Yasuhara, Satoshi Kawauchi, Masahiro Kameda, Kakeru Hosomoto, Yousuke Tomita, Michiari Umakoshi, Ken Kuwahara, Ittetsu Kin, Naoya Kidani, Jun Morimoto, Tatsuya Sasaki, Isao Date

    Brain research   1717   52 - 59   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Wistar Kyoto (WKY) rats are a useful animal model of treatment-resistant depression. Lithium is effective for treating recurrent mood disorders or treatment-resistant depression, and lithium augmentation treatment is also useful for treatment-resistant depression. However, the treatment effect of lithium on the depressive behavior of WKY rats remains poorly understood, and whether lithium augments the treatment effect of antidepressants in WKY rats is also unknown. In this study, we evaluated the treatment effect of lithium in WKY rats. We also sought to determine if lithium treatment augments the treatment effect of fluoxetine. Lithium was administered for 15 consecutive days and fluoxetine was administered 23.5, 5, and 1 h before the forced swim test (FST) day 2, based on previous studies. Lithium treatment counteracted depressive behavior in the FST and increased hippocampal neurogenesis. Additionally, co-administration of lithium and fluoxetine augmented the treatment effect observed in the FST and in hippocampal neurogenesis in WKY rats, although fluoxetine monotherapy showed no treatment effect. Lithium prevented an increase in body weight, similar to its effect in human patients. These results are consistent with those of lithium augmentation treatment for human patients with treatment-resistant depression. They suggest that WKY rats are a promising animal model for treatment-resistant depression. However, lithium treatment has various side effects. A new treatment with the same anti-depressive effect as fluoxetine + lithium treatment and fewer side effects compared with lithium would be desirable for patients with treatment-resistant depression.

    DOI: 10.1016/j.brainres.2019.04.001

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  • A comparison of the prevalence and risk factors of complications in intracranial tumor embolization between the Japanese Registry of NeuroEndovascular Therapy 2 (JR-NET2) and JR-NET3. 国際誌

    Tomohito Hishikawa, Kenji Sugiu, Satoshi Murai, Yu Takahashi, Naoya Kidani, Shingo Nishihiro, Masafumi Hiramatsu, Isao Date, Tetsu Satow, Koji Iihara, Nobuyuki Sakai

    Acta neurochirurgica   161 ( 8 )   1675 - 1682   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The Japanese Registry of NeuroEndovascular Therapy 2 (JR-NET2) and 3 (JR-NET3) were nationwide surveys that evaluated clinical outcomes after neuroendovascular therapy in Japan. The aim of this study was to compare the prevalence and risk factors of complications of intracranial tumor embolization between JR-NET2 and JR-NET3. METHODS: A total of 1018 and 1545 consecutive patients with intracranial tumors treated with embolization were enrolled in JR-NET2 and JR-NET3, respectively. The prevalence of complications in intracranial tumor embolization and related risk factors were compared between JR-NET2 and JR-NET3. RESULTS: The prevalence of complications in JR-NET3 (3.69%) was significantly higher than that in JR-NET2 (1.48%) (p = 0.002). The multivariate analysis in JR-NET2 showed that embolization for tumors other than meningioma was the only significant risk factor for complication (odds ratio [OR], 3.88; 95% confidence interval [CI], 1.13-12.10; p = 0.032), and that in JR-NET3 revealed that embolization for feeders other than external carotid artery (ECA) (OR, 3.56; 95% CI, 2.03-6.25; p < 0.001) and use of liquid materials (OR, 2.65; 95% CI, 1.50-4.68; p < 0.001) were significant risks for complications. The frequency of embolization for feeders other than ECA in JR-NET3 (15.3%) was significantly higher than that in JR-NET2 (9.2%) (p < 0.001). Also, there was a significant difference in the frequency of use of liquid materials between JR-NET2 (21.2%) and JR-NET3 (41.2%) (p < 0.001). CONCLUSIONS: Embolization for feeders other than ECA and use of liquid materials could increase the complication rate in intracranial tumor embolization.

    DOI: 10.1007/s00701-019-03970-w

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  • Oncolytic Herpes Virus Armed with Vasculostatin in Combination with Bevacizumab Abrogates Glioma Invasion via the CCN1 and AKT Signaling Pathways. 国際誌

    Yusuke Tomita, Kazuhiko Kurozumi, Ji Young Yoo, Kentaro Fujii, Tomotsugu Ichikawa, Yuji Matsumoto, Atsuhito Uneda, Yasuhiko Hattori, Toshihiko Shimizu, Yoshihiro Otani, Tetsuo Oka, Balveen Kaur, Isao Date

    Molecular cancer therapeutics   18 ( 8 )   1418 - 1429   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Anti-VEGF treatments such as bevacizumab have demonstrated convincing therapeutic advantage in patients with glioblastoma. However, bevacizumab has also been reported to induce invasiveness of glioma. In this study, we examined the effects of rapid antiangiogenesis mediated by oncolytic virus (RAMBO), an oncolytic herpes simplex virus-1 expressing vasculostatin, on bevacizumab-induced glioma invasion. The effect of the combination of RAMBO and bevacizumab in vitro was assessed by cytotoxicity, migration, and invasion assays. For in vivo experiments, glioma cells were stereotactically inoculated into the brain of mice. RAMBO was intratumorally injected 7 days after tumor inoculation, and bevacizumab was administered intraperitoneally twice a week. RAMBO significantly decreased both the migration and invasion of glioma cells treated with bevacizumab. In mice treated with bevacizumab and RAMBO combination, the survival time was significantly longer and the depth of tumor invasion was significantly smaller than those treated with bevacizumab monotherapy. Interestingly, RAMBO decreased the expression of cysteine-rich protein 61 and phosphorylation of AKT, which were increased by bevacizumab. These results suggest that RAMBO suppresses bevacizumab-induced glioma invasion, which could be a promising approach to glioma therapy.

    DOI: 10.1158/1535-7163.MCT-18-0799

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  • Dynamic Reorganization of Microtubule and Glioma Invasion.

    Yoshihiro Otani, Tomotsugu Ichikawa, Kazuhiko Kurozumi, Isao Date

    Acta medica Okayama   73 ( 4 )   285 - 297   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Gliomas are characterized as highly diffuse infiltrating tumors, and currently available treatments such as surgery, radiation and chemotherapy are unfeasible or show limited efficacy against these tumors. Recent genetic and epigenetic analyses of glioma have revealed increasing evidence of the role of driver genetic alterations in glioma development and led to the identification of prognostic factors. Despite these findings, the survival rates of glioma patients remain low, and alternative treatments and novel targets are needed. Recent studies identified neural stem cells as the possible origin of gliomas, and some evidence has revealed shared functions and mechanisms between glioma cells and neurons, also supporting their similarity. The cytoskeleton plays important roles in the migration of normal cells as well as cancer cells. Recent reports have described a role for microtubules, a component of the cytoskeleton, in glioma invasion. Notably, several factors that regulate microtubule functions, such as microtubule-associated proteins, plus-end tracking proteins, or motor proteins, are upregulated in glioma tissues compared with normal tissue, and upregulation of these factors is associated with high invasiveness of glioma cells. In this review, we describe the mechanism of microtubules in glioma invasion and discuss the possibility of microtubule-targeted therapy to inhibit glioma invasion.

    DOI: 10.18926/AMO/56930

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  • 脳動脈瘤コイリング・クリッピング治療後のネック・ドームの新しい画像評価─Silent MRAとFSE MRCの3D 融合画像 の応用─ 査読

    佐藤 透、菱川朋人、杉生憲志、平松匡文、伊達 勲

    脳神経外科速報   29 ( 7 )   762 - 772   2019年7月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • High-grade glioneuronal tumor with an ARHGEF2-NTRK1 fusion gene. 査読

    Kazuhiko Kurozumi, Yoshiko Nakano, Joji Ishida, Takehiro Tanaka, Masatomo Doi, Junko Hirato, Akihiko Yoshida, Kana Washio, Akira Shimada, Takashi Kohno, Koichi Ichimura, Hiroyuki Yanai, Isao Date

    Brain tumor pathology   36 ( 3 )   121 - 128   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Here, we report a highly unusual case of high-grade glioneuronal tumor with a neurotrophic tropomyosin receptor kinase (NTRK) fusion gene. A 13-year-old girl presented with headache and vomiting and MRI detected two cystic lesions bilaterally in the frontal areas with surrounding edema. The left larger tumor was removed by left frontal craniotomy. The tumor was diagnosed as a high-grade glioneuronal tumor, unclassified. Methylation profiling classified it as a diffuse leptomeningeal glioneuronal tumor (DLGNT) with low confidence. This tumor showed genotypes frequently found in DLGNT such as 1p/19q codeletion without IDH mutation and, however, did not have the typical DLGNT clinical and histological features. RNA sequencing identified an ARHGEF2 (encoding Rho/Rac guanine nucleotide exchange factor 2)-NTRK1 fusion gene. The presence of recurrent NTRK fusion in glioneuronal tumors has an important implication in the clinical decision making and opens up a possibility of novel targeted therapy.

    DOI: 10.1007/s10014-019-00345-y

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  • [Health Economics Studies in the Neurosurgical Field:An Introduction to Cost-Effectiveness Analysis and a Literature Review].

    Masahiro Kameda, Isao Date

    No shinkei geka. Neurological surgery   47 ( 7 )   707 - 717   2019年7月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.11477/mf.1436204014

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  • Results of 1940 embolizations for dural arteriovenous fistulas: Japanese Registry of Neuroendovascular Therapy (JR-NET3). 国際誌

    Masafumi Hiramatsu, Kenji Sugiu, Tomohito Hishikawa, Shingo Nishihiro, Naoya Kidani, Yu Takahashi, Satoshi Murai, Isao Date, Naoya Kuwayama, Tetsu Satow, Koji Iihara, Nobuyuki Sakai

    Journal of neurosurgery   1 - 8   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: Embolization is the most common treatment for dural arteriovenous fistulas (dAVFs). A retrospective, multicenter observational study was conducted in Japan to clarify the nature, frequency, and risk factors for complications of dAVF embolization. METHODS: Patient data were derived from the Japanese Registry of Neuroendovascular Therapy 3 (JR-NET3). A total of 40,169 procedures were registered in JR-NET3, including 2121 procedures (5.28%) in which dAVFs were treated with embolization. After data extraction, the authors analyzed complication details and risk factors in 1940 procedures performed in 1458 patients with cranial dAVFs treated with successful or attempted embolization. RESULTS: Transarterial embolization (TAE) alone was performed in 858 cases (44%), and transvenous embolization (TVE) alone was performed in 910 cases (47%). Both TAE and TVE were performed in one session in 172 cases (9%). Complications occurred in 149 cases (7.7%). Thirty-day morbidity and mortality occurred in 55 cases (2.8%) and 16 cases (0.8%), respectively. Non-sinus-type locations, radical embolization as the strategy, procedure done at a hospital that performed dAVF embolization in fewer than 10 cases during the study period, and emergency procedures were independent risk factors for overall complications. CONCLUSIONS: Complication rates of dAVF embolization in Japan were acceptable. For better results, the risk factors identified in this study should be considered in treatment decisions.

    DOI: 10.3171/2019.4.JNS183458

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  • 難治性疼痛に対する脊髄刺激療法─難治性疼痛に対する脊髄刺激療法─ 招待

    上利 崇、伊達 勲

    脳神経外科ジャーナル   28 ( 6 )   334 - 341   2019年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Questionnaire Survey Regarding Prevention of Surgical Site Infection after Neurosurgery in Japan: Focus on Perioperative Management and Administration of Surgical Antibiotic Prophylaxis.

    Shingo Matsuda, Fusao Ikawa, Hideo Ohba, Michitsura Yoshiyama, Toshikazu Hidaka, Kaoru Kurisu, Susumu Miyamoto, Isao Date, Hiroyuki Nakase

    Neurologia medico-chirurgica   59 ( 6 )   197 - 203   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Various guidelines regarding surgical site infection (SSI) have recently been established. However, perioperative management of the wound and use of antibiotics have never been standardized completely in departments of neurosurgery in Japan. This survey investigated current perioperative management and administration of surgical antibiotic prophylaxis (SAP) and compared with guidelines intended to reduce SSI associated with neurosurgery in Japan. Questionnaires were distributed to members of the conference on Neurosurgical Techniques and Tools and the Japan Society of Aesthetic Neurosurgery via internet. The questionnaires asked about methods of perioperative management. A total of 255 members returned answers to the questionnaires. The questionnaires revealed that partial or no removal of the hair and hair shampooing at the day before surgery were performed in 96.1% and 88.1% of each institute following the World Health Organization (WHO) guidelines. Use of SAP at just before, during, and after surgery were 65.0%, 86.2%, and 63.0%, respectively. The postoperative period of use of intravenous SAP prolonged beyond 24 h in 80.0% against the recommendation of WHO. Perioperative management of wounds and use of SAP varies in institutes in Japan and some procedures were far different from the WHO guidelines. Japanese neurosurgeons should notice the prolonged SAP and comply with the WHO guidelines.

    DOI: 10.2176/nmc.oa.2018-0328

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  • 内頚動脈後交通動脈分岐部瘤に対する後交通動脈を温存した塞栓術後の再発リスク 査読

    平松匡文、杉生憲志、菱川朋人、西廣真吾、木谷尚哉、高橋 悠、村井 智、伊達 勲

    脳卒中の外科   47 ( 3 )   167 - 173   2019年5月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 微小環境 神経膠腫(2) Bevacizumab治療におけるグリオーマ浸潤関連因子の検索

    黒住 和彦, 石田 穣治, 大谷 理浩, 清水 俊彦, 冨田 祐介, 松本 悠司, 畝田 篤仁, 服部 靖彦, 藤井 謙太郎, 伊達 勲

    Brain Tumor Pathology   36 ( Suppl. )   071 - 071   2019年5月

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    記述言語:日本語   出版者・発行元:日本脳腫瘍病理学会  

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  • 当院での膠芽腫長期生存症例の分子生物学的検討

    藤井 謙太郎, 黒住 一彦, 冨田 祐介, 服部 靖彦, 松本 悠司, 畝田 篤仁, 坪井 伸成, 伊達 勲

    Brain Tumor Pathology   36 ( Suppl. )   103 - 103   2019年5月

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    記述言語:日本語   出版者・発行元:日本脳腫瘍病理学会  

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  • Annexin A2の発現変化により規定されるグリオーマ表現型シフトの分子機序解明

    松本 悠司, 市川 智継, 黒住 和彦, 大谷 理浩, 藤村 篤史, 藤井 謙太郎, 冨田 祐介, 服部 靖彦, 畝田 篤人, 伊達 勲

    Brain Tumor Pathology   36 ( Suppl. )   083 - 083   2019年5月

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    記述言語:日本語   出版者・発行元:日本脳腫瘍病理学会  

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  • Matricellular protein CCN1による悪性神経膠腫進展の分子メカニズム

    畝田 篤仁, 黒住 和彦, 藤村 篤史, 藤井 謙太郎, 冨田 祐介, 服部 靖彦, 松本 悠司, 坪井 伸成, 神谷 厚範, 伊達 勲

    Brain Tumor Pathology   36 ( Suppl. )   083 - 083   2019年5月

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    記述言語:日本語   出版者・発行元:日本脳腫瘍病理学会  

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  • Gliomaに対する第2世代REIC/Dkk-3遺伝子発現アデノウイルスとbevacizumabの併用効果

    服部 靖彦, 黒住 和彦, 畝田 篤仁, 松本 悠司, 坪井 伸成, 冨田 祐介, 藤井 謙太郎, 公文 裕巳, 伊達 勲

    Brain Tumor Pathology   36 ( Suppl. )   095 - 095   2019年5月

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    記述言語:日本語   出版者・発行元:日本脳腫瘍病理学会  

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  • Vstat120を発現する腫瘍溶解ヘルペスウイルスはベバシズマブ誘発性グリオーマ浸潤を抑制する

    冨田 祐介, 黒住 和彦, 松本 悠司, 畝田 篤仁, 服部 靖彦, 清水 俊彦, 大谷 理浩, 藤井 謙太郎, Balveen Kaur, 伊達 勲

    Brain Tumor Pathology   36 ( Suppl. )   097 - 097   2019年5月

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    記述言語:日本語   出版者・発行元:日本脳腫瘍病理学会  

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  • 頭蓋内に発生した若年性黄色肉芽腫(Juvenile xanthogranuloma)の1例

    坪井 伸成, 亀田 雅博, 黒住 和彦, 西 和彦, 井本 良二, 鷲尾 佳奈, 柳井 広之, 伊達 勲

    Brain Tumor Pathology   36 ( Suppl. )   126 - 126   2019年5月

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    記述言語:日本語   出版者・発行元:日本脳腫瘍病理学会  

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  • Visualization of Aneurysmal Neck and Dome after Coiling with 3D Multifusion Imaging of Silent MRA and FSE-MR Cisternography. 国際誌

    T Satoh, T Hishikawa, M Hiramatsu, K Sugiu, I Date

    AJNR. American journal of neuroradiology   40 ( 5 )   802 - 807   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND AND PURPOSE: Our aim was to visualize the precise configuration of the aneurysmal neck and dome with/without remnants combined with a coiled dome after coiling treatment for cerebral aneurysms. We developed 3D multifusion imaging of silent MRA and FSE-MR cisternography. MATERIALS AND METHODS: We examined 12 patients with 3D multifusion imaging by composing 3D images reconstructed from TOF-MRA, silent MRA, and FSE-MR cisternography. The influence of magnetic susceptibility artifacts caused by metal materials affecting the configuration of the aneurysmal complex with coiling was assessed in a single 3D image. RESULTS: In all cases, TOF-MRA failed to depict the aneurysmal neck complex precisely due to metal artifacts, whereas silent MRA delineated the neck and parent arteries at the coiled regions without serious metal artifacts. FSE-MR cisternography depicted the shape of the coiled aneurysmal dome and parent artery complex together with the brain parenchyma. With the 3D multifusion images of silent MRA and FSE-MR cisternography, the morphologic status of the coiled neck and parent arteries was clearly visualized with the shape of the dome in a single 3D image. CONCLUSIONS: Silent MRA is a non-contrast-enhanced form of MRA. It depicts the coiled neck complex without serious metal artifacts. FSE-MR cisternography can delineate the shape of the coiled dome. In this small feasibility study, 3D multifusion imaging of silent MRA and FSE-MR cisternography allowed good visualization of key features of coiled aneurysms. This technique may be useful in the follow-up of coiled aneurysms.

    DOI: 10.3174/ajnr.A6026

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  • δ-Catenin Promotes Bevacizumab-Induced Glioma Invasion. 国際誌

    Toshihiko Shimizu, Joji Ishida, Kazuhiko Kurozumi, Tomotsugu Ichikawa, Yoshihiro Otani, Tetsuo Oka, Yusuke Tomita, Yasuhiko Hattori, Atsuhito Uneda, Yuji Matsumoto, Isao Date

    Molecular cancer therapeutics   18 ( 4 )   812 - 822   2019年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The combination of bevacizumab with temozolomide and radiotherapy was shown to prolong progression-free survival in newly diagnosed patients with glioblastoma, and this emphasizes the potential of bevacizumab as a glioma treatment. However, although bevacizumab effectively inhibits angiogenesis, it has also been reported to induce invasive proliferation. This study examined gene expression in glioma cells to investigate the mechanisms of bevacizumab-induced invasion. We made a human glioma U87ΔEGFR cell xenograft model by stereotactically injecting these cells into the brain of animals. We administered bevacizumab intraperitoneally three times per week. At 18 days after tumor implantation, the brains were removed for histopathology and mRNA was extracted. In vivo, bevacizumab treatment increased glioma cell invasion. qRT-PCR array analysis revealed upregulation of δ-catenin (CTNND2) and several other factors. In vitro, bevacizumab treatment upregulated δ-catenin expression. A low concentration of bevacizumab was not cytotoxic, but tumor cell motility was increased in scratch wound assays and two-chamber assays. Overexpression of δ-catenin increased the tumor invasion in vitro and in vivo However, δ-catenin knockdown decreased glioma cell invasiveness. The depth of tumor invasion in the U87ΔEGFR cells expressing δ-catenin was significantly increased compared with empty vector-transfected cells. The increase in invasive capacity induced by bevacizumab therapy was associated with upregulation of δ-catenin expression in invasive tumor cells. This finding suggests that δ-catenin is related to tumor invasion and migration.

    DOI: 10.1158/1535-7163.MCT-18-0138

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  • Delayed postoperative hyponatremia after endoscopic transsphenoidal surgery for pituitary adenoma. 国際誌

    Yusuke Tomita, Kazuhiko Kurozumi, Kenichi Inagaki, Masahiro Kameda, Joji Ishida, Takao Yasuhara, Tomotsugu Ichikawa, Tomoko Sonoda, Fumio Otsuka, Isao Date

    Acta neurochirurgica   161 ( 4 )   707 - 715   2019年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Hyponatremia generally occurs after transsphenoidal surgery (TSS) in a delayed fashion. Most patients with delayed postoperative hyponatremia (DPH) are asymptomatic or only express non-specific symptoms; consequently, DPH is associated with prolonged hospitalization. No consensus has been reached on which patients are at greatest risk of developing DPH. We reviewed patients with DPH and evaluated predictive factors for DPH. METHODS: We retrospectively analyzed 107 consecutive patients who underwent endoscopic TSS for pituitary adenoma (January 2010-December 2016). Patients with DPH (hyponatremia group) and without DPH (normonatremia group) were compared according to their nadir sodium levels on postoperative days 3 to 10. We documented the patients' demographics, clinical features, and postoperative physiological characteristics. RESULTS: Twenty-five (23.4%) patients developed DPH after endoscopic TSS. The patients' mean age was 54 ± 17 years, and 63.6% of the patients were female. The overall prevalence of DPH was 23.4%. The non-parametric χ2 test and the Mann-Whitney U test revealed statistically significant differences in age, use of antihypertensive drugs, nonfunctioning pituitary adenoma, and higher yet normal preoperative thyroid-stimulating hormone level between the hyponatremia and normonatremia groups (P < 0.05). Logistic regression analysis revealed that only older age was a useful independent predictive factor for DPH (odds ratio, 1.05; 95% confidence interval, 1.01-1.08; P = 0.01). The serum sodium levels on postoperative day 2 were significantly lower in the hyponatremia than normonatremia group (P < 0.01) and were negatively correlated with age (r = - 0.25, P < 0.05). The cut-off age for predicting DPH was 55 years. The hospital stay was significantly longer in the hyponatremia than normonatremia group (P < 0.01). CONCLUSIONS: Age of more than 55 years was an independent predictive factor for DPH even after adjusting for potential confounders. Older age was negatively correlated with the serum sodium level on postoperative day 2. Preventing early decreases in the sodium level could reduce the risk of DPH. TRIAL REGISTRATION: 1707-027.

    DOI: 10.1007/s00701-019-03818-3

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  • 小児脳腫瘍の手術:手術手技と合併症回避 小児脳腫瘍に対する鏡視下手術

    黒住 和彦, 亀田 雅博, 藤井 謙太郎, 冨田 祐介, 安原 隆雄, 伊達 勲

    小児の脳神経   44 ( 2 )   137 - 137   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経外科学会  

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  • 中枢神経系疾患における神経新生とうつ病様症状─細胞移植、電気刺激、リハビリテーションによる治療─ 招待

    金 恭平、安原隆雄、伊達 勲

    Medical Science Digest (MSD)   45 ( 3 )   132 - 135   2019年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 未破裂脳動脈瘤の自然歴─最新の知識と臨床判断へのフィードバック─ 招待 査読

    菱川朋人、平松匡文、杉生憲志、伊達 勲

    脳神経外科ジャーナル   28 ( 3 )   120 - 126   2019年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 未破裂脳動脈瘤の自然歴─最新の知識と臨床判断へのフィードバック─ 招待

    菱川朋人、平松匡文、杉生憲志、伊達 勲

    脳神経外科ジャーナル   28 ( 3 )   120 - 126   2019年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Comparison between spinal dural arteriovenous fistula and spinal epidural arteriovenous fistula 査読 国際誌

    Hiramatsu M, Sugiu K, Yasuhara T, Hishikawa T, Nishihiro S, Kidani N, Takahashi Y, Murai S, Date I

    Journal of Neuroendovascular Therapy   13 ( 3 )   114 - 119   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • SF-36 scores predict postoperative delirium after surgery for cervical spondylotic myelopathy. 国際誌

    Kyohei Kin, Takao Yasuhara, Yousuke Tomita, Michiari Umakoshi, Jun Morimoto, Isao Date

    Journal of neurosurgery. Spine   1 - 6   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVECervical spondylotic myelopathy (CSM) is one of the most common causes of spinal cord dysfunction. Surgery for CSM is generally effective, but postoperative delirium is a potential complication. Although there have been some studies that investigated postoperative delirium after spine surgery, no useful tool for identifying high-risk patients has been established, and it is unknown if 36-Item Short Form Health Survey (SF-36) scores can predict postoperative delirium. The objective of this study was to evaluate the correlation between preoperative SF-36 scores and postoperative delirium after surgery for CSM.METHODSSixty-seven patients who underwent surgery for CSM at the authors' institution were enrolled in this study. Medical records of these patients were retrospectively reviewed. Patient background, preoperative laboratory data, preoperative SF-36 scores, the preoperative Japanese Orthopaedic Association (JOA) score for the evaluation of cervical myelopathy, and perioperative factors were selected as potential risk factors for postoperative delirium. These factors were evaluated using univariable and multivariable logistic regression analysis.RESULTSTen patients were diagnosed with postoperative delirium. Univariable analysis revealed that the physical functioning score (p = 0.01), general health perception score (p < 0.01), and vitality score (p < 0.01) of the SF-36 were significantly lower in patients with postoperative delirium than in those without. The total number of medications was significantly higher in the delirium group compared with the no-delirium group (p = 0.02). In contrast, there were no significant differences between the delirium group and the no-delirium group in cervical JOA scores (p = 0.20). Multivariable analysis revealed that a low general health perception score was an independent risk factor for postoperative delirium (p = 0.02; odds ratio 0.810, 95% confidence interval 0.684-0.960).CONCLUSIONSSome of the SF-36 scores were significantly lower in patients with postoperative delirium than in those without. In particular, the general health perception score was independently correlated with postoperative delirium. SF-36 scores could help identify patients at high risk for postoperative delirium and aid in the development of prevention strategies.

    DOI: 10.3171/2018.11.SPINE181031

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  • Treatment Outcome of Intracranial Tumor Embolization in Japan: Japanese Registry of NeuroEndovascular Therapy 3 (JR-NET3).

    Kenji Sugiu, Tomohito Hishikawa, Satoshi Murai, Yu Takahashi, Naoya Kidani, Shingo Nishihiro, Masafumi Hiramatsu, Isao Date, Tetsu Satow, Koji Iihara, Nobuyuki Sakai

    Neurologia medico-chirurgica   59 ( 2 )   41 - 47   2019年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Embolization for intracranial tumor is performed as a standard endovascular treatment. A retrospective, multicenter, observational study was conducted to clarify the nature, frequency, and risk factors of complications in intracranial tumor embolization. Patients were derived from the Japanese Registry of NeuroEndovascular Therapy (JR-NET3) using data taken from January 2010 through December 2014 in Japan. A total of 40,169 patients were enrolled in JR-NET3, of which, 1,545 patients (3.85%) with intracranial tumors underwent embolization. The primary end point was the proportion of patients with a modified Rankin scale (mRS) score of 0-2 (independency) at 30 days after embolization. The secondary end point was the occurrence of complications related to the procedures. The risk factors of the development of complications were analyzed. The proportion of patients with mRS scores ≤2 at 30 days after procedure was 89.5%. Complications occurred in 57 of the 1544 patients (3.7%). Multivariate analysis showed that target vessels other than external carotid artery (ECA) (OR, 3.56; 95% CI, 2.03-6.25; P <0.001) and use of liquid material (OR, 2.65; 95% CI, 1.50-4.68; P <0.001) were significantly associated with the development of complications. In JR-NET3, the primary end point was 89.5%, and the procedure-related complication rate was 3.7%. Embolization from other than ECA was significant risk factor of the complications. In addition, increasing usage of liquid embolic material worsened the risk of complications.

    DOI: 10.2176/nmc.st.2018-0220

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  • 脳表動脈が出血源の急性硬膜下血腫手術における、顕微鏡下直接縫合による損傷脳表動脈修復の有効性の検討 査読

    畝田 篤仁, 平下 浩司, 藪野 諭, 柚木 正敏, 吉野 公博, 伊達 勲

    日本脳神経外傷学会プログラム・抄録集   42回   72 - 72   2019年2月

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    記述言語:日本語   出版者・発行元:(一社)日本脳神経外傷学会  

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  • Endovascular treatment for unruptured aneurysm associated with persistent primitive trigeminal artery: a case report and literature review. 国際誌

    Satoshi Murai, Kenji Sugiu, Tomohito Hishikawa, Masafumi Hiramatsu, Shingo Nishihiro, Naoya Kidani, Yu Takahashi, Isao Date

    Acta neurochirurgica   161 ( 2 )   407 - 411   2019年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The persistent primitive trigeminal artery (PPTA) is the most common carotid-basilar anastomosis, and the incidence of cerebral aneurysms associated with the PPTA is approximately 4%. Since PPTA aneurysms often have a wide neck and other vascular anomalies, endovascular treatment using an adjunctive technique is the current first-line therapy. Here, we report a case of PPTA aneurysm treated by coil embolization with a stent-assisted technique. A detailed evaluation of the size and course of all vessels and collateral flow, including the Allcock test and balloon test occlusion, is necessary when deciding on the treatment strategy.

    DOI: 10.1007/s00701-018-3767-6

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  • Rupture risk of small unruptured cerebral aneurysms. 査読 国際誌

    Fusao Ikawa, Akio Morita, Shinjiro Tominari, Takeo Nakayama, Yoshiaki Shiokawa, Isao Date, Kazuhiko Nozaki, Susumu Miyamoto, Takamasa Kayama, Hajime Arai

    Journal of neurosurgery   1 - 10   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVEThe annual rupture rate of small (3-4 mm) unruptured cerebral aneurysms (UCAs) is 0.36% per year, however, the proportion of small ruptured aneurysms < 5 mm is 35%. This discrepancy is explained by the hypothesis that most acute subarachnoid hemorrhage (SAH) is from recently formed, unscreened aneurysms, but this hypothesis is without definitive proof. The authors aimed to clarify the actual number of screened, ruptured small aneurysms and risk factors for rupture.METHODSThe Unruptured Cerebral Aneurysm Study Japan, a project of the Japan Neurosurgical Society, was designed to clarify the natural course of UCAs. From January 2001 through March 2004, 6697 UCAs among 5720 patients were prospectively registered. At registration, 2839 patients (49.6%) had 3132 (46.8%) small UCAs of 3-4 mm. The registered, treated, and rupture numbers of these small aneurysms and the annual rupture rate were investigated. The rate was assessed per aneurysm. The characteristics of patients and aneurysms were compared to those of larger unruptured aneurysms (≥ 5 mm). Cumulative rates of SAH were estimated per aneurysm. Risk factors underwent univariate and multivariate analysis.RESULTSTreatment and rupture numbers of small UCAs were 1132 (37.1% of all treated aneurysms) and 23 (20.7% of all ruptured aneurysms), respectively. The registered, treated, rupture number, and annual rupture rates were 1658 (24.8%), 495 (16.2%), 11 (9.9%), and 0.30%, respectively, among 3-mm aneurysms, and 1474 (22.0%), 637 (20.9%), 12 (10.8%), and 0.45%, respectively, among 4-mm aneurysms. Multivariate risk-factor analysis revealed that a screening brain checkup (hazard ratio [HR] 4.1, 95% confidence interval [CI] 1.2-14.4), history of SAH (HR 10.8, 95% CI 2.3-51.1), uncontrolled hypertension (HR 5.2, 95% CI 1.8-15.3), and location on the anterior communicating artery (ACoA; HR 5.0, 95% CI 1.6-15.5) were independent predictors of rupture.CONCLUSIONSAlthough the annual rupture rate of small aneurysms was low, the actual number of ruptures was not low. Small aneurysms that ruptured during follow-up could be detected, screened, and managed based on each risk factor. Possible selection criteria for treating small UCAs include a history of SAH, uncontrolled hypertension, location on the ACoA, and young patients. Further large prospective and longitudinal trials are needed.Clinical trial registration no.: C000000418 (https://www.umin.ac.jp/ctr).

    DOI: 10.3171/2018.9.JNS181736

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  • Pituitary adenoma apoplexy associated with vardenafil intake. 国際誌

    Atsuhito Uneda, Koji Hirashita, Masatoshi Yunoki, Kimihiro Yoshino, Isao Date

    Acta neurochirurgica   161 ( 1 )   129 - 131   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Vardenafil is a potent phosphodiesterase-5 (PDE-5) inhibitor used in the treatment of erectile dysfunction. Several cases of stroke related to the use of PDE-5 inhibitors have been reported. Here, we describe the case of a 51-year-old man with headache and right ophthalmoplegia subsequent to vardenafil consumption. Computed tomography and magnetic resonance imaging showed a suprasellar mass with hemorrhage suggesting pituitary apoplexy. He underwent transsphenoidal resection of the pituitary mass. Histopathology confirmed the diagnosis of a necrotic pituitary adenoma with hemorrhage. This report suggests a possible association between pituitary apoplexy and vardenafil use. In patients with preexisting pituitary adenoma, vardenafil may enhance the risk of pituitary apoplexy. Although headache is the most commonly reported side effect of vardenafil, pituitary apoplexy should be considered in the differential diagnosis of a patient with headache and ophthalmoplegia subsequent to vardenafil intake.

    DOI: 10.1007/s00701-018-3763-x

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  • Cavernous malformation of the optic chiasm with continuous hemorrhage in a pregnant woman: A case report 査読 国際誌

    Tomita Y, Fujii K, Kurozumi K, Imoto R, Mitsui T, Mishima S, Inagaki K, Masuyama H, Date I

    Interdisciplinary Neurosurgery   18   2019年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.inat.2019.100489

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  • Endovascular treatment for craniofacial arteriovenous fistula/malformation 査読 国際誌

    Sugiu K, Hishikawa T, Hiramatsu M, Nishihiro S, Kidani N, Takahashi Y, Murai S, Date I

    Journal of Neuroendovascular Therapy   13 ( 5 )   206 - 215   2019年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors. 国際誌

    Kohei Fukuoka, Yonehiro Kanemura, Tomoko Shofuda, Shintaro Fukushima, Satoshi Yamashita, Daichi Narushima, Mamoru Kato, Mai Honda-Kitahara, Hitoshi Ichikawa, Takashi Kohno, Atsushi Sasaki, Junko Hirato, Takanori Hirose, Takashi Komori, Kaishi Satomi, Akihiko Yoshida, Kai Yamasaki, Yoshiko Nakano, Ai Takada, Taishi Nakamura, Hirokazu Takami, Yuko Matsushita, Tomonari Suzuki, Hideo Nakamura, Keishi Makino, Yukihiko Sonoda, Ryuta Saito, Teiji Tominaga, Yasuhiro Matsusaka, Keiichi Kobayashi, Motoo Nagane, Takuya Furuta, Mitsutoshi Nakada, Yoshitaka Narita, Yuichi Hirose, Shigeo Ohba, Akira Wada, Katsuyoshi Shimizu, Kazuhiko Kurozumi, Isao Date, Junya Fukai, Yousuke Miyairi, Naoki Kagawa, Atsufumi Kawamura, Makiko Yoshida, Namiko Nishida, Takafumi Wataya, Masayoshi Yamaoka, Naohiro Tsuyuguchi, Takehiro Uda, Mayu Takahashi, Yoshiteru Nakano, Takuya Akai, Shuichi Izumoto, Masahiro Nonaka, Kazuhisa Yoshifuji, Yoshinori Kodama, Masayuki Mano, Tatsuya Ozawa, Vijay Ramaswamy, Michael D Taylor, Toshikazu Ushijima, Soichiro Shibui, Mami Yamasaki, Hajime Arai, Hiroaki Sakamoto, Ryo Nishikawa, Koichi Ichimura

    Acta neuropathologica communications   6 ( 1 )   134 - 134   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Extensive molecular analyses of ependymal tumors have revealed that supratentorial and posterior fossa ependymomas have distinct molecular profiles and are likely to be different diseases. The presence of C11orf95-RELA fusion genes in a subset of supratentorial ependymomas (ST-EPN) indicated the existence of molecular subgroups. However, the pathogenesis of RELA fusion-negative ependymomas remains elusive. To investigate the molecular pathogenesis of these tumors and validate the molecular classification of ependymal tumors, we conducted thorough molecular analyses of 113 locally diagnosed ependymal tumors from 107 patients in the Japan Pediatric Molecular Neuro-Oncology Group. All tumors were histopathologically reviewed and 12 tumors were re-classified as non-ependymomas. A combination of RT-PCR, FISH, and RNA sequencing identified RELA fusion in 19 of 29 histologically verified ST-EPN cases, whereas another case was diagnosed as ependymoma RELA fusion-positive via the methylation classifier (68.9%). Among the 9 RELA fusion-negative ST-EPN cases, either the YAP1 fusion, BCOR tandem duplication, EP300-BCORL1 fusion, or FOXO1-STK24 fusion was detected in single cases. Methylation classification did not identify a consistent molecular class within this group. Genome-wide methylation profiling successfully sub-classified posterior fossa ependymoma (PF-EPN) into PF-EPN-A (PFA) and PF-EPN-B (PFB). A multivariate analysis using Cox regression confirmed that PFA was the sole molecular marker which was independently associated with patient survival. A clinically applicable pyrosequencing assay was developed to determine the PFB subgroup with 100% specificity using the methylation status of 3 genes, CRIP1, DRD4 and LBX2. Our results emphasized the significance of molecular classification in the diagnosis of ependymomas. RELA fusion-negative ST-EPN appear to be a heterogeneous group of tumors that do not fall into any of the existing molecular subgroups and are unlikely to form a single category.

    DOI: 10.1186/s40478-018-0630-1

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  • Neurolymphomatosis in the Cauda Equina Diagnosed by an Open Biopsy. 査読

    Ryo Sasaki, Yasuyuki Ohta, Yuto Yamada, Koh Tadokoro, Yoshiaki Takahashi, Kota Sato, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Takao Yasuhara, Isao Date, Shuntaro Ikegawa, Nobuharu Fujii, Koji Abe

    Internal medicine (Tokyo, Japan)   57 ( 23 )   3463 - 3465   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Neurolymphomatosis is a rare form of extranodal malignant lymphoma defined as the infiltration of malignant lymphocytes into the central or peripheral nerve. We herein report a case of neurolymphomatosis in the cauda equina diagnosed by an open surgical biopsy. He presented with muscle weakness, atrophy, numbness and hypoesthesia in the bilateral lower extremities with the accumulation of 18fluoro-2-deoxyglucose (FDG) in the bilateral cauda equina. Cerebrospinal fluid cytology (three times) and flow cytometry (two times) and biopsies of the left sural nerve, bone marrow, paranasal sinus and left testis were all negative for malignancy, so finally we performed a surgical open biopsy of the cauda equina by laminectomy and diagnosed him with diffuse large B-cell lymphoma in the cauda equina. He was successfully treated with the disappearance of the FDG accumulation for a long time. The present case suggested that an early open biopsy of the cauda equina may be considered for cases of suspected neurolymphomatosis in the cauda equina for a good outcome.

    DOI: 10.2169/internalmedicine.1049-18

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  • Characteristics and prognostic factors of Parkinson's disease patients with abnormal postures subjected to subthalamic nucleus deep brain stimulation. 国際誌

    Mihoko Okazaki, Tatsuya Sasaki, Takao Yasuhara, Masahiro Kameda, Takashi Agari, Ittetsu Kin, Ken Kuwahara, Jun Morimoto, Kyohei Kin, Michiari Umakoshi, Yousuke Tomita, Cesario V Borlongan, Isao Date

    Parkinsonism & related disorders   57   44 - 49   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: In Parkinson's disease (PD), abnormal postures are often accompanied, which interfere with rehabilitation and subsequent functional recovery. This study investigated the relationship between clinical characteristics and improvement in abnormal postures of PD patients who received subthalamic nucleus deep brain stimulation (STN-DBS). METHODS: Seventy-four PD patients were included in this study. Clinical data were analyzed using the patients' functional status at pre- and post-STN-DBS, including anteflexion vs. non-anteflexion, scoliosis vs. non-scoliosis, improved anteflexion vs. non-improved anteflexion, and improved scoliosis vs. non-improved scoliosis. RESULTS: In patients with anteflexion, UPDRS III motor score at off medication was worse than that of patients with non-anteflexion. Patients with scoliosis presented with more comorbid spinal deformity and longer disease duration than those without scoliosis. Cobb angle of patients with asymmetrical psoas major and erector spinal muscles was more than that of patients without the asymmetry. Patients with improved anteflexion after STN-DBS had thicker abdominal oblique muscle and transverse abdominal muscle than those of patients without improved anteflexion. Patients with improved scoliosis were significantly younger at PD onset than those without improvement. CONCLUSIONS: There were only a few prognostic factors recognized in patients with improved postures. The thick abdominal muscle for anteflexion and younger PD onset for scoliosis were significant factors for improvement by STN-DBS. Rehabilitation designed to maintain muscle for correct postures may contribute to the amelioration of abnormal postures by STN-DBS, although multicenter trials are needed.

    DOI: 10.1016/j.parkreldis.2018.07.014

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  • Cervical compressive myelopathy caused by malfunction of a programmable cerebrospinal fluid shunt valve

    Kota Sato, Toru Yamashita, Keichiro Tsunoda, Mami Takemoto, Nozomi Hishikawa, Jinwei Shang, Yasuyuki Ohta, Ken Kuwahara, Takao Yasuhara, Isao Date, Koji Abe

    INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT   14   183 - 185   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    The primary treatment for hydrocephalus is ventricular shunt placement, and a programmable valve is widely used for ventriculoperitoneal (VP) shunt surgery to reduce over/under drainage of cerebrospinal fluid (CSF). Here, we report a rare case of a patient who developed successive VP shunt malfunction causing spastic muscle weakness in extremities associated cervical epidural venous distension and compressive myelopathy due to over-drainage of CSF through a defective VP shunt valve a decade after the initial shunt was placed. One should be aware and cognizant of this complication and carefully follow the symptoms and potentially utilize brain MRI with and without contrast to look at over drainage stigmata to avoid the development of neurological complications.

    DOI: 10.1016/j.inat.2018.08.009

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  • 神経保護と再生に対するリハビリテーションの効果 招待

    安原隆雄、伊達 勲

    総合リハビリテーション   46 ( 11 )   1029 - 1032   2018年11月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Anti-High Mobility Group Box 1 Antibody Therapy May Prevent Cognitive Dysfunction After Traumatic Brain Injury. 査読 国際誌

    Okuma Y, Wake H, Teshigawara K, Takahashi Y, Hishikawa T, Yasuhara T, Mori S, Takahashi HK, Date I, Nishibori M

    World neurosurgery   122   e864 - e871   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.wneu.2018.10.164

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  • Ex vivo release of pipeline embolization device polytetrafluoroethylene sleeves: a technical note 査読 国際誌

    Takahashi Y, Sugiu K, Haruma J, Murai S, Kidani N, Nishihiro S, Hiramatsu M, Hishikawa T, Date I

    Journal of Neuroendovascular Therapy   12 ( 9 )   463 - 468   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • 脳神経外科脊椎脊髄外来における漢方薬の使用 査読

    安原隆雄、伊達 勲

    脳神経外科と漢方   4   54 - 56   2018年9月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 高度救命救急センター発足後5年間で、救急搬送され開頭血腫除去術を受けた頭部外傷症例─予後良好群の特徴─ 査読

    安原隆雄、菱川朋人、亀田雅博、黒住和彦、伊達 勲

    神経外傷   41 ( 1 )   33 - 35   2018年9月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Coil Embolization through Collateral Pathway for Ruptured Vertebral Artery Dissecting Aneurysm with Bilateral Vertebral Artery Occlusion. 査読 国際誌

    Satoshi Murai, Kenji Sugiu, Tomohito Hishikawa, Masafumi Hiramatsu, Shingo Nishihiro, Naoya Kidani, Yu Takahashi, Isao Date

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   27 ( 9 )   e215-e218   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:W.B. Saunders  

    DOI: 10.1016/j.jstrokecerebrovasdis.2018.04.036

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  • [Devices and Practices for Improving the Accuracy of Deep Brain Stimulation].

    Tatsuya Sasaki, Takashi Agari, Isao Date

    No shinkei geka. Neurological surgery   46 ( 9 )   751 - 762   2018年9月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.11477/mf.1436203809

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  • δ-cateninはbevacizumab誘導性glioma浸潤を調整する

    清水 俊彦, 黒住 和彦, 石田 穣治, 大谷 理浩, 冨田 祐介, 服部 靖彦, 畝田 篤仁, 松本 悠司, 市川 智継, 伊達 勲

    Brain Tumor Pathology   35 ( Suppl. )   185 - 185   2018年9月

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    記述言語:日本語   出版者・発行元:日本脳腫瘍病理学会  

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  • Midline gliomaの遺伝子変異と長期治療成績の検討

    服部 靖彦, 黒住 和彦, 藤井 謙太郎, 清水 俊彦, 冨田 祐介, 畝田 篤仁, 松本 悠司, 坪井 伸成, 柳井 広之, 伊達 勲

    Brain Tumor Pathology   35 ( Suppl. )   134 - 134   2018年9月

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    記述言語:日本語   出版者・発行元:日本脳腫瘍病理学会  

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  • 腫瘍溶解ウイルスRAMBOはbevacizumab誘発性グリオーマ浸潤を抑制する

    冨田 祐介, 黒住 和彦, 松本 悠司, 服部 靖彦, 清水 俊彦, 大谷 理浩, 藤井 謙太郎, 市川 智継, Balveen Kaur, 伊達 勲

    Brain Tumor Pathology   35 ( Suppl. )   138 - 138   2018年9月

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    記述言語:日本語   出版者・発行元:日本脳腫瘍病理学会  

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  • 悪性神経膠腫におけるYAP/TAZによるCCN1発現誘導の役割

    畝田 篤仁, 黒住 和彦, 藤村 篤史, 藤井 謙太郎, 清水 俊彦, 冨田 祐介, 服部 靖彦, 松本 悠司, 坪井 伸成, 伊達 勲

    Brain Tumor Pathology   35 ( Suppl. )   140 - 140   2018年9月

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    記述言語:日本語   出版者・発行元:日本脳腫瘍病理学会  

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  • 診断に苦慮した抗MOG抗体陽性脳幹部腫瘤性病変の一例

    藤井 謙太郎, 黒住 和彦, 清水 俊彦, 松本 菜見子, 佐藤 恒太, 阿部 康二, 高橋 利幸, 金子 仁彦, 伊達 勲

    Brain Tumor Pathology   35 ( Suppl. )   194 - 194   2018年9月

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    記述言語:日本語   出版者・発行元:日本脳腫瘍病理学会  

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  • 乳児脳室外上衣下巨細胞性星細胞腫の一例

    坪井 伸成, 黒住 和彦, 佐々木 達也, 柳井 広之, 伊達 勲

    Brain Tumor Pathology   35 ( Suppl. )   166 - 166   2018年9月

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    記述言語:日本語   出版者・発行元:日本脳腫瘍病理学会  

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  • NTRK遺伝子融合を有する高悪性度glioneuronal tumorの1例

    黒住 和彦, 中野 嘉子, 石田 穣治, 田中 健大, 土居 正知, 平戸 純子, 吉田 朗彦, 市村 幸一, 柳井 広之, 伊達 勲

    Brain Tumor Pathology   35 ( Suppl. )   171 - 171   2018年9月

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    記述言語:日本語   出版者・発行元:日本脳腫瘍病理学会  

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  • Cell encapsulation enhances antidepressant effect of the mesenchymal stem cells and counteracts depressive-like behavior of treatment-resistant depressed rats. 査読 国際誌

    Kyohei Kin, Takao Yasuhara, Masahiro Kameda, Yousuke Tomita, Michiari Umakoshi, Ken Kuwahara, Ittetsu Kin, Naoya Kidani, Jun Morimoto, Mihoko Okazaki, Tatsuya Sasaki, Naoki Tajiri, Cesario V Borlongan, Isao Date

    Molecular psychiatry   25 ( 6 )   1202 - 1214   2018年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Despite the advances in pharmacological therapies, only the half of depressed patients respond to currently available treatment. Thus, the need for further investigation and development of effective therapies, especially those designed for treatment-resistant depression, has been sorely needed. Although antidepressant effects of mesenchymal stem cells (MSCs) have been reported, the potential benefit of this cell therapy on treatment-resistant depression is unknown. Cell encapsulation may enhance the survival rate of grafted cells, but the therapeutic effects and mechanisms mediating encapsulation of MSCs remain unexplored. Here, we showed that encapsulation enhanced the antidepressant effects of MSCs by attenuating depressive-like behavior of Wistar Kyoto (WKY) rats, which are considered as a promising animal model of treatment-resistant depression. The implantation of encapsulated MSCs (eMSCs) into the lateral ventricle counteracted depressive-like behavior and enhanced the endogenous neurogenesis in the subventricular zone (SVZ) and the dentate gyrus (DG) of the hippocampus, whereas the implantation of MSCs without encapsulation or the implantation of eMSCs into the striatum did not show such ameliorative effects. eMSCs displayed robust and stable secretion of vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor, fibroblast growth factor-2, and ciliary neurotrophic factor (CNTF), and the implantation of eMSCs into the lateral ventricle activated relevant pathways associated with these growth factors. Additionally, eMSCs upregulated intrinsic expression of VEGF and CNTF and their receptors. This study suggests that the implantation of eMSCs into the lateral ventricle exerted antidepressant effects likely acting via neurogenic pathways, supporting their utility for depression treatment.

    DOI: 10.1038/s41380-018-0208-0

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  • Comparative Histologic and Molecular Analysis of 2 Recurrent Lesions Showing Different Magnetic Resonance Imaging Responses After Bevacizumab Treatment: Report of a Case of Anaplastic Astrocytoma. 査読 国際誌

    Yoshihiro Otani, Tomotsugu Ichikawa, Atsuhito Uneda, Kazuhiko Kurozumi, Joji Ishida, Isao Date

    World neurosurgery   116   464 - 471   2018年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier Inc.  

    BACKGROUND: We report the case of a patient with anaplastic astrocytoma whose 2 recurrent lesions showed different imaging responses from one another after bevacizumab treatment. Histologic and genetic features of this patient are also described. CASE DESCRIPTION: A 31-year-old patient with left temporal anaplastic astrocytoma had surgery, local radiotherapy, and chemotherapy. Recurrent lesions appeared in the cerebellar vermis and left cerebellar hemisphere, and the patient was started on biweekly bevacizumab. Subsequently, the 2 enhanced lesions showed different response patterns on magnetic resonance imaging. Although the lesion in the cerebellar vermis showed an enlargement of enhancing mass, the lesion in the left cerebellar hemisphere showed disappearance of enhancement. We resected the cerebellar vermis lesion and performed biopsy on the cerebellar hemisphere lesion. The specimens were investigated. Both recurrent lesions showed higher Ki-67 labeling indices and pericyte proliferation, and less angiogenesis compared with the initial specimen. Transmission electron microscopy showed a reduction in the distance between the endothelial cells and tumor cells in both recurrent lesions, compared with the initial lesion. However, the tight junctions in the vermian lesion were still disrupted compared with the initial lesion and the cerebellar hemispheric lesion. Genetic analysis of the initial specimen showed proneural signature; however, the recurrent vermian lesion exhibited decreased expression of proneural markers. CONCLUSIONS: We report a case of anaplastic astrocytoma with 2 different imaging responses to bevacizumab. Our analysis suggests that differences in tight junctions possibly contributed to the changes on magnetic resonance imaging observed after bevacizumab treatment.

    DOI: 10.1016/j.wneu.2018.05.036

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  • Hemodynamic features of offending vessels at neurovascular contact in patients with trigeminal neuralgia and hemifacial spasm. 査読 国際誌

    Toru Satoh, Takanobu Yagi, Keisuke Onoda, Masahiro Kameda, Tatsuya Sasaki, Tomotsugu Ichikawa, Isao Date

    Journal of neurosurgery   1 - 7   2018年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVEOffending vessels at the site of neurovascular contact (NVC) in patients with trigeminal neuralgia (TN) and hemifacial spasm (HFS) may have specific hemodynamic features. The purpose of this study was to investigate the wall shear stress (WSS) of offending vessels at NVCs by conducting a computational fluid dynamics (CFD) analysis.METHODSThe authors retrospectively analyzed the cases of 20 patients (10 with TN and 10 with HFS) evaluated by 3D CT angiography and used the imaging findings for analysis of the hemodynamic parameters. The 3D CFD images were directly compared with the NVCs determined by simulated multifusion images of CT angiogram and MR cisternogram, and operative photos. The magnitudes of the WSS (WSSm) at the proximal (WSSm-p), just-beginning (WSSm-j), contact site (WSSm-s), and distal (WSSm-d) areas of each NVC were analyzed. The ratios of the WSSm-j, WSSm-s, and WSSm-d areas to the WSSm-p area were calculated individually. The direction of the WSS (WSSv) and its temporal variation (WSSvV) were depicted and morphologically compared with the NVC confirmed by simulated images and operative findings.RESULTSThe ratios of WSSm at the just-beginning and the contact site to the proximal area of the NVCs (WSSm-j/WSSm-p and WSSm-s/WSSm-p) were both significantly higher than that at the distal area (WSSm-d/WSSm-p) (p < 0.05). The WSSv and WSSvV at the NVCs showed small variation in a single cardiac cycle, especially along the areas that were in contact with the affected nerve.CONCLUSIONSAreas of relatively high WSSm and temporal variation of WSSm (WSSmV) were observed at the NVCs. Less mobility of the WSSv and WSSvV was detected along the side of the vessels in contact with the nerves. These findings may be consistent with the actual area of the NVC. Hemodynamic features of the site of NVC can be added to the preoperative simulation for MVD surgery, which may be useful for the diagnosis and treatment planning of TN and HFS.

    DOI: 10.3171/2018.1.JNS172544

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  • Efficacy of Dural Sealant System for Preventing Brain Shift and Improving Accuracy in Deep Brain Stimulation Surgery.

    Tatsuya Sasaki, Takashi Agari, Ken Kuwahara, Ittetsu Kin, Mihoko Okazaki, Susumu Sasada, Aiko Shinko, Masahiro Kameda, Takao Yasuhara, Isao Date

    Neurologia medico-chirurgica   58 ( 5 )   199 - 205   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The success of deep brain stimulation (DBS) depends heavily on surgical accuracy, and brain shift is recognized as a significant factor influencing accuracy. We investigated the factors associated with surgical accuracy and showed the effectiveness of a dural sealant system for preventing brain shift in 32 consecutive cases receiving DBS. Thirty-two patients receiving DBS between March 2014 and May 2015 were included in this study. We employed conventional burr hole techniques for the first 18 cases (Group I) and a dural sealant system (DuraSeal) for the subsequent 14 cases (Group II). We measured gaps between the actual positions of electrodes and the predetermined target positions. We then retrospectively evaluated the factors involved in surgical accuracy. The average gap between an electrode's actual and target positions was 1.55 ± 0.83 mm in all cases. Postoperative subdural air volume e, the only factor associated with surgical accuracy (r = 0.536, P < 0.0001), was significantly smaller in Group II (Group I: 43.9 ± 27.7, Group II: 12.1 ± 12.5 ml, P = 0.0006). The average electrode position gap was also significantly smaller in Group II (Group I: 1.77 ± 0.91, Group II: 1.27 ± 0.59 mm, P = 0.035). Use of a dural sealant system could significantly reduce intracranial air volume, which should improve surgical accuracy.

    DOI: 10.2176/nmc.oa.2017-0242

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  • The Factors Affecting the Difficulty of Percutaneous Cylindrical Electrode Placement for Spinal Cord Stimulation. 国際誌

    Kyohei Kin, Takashi Agari, Takao Yasuhara, Yousuke Tomita, Ken Kuwahara, Ittetsu Kin, Michiari Umakoshi, Jun Morimoto, Mihoko Okazaki, Tatsuya Sasaki, Isao Date

    World neurosurgery   113   e391-e398   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: Optimal placement of electrodes is important for spinal cord stimulation. Factors affecting the difficulty of percutaneous electrode placement are not well known. In this study, we retrospectively evaluated the factors affecting the difficulty of percutaneous electrode placement. METHODS: We performed a retrospective analysis of 90 consecutive procedures of percutaneous cylindrical electrode implantation at the first author's institution. Age, sex, smoking state, body mass index, the duration of time from the beginning of pain syndrome to operation, diagnosis, the number of previous electrode placements, the previous electrode implantation period, the presence of axial low back pain, the electrode tip level, the pattern of electrode placement, and the reason for reimplantation were selected as factors associated with the success of electrode placement or the operation time of electrode placement. RESULTS: The number of previous electrode placements and the electrode tip level were independently associated with the operation time of electrode placement. According to both univariable and multivariable regression analyses, 1 previous electrode placement lengthened the operation time by approximately 15 minutes. No factors were significantly associated with the success of electrode placement. The more frequently that previous electrode placement was performed, the more difficult electrode placement tended to be. However, electrode reimplantation can be successful given extra time. CONCLUSIONS: This is the first study to evaluate factors affecting the difficulty of percutaneous electrode placement. A history of percutaneous cylindrical electrode placement did not affect the success of current placement, although it lengthened the operation time.

    DOI: 10.1016/j.wneu.2018.02.040

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  • Outcome of coil embolization for symptomatic unruptured cerebral aneurysms 査読 国際誌

    Nishihiro S, Sugiu K, Hishikawa T, Hiramatsu M, Kidani N, Takahashi Y, Date I

    Journal of Neuroendovascular Therapy   12 ( 4 )   169 - 174   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • 小児midline gliomaに対する外科治療の役割と成績

    黒住 和彦, 亀田 雅博, 藤井 謙太郎, 清水 俊彦, 市川 智継, 伊達 勲

    小児の脳神経   43 ( 2 )   187 - 187   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経外科学会  

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  • 結節性硬化症SEGAに対するmTOR阻害薬エベロリムスの使用経験

    市川 智継, 清水 俊彦, 黒住 和彦, 藤井 謙太郎, 伊達 勲

    小児の脳神経   43 ( 2 )   261 - 261   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経外科学会  

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  • 高齢者パーキンソン病に対する脳深部刺激療法─review─ 査読

    佐々木達也、安原隆雄、亀田雅博、上利 崇、伊達 勲

    Geriatric Neurosurgery   30   47 - 51   2018年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 高齢者未破裂脳動脈瘤の自然歴と治療成績 査読

    菱川朋人、伊達 勲

    Geriatric Neurosurgery   30   41 - 44   2018年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Spinal Extradural Arachnoid Cyst: Significance of Intrathecal Infusion after Fistula Closure.

    Michiari Umakoshi, Takao Yasuhara, Atsuhiko Toyoshima, Susumu Sasada, Akira Kusumegi, Jun Morimoto, Kyohei Kin, Yousuke Tomita, Isao Date

    Acta medica Okayama   72 ( 1 )   73 - 76   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The spinal extradural arachnoid cyst is a rare entity. Obtaining the correct diagnosis and detecting the fistula location are critical for providing effective treatment. A 41-year-old man had numbness in the soles of his feet for 2 years with accompanying gait disturbance, and a defecation disorder. Computed tomography myelography performed at another hospital revealed an epidural arachnoid cyst from Th11 to L2. He received a subarachnoid-cyst shunt at the rostral part of the cyst. However, his symptoms worsened and he was admitted to our hospital. Neuroradiological investigations revealed the correct location of the fistula at the level of Th12. We performed partial removal of the cyst wall with fistula closure via right hemilaminectomy of Th11 and 12. The complete closure of the fistula was confirmed by intrathecal infusion of artificial cerebrospinal fluid through the shunt tube. The shunt tube was removed with the sutures. The patient's symptoms improved, although numbness remained in his bilateral heels. There has been no recurrence in 15 months since the surgery. Fistula closure may work as a balanced therapeutic strategy for spinal extradural arachnoid cyst, and intrathecal cerebrospinal fluid infusion is useful for the confirmation of complete fistula closure.

    DOI: 10.18926/AMO/55666

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  • Fibroblast growth factor 13 regulates glioma cell invasion and is important for bevacizumab-induced glioma invasion

    Y Otani, T Ichikawa, K Kurozumi, S Inoue, J Ishida, T Oka, T Shimizu, Y Tomita, Y Hattori, A Uneda, Y Matsumoto, H Michiue, I Date

    Oncogene   37 ( 6 )   777 - 786   2018年2月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1038/onc.2017.373

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  • NADH fluorescence imaging and the histological impact of cortical spreading depolarization during the acute phase of subarachnoid hemorrhage in rats. 査読 国際誌

    Tomohisa Shimizu, Tomohito Hishikawa, Shingo Nishihiro, Yukei Shinji, Yuji Takasugi, Jun Haruma, Masafumi Hiramatsu, Hirokazu Kawase, Sachiko Sato, Ryoichi Mizoue, Yoshimasa Takeda, Kenji Sugiu, Hiroshi Morimatsu, Isao Date

    Journal of neurosurgery   128 ( 1 )   137 - 143   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:American Association of Neurological Surgeons  

    OBJECTIVE Although cortical spreading depolarization (CSD) has been observed during the early phase of subarachnoid hemorrhage (SAH) in clinical settings, the pathogenicity of CSD is unclear. The aim of this study is to elucidate the effects of loss of membrane potential on neuronal damage during the acute phase of SAH. METHODS Twenty-four rats were subjected to SAH by the perforation method. The propagation of depolarization in the brain cortex was examined by using electrodes to monitor 2 direct-current (DC) potentials and obtaining NADH (reduced nicotinamide adenine dinucleotide) fluorescence images while exposing the parietal-temporal cortex to ultraviolet light. Cerebral blood flow (CBF) was monitored in the vicinity of the lateral electrode. Twenty-four hours after onset of SAH, histological damage was evaluated at the DC potential recording sites. RESULTS Changes in DC potentials (n = 48 in total) were sorted into 3 types according to the appearance of ischemic depolarization in the entire hemisphere following induction of SAH. In Type 1 changes (n = 21), ischemic depolarization was not observed during a 1-hour observation period. In Type 2 changes (n = 13), the DC potential demonstrated ischemic depolarization on initiation of SAH and recovered 80% from the maximal DC deflection during a 1-hour observation period (33.3 ± 15.8 minutes). In Type 3 changes (n = 14), the DC potential displayed ischemic depolarization and did not recover during a 1-hour observation period. Histological evaluations at DC potential recording sites showed intact tissue at all sites in the Type 1 group, whereas in the Type 2 and Type 3 groups neuronal damage of varying severity was observed depending on the duration of ischemic depolarization. The duration of depolarization that causes injury to 50% of neurons (P50) was estimated to be 22.4 minutes (95% confidence intervals 17.0-30.3 minutes). CSD was observed in 3 rats at 6 sites in the Type 1 group 5.1 ± 2.2 minutes after initiation of SAH. On NADH fluorescence images CSD was initially observed in the anterior cortex; it propagated through the entire hemisphere in the direction of the occipital cortex at a rate of 3 mm/minute, with repolarization in 2.3 ± 1.2 minutes. DC potential recording sites that had undergone CSD were found to have intact tissue 24 hours later. Compared with depolarization that caused 50% neuronal damage, the duration of CSD was too short to cause histological damage. CONCLUSIONS CSD was successfully visualized using NADH fluorescence. It propagated from the anterior to the posterior cortex along with an increase in CBF. The duration of depolarization in CSD (2.3 ± 1.2 minutes) was far shorter than that causing 50% neuronal damage (22.4 minutes) and was not associated with histological damage in the current experimental setting.

    DOI: 10.3171/2016.9.JNS161385

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  • A case of aspergillotic orbital apex syndrome diagnosed by an additional intraorbital biopsy after nasal endoscopy 査読 国際誌

    Matsumoto N, Sato K, Tadokoro K, Takahashi Y, Yunoki T, Takemoto M, Hishikawa N, Ohta Y, Yamashita T, Fujii K, Ichikawa T, Date I, Abe K

    Neurology and Clinical Neuroscience   6 ( 6 )   188 - 190   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ncn3.12226

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  • Electrical Stimulation Enhances Migratory Ability of Transplanted Bone Marrow Stromal Cells in a Rodent Ischemic Stroke Model. 査読 国際誌

    Jun Morimoto, Takao Yasuhara, Masahiro Kameda, Michiari Umakoshi, Ittetsu Kin, Ken Kuwahara, Kyohei Kin, Mihoko Okazaki, Hayato Takeuchi, Tatsuya Sasaki, Atsuhiko Toyoshima, Naoki Tajiri, Takashi Agari, Cesario V Borlongan, Isao Date

    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology   46 ( 1 )   57 - 68   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND/AIMS: Bone marrow stromal cells (BMSCs) transplantation is an important strategy for the treatment of ischemic stroke. Currently, there are no effective methods to guide BMSCs toward the targeted site. In this study, we investigated the effect of electrical stimulation on BMSCs migration in an ischemic model of rats. METHODS: Adult male Wistar rats weighing 200 to 250 g received right middle cerebral artery occlusion (MCAO) for 90 minutes. BMSCs (2.5×105 cells/ 4 µl PBS) were stereotaxically injected into the left corpus callosum at 1 day after MCAO. After BMSCs injection, a plate electrode with a diameter of 3 mm connected to an implantable electrical stimulator was placed on the right frontal epidural space and a counter electrode was placed in the extra-cranial space. Electrical stimulation at preset current (100 µA) and frequency (100 Hz) was performed for two weeks. Behavioral tests were performed at 1, 4, 8, and 15 days after MCAO using the modified Neurological Severity Score (mNSS) and cylinder test. Rats were euthanized at 15 days after MCAO for evaluation of infarction area and the migration distance and area of BMSCs found in the brain tissue. After evaluating cell migration, we proceeded to explore the mechanisms guiding these observations. MCAO rats without BMSCs transplantation were stimulated with same current and frequency. At 1 and 2 weeks after MCAO, rats were euthanized to evaluate stromal cell-derived factor 1 alpha (SDF-1α) level of brain tissues in the bilateral cortex and striatum. RESULTS: Behavioral tests at 4, 8, and 15 days after MCAO revealed that stimulation group displayed significant amelioration in mNSS and cylinder test compared to control group (p<0.05). Similarly, the infarction areas of stroke rats in stimulation group were significantly decreased compared to control group (p<0.05). Migration distance and area of transplanted BMSCs were significantly longer and wider respectively in stimulation group. An increased concentration gradient of SDF-1α in stimulation group accompanied this enhanced migration of transplanted cells. CONCLUSIONS: These results suggest that electrical stimulation enhances migratory ability of transplanted BMSCs in ischemic stroke model of rats. If we can direct the implanted BMSCs to the site of interest, it may lead to a greater therapeutic effect.

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  • Long-Term Potentiation Enhances Neuronal Differentiation in the Chronic Hypoperfusion Model of Rats. 国際誌

    Hayato Takeuchi, Masahiro Kameda, Takao Yasuhara, Tatsuya Sasaki, Atsuhiko Toyoshima, Jun Morimoto, Kyohei Kin, Mihoko Okazaki, Michiari Umakoshi, Ittetsu Kin, Ken Kuwahara, Yosuke Tomita, Isao Date

    Frontiers in aging neuroscience   10   29 - 29   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Several reports have shown that long-term potentiation (LTP) per se effectively enhances neurogenesis in the hippocampus of intact animals. If LTP can enhance neurogenesis in chronic hypoperfusion, this approach could potentially become a new therapeutic strategy for the restoration of cognitive function and for prevention from deterioration of mild cognitive impairment (MCI). Using an in vivo LTP model of rats, we examined whether LTP per se can enhance neurogenesis in hypoperfusion rats that underwent permanent bilateral common carotid artery occlusion (permanent 2-vessel occlusion, P2VO). High frequency stimulation (HFS) in the subacute phase after P2VO enhanced hippocampal cell proliferation and neurogenesis. However, most enhanced cell proliferation and neurogenesis was seen in the hypoperfusion rats that received HFS and for which LTP could finally be induced. In contrast, the same effect was not seen in the LTP induction in the chronic phase. The present findings, which reveal that most enhanced neurogenesis was seen in hypoperfusion rats for which LTP could be finally induced, could explain the ability of LTP-like activities such as learning paradigms and environmental stimuli to increase the rate of neurogenesis in the hippocampus even under hypoperfusion conditions. Moreover, the present findings, which reveal that LTP induction in the chronic phase after P2VO could not effectively enhance neurogenesis in the hypoperfusion rats, could indicate that patients with MCI and even middle-aged healthy control individuals should start LTP-like activities as early as possible and continue with these activities to prevent age-related deterioration of hippocampal function.

    DOI: 10.3389/fnagi.2018.00029

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  • Combination of the tubular retractor and brain spatulas provides an adequate operative field in surgery for deep-seated lesions: Case series and technical note. 国際誌

    Yoshihiro Otani, Kazuhiko Kurozumi, Joji Ishida, Masafumi Hiramatsu, Masahiro Kameda, Tomotsugu Ichikawa, Isao Date

    Surgical neurology international   9   220 - 220   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background: Surgeries for deep-seated lesions are challenging because making a corridor and observing the interface between lesions and normal brain tissue are difficult. The ViewSite Brain Access System, which is a clear plastic tubular retractor system, is used for resection of deep-seated lesions. However, the tapered shape of this system may result in limitation of the surgical field and cause brain injury to observe the interface between lesions and normal tissue. In this study, we evaluated the usefulness of the combination of ViewSite and brain spatulas. Methods: Nine patients were retrospectively identified who underwent resection of deep-seated lesions with the combination of Viewsite and brain spatulas. We assessed the extent of resection, prognosis, and quantitative brain injury from postoperative diffusion-weighed imaging (DWI). Results: There were four total radiographically confirmed resections. Subtotal resection in four patients and partial resection in one with central neurocytoma were achieved because these tumors were strongly adherent to the choroid plexus and ependymal veins. Only one case of metastatic tumor relapsed 6 months after surgery. The mean postoperative high signal on DWI was 3.68 ± 0.80 cm3. Conclusions: The combination of ViewSite and brain spatulas provides wide and adequate operative fields to observe the interface between lesions and normal tissue, and to prevent brain injury from excessive retraction pressure on the brain derived from repositioning of the ViewSite. Postoperative 3D volumetric analysis shows minimal damage to normal brain tissue. This report may provide new insight into the use of the ViewSite tubular retractor.

    DOI: 10.4103/sni.sni_62_18

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  • 顔面痙攣を呈した椎骨動脈瘤に対して血管内治療を行った一例

    坪井 伸成, 杉生 憲志, 菱川 朋人, 平松 匡文, 西廣 真吾, 木谷 尚哉, 高橋 悠, 村井 智, 伊達 勲

    脳血管内治療   2 ( Suppl. )   S283 - S283   2017年11月

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    記述言語:日本語   出版者・発行元:(NPO)日本脳神経血管内治療学会  

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  • Cell Therapy for Parkinson's Disease. 査読 国際誌

    Takao Yasuhara, Masahiro Kameda, Tatsuya Sasaki, Naoki Tajiri, Isao Date

    Cell transplantation   26 ( 9 )   1551 - 1559   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SAGE PUBLICATIONS INC  

    Cell therapy for Parkinson's disease (PD) began in 1979 with the transplantation of fetal rat dopamine-containing neurons that improved motor abnormalities in the PD rat model with good survival of grafts and axonal outgrowth. Thirty years have passed since the 2 clinical trials using cell transplantation for PD patients were first reported. Recently, cell therapy is expected to develop as a realistic treatment option for PD patients owing to the advancement of biotechnology represented by pluripotent stem cells. Medication using levodopa, surgery including deep brain stimulation, and rehabilitation have all been established as current therapeutic strategies. Strong therapeutic effects have been demonstrated by these treatment methods, but they have been unable to stop the progression of the disease. Fortunately, cell therapy might be a key for true neurorestoration. This review article describes the historical development of cell therapy for PD, the current status of cell therapy, and the future direction of this treatment method.

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  • Dissociated recovery between dementia and parkinsonism by transvenous embolization of recurrent dural arteriovenous fistula

    Yumiko Nakano, Emi Nomura, Masafumi Hiramatsu, Mami Takemoto, Kota Sato, Nozomi Hishikawa, Toru Yamashita, Yasuyuki Ohta, Kenji Sugiu, Isao Date, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   5 ( 5 )   159 - 161   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Dementia and parkinsonism are rarely observed in dural arteriovenous fistula. Here, we report a case of a 63-year-old man with recurrent dural arteriovenous fistula, who developed progressive dementia and parkinsonism as a result of a dural arteriovenous fistula at the torcular herophili. A sinus thrombosis induced the abnormal cortical venous reflux from the isolated straight sinus, resulting in the deep venous congestion of the thalamus and basal ganglia, which led to dementia and parkinsonism. However, the third endovascular embolization ameliorated memory disturbance and apathy with a slight improvement of parkinsonism. Although recoveries from dural arteriovenous fistula-associated neurological deficits are variable depending on the severity, duration and, furthermore, selective vulnerability of the responsible ischemic lesions, early treatment should be essential for better recovery.

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  • midline gliomaの長期治療成績の検討

    服部 靖彦, 黒住 和彦, 藤井 謙太郎, 大谷 理浩, 清水 俊彦, 冨田 祐介, 市川 智継, 柳井 広之, 伊達 勲

    Brain Tumor Pathology   34 ( Suppl. )   100 - 100   2017年5月

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    記述言語:日本語   出版者・発行元:日本脳腫瘍病理学会  

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  • [Molecular targeted drugs in gliomas].

    Kazuhiko Kurozumi, Joji Ishida, Tomotsugu Ichikawa, Isao Date

    Nihon rinsho. Japanese journal of clinical medicine   74 Suppl 7   665 - 671   2016年9月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • [Cilengitide].

    Kazuhiko Kurozumi, Joji Ishida, Tomotsugu Ichikawa, Isao Date

    Nihon rinsho. Japanese journal of clinical medicine   74 Suppl 7   672 - 676   2016年9月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Risk of rupture of unruptured cerebral aneurysms in elderly patients. 国際誌

    Tomoyuki Kawada, Tomohito Hishikawa, Isao Date, Shinjiro Tominari, Akio Morita

    Neurology   86 ( 17 )   1650 - 1650   2016年4月

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  • [Stent-Assisted Coil Embolization of a Dissecting Aneurysm of the Posterior Cerebral Artery: A Case Report].

    Jun Haruma, Kenji Sugiu, Tadato Yukiue, Tatsuya Sasaki, Yasuhiko Hattori, Kazuki Kobayashi, Hideyuki Yoshida, Koji Muneda, Isao Date

    No shinkei geka. Neurological surgery   43 ( 12 )   1099 - 104   2015年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    Dissecting aneurysms of the posterior cerebral artery (PCA) are rare, especially those at the P1 segment. Here, we describe the case of a 57-year-old woman with a subarachnoid hemorrhage (SAH). Computed tomography angiography (CTA) and digital subtraction angiography (DSA) revealed a small (3 mm) dissecting aneurysm with the typical pearl-and-string sign at the right P1 segment. Fourteen days after onset, the patient developed aphasia. DSA revealed vasospasm of the right middle cerebral artery, and we performed endovascular treatment by the intra-arterial injection of 1-(5-isoquinolinesulfonyl) homopiperazine. After this treatment, the patient's symptoms recovered immediately. Vertebral angiography revealed enlargement of the dissecting aneurysm (up to 7 mm diameter). We started a loading dose of 300 mg aspirin and 400 mg clopidogrel after observing growth of the aneurysm. Fifteen days after onset, we performed a stent-assisted coil embolization, and obtained nearly complete obliteration of the aneurysm with preserved patency of the parent artery. Six-month follow-up DSA demonstrated complete occlusion of the aneurysm with good patency of the stented PCA; the patient was at modified Rankin Scale 1. In the treatment of ruptured dissecting aneurysms, parent vessel occlusion (PVO) with aneurysm is common. However, PVO may cause both cerebral infarction of the distal area and perforator occlusion of the occluded vessel. Stent-assisted coil embolization can preserve parent vessel flow and obliterate the aneurysm. Stents offer a therapeutic alternative for PCA dissecting aneurysms, especially when PVO cannot be tolerated.

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  • Prediction model for 3-year rupture risk of unruptured cerebral aneurysms in Japanese patients. 査読 国際誌

    Shinjiro Tominari, Akio Morita, Toshihiro Ishibashi, Tomosato Yamazaki, Hiroyuki Takao, Yuichi Murayama, Makoto Sonobe, Masahiro Yonekura, Nobuhito Saito, Yoshiaki Shiokawa, Isao Date, Teiji Tominaga, Kazuhiko Nozaki, Kiyohiro Houkin, Susumu Miyamoto, Takaaki Kirino, Kazuo Hashi, Takeo Nakayama

    Annals of neurology   77 ( 6 )   1050 - 9   2015年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: To build a prediction model that estimates the 3-year rupture risk of unruptured saccular cerebral aneurysms. METHODS: Survival analysis was done using each aneurysm as the unit for analysis. Derivation data were from the Unruptured Cerebral Aneurysm Study (UCAS) in Japan. It consists of patients with unruptured cerebral aneurysms enrolled between 2000 and 2004 at neurosurgical departments at tertiary care hospitals in Japan. The model was presented as a scoring system, and aneurysms were classified into 4 risk grades by predicted 3-year rupture risk: I, < 1%; II, 1 to 3%; III, 3 to 9%, and IV, >9%. The discrimination property and calibration plot of the model were evaluated with external validation data. They were a combination of 3 Japanese cohort studies: UCAS II, the Small Unruptured Intracranial Aneurysm Verification study, and the study at Jikei University School of Medicine. RESULTS: The derivation data include 6,606 unruptured cerebral aneurysms in 5,651 patients. During the 11,482 aneurysm-year follow-up period, 107 ruptures were observed. The predictors chosen for the scoring system were patient age, sex, and hypertension, along with aneurysm size, location, and the presence of a daughter sac. The 3-year risk of rupture ranged from <1% to >15% depending on the individual characteristics of patients and aneurysms. External validation indicated good discrimination and calibration properties. INTERPRETATION: A simple scoring system that only needs easily available patient and aneurysmal information was constructed. This can be used in clinical decision making regarding management of unruptured cerebral aneurysms.

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  • Tumefactive demyelinating disease mimicking malignant tumor in positron emission tomography with C-11-methionine

    Kosuke Matsuzono, Kentaro Deguchi, Nozomi Hishikawa, Toru Yamashita, Tomotsugu Ichikawa, Isao Date, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   3 ( 2 )   81 - 83   2015年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Tumefactive demyelination is sometimes difficult differentiate from malignant tumors. Positron emission tomography with C-11-methionine is useful for diagnosing cerebral malignant tumors, but there are previous reports for tumefactive demyelination. We experienced a 32-year-old man who suffered from subacute onset dysarthria and left hemiparesis with magnetic resonance image of a large lesion (5.3 x 4.2 cm) in the right frontal lobe. Positron emission tomography with F-18-fluorodeoxyglucose showed a high ring-shaped glucose uptake in the lesion and C-11-methionine showed a remarkable methionine uptake in the whole lesion. Although a malignant tumor was suspected, the patient was finally diagnosed with tumefactive demyelinating disease based on brain biopsy results, and was treated completely by methylpredonisolone therapy. Although C-11-methionine uptake with positron emission tomography commonly suggests a malignant tumor, there can still be a possibility of tumefactive demyelinating disease.

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  • [Cervical spinal dural arteriovenous fistula with rapidly progressive brainstem dysfunction due to venous congestion: a case report]. 査読

    Tatsuya Sasaki, Hiroaki Manabe, Takao Yasuhara, Yasuyuki Miyoshi, Kenji Sugiu, Isao Date

    No shinkei geka. Neurological surgery   43 ( 1 )   51 - 6   2015年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Igaku-Shoin Ltd  

    Spinal dural arteriovenous fistulas(S-dAVFs)are rare vascular malformations of the spine. We experienced a case that presented with rapidly progressive brainstem dysfunction due to venous congestion of cervical dAVFs. A 56-year-old man diagnosed with cervical dAVF four years prior presented with gait disturbance and abnormal thermal nociception on his right side. In addition to the high-intensity lesion from the lower pons to the medulla oblongata on T2-weighted magnetic resonance imaging, diffusion-weighted imaging demonstrated cerebral infarction of the left ventrolateral medulla oblongata. Left vertebral angiography revealed that a feeding artery supplied by the radicular artery at the C4 level formed a fistula with the dilated ascending anterior perimedullary vein. We made a diagnosis of venous congestion due to cervical dAVFs. Numbness on the left upper limb occurred five days after the first symptom. Subsequently, hemiparesis on the left upper limb and swallowing disturbance occurred two weeks after the first symptom. The patient underwent surgical ligation of the dilated abnormal vein, with gradual improvement of his symptoms. Myelopathy due to venous congestion of S-dAVFs usually progresses slowly for several years. However, this case report warns about the possibility that some cases of S-dAVF with rapidly exacerbated symptoms may require prompt therapy.

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  • [The use of the ubiquitin-proteasome system in neurosurgery and the clinical applications of protein therapy].

    Hiroyuki Michiue, Isao Date

    No shinkei geka. Neurological surgery   42 ( 10 )   899 - 906   2014年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • [Spontaneous indirect revascularization through the failed radial artery bypass in a patient with a giant intracavernous internal carotid artery aneurysm]. 査読

    Koji Tokunaga, Tomohito Hishikawa, Kenji Sugiu, Isao Date

    No shinkei geka. Neurological surgery   42 ( 1 )   59 - 64   2014年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • [Anti-HMGB1 antibody therapy for traumatic brain injury and neuropathic pain].

    Yu Okuma, Isao Date, Masahiro Nishibori

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica   143 ( 1 )   5 - 9   2014年1月

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  • Epidemiology of dural arteriovenous fistula in Japan: Analysis of Japanese Registry of Neuroendovascular Therapy (JR-NET2). 査読

    Masafumi Hiramatsu, Kenji Sugiu, Tomohito Hishikawa, Jun Haruma, Koji Tokunaga, Isao Date, Naoya Kuwayama, Nobuyuki Sakai

    Neurologia medico-chirurgica   54 ( 1 )   63 - 71   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN NEUROSURGICAL SOC  

    We developed the Japanese Registry of Neuroendovascular Therapy 2 (JR-NET2) database and used the information for a retrospective, nation-wide multicenter, observational study to clarify the clinical characteristics, current status of procedures, and outcome of patients treated by neuroendovascular therapy in Japan. In this report, we analyzed the clinical characteristics of dural arteriovenous fistulas (dAVFs) in the JR-NET2 database. All patients with dAVFs treated with endovascular therapy in 150 Japanese hospitals were included. Patient characteristics, clinical presentations, and imaging characteristics were analyzed. A total of 1,075 patients with dAVFs underwent 1,520 endovascular procedures. Of 1,075 patients, 45% were men and 55% were women. The mean age was 65 ± 13 years. The most frequent location of dAVFs was the cavernous sinus (43.6%), followed by the transverse-sigmoid sinus (TSS) (33.4%). Twelve percent of the patients had intracranial hemorrhage, 9% had venous infarction, and 3% had convulsion. The statistically significant independent risk factors of intracranial hemorrhage were TSS, superior sagittal sinus (SSS), tentorium, anterior cranial fossa, cranio-cervical junction, cortical venous reflux (CVR), and varix. Risk factors of venous infarction were age older than 60 years, male sex, TSS, SSS, and CVR. Risk factors of convulsion were male sex, SSS, and CVR. This is the largest nationwide report, to date, of the clinical characteristics of dAVFs treated by neuroendovascular therapy. CVR was a major risk factor of aggressive symptoms.

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  • Epidemiology of Dural Arteriovenous Fistula in Japan: Analysis of Japanese Registry of Neuroendovascular Therapy (JR-NET2).

    Masafuni Hiramatsu, Kenji Sugiu, Tomohito Hishikawa, Jun Haruma, Koji Tokunaga, Isao Date, Naoya Kuwayama, Nobuyuki Sakai

    Neurologia medico-chirurgica   54 Suppl 2   63 - 71   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We developed the Japanese Registry of Neuroendovascular Therapy 2 (JR-NET2) database and used the information for a retrospective, nation-wide multicenter, observational study to clarify the clinical characteristics, current status of procedures, and outcome of patients treated by neuroendovascular therapy in Japan. In this report, we analyzed the clinical characteristics of dural arteriovenous fistulas (dAVFs) in the JR-NET2 database. All patients with dAVFs treated with endovascular therapy in 150 Japanese hospitals were included. Patient characteristics, clinical presentations, and imaging characteristics were analyzed. A total of 1,075 patients with dAVFs underwent 1,520 endovascular procedures. Of 1,075 patients, 45% were men and 55% were women. The mean age was 65±13 years. The most frequent location of dAVFs was the cavernous sinus (43.6%), followed by the transverse-sigmoid sinus (TSS) (33.4%). Twelve percent of the patients had intracranial hemorrhage, 9% had venous infarction, and 3% had convulsion. The statistically significant independent risk factors of intracranial hemorrhage were TSS, superior sagittal sinus (SSS), tentorium, anterior cranial fossa, cranio-cervical junction, cortical venous reflux (CVR), and varix. Risk factors of venous infarction were age older than 60 years, male sex, TSS, SSS, and CVR. Risk factors of convulsion were male sex, SSS, and CVR. This is the largest nationwide report, to date, of the clinical characteristics of dAVFs treated by neuroendovascular therapy. CVR was a major risk factor of aggressive symptoms.

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  • [Spinal cord stimulation revisited].

    Takashi Agari, Isao Date

    No shinkei geka. Neurological surgery   41 ( 10 )   851 - 74   2013年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • [Endovascular treatment of basilar artery aneurysms associated with fenestration]. 査読

    Hisakazu Itami, Kenji Sugiu, Masafumi Hiramatsu, Koji Tokunaga, Jun Haruma, Yu Okuma, Tomohito Hishikawa, Ayumi Nishida, Isao Date

    No shinkei geka. Neurological surgery   41 ( 7 )   583 - 92   2013年7月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    Aneurysms at the vertebrobasilar junction are often found with basilar artery(BA)fenestration. We encountered 10 consecutive cases of aneurysms associated with BA fenestration. The purpose of this study is to describe the frequency, clinical features, and outcome of these aneurysms treated by endovascular procedure. The incidence of these aneurysms in our series was 1.9%. All aneurysms were successfully treated by coil embolization. Half of them were treated by using simple technique, and the other half were treated by using adjunctive techniques such as balloon remodeling technique. 70% of these cases were ruptured, and all except one case showed good recovery at the time of discharge. We found 63 reported cases of this aneurysm in the literature between 2000 and 2012. 57 out of 63 aneurysms were treated by endovascular means with good clinical results. The usefulness of endovascular procedure is reported to be superior to surgical clipping because of their anatomical complexity and the difficulty of surgical exposure for clipping. We conclude that outcome of these aneurysms is favorable and endovascular procedure has become their standard treatment for these aneurysms.

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  • [Endovascular treatment for cervical carotid artery aneurysm: a case report]. 査読

    Yasuhiko Hattori, Kenji Sugiu, Tomohito Hishikawa, Koji Tokunaga, Kazuya Takahashi, Isao Date

    No shinkei geka. Neurological surgery   41 ( 6 )   515 - 23   2013年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    We report here a case of cervical carotid artery aneurysm. This 37-year-old male suffered from acute neck swelling when he was taking lunch after physical work. Ultrasonography demonstrated a cervical pseudoaneurysm and a jet flow, which was blowing into the dome from the carotid artery. Angiogram revealed an aneurysm with a diameter of 3 cm at the bifurcation of the common carotid artery. Coil embolization using double-catheter technique was performed and complete occlusion of the aneurysm was obtained without any complications. The patient returned to his normal life. Cervical carotid artery aneurysms are rare and they induce pain by swelling in the neck, hoarseness, swallowing disturbance, hemorrhage, and cerebral ischemia due to embolism. In case of a cervical carotid artery aneurysm, safe and effective treatments are required and endovascular treatment should be considered. Although stent-assisted coil embolization or covered-stent placement were reported as an effective treatment for cervical aneurysms, coil embolization without using a stent was performed in this particular patient who is a young, blue-collar worker because the avoidance of long-term anti-platelet therapy was desirable. Preoperative evaluation is important to select adequate treatment.

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  • [III. Molecular targeting therapy for glioma-bevacizumab and cilengitide].

    Kazuhiko Kurozumi, Manabu Onishi, Tomotsugu Ichikawa, Kentaro Fujii, Jyouji Ishida, Yousuke Shimazu, Isao Date

    Gan to kagaku ryoho. Cancer & chemotherapy   40 ( 6 )   718 - 22   2013年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • [A case of a paraspinal arteriovenous fistula presenting with retroperitoneal hemorrhage treated by staged transarterial and transvenous embolization]. 査読

    Atsuhiko Toyoshima, Koji Tokunaga, Hiroaki Manabe, Kenji Sugiu, Masafumi Hiramatsu, Hisakazu Itami, Tomohito Hishikawa, Isao Date

    No shinkei geka. Neurological surgery   41 ( 5 )   429 - 35   2013年5月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    We report a rare case of a paraspinal arteriovenous fistula(AVF)treated by combined transarterial and transvenous embolization(TAE/TVE). A 72-year-old woman was admitted after a traffic accident. Abdominal enhanced CT disclosed pre-existing large varices at the L3-L4 level in the right retroperitoneum with multiple feeding arteries and veins draining into the extradural venous plexus in the spinal canal. The lesion was diagnosed as a paraspinal AVF. Four days later, the patient went into a state of shock. Emergency abdominal CT showed retroperitoneal hemorrhage due to rupture of the varix. TAE of the feeders from the right L1-L4 arteries was performed, and rebleeding from the varix was prevented. Three months later, follow-up CTA showed regrowth of the AVF, and TVE was performed. Two microcatheters were navigated transvenously into the varix, and detachable coils were delivered into the small compartment just downstream to the shunts, leading to complete obliteration. We conclude that transarterial flow reduction followed by occlusion of the venous side of the shunts is effective to achieve cure of a complex and high-flow paraspinal AVF.

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  • Fatal outcomes of pediatric patients with moyamoya disease associated with pulmonary arterial hypertension. Report of two cases. 査読 国際誌

    Koji Tokunaga, Tomohito Hishikawa, Kenji Sugiu, Isao Date

    Clinical neurology and neurosurgery   115 ( 3 )   335 - 8   2013年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    DOI: 10.1016/j.clineuro.2012.05.002

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  • [A case of synovial sarcoma with brain metastasis treated with surgical resection and stereotactic radiosurgery]. 査読

    Yoshihiro Otani, Tomotsugu Ichikawa, Kazuhiko Kurozumi, Hiroyuki Yanai, Toshiyuki Kunisada, Toshifumi Ozaki, Isao Date

    No shinkei geka. Neurological surgery   41 ( 3 )   255 - 62   2013年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    Synovial sarcomas compromise between 5 to 10% of all soft tissue sarcomas in adults. Synovial sarcoma commonly occurs in the vicinity of the large joints and cranial metastasis is rare. Here, we describe a case with intracranial metastases of a synovial sarcoma. A 41-year-old woman was admitted to our department with sensory aphasia. She had a history of a left inguinal synovial sarcoma and underwent surgery and chemotherapy for primary and metastatic lesions. Head MRI revealed three gadolinium-enhancing lesions in the left frontal, parietal and parietotemporal lobe. Gross total resection was achieved in the left parietotemporal lesion and pathological diagnosis was synovial sarcoma. Two weeks after surgery, she received cyber-knife radiosurgery and her neurological deficit was almost completely resolved. Intracranial metastatic synovial sarcoma is rare. Surgical resection and stereotaxic radiosurgery was very effective in the present case.

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  • [(6)Embolization of cranial dural arteriovenous fistulae and high flow arteriovenous fistulae]. 査読

    Koji Tokunaga, Kenji Sugiu, Isao Date

    No shinkei geka. Neurological surgery   41 ( 2 )   153 - 62   2013年2月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • [Surgical and endovascular treatment for superior cerebellar artery aneurysms: report of two cases]. 査読

    Jun Haruma, Kenji Sugiu, Yosuke Shimazu, Hiroyuki Michiue, Koji Tokunaga, Isao Date

    No shinkei geka. Neurological surgery   41 ( 1 )   45 - 51   2013年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    Aneurysms located on the superior cerebellar artery (SCA) are uncommon and their presentation, natural history, and clinical management are poorly understood. Reports related to the endovascular or surgical management of SCA aneurysms are rare. Herein, we report two cases of SCA aneurysm. The first is that of a 70-year-old woman who presented with subarachnoid hemorrhage (SAH). Surgical treatment (neck clipping) of the ruptured SCA aneurysm was performed, and the flow of the parent artery disappeared. The second is that of a 69-year-old woman with an unruptured SCA aneurysm who underwent endovascular surgery to occlude the parent artery. Neither patients exhibited any additional neurological deficits. SCA aneurysms often have either relatively wide or undefinable necks, so it is difficult to preserve the parent artery. According to several surgical reports, occlusion of the SCA appears well tolerated for a variety of reasons.

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  • [Endovascular coiling of thrombosed basilar tip aneurysm using double stents in a y-configuration]. 査読

    Yoshihiro Otani, Kenji Sugiu, Koji Tokunaga, Tomohito Hishikawa, Hisakazu Itami, Masafumi Hiramatsu, Yu Okuma, Isao Date

    No shinkei geka. Neurological surgery   40 ( 11 )   1005 - 12   2012年11月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    Recent advances in endovascular techniques greatly improved the ability to treat complex cerebral aneurysms. However, patients with wide-necked cerebral aneurysms have posed a special challenge to conventional endovascular therapy. We report a novel method of embolizing wide-necked basilar apex aneurysms by employing a Y-configuration, double stent technique. A 40-year-old woman with a partially thrombosed basilar apex aneurysm transferred to our hospital after diagnosis of subarachnoid hemorrhage. Cerebral angiography revealed a wide-necked aneurysm which neck was incorporating the origins of both the posterior cerebral arteries. In treatment procedure, a microcatheter was inserted into the aneurysm followed by coiling of the upper half of the dome. Next, the first stent was deployed in the right P2 segment extending down to the mid basilar artery and the second stent was then deployed with half of the stent in the left P2 and the other half within the lumen of the previously placed stent. Finally, the microcatheter was withdrawn near the neck, and the rest of the aneurysmal dome was packed by additional coils. The result was favorable. Successful coil embolization of a wide-necked bifurcation aneurysm can be achieved by using the double stenting Y-configuration in this case. This result continues to provide highly encouraging support of this novel technique to treat a subset of complex, wide-necked aneurysms that until recently were considered poor candidates for endovascular therapies.

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  • [Endovascular treatment for basilar tip aneurysms]. 査読

    Kenji Sugiu, Koji Tokunaga, Tomohito Hishikawa, Hisakazu Itami, Yu Okuma, Masafumi Hiramatsu, Jun Haruma, Isao Date

    No shinkei geka. Neurological surgery   40 ( 9 )   765 - 74   2012年9月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    The aim of this study was to analyze the effect of endovascular treatment of basilar (BA) tip aneurysms. The authors performed a retrospective analysis of 79 aneurysms of the BA tip that had been treated using endovascular coil embolization for the last 11 years. Fifty-six patients were women, and 23 were men. The average age of the patients was 63.7 years (range, 35-83 year). The average maximum diameter of the aneurysms was 8.0 mm (range, 2-30 mm). Forty-seven patients (60%) presented with acute subarachnoid hemorrhage (SAH), 1 patient (1%) had an unruptured aneurysm with mass effect, and 31 patients (39%) had incidental aneurysms. Immediate anatomic outcomes demonstrated complete occlusion (CO) in 53 aneurysms (67%), residual neck (RN) in 22 aneurysms (28%), and residual aneurysm (RA) in 4 aneurysms (5%). One patient died from rebleeding 6 hours after the embolization. Another patient suffered from rebleeding 6 years after the initial embolization, and was successfully treated with re-embolization. Four patients suffered from asymptomatic P1 occlusion. No symptomatic complication was observed in the unruptured group. Retreatment was performed in 5 patients, including 4 broad-neck large ruptured aneurysms and 1 giant thrombosed aneurysm. Angiographic and clinical results have been improving in recent cases in this study. Technical advances such as highly compliant balloon remodeling microcatheter and 3D-reconstructed digital angiography contributed to this improvement. Our results indicate that endovascular treatment of BA tip aneurysm is safe and effective. The long-term stability after coil embolization is still a matter of concern. Further improvement is expected.

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  • [Usefulness of endovascular treatment for delayed massive epistaxis following endoscopic endonasal transsphenoidal surgery: a case report]. 査読

    Tetsuo Oka, Kenji Sugiu, Joji Ishida, Tomohito Hishikawa, Shigeki Ono, Koji Tokunaga, Isao Date

    No shinkei geka. Neurological surgery   40 ( 1 )   55 - 60   2012年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    We report here a case of massive nasal bleeding from the sphenopalatine artery three weeks after endonasal transsphenoidal surgery. This 66-year-old male suffered from massive nasal bleeding with the status of hypovolemic shock. Under general anesthesia, an emergent angiography revealed an extravasation from the sphenopalatine artery. Trans-arterial embolization using coil and n-butyl-cyanoacrylate (NBCA) was performed following the diagnostic angiography. Complete occlusion of the injured artery was achieved. The patient showed good recovery from general anesthesia. Delayed nasal bleeding after endonasal transsphenoidal surgery is a rare but important complication. The sphenopalatine artery and its branch are located in the hidden inferior lateral corner of the sphenoid sinus and may be injured during enlargement of the sphenoid opening. When massive delayed nasal bleeding follows transsphenoidal surgery and damage of the internal carotid artery has been ruled out, endovascular treatment of the external carotid artery should be considered.

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  • Nationwide investigation of the current status of therapeutic neuroendoscopy for ventricular and paraventricular tumors in Japan. 査読 国際誌

    Nakamasa Hayashi, Hisayuki Murai, Shoichiro Ishihara, Takayuki Kitamura, Tamotsu Miki, Tomoru Miwa, Masakazu Miyajima, Kenichi Nishiyama, Takayuki Ohira, Shigeki Ono, Tomonari Suzuki, Shingo Takano, Isao Date, Naokatsu Saeki, Shunro Endo

    Journal of neurosurgery   115 ( 6 )   1147 - 57   2011年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER ASSOC NEUROLOGICAL SURGEONS  

    OBJECT: The authors report their investigation on the current status of neuroendoscopic biopsy for ventricular and paraventricular tumors as well as treatment for associated hydrocephalus in Japan. METHODS: Patients who had undergone therapeutic neuroendoscopy between 2005 and 2009 were included in this study. The main items examined were age; sex; localization of tumor; pathological diagnosis using biopsy; the presence, treatment, and efficacy of treatment of associated hydrocephalus; perioperative complications; activities of daily living (ADL) before and after therapeutic neuroendoscopy; and the presence of dissemination during the postoperative course. RESULTS: Seven hundred fourteen patients from 123 sites (462 male and 252 female patients, mean age 33.3 years) were enrolled. Localization of the tumor was mainly classified into the lateral ventricle in 91 patients, the third ventricle in 339, the fourth ventricle in 18, the suprasellar region in 75, and other paraventricular areas in 191 patients. The most commonly observed tumors were germ cell tumors in the third ventricle (177 cases [39%]), cystic lesions in the suprasellar region (56 cases [75%]), and astrocytic tumors in the thalamus-basal ganglia (71 cases [38%]). Although 641 (92.8%) of 691 patients could receive neuroendoscopic diagnosis using biopsy, the diagnosis obtained with endoscopic biopsy differed from the final diagnosis based on subsequent craniotomy in 18 patients and clinical course in 3 patients. Of these 21 patients, 7 had astrocytic tumors, 4 had pineal tumors, 6 had germ cell tumors, and 4 had other tumors. The final diagnostic accuracy rate was 89.7%. Associated hydrocephalus was observed in 517 patients (72.4%), of whom 316 and 39 underwent third ventriculostomy and fenestration of the septum, respectively. The response rates were 96.2% and 89.7%, respectively. Third ventriculostomy was required for recurrence of hydrocephalus in 41 patients (13.0%), and the long-term response rate was therefore 83.2% (263 of 316 patients). Perioperative complications other than fever, such as new onset of or progressive hydrocephalus, infection due to CSF leakage, and bleeding in the ventricle or tumor, were found in 81 patients (11.3%). The median Karnofsky Performance Scale score before endoscopic surgery was 80, but it increased to 90 after surgery. The score was thus significantly increased after surgery (p < 0.0001, Mann-Whitney U-test). Activities of daily living after surgery decreased due to perioperative complications in 15 patients (2.1%). The incidence of new dissemination after endoscopic biopsy was 6.8% and not high compared with routine surgical treatment. CONCLUSIONS: The authors concluded that neuroendoscopic diagnosis using biopsy for ventricular and paraventricular tumors is adequately accurate and safe. It was demonstrated that endoscopic procedures play important roles not only in the treatment of hydrocephalus associated with intra- and paraventricular tumors but also in significantly improving ADL. Furthermore, the long-term outcome of endoscopic third ventriculostomy was clearly favorable.

    DOI: 10.3171/2011.7.JNS101976

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  • [Cavernous sinus dural arteriovenous fistulas treated with percutaneous transvenous embolization using liquid material: two case reports]. 査読

    Masafumi Hiramatsu, Kenji Sugiu, Koji Tokunaga, Ayumi Nishida, Mitsuo Kuriyama, Tomohide Maeshiro, Kaoru Terasaka, Isao Date

    No shinkei geka. Neurological surgery   39 ( 12 )   1189 - 96   2011年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    INTRODUCTION: Percutaneous transvenous embolization (TVE) using coils is a well-established treatment of cavernous sinus dural arteriovenous fistula (CSdAVF). However, it is sometimes difficult to achieve complete occlusion by coil embolization. In these two cases, we were able to obtain complete angiographic obliteration of the fistulas without complications by means of percutaneous TVE using n-butyl-cyanoacrylate (NBCA) after we failed when TVE using coils. Case 1: An 89-year-old woman presented with double vision. She was diagnosed as Barrow type D right CSdAVF draining only to the cortical vein. We treated the patient by TVE using coils, but the microcatheter was withdrawn before complete occlusion was attained. The repositioning of the microcatheter was difficult, so we used 30% NBCA for TVE, and obtained complete obliteration of the fistula. Case 2: An 87-year-old woman presented with right exophthalmos, and chemosis. She was diagnosed as Barrow type C right CSdAVF draining only to the right superior ophthalmic vein with very slow flow. We planned to treat her, using TVE with coils, but we could place only 3 coils and obtained only partial obliteration of the fistula. So we additionally used 25% NBCA for TVE, and obtained complete obliteration of the fistula. CONCLUSION: Compared to TVE using coils, TVE using NBCA gives rise to many problems, but, we can use NBCA as a second option if TVE using coils results in only partial obliteration as in these cases.

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  • Protein therapy using heme-oxygenase-1 fused to a polyarginine transduction domain attenuates cerebral vasospasm after experimental subarachnoid hemorrhage. 査読 国際誌

    Tomoyuki Ogawa, Daniel Hänggi, Yumei Wu, Hiroyuki Michiue, Kazuhito Tomizawa, Shigeki Ono, Hideki Matsui, Isao Date, Hans-Jakob Steiger

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism   31 ( 11 )   2231 - 42   2011年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A sequence of 11 consecutive arginine residues (11R) is one of the best protein transduction domains for introducing proteins into cell membranes. Heme-oxygenase-1 (HO-1) is involved in heme catabolism and reduces the contractile effect of hemoglobin after subarachnoid hemorrhage (SAH). Therefore, we constructed 11R-fused HO-1 protein to achieve successful transduction of the protein into the cerebral arteries and examined the therapeutic effect of the 11R-HO-1 protein for cerebral vasospasm (CV) after SAH. We injected the 11R-HO-1 protein into the cisterna magna of male rats and, several hours after the injection, performed immunofluorescence staining and western blotting analysis of the rat basilar arteries (BAs) to determine transduction efficacy. We also assessed intraarterial HO-1 activity as cGMP (cyclic guanosine 3', 5'-cyclic monophosphate) accumulation in SAH and determined whether protein transduction of 11R-HO-1 quantified the therapeutic effect in a rat double-hemorrhage model of SAH. The BAs expressed significantly more HO-1 in the group injected with 11R-HO-1 (3.56±0.54 (11R-HO-1) versus control (saline)), and transduction of 11R-HO-1 resulted in higher activity (>3.25-fold) in rat BAs with SAH. Moreover, the results of the rat double-hemorrhage model showed that the 11R-HO-1 protein significantly attenuated CV after SAH (317.59±23.48 μm (11R-HO-1) versus 270.08±14.66 μm (11R-fused enhanced green fluorescent protein), 252.05±13.95 μm (saline), P<0.01).

    DOI: 10.1038/jcbfm.2011.87

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  • Guideline for management and treatment of fetal and congenital hydrocephalus: Center Of Excellence-Fetal and Congenital Hydrocephalus Top 10 Japan Guideline 2011. 国際誌

    Shizuo Oi, Takayuki Inagaki, Masaki Shinoda, Satoshi Takahashi, Shigeki Ono, Isao Date, Sadahiro Nomura, Tomoru Miwa, Takashi Araki, Susumu Ito, Hisaaki Uchikado, Osamu Takemoto, Reizo Shirane, Hiroshi Nishimoto, Yuzuru Tashiro, Akira Matsumura

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery   27 ( 10 )   1563 - 70   2011年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    INTRODUCTION: Hydrocephalus does not indicate a single clinical entity, but includes a variety of clinicopathological conditions caused by excessive cerebrospinal fluid (CSF) based on the disturbed circulation. Recent progress in prenatal neuroimagings such as MRI and ultrasound echoencephalography on fetus enables to understand clinicopathological conditions of CSF circulation disorder in conjunction with morphological changes in the central nervous system properly. It has been revealed that the CSF dynamics develop in the theory of evolution from the immature brain, as in the animals with the minor CSF pathway predominance, towards matured adult human brain together with the completion of the major CSF pathway: the "Evolution Theory in CSF Dynamics". Now, we can analyze CSF circulation dynamically and also analyze the flow velocity and direction of CSF movement. CENTER OF EXCELLENCE-FETAL HYDROCEPHALUS TOP 10 JAPAN: Along with this technical improvement, the standards of clinicopathological evaluation of hydrocephalus as well as the classification and concept of hydrocephalus shall undergo a major upgrade. Based on such remarkable improvement in the recent practical diagnostic evaluation of fetal hydrocephalus, it is now required to update the guideline for management and treatment of fetal and congenital hydrocephalus, and a nationwide study group; Center of Excellence-Fetal Hydrocephalus Top 10 Japan, was organized in 2008 in Japan. The retrospective analysis of 333 cases of congenital hydrocephalus indicated a fact that 43% of these cases were diagnosed prenatally, and the majority of cases were treated in these top 10 institutes in Japan. Now, congenital hydrocephalus diagnosed immediately after birth is regarded as to be based on embryonic stage; brain disorder in patients with congenital hydrocephalus should be considered in conjunction with neuronal mature process of embryonic stage. The fact is supported by the current trends in hydrocephalus research represented by "Perspective Classification of Congenital Hydrocephalus" and "Multi-categorical Hydrocephalus Classification". The ultimate goal of hydrocephalus treatment remains achieving arrested hydrocephalus by shunt surgeries. In the future, to achieve arrested hydrocephalus, minimum quantity of CSF to be drained should be elucidated. Consideration for accurate operative indication of ETV along with new neuroendoscopic device development and analysis of CSF circulation is expected in the future. The data in this prospective multicenter analysis in this guideline are credited in Oxford Evidence level 2b (Grade II).

    DOI: 10.1007/s00381-011-1541-7

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  • "Double-stick tape" technique for transposition of an offending vessel in microvascular decompression: technical case report. 査読 国際誌

    Tomotsugu Ichikawa, Takashi Agari, Kazuhiko Kurozumi, Tomoko Maruo, Toru Satoh, Isao Date

    Neurosurgery   68 ( 2 Suppl Operative )   377 - 82   2011年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    BACKGROUND AND IMPORTANCE: Severe hemifacial spasm caused by compression by a tortuous vertebral artery (VA) often is encountered and is difficult to treat. We describe a patient with hemifacial spasm caused by compression of the facial nerve by a tortuous VA. A simple and effective transposition approach, a "double-stick tape" technique, to the offending artery using a fibrin tissue-adhesive collagen fleece product (TachoComb) is reported. CLINICAL PRESENTATION: A 65-year-old woman presented with an 8-year history of right-sided facial spasms, including the orbicularis oculi and orbicularis oris muscles. MRI revealed a tortuous right VA indented into the pontomedullary junction. The right anterior inferior cerebellar artery (AICA) also contacted the proximal portion of the facial nerve. Surgical exploration with standard retrosigmoid craniotomy was performed. The offending VA was dissected away from the pontomedullary junction toward the cranial base. A small piece of TachoComb, with fibrin glue applied on the non-coated side of the fleece to make a "double-stick tape," was then placed on the ventral surface of the VA. Until the glue hardened, the VA was held away from the brainstem onto the dura of the petrous pyramid. After this procedure, AICA transposition was performed. The patient's symptoms were completely resolved immediately after surgery, and she remained asymptomatic at her 1 year follow-up visit. CONCLUSION: The advantage of our "double-stick tape" technique is the simplicity of the procedure. The present technique is a feasible alternative for the treatment of hemifacial spasm caused by a tortuous VA.

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  • Computational fluid dynamics of carotid arteries after carotid endarterectomy or carotid artery stenting based on postoperative patient-specific computed tomography angiography and ultrasound flow data. 査読 国際誌

    Hitoshi Hayase, Koji Tokunaga, Toshio Nakayama, Kenji Sugiu, Ayumi Nishida, Seiji Arimitsu, Tomohito Hishikawa, Shigeki Ono, Makoto Ohta, Isao Date

    Neurosurgery   68 ( 4 )   1096 - 101   2011年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: There are significant differences in the postoperative morphological and hemodynamic conditions of the carotid arteries between carotid artery stenting (CAS) and endarterectomy (CEA). OBJECTIVE: To compare the postoperative rheological conditions after CAS with those after CEA with patch angioplasty (patch CEA) through the use of computational fluid dynamics (CFD) based on patient-specific data. METHODS: The rheological conditions in the carotid arteries were simulated in 2 patients after CAS and in 2 patients after patch CEA by CFD calculations. Three-dimensional reconstruction of the carotid arteries was performed with the images obtained with computed tomography angiography. The streamlines and wall shear stress (WSS) were calculated by a supercomputer. Adequate boundary conditions were determined by comparing the simulation results with ultrasound flow data. RESULTS: CFD was successfully calculated for all patients. The differences between the flow velocities of ultrasound data and those of the simulation results were limited. In the streamline analysis, the maximum flow velocities in the internal carotid artery after patch CEA were around two-thirds of those after CAS. Rotational slow flow was observed in the internal carotid artery bulb after patch CEA. WSS analysis found regional low WSS near the outer wall of the bulb. High WSS was observed at the distal end of the arteriotomy after patch CEA and at the residual stenosis after CAS. CONCLUSION: CFD of postoperative carotid arteries disclosed the differences in streamlines and WSS between CAS and patch CEA. CFD may allow us to obtain adequate rheological conditions conducive to achieving the best clinical results.

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  • OCFC(Okayama craniofacial conference)の現状について

    山口 憲昭, 田中 義人, 山田 潔, 難波 祐三郎, 木股 敬裕, 小野 成紀, 伊達 勲, 山城 隆, 本城 正

    日本形成外科学会会誌   31 ( 3 )   201 - 201   2011年3月

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    記述言語:日本語   出版者・発行元:(一社)日本形成外科学会  

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  • [Vasospasm of Adamkiewicz artery after subarachnoid hemorrhage].

    Yasuyuki Miyoshi, Akihiko Kondo, Takao Yasuhara, Ayumi Nishida, Koji Tokunaga, Kenji Sugiu, Isao Date

    Brain and nerve = Shinkei kenkyu no shinpo   63 ( 2 )   182 - 3   2011年2月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • [Clinical features and management of cavernous and venous angiomas in the head].

    Koji Tokunaga, Isao Date

    Brain and nerve = Shinkei kenkyu no shinpo   63 ( 1 )   17 - 25   2011年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    Cerebral cavernous angiomas consist of well-circumscribed collections of thin-walled sinusoidal vascular channels lacking the intervening brain tissue. They are present in 0.4-0.8% of the population, and can occur in a sporadic or familial form. Most common symptoms are seizures, hemorrhage, and focal neurological deficits. The annual bleeding rate of the patient is reported to be 0.25%-20%. High-resolution magnetic resonance imaging (MRI) is a useful diagnostic tool with a high degree of sensitivity and specificity. Microsurgical excision of the lesion is a good treatment choice for cavernous angiomas in the brain, even in the brainstem. Although stereotactic radiosurgery may reduce the incidence of rebleeding and the frequency of seizures, its indication should be carefully investigated because of the relatively high rate of radiation-induced side effects. Less frequently, cavernous angiomas can be located at the extra-axial regions of the head, which include the cavernous sinus, the orbit, and the cranial nerves. Cavernous angiomas in the cavernous sinus pose a neurosurgical challenge due to the high vascularity and involvement of the neurovascular structures, and stereotactic radiosurgery is considered as an additional option. Surgical resection is recommended for symptomatic cavernous angiomas in the orbit; however, the rate of complications after resection is not necessarily low for cavernous angiomas within the apex. Venous angiomas are anomalies of normal venous drainage, which show characteristic appearance of the drainage system in the late phase of angiography (caput medusae). They are found either alone or in combination with other vascular malformations. Conservative treatment is recommended except for patients with a large hematoma or with a coexisting cavernous angioma.

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  • [Mist irrigation system at drilling in spinal surgery].

    Takao Yasuhara, Yasuyuki Miyoshi, Isao Date

    No shinkei geka. Neurological surgery   38 ( 12 )   1103 - 7   2010年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    The "mist irrigation system" (MIS) is a new and effective method at drilling in spinal surgery. In this report, MIS is introduced with subsequent demonstration that visibility at drilling is better with MIS because of the reduction of smoke, blood and irrigation water. Additionally using a 5 mm-thick acryl plate, the time for perforation by drilling and temperature after drilling with MIS, drip-irrigation (DI) or no irrigation, were measured respectivily. Using the acryl plate significantly reduced drilling time and high temperature after perforation in the group without irrigation were recognized, compared to cases in the groups with MIS or DI. The results might indicate that the high temperature of the drill might melt the acryl plate immediately. As a conclusion, MIS might help surgeons to drill in the deep and narrow operative field. Additionally it might help to reduce the risks of heat injury to neuronal tissue by cooling efficiently.

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  • Percutaneous balloon angioplasty for acute occlusion of intracranial arteries. 査読 国際誌

    Koji Tokunaga, Kenji Sugiu, Kimihiro Yoshino, Yoshinori Terai, Takashi Imaoka, Akira Handa, Nobuyuki Hirotsune, Noboru Kusaka, Isao Date

    Neurosurgery   67 ( 3 Suppl Operative )   ons189-96; discussion ons196-7 - 196   2010年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    BACKGROUND: The benefits of intravenous thrombolysis for acute ischemic stroke are still limited. OBJECTIVE: To evaluate the safety and efficacy of double-lumen balloon catheter-based reperfusion therapy with or without intra-arterial thrombolysis for acute occlusion of intracranial arteries. METHODS: Fifty-nine patients with acute occlusion of intracranial arteries were enrolled. A Gateway balloon catheter was used to disrupt clots or dilate atheromatous plaques in every patient. The technical details, technique-related complications, recanalization rates, and clinical outcomes were analyzed. RESULTS: The occlusion sites were internal carotid arteries in 17 patients, M1 segments in 32 patients, the M2 segment in 1 patient, a vertebral artery in 1 patient, and basilar arteries in 8 patients. Twenty-four patients (41%) were treated with thrombolysis first, and 20 patients (34%) were treated with percutaneous transluminal angioplasty (PTA) followed by thrombolysis. PTA alone was performed in 15 patients (25%). The mean dose of urokinase was 205 x 10 U. The extent of recanalization was complete (Thrombolysis in Myocardial Infarction [TIMI] score of 3) in 17 patients (29%), and partial (TIMI 1/2) in 28 patients (47%). Functional independence at discharge was preserved in 76%, 25%, and 7% of patients with TIMI 3, TIMI 1/2, and TIMI 0, respectively. A combination of PTA and thrombolysis resulted in a significantly higher recanalization rate than PTA only. Seven patients (12%) experienced hemorrhagic events after treatment. Severe parenchymal hemorrhage with neurologic deterioration was observed in 2 patients (4%), and vessel rupture was encountered in 1 atherosclerotic case. CONCLUSIONS: Mechanical angioplasty using a Gateway catheter combined with a low-dose thrombolytic agent is a safe and effective treatment for acute intracranial embolic and atherosclerotic occlusion with a low risk of hemorrhagic complications.

    DOI: 10.1227/01.NEU.0000380954.29925.CE

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  • 岡山大学病院小児頭蓋顔面形成センターにおける頭蓋縫合早期癒合症骨モデル作成による手術シミュレーションの効果と手術成績

    小野 成紀, 安原 隆雄, 山田 潔, 木股 敬裕, 本城 正, 山城 隆, 伊達 勲

    小児の脳神経   35 ( 2 )   212 - 212   2010年4月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経外科学会  

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  • [Clinical standard of neurosurgical disorder (7). Deep brain stimulation for involuntary movement].

    Takashi Agari, Isao Date

    No shinkei geka. Neurological surgery   37 ( 6 )   597 - 607   2009年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • [Clipping for large and giant paraclinoid aneurysm by using suction decompression method: key points at setting and clipping]. 査読

    Isao Date, Koji Tokunaga

    No shinkei geka. Neurological surgery   37 ( 2 )   135 - 46   2009年2月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IGAKU-SHOIN LTD  

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  • Gene therapy for Parkinson's disease. 査読 国際誌

    Takao Yasuhara, Isao Date

    Journal of neural transmission. Supplementum   ( 73 )   301 - 9   2009年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Parkinson's disease is characterized by the degeneration of the nigrostriatal dopaminergic neurons with the manifestation of tremor, rigidity, akinesia, and disturbances of postural reflexes. Medication using L-DOPA and surgeries including deep brain stimulation are the established therapies for Parkinson's disease. Cell therapies are also effective and have rapidly developed with the recent advancement in molecular biological technology including gene transfer. In this review, ex vivo gene therapy using genetically engineered cell transplantation for Parkinson's disease model of animals is described, including catecholamine/neurotrophic factor-secreting cell transplantation with or without encapsulation, as well as in vivo gene therapy using direct injection of viral vector to increase dopamine-production, ameliorate the survival of dopaminergic neurons, correct the deteriorated microenvironment, or normalize genetic abnormality. Furthermore, the future directions for clinical application are described together with recent clinical trials of gene therapy.

    DOI: 10.1007/978-3-211-92660-4_25

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  • 科学的根拠に基づくくも膜下出血診療ガイドライン第2版

    吉峰 俊樹, 伊達 勲, 橋本 信夫, 本郷 一博, 宝金 清博, 河瀬 斌, 嘉山 孝正, 桐野 高明, 木内 博之, 甲村 英二, 宮本 享, 永田 泉, 小川 彰, 佐伯 直勝, 斉藤 勇, 斉藤 延人, 坂井 信幸, 佐野 公俊, 佐々木 富男, 塩川 芳昭, 高橋 明, 滝 和郎, 種子田 護, 冨永 悌二, 上島 弘嗣, 山田 和雄, 山口 武典, 山浦 晶, 吉田 純, 藤中 俊之, 中村 元, 江面 正幸, 藤村 幹, 藤田 敦史, 古屋 一英, 服部 健一, 飯原 弘二, 井上 敬, 柿澤 幸成, 樫村 博史, 片岡 和夫, 北川 直毅, 小林 英一, 近藤 礼, 栗田 浩樹, 間瀬 光人, 宮地 茂, 森田 明夫, 詠田 眞治, 野中 雅, 野崎 和彦, 大坪 亮一, 岡本 奨, 岡村 智教, 小野 成紀, 小野塚 聡, 阪井田 博司, 杉田 正夫, 高木 康志, 梅村 淳, 清水 宏明, 日本脳卒中の外科学会, くも膜下出血診療ガイドライン改訂委員会

    脳卒中の外科   36 ( 増刊 )   1 - 80   2008年12月

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    記述言語:日本語   出版者・発行元:(一社)日本脳卒中の外科学会  

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  • [Moyamoya disease].

    Koji Tokunaga, Isao Date

    Brain and nerve = Shinkei kenkyu no shinpo   60 ( 1 )   37 - 42   2008年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    Moyamoya disease is characterized by progressive steno-occlusive changes at the terminal portions of the bilateral internal carotid arteries with arterial collateral vessels at the base of the brain. As the incidence of moyamoya disease is highest in Japanese and Asians, Japanese researchers have made enormous efforts to illuminate the pathogenesis, the epidemiology, the clinical features and the treatment of this disease for five decades. The disease was called variously according to each researcher's assumption of the pathogenesis in the early period. After presentation of the initial nationwide data summarized by Nishimoto, et al. at the Symposium Neuroradiologicum in Paris in 1967, the disease was named Nishimoto's disease in Europe. Since the publication in the English literature by Suzuki, et al. in 1969, the term "moyamoya disease" has been accepted in the international community. The etiology of moyamoya disease is still unknown. Genetic backgrounds have been suggested in familial moyamoya disease. Angiogenetic cytokines may play a role in progression of steno-occlusive changes and/or angiogenesis of collaterals. The patients with moyamoya disease present with a variety of clinical symptoms, such as ischemic deficits, intracranial hemorrhage, sensory disturbance, involuntary movement, seizures and headache. Ischemic symptoms dominate in children, though intracranial hemorrhage is more common in adults. The ischemic attacks in children are often provoked by hyperventilation. Intracranial hemorrhage is mainly caused by hemodynamic stress on fragile moyamoya vessels. Many surgical options, including indirect bypass, direct bypass and their combination, have been developed to increase cerebral blood flow for patients with ischemic problems. Ongoing studies may elucidate the pathogenesis of the disease and efficacy of bypass surgery for hemorrhagic cases.

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  • Neurotransmitter and neurotrophic factor-secreting cell line grafting for the treatment of Parkinson's disease 査読

    Isao Date, Tetsuro Shingo, Takao Yasuhara

    ADVANCES IN ALZHEIMER'S AND PARKINSON'S DISEASE: INSIGHTS, PROGRESS, AND PERSPECTIVES   57   51 - 56   2008年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:SPRINGER  

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  • [Autologous transplantation of adult derived neural stem cells]. 査読

    Tetsuro Shingo, Takao Yasuhara, Kenichiro Muraoka, Masahiro Kameda, Isao Date

    No shinkei geka. Neurological surgery   35 ( 8 )   823 - 9   2007年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IGAKU-SHOIN LTD  

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  • [Case of a ruptured vertebral artery dissecting aneurysm recanalized after internal trapping]. 査読

    Yoichiro Kikuchi, Kenji Sugiu, Koji Tokunaga, Ayumi Nishida, Takushi Nishimura, Isao Date

    No shinkei geka. Neurological surgery   35 ( 8 )   813 - 9   2007年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IGAKU-SHOIN LTD  

    A 35-year-old male experienced a sudden onset of severe headache. A CT scan revealed subarachnoid hemorrhage. By cerebral angiography, he was diagnosed as having a ruptured right vertebral artery dissecting aneurysm (VADA). It was successfully treated by endovascular occlusion of the affected site, including the aneurysm and parent artery, by using detachable coils. A follow-up angiography obtained seven months after the first treatment revealed the recanalization of the right vertebral artery and dissected aneurysm in an antegrade fashion. A skull X-ray image was useful for detecting the change in appearance of the coils. The second embolization was successfully performed in the same manner. Based on this rare case, the authors emphasize that a careful angiographic analysis and complete internal trapping of the dissecting site are important in the treatment of the ruptured VADA.

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  • [Endovascular treatment of adult pial arteriovenous fistula]. 査読

    Hisakazu Itami, Kenji Sugiu, Koji Tokunaga, Shigeki Ono, Keisuke Onoda, Isao Date

    No shinkei geka. Neurological surgery   35 ( 6 )   599 - 605   2007年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IGAKU-SHOIN LTD  

    The authors report a case of adult pial arteriovenous fistula successfully treated by endovascular glue embolization. A 65-year-old man presented with left hemiparesis and was admitted to the local hospital. Computed tomography scan showed a cerebral hematoma. Cerebral angiography revealed pial single-channel arteriovenous fistula at the right angular artery. An emergent craniotomy was performed and hematoma was successfully evacuated on the next day. Since the post-operative angiography revealed a persisting arteriovenous fistula, the patient was referred to our institute for additional treatment. With the patient under local anesthesia, endovascular treatment was performed through the trans-femoral artery approach A flow-guided microcatheter was successfully navigated just proximal to the fistula site; Histoacryl was then injected, and complete obliteration of the fistula was obtained. The subsequent course was uneventful and the patient returned to his daily life with only very mild left hemiparesis. Endovascular glue embolization plays an important role in the treatment of pial arteriovenous fistula.

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  • [Novel 3D MR angiographic findings of neurovascular compressive sites in patients with trigeminal neuralgia]. 査読

    Toru Satoh, Megumi Omi, Chika Ohsako, Mutsue Nabeshima, Keisuke Onoda, Isao Date

    No shinkei geka. Neurological surgery   35 ( 3 )   259 - 65   2007年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    Neurovascular compressive sites at the root entry zone of the trigeminal nerve were investigated in 25 patients with trigeminal neuralgia by using the fine three-dimensional (3D) magnetic resonance (MR) angiogram, obtained by a 3D time-of-flight, spoiled gradient-recalled sequence. The characteristic 3D MR angiographic findings of the offending vessels were obtained at the neurovascular compressive sites 19/23 (83%), including intermittent MR signal intensity within the vessels in 14/23 (61%), and unclear margin of the vessels in 5/23 (22%). Those abnormal 3D MR angiographic findings were commonly observed at the site of neurovascular compression in conjunction with moderate degree (grade II) and severe degree (grade III) in 19/20 (95%) of the actual nerve compression by the offending vessels. Abnormal findings with 3D MR angiograms may provide flow-related information to suggest a certain neurovascular compression upon the trigeminal nerve by the offending vessels. Those novel 3D MR angiographic findings may be useful for the diagnosis and decision-making process to execute the microvascular decompression surgery in patients with trigeminal neuralgia.

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  • [Neurological disorders and neural regeneration: special reference to Parkinson's disease and cerebral ischemia].

    Isao Date

    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics   44 ( 1 )   72 - 5   2007年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • [Delayed hearing loss after microvascular decompression for hemifacial spasm: report of two cases]. 査読

    Keisuke Onoda, Shigeki Ono, Yasuyuki Miyoshi, Koji Tokunaga, Isao Date

    No shinkei geka. Neurological surgery   34 ( 10 )   1045 - 9   2006年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IGAKU-SHOIN LTD  

    We report two unusual cases of delayed hearing loss after microvascular decompression (MVD) for hemifacial spasm. In the first case, A 59-year-old female noted left hearing loss one week after receiving MVD for left hemifacial spasm. In the second case, A 39-year-old male also noticed ipsilateral hearing loss on the 7th day after MVD for right hemifacial spasm. Both cases were treated by steroid. Two months after the onset, their hearing function improved dramatically. These cases indicated that the delayed hearing loss after MVD for hemifacial spasm can occur, even when gentle microsurgical technique is used, but the prognosis for this condition is fairly good.

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  • [Preoperative assessment of microvascular decompression for hemifacial spasm with fusion imaging of 3D MR cisternogram/angiogram]. 査読

    Keisuke Onoda, Toru Satoh, Yasuyuki Miyosnhi, Koji Tokunaga, Kenji Sugiu, Isao Date

    No shinkei geka. Neurological surgery   34 ( 8 )   785 - 91   2006年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    The preoperative assessment of microvascular decompression (MVD) for hemifacial spasm has been performed with MRI, but assessment of the compressive status by 2D imaging has a number of limitations. We used a fusion image of the 3D MR cisternogram and co-registered 3D MR angiogram, reconstructed from MR cisternogram, obtained by 3D fast spin-echo sequence, and MR angiography, 3D time-of-flight and spoiled-gradient recalled sequences, for the preoperative assessment of the offending artery in 10 patients with hemifacial spasm. The anatomical relationship of the nerve-vessel complex was assessed on the simulated images, and compared with the intraoperative findings. The fusion image of the 3D MR cisternogram/angiogram depicted contours of the brain, nerves, and vessels clearly, and that allowed precise assessment of the pathogenic compression of the facial nerve by the offending vessels, comparative to the operative findings. The fusion imaging of the 3D MR cisternogram/angiogram may provide useful information in the surgical planning of MVD for hemifacial spasm.

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  • [A case of pineal pure germinoma metastasized to the lumbosacral extradural space 8 years after initial therapy. Case report and review of literature].

    Yasuyuki Miyoshi, Masako Omori, Nobuyuki Kobayashi, Toshihiro Masuko, Eiju Watanabe, Isao Date

    No shinkei geka. Neurological surgery   34 ( 7 )   745 - 52   2006年7月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    An 11-year-old boy first presented with a pineal tumor identified by neuroimaging but without positive serum or cerebrospinal fluid markers. The tumor disappeared after the craniotomy and following cranial irradiation. The pathologic diagnosis of the tumor was of a pure germinoma. Eight years later he returned to the hospital with spinal epidural metastasis from the pineal germinoma and required surgery. Intraoperative findings showed that the spinal tumor was solitarily located in the epidural space. Pathologically the tumor was a pure germinoma metastasis. He was treated by a combination of whole spinal irradiation and chemotherapy. The tumor disappeared after the therapy. A pineal germinoma occasionally disseminates through the ventricular system and spinal subarachnoid region. However, a solitary spinal epidural metastasis from pineal germinoma has rarely been reported. Regarding the route of this metastasis, we speculate that the CSF dissemination of the germinoma cells occurred first and some of those cells were trapped in the spinal nerve sleeve and extended into the epidural space.

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  • Encapsulation cell therapy for mucopolysaccharidosis type VII using genetically engineered immortalized human amniotic epithelial cells.

    Hideyuki Nakama, Keiko Ohsugi, Taisuke Otsuki, Isao Date, Motomichi Kosuga, Torayuki Okuyama, Norio Sakuragawa

    The Tohoku journal of experimental medicine   209 ( 1 )   23 - 32   2006年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Mucopolysaccharidosis type VII (MPSVII) is a lysosomal storage disease resulted from a deficiency of the enzyme beta-glucuronidase (GUSB), which is necessary for degradation of glycosaminoglycans (GAGs). The deficiency of GUSB causes progressive accumulation of GAGs and subsequent lysosomal distension in multiple tissues, including the central nervous system (CNS). In murine experiments, bone marrow transplant, enzyme replacement, viral vectors, and genetically modified cells were successfully used for correction of the visceral accumulation of GAGs, but little improvement was seen in the brain, because these therapeutic agents cannot cross the blood-brain barrier (BBB). Although direct intracerebral injection of GUSB-encoding viral vectors has been developed to bypass the BBB, the possibility of tumor formation and the toxicity of over-expressed GUSB have been reported. In this study, we generated immortalized human amniotic epithelial (IHAE) cells to maintain the effect of implantation, and encapsulated these cells to prevent harmful immunological response and tumor formation and to regulate the level of GUSB expression within the host. Moreover, we generated IHAE cells that over-express and secrete human GUSB following transduction with an adenoviral vector encoding human GUSB. Therapeutic efficacy for MPSVII was evaluated in and ex vivo experiments using these encapsulated genetically engineered GUSB-encoding IHAE cells. We confirmed that encapsulated genetically engineered IHAE cells could secrete significant amounts of GUSB outside the capsule in vitro and into the cerebral parenchyma of C3H mice seven days after the capsule implantation. Thus, encapsulation cell therapy using genetically engineered IHAE cells is an effective armamentarium for the treatment of MPSVII.

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  • [Hemifacial spasm due to vascular compression of the distal portion of root exit zone of the facial nerve: report of two cases].

    Keisuke Onoda, Koji Tokunaga, Yasuyuki Miyoshi, Shigeki Ono, Isao Date

    No shinkei geka. Neurological surgery   34 ( 4 )   397 - 400   2006年4月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    It has been generally assumed that only vascular contact at the root exit zone (REZ) of the facial nerve can cause hemifacial spasm. We treated two cases of hemifacial spasm in which compression of the distal site of the REZ of the facial nerve produced symptoms. The microvascular decompression for the patients showed excellent results. Extreme care must be taken not to stretch the internal auditory artery during surgical manipulation. The ABR monitoring is useful to prevent the postoperative hearing loss. It must be kept in mind that the compression of distal portions of the facial nerve may be responsible for hemifacial spasm in cases in which neurovascular compression at the REZ is not confirmed intraoperatively.

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  • [Direct surgery for paraclinoid aneurysm arising from the anterolateral wall of the internal carotid artery]. 査読

    Keisuke Onoda, Koji Tokunaga, Kenji Sugiu, Shigeki Ono, Isao Date

    No shinkei geka. Neurological surgery   34 ( 3 )   267 - 72   2006年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IGAKU-SHOIN LTD  

    The internal carotid aneurysm (ICA) arising from the paraclinoid region is associated with the origins of the superior hypophyseal artery and the ophthalmic artery. Recently, other aneurysms which can arise in this region without imvolvement of the arterial branches has been reported. Among those aneurysms, there are very rare type of aneurysms located on the anterolateral aspect of the internal carotid artery. In this report, we described our experience with direct surgery for five cases of the unruptuted paraclinoid aneurysm arising from the anterolateral aspect of the ICA. Firstly, the common carotid artery was exposed to carry out proximal flow control. We used the pterional approach. The anterior clinoid process was deleted after having confirmed aneurysm and the dural ring was incised. Extreme care had to be taken during this step. All patients underwent successful neck clipping. In recent two cases we employed the neuroendoscope (EndoArm) to observe the unrecognized area of surgical microscope and untrasonic bone curette (SONOPET) to perform the safe removal of the anterior clinoid process. This procedure is very useful for carrying out the neck clipping for aneurysms which are located on the anterolateral aspect of the internal carotid artery.

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  • [Molecular biological features of stem cells in the adult and their application for neuroscience].

    Tetsuro Shingo, Isao Date

    No shinkei geka. Neurological surgery   34 ( 3 )   231 - 53   2006年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • [Percutaneous vertebroplasty combined with radiofrequency ablation for a patient with a spinal metastatic tumor: case report].

    Koji Tokunaga, Kenji Sugiu, Yasuyuki Miyoshi, Hidefumi Mimura, Susumu Kanazawa, Isao Date

    No shinkei geka. Neurological surgery   33 ( 8 )   811 - 5   2005年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    Recent technological development has allowed expanding applications of radiofrequency ablation (RFA) for malignant tumor therapy. We report a case with a spinal metastatic tumor treated with combination of percutaneous vertebroplasty (PVP) that provides pain relief and spinal stabilization and RFA. A 68-year-old male who had undergone resection of left ureteric carcinoma was referred to our hospital with lower back pain due to the fifth lumbar (L5) vertebral metastatic tumor. Conventional radiation therapy was discontinued because of pneumonia. One year later, the patient was admitted again with weakness of the right knee and foot and severe pain of the back and the right lower extremity. Radiographs demonstrated a compressive fracture of the L5 vertebra predominantly on the right side. CT and MRI showed a tumor of the L5 body invading the right pedicle, the intervertebral foramen, and the retroperitoneal space. RFA was performed in the ventral part of the L5 body, and then around the right L5/the first sacral intervertebral foramen. Temperature and time for ablation ranged from 74 degrees C to 95 degrees C and from 11 min. to 30 min., respectively. Next, PVP was performed by the right transpedicular approach. Bone cement was injected into the L5 body and the pedicle by an amount of 3.0 ml in total without technical complications. Postoperatively, visual analogue scale demonstrated decreased pain degree from 10 cm to 5.4 cm. Combined treatment with RFA and PVP is a feasible and promising procedure for spinal metastatic tumors. Further evaluation is necessary to confirm its long-term efficacy.

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  • [Carotid endarterectomy with patch angioplasty].

    Koji Tokunaga, Isao Date

    No shinkei geka. Neurological surgery   33 ( 8 )   759 - 74   2005年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • [Local intraarterial fibrinolysis in central retinal artery occlusion: case report]. 査読

    Masahiko Tagawa, Kenji Sugiu, Kouji Tokunaga, Wataru Sasahara, Kyouichi Watanabe, Nobuo Tamesa, Shigeki Ono, Keisuke Onoda, Isao Date

    No shinkei geka. Neurological surgery   33 ( 6 )   619 - 23   2005年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IGAKU-SHOIN LTD  

    The authors report a case of local intraarterial fibrinolysis (LIF) in central retinal artery occlusion (CRAO). A 79-year-old man with stenosis of the left internal carotid artery (ICA) suffered sudden loss of vision in his left eye. LIF was carried out using a microcatheter in the origin of the ophthalmic artery on the side of the CRAO. Treatment was performed with 120,000 IU of urokinase. After LIF, marked improvement of vision was established. No complication occurred during LIF. One month later, carotid artery stenting was performed for the left ICA stenosis. We consider LIF in CRAO is effective treatment.

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  • [Assessment of the perianeurysmal environment of unruptured internal carotid-posterior communicating artery aneurysms with fusion imaging of three-dimensional magnetic resonance cisternography and angiography]. 査読

    Toru Satoh, Megumi Omi, Chika Ohsako, Atsushi Katsumata, Yusuke Yoshimoto, Shoji Tsuchimoto, Keisuke Onoda, Koji Tokunaga, Kenji Sugiu, Isao Date

    No shinkei geka. Neurological surgery   33 ( 6 )   569 - 77   2005年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    The anatomical relationship of an unruptured internal carotid-posterior communicating artery aneurysm and the perianeurysmal environment was investigated by using three-dimensional (3D) magnetic resonance cisternography (MRC), angiography (MRA) and newly developed fusion images of 3D MRC and 3D MRA. Contact of an aneurysm with the adjacent intra- and pericisternal structures was observed in cases with the aneurysm developing and extending beyond the capacity of the surrounding subarachnoid space. Deformation and bleb formation of the aneurysmal dome was depicted at the dome in contact with the perianeurysmal environment, including the tentorial edge, the anterior petroclinoid dural fold, the oculomotor nerve, the posterior clinoid process, the dorsum sellae and the cranial base bone. By using the fusion imaging technique of 3D MRC and 3D MRA, assessment of the contact of an unruptured cerebral aneurysm with its perianeurysmal environment can be made. Such contact gives ride to risk of deformation and bleb formation of the aneurysmal dome; and may result in cranial nerve symptoms and accelerate rupture from an unruptured cerebral aneurysm.

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  • [Assessment of the signal intensity distribution pattern within the unruptured cerebral aneurysms using color-coded 3D MR angiography]. 査読

    Toru Satoh, Megumi Omi, Chika Ohsako, Atsushi Katsumata, Yusuke Yoshimoto, Shoji Tsuchimoto, Katsuzo Kunishio, Keisuke Onoda, Koji Tokunaga, Kenji Sugiu, Isao Date

    No shinkei geka. Neurological surgery   33 ( 5 )   445 - 54   2005年5月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    To evaluate the interaction between the MR signal intensity distribution pattern and bleb formation/ deformation of the aneurysmal dome, fifty cases of the unruptured cerebral aneurysms were investigated with the color-coded 3D MR angiography. Patterns were categorized into central-type, neck-type and peripheral-type according to the distribution of MR signals with low-, moderate- and high signal intensity areas. Imaging analysis revealed the significant relationship (P < 0.02) of the peripheral-type aneurysms to the bleb formation and deformation of the dome, compared with those of central- and neck-type. Additionally, peripheral-type signal intensity distribution pattern was shown with aneurysms harboring relatively large dome size and lateral-type growth including internal carotid aneurysms. Prospective analysis of intraaneurysmal flow pattern with the color-coded 3D MR angiography may provide patient-specific analysis of intraaneurysmal flow status in relation to the morphological change of the corresponding aneurysmal dome in the management of unruptured cerebral aneurysms.

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  • [Symptomatic unruptured cerebral aneurysms].

    Isao Date, Koji Tokunaga

    No shinkei geka. Neurological surgery   33 ( 3 )   201 - 11   2005年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • [Sequentially occurred bilateral atlantoaxial rotatory subluxation following craniotomy: a case report].

    Yasuyuki Miyoshi, Koji Tokunaga, Isao Date

    No shinkei geka. Neurological surgery   33 ( 1 )   73 - 8   2005年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    Atlanto-axial rotatory subluxation (AARS) often presents in childhood as a stiff, painful neck with associated typical cock-robin type of torticollis. It can occur spontaneously or following minor trauma or an inflammatory process in the cervical tissues or following otorhinolaryngeal surgery. We report a case of bilateral AARS which occurred sequentially following craniotomy. To the best of our knowledge, no case of AARS after craniotomy has been reported previously and only one case in which bilateral AARS was observed has been reported to date. Failure to recognize the condition may result in a fixed rotatory subluxation, which can be difficult to treat. Awareness of this condition by surgeons involved in brain surgery should lead to its early recognition and treatment, preventing a fixed deformity occurring. We discuss the clinical presentation and management of AARS. The literature on this subject is briefly reviewed.

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  • Combination therapy for cerebral vasospasm after SAH: Importance of spinal drainage and Intraarterial injection of fasudil hydrochloride 査読

    S Ono, K Onoda, K Tokunaga, K Sugiu, Date, I

    Proceedings of the 13th World Congress of Neurological Surgery, Vols 1 and 2   379 - 385   2005年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:MEDIMOND S R L  

    Introduction: We hypothesize that the combination therapy of lumbar drainage (LD) with intraarterial injection of Fasudil hydrochloride for cerebral vasospasm (VS) can improve the prognosis of the patients of SAH compared with the therapy of cisternal drainage (CD) with the arterial injection of Fasudil hydrochloride (FH). Materials and Methods: Forty-four patients with aneurysmal SAH who were admitted to our University between January 2003 and April 2005. The treatment group consisted of 30 patients in whom a LD had been placed with intraarterial FH, if necessary, whereas the control group was composed of 14 patients who received the CD with same interventional treatment, if necessary. Age, gender, Hunt and Kosnik grade (H & K), Fisher group, a VS rate, and a rate of normal pressure hydrocephalus (NPH) were compared between these two groups. Primary endpoint was set using Glasgow outcome scale (GOS) after 3 months from onset. Results: There was no difference of age, gender, H & K, and Fisher group between these two groups. Intraarterial FH injection was performed in 20% and 50% of the LD and CD groups, respectively. The rate of angiographic VS in the CD group was significantly higher than that in the LD group (36.7% and 85.7% respectively). Symptomatic VS occurred frequently in the CD group compared with that in the LD group. There was statistically significance between these groups (64.3% vs 23.3%). NPH was noted in 13.3% of the LD group and 42.9% of the CD group. However, regarding GOS there was no statistical difference between these two groups. Conclusions: Although outcome of these groups have no statistical difference, these results indicate that LD was more effective for preventing VS after SAH compared with CD. The combination therapies for VS using LD and intraarterial FH injection can improve the prognosis of VS after SAH, and it should be considered as a new multimodality therapy for the treatment of the patients with SAH.

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  • [Endovascular treatment for ruptured vertebral artery dissecting aneurysms]. 査読

    Kenji Sugiu, Koji Tokunaga, Isao Date

    No shinkei geka. Neurological surgery   32 ( 12 )   1229 - 38   2004年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    Scopus

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  • Complications of embolization for cerebral arteriovenous malformations 査読

    K Sugiu, K Tokunaga, W Sasahara, K Watanabe, A Nishida, S Ono, S Nishio, Date, I, DA Rufenacht

    INTERVENTIONAL NEURORADIOLOGY   10   59 - 61   2004年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:EDIZIONI CENTAURO  

    Embolization is recognized as an important adjunct in the treatment of cerebral arteriovenous malformations (AVMs). We reviewed our results of embolizations for AVMs and discussed procedure-related complications. Eleven complications were recorded in 68 consecutive patients (16%). Of these, four were technical problems including a glued catheter, inability to withdraw the catheter, vessel perforation by the microcatheter, and coil migration. Other complications included three cases of ischemic symptoms due to retrograde thrombosis, two cases of asymptomatic cerebral infarction, one case of asymptomatic small haemorrhage due to venous occlusion, and one case of post-embolization haemorrhage of unknown etiology. Our morbidity rate was 7%, mortality rate was 0%, and asymptomatic complication rate was 9%, retorospectively. Further improvements to endovascular techniques and devices are required.

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  • [A case of lipomatous meningioma].

    Yasuhiro Ono, Shuji Hamazaki, Tomotsugu Ichikawa, Isao Date

    No shinkei geka. Neurological surgery   32 ( 11 )   1167 - 71   2004年11月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    We present a case of a 55-year-old woman with intracranial lipomatous meningioma attached to the left sphenoid ridge. A CT showed a mass lesion partially with a hypodensity area in the left fronto-temporal lobe. On MRI, the mass lesion contained a hyperintensity portion on T1 weighted images, which changed to hypointensity on fat-suppressed-T1 images. Histological examinations demonstrated a transitional meningioma containing lipomatous portions. Immunohistochemical studies showed negative reactivity for epithelial membrane antigen (EMA) and positive reactivity for vimentin and S-100 in the areas with lipomaous foci. This pattern of reactivity was different from that of lipomatous meningiomas reported previously. Further examinations are needed concerning the origin of tumor cells in lipomatous meningiomas.

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  • [Deep brain stimulation for Parkinson's disease].

    Isao Date, Toshihiro Matsui

    No to shinkei = Brain and nerve   56 ( 10 )   827 - 41   2004年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • [Molecular imaging of transgene expression in brain tumors]. 査読

    Tomotsugu Ichikawa, Kinya Terada, Takashi Tamiya, James P Basilion, E Antonio Chiocca, Isao Date

    No shinkei geka. Neurological surgery   32 ( 8 )   805 - 24   2004年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Isolation and transplantation of dopaminergic neurons generated from mouse embryonic stem cells. 査読 国際誌

    Takahito Yoshizaki, Motoki Inaji, Hiroko Kouike, Takuya Shimazaki, Kazunobu Sawamoto, Kiyoshi Ando, Isao Date, Kazuto Kobayashi, Tetsuya Suhara, Yasuo Uchiyama, Hideyuki Okano

    Neuroscience letters   363 ( 1 )   33 - 7   2004年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:1  

    Embryonic stem (ES) cells differentiate into dopamine (DA)-producing neurons when co-cultured with PA6 stromal cells, but the resulting cultures contain a variety of unidentified cells. In order to label live DA neurons in mixed populations, we introduced a GFP reporter under the control of the tyrosine hydroxylase (TH) gene promoter into ES cells. GFP expression was observed in TH-immunoreactive cells that differentiated from the ES cells that carried the TH-GFP reporter gene. DA neurons expressing GFP were sorted from the mixed cell population by fluorescence-activated cell sorting of cells exhibiting GFP fluorescence, and the sorted GFP(+) cells obtained were transplanted into a rat model of Parkinson's disease. Some of these cells survived and innervated the host striatum, resulting in a partial recovery from parkinsonian behavioral defects. This strategy of isolation and transplantation of ES-cell-derived DA neurons should be useful for cellular and molecular studies of DA neurons and for clinical application in the treatment of Parkinson's disease.

    DOI: 10.1016/j.neulet.2004.03.074

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  • [A case of convulsion during selective intra-arterial infusion of fasudil hydrochloride for treatment of vasospasm following subarachnoid hemorrhage]. 査読

    Wataru Sasahara, Shigeki Ono, Koji Tokunaga, Kenji Sugiu, Hiroyuki Nakashimia, Isao Date, Takashi Ohmoto

    No shinkei geka. Neurological surgery   32 ( 5 )   487 - 91   2004年5月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IGAKU-SHOIN LTD  

    The authors report a case of convulsion during intra-arterial selective infusion of fasudil hydrochloride (FSD) for treatment of vasospasm following subarachnoid hemorrhage (SAH). A 47-year-old man (Hunt and Kosnik grade I) presented with sudden onset of headache and was diagnosed with SAH on CT, and admitted to our hospital. Digital subtraction angiography (DSA) performed on admission revealed an anterior communicating artery aneurysm. Neck clipping of the aneurysm was performed on the same day and no neurological deficits were noted postoperatively. Motor aphasia appeared on day 11 after the operation, and emergency DSA revealed vasospasm of the left middle cerebral artery and its branches. Emergency percutaneous transluminal angioplasty was performed with successful dilation of the left M1 artery, and 25 milligrams of FSD was injected into the left M1 artery selectively. During this injection, right hemifacial convulsion appeared, and three minutes later disappeared. No treatment was needed for the seizure. Additional injection of 30 milligrams of FSD into the left internal carotid artery resulted in vasodilatation of the left M1 artery and its branches, improvement of their blood flow on angiography, and recovery from motor aphasia. The patient was discharged 1 month later with no neurological deficits. Intra-arterial selective infusion of FSD plays an important role in treatment for vasospasm following SAH, however, we must be aware of risks of complications such as convulsion.

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  • [Evaluation of the contours and perianeurysmal environment of unruptured cerebral aneurysms, using three-dimensional magnetic resonance cisternogram]. 査読

    Toru Satoh, Chinami Ekino, Chika Ohsako, Atsushi Katsumata, Keisuke Onoda, Shoji Tsuchimoto, Masatoshi Yunoki, Koji Tokunaga, Kenji Sugiu, Isao Date

    No shinkei geka. Neurological surgery   32 ( 3 )   215 - 21   2004年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    To evaluate the anatomical relationship between cerebral aneurysm and the perianeurysmal environment within a cisternal space, the contours of an unruptured cerebral aneurysm and pericisternal structures were depicted on a three-dimensional (3D) MR cisternogram. By using perspective volume-rendering algorithm, the 3D MR cisternograms were reconstructed from the source axial volume data set obtained by the T2-weighted 3D fast spin-echo sequence. Those images were shown together with the coordinated 3D MR angiograms through similar visual projections, and then compared with the intraoperative findings. The outer wall configurations of cerebral aneurysms within the cisternal space were shown in conjunction with the accompanying surface veins, adjacent cranial nerves, dura mater and tentorial edge, cranial base bone, and surrounding pericisternal brain surfaces. With application of 3D MR cisternograms in the management of unruptured cerebral aneurysm, the anatomical relationship between the aneurysmal contours and the perianeurysmal environment could be evaluated the within the cisternal space. This might provide another clinical factor when considering the potential risk of growth, rupture, and symptomatic cranial nerve signs of an unruptured cerebral aneurysm.

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  • [Cell transplantation and regenerative therapy for neurological disorders: treatment for the elderly].

    Isao Date

    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics   41 ( 2 )   168 - 70   2004年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • [Cell transplantation and stereotaxic neurosurgical procedures for therapy of patients with Parkinson's disease].

    Isao Date, Toshihiro Matsui

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   92 ( 8 )   1448 - 55   2003年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • astrocytic tumorにおける19番染色体長腕の遺伝子異常と悪性度との関係

    高尾 聡一郎, 大同 茂, 田宮 隆, 寺田 欣矢, 市川 智継, 小野 泰裕, 伊藤 佐智夫, 大内田 守, 伊達 勲, 清水 憲二

    日本癌学会総会記事   62回   479 - 479   2003年8月

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    記述言語:日本語   出版者・発行元:日本癌学会  

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  • [Percutaneous vertebroplasty--indications and procedural techniques]. 査読

    Koji Tokunaga, Kenji Sugiu, Hiroyuki Nakashima, Isao Date, Takashi Ohmoto, Jean-Baptiste Martin, Daniel A Rüfenacht

    No shinkei geka. Neurological surgery   31 ( 1 )   7 - 14   2003年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IGAKU-SHOIN LTD  

    Web of Science

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  • [Training in neurovascular intervention]. 査読

    Kenji Sugiu, Koji Tokunaga, Isao Date, Takashi Ohmoto

    No shinkei geka. Neurological surgery   30 ( 11 )   1231 - 7   2002年11月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IGAKU-SHOIN LTD  

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  • [Intracerebral grafting of cell line or patient-derived neural stem cells for the treatment of neurological disorders].

    Isao Date, Tetsuro Shingo, Takashi Ohmoto

    Rinsho shinkeigaku = Clinical neurology   42 ( 11 )   1144 - 6   2002年11月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    Due to the development of molecular biology techniques, several types of neurotransmitter or neurotrophic factor secreting cell line can be established. These cell lines were grafted into the brain of animal models of Parkinson's disease and cerebral ischemia after encapsulating into the hollow fiber consisted of semipermeable membrane. Immunological reaction and tumor formation were prevented and functional effects were observed histologically, chemically and behaviorally. Current issues regarding encapsulated cell grafting are: delivery of neurotransmitter and neurotrophic factor simultaneously from one capsule, usage of human-derived cell lines and control of secretion from outside. There are two possible approaches regarding the usage of patient's own neural stem cells for regenerative therapy. Neural stem cells are collected from the subventricular zone of the lateral ventricle and these cells are differentiated into dopaminergic neurons using tyrosine hydroxylase induction cocktail (TH cocktail). Then, these neurons are grafted into the striatum of the patient. Another method is to inject TH cocktail into the patient's striatum in order to induce differentiation of dopaminergic neurons from the neural stem cells in vivo.

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  • Inhibition of poly(ADP-ribose) polymerase attenuates cerebral vasospasm after subarachnoid hemorrhage in rabbits 査読

    M Satoh, Date, I, M Nakajima, K Takahashi, K Iseda, T Tamiya, T Ohmoto, Y Ninomiya, S Asari

    STROKE   32 ( 1 )   225 - 230   2001年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Background and Purpose-Poly(ADP-ribose) polymerase (PARP) is important in modulating inflammation, which has been implicated in cerebral vasospasm after subarachnoid hemorrhage (SAH). We investigated the role of PARP in vasospasm using 3-aminobenzamide (3-AB), a PARP inhibitor, in a rabbit model.
    Methods-Twenty-four New Zealand White rabbits were divided into 4 groups: (1) no treatment (control group, n=6); (2) blood injection without pretreatment (SAH-only group, n=6); (3) blood injection with pretreatment by vehicle (SAH+vehicle group, n = 6); and (4) blood injection with pretreatment by 3-AB (SAH+3-AB group, n=6). We used the single-hemorrhage model of SAH, injecting autologous arterial blood into the cisterna magna. Angiography was performed before (baseline) and after (day 2) SAH, and the diameter of the basilar artery (BA) was measured. Animals were euthanatized after the second angiogram. After perfusion and fixation, the brains were cut into sections for hematoxylin and eosin and immunohistochemical staining for poly(ADP-ribosyl)ation.
    Results-In the control group, there were no differences in the BA lumen caliber between baseline and day 2 (96.8+/-10.4%). Cerebral vasospasm in the SAH+3-AB group (88.2+/-6.2%) was remarkably attenuated in comparison with that in the SAM-only group (64.9+/-8.0%) and the SAH+vehicle group (65.6+/-10.8%). The BA in the SAH+3-AB group showed less corrugation of the tunica elastica interna than that in the SAH-only and SAH+vehicle groups. Staining for poly(ADP-ribosyl)ation was markedly inhibited in smooth muscle and adventitial cells of the BA in the SAH+3-AB group compared with other groups.
    Conclusions-Inhibiting ADP-ribosylation attenuates cerebral vasospasm after SAH in rabbits, and PARP activation may play an important role in the development of cerebral vasospasm.

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▼全件表示

書籍等出版物

  • 今日の治療指針 2021─私はこう治療している─

    福井次矢、高木 誠、小室一成 総編集( 担当: 共著 ,  範囲: 脳腫瘍─神経・筋疾患─)

    医学書院  2021年 

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    総ページ数:2192   担当ページ:960-961   記述言語:日本語

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  • クリニカルガイド小児科 専門医の診断・治療

    水口 雅、山形崇倫 編集( 担当: 共著 ,  範囲: もやもや病ー神経・筋疾患ー)

    南山堂  2021年 

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    総ページ数:912   担当ページ:853-856   記述言語:日本語

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  • 脳神経外科手術のための術後感染症予防 実践マニュアル

    宮本 享 監修 井川房夫、三國信啓、森田明夫 編集( 担当: 共著 ,  範囲: 脊椎脊髄外科領域)

    メジカルビュー  2021年  ( ISBN:9784758318570

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    担当ページ:96-107   記述言語:日本語

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  • 脳神経外科手術 基本主義のバリエーションー手術のWEB動画55本付きー(脳神経外科速報 2021年増刊)

    大宅宗一 監修、竹田理々子 編集( 担当: 共著 ,  範囲: 「超音波手術器派」の立場からー頭蓋底骨削除の方法(ハイスピードドリルまたは超音波手術器))

    メディカ出版  2021年  ( ISBN:9784840473460

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    総ページ数:268   担当ページ:233-236   記述言語:日本語

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  • 今日の治療指針2019年版(Volume 61)

    福井次矢高木 誠、小村一成 総編集( 担当: 共著 ,  範囲: 頭部外傷後遺症─神経・筋疾患─)

    医学書院  2019年 

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    総ページ数:2069   担当ページ:934-935   記述言語:日本語

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    松谷雅生、堀 智勝、浅野孝雄 編集幹事、塩川芳昭、斉藤延人、川原信隆、金 彪 編集( 担当: 共著 ,  範囲: 脳室内病変に対する神経内視鏡手術─テント上病変─)

    メジカルビュー社  2019年 

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    総ページ数:235   担当ページ:46-55   記述言語:日本語

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  • 再生医療の開発戦略と最新研究事例集

    技術情報協会 編集( 担当: 共著 ,  範囲: パーキンソン病における治療の現状と再生医療等製品ニーズ─臓器・器官、疾病ごとの治療・製品ニーズの把握と製品開発─)

    技術情報協会  2019年 

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    総ページ数:420   担当ページ:74-80   記述言語:日本語

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  • 脳腫瘍外科 経験したい手術16─スタンダードからアドバンス─

    中尾直之、井川房夫 編集( 担当: 共著 ,  範囲: 大脳鎌髄膜腫─手術の実際 テント上浅部腫瘍─)

    メジカルビュー社  2019年 

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    総ページ数:355   担当ページ:103-117   記述言語:日本語

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    メジカルビュー社  2019年 

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    総ページ数:173   担当ページ:116-128   記述言語:日本語

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    メディカ出版  2019年 

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    担当ページ:229-230   記述言語:日本語

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    メディカ出版  2019年 

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    担当ページ:231   記述言語:日本語

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    メディカ出版  2019年 

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    担当ページ:232-233   記述言語:日本語

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    メディカ出版  2019年 

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    担当ページ:234-235   記述言語:日本語

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    担当ページ:236-237   記述言語:日本語

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    メジカルビュー社  2019年 

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    総ページ数:183   担当ページ:1-183   記述言語:日本語

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    メジカルビュー社  2019年 

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    総ページ数:183   担当ページ:174-179   記述言語:日本語

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    メジカルビュー社  2019年 

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    メジカルビュー社  2017年  ( ISBN:9784758315692

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    医学書院  2017年  ( ISBN:9784260028097

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    メジカルビュー社  2017年  ( ISBN:9784758315692

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    メジカルビュー社  2016年  ( ISBN:9784753815654

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    Springer International  2015年  ( ISBN:9783319084756

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    にゅーろん社  2014年 

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    南江堂  2012年  ( ISBN:9784524264681

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    医学書院  2012年  ( ISBN:9784260012317

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    InTech  2011年  ( ISBN:9789533077321

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    なるにあ  2011年 

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    Artech House  2011年 

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    にゅーろん社  2010年 

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    メジカルビュー社  2010年  ( ISBN:9784758304276

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    メジカルビュー社  2010年  ( ISBN:9784758311779

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  • Geriatric Neurosurgery Vol.22

    日本老年脳神経外科学会事務局  2010年 

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    診断と治療社  2010年  ( ISBN:9784787817563

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    Springer  2009年 

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    メディカ出版  2009年  ( ISBN:9784840424547

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    椎体形成術研究会  2009年 

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    にゅーろん社  2009年 

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    Springer,New York  2008年 

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    医学書院,東京  2008年 

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    メディカ出版,大阪  2008年 

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    メディカ出版,大阪  2007年 

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    Springer-Verlag Tokyo,Tokyo  2006年 

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    Bologna,Italy  2005年 

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    Thieme Medical Publishers,Inc.,New York  2004年 

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    杏林大学医学部救急医学教室 島崎修次,東京  2004年 

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    Thieme Medical Publishers,Inc.,New York  2004年 

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  • Cerebral Vasospasm Advances in Research and Treatment

    Thieme Medical Publishers,Inc.,New York  2004年 

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  • Cerebral Vasospasm Advances in Research and Treatment

    Thieme Medical Publishers,Inc.,New York  2004年 

     詳細を見る

  • Cerebral Vasospasm Advances in Research and Treatment

    Thieme Medical Publishers,Inc.,New York  2004年 

     詳細を見る

  • 頸椎・頸髄損傷に対する急性期治療のガイドライン

    メジカルビュー社,東京  2004年 

     詳細を見る

  • 先端医療シリーズ30神経内科 神経内科の最新医療

    先端医療技術研究所(東京)  2004年 

     詳細を見る

  • 第24回日本脳神経外科コングレス総会教育ビデオVol.3

    メディカルリサーチセンター,東京  2004年 

     詳細を見る

  • 第24回日本脳神経外科コングレス総会発表ビデオVol.6

    メディカルリサーチセンター,東京  2004年 

     詳細を見る

  • 先端医療シリーズ29・脳神経外科 脳神経外科の最新医療

    先端医療技術研究所,東京  2004年 

     詳細を見る

  • 先端医療シリーズ29・脳神経外科 脳神経外科の最新医療

    先端医療技術研究所,東京  2004年 

     詳細を見る

  • 再生医療と分子イメージング

    放射線医学総合研究所,千葉  2004年 

     詳細を見る

  • Molecular mechanism and epochal therapeutics of ischemic stroke and dementia

    Elsevier Science BV,Amsterdam  2003年 

     詳細を見る

  • 科学的根拠に基づくくも膜下出血診療ガイドライン

    にゅーろん社,仙台  2003年 

     詳細を見る

  • Molecular mechanism and epochal therapeutics of ischemic stroke and dementia

    Elsevier Science BV,Amsterdam  2003年 

     詳細を見る

  • 脳血管障害の最新治療

    先端医療技術研究所,東京  2002年 

     詳細を見る

  • 脳血管障害の最新治療

    先端医療技術研究所,東京  2002年 

     詳細を見る

  • 顕微鏡下手術のための脳神経外科解剖XIV

    サイメッド・パブリケーションズ,東京  2002年 

     詳細を見る

  • 脳血管障害の最新治療

    先端医療技術研究所,東京  2002年 

     詳細を見る

  • 脳血管障害の最新治療

    先端医療技術研究所,東京  2002年 

     詳細を見る

  • 脳血管障害の最新治療

    先端医療技術研究所,東京  2002年 

     詳細を見る

  • 機能的脳神経外科の最先端

    先端医療技術研究所,東京  2002年 

     詳細を見る

  • Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis

    Elsevier  2001年 

     詳細を見る

  • 神経・筋疾患の最新医療

    先端医療技術研究所  2001年 

     詳細を見る

  • 脳血管攣縮vol16

    2001年 

     詳細を見る

  • Proceedings 12th World Congress of Neurosurgery

    2001年 

     詳細を見る

  • 厚生科学研究特定疾患対策研究事業「パーキンソン病の定位脳手術の適応と手術の確立に関する多施設共同研究」平成12年度研究報告書

    2001年 

     詳細を見る

  • Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis

    Elsevier Science BV  2001年 

     詳細を見る

  • Stem Cell Biology and Cellular and Molecular Treatment

    National Center of Neurology and Psychiatry  2000年 

     詳細を見る

  • 脳神経外科の最先端

    先端医療技術研究所  2000年 

     詳細を見る

  • Cerebral Vasospasm VI.

    Oslington Consulting PTY LTD  1999年 

     詳細を見る

  • 脳移植の最前線

    中外医学社  1999年 

     詳細を見る

  • Cerebral Vasospasm VI

    Oslington Consulting PTY LTD  1999年 

     詳細を見る

  • Intracerebral chromaffin cell and encapsulated cell grafting for Parkinson''s disease : a review

    The adrenal chromaffin cell 

     詳細を見る

  • Gene transfer into smooth muscle cells and endothelial cells exposed to hemolysate by adenovirus

     詳細を見る

  • Current status of neural transplantation

     詳細を見る

  • Adrenal medullary chromaffin cell and encapsualted cell grafting into the brain

     詳細を見る

  • Gene therapy for cerebral vasospasm using NF-kB decoy strategy via the cerebrospinal fluid

     詳細を見る

  • The effect of Poly (ADP-ribose) polymerase inhibition on cerebral vasospasm

     詳細を見る

  • Neural transplantation and trophic factors for the treatment of Parkinson''s disease

    Stem Cell Biology and Cellular and Molecular Treatment 

     詳細を見る

  • Cell death by oxyhemoglobin

     詳細を見る

  • Gene induction by adenovirus vector using subarachnoid hem orrhage model in rats

     詳細を見る

  • Cell therapy for Parkinson''s disease using molecular biology techniques

     詳細を見る

  • Cell therapy and gene therapy for neurological disorders

     詳細を見る

  • In vivo analysis of transcription factors in rat basilar artery with cerebral vasospasm after subarachnoid hem orrhage

    Cerebral Vasospasm 

     詳細を見る

  • Gene therapy for cerebral vasospasm using NF-kB decoy strategy via the cerebrospinal fluid

     詳細を見る

  • The effect of spontaneous nitric oxide donor on cerebral vasospasm

     詳細を見る

  • Quantitative and qualitative analysis of hem olysate-induced cerebral vasospasm in rats using corrosion cast technique

    Cerebral Vasospasm 

     詳細を見る

  • Neural transplantation and trophic factors for the treatment of Parkinson''s disease

    Stem Cell Biology and Cellular and Molecular Treatment 

     詳細を見る

  • Effect of aging on cerebral vasospasm after subarachnoid hemorrhage in rabbits

     詳細を見る

  • Gene induction by adenovirus vector using subarachnoid hem orrhage model in rats

     詳細を見る

  • The effect of Poly (ADP-ribose) polymerase inhibition on cerebral vasospasm

     詳細を見る

  • Cell therapy and gene therapy for neurological disorders

     詳細を見る

  • Cell death by oxyhemoglobin

     詳細を見る

  • Cell therapy for Parkinson''s disease using molecular biology techniques

     詳細を見る

  • 副腎髄質と末梢神経の脳内cograftによるパーキンソン病の治療

    神経の再生と機能再建 -基礎と臨床-. 

     詳細を見る

  • 脳移植の最前線(共著)

    脳移植の最前線 

     詳細を見る

  • In vivo analysis of transcription factors in rat basilar artery with cerebral vasospasm after subarachnoid hem orrhage

    Cerebral Vasospasm 

     詳細を見る

  • Corrosion cast techniqueを用いたhemolysateによるラット攣縮脳底動脈の観察

    脳血管攣縮 

     詳細を見る

  • The effect of spontaneous nitric oxide donor on cerebral vasospasm

     詳細を見る

  • Quantitative and qualitative analysis of hem olysate-induced cerebral vasospasm in rats using corrosion cast technique

    Cerebral Vasospasm 

     詳細を見る

  • Gene transfer into smooth muscle cells and endothelial cells exposed to hemolysate by adenovirus

     詳細を見る

  • Current status of neural transplantation

     詳細を見る

  • Adrenal medullary chromaffin cell and encapsualted cell grafting into the brain

     詳細を見る

  • Intracerebral chromaffin cell and encapsulated cell grafting for Parkinson''s disease : a review

    The adrenal chromaffin cell 

     詳細を見る

  • Effect of aging on cerebral vasospasm after subarachnoid hemorrhage in rabbits

     詳細を見る

  • ラットくも膜下出血後の攣縮脳底動脈における転写因子発現の経時的変化について

    脳血管攣縮 

     詳細を見る

  • サル脳血管攣縮モデルに対する遺伝子治寮の試み

    脳血管攣縮 

     詳細を見る

  • 第三脳室腫瘍に対するInterhemispheric Trans-Lamina Terminalis Approach

    顕微鏡下手術のための脳神経外科解剖 

     詳細を見る

  • 松果体および四丘体部への手術到達法と解剖学的指標

    顕微鏡下手術のための脳神経外科解剖IX 

     詳細を見る

  • ラットくも膜下出血モデルを用いたアデノウィルスによる遺伝子導入(共著)

    脳血管攣縮 

     詳細を見る

  • Poly (ADP-ribose) polymerase (PARP) 抑制による脳血管攣縮に対する効果の検討 (共著)

    脳血管攣縮 

     詳細を見る

  • 神経疾患に対する細胞移植・遺伝子療法

    脳神経外科の最先端 

     詳細を見る

  • オキシヘモグロビンによる細胞死について -培養内皮細胞のアポトーシス誘導と培養平滑筋細胞のネクローシス誘導-(共著)

    脳血管攣縮 

     詳細を見る

  • 脳血管攣縮におけるspontaneous nitric oxide donor(FK409)の効果(共著)

    脳血管攣縮 

     詳細を見る

  • 分子生物学を応用したParkinson病に対する細胞療法

    ゲノム時代の脳神経医学 

     詳細を見る

  • 副腎髄質クロム親和細胞およびカプセル化細胞の脳内移植

    定位脳手術 

     詳細を見る

  • 血液存在下での血管平滑筋細胞、内皮細胞へのadenovirusによる遺伝子導入(共著)

    脳血管攣縮 

     詳細を見る

  • 脳脊髄液を介したNF-kBおとり拡核酸による脳血管攣縮の遺伝子治療(共著)

    脳血管攣縮 

     詳細を見る

  • 脳血管攣縮における加齢の影響-塩酸パパベリンに対する反応性の相違による検討-(共著)

    脳血管攣縮 

     詳細を見る

▼全件表示

MISC

  • 三叉神経痛に対して牛車腎気丸および柴苓湯の併用が有効であった1例

    小川敦, 小川敦, 牛尾聡一郎, 亀田雅博, 亀田雅博, 横木梓, 椋田千晶, 江角悟, 渡邊亜津子, 村川公央, 安原隆雄, 北村佳久, 伊達勲, 千堂年昭

    医療薬学   47 ( 8 )   2021年

     詳細を見る

  • Annexin A2-STAT3-Oncostatin M receptor axis drives phenotypic and mesenchymal changes in glioblastoma. 国際誌

    Yuji Matsumoto, Tomotsugu Ichikawa, Kazuhiko Kurozumi, Yoshihiro Otani, Atsushi Fujimura, Kentaro Fujii, Yusuke Tomita, Yasuhiko Hattori, Atsuhito Uneda, Nobushige Tsuboi, Keisuke Kaneda, Keigo Makino, Isao Date

    Acta neuropathologica communications   8 ( 1 )   42 - 42   2020年4月

     詳細を見る

    記述言語:英語  

    Glioblastoma (GBM) is characterized by extensive tumor cell invasion, angiogenesis, and proliferation. We previously established subclones of GBM cells with distinct invasive phenotypes and identified annexin A2 (ANXA2) as an activator of angiogenesis and perivascular invasion. Here, we further explored the role of ANXA2 in regulating phenotypic transition in GBM. We identified oncostatin M receptor (OSMR) as a key ANXA2 target gene in GBM utilizing microarray analysis and hierarchical clustering analysis of the Ivy Glioblastoma Atlas Project and The Cancer Genome Atlas datasets. Overexpression of ANXA2 in GBM cells increased the expression of OSMR and phosphorylated signal transducer and activator of transcription 3 (STAT3) and enhanced cell invasion, angiogenesis, proliferation, and mesenchymal transition. Silencing of OSMR reversed the ANXA2-induced phenotype, and STAT3 knockdown reduced OSMR protein expression. Exposure of GBM cells to hypoxic conditions activated the ANXA2-STAT3-OSMR signaling axis. Mice bearing ANXA2-overexpressing GBM exhibited shorter survival times compared with control tumor-bearing mice, whereas OSMR knockdown increased the survival time and diminished ANXA2-mediated tumor invasion, angiogenesis, and growth. Further, we uncovered a significant relationship between ANXA2 and OSMR expression in clinical GBM specimens, and demonstrated their correlation with tumor histopathology and patient prognosis. Our results indicate that the ANXA2-STAT3-OSMR axis regulates malignant phenotypic changes and mesenchymal transition in GBM, suggesting that this axis is a promising therapeutic target to treat GBM aggressiveness.

    DOI: 10.1186/s40478-020-00916-7

    PubMed

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  • Cerebral circulation improves with indirect bypass surgery combined with gene therapy

    Alex Shear, Shingo Nishihiro, Tomohito Hishikawa, Masafumi Hiramatsu, Kenji Sugiu, Takao Yasuhara, Isao Date

    BRAIN CIRCULATION   5 ( 3 )   119 - 123   2019年7月

     詳細を見る

    記述言語:英語   掲載種別:書評論文,書評,文献紹介等   出版者・発行元:WOLTERS KLUWER MEDKNOW PUBLICATIONS  

    Angiogenesis involves new blood vessels sprouting from preexisting blood vessels. This process may serve to improve brain circulation. Moyamoya disease (MMD) is a cerebrovascular disorder causing intracranial stenosis which significantly reduces the blood supply to the brain. Mainly stroke is the first symptom of the disorder, so treatments that reduce the risk of stroke are used for patients with MMD. To prevent stroke for those with chronic cerebral hypoperfusion, more blood needs to flow to the brain, which was thought to be achieved by enhancing angiogenesis. Indirect bypass surgery, such as encephalo-myo-synangiosis (EMS), is used for revascularization. However, EMS alone sometimes cannot provide enough circulation to avoid ischemic strokes. The current study examined if EMS combined with high-mobility group box-1 (HMGB1) and vascular endothelial growth factor (VEGF) enhanced angiogenesis and increased cerebral circulation. The results indicated that HMGB1 administered with EMS increased angiogenesis through a VEGF-dependent mechanism. In addition, exercising and stem cell transplantation possess possible means to increase angiogenesis. Overall, EMS with gene therapy, maintaining fitness, and stem cell utilization may prevent or help one recover from stroke by enhancing brain angiogenesis. Thus, these treatments may be applicable for patients with MMD. This paper is a review article. Referred literature in this paper has been listed in the references section. The datasets supporting the conclusions of this article are available online by searching various databases, including PubMed.

    DOI: 10.4103/bc.bc_33_19

    Web of Science

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  • 過去7年間におけるてんかん外科症例の治療成績

    松田 奈央子, 秋山 麻里, 佐々木 達也, 伊達 勲, 小林 勝弘

    脳と発達   50 ( 6 )   443 - 443   2018年11月

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    記述言語:日本語   出版者・発行元:(一社)日本小児神経学会  

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  • 病巣切除により発作抑制が得られた乳児結節性硬化症の2例

    佐々木 達也, 上利 崇, 西本 静香, 秋山 麻里, 遠藤 文香, 岡 牧郎, 秋山 倫之, 小林 勝弘, 伊達 勲

    てんかん研究   36 ( 1 )   76 - 76   2018年6月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • 高周波律動(HFO)解析により切除範囲を決定した前頭葉てんかんの1例

    上利 崇, 秋山 倫之, 林 裕美子, 岡 牧郎, 佐々木 達也, 新光 阿以子, 吉永 治美, 伊達 勲

    てんかん研究   36 ( 1 )   70 - 71   2018年6月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • 難治性てんかんで発症したinsular pilocytic astrocytomaの一例

    佐々木 達也, 細本 翔, 岡崎 三保子, 水野 むつみ, 柴田 敬, 秋山 麻里, 亀田 雅博, 安原 隆雄, 小林 勝弘, 伊達 勲

    てんかん研究   36 ( 1 )   88 - 89   2018年6月

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    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • FIBROBLAST GROWTH FACTOR 13 REGULATES GLIOMA CELL INVASION

    Yoshihiro Otani, Tomotsugu Ichikawa, Kazuhiko Kurozumi, Satoshi Inoue, Joji Ishida, Tetsuo Oka, Toshihiko Shimizu, Yusuke Tomita, Yasuhiko Hattori, Atsuhito Uneda, Yuji Matsumoto, Hiroyuki Michiue, Isao Date

    NEURO-ONCOLOGY   19   21 - 21   2017年11月

     詳細を見る

    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:OXFORD UNIV PRESS INC  

    Web of Science

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  • delta-CATENIN REGULATES BEVACIZUMAB-INDUCED GLIOMA INVASION

    Toshihiko Shimizu, Kazuhiko Kurozumi, Joji Ishida, Tetsuo Oka, Yoshihiro Otani, Yusuke Tomita, Yasuhiko Hattori, Atsuhito Uneda, Yuji Matsumoto, Tomotsugu Ichikawa, Isao Date

    NEURO-ONCOLOGY   19   23 - 23   2017年11月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:OXFORD UNIV PRESS INC  

    Web of Science

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  • CORRELATION BETWEEN PIK3R1MET326ILE MUTATION, CYSTEINE-RICH PROTEIN 61 EXPRESSION AND POOR PROGNOSIS IN GLIOBLASTOMA

    Kentaro Fujii, Yoshihiro Otani, Joji Ishida, Kazuhiko Kurozumi, Tetsuo Oka, Toshihiko Shimizu, Yusuke Tomita, Yasuhiko Hattori, Atsuhito Uneda, Yuji Matsumoto, Hiroyuki Michiue, Tomotsugu Ichikawa, Isao Date

    NEURO-ONCOLOGY   19   97 - 97   2017年11月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:OXFORD UNIV PRESS INC  

    Web of Science

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  • 特発性正常圧水頭症のリスク遺伝子SFMBT1

    高橋 賛美, 佐藤 秀則, 公平 瑠奈, 伊関 千書, 加藤 肇, 猪狩 龍祐, 佐藤 裕康, 小山 信吾, 鈴木 匡子, 宮嶋 雅一, 鮫島 直之, 亀田 雅博, 山田 晋也, 喜多 大輔, 貝嶋 光信, 伊達 勲, 桑名 信匡, 加藤 丈夫

    Dementia Japan   31 ( 4 )   558 - 558   2017年10月

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    記述言語:日本語   出版者・発行元:(一社)日本認知症学会  

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  • Combined gene therapy with vascular endothelial growth factor plus apelin in a chronic cerebral hypoperfusion model in rats

    Masafumi Hiramatsu, Tomohito Hishikawa, Koji Tokunaga, Hiroyasu Kidoya, Shingo Nishihiro, Jun Haruma, Tomohisa Shimizu, Yuji Takasugi, Yukei Shinji, Kenji Sugiu, Nobuyuki Takakura, Isao Date

    JOURNAL OF NEUROSURGERY   127 ( 3 )   679 - 686   2017年9月

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    記述言語:英語   出版者・発行元:AMER ASSOC NEUROLOGICAL SURGEONS  

    OBJECTIVE The aim of this study was to evaluate whether combined gene therapy with vascular endothelial growth factor (VEGF) plus apelin during indirect vasoreconstructive surgery enhances brain angiogenesis in a chronic cerebral hypoperfusion model in rats.
    METHODS A chronic cerebral hypoperfusion model induced by the permanent ligation of bilateral common carotid arteries (CCAs; a procedure herein referred to as "CCA occlusion" [CCAO]) in rats was employed in this study. Seven days after the CCAO procedure, the authors performed encephalo-myo-synangiosis (EMS) and injected plasmid(s) into each rat's temporal muscle. Rats were divided into 4 groups based on which plasmid was received (i.e., LacZ group, VEGF group, apelin group, and VEGF+apelin group). Protein levels in the cortex and attached muscle were assessed with enzyme-linked immunosorbent assay (ELISA) on Day 7 after EMS, while immunofluorescent analysis of cortical vessels was performed on Day 14 after EMS.
    RESULTS The total number of blood vessels in the cortex on Day 14 after EMS was significantly larger in the VEGF group and the VEGF+apelin group than in the LacZ group (p &lt; 0.05, respectively). Larger vessels appeared in the VEGF+apelin group than in the other groups (p &lt; 0.05, respectively). Apelin protein on Day 7 after EMS was not detected in the cortex for any of the groups. In the attached muscle, apelin protein was detected only in the apelin group and the VEGF+apelin group. Immunofluorescent analysis revealed that apelin and its receptor, APJ, were expressed on endothelial cells (ECs) 7 days after the CCAO.
    CONCLUSIONS Combined gene therapy (VEGF plus apelin) during EMS in a chronic cerebral hypoperfusion model can enhance angiogenesis in rats. This treatment has the potential to be a feasible option in a clinical setting for patients with moyamoya disease.

    DOI: 10.3171/2016.8.JNS16366

    Web of Science

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  • 早期手術を行い発作抑制が得られた乳児結節性硬化症の2例

    佐々木 達也, 上利 崇, 西本 静香, 秋山 麻里, 遠藤 文香, 岡 牧郎, 秋山 倫之, 小林 勝弘, 伊達 勲

    てんかん研究   35 ( 2 )   588 - 588   2017年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

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  • Combined gene therapy with vascular endothelial growth factor plus apelin in a chronic cerebral hypoperfusion model in rats. 国際誌

    Masafumi Hiramatsu, Tomohito Hishikawa, Koji Tokunaga, Hiroyasu Kidoya, Shingo Nishihiro, Jun Haruma, Tomohisa Shimizu, Yuji Takasugi, Yukei Shinji, Kenji Sugiu, Nobuyuki Takakura, Isao Date

    Journal of neurosurgery   127 ( 3 )   679 - 686   2017年9月

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    記述言語:英語   出版者・発行元:AMER ASSOC NEUROLOGICAL SURGEONS  

    OBJECTIVE The aim of this study was to evaluate whether combined gene therapy with vascular endothelial growth factor (VEGF) plus apelin during indirect vasoreconstructive surgery enhances brain angiogenesis in a chronic cerebral hypoperfusion model in rats. METHODS A chronic cerebral hypoperfusion model induced by the permanent ligation of bilateral common carotid arteries (CCAs; a procedure herein referred to as "CCA occlusion" [CCAO]) in rats was employed in this study. Seven days after the CCAO procedure, the authors performed encephalo-myo-synangiosis (EMS) and injected plasmid(s) into each rat's temporal muscle. Rats were divided into 4 groups based on which plasmid was received (i.e., LacZ group, VEGF group, apelin group, and VEGF+apelin group). Protein levels in the cortex and attached muscle were assessed with enzyme-linked immunosorbent assay (ELISA) on Day 7 after EMS, while immunofluorescent analysis of cortical vessels was performed on Day 14 after EMS. RESULTS The total number of blood vessels in the cortex on Day 14 after EMS was significantly larger in the VEGF group and the VEGF+apelin group than in the LacZ group (p < 0.05, respectively). Larger vessels appeared in the VEGF+apelin group than in the other groups (p < 0.05, respectively). Apelin protein on Day 7 after EMS was not detected in the cortex for any of the groups. In the attached muscle, apelin protein was detected only in the apelin group and the VEGF+apelin group. Immunofluorescent analysis revealed that apelin and its receptor, APJ, were expressed on endothelial cells (ECs) 7 days after the CCAO. CONCLUSIONS Combined gene therapy (VEGF plus apelin) during EMS in a chronic cerebral hypoperfusion model can enhance angiogenesis in rats. This treatment has the potential to be a feasible option in a clinical setting for patients with moyamoya disease.

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  • Combined gene therapy with vascular endothelial growth factor plus apelin in a chronic cerebral hypoperfusion model in rats

    Masafumi Hiramatsu, Tomohito Hishikawa, Koji Tokunaga, Hiroyasu Kidoya, Shingo Nishihiro, Jun Haruma, Tomohisa Shimizu, Yuji Takasugi, Yukei Shinji, Kenji Sugiu, Nobuyuki Takakura, Isao Date

    JOURNAL OF NEUROSURGERY   127 ( 3 )   679 - 686   2017年9月

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    記述言語:英語   出版者・発行元:AMER ASSOC NEUROLOGICAL SURGEONS  

    OBJECTIVE The aim of this study was to evaluate whether combined gene therapy with vascular endothelial growth factor (VEGF) plus apelin during indirect vasoreconstructive surgery enhances brain angiogenesis in a chronic cerebral hypoperfusion model in rats.
    METHODS A chronic cerebral hypoperfusion model induced by the permanent ligation of bilateral common carotid arteries (CCAs; a procedure herein referred to as "CCA occlusion" [CCAO]) in rats was employed in this study. Seven days after the CCAO procedure, the authors performed encephalo-myo-synangiosis (EMS) and injected plasmid(s) into each rat's temporal muscle. Rats were divided into 4 groups based on which plasmid was received (i.e., LacZ group, VEGF group, apelin group, and VEGF+apelin group). Protein levels in the cortex and attached muscle were assessed with enzyme-linked immunosorbent assay (ELISA) on Day 7 after EMS, while immunofluorescent analysis of cortical vessels was performed on Day 14 after EMS.
    RESULTS The total number of blood vessels in the cortex on Day 14 after EMS was significantly larger in the VEGF group and the VEGF+apelin group than in the LacZ group (p &lt; 0.05, respectively). Larger vessels appeared in the VEGF+apelin group than in the other groups (p &lt; 0.05, respectively). Apelin protein on Day 7 after EMS was not detected in the cortex for any of the groups. In the attached muscle, apelin protein was detected only in the apelin group and the VEGF+apelin group. Immunofluorescent analysis revealed that apelin and its receptor, APJ, were expressed on endothelial cells (ECs) 7 days after the CCAO.
    CONCLUSIONS Combined gene therapy (VEGF plus apelin) during EMS in a chronic cerebral hypoperfusion model can enhance angiogenesis in rats. This treatment has the potential to be a feasible option in a clinical setting for patients with moyamoya disease.

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  • Efficacy of Fiber Tractography in the Stereotactic Surgery of the Thalamus for Patients with Essential Tremor.

    Susumu Sasada, Takashi Agari, Tatsuya Sasaki, Akihiko Kondo, Aiko Shinko, Takaaki Wakamori, Mihoko Okazaki, Ittetsu Kin, Ken Kuwahara, Masahiro Kameda, Takao Yasuhara, Isao Date

    Neurologia medico-chirurgica   57 ( 8 )   392 - 401   2017年8月

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    記述言語:英語   出版者・発行元:JAPAN NEUROSURGICAL SOC  

    Several targets and targeting methods are utilized in stereotactic surgery to achieve tremor suppression for patients with intractable tremor. Recent developments in magnetic resonance imaging, including diffusion tensor imaging, have enabled the setting of appropriate targets in stereotactic surgery. In this retrospective study, the optimal target to suppress tremors in stereotactic surgery was explored using diffusion tensor image-based fiber tractography. Four tracts were focused on in this study, namely: the cerebello-thalamo-premotor cortical fiber tract, cerebello-thalamo-primary motor cortical fiber tract, spino-thalamo-somatosensory cortical fiber tract, and pyramidal tract. In 10 patients with essential tremor, we evaluated the thalamotomy lesions and active contacts of the lead in thalamic stimulation by diffusion tensor image-based fiber tractography to reveal which part of the cerebral cortex is most affected by stereotactic surgery. Tremor suppression and adverse events were also evaluated in the patients involved in this study. Consequently, the good tremor suppression was achieved in all patients. There had been no permanent adverse events 3 months after surgery. Twelve lesions in thalamotomy patients or active contacts of the lead in thalamic stimulation patients were on the cerebello-thalamo-premotor cortical fiber tract (12/14 lesions or active contacts: 86%). In conclusion, the cerebello-thalamo-premotor cortical fiber tract may be an optimal target for tremor suppression. Diffusion tensor image-based fiber tractography may enable us to both determine the optimal target to achieve strong tremor suppression and to reduce the number of adverse events by keeping lesions or electrodes away from important fiber tracts, such as the pyramidal tract and spinothalamic fibers.

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  • PIK3R1Met326Ile germline mutation correlates with cysteine-rich protein 61 expression and poor prognosis in glioblastoma. 国際誌

    Yoshihiro Otani, Joji Ishida, Kazuhiko Kurozumi, Tetsuo Oka, Toshihiko Shimizu, Yusuke Tomita, Yasuhiko Hattori, Atsuhito Uneda, Yuji Matsumoto, Hiroyuki Michiue, Shuta Tomida, Takehiro Matsubara, Tomotsugu Ichikawa, Isao Date

    Scientific reports   7 ( 1 )   7391 - 7391   2017年8月

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    記述言語:英語   出版者・発行元:NATURE PUBLISHING GROUP  

    Despite therapeutic advances, glioblastoma represents a lethal brain tumor. Recently, research to identify prognostic markers for glioblastoma has intensified. Our previous study demonstrated that median progression-free survival (PFS) and overall survival (OS) of patients with high cysteine-rich protein 61 (CCN1) expression was significantly shorter than that of patients with low CCN1 expression. To understand the molecular mechanisms that regulate CCN1 expression, we examined 147 tumour samples from 80 patients with glioblastoma and 67 patients with lower grade glioma. Next-generation and Sanger sequencing showed that PIK3R1Met326Ile was more frequent in the CCN1 high expression group (10/37 cases, 27.0%) than the CCN1 low expression group (3/38 cases, 7.9%) in glioblastoma. This mutation was also detected in corresponding blood samples. In multivariate analysis, high CCN1 expression and PIK3R1Met326Ile in glioblastoma patients were prognostic factors for OS [HR = 2.488 (1.298-4.769), p = 0.006] and [HR = 2.089 (1.020-4.277), p = 0.0439], respectively. Thus, the PIK3R1Met326Ile germline appears to be correlated with CCN1 expression and poor prognosis in glioblastoma.

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  • Mesenchymal Stem Cell Therapy for Ischemic Stroke.

    Atsuhiko Toyoshima, Takao Yasuhara, Isao Date

    Acta medica Okayama   71 ( 4 )   263 - 268   2017年8月

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    記述言語:英語   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    To date, many animal studies have indicated the neuroprotective effects of mesenchymal stem cell (MSC) transplantation in ischemic stroke. Several clinical studies have also revealed the safety, feasibility, and neuroprotective effects in ischemic stroke patients. In this review, we present the main approaches of MSC transplantation in ischemic stroke, the mechanisms of MSC therapy, and the current clinical studies on MSC transplantation in ischemic stroke patients. We also explore the safety of MSC transplantation and conclude that MSC therapy will play an important role in the future treatment of ischemic stroke. The optimal timing, approach, and cell dose in the transplantation are important issues for successful clinical application.

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  • [Preoperative Embolization for Solid Cerebellar Hemangioblastoma on the Day of Surgery:Two Case Reports].

    Ken Kuwahara, Tomotsugu Ichikawa, Jun Haruma, Tomohito Hishikawa, Masafumi Hiramatsu, Kenji Sugiu, Isao Date

    No shinkei geka. Neurological surgery   45 ( 7 )   615 - 622   2017年7月

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    記述言語:日本語  

    Surgical resection of solid cerebellar hemangioblastomas can be challenging because of the profuse blood supply and tight space. We report two cases of solid cerebellar hemangioblastomas treated via surgical resection with the aid of preoperative endovascular embolization on the day of surgery. Case 1: A 36-year-old woman presented with a two-month history of headache and vomiting. Magnetic resonance imaging(MRI)revealed a right cerebellar solid mass, mild hydrocephalus, and apparent peritumoral edema. Angiogram showed a highly vascularized mass, three feeding arteries from the superior cerebellar artery(SCA), and a dilated vein draining into the confluence. We performed preoperative embolization of the three feeders with 15% n-butyl-2-cyanoacrylate(NBCA). Final angiogram showed an absence of tumor staining. Tumor resection was performed on the same day, and gross total resection was achieved with no complications. Case 2: A 36-year-old man presented with a four-month history of headache and numbness in the left upper extremity. MRI revealed a right cerebellar solid mass with peritumoral edema. Angiogram showed a highly vascularized mass with two feeding arteries from the right SCA, one from the left posterior inferior cerebellar artery(PICA), and a dilated vein draining into the confluence. Preoperative embolization was performed with 15% NBCA, and complete devascularization was achieved. Tumor resection was performed on the same day, and gross total resection was achieved with no complications. In conclusion, preoperative embolization with NBCA on the day of surgery is a safe and effective adjunctive treatment for solid cerebellar hemangioblastoma.

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  • De novo vertebral artery dissecting aneurysm after internal trapping of the contralateral vertebral artery. 国際誌

    Naoya Kidani, Kenji Sugiu, Tomohito Hishikawa, Masafumi Hiramatsu, Jun Haruma, Shingo Nishihiro, Yu Takahashi, Isao Date

    Acta neurochirurgica   159 ( 7 )   1329 - 1333   2017年7月

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    記述言語:英語   出版者・発行元:SPRINGER WIEN  

    We present the case of a de novo vertebral artery dissecting aneurysm (VADA) after endovascular trapping of a ruptured VADA on the contralateral side. The first ruptured VADA involved the posterior inferior cerebellar artery, which was successfully treated by endovascular internal trapping using a stent. A follow-up study at 3 months revealed a de novo VADA on the contralateral side. The second VADA was successfully embolized using coils while normal arterial flow in the vertebral artery was preserved using a stent. Increased hemodynamic stress may cause the development of a de novo VADA on the contralateral side.

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  • Hippocampal neurogenesis of Wistar Kyoto rats is congenitally impaired and correlated with stress resistance. 国際誌

    Kyohei Kin, Takao Yasuhara, Masahiro Kameda, Takashi Agari, Tatsuya Sasaki, Jun Morimoto, Mihoko Okazaki, Michiari Umakoshi, Ken Kuwahara, Ittetsu Kin, Naoki Tajiri, Isao Date

    Behavioural brain research   329   148 - 156   2017年6月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    The hippocampus is thought to be an important region for depression. However, the relationship between hippocampal neurogenesis and depression is still controversial. Wistar Kyoto (WKY) rats are frequently used as a depression model. WKY rats are known to show physiologically abnormal features, and these features resemble abnormalities seen in depressed patients. However, the neurogenesis of WKY rats is still unknown. In this study, we first evaluated the neurogenesis of WKY rats and compared it to that of Wistar (WIS) rats. No strain effect was observed in the number of cells positive for 5-bromo-2'-deoxyuridine (BrdU) and BrdU/Doublecortin (Dcx) in the subventricular zone (SVZ). However, the number of BrdU- and BrdU/Dcx-positive cells in the dentate gyrus (DG) of the hippocampus was significantly lower in WKY rats than in WIS rats. Next, we evaluated the correlation between neurogenesis and behavior tests. Behavior tests did not affect neurogenesis in either strain. Hippocampal neurogenesis correlated negatively with the results of a forced swim test (FST) on day 2 in each strain. That is, rats with a lower level of native neurogenesis in the DG showed a higher level of learned helplessness induced by the inescapable stress of the FST on day 1. Our findings indicate that hippocampal neurogenesis in WKY rats is congenitally impaired in contrast to that in WIS rats. Native cell proliferation and neurogenesis in the DG are correlated with stress resistance. These findings may be useful for developing new targets for depression treatment.

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  • Unruptured Cerebral Aneurysms in Elderly Patients.

    Tomohito Hishikawa, Isao Date

    Neurologia medico-chirurgica   57 ( 6 )   247 - 252   2017年6月

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    記述言語:英語   出版者・発行元:JAPAN NEUROSURGICAL SOC  

    The prevalence of unruptured cerebral aneurysms (UCAs) in elderly patients is increasing in our aging population. UCA management in elderly patients has some difficulties, such as reduced life expectancy, increased comorbidities and treatment risks, and poor prognosis in case of rupture. In this review article, we summarize the most recent findings on the natural history, therapeutic options and treatment results for UCAs exclusively in elderly patients, and describe possible medical treatments for patients with UCAs.

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  • Complex observation of scalp fast (40-150 Hz) oscillations in West syndrome and related disorders with structural brain pathology. 国際誌

    Katsuhiro Kobayashi, Fumika Endoh, Takashi Agari, Tomoyuki Akiyama, Mari Akiyama, Yumiko Hayashi, Takashi Shibata, Yoshiyuki Hanaoka, Makio Oka, Harumi Yoshinaga, Isao Date

    Epilepsia open   2 ( 2 )   260 - 266   2017年6月

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    記述言語:英語  

    We investigated the relationship between the scalp distribution of fast (40-150 Hz) oscillations (FOs) and epileptogenic lesions in West syndrome (WS) and related disorders. Subjects were 9 pediatric patients with surgically confirmed structural epileptogenic pathology (age at initial electroencephalogram [EEG] recording: mean 7.1 months, range 1-22 months). The diagnosis was WS in 7 patients, Ohtahara syndrome in 1, and a transitional state from Ohtahara syndrome to WS in the other. In the scalp EEG data of these patients, we conservatively detected FOs, and then examined the distribution of FOs. In five patients, the scalp distribution of FOs was consistent and concordant with the lateralization of cerebral pathology. In another patient, FOs were consistently dominant over the healthy cerebral hemisphere, and the EEG was relatively low in amplitude over the pathological atrophic hemisphere. In the remaining 3 patients, the dominance of FOs was inconsistent and, in 2 of these patients, the epileptogenic hemisphere was reduced in volume, which may result from atrophy or hypoplasia. The correspondence between the scalp distribution of FOs and the epileptogenic lesion should be studied, taking the type of lesion into account. The factors affecting scalp FOs remain to be elucidated.

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  • Significance of High-frequency Electrical Brain Activity.

    Katsuhiro Kobayashi, Tomoyuki Akiyama, Takashi Agari, Tatsuya Sasaki, Takashi Shibata, Yoshiyuki Hanaoka, Mari Akiyama, Fumika Endoh, Makio Oka, Isao Date

    Acta medica Okayama   71 ( 3 )   191 - 200   2017年6月

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    記述言語:英語   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    Electroencephalogram (EEG) data include broadband electrical brain activity ranging from infra-slow bands (< 0.1 Hz) to traditional frequency bands (e.g., the approx. 10 Hz alpha rhythm) to high-frequency bands of up to 500 Hz. High-frequency oscillations (HFOs) including ripple and fast ripple oscillations (80-200 Hz and>200 / 250 Hz, respectively) are particularly of note due to their very close relationship to epileptogenicity, with the possibility that they could function as a surrogate biomarker of epileptogenicity. In contrast, physiological high-frequency activity plays an important role in higher brain functions, and the differentiation between pathological / epileptic and physiological HFOs is a critical issue, especially in epilepsy surgery. HFOs were initially recorded with intracranial electrodes in patients with intractable epilepsy as part of a long-term invasive seizure monitoring study. However, fast oscillations (FOs) in the ripple and gamma bands (40-80 Hz) are now noninvasively detected by scalp EEG and magnetoencephalography, and thus the scope of studies on HFOs /FOs is rapidly expanding.

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  • Unruptured Cerebral Aneurysms in Elderly Patients

    Tomohito HisHikawa, Isao Date

    NEUROLOGIA MEDICO-CHIRURGICA   57 ( 6 )   247 - 252   2017年6月

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    記述言語:英語   掲載種別:書評論文,書評,文献紹介等   出版者・発行元:JAPAN NEUROSURGICAL SOC  

    The prevalence of unruptured cerebral aneurysms (UCAs) in elderly patients is increasing in our aging population. UCA management in elderly patients has some difficulties, such as reduced life expectancy, increased comorbidities and treatment risks, and poor prognosis in case of rupture. In this review article, we summarize the most recent findings on the natural history, therapeutic options and treatment results for UCAs exclusively in elderly patients, and describe possible medical treatments for patients with UCAs.

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  • Pregnancy and delivery after myelomeningocele repair, ventriculoperitoneal shunt implantation, and augmentation cystoplasty. 国際誌

    Masahiro Kameda, Etsuko Takahara, Motomu Kobayashi, Katsumi Sasaki, Ryuta Morihara, Isao Date

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery   33 ( 6 )   1015 - 1017   2017年6月

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    記述言語:英語   出版者・発行元:SPRINGER  

    INTRODUCTION: Management of pregnancy and delivery of a patient with a history of myelomeningocele requires a multidisciplinary team approach. CASE REPORT: We report a case of pregnancy and delivery by a patient who had a history of myelomeningocele surgical repair, ventriculoperitoneal (VP) shunt, and bladder augmentation enterocystoplasty. Regarding types of delivery style, anesthesiologists recommended a Cesarean section under general anesthesia. However, urologists recommended a vaginal delivery because they were concerned that she would require a nephrostomy because of severe adhesion between her uterus and the neobladder if she had a Cesarean section. DISCUSSION: In a pregnant myelomeningocele patient with a VP shunt, neurosurgeons are expected to manage the VP shunt during pregnancy and delivery. The possible types of delivery style and the best options based on the neurological deficit should be discussed together with a medical team.

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  • Cost-effectiveness analysis of shunt surgery for idiopathic normal pressure hydrocephalus based on the SINPHONI and SINPHONI-2 trials. 国際誌

    Masahiro Kameda, Shigeki Yamada, Masamichi Atsuchi, Teruo Kimura, Hiroaki Kazui, Masakazu Miyajima, Etsuro Mori, Masatsune Ishikawa, Isao Date

    Acta neurochirurgica   159 ( 6 )   995 - 1003   2017年6月

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    記述言語:英語   出版者・発行元:SPRINGER WIEN  

    BACKGROUND: We showed that ventriculoperitoneal (VP) shunt and lumboperitoneal (LP) shunt surgeries are beneficial for patients with idiopathic normal pressure hydrocephalus (iNPH) in the Study of Idiopathic Normal Pressure Hydrocephalus on Neurological Improvement (SINPHONI; a multicenter prospective cohort study) and in SINPHONI-2 (a multicenter randomized trial). Although therapeutic efficacy is important, cost-effectiveness analysis is equally valuable. METHODS: Using both a set of assumptions and using the data from SINPHONI and SINPHONI-2, we estimated the total cost of treatment for iNPH, which consists of medical expenses (e.g., operation fees) and costs to the long-term care insurance system (LCIS) in Japan. Regarding the natural course of iNPH patients, 10% or 20% of patients on each modified Rankin Scale (mRS) show aggravation (aggravation rate: 10% or 20%) every 3 months if the patients do not undergo shunt surgery, as described in a previous report. We performed cost-effectiveness analyses for the various scenarios, calculating the quality-adjusted life year (QALY) and the incremental cost-effective ratio (ICER). Then, based on the definition provided by a previous report, we assessed the cost-effectiveness of shunt surgery for iNPH. RESULTS: In the first year after shunt surgery, the ICER of VP shunt varies from 29,934 to 40,742 USD (aggravation rate 10% and 20%, respectively) and the ICER of LP shunt varies from 58,346 to 80,392 USD (aggravation rate 10% and 20%, respectively), which indicates that the shunt surgery for iNPH is a cost-effective treatment. In the 2nd postoperative year, the cost to the LCIS will continue to decrease because of the lasting improvement of the symptoms due to the surgery. The total cost for iNPH patients will show a positive return on investment in as soon as 18 months (VP) and 21 months (LP), indicating that shunt surgery for iNPH is a cost-effective treatment. CONCLUSIONS: Because the total cost for iNPH patients will show a positive return on investment within 2 years, shunt surgery for iNPH is a cost-effective treatment and therefore recommended. The SINPHONI-2 study was registered with the University Hospital Medical Information Network Clinical Trials registry: UMIN000002730) SINPHONI was registered with ClinicalTrials.gov, no. NCT00221091.

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  • Simultaneous combination of electromagnetic navigation with visual evoked potential in endoscopic transsphenoidal surgery: clinical experience and technical considerations. 国際誌

    Kazuhiko Kurozumi, Masahiro Kameda, Joji Ishida, Isao Date

    Acta neurochirurgica   159 ( 6 )   1043 - 1048   2017年6月

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    記述言語:英語   出版者・発行元:SPRINGER WIEN  

    OBJECTIVE: The combination of electromagnetic navigation with continuous monitoring techniques allows for the best available anatomic and real-time functional intraoperative monitoring. Methodological aspects and technical adaptations for this combination of methods and the results from 19 patients with tumors in the pituitary region are reported. METHODS: We retrospectively identified 19 patients who were treated with transsphenoidal surgery using high-resolution endoscopy (eTSS) at our hospital between June 2015 and June 2016. All patients underwent surgery under electromagnetic navigation with visual evoked potential (VEP) monitoring. The cases were reviewed for information on disease, and the distance between the patient tracker and emitter was measured. RESULTS: In 19 patients, 17 had pituitary adenomas, 1 had a Rathke cleft cyst, and 1 had an arachnoid cyst. The optimal distance between the patient tracker and emitter was 20-25 cm. VEP monitoring could be performed with unaffected recording quality under electromagnetic navigation. Also we were able to perform the registration and eTSS at this distance using both navigation and VEP monitoring. CONCLUSIONS: We performed eTSS for pituitary tumor by simultaneously using electromagnetic navigation and VEP. The optimal distance between the emitter and tracker minimizes VEP monitoring noise and allows accurate electromagnetic navigation.

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  • Congenital Glioblastoma with Distinct Clinical and Molecular Characteristics: Case Reports and a Literature Review. 国際誌

    Masahiro Kameda, Yoshihiro Otani, Tomotsugu Ichikawa, Akira Shimada, Koichi Ichimura, Isao Date

    World neurosurgery   101   817.e5-817.e14   2017年5月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    BACKGROUND: The molecular diagnosis of brain tumors is important in classifying tumors and determining appropriate treatment. Congenital glioblastoma multiforme (GBM) is a rare tumor that occurs in infants, and the prognosis is poor. Approximately 60 patients diagnosed with congenital GBM have been reported. However, few reports have conducted molecular analyses of congenital GBM. CASE DESCRIPTION: We describe 2 congenital GBM patients treated in our hospital, and report results of immunohistochemistry, fluorescent in situ hybridization (FISH), direct sequencing, and methylation analyses. Surgery was performed on both patients at 2 months old, and the cases were diagnosed as glioblastoma. Immunohistochemical staining, FISH, and direct sequencing were positive for glial fibrillary acidic protein and ATRX, partially positive for p53, showed no alteration of isocitrate dehydrogenase 1 R132H, H3F3A, HIST1H3B, and BRAF, and indicated no codeletion of 1p and 19q. Methylation analysis of 1 patient identified copy number aberrations of 4 genes: deletions of CDK6 and CDKN2A/B, and a fusion of MET. One patient received chemotherapy consisting of ranimustine, interferon-beta, carboplatin, and etoposide, whereas the other patient received chemotherapy with the modified Children's Cancer Group study-9921 protocol. Residual tumors in both patients were decreased, and they achieved 18-year- and 9-month progression-free survival, respectively. In addition, we reviewed 65 previously reported congenital GBM patients, and found they have better prognosis than pediatric and adult GBM, and long-term survival can be expected. CONCLUSIONS: Congenital GBM demonstrates clinical and molecular characteristics that are different from those of pediatric or adult GBM.

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  • Intracranial Pressure Monitoring for Pediatric Acute Encephalopathy.

    Nobuyuki Nosaka, Kohei Tsukahara, Emily Knaup, Toshihiko Yabuuchi, Tomonobu Kikkawa, Yosuke Fujii, Masato Yashiro, Takao Yasuhara, Ayumi Okada, Toyomu Ugawa, Atsunori Nakao, Hirokazu Tsukahara, Isao Date

    Acta medica Okayama   71 ( 2 )   179 - 180   2017年4月

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    記述言語:英語   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    Newly published clinical practice guidelines recommend intracranial pressure (ICP) monitoring in critical care for the management of pediatric acute encephalopathy (pAE), but the utility of ICP monitoring for pAE has been poorly studied. We recently performed direct ICP monitoring for two patients. We observed that although the direct ICP monitoring had clinical benefits with less body weight gain and no vasopressor use in both cases, this monitoring technique is still invasive. Future studies should determine the utility of non-invasive ICP monitoring systems in pAE to further improve the quality of intensive-care management.

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  • A case of very long longitudinally extensive transverse myelitis (LETM) with necrotizing Vasculitis. 国際誌

    Kota Sato, Keiichiro Tsunoda, Toru Yamashita, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Toshiyuki Takahashi, Ichiro Nakashima, Takao Yasuhara, Isao Date, Koji Abe

    Journal of the neurological sciences   373   152 - 154   2017年2月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

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  • [Prognostic Impact of Radiation Therapy and Molecular Classification of Infant Atypical Teratoid/Rhabdoid Tumors].

    Yoshihiro Otani, Tomotsugu Ichikawa, Kazuhiko Kurozumi, Takao Yasuhara, Kana Washio, Akira Shimada, Norihisa Katayama, Kuniaki Katsui, Hiroyuki Yanai, Isao Date

    No shinkei geka. Neurological surgery   45 ( 2 )   147 - 154   2017年2月

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    記述言語:日本語  

    Atypical teratoid/rhabdoid tumor(AT/RT)is a rare and lethal childhood cancer. Although radiation therapy in children less than three years of age is generally deferred because of its neural toxicity, recent studies have shown that multimodal therapies, including radiation therapy, are effective in pediatric patients with AT/RT less than three years of age. We treated four infant AT/RT patients and investigated the impact of radiation therapy and genetic classification on the prognosis. The mean age at the time of the operation was 9.3 months and all patients were female. All patients underwent surgical resection. Of the four patients, two received combined irradiation and chemotherapy. Specifically, one patient received conformal craniospinal radiation therapy and the other received craniospinal irradiation with proton beams. Immunohistochemical analyses of tumor specimens revealed that the two patients were positive for ASCL1, a regulator of Notch signaling. Patients who received radiation therapy and exhibited ASCL1-positive tumors had a better prognosis. We conclude that radiation therapy may prolong survival in AT/RT patients who are less than 3 years of age. However, further study is required to evaluate long-term functional outcomes.

    DOI: 10.11477/mf.1436203466

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  • A case of very long longitudinally extensive transverse myelitis (LETM) with necrotizing Vasculitis

    Kota Sato, Keiichiro Tsunoda, Toru Yamashita, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Toshiyuki Takahashi, Ichiro Nakashima, Takao Yasuhara, Isao Date, Koji Abe

    JOURNAL OF THE NEUROLOGICAL SCIENCES   373   152 - 154   2017年2月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    DOI: 10.1016/j.jns.2016.12.040

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  • Disease duration: the key to accurate CSF tap test in iNPH

    S. Yamada, M. Ishikawa, M. Miyajima, M. Atsuchi, T. Kimura, H. Kazui, E. Mori

    ACTA NEUROLOGICA SCANDINAVICA   135 ( 2 )   189 - 196   2017年2月

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    記述言語:英語   出版者・発行元:WILEY-BLACKWELL  

    ObjectivesThe cerebrospinal fluid tap test for idiopathic normal pressure hydrocephalus (iNPH) is one of the good predictors of the shunt treatment, although this test has a low sensitivity. We aimed to identify key parameters that could be used to improve this sensitivity.
    Materials & methodsDuring 2010-2011, we recruited and then followed 93 patients with possible iNPH for 12 months after shunt. Among them, 82 patients were finally enrolled in this study. The modified Rankin Scale, iNPH grading scale, and several quantitative measurements were evaluated at entry, after the tap test, before and after shunt. Area under the receiver-operating characteristic curves (AUCs), sensitivities, and specificities of the tap test for predicting shunt effectiveness were calculated for each measurement. They were additionally assessed after stratification by disease duration since the initial presentation of iNPH symptoms.
    ResultsThe gait disturbance on the iNPH grading scale had the highest accurate scale at the tap test for predicting effectiveness 12 months after shunt: AUC 0.74, sensitivity 56.5%, specificity 91.7%. This AUC increased to 0.76, 0.91 and 0.94 in the subgroup of disease duration &lt;24, &lt;12, and &lt;6 months, respectively. The sensitivity and specificity of the gait disturbance on the iNPH grading scale in the subgroup of &lt;12 months' duration were 92.3% and 90.0%.
    ConclusionsThe shorter period of clinical symptoms, for example, &lt;12 months, made the tap test sufficiently accurate examination for predicting improvement 12 months after shunt surgery. The findings imply that the tap test should be applied to patients being considered for shunt surgery as soon as possible.

    DOI: 10.1111/ane.12580

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  • リハビリテーションが神経保護・神経新生を増幅する.

    安原隆雄, 亀田雅博, 菱川朋人, 伊達 勲

    脳卒中   39 ( 5 )   396 - 399   2017年

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  • Post coiling syndrome might predict recurrence after coil embolization of unruptured cerebral aneurysms.

    Okuma Y, Sugiu K, Hirotsune N, Hishikawa T, Muraoka K, Hiramatsu M, Nishino S, Date I

    Journal of Neuroendovascular Therapy   11 ( 5 )   235 - 239   2017年

  • 片側顔面痙攣MVD術後に痙攣が再出現した症例のマネジメント─3D multifusion imagingによる再発要因の画像評価─.

    佐藤 透, 小野田惠介, 神原啓和, 上利 崇, 亀田雅博, 伊達 勲

    脳神経外科速報   27 ( 6 )   633 - 641   2017年

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  • 血管内治療シミュレーターを用いたシミュレーション教育.

    新治有径, 杉生憲志, 村井 智, 春間 純, 菱川朋人, 平松匡文, 高橋 悠, 木谷尚哉, 西廣真吾, 伊野英男, 伊達 勲

    脳神経外科速報   27 ( 7 )   751 - 754   2017年

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  • 乳児Atypical teratoid/rhabdid tumorに対する放射線治療および分子生物学的分類と予後との関連について.

    大谷理浩, 市川智継, 黒住和彦, 安原隆雄, 鷲尾佳奈, 嶋田 明, 片山敬久, 勝井邦彰, 柳井広之, 伊達 勲

    脳神経外科   45 ( 2 )   147 - 154   2017年

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  • 小児脳神経外科手術における磁場式ナビゲーションの有用性.

    黒住和彦, 亀田雅博, 高橋 悠, 伊達 勲

    小児の脳神経   42 ( 1 )   33 - 39   2017年

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  • 脊髄刺激療法における外科的電極留置術の有用性.

    金 恭平, 上利 崇, 安原隆雄, 佐々木達也, 豊嶋敦彦, 守本 純, 岡崎三保子, 伊達 勲

    脊髄外科   31 ( 1 )   53 - 58   2017年

  • Post coiling syndrome might predict recurrence after coil embolization of unruptured cerebral aneurysms.

    Okuma Y, Sugiu K, Hirotsune N, Hishikawa T, Muraoka K, Hiramatsu M, Nishino S, Date I

    Journal of Neuroendovascular Therapy   11 ( 5 )   235 - 239   2017年

  • 前頭葉に発生し、てんかん原性を示した髄膜腫合併髄膜血管腫症の1例.

    河原明奈, 伏見聡一郎, 板倉淳哉, 藤澤真義, 小林勝弘, 林裕美子, 伊達 勲, 上利 崇, 柳井広之, 松川昭博

    診断病理   34 ( 1 )   46 - 50   2017年

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  • A successfully-treated case of penetrating facial trauma.

    Yumoto T, Iida A, Tsukahara K, Naito H, Terado M, Sato K, Date I, Nakao A

    International Journal of Case Reports and Images   8 ( 2 )   120 - 123   2017年

  • A successfully-treated case of penetrating facial trauma.

    Yumoto T, Iida A, Tsukahara K, Naito H, Terado M, Sato K, Date I, Nakao A

    International Journal of Case Reports and Images   8 ( 2 )   120 - 123   2017年

  • グリオーマ血管新生に対する分子標的薬─血管制御系と疾患─.

    黒住和彦, 伊達 勲

    生体の科学   68 ( 4 )   339 - 343   2017年

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  • 硬膜動静脈瘻─動脈・静脈の疾患(臓器別):脳血管疾患─.

    菱川朋人, 杉生憲志, 伊達 勲

    日本臨床 増刊号 動脈・静脈の疾患 下   75 ( Suppl 5 )   715 - 718   2017年

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  • 急性期脳梗塞の血管内治療最前線.

    杉生憲志, 平松匡文, 菱川朋人, 伊達 勲

    日本内科学会雑誌   106 ( 8 )   1646 - 1651   2017年

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  • パーキンソン病と再生医療.

    安原隆雄, 田尻直輝, 伊達 勲

    総合リハビリテーション   45 ( 1 )   21 - 26   2017年

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  • 脳血管攣縮に対する薬物療法.

    菱川朋人, 伊達 勲

    脳神経外科   45 ( 3 )   265 - 270   2017年

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  • パーキンソン病に対する脳深部刺激療法─視床下核に対する脳深部電極留置術─.

    上利 崇, 佐々木達也, 伊達 勲

    脳神経外科速報   27 ( 7 )   680 - 688   2017年

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  • 脳虚血、頭部外傷、脳血管攣縮におけるHMGB1の役割.

    大熊 佑, 西堀正洋, 春間 純, 西野繁樹, 伊達 勲

    脳神経外科速報   28 ( 7 )   714 - 720   2017年

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  • 手術当日術全塞栓術が有用であった充実性小脳血管芽腫の2例.

    桑原 研, 市川智継, 春間 純, 菱川朋人, 平松匡文, 杉生憲志, 伊達 勲

    脳神経外科   45 ( 7 )   615 - 622   2017年

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  • 3DDSA-MRI fusion画像を用いた脳血管障害に対する開頭手術術前シミュレーション.

    平松匡文, 杉生憲志, 菱川朋人, 春間 純, 高杉祐二, 西廣真吾, 新治有径, 伊達 勲

    脳卒中の外科   45 ( 4 )   270 - 275   2017年

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    記述言語:日本語   出版者・発行元:(一社)日本脳卒中の外科学会  

    2013年9月〜2015年10月に脳血管障害に対する開頭手術術前に3DDSA-MRI fusion画像を作成した3例を対象に、画像作成法を紹介し、脳血管障害に対する手術の術前シミュレーションとして有用か検討した。fusion画像は10〜15分程度で、全例問題なく作成できた。全例、fusion画像の有用性が認められ、手術戦略や手術アプローチに影響を与えていた。血管位置の最大誤差は平均2.5±0.1mmであったが、実際の術野での脳表上の血管構造物の同定には全例支障がなかった。頭蓋内血管病変に対する3DDSA-MRI fusionを活用することで、脳血管障害に対する術前シミュレーションとして有効と思われた。

    DOI: 10.2335/scs.45.270

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    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J02079&link_issn=&doc_id=20170810180005&doc_link_id=%2Fcp4strok%2F2017%2F004504%2F005%2F0270-0275%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcp4strok%2F2017%2F004504%2F005%2F0270-0275%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • リハビリテーションは神経保護・神経新生に影響を与える.

    安原隆雄, 田尻直輝, 亀田雅博, 大熊 佑, 守本 純, 金 恭平, 馬越通有, 伊達 勲

    神経外傷   40 ( 1 )   63 - 65   2017年

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  • 非もやもや病小児脳梗塞・脳虚血症例の治療におけるチーム医療の重要性.

    安原隆雄, 菱川朋人, 亀田雅博, 平松匡文, 杉生憲志, 野坂宣之, 塚原紘平, 八代将登, 林裕美子, 伊達 勲

    脳卒中の外科   45 ( 6 )   476 - 482   2017年

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    記述言語:日本語   出版者・発行元:(一社)日本脳卒中の外科学会  

    症例1:9歳女児。左片麻痺で発症し、右内包後脚脳梗塞と診断された。aspirin内服を行い、24ヵ月再発なく外来加療中である。症例2:13歳男児。けいれん発作、意識障害、左片麻痺が生じ、動脈炎として加療開始された。右中大脳動脈領域に脳梗塞を認めたため外減圧術を施行したが、第62病日に頭蓋骨形成術を施行後に意識障害が生じ、けいれん重積状態となった。barbitalを用いた2週間にわたる鎮静・呼吸循環管理にて徐々に改善したが、左不全麻痺の悪化、右不全麻痺を生じた。17ヵ月経過現在、両杖をついた歩行訓練を行っている。症例3:10ヵ月女児。左不全片麻痺で発症し、3日後に意識障害が生じた。右側の血栓性脳梗塞と考えaspirin内服を開始したが、脳梗塞の再発、左側に新規の脳梗塞を来たした。warfarinとaspirinの内科加療を開始し、16ヵ月再発なく経過している。症例4:2歳女児。Klippel-Trenaunay症候群として経過観察されていた。繰り返す左片麻痺とけいれん発作が生じ、右内頸動脈の閉塞ないし狭窄に伴う脳虚血と診断し、aspirin内服加療を開始した。16ヵ月間再発なく経過している。

    DOI: 10.2335/scs.45.476

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  • Translating regenerative medicine techniques for the treatment of epilepsy.

    Yasuhara T, Date I, Liska GL, Kaneko Y, Vale FL

    Brain Circulation   3 ( 3 )   156 - 162   2017年

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  • Surgery in the Standing Position by a Surgeon with Achilles Tendon Rupture.

    Takao Yasuhara, Ken Kuwahara, Susumu Sasada, Atsuhiko Toyoshima, Jun Morimoto, Kyohei Kin, Hiroaki Manabe, Yasuyuki Miyoshi, Akira Kusumegi, Yuichi Takahashi, Kiyoshi Ito, Isao Date

    Acta medica Okayama   70 ( 6 )   493 - 496   2016年12月

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    記述言語:英語   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    Unexpected injuries can have a profound effect on a surgeon's performance and thus on patients and surgical departments. Here we describe a technique for performing surgery in the standing position, as done by a surgeon with an Achilles tendon rupture. During his prescribed 45-day non-weight-bearing period for the left ankle after surgery for an Achilles tendon rupture, the surgeon was able to participate in 15 surgeries as an operator or assistant, due to his use of a combination of injured-leg genuflection on a stool and a 'Surgical Body Support' device. Similarly injured surgeons may benefit from such support.

    DOI: 10.18926/AMO/54813

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  • Anti-high mobility group box-1 (HMGB1) antibody attenuates delayed cerebral vasospasm and brain injury after subarachnoid hemorrhage in rats. 国際誌

    Jun Haruma, Kiyoshi Teshigawara, Tomohito Hishikawa, Dengli Wang, Keyue Liu, Hidenori Wake, Shuji Mori, Hideo Kohka Takahashi, Kenji Sugiu, Isao Date, Masahiro Nishibori

    Scientific reports   6   37755 - 37755   2016年11月

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    記述言語:英語   出版者・発行元:NATURE PUBLISHING GROUP  

    Although delayed cerebral vasospasm (DCV) following subarachnoid hemorrhage (SAH) is closely related to the progression of brain damage, little is known about the molecular mechanism underlying its development. High mobility group box-1 (HMGB1) plays an important role as an initial inflammatory mediator in SAH. In this study, an SAH rat model was employed to evaluate the effects of anti-HMGB1 monoclonal antibody (mAb) on DCV after SAH. A vasoconstriction of the basilar artery (BA) associated with a reduction of nuclear HMGB1 and its translocation in vascular smooth muscle cells were observed in SAH rats, and anti-HMGB1 mAb administration significantly suppressed these effects. Up-regulations of inflammation-related molecules and vasoconstriction-mediating receptors in the BA of SAH rats were inhibited by anti-HMGB1 mAb treatment. Anti-HMGB1 mAb attenuated the enhanced vasocontractile response to thrombin of the isolated BA from SAH rats and prevented activation of cerebrocortical microglia. Moreover, locomotor activity and weight loss recovery were also enhanced by anti-HMGB1 mAb administration. The vasocontractile response of the BA under SAH may be induced by events that are downstream of responses to HMGB1-induced inflammation and inhibited by anti-HMGB1 mAb. Anti-HMGB1 mAb treatment may provide a novel therapeutic strategy for DCV and early brain injury after SAH.

    DOI: 10.1038/srep37755

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  • Working Conditions and Lifestyle of Female Surgeons Affiliated to the Japan Neurosurgical Society: Findings of Individual and Institutional Surveys.

    Takamitsu Fujimaki, Soichiro Shibui, Yoko Kato, Akira Matsumura, Mami Yamasaki, Isao Date, Kazuhiro Hongo, Satoshi Kuroda, Mitsunori Matsumae, Naoyuki Nakao, Kaori Sakurada, Shoko Shimokawa, Takamasa Kayama

    Neurologia medico-chirurgica   56 ( 11 )   704 - 708   2016年11月

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    記述言語:英語   出版者・発行元:JAPAN NEUROSURGICAL SOC  

    To investigate the working conditions of female neurosurgeons in Japan, two surveys were conducted by The Japan Neurosurgical Society: one involving female neurosurgeons themselves and the other involving the chiefs of neurosurgical departments. The responses were received from 224 (43.8%) female neurosurgeons and 496 (61.2%) departmental chiefs. About half (50.2%) of the female neurosurgeons were married and 39.2% had children (average number of children, 1.27). Their work was full-time in 80.6% of cases; on average, they worked 51.9 h per week, had night duty 2.8 times per month, and had 5.7 days off per month. Many of them stated that they were satisfied with their job status, but about half of them reported difficulty in maintaining a correct work-life balance. Among the institutions surveyed, 29% had female neurosurgeons. The survey of departmental chiefs revealed that the proxies for maternity leave were not available at most institutions, and that there was only limited availability of night child care (41%) or sick child care (39%); female neurosurgeons did not appear to be well-informed of these support systems. These findings suggest that apart from systematic approaches already in place, female neurosurgeons would prefer to have more understanding from their peers and chiefs.

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  • Anti-high mobility group box-1 (HMGB1) antibody attenuates delayed cerebral vasospasm and brain injury after subarachnoid hemorrhage in rats

    Jun Haruma, Kiyoshi Teshigawara, Tomohito Hishikawa, Dengli Wang, Keyue Liu, Hidenori Wake, Shuji Mori, Hideo Kohka Takahashi, Kenji Sugiu, Isao Date, Masahiro Nishibori

    SCIENTIFIC REPORTS   6   doi: 10.1038/srep37755   2016年11月

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    記述言語:英語   出版者・発行元:NATURE PUBLISHING GROUP  

    Although delayed cerebral vasospasm (DCV) following subarachnoid hemorrhage (SAH) is closely related to the progression of brain damage, little is known about the molecular mechanism underlying its development. High mobility group box-1 (HMGB1) plays an important role as an initial inflammatory mediator in SAH. In this study, an SAH rat model was employed to evaluate the effects of anti-HMGB1 monoclonal antibody (mAb) on DCV after SAH. A vasoconstriction of the basilar artery (BA) associated with a reduction of nuclear HMGB1 and its translocation in vascular smooth muscle cells were observed in SAH rats, and anti-HMGB1 mAb administration significantly suppressed these effects. Upregulations of inflammation-related molecules and vasoconstriction-mediating receptors in the BA of SAH rats were inhibited by anti-HMGB1 mAb treatment. Anti-HMGB1 mAb attenuated the enhanced vasocontractile response to thrombin of the isolated BA from SAH rats and prevented activation of cerebrocortical microglia. Moreover, locomotor activity and weight loss recovery were also enhanced by anti-HMGB1 mAb administration. The vasocontractile response of the BA under SAH may be induced by events that are downstream of responses to HMGB1-induced inflammation and inhibited by anti-HMGB1 mAb. Anti-HMGB1 mAb treatment may provide a novel therapeutic strategy for DCV and early brain injury after SAH.

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  • Quantitative analysis of brain edema in patients with malignant glioma treated with BCNU wafers. 国際誌

    Satoshi Murai, Tomotsugu Ichikawa, Kazuhiko Kurozumi, Yosuke Shimazu, Tetsuo Oka, Yoshihiro Otani, Toshihiko Shimizu, Isao Date

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia   33   148 - 153   2016年11月

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    記述言語:英語   出版者・発行元:ELSEVIER SCI LTD  

    BCNU wafers are a form of interstitial chemotherapy that is expected to improve the survival of patients with malignant glioma. However, their adverse events, especially brain edema, sometimes cause significant clinical symptoms. In this study, we performed a volumetric analysis of brain edema after the implantation of BCNU wafers and reported on the clinical course, and exacerbation factors of brain edema. Twelve patients who underwent surgical resection of supratentorial malignant glioma and BCNU wafer implantation, were enrolled. Radiographic quantitative analysis was conducted and compared with a historical control. The volume change in brain edema was divided into three groups and correlation with clinical symptoms was then evaluated. Compared with the control group, the brain edema in the BCNU wafer implantation group was significantly prolonged after surgery. Radiographic volumetric analysis revealed an increase of more than 25% at any time after surgery in four patients (33%) and a reduction of less than 25%, 1month after surgery in three patients (25%). Grade 3 clinical deterioration related to brain edema occurred in two patients and Grade 2 in one patient. Univariate analysis revealed that the radiographic deterioration of brain edema had no correlation with age, sex, diagnosis, tumor grade, preoperative volume of brain edema and tumor, residual tumor volume, or number of BCNU wafers. Radiographic quantitative analysis of brain edema indicated that BCNU wafer implantation may induce the prolongation and enlargement of brain edema with or without neurological deterioration. Brain edema may be controlled by intensive perioperative treatment with diuretics and corticosteroids.

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  • A Segmental Copy Number Loss of the SFMBT1 Gene Is a Genetic Risk for Shunt-Responsive, Idiopathic Normal Pressure Hydrocephalus (iNPH): A Case-Control Study

    Hidenori Sato, Yoshimi Takahashi, Luna Kimihira, Chifumi Iseki, Hajime Kato, Yuya Suzuki, Ryosuke Igari, Hiroyasu Sato, Shingo Koyama, Shigeki Arawaka, Toru Kawanami, Masakazu Miyajima, Naoyuki Samejima, Shinya Sato, Masahiro Kameda, Shinya Yamada, Daisuke Kita, Mitsunobu Kaijima, Isao Date, Yukihiko Sonoda, Takamasa Kayama, Nobumasa Kuwana, Hajime Aral, Takeo Kato

    PLOS ONE   11 ( 11 )   2016年11月

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    記述言語:英語   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    Little is known about genetic risk factors for idiopathic normal pressure hydrocephalus (iNPH). We examined whether a copy number loss in intron 2 of the SFMBT1 gene could be a genetic risk for shunt-responsive, definite iNPH. Quantitative and digital PCR analyses revealed that 26.0% of shunt-responsive definite iNPH patients (n = 50) had such a genetic change, as compared with 4.2% of the healthy elderly (n = 191) (OR = 7.94, 95% CI: 2.82-23.79, p = 1.8 x 10(-5)) and 6.3% of patients with Parkinson's disease (n = 32) (OR = 5.18, 95% CI: 1.1-50.8, p = 0.038). The present study demonstrates that a copy number loss within intron 2 of the SFMBT1 gene may be a genetic risk factor for shunt-responsive definite iNPH.

    DOI: 10.1371/journal.pone.0166615

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  • Cerebral Infarction Arising from Takotsubo Cardiomyopathy: Case Report and Literature Review.

    Yoshihiro Otani, Koji Tokunaga, Satoshi Kawauchi, Satoshi Inoue, Kyoichi Watanabe, Hideki Kiriyama, Kosuke Sakane, Kiyoaki Maekawa, Isao Date, Kengo Matsumoto

    NMC case report journal   3 ( 4 )   119 - 123   2016年10月

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    記述言語:英語  

    Although most patients with takotsubo cardiomyopathy have a favorable outcome, complications are not uncommon. Recent studies have reported an increase in incidence of cardioembolic complications; however, the association between takotsubo cardiomyopathy and stroke, in particular thromboembolic cerebral infarction, remains unclear. We reported a 44-year-old woman who had a cerebral infarction resulting from takotsubo cardiomyopathy. She had felt chest discomfort a few days prior to infarction, and later developed left hemiparesis. Head magnetic resonance imaging (MRI) revealed acute infarction in the right insular cortex and occlusion of the right middle cerebral artery at the M2 segment. Echocardiogram revealed a takotsubo-like shape in the motion of the left ventricular wall, and coronary angiography showed neither coronary stenosis nor occlusion. Cerebral infarction resulting from takotsubo cardiomyopathy was diagnosed and treatment with anticoagulant was started. MRI on the eighth day after hospitalization showed recanalization of the right middle cerebral artery and no new ischemic lesions. The findings of the 19 previously published cases who had cerebral infarction resulting from takotsubo cardiomyopathy were also reviewed and showed the median interval between takotsubo cardiomyopathy and cerebral infarction was approximately 1 week and cardiac thrombus was detected in 9 of 19 patients. We revealed that thromboembolic events occurred later than other complications of takotsubo cardiomyopathy and longer observation might be required due to possible cardiogenic cerebral infarction. Anticoagulant therapy is recommended for patients with takotsubo cardiomyopathy with cardiac thrombus or a large area of akinetic left ventricle.

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  • Perioperative Management Center (PERIO) for Neurosurgical Patients.

    Takao Yasuhara, Tomohito Hishikawa, Takashi Agari, Kazuhiko Kurozumi, Tomotsugu Ichikawa, Masahiro Kameda, Aiko Shinko, Joji Ishida, Masafumi Hiramatsu, Motomu Kobayashi, Yoshikazu Matsuoka, Toshihiro Sasaki, Yoshihiko Soga, Reiko Yamanaka, Takako Ashiwa, Akemi Arioka, Yasuko Hashimoto, Ayasa Misaki, Yuriko Ishihara, Machiko Sato, Hiroshi Morimatsu, Isao Date

    Neurologia medico-chirurgica   56 ( 9 )   574 - 9   2016年9月

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    記述言語:英語   出版者・発行元:JAPAN NEUROSURGICAL SOC  

    Perioperative management is critical for positive neurosurgical outcomes. In order to maintain safe and authentic perioperative management, a perioperative management center (PERIO) was introduced to patients of our Neurosurgery Department beginning in June 2014. PERIO involves a multidisciplinary team consisting of anesthesiologists, dentists/dental hygienists/technicians, nurses, physical therapists, pharmacists, and nutritionists. After neurosurgeons decide on the course of surgery, a preoperative evaluation consisting of blood sampling, electrocardiogram, chest X-ray, and lung function test was performed. The patients then visited the PERIO clinic 7-14 days before surgery. One or two days before surgery, the patients without particular issues enter the hospital and receive a mouth cleaning one day before surgery. After surgery, postoperative support involving eating/swallowing evaluation, rehabilitation, and pain control is provided. The differences in duration from admission to surgery, cancellation of surgery, and postoperative complications between PERIO and non-PERIO groups were examined. Eighty-five patients were enrolled in the PERIO group and 131 patients in the non-PERIO group. The duration from admission to surgery was significantly decreased in the PERIO group (3.6 ± 0.3 days), compared to that in the non-PERIO group (4.7 ± 0.2 days). There was one cancelled surgery in the PERIO group and six in the non-PERIO group. Postoperative complications and the overall hospital stay did not differ between the two groups. The PERIO system decreased the duration from admission to surgery, and it is useful in providing high-quality medical service, although the system should be improved so as not to increase the burden on medical staff.

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  • A super gene expression system enhances the anti-glioma effects of adenovirus-mediated REIC/Dkk-3 gene therapy. 国際誌

    Tetsuo Oka, Kazuhiko Kurozumi, Yosuke Shimazu, Tomotsugu Ichikawa, Joji Ishida, Yoshihiro Otani, Toshihiko Shimizu, Yusuke Tomita, Masakiyo Sakaguchi, Masami Watanabe, Yasutomo Nasu, Hiromi Kumon, Isao Date

    Scientific reports   6   33319 - 33319   2016年9月

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    記述言語:英語   出版者・発行元:NATURE PUBLISHING GROUP  

    Reduced expression in immortalized cells/Dickkopf-3 (REIC/Dkk-3) is a tumor suppressor and therapeutic gene in many human cancers. Recently, an adenovirus REIC vector with the super gene expression system (Ad-SGE-REIC) was developed to increase REIC/Dkk-3 expression and enhance therapeutic effects compared with the conventional adenoviral vector (Ad-CAG-REIC). In this study, we investigated the in vitro and in vivo effects of Ad-SGE-REIC on malignant glioma. In U87ΔEGFR and GL261 glioma cells, western blotting confirmed that robust upregulation of REIC/Dkk-3 expression occurred in Ad-SGE-REIC-transduced cells, most notably after transduction at a multiplicity of infection of 10. Cytotoxicity assays showed that Ad-SGE-REIC resulted in a time-dependent and significant reduction in the number of malignant glioma cells attaching to the bottom of culture wells. Xenograft and syngeneic mouse intracranial glioma models treated with Ad-SGE-REIC had significantly longer survival than those treated with the control vector Ad-LacZ or with Ad-CAG-REIC. This study demonstrated the anti-glioma effect of Ad-SGE-REIC, which may represent a promising strategy for the treatment of malignant glioma.

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  • Moyamoya Disease: A Review of Clinical Research

    Tomohito Hishikawa, Kenji Sugiu, Isao Date

    ACTA MEDICA OKAYAMA   70 ( 4 )   229 - 236   2016年8月

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    記述言語:英語   掲載種別:書評論文,書評,文献紹介等   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    About 5 decades have passed since the concept of moyamoya disease (MMD) was established in Japan. In that time, many clinical MMD studies have been performed from several different points of view, such as epidemiology, pathophysiology, surgical procedures, and prognosis. In addition, rapid developments in MMD genetic analysis have occurred. In light of all this activity, clinicians must continually update their knowledge of MMD in order to improve the prognosis of MMD patients. In this review article, we summarize the clinical MMD studies and introduce cutting-edge findings regarding MMD.

    DOI: 10.18926/AMO/54497

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  • Moyamoya Disease: A Review of Clinical Research.

    Tomohito Hishikawa, Kenji Sugiu, Isao Date

    Acta medica Okayama   70 ( 4 )   229 - 36   2016年8月

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    記述言語:英語   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    About 5 decades have passed since the concept of moyamoya disease (MMD) was established in Japan. In that time, many clinical MMD studies have been performed from several different points of view, such as epidemiology, pathophysiology, surgical procedures, and prognosis. In addition, rapid developments in MMD genetic analysis have occurred. In light of all this activity, clinicians must continually update their knowledge of MMD in order to improve the prognosis of MMD patients. In this review article, we summarize the clinical MMD studies and introduce cutting-edge findings regarding MMD.

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  • Phenotypic Transition as a Survival Strategy of Glioma.

    Tomotsugu Ichikawa, Yoshihiro Otani, Kazuhiko Kurozumi, Isao Date

    Neurologia medico-chirurgica   56 ( 7 )   387 - 95   2016年7月

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    記述言語:英語   出版者・発行元:JAPAN NEUROSURGICAL SOC  

    Malignant glioma is characterized by rapid proliferation, invasion into surrounding central nervous system tissues, and aberrant vascularization. There is increasing evidence that shows gliomas are more complex than previously thought, as each tumor comprises considerable intratumoral heterogeneity with mixtures of genetically and phenotypically distinct subclones. Heterogeneity within and across tumors is recognized as a critical factor that limits therapeutic progress for malignant glioma. Recent genotyping and expression profiling of gliomas has allowed for the creation of classification schemes that assign tumors to subtypes based on similarity to defined expression signatures. Also, malignant gliomas frequently shift their biological features upon recurrence and progression. The ability of glioma cells to resist adverse conditions such as hypoxia and metabolic stress is necessary for sustained tumor growth and strongly influences tumor behaviors. In general, glioma cells are in one of two phenotypic categories: higher proliferative activity with angiogenesis, or higher migratory activity with attenuated proliferative ability. Further, they switch phenotypic categories depending on the situation. To date, a multidimensional approach has been employed to clarify the mechanisms of phenotypic shift of glioma. Various molecular and signaling pathways are involved in phenotypic shifts of glioma, possibly with crosstalk between them. In this review, we discuss molecular and phenotypic heterogeneity of glioma cells and mechanisms of phenotypic shifts in regard to the glioma proliferation, angiogenesis, and invasion. A better understanding of the molecular mechanisms that underlie phenotypic shifts of glioma may provide new insights into targeted therapeutic strategies.

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  • [A Case of an Adrenocorticotropic Hormone-Producing Pituitary Adenoma Removed via Electromagnetic-Guided Neuroendoscopy].

    Yusuke Tomita, Kazuhiko Kurozumi, Tomohiro Terasaka, Kenichi Inagaki, Fumio Otsuka, Isao Date

    No shinkei geka. Neurological surgery   44 ( 6 )   473 - 9   2016年6月

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    記述言語:日本語  

    The use of navigation systems is safe and reliable for neurological surgery. We performed endoscopic transsphenoidal surgery to totally resect an adrenocorticotropic hormone (ACTH)-producing pituitary adenoma associated with oculomotor nerve palsy. A 70-year-old woman developed right ptosis 4 months before admission. She developed anisocoria 2 months later and was referred to the department of neurology from clinic. Brain magnetic resonance imaging(MRI)showed an intrasellar tumor that partially invaded the right cavernous sinus, and she was then referred to our department. She exhibited a round face ("moon face") and central obesity. Laboratory test results showed a high urinary cortisol level and high serum ACTH level, and neither the serum cortisol nor ACTH level was suppressed by a low-dose dexamethasone test. We performed transsphenoidal surgery using high-dimensional endoscopy under electromagnetic navigation. The tumor invading the cavernous sinus was visualized via endoscopy and confirmed on navigation using a flexible needle probe. Postoperative MRI showed total removal of the tumor, and the serum ACTH level recovered to the normal range. The patient's right oculomotor palsy resolved within 1 week postoperatively. In summary, electromagnetic navigation was useful for total resection of a pituitary tumor invading the cavernous sinus, contributing to normalization of the ACTH level and improvement in neurological symptoms.

    DOI: 10.11477/mf.1436203313

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  • Adhesion molecules and the extracellular matrix as drug targets for glioma.

    Toshihiko Shimizu, Kazuhiko Kurozumi, Joji Ishida, Tomotsugu Ichikawa, Isao Date

    Brain tumor pathology   33 ( 2 )   97 - 106   2016年4月

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    記述言語:英語   出版者・発行元:SPRINGER JAPAN KK  

    The formation of tumor vasculature and cell invasion along white matter tracts have pivotal roles in the development and progression of glioma. A better understanding of the mechanisms of angiogenesis and invasion in glioma will aid the development of novel therapeutic strategies. The processes of angiogenesis and invasion cause the production of an array of adhesion molecules and extracellular matrix (ECM) components. This review focuses on the role of adhesion molecules and the ECM in malignant glioma. The results of clinical trials using drugs targeted against adhesion molecules and the ECM for glioma are also discussed.

    DOI: 10.1007/s10014-016-0261-9

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  • A Case of Unexpected Symptomatic Vasospasm after Clipping Surgery for an Unruptured Intracranial Aneurysm. 国際誌

    Hiroaki Hashimoto, Masahiro Kameda, Takao Yasuhara, Isao Date

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   25 ( 3 )   e25-7 - E27   2016年3月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    Delayed symptomatic vasospasm after clipping surgery for unruptured aneurysm is rarely reported. We report a case of a 62-year-old woman who presented with symptomatic vasospasm 11 days after clipping surgery for an unruptured aneurysm. We could not predict the existence of vasospasm until ischemic symptoms developed. We retrospectively found mild vasospasm in the computed tomography angiogram taken 8 days after the operation. The patient complained of a prolonged unexpected headache 1 week after the operation. We should recognize prolonged unexpected headache as a warning sign of vasospasm.

    DOI: 10.1016/j.jstrokecerebrovasdis.2015.11.029

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  • [A Case of Traumatic Vertebral Arteriovenous Fistula Treated by Internal Trapping of the Vertebral Artery].

    Shingo Nishihiro, Kenji Sugiu, Tomohito Hishikawa, Masafumi Hiramatsu, Jun Haruma, Yukei Shinji, Yuji Takasugi, Isao Date

    No shinkei geka. Neurological surgery   44 ( 2 )   135 - 41   2016年2月

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    記述言語:日本語  

    BACKGROUND: Traumatic vertebral arteriovenous fistula (TVAVF) is an uncommon disease that occurs after traumatic injury. Here we report a case of TVAVF presenting with cervical bruit successfully treated by internal trapping using coils. CASE PRESENTATION: A 66-year-old man was transferred to our hospital after falling into a ditch. Initial CT revealed a C2 fracture into the right transverse foramen, and the patient had been treated with conservative management. A vascular abnormality was suspected because the patient exhibited cervical bruit on admission. CT angiography revealed right TVAVF at the V2 segment of the right vertebral artery (VA) near the C2 fracture. Digital subtraction angiography also revealed right TVAVF between the V2 segment of the right VA and the vertebral venous plexus, draining into the right internal jugular vein and the deep cervical vein as well as the intracranial venous system. The fistula was also opacified by retrograde flow from the contralateral VA through the union, while the flow in the basilar artery was antegrade. The patient was diagnosed with TVAVF with large transection of the right VA, and underwent endovascular treatment with internal trapping of the right VA using coils starting distal to the transection and proceeding in a proximal direction. After treatment, the right VAVF and right VA were completely occluded. The patient achieved clinical symptom resolution with no neurological deficits. CONCLUSION: Endovascular treatment with internal trapping of the VA using coils is safe and effective against TVAVF.

    DOI: 10.11477/mf.1436203245

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  • Hybrid Microscopic-Endoscopic Surgery for Craniopharyngioma in Neurosurgical Suite: Technical Notes

    Tomotsugu Ichikawa, Yoshihiro Otani, Joji Ishida, Kentaro Fujii, Kazuhiko Kurozumi, Shigeki Ono, Isao Date

    WORLD NEUROSURGERY   85   340 - +   2016年1月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    OBJECTIVE: The best chance of curing craniopharyngioma is achieved by microsurgical total resection; however, its location adjacent to critical structures hinders complete resection without neurologic deterioration. Unrecognized residual tumor within microscopic blind spots might result in tumor recurrences. To improve outcomes, new techniques are necessary to visualize tissue within these blind spots. We examined the success of hybrid microscopic-endoscopic neurosurgery for craniopharyngioma in a neurosurgical suite.
    METHODS: Four children with craniopharyngiomas underwent microscopic resection. When the neurosurgeon was confident that most of the visible tumor was removed but was suspicious of residual tumor within the blind spot, he or she used an integrated endoscope-holder system to inspect and remove any residual tumor. Two ceiling monitors were mounted side by side in front of the surgeon to display both microscopic and endoscopic views and to view both monitors simultaneously.
    RESULTS: Surgery was performed in all patients via the frontobasal interhemispheric approach. Residual tumors were observed in the sella (2 patients), on the ventral surface of the chiasm and optic nerve (1 patient), and in the third ventricle (1 patient) and were resected to achieve total resection. Postoperatively, visual function was improved in 2 patients and none exhibited deterioration related to the surgery.
    CONCLUSIONS: Simultaneous microscopic and endoscopic observation with the use of dual monitors in a neurosurgical suite was ergonomically optimal for the surgeon to perform microsurgical procedures and to avoid traumatizing surrounding vessels or neural tissues. Hybrid microscopic-endoscopic neurosurgery may contribute to safe, less-invasive, and maximal resection to achieve better prognosis in children with craniopharyngioma.

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  • Anti-high mobility group box 1 antibody exerts neuroprotection in a rat model of Parkinson's disease

    Tatsuya Sasaki, Keyue Liu, Takashi Agari, Takao Yasuhara, Jun Morimoto, Mihoko Okazaki, Hayato Takeuchi, Atsuhiko Toyoshima, Susumu Sasada, Aiko Shinko, Akihiko Kondo, Masahiro Kameda, Ikuko Miyazaki, Masato Asanuma, Cesario V. Borlongan, Masahiro Nishibori, Isao Date

    EXPERIMENTAL NEUROLOGY   275   220 - 231   2016年1月

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    記述言語:英語   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    The high mobility group box-1 (HMGB1) exists as an architectural nuclear protein in the normal state, but displays an inflammatory cytokine-like activity in the extracellular space under pathological condition. Inflammation in the pathogenesis of Parkinson's disease (PD) has been documented. In this study, we investigated the involvement of HMGB1 in the pathology and the neuroprotective effects of neutralizing anti-HMGB1 monoclonal antibody (mAb) on an animal model of PD. Adult female Sprague-Dawley rats were initially injected with 6-hydroxydopmaine (6-OHDA, 20 mu g/4 mu l) into the right striatum, then anti-HMGB1 mAb (1 mg/kg), or control mAb was intravenously administered immediately, at 6 and 24 h after 6-OHDA injection. The treatment with anti-HMGB1 mAb significantly preserved dopaminergic neurons in substantia nigra pars compacta and dopaminergic terminals inherent in the striatum, and attenuated PD behavioral symptoms compared to the control mAb-treated group. HMGB1 was retained in the nucleus of neurons and astrocytes by inhibiting the proinflammation-induced oxidative stress in the anti-HMGB1 mAb-treated group, whereas HMGB1 translocation was observed in neurons at 1 day and astrocytes at 7 days after 6-OHDA injection in the control mAb-treated group. Anti-HMGB1 mAb inhibited the activation of microglia, disruption of blood-brain-barrier (BBB), and the expression of inflammation cytokines such as IL-1 beta. and IL-6. These results suggested that HMGB1 released from neurons and astrocytes was at least partly involved in the mechanism and pathway of degeneration of dopaminergic neurons induced by 6-0HDA exposure. Intravenous administration of anti-HMGB1 mAb stands as a novel therapy for PD possibly acting through the suppression of neuroinflammation and the attenuation of disruption of BOB associated with the disease. (C) 2015 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.expneurol.2015.11.003

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  • Anti-high mobility group box 1 antibody exerts neuroprotection in a rat model of Parkinson's disease. 国際誌

    Tatsuya Sasaki, Keyue Liu, Takashi Agari, Takao Yasuhara, Jun Morimoto, Mihoko Okazaki, Hayato Takeuchi, Atsuhiko Toyoshima, Susumu Sasada, Aiko Shinko, Akihiko Kondo, Masahiro Kameda, Ikuko Miyazaki, Masato Asanuma, Cesario V Borlongan, Masahiro Nishibori, Isao Date

    Experimental neurology   275 Pt 1   220 - 31   2016年1月

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    記述言語:英語   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    The high mobility group box-1 (HMGB1) exists as an architectural nuclear protein in the normal state, but displays an inflammatory cytokine-like activity in the extracellular space under pathological condition. Inflammation in the pathogenesis of Parkinson's disease (PD) has been documented. In this study, we investigated the involvement of HMGB1 in the pathology and the neuroprotective effects of neutralizing anti-HMGB1 monoclonal antibody (mAb) on an animal model of PD. Adult female Sprague-Dawley rats were initially injected with 6-hydroxydopmaine (6-OHDA, 20 μg/4 μl) into the right striatum, then anti-HMGB1 mAb (1 mg/kg), or control mAb was intravenously administered immediately, at 6 and 24 h after 6-OHDA injection. The treatment with anti-HMGB1 mAb significantly preserved dopaminergic neurons in substantia nigra pars compacta and dopaminergic terminals inherent in the striatum, and attenuated PD behavioral symptoms compared to the control mAb-treated group. HMGB1 was retained in the nucleus of neurons and astrocytes by inhibiting the proinflammation-induced oxidative stress in the anti-HMGB1 mAb-treated group, whereas HMGB1 translocation was observed in neurons at 1 day and astrocytes at 7 days after 6-OHDA injection in the control mAb-treated group. Anti-HMGB1 mAb inhibited the activation of microglia, disruption of blood-brain-barrier (BBB), and the expression of inflammation cytokines such as IL-1β and IL-6. These results suggested that HMGB1 released from neurons and astrocytes was at least partly involved in the mechanism and pathway of degeneration of dopaminergic neurons induced by 6-OHDA exposure. Intravenous administration of anti-HMGB1 mAb stands as a novel therapy for PD possibly acting through the suppression of neuroinflammation and the attenuation of disruption of BBB associated with the disease.

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  • Anti-high mobility group box 1 antibody exerts neuroprotection in a rat model of Parkinson's disease

    Tatsuya Sasaki, Keyue Liu, Takashi Agari, Takao Yasuhara, Jun Morimoto, Mihoko Okazaki, Hayato Takeuchi, Atsuhiko Toyoshima, Susumu Sasada, Aiko Shinko, Akihiko Kondo, Masahiro Kameda, Ikuko Miyazaki, Masato Asanuma, Cesario V. Borlongan, Masahiro Nishibori, Isao Date

    EXPERIMENTAL NEUROLOGY   275   220 - 231   2016年1月

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    記述言語:英語   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    The high mobility group box-1 (HMGB1) exists as an architectural nuclear protein in the normal state, but displays an inflammatory cytokine-like activity in the extracellular space under pathological condition. Inflammation in the pathogenesis of Parkinson's disease (PD) has been documented. In this study, we investigated the involvement of HMGB1 in the pathology and the neuroprotective effects of neutralizing anti-HMGB1 monoclonal antibody (mAb) on an animal model of PD. Adult female Sprague-Dawley rats were initially injected with 6-hydroxydopmaine (6-OHDA, 20 mu g/4 mu l) into the right striatum, then anti-HMGB1 mAb (1 mg/kg), or control mAb was intravenously administered immediately, at 6 and 24 h after 6-OHDA injection. The treatment with anti-HMGB1 mAb significantly preserved dopaminergic neurons in substantia nigra pars compacta and dopaminergic terminals inherent in the striatum, and attenuated PD behavioral symptoms compared to the control mAb-treated group. HMGB1 was retained in the nucleus of neurons and astrocytes by inhibiting the proinflammation-induced oxidative stress in the anti-HMGB1 mAb-treated group, whereas HMGB1 translocation was observed in neurons at 1 day and astrocytes at 7 days after 6-OHDA injection in the control mAb-treated group. Anti-HMGB1 mAb inhibited the activation of microglia, disruption of blood-brain-barrier (BBB), and the expression of inflammation cytokines such as IL-1 beta. and IL-6. These results suggested that HMGB1 released from neurons and astrocytes was at least partly involved in the mechanism and pathway of degeneration of dopaminergic neurons induced by 6-0HDA exposure. Intravenous administration of anti-HMGB1 mAb stands as a novel therapy for PD possibly acting through the suppression of neuroinflammation and the attenuation of disruption of BOB associated with the disease. (C) 2015 Elsevier Inc. All rights reserved.

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  • Hybrid Microscopic-Endoscopic Surgery for Craniopharyngioma in Neurosurgical Suite: Technical Notes

    Tomotsugu Ichikawa, Yoshihiro Otani, Joji Ishida, Kentaro Fujii, Kazuhiko Kurozumi, Shigeki Ono, Isao Date

    WORLD NEUROSURGERY   85   340 - +   2016年1月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    OBJECTIVE: The best chance of curing craniopharyngioma is achieved by microsurgical total resection; however, its location adjacent to critical structures hinders complete resection without neurologic deterioration. Unrecognized residual tumor within microscopic blind spots might result in tumor recurrences. To improve outcomes, new techniques are necessary to visualize tissue within these blind spots. We examined the success of hybrid microscopic-endoscopic neurosurgery for craniopharyngioma in a neurosurgical suite.
    METHODS: Four children with craniopharyngiomas underwent microscopic resection. When the neurosurgeon was confident that most of the visible tumor was removed but was suspicious of residual tumor within the blind spot, he or she used an integrated endoscope-holder system to inspect and remove any residual tumor. Two ceiling monitors were mounted side by side in front of the surgeon to display both microscopic and endoscopic views and to view both monitors simultaneously.
    RESULTS: Surgery was performed in all patients via the frontobasal interhemispheric approach. Residual tumors were observed in the sella (2 patients), on the ventral surface of the chiasm and optic nerve (1 patient), and in the third ventricle (1 patient) and were resected to achieve total resection. Postoperatively, visual function was improved in 2 patients and none exhibited deterioration related to the surgery.
    CONCLUSIONS: Simultaneous microscopic and endoscopic observation with the use of dual monitors in a neurosurgical suite was ergonomically optimal for the surgeon to perform microsurgical procedures and to avoid traumatizing surrounding vessels or neural tissues. Hybrid microscopic-endoscopic neurosurgery may contribute to safe, less-invasive, and maximal resection to achieve better prognosis in children with craniopharyngioma.

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  • Hybrid Microscopic-Endoscopic Surgery for Craniopharyngioma in Neurosurgical Suite: Technical Notes. 国際誌

    Tomotsugu Ichikawa, Yoshihiro Otani, Joji Ishida, Kentaro Fujii, Kazuhiko Kurozumi, Shigeki Ono, Isao Date

    World neurosurgery   85   340 - 8   2016年1月

     詳細を見る

    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    OBJECTIVE: The best chance of curing craniopharyngioma is achieved by microsurgical total resection; however, its location adjacent to critical structures hinders complete resection without neurologic deterioration. Unrecognized residual tumor within microscopic blind spots might result in tumor recurrences. To improve outcomes, new techniques are necessary to visualize tissue within these blind spots. We examined the success of hybrid microscopic-endoscopic neurosurgery for craniopharyngioma in a neurosurgical suite. METHODS: Four children with craniopharyngiomas underwent microscopic resection. When the neurosurgeon was confident that most of the visible tumor was removed but was suspicious of residual tumor within the blind spot, he or she used an integrated endoscope-holder system to inspect and remove any residual tumor. Two ceiling monitors were mounted side by side in front of the surgeon to display both microscopic and endoscopic views and to view both monitors simultaneously. RESULTS: Surgery was performed in all patients via the frontobasal interhemispheric approach. Residual tumors were observed in the sella (2 patients), on the ventral surface of the chiasm and optic nerve (1 patient), and in the third ventricle (1 patient) and were resected to achieve total resection. Postoperatively, visual function was improved in 2 patients and none exhibited deterioration related to the surgery. CONCLUSIONS: Simultaneous microscopic and endoscopic observation with the use of dual monitors in a neurosurgical suite was ergonomically optimal for the surgeon to perform microsurgical procedures and to avoid traumatizing surrounding vessels or neural tissues. Hybrid microscopic-endoscopic neurosurgery may contribute to safe, less-invasive, and maximal resection to achieve better prognosis in children with craniopharyngioma.

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  • Hybrid Microscopic-Endoscopic Surgery for Craniopharyngioma in Neurosurgical Suite: Technical Notes

    Tomotsugu Ichikawa, Yoshihiro Otani, Joji Ishida, Kentaro Fujii, Kazuhiko Kurozumi, Shigeki Ono, Isao Date

    WORLD NEUROSURGERY   85   340 - +   2016年1月

     詳細を見る

    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    OBJECTIVE: The best chance of curing craniopharyngioma is achieved by microsurgical total resection; however, its location adjacent to critical structures hinders complete resection without neurologic deterioration. Unrecognized residual tumor within microscopic blind spots might result in tumor recurrences. To improve outcomes, new techniques are necessary to visualize tissue within these blind spots. We examined the success of hybrid microscopic-endoscopic neurosurgery for craniopharyngioma in a neurosurgical suite.
    METHODS: Four children with craniopharyngiomas underwent microscopic resection. When the neurosurgeon was confident that most of the visible tumor was removed but was suspicious of residual tumor within the blind spot, he or she used an integrated endoscope-holder system to inspect and remove any residual tumor. Two ceiling monitors were mounted side by side in front of the surgeon to display both microscopic and endoscopic views and to view both monitors simultaneously.
    RESULTS: Surgery was performed in all patients via the frontobasal interhemispheric approach. Residual tumors were observed in the sella (2 patients), on the ventral surface of the chiasm and optic nerve (1 patient), and in the third ventricle (1 patient) and were resected to achieve total resection. Postoperatively, visual function was improved in 2 patients and none exhibited deterioration related to the surgery.
    CONCLUSIONS: Simultaneous microscopic and endoscopic observation with the use of dual monitors in a neurosurgical suite was ergonomically optimal for the surgeon to perform microsurgical procedures and to avoid traumatizing surrounding vessels or neural tissues. Hybrid microscopic-endoscopic neurosurgery may contribute to safe, less-invasive, and maximal resection to achieve better prognosis in children with craniopharyngioma.

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  • Cerebral infarction arising from Takotsubo cardiomyopathy: Care report and literature review

    Otani Y, Tokunaga K, Kawauchi S, Inoue S, Watanabe K, Kiriyama H, Sakane K, Maekawa K, Date I, Matsumoto K

    NMC Case Report Journal   3   119 - 123   2016年

  • Cilengitide─脳腫瘍の治療:脳腫瘍の分子標的治療─

    黒住和彦, 石田穣治, 市川智継, 伊達 勲

    日本臨床 増刊号 脳腫瘍学─基礎研究と臨床研究の進歩─   74 ( Suppl 7 )   672 - 675   2016年

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  • 小児頭蓋骨形態異常における形成外科的アプローチ

    徳山英二郎, 亀田雅博, 山田 潔, 小野成紀, 伊達 勲, 木股敬裕

    小児の脳神経   40 ( 6 )   428 - 439   2016年

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  • 小児の脳神経外科手術室─イノベーション:現在そして未来─

    亀田雅博, 伊達 勲

    小児の脳神経   41 ( 2 )   209 - 215   2016年

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  • グリオーマの分子標的治療薬概論─脳腫瘍の治療:脳腫瘍の分子標的治療─

    黒住和彦, 石田穣治, 市川智継, 伊達 勲

    日本臨床 増刊号 脳腫瘍学─基礎研究と臨床研究の進歩─   74 ( Suppl 7 )   665 - 671   2016年

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  • A Segmental Copy Number Loss of the SFMBT1 Gene Is a Genetic Risk for Shunt-Responsive, Idiopathic Normal Pressure Hydrocephalus (iNPH): A Case-Control Study. 国際誌

    Hidenori Sato, Yoshimi Takahashi, Luna Kimihira, Chifumi Iseki, Hajime Kato, Yuya Suzuki, Ryosuke Igari, Hiroyasu Sato, Shingo Koyama, Shigeki Arawaka, Toru Kawanami, Masakazu Miyajima, Naoyuki Samejima, Shinya Sato, Masahiro Kameda, Shinya Yamada, Daisuke Kita, Mitsunobu Kaijima, Isao Date, Yukihiko Sonoda, Takamasa Kayama, Nobumasa Kuwana, Hajime Arai, Takeo Kato

    PloS one   11 ( 11 )   e0166615   2016年

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    記述言語:英語   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    Little is known about genetic risk factors for idiopathic normal pressure hydrocephalus (iNPH). We examined whether a copy number loss in intron 2 of the SFMBT1 gene could be a genetic risk for shunt-responsive, definite iNPH. Quantitative and digital PCR analyses revealed that 26.0% of shunt-responsive definite iNPH patients (n = 50) had such a genetic change, as compared with 4.2% of the healthy elderly (n = 191) (OR = 7.94, 95%CI: 2.82-23.79, p = 1.8 x 10-5) and 6.3% of patients with Parkinson's disease (n = 32) (OR = 5.18, 95%CI: 1.1-50.8, p = 0.038). The present study demonstrates that a copy number loss within intron 2 of the SFMBT1 gene may be a genetic risk factor for shunt-responsive definite iNPH.

    DOI: 10.1371/journal.pone.0166615

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  • Working Conditions and Lifestyle of Female Surgeons Affiliated to the Japan Neurosurgical Society: Findings of Individual and Institutional Surveys

    Takamitsu Fujimaki, Soichiro Shibui, Yoko Kato, Akira Matsumura, Mami Yamasaki, Isao Date, Kazuhiro Hongo, Satoshi Kuroda, Mitsunori Matsumae, Naoyuki Nakao, Kaori Sakurada, Shoko Shimokawa, Takamasa Kayama

    NEUROLOGIA MEDICO-CHIRURGICA   56 ( 11 )   704 - 708   2016年

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    記述言語:英語   出版者・発行元:JAPAN NEUROSURGICAL SOC  

    To investigate the working conditions of female neurosurgeons in Japan, two surveys were conducted by The Japan Neurosurgical Society: one involving female neurosurgeons themselves and the other involving the chiefs of neurosurgical departments. The responses were received from 224 (43.8%) female neurosurgeons and 496 (61.2%) departmental chiefs. About half (50.2%) of the female neurosurgeons were married and 39.2% had children (average number of children, 1.27). Their work was full-time in 80.6% of cases; on average, they worked 51.9 h per week, had night duty 2.8 times per month, and had 5.7 days off per month. Many of them stated that they were satisfied with their job status, but about half of them reported difficulty in maintaining a correct work-life balance. Among the institutions surveyed, 29% had female neurosurgeons. The survey of departmental chiefs revealed that the proxies for maternity leave were not available at most institutions, and that there was only limited availability of night child care (41%) or sick child care (39%); female neurosurgeons did not appear to be well-informed of these support systems. These findings suggest that apart from systematic approaches already in place, female neurosurgeons would prefer to have more understanding from their peers and chiefs.

    DOI: 10.2176/nmc.oa.2016-0119

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  • 外傷性椎骨動静脈瘻に対してinternal trappingで治療した1例

    西廣真吾, 杉生憲志, 菱川朋人, 平松匡文, 春間 純, 新治有径, 高杉祐二, 伊達 勲

    脳神経外科   44 ( 2 )   135 - 141   2016年

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  • 岡山大学におけるHybrid ORでの手術

    菱川朋人, 杉生憲志, 安原隆雄, 伊達 勲

    脳卒中の外科   44 ( 2 )   125 - 131   2016年

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  • 岡山大学におけるHybrid ORでの手術.

    菱川朋人, 杉生憲志, 安原隆雄, 伊達 勲

    脳卒中の外科   44 ( 2 )   125 - 131   2016年

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  • 中枢原発性悪性リンパ腫患者へのホスアプレピタント適応に関する検討─中枢原発性悪性リンパ腫2症例の考察─

    中本秋彦, 小川 敦, 市川智継, 黒住和彦, 村川公央, 矢尾和久, 北村佳久, 伊達 勲, 千堂年昭

    日本注射薬臨床情報学会誌   5   19 - 26   2016年

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  • 視床下核刺激療法がパーキンソン病の認知機能に及ぼす影響

    若森孝彰, 上利 崇, 佐々木達也, 岡崎三保子, 金 一徹, 桑原 研, 安原隆雄, 伊達 勲

    機能的脳神経外科   55   50 - 54   2016年

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  • 数値流体力学(CFD)を用いた片側顔面痙攣の神経血管圧迫部位における圧迫血管の局所血行力学

    佐藤 透, 小野田恵介, 伊達 勲, 市川智継, 上利 崇, 亀田雅博, 神原啓和, 西田あゆみ

    脳神経外科速報   26   56 - 66   2016年

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  • 小児の脳血管障害

    菱川朋人, 伊達 勲

    小児の脳神経   40 ( 3 )   211 - 218   2016年

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  • てんかんに対する再生医療の現況

    安原隆雄, 上利 崇, 亀田雅博, 佐々木達也, 近藤聡彦, 伊達 勲

    小児の脳神経   40 ( 5 )   361 - 367   2016年

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  • 第45回日本脳卒中の外科学会学術集会報告記

    伊達 勲

    JSA News   46   2 - 2   2016年

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  • 日本医学英語検定試験1級の現状

    伊達 勲

    Journal of Medical English Education   15 ( 3 )   90 - 92   2016年

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  • Endoscope-assisted resection of cavernous angioma at the foramen of Monro: a case report. 国際誌

    Yuji Matsumoto, Kazuhiko Kurozumi, Yousuke Shimazu, Tomotsugu Ichikawa, Isao Date

    SpringerPlus   5 ( 1 )   1820 - 1820   2016年

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    記述言語:英語   出版者・発行元:SPRINGER INTERNATIONAL PUBLISHING AG  

    INTRODUCTION: Intraventricular cavernous angiomas are rare pathological entities, and those located at the foramen of Monro are even rarer. We herein present a case of cavernous angioma at the foramen of Monro that was successfully treated by neuroendoscope-assisted surgical removal, and review the relevant literature. CASE PRESENTATION: A 65-year-old woman had experienced headache and vomiting for 10 days before admission to another hospital. Magnetic resonance imaging (MRI) showed a mass at the foramen of Monro, and obstructive hydrocephalus of both lateral ventricles. The patient was then referred to our hospital. Neurological examination on admission to our hospital showed memory disturbance (Mini-Mental State Examination 20/30) and wide-based gait. A cavernous angioma at the foramen of Monro was diagnosed based on the typical popcorn-like appearance of the lesion on MRI. The lesion was completely removed by neuroendoscope-assisted transcortical surgery with the Viewsite Brain Access System (Vycor Medical Inc., Boca Raton, FL), leading to a reduction in the size of the ventricles. The resected mass was histologically confirmed to be cavernous angioma. The patient's symptoms resolved immediately and there were no postoperative complications. CONCLUSION: Minimally invasive neuroendoscope-assisted surgery was used to successfully treat a cavernous angioma at the foramen of Monro.

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  • 磁場式ナビゲーション下に全摘し得た海綿静脈洞進展ACTH産生下垂体腺腫の1例

    冨田祐介, 黒住和彦, 寺坂友博, 稲垣兼一, 大塚文男, 伊達 勲

    脳神経外科   44 ( 6 )   473 - 479   2016年

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  • 術中画像支援・モニタリングを用いた頭蓋内海綿状血管腫に対する摘出術

    黒住和彦, 菱川朋人, 亀田雅博, 上利 崇, 市川智継, 伊達 勲

    脳卒中の外科   44 ( 4 )   295 - 301   2016年

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  • Transient middle cerebral artery occlusion model in the macaca fuscata using a novel intravascular technique

    Okuma Y, Liu K, Hishikawa T, Hirotsune N, Sugiu K, Nishino S, Nishibori M, Date I

    Journal of Neuroendovascular Therapy   10 ( 3 )   121 - 126   2016年

  • Transient middle cerebral artery occlusion model in the macaca fuscata using a novel intravascular technique

    Okuma Y, Liu K, Hishikawa T, Hirotsune N, Sugiu K, Nishino S, Nishibori M, Date I

    Journal of Neuroendovascular Therapy   10 ( 3 )   121 - 126   2016年

  • Electrical Stimulation for Central Nervous System Diseases: From the Aspect of Regenerative Medicine

    T. Yasuhara, M. Kameda, T. Agari, H. Takeuchi, J. Morimoto, M. Okazaki, K. Kin, A. Shinko, T. Baba, T. Morimoto, N. Tajiri, I. Date

    CELL TRANSPLANTATION   25 ( 4 )   777 - 777   2016年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:COGNIZANT COMMUNICATION CORP  

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  • Risk of rupture of unruptured cerebral aneurysms in elderly patients. 国際誌

    Tomohito Hishikawa, Isao Date, Koji Tokunaga, Shinjiro Tominari, Kazuhiko Nozaki, Yoshiaki Shiokawa, Kiyohiro Houkin, Yuichi Murayama, Toshihiro Ishibashi, Hiroyuki Takao, Toshikazu Kimura, Takeo Nakayama, Akio Morita

    Neurology   85 ( 21 )   1879 - 85   2015年11月

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    記述言語:英語   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    OBJECTIVES: The aim of this study was to identify risk factors for rupture of unruptured cerebral aneurysms (UCAs) in elderly Japanese patients aged 70 years or older. METHODS: The participants included all patients 70 years of age or older in 3 prospective studies in Japan (the Unruptured Cerebral Aneurysm Study of Japan [UCAS Japan], UCAS II, and the prospective study at the Jikei University School of Medicine). A total of 1,896 patients aged 70 years or older with 2,227 UCAs were investigated. The median and mean follow-up periods were 990 and 802.7 days, respectively. RESULTS: The mean aneurysm size was 6.2 ± 3.9 mm. Sixty-eight patients (3.6%) experienced subarachnoid hemorrhage during the follow-up period. Multivariable analysis per patient revealed that in patients aged 80 years or older (hazard ratio [HR], 2.02; 95% confidence interval [CI], 1.16-3.49, p = 0.012), aneurysms 7 mm or larger (HR, 3.08; 95% CI, 1.35-7.03, p = 0.007 for 7-9 mm; HR, 7.82; 95% CI, 3.60-16.98, p < 0.001 for 10-24 mm; and HR, 43.31; 95% CI, 12.55-149.42, p < 0.001 for ≥25 mm) and internal carotid-posterior communicating artery aneurysms (HR, 2.45; 95% CI, 1.23-4.88, p = 0.011) were independent predictors for UCA rupture in elderly patients. CONCLUSIONS: In our pooled analysis of prospective cohorts in Japan, patient age and aneurysm size and location were significant risk factors for UCA rupture in elderly patients.

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  • Risk of rupture of unruptured cerebral aneurysms in elderly patients

    Tomohito Hishikawa, Isao Date, Koji Tokunaga, Shinjiro Tominari, Kazuhiko Nozaki, Yoshiaki Shiokawa, Kiyohiro Houkin, Yuichi Murayama, Toshihiro Ishibashi, Hiroyuki Takao, Toshikazu Kimura, Takeo Nakayama, Akio Morita

    NEUROLOGY   85 ( 21 )   1879 - 1885   2015年11月

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    記述言語:英語   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Objectives:The aim of this study was to identify risk factors for rupture of unruptured cerebral aneurysms (UCAs) in elderly Japanese patients aged 70 years or older.Methods:The participants included all patients 70 years of age or older in 3 prospective studies in Japan (the Unruptured Cerebral Aneurysm Study of Japan [UCAS Japan], UCAS II, and the prospective study at the Jikei University School of Medicine). A total of 1,896 patients aged 70 years or older with 2,227 UCAs were investigated. The median and mean follow-up periods were 990 and 802.7 days, respectively.Results:The mean aneurysm size was 6.2 3.9 mm. Sixty-eight patients (3.6%) experienced subarachnoid hemorrhage during the follow-up period. Multivariable analysis per patient revealed that in patients aged 80 years or older (hazard ratio [HR], 2.02; 95% confidence interval [CI], 1.16-3.49, p = 0.012), aneurysms 7 mm or larger (HR, 3.08; 95% CI, 1.35-7.03, p = 0.007 for 7-9 mm; HR, 7.82; 95% CI, 3.60-16.98, p &lt; 0.001 for 10-24 mm; and HR, 43.31; 95% CI, 12.55-149.42, p &lt; 0.001 for 25 mm) and internal carotid-posterior communicating artery aneurysms (HR, 2.45; 95% CI, 1.23-4.88, p = 0.011) were independent predictors for UCA rupture in elderly patients.Conclusions:In our pooled analysis of prospective cohorts in Japan, patient age and aneurysm size and location were significant risk factors for UCA rupture in elderly patients.

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  • Evaluation of extracellular matrix protein CCN1 as a prognostic factor for glioblastoma.

    Joji Ishida, Kazuhiko Kurozumi, Tomotsugu Ichikawa, Yoshihiro Otani, Manabu Onishi, Kentaro Fujii, Yosuke Shimazu, Tetsuo Oka, Toshihiko Shimizu, Isao Date

    Brain tumor pathology   32 ( 4 )   245 - 52   2015年10月

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    記述言語:英語   出版者・発行元:SPRINGER JAPAN KK  

    Recently, research efforts in identifying prognostic molecular biomarkers for malignant glioma have intensified. Cysteine-rich protein 61 (CCN1) is one of the CCN family of matricellular proteins that promotes cell growth and angiogenesis in cancers through its interaction with several integrins. In this study, we investigated the relationships among CCN1, O(6)-methylguanine-DNA methyltransferase expression, the tumor removal rate, and prognosis in 46 glioblastoma patients treated at the Okayama University Hospital. CCN1 expression was high in 31 (67 %) of these patients. The median progression-free survival (PFS) and overall survival (OS) times of patients with high CCN1 expression was significantly shorter than those of patients with low CCN1 expression (p < 0.005). In a multivariate Cox analysis, CCN1 proved to be an independent prognostic factor for patient survival [PFS, hazard ratio (HR) = 3.53 (1.55-8.01), p = 0.003 and OS, HR = 3.05 (1.35-6.87), p = 0.007]. Moreover, in the 31 patients who underwent gross total resection, the PFS and OS times of those with high CCN1 expression were significantly shorter than those with low CCN1 expression. It was concluded that CCN1 might emerge as a significant prognostic factor regarding the prognosis of glioblastoma patients.

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  • Evaluation of extracellular matrix protein CCN1 as a prognostic factor for glioblastoma

    Joji Ishida, Kazuhiko Kurozumi, Tomotsugu Ichikawa, Yoshihiro Otani, Manabu Onishi, Kentaro Fujii, Yosuke Shimazu, Tetsuo Oka, Toshihiko Shimizu, Isao Date

    BRAIN TUMOR PATHOLOGY   32 ( 4 )   245 - 252   2015年10月

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    記述言語:英語   出版者・発行元:SPRINGER JAPAN KK  

    Recently, research efforts in identifying prognostic molecular biomarkers for malignant glioma have intensified. Cysteine-rich protein 61 (CCN1) is one of the CCN family of matricellular proteins that promotes cell growth and angiogenesis in cancers through its interaction with several integrins. In this study, we investigated the relationships among CCN1, O-6-methylguanine-DNA methyltransferase expression, the tumor removal rate, and prognosis in 46 glioblastoma patients treated at the Okayama University Hospital. CCN1 expression was high in 31 (67 %) of these patients. The median progression-free survival (PFS) and overall survival (OS) times of patients with high CCN1 expression was significantly shorter than those of patients with low CCN1 expression (p &lt; 0.005). In a multivariate Cox analysis, CCN1 proved to be an independent prognostic factor for patient survival [PFS, hazard ratio (HR) = 3.53 (1.55-8.01), p = 0.003 and OS, HR = 3.05 (1.35-6.87), p = 0.007]. Moreover, in the 31 patients who underwent gross total resection, the PFS and OS times of those with high CCN1 expression were significantly shorter than those with low CCN1 expression. It was concluded that CCN1 might emerge as a significant prognostic factor regarding the prognosis of glioblastoma patients.

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  • Combined Transarterial and Transvenous Approach for Curative Obliteration of Klippel-Trenaunay-Weber Syndrome-Associated Spinal Perimedullary Arteriovenous Fistulas

    K. Tokunaga, T. Hishikawa, K. Sugiu, I. Date

    CLINICAL NEURORADIOLOGY   25 ( 3 )   291 - 294   2015年9月

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    記述言語:英語   出版者・発行元:SPRINGER HEIDELBERG  

    DOI: 10.1007/s00062-014-0319-1

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  • Combined Transarterial and Transvenous Approach for Curative Obliteration of Klippel-Trenaunay-Weber Syndrome-Associated Spinal Perimedullary Arteriovenous Fistulas

    K. Tokunaga, T. Hishikawa, K. Sugiu, I. Date

    CLINICAL NEURORADIOLOGY   25 ( 3 )   291 - 294   2015年9月

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    記述言語:英語   出版者・発行元:SPRINGER HEIDELBERG  

    DOI: 10.1007/s00062-014-0319-1

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  • [Molecular-Targeted Drug Therapy for Glioma Angiogenesis and Invasion].

    Kazuhiko Kurozumi, Isao Date

    No shinkei geka. Neurological surgery   43 ( 8 )   691 - 701   2015年8月

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    記述言語:日本語   出版者・発行元:Igaku-Shoin Ltd  

    DOI: 10.11477/mf.1436203103

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  • Annexin A2 regulates angiogenesis and invasion phenotypes of malignant glioma

    Manabu Onishi, Tomotsugu Ichikawa, Kazuhiko Kurozumi, Satoshi Inoue, Tomoko Maruo, Yoshihiro Otani, Kentaro Fujii, Joji Ishida, Yosuke Shimazu, Koichi Yoshida, Hiroyuki Michiue, E. Antonio Chiocca, Isao Date

    BRAIN TUMOR PATHOLOGY   32 ( 3 )   184 - 194   2015年7月

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    記述言語:英語   出版者・発行元:SPRINGER JAPAN KK  

    We have established a pair of animal models (J3T-1 and J3T-2) with different invasive and angiogenic phenotypes, and demonstrated that annexin A2 is expressed at higher levels in J3T-1 than J3T-2 cells. The function of annexin A2 in relation to angiogenesis and invasion was investigated using these models. Stable silencing or overexpression of annexin A2 in J3T-1 and J3T-2 cells (J3T-1shA and J3T-2A cells) was established and used. Thirty human glioblastoma samples were evaluated for expression of annexin A2, vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF). Immunohistochemical and quantitative reverse-transcription polymerase chain reaction analyses revealed higher expression of annexin A2, VEGF and PDGF in J3T-1 and J3T-2A cells. Cultured J3T-1 and J3T-2A cells exhibited higher adhesive ability to endothelial cells. Histopathological analysis of animal brain tumors revealed that J3T-1 and J3T-2A tumors displayed marked angiogenesis and invasion along the neovasculature, whereas J3T-2 and J3T-1shA tumors exhibited diffuse, infiltrative invasion without angiogenesis. Positive expression of annexin A2 was observed in tumor cells surrounding dilated vessels in 25/30 human glioblastoma specimens. Our results reveal that the phenotype of glioma invasion is closely related to angiogenesis. We identify annexin A2 as a factor regulating angiogenesis and invasion of malignant gliomas.

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  • Annexin A2 regulates angiogenesis and invasion phenotypes of malignant glioma.

    Manabu Onishi, Tomotsugu Ichikawa, Kazuhiko Kurozumi, Satoshi Inoue, Tomoko Maruo, Yoshihiro Otani, Kentaro Fujii, Joji Ishida, Yosuke Shimazu, Koichi Yoshida, Hiroyuki Michiue, E Antonio Chiocca, Isao Date

    Brain tumor pathology   32 ( 3 )   184 - 94   2015年7月

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    記述言語:英語   出版者・発行元:SPRINGER JAPAN KK  

    We have established a pair of animal models (J3T-1 and J3T-2) with different invasive and angiogenic phenotypes, and demonstrated that annexin A2 is expressed at higher levels in J3T-1 than J3T-2 cells. The function of annexin A2 in relation to angiogenesis and invasion was investigated using these models. Stable silencing or overexpression of annexin A2 in J3T-1 and J3T-2 cells (J3T-1shA and J3T-2A cells) was established and used. Thirty human glioblastoma samples were evaluated for expression of annexin A2, vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF). Immunohistochemical and quantitative reverse-transcription polymerase chain reaction analyses revealed higher expression of annexin A2, VEGF and PDGF in J3T-1 and J3T-2A cells. Cultured J3T-1 and J3T-2A cells exhibited higher adhesive ability to endothelial cells. Histopathological analysis of animal brain tumors revealed that J3T-1 and J3T-2A tumors displayed marked angiogenesis and invasion along the neovasculature, whereas J3T-2 and J3T-1shA tumors exhibited diffuse, infiltrative invasion without angiogenesis. Positive expression of annexin A2 was observed in tumor cells surrounding dilated vessels in 25/30 human glioblastoma specimens. Our results reveal that the phenotype of glioma invasion is closely related to angiogenesis. We identify annexin A2 as a factor regulating angiogenesis and invasion of malignant gliomas.

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  • Intra-Arterial Transplantation of Allogeneic Mesenchymal Stem Cells Mounts Neuroprotective Effects in a Transient Ischemic Stroke Model in Rats: Analyses of Therapeutic Time Window and Its Mechanisms

    Atsuhiko Toyoshima, Takao Yasuhara, Masahiro Kameda, Jun Morimoto, Hayato Takeuchi, Feifei Wang, Tatsuya Sasaki, Susumu Sasada, Aiko Shinko, Takaaki Wakamori, Mihoko Okazaki, Akihiko Kondo, Takashi Agari, Cesario V. Borlongan, Isao Date

    PLOS ONE   10 ( 6 )   10.1371/journal.pone.0127302   2015年6月

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    記述言語:英語   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    Objective
    Intra-arterial stem cell transplantation exerts neuroprotective effects for ischemic stroke. However, the optimal therapeutic time window and mechanisms have not been completely understood. In this study, we investigated the relationship between the timing of intra-arterial transplantation of allogeneic mesenchymal stem cells (MSCs) in ischemic stroke model in rats and its efficacy in acute phase.
    Methods
    Adult male Wistar rats weighing 200 to 250g received right middle cerebral artery occlusion (MCAO) for 90 minutes. MSCs (1x10(6)cells/ 1ml PBS) were intra-arterially injected at either 1, 6, 24, or 48 hours (1, 6, 24, 48h group) after MCAO. PBS (1ml) was intra-arterially injected to control rats at 1 hour after MCAO. Behavioral test was performed immediately after reperfusion, and at 3, 7 days after MCAO using the Modified Neurological Severity Score (mNSS). Rats were euthanized at 7 days after MCAO for evaluation of infarct volumes and the migration of MSCs. In order to explore potential mechanisms of action, the upregulation of neurotrophic factor and chemotactic cytokine (bFGF, SDF-1 alpha) induced by cell transplantation was examined in another cohort of rats that received intra-arterial transplantation at 24 hours after recanalization then euthanized at 7 days after MCAO for protein assays.
    Results
    Behavioral test at 3 and 7 days after transplantation revealed that stroke rats in 24h group displayed the most robust significant improvements in mNSS compared to stroke rats in all other groups (p's&lt;0.05). Similarly, the infarct volumes of stroke rats in 24h group were much significantly decreased compared to those in all other groups (p's&lt;0.05). These observed behavioral and histological effects were accompanied by MSC survival and migration, with the highest number of integrated MSCs detected in the 24h group. Moreover, bFGF and SDF-1 alpha levels of the infarcted cortex were highly elevated in the 24h group compared to control group (p's&lt;0.05).
    Conclusions
    These results suggest that intra-arterial allogeneic transplantation of MSCs provides post-stroke functional recovery and reduction of infarct volumes in ischemic stroke model of rats. The upregulation of bFGF and SDF-1 alpha likely played a key mechanistic role in enabling MSC to afford functional effects in stroke. MSC transplantation at 24 hours after recanalization appears to be the optimal timing for ischemic stroke model, which should guide the design of clinical trials of cell transplantation for stroke patients.

    DOI: 10.1371/journal.pone.0127302

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  • 中枢神経原発リンパ腫に対する非照射治癒を目指した移植併用超大量化学療法

    市川 智継, 近藤 英生, 黒住 和彦, 大谷 理浩, 前田 嘉信, 吉野 正, 谷本 光音, 伊達 勲

    日本リンパ網内系学会会誌   55   92 - 92   2015年6月

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    記述言語:日本語   出版者・発行元:(一社)日本リンパ網内系学会  

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  • Integrin antagonist augments the therapeutic effect of adenovirus-mediated REIC/Dkk-3 gene therapy for malignant glioma

    Y. Shimazu, K. Kurozumi, T. Ichikawa, K. Fujii, M. Onishi, J. Ishida, T. Oka, M. Watanabe, Y. Nasu, H. Kumon, I. Date

    GENE THERAPY   22 ( 2 )   146 - 154   2015年2月

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    記述言語:英語   出版者・発行元:NATURE PUBLISHING GROUP  

    Reduced expression in immortalized cells/Dickkopf-3 (REIC/Dkk-3) was identified as a gene whose expression is reduced in many human cancers. REIC/Dkk-3 expression is also downregulated in malignant glioma and regulates cell growth through caspase-dependent apoptosis. cRGD (EMD121974), an antagonist of integrins, has demonstrated preclinical efficacy against malignant glioma. In this study, we investigated the antiglioma effect of combination therapy using an adenovirus vector carrying REIC/Dkk-3 (Ad-REIC) and cRGD. Quantitative real-time reverse-transcription PCR revealed the reduction of REIC/Dkk-3 mRNA levels in malignant glioma cell lines. The reduction of REIC/Dkk-3 protein expression in malignant glioma cell lines was also confirmed with western blot analysis. After treatment with Ad-REIC and cRGD, the proliferative rate of malignant glioma cells was significantly reduced in a time-dependent manner. In vivo, there was a statistically significant increase in the survival of mice treated with Ad-REIC and cRGD combination therapy compared with Ad-REIC monotherapy. We identified an apoptotic effect following monotherapy with Ad-REIC. Moreover, cRGD augmented the antiglioma efficacy of Ad-REIC. These results may lead to a promising new approach for the treatment of malignant glioma.

    DOI: 10.1038/gt.2014.100

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  • Integrin antagonist augments the therapeutic effect of adenovirus-mediated REIC/Dkk-3 gene therapy for malignant glioma

    Y. Shimazu, K. Kurozumi, T. Ichikawa, K. Fujii, M. Onishi, J. Ishida, T. Oka, M. Watanabe, Y. Nasu, H. Kumon, I. Date

    GENE THERAPY   22 ( 2 )   146 - 154   2015年2月