2025/01/08 更新

写真a

ウ エイカ
于 英花
Yu Yinghua
所属
ヘルスシステム統合科学学域 准教授(特任)
職名
准教授(特任)
外部リンク

学位

  • 博士(工学) ( 岡山大学 )

  • 修士 ( 香川大学 )

研究キーワード

  • レイヤー fMRI

  • 高空間分解能fMRI

  • 触覚

  • 体性感覚野

  • 予測脳

  • 認知神経科学

研究分野

  • ライフサイエンス / 認知脳科学

  • ライフサイエンス / 基盤脳科学  / High-Resolution fMRI

学歴

  • 岡山大学    

    2010年4月 - 2013年3月

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経歴

  • 岡山大学   学術研究院ヘルスシステム統合科学学域   特任准教授

    2024年4月 - 現在

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  • 岡山大学   学術研究院ヘルスシステム統合科学学域   助教

    2021年4月 - 2024年3月

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  • 大阪大学 大学院生命機能研究科 招へい教員

    2020年8月 - 2021年3月

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  • 国立研究開発法人情報通信研究機構   研究員

    2020年1月 - 2021年3月

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  • 岡山大学   大学院ヘルスシステム統合科学研究科   日本学術振興会 特別研究員(RPD)

    2017年4月 - 2019年12月

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  • アメリカ国立衛生研究所(NIH)

    2016年10月 - 2020年12月

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  • 岡山大学大学院 自然科学研究科

    2013年4月 - 2017年3月

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▼全件表示

 

論文

  • The Impact of Selective Spatial Attention on Auditory–Tactile Integration: An Event-Related Potential Study

    Weichao An, Nan Zhang, Shengnan Li, Yinghua Yu, Jinglong Wu, Jiajia Yang

    Brain Sciences   14 ( 12 )   1258 - 1258   2024年12月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:MDPI AG  

    Background: Auditory–tactile integration is an important research area in multisensory integration. Especially in special environments (e.g., traffic noise and complex work environments), auditory–tactile integration is crucial for human response and decision making. We investigated the influence of attention on the temporal course and spatial distribution of auditory–tactile integration. Methods: Participants received auditory stimuli alone, tactile stimuli alone, and simultaneous auditory and tactile stimuli, which were randomly presented on the left or right side. For each block, participants attended to all stimuli on the designated side and detected uncommon target stimuli while ignoring all stimuli on the other side. Event-related potentials (ERPs) were recorded via 64 scalp electrodes. Integration was quantified by comparing the response to the combined stimulus to the sum of the responses to the auditory and tactile stimuli presented separately. Results: The results demonstrated that compared to the unattended condition, integration occurred earlier and involved more brain regions in the attended condition when the stimulus was presented in the left hemispace. The unattended condition involved a more extensive range of brain regions and occurred earlier than the attended condition when the stimulus was presented in the right hemispace. Conclusions: Attention can modulate auditory–tactile integration and show systematic differences between the left and right hemispaces. These findings contribute to the understanding of the mechanisms of auditory–tactile information processing in the human brain.

    DOI: 10.3390/brainsci14121258

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  • Tactile temporal predictions: The influence of conditional probability

    Rongxia Ren, Weichao An, Yinghua Yu, Xiaoyu Tang, Yoshimichi Ejima, Jinglong Wu, Jiajia Yang

    i-Perception   15 ( 4 )   2024年7月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:SAGE Publications  

    Predicting the timing of incoming information allows brain to optimize information processing in dynamic environments. However, the effects of temporal predictions on tactile perception are not well established. In this study, two experiments were conducted to determine how temporal predictions interact with conditional probabilities in tactile perceptual processing. In Experiment 1, we explored the range of the interval between preceding ready cues and imperative targets in which temporal prediction effects can be observed. This prediction effect was observed for intervals of 500 and 1,000 ms. In Experiment 2, we investigated the benefits of temporal predictions on tactile perception while manipulating the conditional probability (setting the stimulus onset earlier or later than the predicted moment in short and long intervals). Our results revealed that this effect became stronger as the probability of the stimulus at the predicted time point increased under short-interval conditions. Together, our results show that the difficulty of transferring processing resources increases in temporally dynamic environments, suggesting a greater subjective cost associated with maladaptive responses to temporally uncertain events.

    DOI: 10.1177/20416695241264736

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    その他リンク: https://journals.sagepub.com/doi/full-xml/10.1177/20416695241264736

  • Go/No-Go Ratios Modulate Inhibition-Related Brain Activity: An Event-Related Potential Study

    Nan Zhang, Weichao An, Yinghua Yu, Jinglong Wu, Jiajia Yang

    Brain Sciences   14 ( 5 )   414 - 414   2024年4月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:MDPI AG  

    (1) Background: Response inhibition refers to the conscious ability to suppress behavioral responses, which is crucial for effective cognitive control. Currently, research on response inhibition remains controversial, and the neurobiological mechanisms associated with response inhibition are still being explored. The Go/No-Go task is a widely used paradigm that can be used to effectively assess response inhibition capability. While many studies have utilized equal numbers of Go and No-Go trials, how different ratios affect response inhibition remains unknown; (2) Methods: This study investigated the impact of different ratios of Go and No-Go conditions on response inhibition using the Go/No-Go task combined with event-related potential (ERP) techniques; (3) Results: The results showed that as the proportion of Go trials decreased, behavioral performance in Go trials significantly improved in terms of response time, while error rates in No-Go trials gradually decreased. Additionally, the NoGo-P3 component at the central average electrodes (Cz, C1, C2, FCz, FC1, FC2, PCz, PC1, and PC2) exhibited reduced amplitude and latency; (4) Conclusions: These findings indicate that different ratios in Go/No-Go tasks influence response inhibition, with the brain adjusting processing capabilities and rates for response inhibition. This effect may be related to the brain’s predictive mechanism model.

    DOI: 10.3390/brainsci14050414

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  • Event-related potential evidence for tactile orientation processing in the human brain

    Jiajia Yang, Rongxia Ren, Yinghua Yu, Wu Wang, Xiaoyu Tang, Yoshimichi Ejima, Jinglong Wu

    Experimental Brain Research   242 ( 4 )   809 - 817   2024年2月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    Abstract

    It is well known that information on stimulus orientation plays an important role in sensory processing. However, the neural mechanisms underlying somatosensory orientation perception are poorly understood. Adaptation has been widely used as a tool for examining sensitivity to specific features of sensory stimuli. Using the adaptation paradigm, we measured event-related potentials (ERPs) in response to tactile orientation stimuli presented pseudo-randomly to the right-hand palm in trials with all the same or different orientations. Twenty participants were asked to count the tactile orientation stimuli. The results showed that the adaptation-related N60 component was observed around contralateral central-parietal areas, possibly indicating orientation processing in the somatosensory regions. Conversely, the adaptation-related N120 component was identified bilaterally across hemispheres, suggesting the involvement of the frontoparietal circuitry in further tactile orientation processing. P300 component was found across the whole brain in all conditions and was associated with task demands, such as attention and stimulus counting. These findings help provide an understanding of the mechanisms of tactile orientation processing in the human brain.

    DOI: 10.1007/s00221-024-06783-1

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    その他リンク: https://link.springer.com/article/10.1007/s00221-024-06783-1/fulltext.html

  • Tactile angle discriminability improvement: contributions of working memory training and continuous attended sensory input

    Wu Wang, Jiajia Yang, Yinghua Yu, Huazhi Li, Yulong Liu, Yiyang Yu, Jiabin Yu, Xiaoyu Tang, Jingjing Yang, Satoshi Takahashi, Yoshimichi Ejima, Jinglong Wu

    Journal of Neurophysiology   127 ( 5 )   1398 - 1406   2022年5月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:American Physiological Society  

    Perceptual learning is not always specific to the trained task and stimuli. We demonstrate that both continuous attended sensory input and improved WM capacity can be used to enhance tactile angle discrimination (TAD) ability. Moreover, WM capacity improvement is important in generalizing the training effect to the TAD ability. These findings contribute to understanding the mechanism of perceptual learning generalization across tasks.

    DOI: 10.1152/jn.00529.2021

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  • Layer-specific activation in human primary somatosensory cortex during tactile temporal prediction error processing

    Yinghua Yu, Laurentius Huber, Jiajia Yang, Masaki Fukunaga, Yuhui Chai, David C. Jangraw, Gang Chen, Daniel A. Handwerker, Peter J. Molfese, Yoshimichi Ejima, Norihiro Sadato, Jinglong Wu, Peter A. Bandettini

    NeuroImage   248   118867 - 118867   2022年3月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.neuroimage.2021.118867

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  • Global surface features contribute to human haptic roughness estimations

    Huazhi Li, Jiajia Yang, Yinghua Yu, Wu Wang, Yulong Liu, Mengni Zhou, Qingqing Li, Jingjing Yang, Shiping Shao, Satoshi Takahashi, Yoshimichi Ejima, Jinglong Wu

    Experimental Brain Research   240 ( 3 )   773 - 789   2022年3月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    Abstract

    Previous studies have paid special attention to the relationship between local features (e.g., raised dots) and human roughness perception. However, the relationship between global features (e.g., curved surface) and haptic roughness perception is still unclear. In the present study, a series of roughness estimation experiments was performed to investigate how global features affect human roughness perception. In each experiment, participants were asked to estimate the roughness of a series of haptic stimuli that combined local features (raised dots) and global features (sinusoidal-like curves). Experiments were designed to reveal whether global features changed their haptic roughness estimation. Furthermore, the present study tested whether the exploration method (direct, indirect, and static) changed haptic roughness estimations and examined the contribution of global features to roughness estimations. The results showed that sinusoidal-like curved surfaces with small periods were perceived to be rougher than those with large periods, while the direction of finger movement and indirect exploration did not change this phenomenon. Furthermore, the influence of global features on roughness was modulated by local features, regardless of whether raised-dot surfaces or smooth surfaces were used. Taken together, these findings suggested that an object’s global features contribute to haptic roughness perceptions, while local features change the weight of the contribution that global features make to haptic roughness perceptions.

    DOI: 10.1007/s00221-021-06289-0

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    その他リンク: https://link.springer.com/article/10.1007/s00221-021-06289-0/fulltext.html

  • Linking cortical circuit models to human cognition with laminar fMRI

    Jiajia Yang, Laurentius Huber, Yinghua Yu, Peter A. Bandettini

    Neuroscience & Biobehavioral Reviews   128   467 - 478   2021年9月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.neubiorev.2021.07.005

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  • A New Method for Haptic Shape Discriminability Detection

    Yulong Liu, Jiajia Yang, Yinghua Yu, Yiyang Yu, Wu Wang, Huazhi Li, Satoshi Takahashi, Yoshimichi Ejima, Qiong Wu, Jinglong Wu

    Applied Sciences   11 ( 15 )   7049 - 7049   2021年7月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:MDPI AG  

    Touch shape discrimination is not only closely related to tactile mechanoreceptors but also higher cognitive function. However, previous shape discrimination methods are difficult to complete in a short time, and the devices are complicated to operate and not user-friendly for nonprofessionals. Here, we propose a new method, the evaluation quantity of which is the angle discrimination threshold. In addition, to make this method easy to use for nonprofessionals, we designed a haptic angle sorting system, including the device and software. To evaluate this method, the angle sorting and two-angle discrimination experiments were compared, and it was found that participants spent significantly less time in the former experiment than in the latter. At the same time, there is a strong correlation between the performance of angle sorting and two-angle discrimination, which shows that the angle threshold obtained by the new method can also be used to evaluate the ability of touch discrimination. Moreover, the angle sorting results of different age groups also further demonstrate the feasibility of the method. The efficiency of this new method and the effectiveness of the system also provide a convenient means for evaluating haptic shape discrimination, which may have potential clinical application value in the early diagnosis of peripheral neuropathy and even in the evaluation of cognitive function.

    DOI: 10.3390/app11157049

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  • Improving Visual Working Memory With Training on a Tactile Orientation Sequence Task in Humans

    Ting Guo, Yanna Ren, Yinghua Yu, Yiyang Yu, Yuuki Hasegawa, Qiong Wu, Jiajia Yang, Satoshi Takahashi, Yoshimichi Ejima, Jinglong Wu

    SAGE Open   11 ( 3 )   215824402110315 - 215824402110315   2021年7月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:SAGE Publications  

    Working memory refers to the cognitive capacity to temporarily store and manipulate information from multiple sensory domains. Recent studies have shown that cognitive training can improve performance in both visual working memory and tactile working memory tasks. However, it is still unclear whether the effects of training can be transferred from one sensory modality to another. The current study assessed whether the training effect of the tactile orientation sequence task could transfer to visual orientation sequence and visuospatial working memory tasks. The results showed that participants’ accuracy in the tactile orientation sequence task was significantly increased after 9 days of training compared with that before training. Remarkably, participants’ accuracy in both the visual orientation sequence task and the visuospatial task was significantly improved after 9 days of training. These results suggest that it is possible to improve visual working memory through a transfer effect from tactile task training without practice in the visual domain, which opens a wide range of applications for tactile orientation sequence tasks.

    DOI: 10.1177/21582440211031549

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    その他リンク: http://journals.sagepub.com/doi/full-xml/10.1177/21582440211031549

  • Different activation signatures in the primary sensorimotor and higher-level regions for haptic three-dimensional curved surface exploration

    Jiajia Yang, Peter J. Molfese, Yinghua Yu, Daniel A. Handwerker, Gang Chen, Paul A. Taylor, Yoshimichi Ejima, Jinglong Wu, Peter A. Bandettini

    NeuroImage   231   117754 - 117754   2021年5月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.neuroimage.2021.117754

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  • Layer-specific activation of prediction in the human midcingulate cortex

    Jiajia Yang, Masaki Fukunaga, Yinghua Yu, Laurentius Huber, Peter A Bandettini, Norihiro Sadato

    Proc. Intl. Soc. Mag. Reson. Med.   29   3369   2021年5月

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  • Functional heterogeneity in the left lateral posterior parietal cortex during visual and haptic crossmodal dot‐surface matching

    Jiajia Yang, Yinghua Yu, Hiroaki Shigemasu, Hiroshi Kadota, Kiyoshi Nakahara, Takanori Kochiyama, Yoshimichi Ejima, Jinglong Wu

    Brain and Behavior   11 ( 3 )   2021年3月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1002/brb3.2033

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    その他リンク: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/brb3.2033

  • Visual Orientation Sequence Task enhances Working Memory in Younger and Older Adults

    Ting Guo, Yanna Ren, Yinghua Yu, Yiyang Yu, Seongyeol Yun, Qiong Wu, Jiajia Yang, Satoshi Takahashi, Yoshimichi Ejima, Jinglong Wu

    2020 IEEE International Conference on Mechatronics and Automation (ICMA)   2020年10月

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    掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:IEEE  

    DOI: 10.1109/icma49215.2020.9233631

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  • Tactile Semiautomatic Passive-Finger Angle Stimulator (TSPAS). 国際誌

    Wu Wang, Jiajia Yang, Yinghua Yu, Qiong Wu, Satoshi Takahashi, Yoshimichi Ejima, Jinglong Wu

    Journal of visualized experiments : JoVE   ( 161 )   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Passive tactile perception is the ability to passively and statically perceive stimulus information coming from the skin; for example, the ability to sense spatial information is the strongest in the skin on the hands. This ability is termed tactile spatial acuity, and is measured by the tactile threshold or discrimination threshold. At present, the two-point threshold is extensively used as a measure of tactile spatial acuity, although many studies have indicated that critical deficits exist in two-point discrimination. Therefore, a computer-controlled tactile stimulus system was developed, the tactile semiautomated passive-finger angle stimulator (TSPAS), using the tactile angle discrimination threshold as a new measure for tactile spatial acuity. The TSPAS is a simple, easily operated system that applies raised angle stimuli to a subject's passive fingerpad, while controlling movement speed, distance, and contact duration. The components of the TSPAS are described in detail as well as the procedure to calculate the tactile angle discrimination threshold.

    DOI: 10.3791/61218

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  • Tactile angle discriminability improvement: roles of training time intervals and different types of training tasks. 国際誌

    Wu Wang, Jiajia Yang, Yinghua Yu, Qiong Wu, Jiabin Yu, Satoshi Takahashi, Yoshimichi Ejima, Jinglong Wu

    Journal of neurophysiology   122 ( 5 )   1918 - 1927   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Perceptual learning, which is not limited to sensory modalities such as vision and touch, emerges within a training session and between training sessions and is accompanied by the remodeling of neural connections in the cortex. However, limited knowledge exists regarding perceptual learning between training sessions. Although tactile studies have paid attention to between-session learning effects, there have been few studies asking fundamental questions regarding whether the time interval between training sessions affects tactile perceptual learning and generalization across tactile tasks. We investigated the effects of different training time intervals on the consecutive performance of a tactile angle discrimination (AD) task and a tactile orientation discrimination (OD) task training on tactile angle discriminability. The results indicated that in the short-interval training group, AD task performance significantly improved in the early stage of learning and nearly plateaued in the later stage, whereas in the long-interval training group, significant improvement was delayed and then also nearly plateaued in the later stage; additionally, improved OD task performance resulted in improved AD task performance. These findings suggest that training time interval affects the early stage of learning but not the later stage and that generalization occurs between different types of tactile tasks.NEW & NOTEWORTHY Perceptual learning, which constitutes important foundations of complicated cognitive processes, is learning better perception skills. We demonstrate that training time interval can affect the early stage of learning but not the later stage. Moreover, a tactile orientation discrimination training task can also improve tactile angle discrimination performance. These findings may expand the characteristics of between-session learning and help understand the mechanism of the generalization across tactile tasks.

    DOI: 10.1152/jn.00161.2019

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  • Stroking hardness changes the perception of affective touch pleasantness across different skin sites. 国際誌

    Jiabin Yu, Jiajia Yang, Yinghua Yu, Qiong Wu, Satoshi Takahashi, Yoshimichi Ejima, Jinglong Wu

    Heliyon   5 ( 8 )   e02141   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Human unmyelinated tactile afferents (CT afferents) in hairy skin are thought to be involved in the transmission of affective aspects of touch. How the perception of affective touch differs across human skin has made substantial progress; however, the majority of previous studies have mainly focused on the relationship between stroking velocities and pleasantness ratings. Here, we investigate how stroking hardness affects the perception of affective touch. Affective tactile stimulation was given with four different hardness of brushes at three different forces, which were presented to either palm or forearm. To quantify the physical factors of the stimuli (brush hardness), ten naïve, healthy participants assessed brush hardness using a seven-point scale. Based on these ten participants, five more participants were added to rate the hedonic value of brush stroking using a visual analogue scale (VAS). We found that pleasantness ratings over the skin resulted in a preference for light, soft stroking, which was rated as more pleasant when compared to heavy, hard stroking. Our results show that the hairy skin of the forearm is more susceptible to stroking hardness than the glabrous of the palm in terms of the perception of pleasantness. These findings of the current study extend the growing literature related to the effect of stroking characteristics on pleasantness ratings.

    DOI: 10.1016/j.heliyon.2019.e02141

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  • Tactile Training Improvement of Same-orientation but Not Different-orientation Discrimination

    Wu Wang, Jiajia Yang, Yinghua Yu, Qiong Wu, Qingqing Li, Jiabin Yu, Satoshi Takahashi, Yoshimichi Ejima, Jinglong Wu

    2019 IEEE International Conference on Mechatronics and Automation (ICMA)   2019年8月

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    掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:IEEE  

    DOI: 10.1109/icma.2019.8816393

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  • A Basic Study on Capacity and Reaction Time of Visual Working Memory for Elderly Memory Training

    Ting Guo, Yanna Ren, Yinghua Yu, Yiyang Yu, Yuuki Hasegawa, Qiong Wu, Jiajia Yang, Satoshi Takahashi, Yoshimichi Ejima, Jinglong Wu

    2019 IEEE International Conference on Mechatronics and Automation (ICMA)   2019年8月

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    掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:IEEE  

    DOI: 10.1109/icma.2019.8816525

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  • Layer-specific activation of sensory input and predictive feedback in the human primary somatosensory cortex. 国際誌

    Yinghua Yu, Laurentius Huber, Jiajia Yang, David C Jangraw, Daniel A Handwerker, Peter J Molfese, Gang Chen, Yoshimichi Ejima, Jinglong Wu, Peter A Bandettini

    Science advances   5 ( 5 )   eaav9053   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    When humans perceive a sensation, their brains integrate inputs from sensory receptors and process them based on their expectations. The mechanisms of this predictive coding in the human somatosensory system are not fully understood. We fill a basic gap in our understanding of the predictive processing of somatosensation by examining the layer-specific activity in sensory input and predictive feedback in the human primary somatosensory cortex (S1). We acquired submillimeter functional magnetic resonance imaging data at 7T (n = 10) during a task of perceived, predictable, and unpredictable touching sequences. We demonstrate that the sensory input from thalamic projects preferentially activates the middle layer, while the superficial and deep layers in S1 are more engaged for cortico-cortical predictive feedback input. These findings are pivotal to understanding the mechanisms of tactile prediction processing in the human somatosensory cortex.

    DOI: 10.1126/sciadv.aav9053

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  • Increased activity in superficial and deep layers of human S1 for prediction error

    Yinghua Yu, Laurentius Huber, Yuhui Chai, David C Jangraw, Arman Khojandi, Jiajia Yang, Peter A Bandettini

    Proc. Intl. Soc. Mag. Reson. Med   27   0613   2019年5月

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  • High-resolution fMRI maps of columnar organization in human primary somatosensory cortex

    Jiajia Yang, Laurentius Huber, Yinghua Yu, Yuhui Chai, Arman Khojandi, Peter A Bandettini

    Proc. Intl. Soc. Mag. Reson. Med   27   0617   2019年5月

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  • Depth-dependent functional mapping of mental prediction in human somatosensory cortex

    Yinghua Yu, Laurentius Huber, David C Jangraw, Peter J Molfese, Andrew Hall, Daniel A Handwerker, Jiajia Yang, Peter A Bandettini

    Proc. Intl. Soc. Mag. Reson. Med   26   393   2018年5月

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  • Asymmetric functional connectivity of the contra- and ipsilateral secondary somatosensory cortex during tactile object recognition 査読

    Yinghua Yu, Jiajia Yang, Yoshimichi Ejima, Hidenao Fukuyama, Jinglong Wu

    Frontiers in Human Neuroscience   11   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Frontiers Media S. A  

    In the somatosensory system, it is well known that the bilateral secondary somatosensory cortex (SII) receives projections from the unilateral primary somatosensory cortex (SI), and the SII, in turn, sends feedback projections to SI. Most neuroimaging studies have clearly shown bilateral SII activation using only unilateral stimulation for both anatomical and functional connectivity across SII subregions. However, no study has unveiled differences in the functional connectivity of the contra-and ipsilateral SII network that relates to frontoparietal areas during tactile object recognition. Therefore, we used event-related functional magnetic resonance imaging (fMRI) and a delayed match-to-sample (DMS) task to investigate the contributions of bilateral SII during tactile object recognition. In the fMRI experiment, 14 healthy subjects were presented with tactile angle stimuli on their right index finger and asked to encode three sample stimuli during the encoding phase and one test stimulus during the recognition phase. Then, the subjects indicated whether the angle of test stimulus was presented during the encoding phase. The results showed that contralateral (left) SII activity was greater than ipsilateral (right) SII activity during the encoding phase, but there was no difference during the recognition phase. A subsequent psycho-physiological interaction (PPI) analysis revealed distinct connectivity from the contra- and ipsilateral SII to other regions. The left SII functionally connected to the left SI and right primary and premotor cortex, while the right SII functionally connected to the left posterior parietal cortex (PPC). Our findings suggest that in situations involving unilateral tactile object recognition, contra- and ipsilateral SII will induce an asymmetrical functional connectivity to other brain areas, which may occur by the hand contralateral effect of SII.

    DOI: 10.3389/fnhum.2017.00662

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  • Current Screening Tests and Novel Early Detection Approaches for Alzheimer's Disease

    Mohd Usairy Syafiq, Jiajia Yang, Yinghua Yu, Jinglong Wu

    Neuroscience and Biomedical Engineering   5 ( 2 )   2018年1月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Bentham Science Publishers Ltd.  

    DOI: 10.2174/2213385205666170724143429

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  • Bigger Influence by Smaller Particles in Tactile-Visual Cross-Modal Roughness Perception of Fine Surface

    Mohd Usairy Syafiq, Jiajia Yang, Yinghua Yu, Jinglong Wu

    Neuroscience and Biomedical Engineering   5 ( 2 )   2018年1月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Bentham Science Publishers Ltd.  

    DOI: 10.2174/2213385205666170801151630

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  • Brain networks involved in tactile speed classification of moving dot patterns: the effects of speed and dot periodicity. 査読 国際誌

    Jiajia Yang, Ryo Kitada, Takanori Kochiyama, Yinghua Yu, Kai Makita, Yuta Araki, Jinglong Wu, Norihiro Sadato

    Scientific reports   7   40931 - 40931   2017年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NATURE PUBLISHING GROUP  

    Humans are able to judge the speed of an object's motion by touch. Research has suggested that tactile judgment of speed is influenced by physical properties of the moving object, though the neural mechanisms underlying this process remain poorly understood. In the present study, functional magnetic resonance imaging was used to investigate brain networks that may be involved in tactile speed classification and how such networks may be affected by an object's texture. Participants were asked to classify the speed of 2-D raised dot patterns passing under their right middle finger. Activity in the parietal operculum, insula, and inferior and superior frontal gyri was positively related to the motion speed of dot patterns. Activity in the postcentral gyrus and superior parietal lobule was sensitive to dot periodicity. Psycho-physiological interaction (PPI) analysis revealed that dot periodicity modulated functional connectivity between the parietal operculum (related to speed) and postcentral gyrus (related to dot periodicity). These results suggest that texture-sensitive activity in the primary somatosensory cortex and superior parietal lobule influences brain networks associated with tactually-extracted motion speed. Such effects may be related to the influence of surface texture on tactile speed judgment.

    DOI: 10.1038/srep40931

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  • Interactions Between Haptic and Visual Perceptions of Fine Surface Texture

    Yinghua Yu, Jiajia Yang, Hiroki Matsumoto, Jinglong Wu

    Neuroscience and Biomedical Engineering   4 ( 2 )   113 - 119   2016年8月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Bentham Science Publishers Ltd.  

    DOI: 10.2174/2213385204666160503161135

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  • Development and Evaluation of a Tactile Cognitive Function Test Device for Alzheimer’s Disease Early Detection

    Jiajia Yang, Mohd Usairy Syafiq, Yinghua Yu, Satoshi Takahashi, Zhenxin Zhang, Jinglong Wu

    Neuroscience and Biomedical Engineering   3 ( 2 )   58 - 65   2015年11月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Bentham Science Publishers Ltd.  

    DOI: 10.2174/2213385203666150804001349

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  • Speed Matching Interaction between Visual and Tactile Motion

    Liancun Zhang, Jiajia Yang, Yinghua Yu, Satoshi Takahashi, Yuta Araki, Qiang Huang, Jinglong Wu

    Neuroscience and Biomedical Engineering   3 ( 1 )   20 - 26   2015年8月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Bentham Science Publishers Ltd.  

    DOI: 10.2174/2213385203666150703164036

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  • Tactile priming modulates the activation of the fronto-parietal circuit during tactile angle match and non-match processing: an fMRI study 査読

    Jiajia Yang, Yinghua Yu, Akinori Kunita, Qiang Huang, Jinglong Wu, Nobukatsu Sawamoto, Hidenao Fukuyama

    FRONTIERS IN HUMAN NEUROSCIENCE   8   2014年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:FRONTIERS MEDIA SA  

    The repetition of a stimulus task reduces the neural activity within certain cortical regions responsible for working memory (WM) processing. Although previous evidence has shown that repeated vibrotactile stimuli reduce the activation in the ventrolateral prefrontal cortex, whether the repeated tactile spatial stimuli triggered the priming effect correlated with the same cortical region remains unclear. Therefore, we used event-related functional magnetic resonance imaging (fMRI) and a delayed match-to-sample task to investigate the contributions of the priming effect to tactile spatial WM processing. Fourteen healthy volunteers were asked to encode three tactile angle stimuli during the encoding phase and one tactile angle stimulus during the recognition phase. Then, they answered whether the last angle stimulus was presented during the encoding phase. As expected, both the Match and Non-Match tasks activated a similar cerebral network. The critical new finding was decreased brain activity in the left inferior frontal gyrus (IFG), the right posterior parietal cortex (PPC) and bilateral medial frontal gym (mFG) for the match task compared to the Non-Match task. Therefore, we suggest that the tactile priming engaged repetition suppression mechanisms during tactile angle matching, and this process decreased the activation of the fronto-parietal circuit, including IFG, mFG and PPC.

    DOI: 10.3389/fnhum.2014.00926

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  • Elevated audiovisual temporal interaction in patients with migraine without aura 査読

    Weiping Yang, Bingqian Chu, Jiajia Yang, Yinghua Yu, Jinglong Wu, Shengyuan Yu

    JOURNAL OF HEADACHE AND PAIN   15   2014年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER-VERLAG ITALIA SRL  

    Photophobia and phonophobia are the most prominent symptoms in patients with migraine without aura. Hypersensitivity to visual stimuli can lead to greater hypersensitivity to auditory stimuli, which suggests that the interaction between visual and auditory stimuli may play an important role in the pathogenesis of migraine. However, audiovisual temporal interactions in migraine have not been well studied. Therefore, our aim was to examine auditory and visual interactions in migraine.
    In this study, visual, auditory, and audiovisual stimuli with different temporal intervals between the visual and auditory stimuli were randomly presented to the left or right hemispace. During this time, the participants were asked to respond promptly to target stimuli. We used cumulative distribution functions to analyze the response times as a measure of audiovisual integration.
    Our results showed that audiovisual integration was significantly elevated in the migraineurs compared with the normal controls (p < 0.05); however, audiovisual suppression was weaker in the migraineurs compared with the normal controls (p < 0.05).
    Our findings further objectively support the notion that migraineurs without aura are hypersensitive to external visual and auditory stimuli. Our study offers a new quantitative and objective method to evaluate hypersensitivity to audio-visual stimuli in patients with migraine.

    DOI: 10.1186/1129-2377-15-44

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  • Ability to Recognize and Identify the Location of Vibration Stimulation on the Fingers 査読

    Yang Liu, Yinghua Yu, Jiajia Yang, Yoshinobu Inai, Jinglong Wu

    2014 IEEE INTERNATIONAL CONFERENCE ON MECHATRONICS AND AUTOMATION (IEEE ICMA 2014)   1601 - 1606   2014年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:IEEE  

    To investigate the tactile numerosity judgments and position report by simultaneously presenting, we asked human subjects to answer the number and the location of eight vibrations presented to different fingertips on right hand. In numerosity judgments task, we found that the accuracy of participants' responses decreased as the number of stimuli activated was increased. And as the more stimulus presentation, the answer is smaller than the correct answer. In position report task, we found that index finger has higher accuracy of vibrotactile discrimination than the other fingers. Moreover, the sensitivity of distal phalanx part is higher than middle phalanx.

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  • Development of a magnetic resonance-compatible tactile orientation delivery system 査読

    Di Chen, Jiajia Yang, Yinghua Yu, Ryousuke Goto, Satoshi Takahashi, Jinglong Wu

    2014 IEEE INTERNATIONAL CONFERENCE ON MECHATRONICS AND AUTOMATION (IEEE ICMA 2014)   879 - 883   2014年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:IEEE  

    Working memory are closely related to everyday cognition (such as remembering the conversation and characters). Studies with hearing, vision stimulation have always been carried out, but studies using tactile stimulation are very little. However, tactile working memory is the ability to reproduce the functionality of the somatosensory system. It is very relevant to elucidation of the somatosensory system and intellectual impairment of tactile. Moreover, Visual and Auditory task have possibilities affect education and living environment, such as number, language and so on. On the other hand, tactile stimulation task can research human cognition without the problem. However, tactile stimulation is presented by hand, so study of tactile working memory does not consider pressure information and influence result. Moreover, Active region of brain is changed from time to time in working memory, it must be considered too. Memory in order to investigate the tactile working memory, device for considering the pressure information and to present the tactile stimulation on constant conditions is indispensable. In this Study, we developed and evaluated a device for tactile spatial research in high magnetic field environment. Consideration to advanced research on fMRI environment in the future, we developed device in High magnetic field environment.

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  • MRI-compatible tactile orientation stimulator to investigate neural mechanisms of tactile orientation discrimination

    Yinghua Yu, Jiajia Yang, HongZan Sun, Qiyong Guo, Jinglong Wu

    Information (Japan)   17 ( 6 A )   2463 - 2472   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:International Information Institute Ltd.  

    Functional magnetic resonance imaging (fMRI) is one of the most recently developed forms of neuro imaging, uses MRI to measure the haemodynamic response related to neural activity. In this study, we developed a tactile orientation system using under high magnetic environment. The device is MRI-compatible and can serve to investigate the underlying neural mechanisms of tactile orientation discrimination. The primary components of the tactile orientation presentation system include a computer, five tactile orientation domes, two ultrasonic motors, a motor controller and a reaction key. We evaluated the function and precision of system in a magnetic field. The results showed that the device performance is unaffected by the magnetic field, nor does the device interfere with the magnetic field, making it usable with fMRI. Furthermore, a tactile orientation discrimination fMRI experiment was conducted using the system. Compared to the baseline, the most prominent activation areas evoked by the discrimination tasks were in the bilateral primary and secondary somatosensory area, medial frontal gyrus, posterior parietal cortex and lateral occipital complex. In summary, these results indicated that the brain activation can be reliably detected with the present device. © 2014 International Information Institute.

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  • Limited Persistence of Tactile Working Memory Resources During Delay- Dependent Grating Orientation Discrimination

    Yinghua Yu, Jiajia Yang, Jinglong Wu

    Neuroscience and Biomedical Engineering   1 ( 1 )   65 - 72   2013年5月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Bentham Science Publishers Ltd.  

    DOI: 10.2174/2213385211301010011

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  • 視覚誘導自己直線運動感覚の空間特性の輝度依存性

    呉 景龍, 于 英花, 楊 家家

    人間工学 = The Japanese journal of ergonomics   49 ( 1 )   18 - 24   2013年2月

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    記述言語:日本語   出版者・発行元:Japan Ergonomics Society  

    人間の視野に,一定条件の運動視覚情報を与えることによって,身体が静止状態であるにもかかわらず,自己運動感覚を引き起こすことがある.このことを視覚誘導自己運動感覚と言う.視覚誘導自己運動感覚(Vection)は自己運動感覚の方向によって,大きく二種類に分けられ,視覚誘導自己直線運動感覚(LV:Linear Vection)と視覚誘導自己回転運動感覚(CV:Circular Vection)がある.Vectionの誘導メカニズムを解明するには,時空間周波数と視野などの視覚刺激パラメータの依存性がよく研究されたが,Vectionの輝度依存性はまだ解明されていない.本研究では,大型平面液晶ディスプレイを用いて,LVの空間特性の輝度依存性について検討を行った.その結果,LVは視覚刺激の中心視野の平均輝度変化に有意差が見られ,周辺視野の輝度変化に依存しないことがわかった.

    DOI: 10.5100/jje.49.18

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    その他リンク: https://jlc.jst.go.jp/DN/JALC/10015737372?from=CiNii

  • Development and evaluation of vibrotactile stimuli presentation device to investigate tactile working memory 査読

    Yang Liu, Jiajia Yang, Yinghua Yu, Yoshinobu Inai, Jinglong Wu

    2013 IEEE International Conference on Mechatronics and Automation, IEEE ICMA 2013   135 - 140   2013年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)  

    Human have five senses which are visual, auditory, smell, touch and taste. The sense of touch is occurring when the skin contact with any object and human can percept the shape, temperature, vibration of the object. As well known, the spatial density of receptors located in the human skin differed of different parts such as index finger. Therefore, the sensitivity of each finger were differed from each other. In the present study, we developed a novel automatic vibrotactile patterns delivery device that is capable of perform the tactile cognitive experiment. It can serve to determining the sensitivity of each finger that contributes to tactile spatial discrimination. The primary device consists of eight piezo-electric units, slider, hand support and a controller. The device is controlled by a computer. To evaluate the performance of the device, we conducted a basic function test. The results indicated that the device can record reliable data and control the tactile pattern position precisely. Finally, ten young subjects consented to participate in the position discrimination tasks. The subjects were asked to detect the tactile stimuli and report the location. We found that index finger has higher accuracy of vibrotactile discrimination than the other fingers. Moreover, the sensitivity of distal phalanx part is higher than middle phalanx. © 2013 IEEE.

    DOI: 10.1109/ICMA.2013.6617906

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  • Development of a Tactile Angle Stimuli Presentation Device for Tactile Cognitive Function Discrimination 査読

    Mohd Usairy Syafiq, Yu Yinghua, Jiajia Yang, Jinglong Wu

    2013 IEEE INTERNATIONAL CONFERENCE ON MECHATRONICS AND AUTOMATION (ICMA)   116 - 121   2013年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:IEEE  

    We have developed a novel automated device for assessing and training cognitive function on tactile senses. The device is capable of investigating tactile pattern discrimination. Tactile patterns are fixed to a conveyor belt and presented continuously to the subject. We used two gears to convert power from a stepping motor into a rotary movement of the belt. 16 different types of angle patterns can be presented in one diagnosis. Development of the device was intended to support our previous study about deficits in tactile discrimination because of aging and cognition disease, suggesting that the device provides a bright future for investigating cognitive function of touch discrimination. Expectantly, the device will be the medium to enable the future application for early diagnosis of dementia.

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  • Neuropsychological Parameters as Potential Biomarkers for Alzheimer’s Disease

    Jinglong Wu, Yinghua Yu, Jiajia Yang

    Current Translational Geriatrics and Experimental Gerontology Reports   1 ( 2 )   68 - 75   2012年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1007/s13670-012-0007-4

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    その他リンク: http://link.springer.com/article/10.1007/s13670-012-0007-4/fulltext.html

  • Neural correlates of tactile orientation discrimination: An fMRI study 査読

    Yinghua Yu, Jiajia Yang, Jinglong Wu, Qiyong Guo

    2012 ICME International Conference on Complex Medical Engineering, CME 2012 Proceedings   713 - 716   2012年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)  

    In the present study, using event-related functional magnetic resonance imaging (fMRI) we measured the tactile memory related brain activations with tactile orientation discrimination task. For each trial, two of three tactile grating domes with same or different orientations (0, 45 and 90° against the proximal-distal line of right index finger) were presented to the subjects' right index fingertip. Nine health young subjects were asked to discriminate whether the orientations of two tactile stimuli was the same or not. Compared to the resting period, the most prominent activation areas evoked by the orientation discrimination tasks were in the primary and secondary somatosensory areas in the bilateral parietal operculum (SI and SII), posterior parietal cortex (PPC), prefrontal cortex (PFC), supplementary motor area (SMA), lateral occipital complex (LOC), insula and cerebellum. But we found that both of the activation in intensity and size were higher during tactile orientation discrimination process compared to these of encoding process. The result suggested that the tactile orientation discrimination process may raise more brain activations since this process include the high level processing such as recall and decision making. © 2012 IEEE.

    DOI: 10.1109/ICCME.2012.6275749

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  • Development and evaluation of a tactile speed stimulator for MRI environment 査読

    Min Guo, Yinghua Yu, Araki Yuta, Jiajia Yang, Jinglong Wu

    2012 ICME International Conference on Complex Medical Engineering, CME 2012 Proceedings   673 - 676   2012年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)  

    Functional magnetic resonance imaging (fMRI), one of the most popular forms of neuroimaging, uses MRI to measure the hemodynamic response related to neural activity. In the present study, we developed a tactile speed stimulator for fMRI environment. The device is MRI-compatible and can serve to investigate the underlying neural mechanisms of tactile speed discrimination. The primary components of the tactile speed stimulator system include a computer, two drums with dots, a motor controller and a reaction key. We evaluated the function, precision and performance of the system in a magnetic field. The results showed that the device performance is unaffected by the magnetic field, nor does the device interfere with the magnetic field, making it usable with fMRI. Furthermore, a simple pressing button in fMRI experiment was conducted using the system. Compared to the baseline, the most prominent activation areas evoked by the button press task were in the lobulus parietalis inferior, gyrus postcentralis, gyrus frontalis inferior and gyrus precentralis.In conclusion, these results indicated that the brain activation can be reliably detected with the present device. © 2012 IEEE.

    DOI: 10.1109/ICCME.2012.6275623

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  • Delayed Audiovisual Integration of Patients with Mild Cognitive Impairment and Alzheimer's Disease Compared with Normal Aged Controls 査読

    Jinglong Wu, Jiajia Yang, Yinghua Yu, Qi Li, Naoya Nakamura, Yong Shen, Yasuyuki Ohta, Shengyuan Yu, Koji Abe

    JOURNAL OF ALZHEIMERS DISEASE   32 ( 2 )   317 - 328   2012年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IOS PRESS  

    The human brain can anatomically combine task-relevant information from different sensory pathways to form a unified perception; this process is called multisensory integration. The aim of the present study was to test whether the multisensory integration abilities of patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) differed from those of normal aged controls (NC). A total of 64 subjects were divided into three groups: NC individuals (n = 24), MCI patients (n = 19), and probable AD patients (n = 21). All of the subjects were asked to perform three separate audiovisual integration tasks and were instructed to press the response key associated with the auditory, visual, or audiovisual stimuli in the three tasks. The accuracy and response time (RT) of each task were measured, and the RTs were analyzed using cumulative distribution functions to observe the audiovisual integration. Our results suggest that the mean RT of patients with AD was significantly longer than those of patients with MCI and NC individuals. Interestingly, we found that patients with both MCI and AD exhibited adequate audiovisual integration, and a greater peak (time bin with the highest percentage of benefit) and broader temporal window (time duration of benefit) of multisensory enhancement were observed. However, the onset time and peak benefit of audiovisual integration in MCI and AD patients occurred significantly later than did those of the NC. This finding indicates that the cognitive functional deficits of patients with MCI and AD contribute to the differences in performance enhancements of audiovisual integration compared with NC.

    DOI: 10.3233/JAD-2012-111070

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  • P1‐492: Early detection of patients with mild cognitive impairment and Alzheimer's disease using a novel tactile approach

    Jiajia Yang, Yinghua Yu, Yong Shen, Yasuyuki Ohta, Koji Abe, Jinglong Wu

    Alzheimer's & Dementia   7 ( 4S_Part_8 )   2011年7月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1016/j.jalz.2011.05.774

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  • Development and evaluation of a MRI-compatible tactile orientation stimulator 査読

    Yinghua Yu, Jiajia Yang, Jinglong Wu, Hongzan Sun, Qiyong Guo

    2011 IEEE/ICME International Conference on Complex Medical Engineering, CME 2011   526 - 531   2011年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)  

    Functional magnetic resonance imaging (fMRI) is one of the most recently developed forms of neuroimaging, uses MRI to measure the haemodynamic response related to neural activity. In the present study, we developed a tactile orientation stimulator using under high magnetic environment. The device is MRI-compatible and can serve to investigate the underlying neural mechanisms of tactile orientation cognition and discrimination. The primary components of the tactile orientation presentation system include a computer (system control), seven tactile orientation domes, two ultrasonic motors (tactile stimuli presentation), a motor controller and a reaction key. We evaluated the function, precision and performance of the system in a magnetic field. The results showed that the device performance is unaffected by the magnetic field, nor does the device interfere with the magnetic field, making it usable with fMRI. Furthermore, a simple button press fMRI experiment was conducted using the system. Compared to the baseline, the most prominent activation areas evoked by the button press task were in the primary motor area on the right precentral gyrus, bilateral medial frontal gyrus, putamen and cerebellum. In summary, these results indicated that the brain activation can be reliably detected with the present device. © 2011 IEEE.

    DOI: 10.1109/ICCME.2011.5876797

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  • Perception of linear self motion under different visual contrast conditions for development of driving simulator

    Yinghua Yu, Jinglong Wu

    IEEE/ICME International Conference on Complex Medical Engineering   2010年7月

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    掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:IEEE  

    DOI: 10.1109/iccme.2010.5558862

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  • Luminance effects on visual perception of self-rotation for development of driving simulator

    Yinghua Yu, Jinglong Wu

    PROCEEDINGS OF SICE ANNUAL CONFERENCE, VOLS 1-8   2844 - +   2007年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:IEEE  

    Large-field visual stimulation with a rotating stimulus often induces the illusion of self-rotation, which is called circular vection (CV). Although CV has been extensively studied, the dependence of CV on the spatial frequency, luminance and visual-field of the visual stimulus remains unclear. In this paper, we investigated the luminance effects on visual perception of self-rotation. Fourteen young adult male volunteer subjects participated in the study. The device comprised a wide-view screen, a PC and a reaction key. The experimental stimuli were generated onto screen by PC. The sine-wave stimulus was rotated, and changed into five spatial frequencies (0.033, 0.053, 0.084, 0.130, and 0.210 cycle/deg) and six luminance conditions. The subjects reported the perceived CV velocity using the magnitude estimation method, and the latency of CV was defined as the time from the start of the stimulus to the onset of CV. These results may suggested that the CV to be more compelling when the spatial frequency from 0.053cycle/deg to 0.084 cycle/deg and high luminance of visual stimuli in central vision field. And the CV to be faster induced when the spatial frequency approximately 0.084 cycle/deg and high luminance of visual stimuli in central vision field.

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▼全件表示

MISC

共同研究・競争的資金等の研究

  • 顕在と潜在の意図推定による選択意図の脳内メカニズムの解明と意図理解ロボットの提案

    研究課題/領域番号:22K04011  2022年04月 - 2026年03月

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    呉 瓊, 高橋 智, 呉 景龍, 江島 義道, 于 英花

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    配分額:4030000円 ( 直接経費:3100000円 、 間接経費:930000円 )

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  • 7テスラfMRIによる触覚知覚を司る大脳皮質層別の情報処理機構の解明

    研究課題/領域番号:22K07327  2022年04月 - 2025年03月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    于 英花

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    配分額:4290000円 ( 直接経費:3300000円 、 間接経費:990000円 )

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  • 手触り感覚脳内モデルの同定と形状・質感を知覚できるロボットハンドへの適用

    研究課題/領域番号:18K18835  2018年06月 - 2021年03月

    日本学術振興会  科学研究費助成事業 挑戦的研究(萌芽)  挑戦的研究(萌芽)

    呉 景龍, 高橋 智, 金澤 右, 楊 家家, 呉 瓊, 江島 義道, 于 英花

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    配分額:6240000円 ( 直接経費:4800000円 、 間接経費:1440000円 )

    本研究では,まず、fMRI高磁場環境で使用できる条件を満たすため、使用材料は非磁気のプラスチック素材を選び、駆動方式は空気圧制御を採用した。それから、掌サイズと凹凸の個人差を考慮して、上下と左右をミリ単位で微調整可能かつ高空間分解度(㎜)の力学刺激を提示できる触覚実験装置を研究開発した。手触り感覚、形状・質感脳内モデルを同定できる実験タスクを考案するため、最新の研究成果を調査して大域と小域を複合した新しい触覚実験タスクを提案した。
    手触り感覚脳内モデルの同定を実現するため、触覚認知の工学実験とfMRI実験を設計した。さらに、掌の(x, y)平面の各部位を、独自に研究開発して触覚実験専用デバイスを使用して時空間ダブル循環方式で掌の各部位を刺激して、脳内皮質平面(u, v)における脳活動信号を計測するfMRI予備実験を実施している。
    得られた実験データはSPMなどの通用解析方法の以外に独自提案した方法も用いて解析している。手触り感覚脳内モデルの同定は、最先端の研究成果を調査収集した上、本研究の成果に基づいて検討している。
    これらの成果は学術雑誌論文5件(Frontiers in human neuroscience 1件, Parkinson's Disease 1件, Information 2件, International journal of psychophysiology 1件)掲載されている。関連成果はIEEE、ICMEなどの国際会議と国内の関連学会でも6件を発表された。

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  • ヒトの体性感覚皮質3b野における皮膚感覚受容野のコラム構造の解明

    研究課題/領域番号:18K15339  2018年04月 - 2022年03月

    日本学術振興会  科学研究費助成事業 若手研究  若手研究

    于 英花

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    配分額:4030000円 ( 直接経費:3100000円 、 間接経費:930000円 )

    ものに触れたときに得られる皮膚感覚情報は,脊椎や視床などを経由して大脳皮質の中心後回にある体性感覚皮質3b野に到達することは,脳機能イメージング研究で明らかにされている。また,サルを用いた研究により,皮膚内部にある2種類の皮膚感覚受容器(SAとRA)に対応する皮膚感覚受容野がコラム構造をなすことが示されたが,ヒトの3b野において同様なコラム構造をなすかは未だ解明されていない。本研究の全体目標は,超高磁場機能的磁気共鳴画像法(7T-fMRI)を用いてヒトの3b野におけるSAとRA受容野のコラム構造を解明することである。
    前記の目標達成に向けて,初年度では当初計画していったSAとRA受容器を選択的に刺激できる触覚刺激と刺激法の選定が行った。これまでの知見により,SAとRA受容器は皮膚と対象の接触で得られた時間的・空間的情報に対して異なる応答特性を示すことがわかった。具体的に,圧覚刺激の場合,RA受容器はトランジェントの発火を示しているに対して,SA受容器は刺激期間中に持続的に発火している。一方,振動刺激の振幅が一定で振動周波数の増大に従ってRA受容器の発火強度が強くなるが,SA受容器は一定で小さい。サルを用いた研究の場合は,3b野に電極を刺し,指先に2秒間の圧覚刺激を提示するだけでSAとRA受容野の異なる活動パタンを検出できたが,fMRI技術の性質上の制限により,前述のSAとRA発火特性を利用した手法はヒトのfMRI研究に適用できない。そのため,今年度では,数種類の触覚刺激を用いた刺激選定fMRI実験を実施した。その中から粗さが異なる凸状ドットパターン刺激と,独自で考案した実験パラダイムはSAとRA受容野のコラム構造の同定できる可能性が高いことがわかった。この触覚刺激と実験パラダイムの選定は本研究随行に必要不可欠であり,次年度の研究実施に大きく貢献している。

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  • 記憶・想起の脳機能ネットワークの解明と認知症早期治療システムの構築

    研究課題/領域番号:18H01411  2018年04月 - 2022年03月

    日本学術振興会  科学研究費助成事業 基盤研究(B)  基盤研究(B)

    呉 景龍, 大谷 芳夫, 阿部 康二, 高橋 智, 美馬 達哉, 楊 家家, 呉 瓊, 于 英花, 江島 義道

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    配分額:17030000円 ( 直接経費:13100000円 、 間接経費:3930000円 )

    本年度では、まず、脳機能解明の装置とタスクの従来研究開発の経験を活かして、fMRI高磁場環境で視覚・聴覚・触覚の多感覚による短期記憶と想起の実験・訓練タスクを提示できる脳機能研究の専用実験装置を研究開発した。特に、触覚刺激装置については、高磁場環境を考慮して非磁気素材を選定し、空気圧制御による力学を提示できる実験装置を製作した。視覚・聴覚・触覚のマルチ刺激の併用による記憶機能を増進できる実験・訓練タスクの考案については、最新関連研究を調査した上、視覚と触覚との共通性を有する空間パターンの短期記憶タスクを新に提案した。次に、脳機能ネットワークと記憶脳機能の従来研究成果を活かして視覚・聴覚・触覚の同時刺激及び脳波とfMRIの時空間計測という複眼的観点から記憶・想起脳機能実験を設計し、代表者の研究室と共同研究先の病院で関連実験を実施した。得られた実験データに基づいて独自に開発した多感覚モダリティ・マルチメディア解析、ディープラーニングなどの機械学習手法を用いて実験データの統合処理を通じて、短期記憶と想起の脳機能ネットワークを検討している。さらに、空間パターンの短期記憶・想起の脳機能ネットワークの知見に基づいて、想起による短期記憶能力を回復する認知症早期治療モデルを検討している。得られた研究成果はFrontiers in human neuroscience, Parkinson's Disease, Information, International Journal of Psychophysiologyなどの国際雑誌に掲載されている。研究成果はIEEE,ICMEなどの関連学術会議でも発表された。

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  • ミクロンの表面凹凸の違いを指先で感じ取る「匠の技」の脳科学的解明

    研究課題/領域番号:17K18855  2017年06月 - 2020年03月

    日本学術振興会  科学研究費助成事業 挑戦的研究(萌芽)  挑戦的研究(萌芽)

    楊 家家, 呉 景龍, 山本 洋紀, 高橋 智, 呉 瓊, 于 英花

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    配分額:6370000円 ( 直接経費:4900000円 、 間接経費:1470000円 )

    ヒトは,わずか数ミクロンの凹凸でも指先で触れるだけで凹凸判断ができる能力を備えている。多くの自動車メーカーの工場では,熟練の技術者が経験で磨いた「匠の技」を利用して,車体表面を撫でることで数ミクロンの突起を検出し,品質検査を行っている。しかし,車体表面は塗料でコーティングされているため,この「匠の技」を既存の光学系計測システムに置き換えることができないのが現状である。一方,このような熟練の技術者は,「どのようにしてミクロンオーダーの凹凸を指先で検知しているのか?」,「脳内でどのような情報処理して接触面の違いを判断できるのか?」の疑問の未解明が,「匠の技」を工学的技術に置き換えることができない主な要因である。本研究は,上記の疑問に対する解答を得て,「匠の技」を工学的技術に置き換える方策を提案することを目的である。
    今年度は,前年度で試作した2次元レーザ測定ユニットを用いた指紋微振動直接観察システムの原案を見直し,新たにシステムの研究開発に取り込んできた。具体的に,前年度で試作した2次元レーザ測定ユニットを用いた場合は,静止の指紋三次元構成の計測ができるが,微小振動の検出時にノイズが多かったため,測定不能の問題点があった。今年度は,まず高速度カメラによる計測方式へ変更し,システム全体構成を改良した。次に,触覚凹凸縞模様パターンの凹凸幅を変化させて(0.1mm, 0.2mm, 0.5mm, 0.7mmと1.0mmの5種類),システムの評価実験を行った。その結果,新システムの撮像ノイズ低減が顕著であり,5種類の刺激中0.5mm以上の3種類において,刺激時の指紋微小振動の計測に成功した。さらに,課題である凹凸幅0.1mmと0.2mmの縞模様を用いた場合の指紋微小振動の計測は,解決策案も出来ている。

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  • 視触覚のクロスモーダルな質感認知の脳機能解明と高質感の表面加工への適用

    研究課題/領域番号:17J40084  2017年04月 - 2020年03月

    日本学術振興会  科学研究費助成事業 特別研究員奨励費  特別研究員奨励費

    于 英花

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    配分額:4420000円 ( 直接経費:3400000円 、 間接経費:1020000円 )

    「高質感」のものづくりは21世紀の日本産業に強く求められている。しかし,製品質感の評価は職人の経験,見た目や手触りなどの主観的な判断に頼り,客観的な質感評価技術はまだ確立されていない。質感はヒトの視覚や触覚などの多感覚情報を脳内の統合処理で得られる複雑なものであり,質感の数値化・定量化ができないのは,質感認知の脳機能が未だ解明されていないためである。そのため,高質感製品の創出には,質感認知の脳機能を解明して,客観的な質感評価指標を作成することが重要である。本研究では,視覚と触覚のクロスモーダルな質感認知の脳内処理メカニズムを究明し,質感認知特性に基づいた高質感表面加工システムの研究開発及び試作を行うことを目的としている。
    本年度では,まず,前年度の成果に基づいて,視覚と触覚刺激を洗練して,視覚と触覚のクロスモーダルな質感認知に関するfMRI実験が実施した。さらに,PPI(Psycho-Physiologic Interaction)解析・拡散テンソル画像(DTI)解析を取り入れ,質感認知の脳内機能的・解剖的ネットワークを検討した。次に,脳情報デコーディング解析を適用し,質感認知の脳内処理の各階層と階層間の相互作用を検討し,質感データベースに必要な視触覚パラメータを検討した。さらに,本年度から最新の7テスラ高空間分解能fMRI装置の利用が可能となり,脳情報デコーディング解析の精度向上が期待できる。そのため,これまで予定している実験を行うと同時に,ヒトの第一次体性感覚野の各層の機能的違いの観察と各層間の相互作用の検討実験も設計・実施した。

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