Updated on 2025/06/26

写真a

 
HIGAKI Fumiyo
 
Organization
Scheduled update Assistant Professor
Position
Assistant Professor
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Degree

  • medical doctor ( 2010.3   Okayama University )

  • 博士（医学） ( 岡山大学 )

Professional Memberships

Committee Memberships

  •   日本核医学会 評議員  

       

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Papers

  • Potential for Radiation Dose Reduction in Temporal Bone CT Imaging Using Photon-Counting Detector CT.

    Fumiyo Higaki, Yusuke Morimitsu, Toshihiro Iguchi, Sung Il Hwang, Takahiro Kitayama, Yuka Takahashi, Mayu Uka, Noriaki Akagi, Akiko Sugaya, Toshiharu Mitsuhashi, Yusuke Matsui, Takao Hiraki

    Acta medica Okayama   79 ( 2 )   75 - 80   2025.4

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    Temporal bone computed tomography (CT) is frequently performed for pediatric patients with ear diseases. Advances in CT technology have improved diagnostic imaging quality, but reduction of radiation exposure remains a goal. We evaluated the potential for radiation dose reduction in temporal bone CT examinations using porcine ear ossicles and a photon-counting detector CT system. Three scans of the bilateral temporal bone were performed on each of three pig cadaver heads. In each of seven successive imaging sessions, the radiation dose was reduced by an additional one-seventh of the recommended dose (RD). Two board-certified radiologists independently scored the resulting images on a scale of 1 to 5 points, where 5 represented the image quality at the RD. Images scoring ≥4.5 points were considered acceptable. Noise was assessed in a 2-cm-diameter region near the ear ossicles, and standard deviation was measured for each of the seven decrements from the RD. As the radiation dose decreased, the noise progressively increased, and visual assessment scores progressively decreased. Acceptable image scores were obtained at six-sevenths (4.9), five-sevenths (4.8), four-sevenths (4.7), and three-sevenths (4.6) of the RD. Thus, acceptable porcine temporal bone CT images were obtained with a radiation dose reduction of approximately 50%.

    DOI： 10.18926/AMO/68645

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  • A Rare Case of Adult-onset Gangliocytoma in the Parietal Lobe: Case Report and Surveillance, Epidemiology, and End Results Registry Data Analysis.

    Ryosuke Ikemachi, Yusuke Tomita, Yoshihiro Otani, Joji Ishida, Kentaro Fujii, Fumiyo Higaki, Sawako Ono, Yonehiro Kanemura, Shota Tanaka

    NMC case report journal   12   153 - 158   2025

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    We report a case of adult-onset gangliocytoma in the parietal lobe. A 54-year-old woman presented with sensory disturbance in her right upper limb. A computed tomography scan revealed a cystic and calcified lesion in the left parietal lobe. She underwent a left parietal craniotomy with gross total resection, and the pathological diagnosis was confirmed as gangliocytoma. Gangliocytomas are very rare tumors of the central nervous system, predominantly affecting children and young adults, and are often located in the temporal lobe. Reports of gangliocytomas developing after middle age are uncommon. To assess the epidemiology of gangliocytoma, we utilized data from the Surveillance, Epidemiology, and End Results database. From January 1, 2000, to December 31, 2021, a total of 74 cases were identified, 18 of which were in patients over 50 years of age. While 27 patients had tumors in the temporal lobe, the most frequent site, others had tumors in different locations. Notably, there were no patients over 50 with gangliocytoma in the parietal lobe in the Surveillance, Epidemiology, and End Results registry. These findings suggest that in older patients, although gangliocytomas located outside the temporal lobe are rare, they are kept in mind as one of the differential diagnoses.

    DOI： 10.2176/jns-nmc.2024-0306

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  • Comparative analysis of intraoperative MRI and early postoperative MRI findings in glioma surgery patients. Reviewed International journal

    Yoshihiro Otani, Fumiyo Higaki, Kentaro Fujii, Joji Ishida, Yosuke Shimazu, Shuichiro Hirano, Naoya Kemmotsu, Yasuki Suruga, Ryoji Imoto, Ryo Mizuta, Yasuhito Kegoya, Yohei Inoue, Tsuyoshi Umeda, Madoka Hokama, Takao Yasuhara, Takao Hiraki, Kazuhiko Kurozumi, Tomotsugu Ichikawa, Shota Tanaka, Isao Date

    Journal of neurosurgery   1 - 9   2024.12

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    OBJECTIVE: The extent of resection (EOR) is an important prognostic factor for both low- and high-grade gliomas. Intraoperative MRI (iMRI) has been used to increase the EOR in glioma surgery. While a recent study reported differences between iMRI and early postoperative MRI (epMRI), their specific relationship to postoperative clinical symptoms remains unclear. This study aims to compare the differences between iMRI and epMRI in glioma surgery. METHODS: A retrospective assessment was conducted on 43 patients with glioma who underwent surgery with iMRI and for whom no additional resection was performed after iMRI. The study evaluated the discrepancies in EOR, surgically induced contrast enhancement (SICE), and diffusion-weighted imaging (DWI) abnormality between iMRI and epMRI. EOR was defined as gross-total resection (GTR), near-total resection, subtotal resection (STR), or partial resection (PR) for enhancing lesions, and GTR, STR, or PR for nonenhancing lesions. In addition, the relationship between postoperative neurological findings and iMRI findings was evaluated. RESULTS: Discrepancies in EOR were observed in 2 (11.1%) of 18 cases with nonenhanced lesions and 1 (4.0%) of 25 cases with enhanced lesions. The positive rate of SICE was 25.0% on iMRI and 67.9% on epMRI. Enhancement at the resection cavity was the most frequent pattern in both iMRI and epMRI. The positive rate of enhancement of the resection cavity was strongly increased on epMRI compared with iMRI, potentially mimicking residual tumor. The positive rate of DWI abnormality was 73% on iMRI and 89.2% on epMRI. Among the 10 patients who showed no DWI abnormality on iMRI, 6 exhibited DWI abnormality on epMRI (the late-developing group). Two patients developed new neurological deficits postoperatively, and both showed DWI abnormality on both iMRI and epMRI. No patient in the late-developing group developed postoperative neurological deficits. CONCLUSIONS: Overall, iMRI demonstrated more accurate EOR and less SICE compared with epMRI. Although the positive rate of DWI abnormality was lower on iMRI than on epMRI, the late-developing group showed no postoperative neurological deficits. Therefore, iMRI is more useful in assessing accurate EOR and detecting postoperative neurological deficits than epMRI.

    DOI： 10.3171/2024.7.JNS24784

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  • Cranial and spinal computed tomography (CT) angiography with photon-counting detector CT: comparison with angiographic and operative findings. Reviewed

    Fumiyo Higaki, Masafumi Hiramatsu, Takao Yasuhara, Susumu Sasada, Yoshihiro Otani, Jun Haruma, Tomohiro Inoue, Yusuke Morimitsu, Noriaki Akagi, Yusuke Matsui, Toshihiro Iguchi, Takao Hiraki

    Japanese journal of radiology   2024.9

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    The clinical imaging features of photon-counting detector (PCD) computed tomography (CT) are mainly known as dose reduction, improvement of spatial resolution, and reduction of artifacts compared to energy-integrating detector CT (EID-CT). The utility of cranial and spinal PCD-CT and PCD-CT angiography (CTA) has been previously reported. CTA is a widely used technique for noninvasive evaluation. Cranial CTA is important in brain tumors, especially glioblastoma; it evaluates whether the tumor is highly vascularized prior to an operation and helps in the diagnosis and assessment of bleeding risk. Spinal CTA has an important role in the estimation of feeders and drainers prior to selective angiography in the cases of spinal epidural arteriovenous fistulas and spinal tumors, especially in hemangioblastoma. So far, EID-CTA is commonly performed in an adjunctive role prior to selective angiography; PCD-CTA with high spatial resolution can be an alternative to selective angiography. In the cases of cerebral aneurysms, flow diverters are important tools for the treatment of intracranial aneurysms, and postoperative evaluation with cone beam CT with angiography using diluted contrast media is performed to evaluate stent adhesion and in-stent thrombosis. If CTA can replace selective angiography, it will be less invasive for the patient. In this review, we present representative cases with PCD-CT. We also show how well the cranial and spinal PCD-CTA approaches the accuracy of angiographic and intraoperative findings.

    DOI： 10.1007/s11604-024-01661-w

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  • Remission of hypersensitivity pneumonitis after allogeneic hematopoietic stem cell transplantation. Reviewed International journal

    Yumi Inukai Motokura, Hisao Higo, Chiaki Matsumoto, Mari Uno, Kanako Fujiwara, Toshiki Terao, Satoko Makimoto, Fumiyo Higaki, Ken-Ichi Matsuoka, Fumiaki Tokioka, Yoshinobu Maeda, Nobuaki Miyahara

    Respiratory investigation   62 ( 5 )   759 - 761   2024.7

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    A 50-year-old man was diagnosed with hypersensitivity pneumonitis caused by the environment of his bar owing to worsening symptoms, laboratory test results, and computed tomography images after an environmental inhalation challenge test. His hypersensitivity pneumonitis exacerbated despite receiving prednisolone 20 mg/day. The patient underwent allogeneic hematopoietic stem cell transplantation (HSCT) from a human leukocyte antigen-matched unrelated donor for myelodysplastic syndrome. No exacerbation of hypersensitivity pneumonitis was observed after HSCT. An environmental inhalation challenge test involving exposure to his bar confirmed the remission of hypersensitivity pneumonitis after HSCT. This case demonstrates that hypersensitivity pneumonitis can be remitted by HSCT.

    DOI： 10.1016/j.resinv.2024.06.007

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  • Photon-Counting Detector CT: Potential for 75% Reduction in Contrast Medium Amount: A Phantom Study. Reviewed

    Fumiyo Higaki, Yusuke Morimitsu, Toshihiro Iguchi, Hayato Saito, Haruhiko Takaki, Ayako Nakagoshi, Maki Wada, Mayu Uka, Noriaki Akagi, Toshiharu Mitsuhashi, Yusuke Matsui, Takao Hiraki

    Acta medica Okayama   78 ( 2 )   135 - 142   2024.4

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    This study aimed to evaluate the potential reduction in contrast medium utilization using photon-counting detector computed tomography (PCD-CT). One PCD-CT scan (CT1) and three conventional (non-PCD-CT) CT scans (CT2-CT4) were performed using a multi-energy CT phantom that contained eight rods with different iodine concentrations (0.2, 0.5, 1, 2, 5, 10, 15, and 20 mg/ml). The CT values of the seven groups (CT1 for 40, 50, 60, and 70 keV; and CT2-4) were measured. Noise and contrast-to-noise ratio (CNR) were assessed for the eight rods at various iodine concentrations. CT2 and CT1 (40 keV) respectively required 20 mg/ml and 5 mg/ml of iodine, indicating that a comparable contrast effect could be obtained with approximately one-fourth of the contrast medium amount. The standard deviation values increased at lower energy levels irrespective of the iodine concentration. The CNR exhibited a decreasing trend with lower iodine concentrations, while it remained relatively stable across all iodine levels (40-70 keV). This study demonstrated that virtual monochromatic 40 keV images offer a similar contrast effect with a reduced contrast medium amount when compared to conventional CT systems at 120 kV.

    DOI： 10.18926/AMO/66916

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  • Midline invasion predicts poor prognosis in diffuse hemispheric glioma, H3 G34-mutant: an individual participant data review. Reviewed International journal

    Yasuhito Kegoya, Yoshihiro Otani, Yohei Inoue, Ryo Mizuta, Fumiyo Higaki, Kana Washio, Shinichiro Koizumi, Kazuhiko Kurozumi, Joji Ishida, Kentaro Fujii, Norio Yamamoto, Yoshihiro Tanaka, Isao Date

    Journal of neuro-oncology   167 ( 1 )   201 - 210   2024.3

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    INTRODUCTION: Diffuse hemispheric glioma, H3 G34-mutant (DHGs), is a newly categorized tumor in pediatric-type diffuse high-grade gliomas, World Health Organization grade 4, with a poor prognosis. Although prognostic factors associated with genetic abnormalities have been reported, few reports have examined the clinical presentation of DHGs, especially from the viewpoint of imaging findings. In this study, we investigated the relationship between clinical factors, including imaging findings, and prognosis in patients with DHGs. METHODS: We searched Medline through the PubMed database using two search terms: "G34" and "glioma", between 1 April 2012 and 1 July 2023. We retrieved articles that described imaging findings and overall survival (OS), and added one DHG case from our institution. We defined midline invasion (MI) as invasion to the contralateral cerebrum, brainstem, corpus callosum, thalamus, and basal ganglia on magnetic resonance imaging. The primary outcome was 12-month survival, estimated using Kaplan-Meier curves and logistic regression. RESULTS: A total of 96 patients were included in this study. The median age was 22 years, and the proportion of male patients was 48.4%. Lesions were most frequently located in the frontal lobe (52.6%). MI was positive in 39.6% of all patients. The median OS was 14.4 months. Univariate logistic regression analysis revealed that OS was significantly worse in the MI-positive group compared with the MI-negative group. Multivariate logistic regression analysis revealed that MI was an independent prognostic factor in DHGs. CONCLUSIONS: In this study, MI-positive cases had a worse prognosis compared with MI-negative cases. PREVIOUS PRESENTATIONS: No portion of this study has been presented or published previously.

    DOI： 10.1007/s11060-024-04587-5

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  • A Case of Migration of a Hydrogel Spacer for Radiotherapy into the Pulmonary Artery. Reviewed

    Katsuhide Kojima, Yuka Takahashi, Soichi Sugiyama, Yudai Asano, Nanako Okawa, Satoko Makimoto, Fumiyo Higaki, Toshihiro Iguchi, Takao Hiraki

    Acta medica Okayama   77 ( 6 )   647 - 650   2023.12

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    A 67-year-old man was referred to our hospital for the diagnosis and treatment of prostate cancer. Multidisciplinary discussion led to intensity-modulated radiotherapy preceded by hormone therapy. Before radiotherapy, a biodegradable hydrogel spacer (HS) was placed between the prostate and rectum to reduce radiation injury risk. Three weeks postplacement, pelvic magnetic resonance imaging revealed HS migration into the pelvic vein. Subsequent whole-body contrast-enhanced computed tomography (CECT) revealed HS migration into the pulmonary artery. The patient showed no symptoms or clinical signs. Radiotherapy was completed uneventfully. Complete absorption of the migrated HS was confirmed using CECT images 5 months postplacement.

    DOI： 10.18926/AMO/66157

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  • Evaluation of the ear ossicles with photon-counting detector CT. Reviewed

    Yuka Takahashi, Fumiyo Higaki, Akiko Sugaya, Yudai Asano, Katsuhide Kojima, Yusuke Morimitsu, Noriaki Akagi, Toshihide Itoh, Yusuke Matsui, Takao Hiraki

    Japanese journal of radiology   2023.8

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Recently, computed tomography with photon-counting detector (PCD-CT) has been developed to enable high-resolution imaging at a lower radiation dose. PCD-CT employs a photon-counting detector that can measure the number of incident X-ray photons and their energy. The newly released PCD-CT (NAEOTOM Alpha, Siemens Healthineers, Forchheim, Germany) has been in clinical use at our institution since December 2022. The PCD-CT offers several advantages over current state-of-the-art energy-integrating detector CT (EID-CT). The PCD-CT does not require septa to create a detector channel, while EID-CT does. Therefore, downsizing the anode to achieve higher resolution does not affect the dose efficiency of the PCD-CT. CT is an indispensable modality for evaluating ear ossicles. The ear ossicles and joints are clearly depicted by PCD-CT. In particular, the anterior and posterior legs of the stapes, which are sometimes unclear on conventional CT scans, can be clearly visualized. We present cases of congenital anomalies of the ossicular chain, ossicular chain dislocation, tympanosclerosis, and cholesteatoma in which PCD-CT was useful. This short article reports the usefulness of PCD-CT in the 3D visualization of the ear ossicles.

    DOI： 10.1007/s11604-023-01485-0

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  • 【腹部の最新画像情報2023】びまん性に著明な卵殻状石灰化が認められた食道平滑筋腫の1例 Reviewed

    岡部 将仁, 浅野 雄大, 児島 克英, 槇本 怜子, 檜垣 文代, 田中 健大, 平木 隆夫

    臨床放射線   68 ( 5 )   461 - 468   2023.5

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    Language：Japanese   Publisher：金原出版(株)  

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  • A Rare Case of Idiopathic Spinal Cord Herniation Treated by DuraGen® Collagen Matrix Graft. Reviewed

    Maho Kamamura, Fumiyo Higaki, Susumu Sasada, Toshi Matsushita, Takao Yasuhara, Isao Date, Takao Hiraki

    Acta medica Okayama   76 ( 6 )   731 - 736   2022.12

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    We report a rare case of idiopathic spinal cord herniation (ISCH) with a history of cerebrospinal fluid (CSF) leakage. ISCH is a protrusion of the spinal cord through a dural defect. Thin constructive interference in steady-state (CISS) images clearly demonstrated the herniated cord in the present case. The myelopathy worsened and the patient underwent surgery for reduction of herniated spinal cord; the dural defect was filled by placing collagen matrix graft (DuraGen®) between the inner and outer dural layers. The patient's symptoms have improved without relapse for 8 months since surgery. This method may be a good surgical option for cases of spinal cord herniation.

    DOI： 10.18926/AMO/64124

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  • 18F-FDG-PET/CTで集積の乏しい低異型度子宮内膜間質肉腫の1例 Reviewed

    丸山 拓夢, 蟹江 悠一郎, 丸川 洋平, 檜垣 文代, 児島 克英, 柳井 広之, 依田 尚之, 平木 隆夫

    臨床放射線   67 ( 8 )   887 - 891   2022.8

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  • MRI multiparametric scoring system for pial blood supply of intracranial meningiomas. Reviewed International journal

    Fumiyo Higaki, Satoshi Inoue, Wakako Oda, Eiji Matsusue, Takao Hiraki

    Acta radiologica open   11 ( 4 )   20584601221091208 - 20584601221091208   2022.4

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    Background: Meningiomas are occasionally fed by pial blood supply (PBS). It is postulated that peritumoral flow void (PTFV), peritumoral brain edema (PTBE), and absence of an arachnoid plane (AP) are useful parameters for evaluating PBS. Purpose: To determine whether conventional magnetic resonance imaging (MRI) using a multiparametric scoring system (MSS) is a useful way to predict PBS. Material and Methods: Forty-six patients were included and divided: PBS and non-PBS groups. Differences between the groups in six parameters of MR imaging were analyzed: tumor size, tumor location, PTBE grade, AP grade, PTFV, and MIB1 labeling index (MIB1-LI) grade. Cutoff values were determined using receiver operating characteristic (ROC) curve analysis for the differentiation of both groups based on statistically significant parameters. All cases were scored as 1 (PBS) or 0 (non-PBS) for each parameter according to set thresholds. Individual scores were totaled for each case, yielding a combined score for each case to obtain a cutoff value using ROC curve analysis for the MSS. Results: Peritumoral brain edema grade, AP grade, PTFV, and MIB-LI grade were statistically associated with PBS. Receiver operating characteristic curve analyses showed that PTBE grade 3 or 4, AP grade 3 or 4, and PTFV positivity had the highest accuracy of 69%, 64%, and 68%, respectively. Regarding the MSS, a cutoff value of 2 had the highest accuracy of 71%; PBS diagnosis was indicated by at least two of the three parameters, namely, PTBE grade, AP grade, and PTFV. Conclusion: The MSS is a useful way to predict PBS in intracranial meningiomas on MRI.

    DOI： 10.1177/20584601221091208

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  • Association between Histological Types and Enhancement of Dynamic CT for Primary Lung Cancer. Reviewed

    Shogo Fukuma, Takayoshi Shinya, Junichi Soh, Ryuichiro Fukuhara, Nanako Ogawa, Fumiyo Higaki, Takehiro Tanaka, Eiki Ichihara, Takao Hiraki, Shinichi Toyooka, Susumu Kanazawa

    Acta medica Okayama   74 ( 2 )   129 - 135   2020.4

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    The aim of this study was to explore enhancement patterns of different types of primary lung cancers on 2-phase dynamic computed tomography (CT). This study included 217 primary lung cancer patients (141 adenocarcinomas [ADs], 48 squamous cell carcinomas [SCCs], 20 small cell lung carcinomas [SCLCs], and 8 others) who were examined using a 2-phase dynamic scan. Regions of interest were identified and mean enhancement values were calculated. After excluding the 20 SCLCs because these lesions had different clinical stages from the other cancer types, the mean attenuation values and subtractions between phases were compared between types of non-small cell lung carcinomas (NSCLCs) using the Kruskal-Wallis test. Late phase attenuation and attenuation of the late minus unenhanced phase (LMU) of SCCs were significantly higher than those of ADs (p<0.05). To differentiate SCC and AD in the late phase, a threshold of 80.21 Hounsfield units (HU) gave 52.9% accuracy. In LMU, a threshold of 52.16 HU gave 59.3% accuracy. Dynamic lung CT has the potential to aid in differentiating among NSCLC types.

    DOI： 10.18926/AMO/58271

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  • Neuromelanin magnetic resonance imaging of nigral volume loss in patients with Parkinson's disease. International journal

    Kenichi Kashihara, Takayoshi Shinya, Fumiyo Higaki

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia   18 ( 8 )   1093 - 6   2011.8

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    Parkinson's disease (PD) is characterized by progressive degeneration of melanin-containing neurons in the substantia nigra pars compacta (SNc). Pathological change has not been detected by neuroimaging techniques in patients with PD in vivo. We examined 80 patients with PD to determine whether degeneration of the SNc is detectable in vivo by MRI. The age-matched controls consisted of 54 patients who had suffered mild acute ischemic stroke. Axial T1-weighted MRI were obtained with a 3-Tesla MRI scanner. The border of the neuromelanin-sensitive region in the SNc was traced manually on these images, and the volume of this area was calculated. The mean volumes for the left and right SNc were significantly reduced in patients with PD compared to the controls. Volume loss became marked in parallel with disease severity and duration. Neuromelanin MRI may be considered as a biomarker of nigral degeneration in patients with PD.

    DOI： 10.1016/j.jocn.2010.08.043

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  • 胃悪性リンパ腫の組織別のFDG-PET/CTの集積 MALTリンパ腫の集積とH.pyloriの関連性について Reviewed

    奥村 能啓, 岡田 裕之, 佐藤 修平, 新家 崇義, 檜垣 文代, アラファト・アルキン, 原田 聡介, 吉尾 浩太郎, 多田 明博, 平木 隆夫, 加地 充昌, 金澤 右

    臨床放射線   56 ( 2 )   205 - 212   2011.2

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  • Reduction of neuromelanin-positive nigral volume in patients with MSA, PSP and CBD. Reviewed

    Kenichi Kashihara, Takayoshi Shinya, Fumiyo Higaki

    Internal medicine (Tokyo, Japan)   50 ( 16 )   1683 - 7   2011

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    OBJECTIVE: Diseases presenting extrapyramidal symptoms are accompanied by nigral cell loss. In the previous study, we demonstrated the reduction of the neuromelanin-positive volume of substantia nigra (SN) pars compacta (SNc) in patients with Parkinson's disease (PD) using 3-Tesla MRI. In the present study we investigated the neuromelanin-positive SNc volume in patients with the other parkinsonian disorders including multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) and compared the results with those with PD, spinocerebellar ataxia (SCA) and controls. PATIENTS AND METHODS: Axial T1-weighted (T1W) images were obtained with a 3-Tesla MRI scanner. The border of the neuromelanin-positive region of the SNc was traced manually on these images with a pentablet pointing device and the SNc volume was calculated. The SNc volumes of 28 patients with MSA, 11 patients with PSP and 10 patients with CBD were compared with those of 80 patients with PD, 9 patients with SCA and 54 patients who had suffered mild acute ischemic stroke as controls. The mean volumes for the left and right SN were used for statistical analyses. RESULTS: The volumes of the neuromelanin-positive SNc region in patients with MSA, PSP and CBD, but not SCA were reduced to the same extent as PD patients compared with controls. CONCLUSION: Reduced volume of the neuromelanin-positive SNc region of patients with MSA, PSP and CBD was detected by neuromelanin MR imaging. Volumetric evaluation of neuromelanin MR imaging may provide a biomarker of nigral degeneration in patients with MSA, PSP and CBD as in patients with PD.

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  • 認知症における胃瘻の問題

    横田 修, 檜垣 文代, 大石 正博, 寺田 整司, 藤沢 嘉勝, 佐々木 健

    Dementia Japan   24 ( 1 )   65 - 66   2010.3

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  • 診断・治療症例 悪性リンパ腫 治療法:CHOP療法 Reviewed

    檜垣 文代, 新家 崇義, 加地 充昌

    PET Journal   ( 7 )   43 - 43   2009.9

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    Language：Japanese   Publisher：先端医療技術研究所  

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  • Preliminary retrospective investigation of FDG-PET/CT timing in follow-up of ablated lung tumor. Reviewed

    Fumiyo Higaki, Yoshihiro Okumura, Shuhei Sato, Takao Hiraki, Hideo Gobara, Hidefumi Mimura, Shiro Akaki, Toshihide Tsuda, Susumu Kanazawa

    Annals of nuclear medicine   22 ( 3 )   157 - 63   2008.4

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    OBJECTIVE: The aim of this study was to clarify the most appropriate follow-up initiation time point for positron emission tomography (PET)/computed tomography (CT) following radio frequency ablation (RFA) of lung tumors, and the cutoff values of maximum standard uptake value (SUV(max)) to evaluate local tumor progression. METHODS: We enrolled 15 patients (8 men, median age 62 years) with 60 tumors, who were treated with RFA of lung tumors and underwent fluorodeoxyglucose (FDG)-PET/CT following RFA. Local tumor progression was assessed by periodic chest CT images prior to and following intravenous administration of a contrast medium. The SUV(max) of three periods, namely, 0-3 months, 3-6 months, and 6-9 months after RFA, was evaluated. The appropriate time point for follow-up initiation and the cutoff value of SUV(max) were determined using receiver-operating characteristic (ROC) analysis. RESULTS: The median follow-up period was 357 days. Of 60 tumors, 10 showed local progression. The area under the ROC curve (Az) for the 6-9 months (P = 0.044) was the largest and almost equal to that of the 3-6 months (P = 0.024). Az for the 0-3 months was the smallest and statistically insignificant (P = 0.705). The cutoff value of 1.5 of SUV(max) at 3-9 months after RFA showed 77.8% sensitivity and 85.7-90.5% specificity. CONCLUSIONS: The appropriate follow-up initiation time point is at least 3 months following RFA. Thus, SUV(max) is a useful and reliable predictive indicator.

    DOI： 10.1007/s12149-007-0113-0

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  • Factors predictive of survival after percutaneous endoscopic gastrostomy in the elderly: is dementia really a risk factor? Reviewed International journal

    Fumiyo Higaki, Osamu Yokota, Masahiro Ohishi

    The American journal of gastroenterology   103 ( 4 )   1011 - 6   2008.4

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    OBJECTIVES: Outcomes, especially survival, after percutaneous endoscopic gastrostomy (PEG) in patients with dementia remain unclear. The aims of this study were to assess the impact of dementia on survival after PEG and to explore the risk factors in elderly patients. METHODS: A total of 311 consecutive Japanese patients who underwent PEG were enrolled in this retrospective cohort study. Dementia was defined according to the standard criteria. After the clinical characteristics of patients with and without dementia were compared, the Kaplan-Meier method and Cox proportional-hazards regression analysis were applied to analyze survival rates. RESULTS: Survival was not significantly different between the two groups. The 12-month survival rate of patients with dementia (N = 143) was 51%, and that of patients without dementia (N = 168) was 49%. More than 20% of patients with dementia lived more than 3 yr after PEG. The predictors of poor survival after PEG were previous subtotal gastrectomy (odds ratio [OR] 2.619, 95% confidence interval [CI] 1.367-5.019), serum albumin <2.8 g/dL (OR 2.081, 95% CI 1.490-2.905), age >80 yr (OR 1.721, 95% CI 1.234-2.399), chronic heart failure (OR 1.541, 95% CI 1.096-2.168), and male gender (OR 1.407, 95% CI 1.037-1.909). CONCLUSIONS: In our series, there was no evidence to support a poorer prognosis after PEG in elderly people with dementia compared with the cognitively preserved elderly. However, if patients are male or of advanced age, have a low serum albumin, chronic heart failure, or subtotal gastrectomy, physicians should inform families that a poor prognosis is expected before performing PEG.

    DOI： 10.1111/j.1572-0241.2007.01719.x

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  • Old-fashioned but modern tube cervical esophagostomy. Reviewed International journal

    Fumiyo Higaki, Masahiro Oishi, Takaya Higaki, Yuu Hayata

    American journal of surgery   192 ( 3 )   385 - 7   2006.9

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Nasogastric tubes (NGT) are used widely for feeding and decompressions of stomach, but they are associated with several complications and discomfort. When prolonged use of NGT is required, percutaneous endoscopic gastrostomy (PEG) should be considered. However, PEG is not feasible for patients with previous gastrectomy. We have performed tube cervical esophagostomy (TCE) for such difficult cases of PEG. METHODS: The current study focused on 7 patients requiring TCE for feeding or decompression from 2004 to 2005 at Tottori Municipal Hospital in Japan. RESULTS: The procedure is relatively simply to perform under local anesthesia and significant complications were not experienced. CONCLUSIONS: Feeding or decompressive TCE is useful alternative procedure in patients where PEG is not feasible or unacceptable.

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Presentations

  • MRIを用いた髄膜腫におけるpial blood supply予測の検討

    日本医学放射線学会総会  2022.4 

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Awards

  • Certificate of Merit award

    2023.12   Radiological Society of North America   Evaluation of Head and Spinal CT Angiography with Photon-counting Detector CT: How Close to the Angiographic and Operative Findings

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Research Projects

  • 定量イメージング技術による単純CTにおける腹部臓器腫瘍の新規診断戦略の開発

    2025.06 - 2026.03

    生口俊浩, 淺原 孝, 檜垣文代, 林 裕晃

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  • 定量画像を用いたフォトンカウンティングCTによる超低線量肺癌検診法の確立

    公益財団法人岡山県健康づくり財団 令和7年度「がんに関する研究助成金」 

    生口俊浩 淺原 孝 檜垣文代 林裕晃

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Class subject in charge

  • General Radiology （2024academic year） special  - その他