研究者詳細 - 坂倉　彰

論文 - 坂倉　彰

分割表示 105 件中 61 - 80 件目／全件表示 >>

Convergent total syntheses of fluvibactin and vibriobactin using molybdenum(VI) oxide-catalyzed dehydrative cyclization as a key step 査読

Akira Sakakura, Shuhei Umemura, Kazuaki Ishihara

CHEMICAL COMMUNICATIONS ( 30 ) 3561 - 3563 2008年

Widely useful DMAP-catalyzed esterification under auxiliary base- and solvent-free conditions 査読

Akira Sakakura, Kirnio Kawajiri, Takuro Ohkubo, Yuji Kosugi, Kazuaki Ishihara

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 129 ( 47 ) 14775 - 14779 2007年11月

Enantioselective biomimetic polyene cyclization of polyprenoids - Long-sought enantioselective reaction induced by a "chiral halonium ion" 査読

Akira Sakakura, Kazuaki Ishihara

CHIMICA OGGI-CHEMISTRY TODAY 25 ( 5 ) 9 - 12 2007年9月

Catalytic synthesis of peptide-derived thiazolines and oxazolines using Bis(quinolinolato)dioxomolybdenum(VI) complexes 査読

Akira Sakakura, Rei Kondo, Shuhei Umemura, Kazuaki Ishihara

ADVANCED SYNTHESIS & CATALYSIS 349 ( 10 ) 1641 - 1646 2007年7月

Dehydrative cyclization catalyzed by the combination of molybdenum(VI) oxides and benzoic acids: First synthesis of the antitumour substance BE-70016 査読

Akira Sakakura, Shuhei Umemura, Rei Kondo, Kazuaki Ishihara

ADVANCED SYNTHESIS & CATALYSIS 349 ( 4-5 ) 551 - 555 2007年3月

Design of highly functional small-molecule catalysts and related reactions based on acid-base combination chemistry 査読

Kazuaki Ishihara, Akira Sakakura, Manabu Hatano

SYNLETT ( 5 ) 686 - 703 2007年3月

Enantioselective halocyclization of polyprenoids induced by nucleophilic phosphoramidites 査読

Akira Sakakura, Atsushi Ukai, Kazuaki Ishihara

NATURE 445 ( 7130 ) 900 - 903 2007年2月

Unusual rate acceleration in bronsted acid catalyzed dehydration reactions: Local hydrophobic environment in aggregated N-(2,6-diphenylphenyl)-N-mesitylammonium pentafluorobenzenesulfonates 査読

Akira Sakakura, Hitoshi Watanabe, Shoko Nakagawa, Kazuaki Ishihara

CHEMISTRY-AN ASIAN JOURNAL 2 ( 4 ) 477 - 483 2007年

Direct ester condensation catalyzed by bulky diarylammonium pentafluorobenzenesulfonates 査読

Akira Sakakura, Shoko Nakagawa, Kazuaki Ishihara

NATURE PROTOCOLS 2 ( 7 ) 1746 - 1751 2007年

Bulky phosphazenium cation catalysis for dehydrative condensation of phosphoric acid with alcohols 査読

Akira Sakakura, Mikimoto Katsukawa, Takaomi Hayashi, Kazuaki Ishihara

GREEN CHEMISTRY 9 ( 11 ) 1166 - 1169 2007年

The oxorhenium(VII)-catalyzed direct condensation of phosphoric acid with an alcohol 査読

Akira Sakakura, Mikimoto Katsukawa, Kazuaki Ishihara

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 46 ( 9 ) 1423 - 1426 2007年

Enantioselective Diels-Alder reaction of alpha-acyloxyacroleins catalyzed by chiral 1,1 '-binaphthyl-2,2 '-diammonium salts 査読

Akira Sakakura, Kenji Suzuki, Kazuaki Ishihara

ADVANCED SYNTHESIS & CATALYSIS 348 ( 16-17 ) 2457 - 2465 2006年11月

35 細胞毒性マクロリド配糖体、オーリサイド類の合成(口頭発表の部)

末永聖武, 星野紘史, 好井孝典, 森和規, 曽根大紀, 別所祐紀, 坂倉彰, 早川一郎, 山田靜之, 木越英夫

天然有機化合物討論会講演要旨集 ( 48 ) 205 - 210 2006年9月

記述言語：日本語出版者・発行元：天然有機化合物討論会

Aurisides A (1) and B (2) are macrolide glycosides isolated from Japanese sea hare Dolabella auricuralia, which exhibit cytotoxicity against HeLa S_3 cells with IC_<50> values of 0.17 and 1.2μg/mL, respectively. The main structural features of aurisides are a bromine-substituted conjugated diene, a 14-membered lactone, and a cyclic hemiacetal. We achieved the enantioselective synthesis of aurisides A and B by a convergent approach. The C1-C9 segment 4 was prepared from (R)-pantolactone using a reaction of dithiane carbanion with epoxide, stereoselective reduction of β-hydroxyketone with Me_4NBHOAc, and rhodium-catalyzed Reformatsky-type reaction as key steps. The C10-C17 segment 12 was synthesized from (R)-glycidyl trityl ether. The Nozaki-Hiyama-Kishi reaction between 4 and 12 and subsequent reactions including construction of bromine-substituted conjugated diene gave seco acid 10, which was converted into the aglycon (3) of aurisides by construction of the 14-membered lactone. The Mukaiyama glycosylation reaction of the aglycon 3 provided aurisides A (1) and B (2).

DOI： 10.24496/tennenyuki.48.0_205

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8 海洋産抗腫瘍性化合物アプリロニンAの抗腫瘍機序(口頭発表の部)

黒田武史, 末永聖武, 半田知久, 宮沙織, 岡本和人, 兼松憲吾, 坂倉彰, 山田靜之, 平田邦生, 高田昌樹, 加藤健一, 村岡真, 山本雅貴, 田中宏志, 木越英夫

天然有機化合物討論会講演要旨集 ( 48 ) 43 - 48 2006年9月

記述言語：日本語出版者・発行元：天然有機化合物討論会

The interaction between actin and aplyronine A, a potent antitumor and actin-depolymerizing substance of marine origin, was investigated by photoaffinity labeling experiments and X-ray structure analysis of actin complex with aplyronine A. Photoaffinity probes consisting of a side-chain portion of aplyronine A as a ligand, a diazirine moiety as a photoaffinity group, and a fluorophor as a detecting group were synthesized. Photolabeling experiments between actin and the probe were carried out. Actin was successfully photolabeled by the fluorescent probe and visualized clearly. The present results provide the first chemical evidence for the direct interaction between actin and the side-chain portion of aplyronine A. X-ray structure analysis of actin-aplyronine A complex was carried out. The analysis showed that Aplyronine A bound to a hydrophobic cleft between subdomains 1 and 3 of actin. The structural feature is that the trimethylserine moiety protrudes toward the bulk solvent region.

DOI： 10.24496/tennenyuki.48.0_43

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Enantioselective synthesis of aurisides A and B, cytotoxic macrolide glycosides of marine origin 査読

Kiyotake Suenaga, Hiroshi Hoshino, Takanori Yoshii, Kazunori Mori, Hiroki Sone, Yuhki Bessho, Akira Sakakura, Ichiro Hayakawa, Kiyoyuki Yamada, Hideo Kigoshi

TETRAHEDRON 62 ( 33 ) 7687 - 7698 2006年8月

Synthesis and biological activity of mycalolide analogs 査読

Kiyotake Suenaga, Tomoyuki Kimura, Takeshi Kuroda, Keita Matsui, Saori Miya, Satomi Kuribayashi, Akira Sakakura, Hideo Kigoshi

TETRAHEDRON 62 ( 35 ) 8278 - 8290 2006年8月

P-81 ENANTIOSELECTIVE POLYENE HALOCYCLIZATION INDUCED BY NUCLEOPHILIC CHIRAL PHOSPHINES

Sakakura Akira, Ukai Atsushi, Ishihara Kazuaki

International Symposium on the Chemistry of Natural Products 2006 "P - 81" 2006年7月

Development of environmentally benign catalytic dehydration process 査読

Akira Sakakura, Kazuaki Ishihara

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN 64 ( 6 ) 651 - 663 2006年6月

Chiral 1,1 '-binaphthyl-2,2 '-diammonium salt catalysts for the enantioselective Diels-Alder reaction with alpha-acyloxyacroleins 査読

Akira Sakakura, Kenji Suzuki, Kazuhiko Nakano, Kazuaki Ishihara

ORGANIC LETTERS 8 ( 11 ) 2229 - 2232 2006年5月

Study of the interaction between actin and antitumor substance aplyronine A with a novel fluorescent photoaffinity probe 査読

Takeshi Kuroda, Kiyotake Suenaga, Akira Sakakura, Tomohisa Handa, Kazuhito Okamoto, Hideo Kigoshi

Bioconjugate Chemistry 17 ( 2 ) 524 - 529 2006年3月

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