Faculty Profiles - YOSHIOKA Norie

Papers - YOSHIOKA Norie

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Familial adenoid cystic carcinoma of sublingual salivary glands Reviewed

Norie Yoshioka, Hiroshi Mese, Tatsuo Okui, Soichiro Ibaragi, Akira Sasaki

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY 27 ( 3 ) 353 - 356 2015.5

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE INC

Tumors of the sublingual salivary gland are extremely rare. Most of the sublingual tumors are malignant, adenoid cystic carcinoma (ACC) and mucoepidermoid carcinoma being the most common histological types. Here we report the first case of a familial occurrence of ACC in a family in which the father and daughter were treated for ACC of the sublingual salivary gland. A 75-year-old man was referred with a swelling of the floor of the mouth on his right side and diagnosed as ACC of sublingual salivary gland synchronous with adenocarcinoma of the lung. One year later, his daughter presented, at the age of 46 years, with a swelling of the floor of the mouth on her right side, which was also diagnosed as ACC. This is the first case of familial recurring ACC of sublingual salivary gland worldwide. (C) 2014 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI. Published by Elsevier Ltd. All rights reserved.(star)

DOI： 10.1016/j.ajoms.2014.03.008

Expression pattern of sonic hedgehog signaling and calcitonin gene related peptide in the socket healing process after tooth extraction Reviewed

Pang P, Shimo T, Takada H, Matsumoto K, Yoshioka N, Ibaragi S, Sasaki A

BBRC 467 21 - 26 2015

Expression and roles of CCN2 in dental epithelial cells Reviewed

Shimo T, Koyama E, Kurio N, Matsumoto K, Okui T, Ibaragi S, Yoshioka N, Sasaki A

In vivo 9 189 - 195 2015

Installing an original sleeve for rod unaccessible pain from a distraction device in a hemifacial microsomia patient

Tsuyoshi Shimo, Akiyoshi Nishiyama, Norie Yoshioka, Akira Sasaki

INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS 12 137 - 139 2015

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCI LTD

INTRODUCTION: Lengthening of the mandible by distraction osteogenesis using an internal device is the preferred method for the treatment of hemifacial microsomia. Despite its advantages, this technique can lead to various complications after the surgery.PRESENTATION OF CASE: We report the case of an 8-yr-old Japanese girl whose case presented practical difficulties in device activation because of rod unaccessible pain after the initial mandibular distraction with an internal device, and this complication was addressed with the installation of an original sleeve.DISCUSSION: In the present patient, the region of the bend rod was located at the inferior border of the right mandible, causing rod unaccessible pain by contacting the surrounding tissue including a sensory nerve. Careful vertical ramus distractor position planning and tools to resolve complications are the key factors for accomplishing the scheduled elongation.CONCLUSION: Alternative techniques using a sleeve for safer and gentle distraction for rod unaccessible pain on activation should be considered. (C) 2015 The Authors. Published by Elsevier Ltd. on behalf of Surgical Associates Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

DOI： 10.1016/j.ijscr.2015.05.037

岡山大学病院口腔がん専門外来と岡山市歯科医師会の連携による口腔がん検診研修会の概要とアンケート結果について

岸本晃治, 岡崎景, 西山明慶, 居樹秀明, 松村達志, 伊原木聰一郎, 銅前昇平, 吉岡徳枝, 栗尾奈愛, 矢尾真弓, 小畑協一, 尾野裕子, 志茂剛, 壺内智郎, 飯田征二, 佐々木朗

岡山歯学会雑誌 33 ( 2 ) 23 - 28 2014.12

Language：Japanese Publisher：岡山歯学会

口腔癌検診研修会基礎コースを修了した歯科医師を対象に、研修会終了後にアンケート調査を行った。2013年に行われた3回の研修会の研修者の合計は46人(3人が2回研修)であった。臨床経験年数は10〜42年(平均23.6年、中央値25年)に比較的長い研修者が多かった。口腔癌症例経験ありは70%に認められ、経験症例数は1〜3例が多かった。口腔癌症例経験者の中で癌の疑いがあると診断して専門機関に紹介した症例が93%と大部分を占めた。しかし、その中で早期癌を診断できた症例は45%に過ぎず、初診時に進行していた症例も46例に認められた。また、紹介が少し遅くなった症例が9%認められたが患者が専門機関をなかなか受診してくれなかった例も1例あった。癌の部位は舌が最も多く41%認められ、下顎歯肉32%、口底13%と続いた。研修会の時間・レベルは概ね適切で、講義・実習・テキストもためになり、今後の臨床に役立つとの回答が得られた。再研修の必要性は91%と多かったが、アドバンスコースの希望者は69%に留まり、ベーシックコースの希望者も22%認められた。また、再研修までの期間は1年の35%を前後にばらつきが認められた。研修者はより実践的に役立つ研修内容を希望していた。

骨髄移植後の慢性GVHD患者に発生した多発性口腔扁平上皮癌の1例

奥井達雄, 目瀬浩, 伊原木聰一郎, 吉岡徳枝, 志茂剛, 佐々木朗

日本口腔外科学会雑誌 60 ( 3 ) 151 - 155 2014.3

Language：Japanese Publisher：(公社)日本口腔外科学会

症例は42歳男性で、全身倦怠感を主訴に受診し、慢性骨髄性白血病と診断された。HLAが一致する弟をドナーとした骨髄移植を受け、移植直後に移植片対宿主病(GVHD)を発症し、慢性GVHDによる肝機能低下、GVHDに対するプレドニゾロン長期投与による軽度の腎機能低下を認めた。骨髄移植直後より口内炎を自覚していたが、右側頬粘膜に腫瘤を自覚するようになり、血液腫瘍内科より紹介受診した。体格中等度、栄養状態良好で、顔面、四肢皮膚に慢性GVHDによる色素逸脱を認めた。右側頬粘膜に22×16mmの弾性軟、周囲に硬結を触知する腫瘤を認めた。MR画像で右側頬粘膜に前後径20mm、厚み4mmの境界明瞭なSTIR高信号域を認め、左側下顎小臼歯部舌側歯肉に前後径10mmの境界明瞭なSTIR高信号域を認めた。骨髄移植によるGVHDを伴った二次性多発性口腔癌、白板症の疑いと臨床診断し、全身麻酔下に腫瘍切除術を施行した。左側下顎生検を行い、舌背中央部は軽度上皮異形成、左側下顎大臼歯歯肉頬移行部は高分化扁平上皮癌と病理組織学的に診断され、左側下顎歯肉癌に対し腫瘍切除術を施行した。術後12ヵ月再発を認めず、厳重な経過観察を行っている。

DOI： 10.5794/jjoms.60.151

Expression and roles of CCN2 in dental mesenchymal cells in primary culture-With findings in a case of odontogenic myxofibroma

Tsuyoshi Shimo, Eiki Koyama, Yuu Horikiri, Tatsuo Okui, Naito Kurio, Naoki Katase, Shoko Yoshida, Yuichiro Takebe, Koji Kishimoto, Norie Yoshioka, Hitoshi Nagatsuka, Akira Sasaki

Oral Science International 11 ( 1 ) 8 - 14 2014.1

Language：English Publishing type：Research paper (scientific journal)

Purpose of the research: Tooth germ development involves multiple events, including cell proliferation and cell differentiation. Connective tissue growth factor (CTGF/CCN2) is a signaling protein involved in tooth germ development, and we investigated how it is expressed and what roles it may have in primary cultures of mesenchymal cells derived from the developing tooth germ. We also examined the expression of CCN2 in a human odontogenic myxofibroma, a benign tumor of odontogenic mesenchymal origin, and considered the possible roles of CCN2 in the development of myxofibromas. Materials and methods: Mesenchymal cells of early bell-stage tooth germs were isolated from Day-90 bovine embryos and placed in primary culture. A resected specimen from a patient with odontogenic myxofibroma was prepared for immunohistochemical studies. Principal results: The CCN2 expression level in proliferating odontogenic mesenchymal cells freshly isolated from the early bell stage of developing bovine tooth germs and placed in primary culture was 3 times higher than that in the confluent non-proliferating cells. Recombinant CCN2 significantly increased the proliferation and type I collagen expression in odontogenic mesenchymal cells in primary culture. Immunohistochemical analysis on myxofibroma case revealed that CCN2 was detectable in MIB-1, a cellular marker of proliferation-positive odontogenic mesenchymal cells adjacent to capillary blood vessels and in the endothelial cells of the vessels in the tumor. Major conclusion: CCN2 signaling would influence the proliferation of and extracellular matrix production by dental mesenchymal cells. Our results suggest that the same mechanisms of CCN2 action toward dental mesenchymal cells would also be operative in the odontogenic myxofibroma microenvironment. © 2013 Japanese Stomatological Society.

DOI： 10.1016/S1348-8643(13)00008-6

Neamine inhibits oral cancer progression bysuppressing angiogenin-mediated angiogenesis and cancer cell proliferation. Reviewed

Kishimoto K, Yoshida S, Ibaragi S, Yoshioka N, Okui T, Hu GF, Sasaki A

Anticancer Res 34 2113 - 2121 2014

Oral infection control to assist infliximab therapy in a Behçet's disease patient with severe eye inflammation in response to dental treatment: a case report. International journal

Chieko Kudo, Hiroshi Wakabayashi, Masayuki Shimoe, Hiroya Kobayashi, Takashi Ito, Toshinori Ohkawa, Arisa Isoshima-Nakamura, Junji Mineshiba, Norie Yoshioka, Kumiko Nawachi, Hiroshi Maeda, Toshihiko Matsuo, Hirofumi Makino, Shogo Takashiba

Clinical case reports 2 ( 6 ) 274 - 280 2014

エナメル上皮腫摘出後に骨移植と骨延長により骨増量を行ったインプラント治療の1例

伊原木聰一郎, 目瀬浩, 中山周子, 兒玉真一, 奥井達雄, 吉岡徳枝, 岸本晃治, 中妻可奈子, 志茂剛, 佐々木朗

Japanese Journal of Maxillo Facial Implants 12 ( 2 ) 53 - 57 2013.8

Language：Japanese Publisher：(公社)日本顎顔面インプラント学会

59歳女。右側頬部の腫脹を主訴に受診し、パノラマX線写真で右側下顎骨にX線透過像を認めた。CT写真では、腫瘍直下に下顎管が存在していた。局研麻酔下で生検を行い、エナメル上皮腫と診断した。全身麻酔下に腫瘍摘出術および抜歯を施行した。病理組織学的所見からエナメル上皮腫と診断した。腫瘍摘出術後3年3ヵ月後にインプラント治療に先立ち、下歯槽神経血管束移動術と右側下顎枝からの骨移植を行った。4ヵ月の治癒期間の後、骨延長を行った。頬側の骨量が不十分であったため、オトガイ部からの骨移植を再度行い、1年2ヵ月後にインプラント体を埋入した。現在、上部構造装着から4年が経過しているが、腫瘍の再発や、インプラント周囲粘膜組織の炎症徴候もなく、正常な咬合・咀嚼機能が維持されている。さらにパノラマX線写真においてもインプラント周囲の異常な骨吸収はなく、歯槽骨頂の骨レベルは維持され、経過は良好である。

Angiogenin mediates androgen-stimulated prostate cancer growth and enables castration resistance. Reviewed International journal

Li S, Hu MG, Sun Y, Yoshioka N, Ibaragi S, Sheng J, Sun G, Kishimoto K, Hu GF

Mol Cancer Res. 11 ( 10 ) 1203 - 1214 2013

Language：English Publishing type：Research paper (scientific journal)

UNLABELLED: The androgen receptor (AR) is a critical effector of prostate cancer development and progression. Androgen-dependent prostate cancer is reliant on the function of AR for growth and progression. Most castration-resistant prostate cancer (CRPC) remains dependent on AR signaling for survival and growth. Ribosomal RNA (rRNA) is essential for both androgen-dependent and castration-resistant growth of prostate cancer cells. During androgen-dependent growth of prostate cells, androgen-AR signaling leads to the accumulation of rRNA. However, the mechanism by which AR regulates rRNA transcription is unknown. Here, investigation revealed that angiogenin (ANG), a member of the secreted ribonuclease superfamily, is upregulated in prostate cancer and mediates androgen-stimulated rRNA transcription in prostate cancer cells. Upon androgen stimulation, ANG undergoes nuclear translocation in androgen-dependent prostate cancer cells, where it binds to the rDNA promoter and stimulates rRNA transcription. ANG antagonists inhibit androgen-induced rRNA transcription and cell proliferation in androgen-dependent prostate cancer cells. Interestingly, ANG also mediates androgen-independent rRNA transcription through a mechanism that involves its constitutive nuclear translocation in androgen-insensitive prostate cancer cells, resulting in a constant rRNA overproduction and thereby stimulating cell proliferation. Critically, ANG overexpression in androgen-dependent prostate cancer cells enables castration-resistant growth of otherwise androgen-dependent cells. Thus, ANG-stimulated rRNA transcription is not only an essential component for androgen-dependent growth of prostate cancer but also contributes to the transition of prostate cancer from androgen-dependent to castration-resistant growth status. IMPLICATIONS: The ability of angiogenin to regulate rRNA transcription and prostate cancer growth makes it a viable target for therapy.

DOI： 10.1158/1541-7786.MCR-13-0072

Hypoxia-induced up-regulation of angiogenin, besides VEGF, is related to progression of oral cancer Reviewed International journal

Koji Kishimoto, Shoko Yoshida, Soichiro Ibaragi, Norie Yoshioka, Tatsuo Okui, Guo-fu Hu, Akira Sasaki

Oral Oncology 48 ( 11 ) 1120 - 1127 2012.11

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

OBJECTIVES: Angiogenin (ANG) is a prominent angiogenic factor that has been shown to have a dual effect on tumor progression by inducing both angiogenesis and cancer cell proliferation through stimulating ribosomal RNA transcription in both endothelial cells and cancer cells. In the present study, we investigated the expression profiles of ANG and vascular endothelial growth factor (VEGF) in oral cancer and their correlation with hypoxia and evaluated the possible value of ANG as a therapeutic target for oral cancer. MATERIALS AND METHODS: Immunohistochemistry (IHC), ELISA, real-time RT-PCR and Western blotting were used to examine the expression of ANG, VEGF, and hypoxia-inducible factor 1α (HIF-1α) in oral squamous cell carcinoma (OSCC) specimens and human OSCC cell lines. In order to examine the role of ANG, we knocked down ANG expression in HSC-2 cells by means of plasmid-mediated RNA interference. RESULTS: IHC showed that the expression of ANG was significantly correlated with that of HIF-1α in 50 OSCC specimens (P = 0.031). However, no significant correlation between VEGF and HIF-1α expression was found (P = 0.243). Consistently, ANG secretion increased under hypoxia in all of the 10 OSCC cell lines tested; and a significant increase was observed in 6 of them. In contrast, there was no noticeable increase in VEGF secretion under hypoxia in any of these cell lines. In HSC-2 and SAS OSCC cells, the increase in ANG mRNA expression correlated very well with that of HIF-1α protein expression after hypoxia onset. However, no noticeable increase in VEGF mRNA expression was observed even after 12 h of hypoxia. Down-regulation of ANG expression in HSC-2 cells highly expressing and secreting VEGF inhibited ribosome biogenesis, cell proliferation, tumor angiogenesis, and xenograft growth in athymic mice. CONCLUSION: These results suggest that ANG is up-regulated in the hypoxic environment of oral cancers and that its inhibition can have a therapeutic implication.

DOI： 10.1016/j.oraloncology.2012.05.009

幼児の上顎歯肉に発生した巣状口腔粘液症の1例 Reviewed

伊原木聰一郎, 西山明慶, 吉岡徳枝, 片瀬直樹, 長塚仁, 佐々木朗

日本口腔外科学会雑誌 58 ( 9 ) 546 - 549 2012.9

Language：Japanese Publisher：(公社)日本口腔外科学会

1歳7ヵ月女児。左側上顎歯肉の腫瘤を主訴とした。左側上顎歯肉に弾性軟の有茎性腫瘤を認め、腫瘤の先端は分葉状で正常歯肉色であったが、腫瘤基部は血管が豊富で赤色を呈していた。デンタルX線で同部の骨吸収は認めなかった。左側上顎歯肉腫瘍と診断し、腫瘍切除術を行った。腫瘤は有茎性で基部は歯肉と歯槽粘膜の境界部に存在しており、基部から約5mmの安全域を設定し直下の骨膜も切除した。同部の骨面は正常であった。切除部は開放創にして手術を終了した。切除した腫瘍の病理診断は巣状口腔粘液症であった。術後経過は良好で、術後1年の現在、再発は認めていない。

DOI： 10.5794/jjoms.58.546

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2012&ichushi_jid=J01073&link_issn=&doc_id=20121003390008&doc_link_id=10.5794%2Fjjoms.58.546&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.58.546&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Beckwith-Wiedemann症候群による巨舌に起因する著明な開咬に対して顎矯正手術を施行した1例 Reviewed

吉岡徳枝, 西山明慶, 伊原木聰一郎, 奥井達雄, 高橋巧, 佐々木朗

日本顎変形症学会雑誌 22 ( 2 ) 112 - 112 2012.5

A clinical study of patients aged 75 and older with oral squamous cell carcinoma Reviewed

YOSHIDA Shoko, KISHIMOTO Koji, IBARAGI Soichiro, DOMAE Shohei, YOSHIOKA Norie, SHIMO Tsuyoshi, NISHIYAMA Akiyoshi, MESE Hiroshi, SASAKI Akira

Journal of Japanese Society of Oral Oncology 24 ( 3 ) 103 - 111 2012

Language：Japanese Publisher：Japanese Society of Oral Oncology

As the aging society is advancing in our country, it is expected that the opportunity to treat oral cancer in elderly patients is increasing. In this report, 64 patients (23 male and 41 female) aged 75 and older with oral squamous cell carcinoma (OSCC) were clinically evaluated as compared with 60 patients (32 male and 28 female) aged 65-74 years old, and 63 patients (46 male and 17 female) aged 64 and younger with OSCC who were treated at our clinic between 2000 and 2008.<br>The ratio of Performance Status (PS) grade 0·1 patients in the group aged 75 and older was significantly lower than that in the groups aged 65-74 and those aged 64 and younger. The number of patients aged 75 and older are divided into the radical cure treatment group, palliative treatment group and no treatment group, which accounts for 45 (70.3%), 9 (14.1%), and 10 (15.6%) cases, respectively. The ratio of the radical cure treatment patients in the group aged 75 and older was lower than that in the group aged 65-74. The 5-year cause-specific survival rates of radical cure treatment in the groups aged 75 and older, 65-74 and 64 and younger were 81.3%, 88.6% and 80.9%, respectively. The survival rate of the group aged 75 and older was lower than that aged 65-74. We could not follow up with the patients who underwent no treatment. Therefore, it is necessary to consider a solution to this problem in the future.

DOI： 10.5843/jsot.24.103

Other Link： http://search.jamas.or.jp/link/ui/2013021703

口腔癌切除後の創部に対してポリグリコール酸フェルトとフィブリン糊を併用した被覆法の使用経験

伊原木聰一郎, 岸本晃治, 吉岡徳枝, 銅前昇平, 志茂剛, 中妻可奈子, 辻本紗代子, 栗尾奈愛, 兒玉真一, 武部祐一郎, 堀切優, 柴田茜, 西山明慶, 目瀬浩, 佐々木朗

岡山歯学会雑誌 29 ( 2 ) 107 - 112 2010.12

Language：Japanese Publisher：岡山歯学会

口腔癌切除後の創部に対してポリグリコール酸フェルトとフィブリン糊を併用した被覆法を用いて治療を行った4例を経験した。症例1は80歳女で、右側舌癌に対して舌部分切除術を行った。術後21日目においてほぼPGAフェルトは吸収し、舌の瘢痕拘縮は軽度であった。症例2は65歳女で、左側頬粘膜悪性黒色腫に対して頬粘膜腫瘍切除術と上顎骨部分切除術を行った。術後28日目においてPGAフェルトは吸収しており、瘢痕拘縮は軽度で開口障害もなかった。症例3は78歳女で、左側下顎歯肉癌に対して下顎骨辺縁切除術と頸部郭清術を行った。術後31日目において、骨露出は認めず肉芽で覆われている。症例4は88歳女で、左側頬粘膜癌に対して原発巣は密封小線源治療、頸部リンパ節転移は頸部郭清術を行うこととした。術後44日目において肉芽の新生は十分でなく、頬粘膜は陥凹している。

臼後部に発生した嚢胞腺癌の1例 Reviewed

岸本晃治, 吉田祥子, 銅前昇平, 吉岡徳枝, 志茂剛, 佐々木朗

日本口腔外科学会雑誌 56 ( 12 ) 720 - 724 2010.12

Language：Japanese Publisher：(公社)日本口腔外科学会

症例は90歳男性で、右側下顎臼後部歯肉の違和感、義歯による痛みが出現し、近医の義歯調節で痛みは消失したが、同部に腫瘤を指摘され紹介受診した。右側下顎臼後部に弾性硬、表面がカリフラワー状の境界明瞭な18×16mm大の外向性腫瘤を認めた。CTで同部に12×11×14mm大の類円形病巣と骨髄に達する下掘れ状の骨吸収像を認めた。生検で腫瘍細胞の増殖による嚢胞腔形成と乳頭状構造、一部に細胞異型や分裂像を認め、低悪性の嚢胞腺癌を疑って下顎骨辺縁切除術を行った。病理所見では腫瘍は大小の嚢胞腔を形成して外向性に増殖し、一方で下顎骨内に嚢胞腔を形成して下掘れ状の骨吸収像を認めた。腫瘍は嚢胞腔内に乳頭状増殖を示し、間質に線維性結合組織の増生と硝子化を認め、嚢胞を裏層する腫瘍細胞は円形の核と好酸性の細胞質を有する円柱状細胞からなり、一部に異型や分裂像を認めた。病理診断は低悪性嚢胞腺癌であった。術後2年経過で再発や転移は認めていない。

DOI： 10.5794/jjoms.56.720

エナメル上皮腫に対する外科療法の治療成績と再発に関する臨床的検討 Reviewed

吉田祥子, 塚本剛一, 吉岡徳枝, 志茂剛, 岸本晃治, 西山明慶, 大山和彦, 目瀬浩, 長塚仁, 佐々木朗

日本口腔腫瘍学会誌 22 ( 1 ) 37 - 43 2010.3

Language：Japanese Publisher：(一社)日本口腔腫瘍学会

エナメル上皮腫の治療法については論議のあるところである。当科においては、周囲骨の穿孔がないかもしくはわずかであれば、保存的外科療法-骨面削除と凍結療法を併用した摘出術-を基本的に選択している。当論文では、当科開設の1982年から2007年までの25年間に経験したエナメル上皮腫50例、特に再発症例について検討を行った。50例の手術の内訳は、摘出術12例、摘出と骨面削除または骨面削除および凍結療法(摘出+補助療法)が21例、顎骨切除(辺縁切除と区域切除)が17例であった。再発は6例であり(再発率:12%)、摘出術に5例(再発率:42%)、摘出+補助療法に1例(再発率:5%)認めた。顎骨切除術は再発を認めなかった。摘出と顎骨切除との間および、摘出と摘出+補助療法との間に再発率に関し有意差を認めた。以上より、エナメル上皮腫の保存的外科療法において、骨面削除と凍結療法は有用であることが示唆された。(著者抄録)

DOI： 10.5843/jsot.22.37

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2010&ichushi_jid=J02382&link_issn=&doc_id=20100318180005&doc_link_id=%2Fdy8ortum%2F2010%2F002201%2F006%2F0037-0043%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdy8ortum%2F2010%2F002201%2F006%2F0037-0043%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

当科における口腔扁平上皮癌の治療成績(第1報)

岸本晃治, 吉田祥子, 伊原木聰一郎, 銅前昇平, 吉岡徳枝, 志茂剛, 塚本剛一, 西山明慶, 目瀬浩, 松村智弘, 佐々木朗

岡山歯学会雑誌 28 ( 1 ) 43 - 50 2009.6

Language：Japanese Publisher：岡山歯学会

根治的治療を施行した口腔扁平上皮癌一次症267例において、臨床病理学的諸因子ならびに治療法別の治療成績を評価した。Stage分類、T分類、N分類、原発巣分化度、浸潤様式、再発・転移の因子が、有意に生存率に影響を及ぼした。頬粘膜癌が他の癌に比べ有意に予後不良であった。手術群、術前照射群、術前化学療法群、組織内照射群、放射線動注化学療法群、放射線療法群の5年疾患特異的累積生存率は、それぞれ74.1%、77.1%、100%、97.2%、91.7%.100%であった。根治的治療群における5年累積生存率は全症例77.4%、再発・転移群46.7%であった。N分類および分化度が独立した予後規定因子となった。治療後に評価できる因子である再発・転移(あり/なし)の項目を加え、生存率について多変量解析を行い、再発・転移の因子のみが独立した予後規定因子となった。

Neamine Inhibits Prostate Cancer Growth by Suppressing Angiogenin-Mediated rRNA Transcription Reviewed

Soichiro Ibaragi, Norie Yoshioka, Shuping Li, Miaofen G. Hu, Saori Hirukawa, Peter M. Sadow, Guo-fu Hu

CLINICAL CANCER RESEARCH 15 ( 6 ) 1981 - 1988 2009.3

Language：English Publishing type：Research paper (scientific journal) Publisher：AMER ASSOC CANCER RESEARCH

Purpose: Angiogenin (ANG) undergoes nuclear translocation and stimulates rRNA transcription in both prostate cancer cells and endothelial cells. The purpose of this study is to assess the antitumor activity of neamine, a nontoxic degradation product of neomycin that blocks nuclear translocation of ANG.
Experimental Design: The anti-prostate cancer activity of neamine was first evaluated in a xenograft animal model. It was then examined in the murine prostate-restricted AKT transgenic mice that develop prostate intraepithelial neoplasia (PIN) owing to AKT transgene overexpression.
Results: Neamine inhibits xenograft growth of PC-3 human prostate cancer cells in athymic mice. It blocks nuclear translocation of ANG and inhibits rRNA transcription, cell proliferation, and angiogenesis. Neamine also prevents AKT-induced PIN formation as well as reverses fully developed PIN in murine prostate-restricted AKT mice, accompanied by a decrease in rRNA synthesis, cell proliferation, and angiogenesis and an increase in prostate epithelial cell apoptosis.
Conclusion: We confirmed that ANG is a molecular target for cancer drug development and that blocking nuclear translocation of ANG is an effective means to inhibit its activity. Our results also suggested that neamine is a lead compound for further preclinical evaluation.

DOI： 10.1158/1078-0432.CCR-08-2593

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