Faculty Profiles - iwasaki keiichiro

Papers - iwasaki keiichiro

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Anemia in Patients with Severe Aortic Stenosis

Kazuya Nagao, Tomohiko Taniguchi, Takeshi Morimoto, Hiroki Shiomi, Kenji Ando, Norio Kanamori, Koichiro Murata, Takeshi Kitai, Yuichi Kawase, Chisato Izumi, Makoto Miyake, Hirokazu Mitsuoka, Masashi Kato, Yutaka Hirano, Shintaro Matsuda, Tsukasa Inada, Tomoyuki Murakami, Yasuyo Takeuchi, Keiichiro Yamane, Mamoru Toyofuku, Mitsuru Ishii, Eri Minamino-Muta, Takao Kato, Moriaki Inoko, Tomoyuki Ikeda, Akihiro Komasa, Katsuhisa Ishii, Kozo Hotta, Nobuya Higashitani, Yoshihiro Kato, Yasutaka Inuzuka, Chiyo Maeda, Toshikazu Jinnai, Yuko Morikami, Naritatsu Saito, Kenji Minatoya, Takeshi Kimura

Scientific Reports 9 ( 1 ) 2019.12

Experience of the use of octreotide for refractory gastrointestinal bleeding in a patient with Jarvik2000® left ventricular assist device

Seiko Nakajima-Doi, Osamu Seguchi, Yasuhiro Shintani, Tomoyuki Fujita, Satsuki Fukushima, Yorihiko Matsumoto, Yuka Eura, Koichi Kokame, Shigeki Miyata, Sachi Matsuda, Hiroki Mochizuki, Keiichiro Iwasaki, Yuki Kimura, Koichi Toda, Yuto Kumai, Kensuke Kuroda, Takuya Watanabe, Masanobu Yanase, Junjiro Kobayashi, Norihide Fukushima

Journal of Artificial Organs 22 ( 4 ) 334 - 337 2019.12

Role of Gallium-SPECT-CT in the Management of Patients With Ventricular Assist Device-Specific Percutaneous Driveline Infection

Yuki Kimura, Osamu Seguchi, Hiroki Mochizuki, Keiichiro Iwasaki, Koichi Toda, Yuto Kumai, Kensuke Kuroda, Seiko Nakajima, Emi Tateishi, Takuya Watanabe, Yorihiko Matsumoto, Satsuki Fukushima, Keisuke Kiso, Masanobu Yanase, Tomoyuki Fujita, Junjiro Kobayashi, Norihide Fukushima

Journal of Cardiac Failure 25 ( 10 ) 795 - 802 2019.10

Left ventricular assist device implantation in an adult male with Danon disease

Kensuke Kuroda, Osamu Seguchi, Hideo Matama, Yuki Kimura, Keiichiro Iwasaki, Koichi Toda, Noriko Kikuchi, Yuto Kumai, Seiko Nakajima, Yorihiko Matsumoto, Takuya Watanabe, Masanobu Yanase, Satsuki Fukushima, Fujita Tomoyuki, Junjiro Kobayashi, Norihide Fukushima

Journal of Cardiology Cases 20 ( 3 ) 106 - 109 2019.9

心臓サルコイドーシスに対する心移植の経験

吉竹功央一, 姉川英志, 筋野容守, 八木信一郎, 望月宏樹, 岩崎慶一郎, 渡邉琢也, 黒田健輔, 中島誠子, 簗瀬正伸, 福嶌五月, 藤田知之, 小林順二郎, 福嶌教偉

移植 54 ( 総会臨時 ) 314 - 314 2019.9

De novo malignancy in heart transplant recipients: A single center experience in Japan

Yuki Kimura, Masanobu Yanase, Hiroki Mochizuki, Keiichiro Iwasaki, Koichi Toda, Sachi Matsuda, Hiromi Takenaka, Yuto Kumai, Kensuke Kuroda, Seiko Nakajima, Takuya Watanabe, Megumi Morii Ikura, Kyoichi Wada, Yorihiko Matsumoto, Osamu Seguchi, Satsuki Fukushima, Tomoyuki Fujita, Junjiro Kobayashi, Norihide Fukushima

Journal of Cardiology 73 ( 3 ) 255 - 261 2019.3

Asymptomatic versus Symptomatic Patients with Severe Aortic Stenosis

Norio Kanamori, Tomohiko Taniguchi, Takeshi Morimoto, Hiroki Shiomi, Kenji Ando, Koichiro Murata, Takeshi Kitai, Yuichi Kawase, Chisato Izumi, Makoto Miyake, Hirokazu Mitsuoka, Masashi Kato, Yutaka Hirano, Shintaro Matsuda, Kazuya Nagao, Tsukasa Inada, Hiroshi Mabuchi, Yasuyo Takeuchi, Keiichiro Yamane, Mamoru Toyofuku, Mitsuru Ishii, Eri Minamino-Muta, Takao Kato, Moriaki Inoko, Tomoyuki Ikeda, Akihiro Komasa, Katsuhisa Ishii, Kozo Hotta, Nobuya Higashitani, Yoshihiro Kato, Yasutaka Inuzuka, Chiyo Maeda, Toshikazu Jinnai, Yuko Morikami, Naritatsu Saito, Kenji Minatoya, Takeshi Aoyama, Takeshi Kimura

Scientific Reports 8 ( 1 ) 2018.12

植込型補助人工心臓患者の体重増加が心臓移植時に及ぼす影響について

望月宏樹, 岩崎慶一朗, 木村祐樹, 戸田紘一, 熊井優人, 黒田健輔, 中島誠子, 渡邉琢也, 瀬口理, 簗瀬正伸, 藤田知之, 小林順二郎, 福嶌教偉

移植 53 ( 4-5 ) 312 - 313 2018.12

Impact of Coronary Artery Calcification in the Donor Heart on Transmitted Coronary Artery Disease in Heart Transplant Recipients

Yuki Kimura, Osamu Seguchi, Keiichiro Iwasaki, Koichi Toda, Noriko Kikuchi, Sachi Matsuda, Yuto Kumai, Kensuke Kuroda, Kyoichi Wada, Yorihiko Matsumoto, Satsuki Fukushima, Masanobu Yanase, Tomoyuki Fujita, Junjiro Kobayashi, Norihide Fukushima

Circulation Journal 82 ( 12 ) 3021 - 3028 2018.11

心臓移植術後急性期の高心拍出は心臓移植後痙攣発作の独立予測因子である

岩崎慶一朗, 木村祐樹, 戸田紘一, 熊井優人, 黒田健輔, 中島誠子, 渡邉琢也, 瀬口理, 簗瀬正伸, 藤田知之, 小林順二郎, 福嶌教偉

移植 53 ( 総会臨時 ) 348 - 348 2018.9

Prognostic Impact of Left Ventricular Ejection Fraction in Patients With Severe Aortic Stenosis

Tomohiko Taniguchi, Takeshi Morimoto, Hiroki Shiomi, Kenji Ando, Norio Kanamori, Koichiro Murata, Takeshi Kitai, Kazushige Kadota, Chisato Izumi, Kenji Nakatsuma, Tomoki Sasa, Hirotoshi Watanabe, Yasuhide Kuwabara, Takeru Makiyama, Koh Ono, Satoshi Shizuta, Takao Kato, Naritatsu Saito, Kenji Minatoya, Takeshi Kimura, Takeshi Kimura, Tomohiko Taniguchi, Hiroki Shiomi, Naritatsu Saito, Masao Imai, Junichi Tazaki, Toshiaki Toyota, Hirooki Higami, Tetsuma Kawaji, Kenji Ando, Shinichi Shirai, Kengo Kourai, Takeshi Arita, Shiro Miura, Kyohei Yamaji, Takeshi Aoyama, Norio Kanamori, Tomoya Onodera, Koichiro Murata, Yutaka Furukawa, Takeshi Kitai, Kitae Kim, Kazushige Kadota, Yuichi Kawase, Keiichiro Iwasaki, Hiroshi Miyawaki, Ayumi Misao, Akimune Kuwayama, Masanobu Ohya, Takenobu Shimada, Hidewo Amano, Yoshihisa Nakagawa, Chisato Izumi, Makoto Miyake, Masashi Amano, Yusuke Takahashi, Yusuke Yoshikawa, Shunsuke Nishimura, Maiko Kuroda, Manabu Shirotani, Hirokazu Mitsuoka, Shinji Miki, Tetsu Mizoguchi, Masashi Kato, Takafumi Yokomatsu, Akihiro Kushiyama, Hidenori Yaku, Toshimitsu Watanabe, Shunichi Miyazaki, Yutaka Hirano, Mitsuo Matsuda, Shintaro Matsuda, Sachiko Sugioka, Tsukasa Inada, Kazuya Nagao, Naoki Takahashi, Kohei Fukuchi, Tomoyuki Murakami, Hiroshi Mabuchi, Teruki Takeda, Tomoko Sakaguchi, Keiko Maeda, Masayuki Yamaji, Motoyoshi Maenaka, Yutaka Tadano, Hiroki Sakamoto, Yasuyo Takeuchi, Makoto Motooka, Ryusuke Nishikawa, Hiroshi Eizawa, Keiichiro Yamane, Mitsunori Kawato, Minako Kinoshita, Kenji Aida, Takashi Tamura, Mamoru Toyofuku, Kousuke Takahashi, Euihong Ko, Masaharu Akao, Mitsuru Ishii, Nobutoyo Masunaga, Hisashi Ogawa, Moritake Iguchi, Takashi Unoki, Kensuke Takabayashi, Yasuhiro Hamatani, Yugo Yamashita, Moriaki Inoko, Eri Minamino-Muta, Takao Kato, Yoshihiro Himura, Tomoyuki Ikeda, Katsuhisa Ishii, Akihiro Komasa, Yukihito Sato, Kozo Hotta, Shuhei Tsuji, Yuji Hiraoka, Nobuya Higashitani, Ichiro Kouchi, Yoshihiro Kato, Shigeru Ikeguchi, Yasutaka Inuzuka, Soji Nishio, Jyunya Seki, Eiji Shinoda, Miho Yamada, Akira Kawamoto, Chiyo Maeda, Takashi Konishi, Toshikazu Jinnai, Kouji Sogabe, Michiya Tachiiri, Yukiko Matsumura, Chihiro Ota, Shoji Kitaguchi, Yuko Morikami, Ryuzo Sakata, Kenji Minakata, Kenji Minatoya, Michiya Hanyu, Fumio Yamazaki, Tadaaki Koyama, Tatsuhiko Komiya, Kazuo Yamanaka, Noboru Nishiwaki, Hiroyuki Nakajima, Motoaki Ohnaka, Hiroaki Osada, Katsuaki Meshii, Toshihiko Saga, Masahiko Onoe, Shogo Nakayama, Genichi Sakaguchi, Atsushi Iwakura, Kotaro Shiraga, Koji Ueyama, Keiichi Fujiwara, Atsushi Fukumoto, Masaki Park, Junichiro Nishizawa, Mitsuru Kitano

JACC: Cardiovascular Interventions 11 ( 2 ) 145 - 157 2018.1

Prognostic Impact of Peak Aortic Jet Velocity in Conservatively Managed Patients With Severe Aortic Stenosis: An Observation From the CURRENT AS Registry

Kenji Nakatsuma, Tomohiko Taniguchi, Takeshi Morimoto, Hiroki Shiomi, Kenji Ando, Norio Kanamori, Koichiro Murata, Takeshi Kitai, Yuichi Kawase, Chisato Izumi, Makoto Miyake, Hirokazu Mitsuoka, Masashi Kato, Yutaka Hirano, Shintaro Matsuda, Tsukasa Inada, Kazuya Nagao, Tomoyuki Murakami, Yasuyo Takeuchi, Keiichiro Yamane, Mamoru Toyofuku, Mitsuru Ishii, Eri Minamino‐Muta, Takao Kato, Moriaki Inoko, Tomoyuki Ikeda, Akihiro Komasa, Katsuhisa Ishii, Kozo Hotta, Nobuya Higashitani, Yoshihiro Kato, Yasutaka Inuzuka, Chiyo Maeda, Toshikazu Jinnai, Yuko Morikami, Naritatsu Saito, Kenji Minatoya, Takeshi Kimura, Masao Imai, Junichi Tazaki, Toshiaki Toyota, Hirooki Higami, Tetsuma Kawaji, Shinichi Shirai, Kengo Korai, Takeshi Arita, Shiro Miura, Kyohei Yamaji, Kitae Kim, Keiichiro Iwasaki, Hiroshi Miyawaki, Ayumi Misao, Akimune Kuwayama, Masanobu Ohya, Takenobu Shimada, Hidewo Amano, Masashi Amano, Yusuke Takahashi, Yusuke Yoshikawa, Shunsuke Nishimura, Maiko Kuroda, Tetsu Mizoguchi, Takafumi Yokomatsu, Akihiro Kushiyama, Hidenori Yaku, Toshimitsu Watanabe, Sachiko Sugioka, Naoki Takahashi, Kohei Fukuchi, Hiroshi Mabuchi, Teruki Takeda, Tomoko Sakaguchi, Masayuki Yamaji, Motoyoshi Maenaka, Yutaka Tadano, Makoto Motooka, Ryusuke Nishikawa, Mitsunori Kawato, Minako Kinoshita, Kenji Aida, Kousuke Takahashi, Euihong Ko, Nobutoyo Masunaga, Hisashi Ogawa, Moritake Iguchi, Takashi Unoki, Kensuke Takabayashi, Yasuhiro Hamatani, Yugo Yamashita, Shuhei Tsuji, Soji Nishio, Jyunya Seki, Miho Yamada, Akira Kawamoto, Kouji Sogabe, Michiya Tachiiri, Yukiko Matsumura, Chihiro Ota, Ryuzo Sakata, Kenji Minakata, Michiya Hanyu, Fumio Yamazaki, Tadaaki Koyama, Tatsuhiko Komiya, Kazuo Yamanaka, Noboru Nishiwaki, Motoaki Ohnaka, Hiroaki Osada, Katsuaki Meshii, Toshihiko Saga, Hitoshi Kitayama, Shogo Nakayama, Genichi Sakaguchi, Atsushi Iwakura, Kotaro Shiraga, Koji Ueyama, Keiichi Fujiwara, Atsushi Fukumoto, Senri Miwa, Junichiro Nishizawa, Mitsuru Kitano, Hirotoshi Watanabe, Tomoki Sasa

Journal of the American Heart Association 6 ( 7 ) 2017.7

Publishing type：Research paper (scientific journal) Publisher：Ovid Technologies (Wolters Kluwer Health)

Background

 There are limited data regarding the risk stratification based on peak aortic jet velocity (Vmax) in patients with severe aortic stenosis ( AS ).

 Methods and Results

 Among 3815 consecutive patients with severe AS enrolled in the CURRENT AS (Contemporary Outcomes After Surgery and Medical Treatment in Patients With Severe Aortic Stenosis) registry, the study population consisted of 1075 conservatively managed patients with Vmax ≥4.0 m/s and left ventricular ejection fraction ≥50%. The study patients were subdivided into 3 groups based on Vmax (group 1, 4.0 ≤ Vmax <4.5 m/s, N=550; group 2, 4.5 ≤ Vmax <5 m/s, N=279; and group 3, Vmax ≥5 m/s, N=246). Cumulative 5‐year incidence of AS ‐related events (aortic valve–related death or heart failure hospitalization) was incrementally higher with increasing Vmax (entire population; 38.0%, 49.4%, and 62.8%, P <0.001; symptomatic patients; 55.7%, 60.9%, and 72.2%, P =0.008; and asymptomatic patients; 29.4%, 38.9%, and 47.7%, P =0.005). After adjusting for confounders, the excess risk of group 2 and group 3 relative to group 1 for AS ‐related events remained significant (hazard ratio, 1.39; 95% CI , 1.07–1.81; P =0.02, and hazard ratio, 1.53; 95% CI , 1.17–2.00; P =0.002, respectively). The effect size of group 3 relative to group 1 for AS ‐related events in asymptomatic patients (N=479) was similar to that in symptomatic patients (N=596; hazard ratio, 1.59; 95% CI , 1.01–2.52; P =0.047, and hazard ratio, 1.67; 95% CI , 1.16–2.40, P =0.008, respectively), and there was no significant overall interaction between the symptomatic status and the effect of the Vmax categories on AS ‐related events (interaction, P =0.88).

 Conclusions

 In conservatively managed severe AS patients with preserved left ventricular ejection fraction, increasing Vmax was associated with incrementally higher risk for AS ‐related events. However, the cumulative 5‐year incidence of the AS ‐related events remained very high even in asymptomatic patients with less greater Vmax.

DOI： 10.1161/jaha.117.005524

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Severe Aortic Stenosis in Dialysis Patients

Yuichi Kawase, Tomohiko Taniguchi, Takeshi Morimoto, Kazushige Kadota, Keiichiro Iwasaki, Akimune Kuwayama, Masanobu Ohya, Takenobu Shimada, Hidewo Amano, Takeshi Maruo, Yasushi Fuku, Chisato Izumi, Takeshi Kitai, Naritatsu Saito, Eri Minamino‐Muta, Takao Kato, Tsukasa Inada, Moriaki Inoko, Katsuhisa Ishii, Tatsuhiko Komiya, Michiya Hanyu, Kenji Minatoya, Takeshi Kimura

Journal of the American Heart Association 6 ( 7 ) 2017.7

Publishing type：Research paper (scientific journal) Publisher：Ovid Technologies (Wolters Kluwer Health)

Background

Characteristics and prognosis of hemodialysis patients with severe aortic stenosis have not yet been well defined.

 Methods and Results

 The CURRENT AS (contemporary outcomes after surgery and medical treatment in patients with severe aortic stenosis) registry, a Japanese multicenter registry, enrolled 3815 consecutive patients with severe aortic stenosis. There were 405 hemodialysis patients (initial aortic valve replacement [ AVR ] group: N=135 [33.3%], and conservative group: N=270) and 3410 nonhemodialysis patients (initial AVR group: N=1062 [31.1%], and conservative group: N=2348). The median follow‐up duration after the index echocardiography was 1361 days, with 90% follow‐up rate at 2 years. The cumulative 5‐year incidence of all‐cause death was significantly higher in hemodialysis patients than in nonhemodialysis patients in both the entire cohort (71% versus 40%, P <0.001) and in the initial AVR group (63.2% versus 17.9%, P <0.001). Among hemodialysis patients, the initial AVR group as compared with the conservative group was associated with significantly lower cumulative 5‐year incidences of all‐cause death (60.6% versus 75.5%, P <0.001) and sudden death (10.2% versus 31.7%, P <0.001). Nevertheless, the rate of aortic valve procedure–related death, which predominantly occurred within 6 months of the AVR procedure, was markedly higher in the hemodialysis patients than in the nonhemodialysis patients (21.2% and 2.3%, P <0.001).

 Conclusions

 Among hemodialysis patients with severe aortic stenosis, the initial AVR strategy as compared with the conservative strategy was associated with significantly lower long‐term mortality risk, particularly the risk for sudden death, although the effect size for the survival benefit of the initial AVR strategy was smaller than that in the nonhemodialysis patients.

DOI： 10.1161/jaha.116.004961

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Induced NCX1 overexpression attenuates pressure overload-induced pathological cardiac remodelling

Yoshihiro Ujihara, Keiichiro Iwasaki, Satomi Takatsu, Ken Hashimoto, Keiji Naruse, Satoshi Mohri, Yuki Katanosaka

Cardiovascular Research 111 ( 4 ) 348 - 361 2016.9

Predictors of Worsening Renal Function in Patients With Acute Decompensated Heart Failure Treated by Low-Dose Carperitide

Yuichi Kawase, Kazushige Kadota, Takeshi Tada, Reo Hata, Keiichiro Iwasaki, Takeshi Maruo, Harumi Katoh, Kazuaki Mitsudo

Circulation Journal 80 ( 2 ) 418 - 425 2016

Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Circulation Society

Background:Predictors of worsening renal function (WRF: increase in serum creatinine ≥0.3 mg/dl from the value on admission) in patients with acute decompensated heart failure (ADHF) treated by low-dose carperitide (0.01–0.05 μg/kg/min) are unclear.Methods and Results:We retrospectively investigated predictors of WRF within the first 24 h of low-dose carperitide therapy in 205 patients (mean age, 75.6±12.1 years) hospitalized for ADHF and treated with low-dose carperitide between January 2006 and April 2014. WRF occurred in 14 patients (7%). A multivariate adjustment analysis showed that independent predictors of WRF within 24 h were hypotension (systolic blood pressure <90 mmHg) within 12 h (odds ratio, 8.7; 95% confidence interval, 2.38–35.88; P=0.0012) and serum creatinine on admission (odds ratio, 3.64; 95% confidence interval, 1.84–7.67; P=0.0003). In patients with estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m², the rate of WRF occurrence was higher in those complicated by hypotension than in those without hypotension (22.6% [7/31 patients] vs. 4.4% [5/113 patients], P=0.0041). In contrast, in patients with eGFR ≥60 ml/min/1.73 m², hypotension did not influence the occurrence of WRF (0% [0/9 patients] vs. 3.9% [2/51 patients], P=NS).Conclusions:Hypotension within 12 h and renal dysfunction on admission are independent predictors of WRF within 24 h in patients with ADHF treated by low-dose carperitide. Hypotension may not cause WRF in patients with eGFR ≥60 ml/min/1.73 m². (Circ J 2016; 80: 418–425)

DOI： 10.1253/circj.cj-15-0928

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TRPV2 is critical for the maintenance of cardiac structure and function in mice

Yuki Katanosaka, Keiichiro Iwasaki, Yoshihiro Ujihara, Satomi Takatsu, Koki Nishitsuji, Motoi Kanagawa, Atsushi Sudo, Tatsushi Toda, Kimiaki Katanosaka, Satoshi Mohri, Keiji Naruse

Nature Communications 5 ( 1 ) 2014.9

The significant role of Na+/Ca2+ exchanger 1 on local Ca2+ control beneath T-tubule membrane Reviewed

Yoshihiro Ujihara, Keiichiro Iwasaki, Satomi Takatsu, Ken Hashimoto, Keiji Naruse, Satoshi Mohri, Yuki Katanosaka

Transactions of Japanese Society for Medical and Biological Engineering 52 212 - O-213 2014.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Soc. of Med. Electronics and Biol. Engineering

Na+/Ca&lt
inf&gt
2+&lt
/inf&gt
exchanger (NCX1) is essential Ca&lt
inf&gt
2+&lt
/inf&gt
regulator of myocyte Ca&lt
inf&gt
2+&lt
/inf&gt
homeostasis and specially localized at transverse tubules (T-tubules) membrane. T-tubules are invaginations of the sarcolemma and critical for myocyte contraction, especially as the main site of excitation-contraction coupling. Therefore, T-tubule disorganization is linked to decreased contractility in heart failure, but the molecular mechanism is not clear. We analyzed the alteration of T-tubule structure and Ca&lt
inf&gt
2+&lt
/inf&gt
handling during the progression of heart failure after transverse aortic constriction (TAC)-surgery, using cardiac-specific and inducible NCX1 transgenic mice. In progression of cardiac dysfunction, sarcoplasmic reticulum Ca&lt
inf&gt
2+&lt
/inf&gt
ATPase and NCX1 activity were down-regulated before T-tubule disorganization. The inducing NCX1 overexpression after TAC-surgery prevented T-tubule disorganization and contractile dysfunction under prolonged pressure-overload, with improvement of myocyte Ca&lt
inf&gt
2+&lt
/inf&gt
handling. These results suggest that local Ca&lt
inf&gt
2+&lt
/inf&gt
control beneath the T-tubule membrane is crucial for the maintenance of myocyte structure and function, in which NCX1 has a pivotal role.

DOI： 10.11239/jsmbe.52.O-212

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The significant role of Na⁺/Ca²⁺ exchanger 1 on local Ca²⁺ control beneath T-tubule membrane

Ujihara Yoshihiro, Iwasaki Keiichiro, Takatsu Satomi, Hashimoto Ken, Naruse Keiji, Mohri Satoshi, Katanosaka Yuki

BME 52 O - 212-O-213 2014

Language：Japanese Publisher：Japanese Society for Medical and Biological Engineering

Na⁺/Ca²⁺ exchanger (NCX1) is essential Ca²⁺ regulator of myocyte Ca²⁺ homeostasis and specially localized at transverse tubules (T-tubules) membrane. T-tubules are invaginations of the sarcolemma and critical for myocyte contraction, especially as the main site of excitation-contraction coupling. Therefore, T-tubule disorganization is linked to decreased contractility in heart failure, but the molecular mechanism is not clear. We analyzed the alteration of T-tubule structure and Ca2+ handling during the progression of heart failure after transverse aortic constriction (TAC)-surgery, using cardiac-specific and inducible NCX1 transgenic mice. In progression of cardiac dysfunction, sarcoplasmic reticulum Ca²⁺ ATPase and NCX1 activity were down-regulated before T-tubule disorganization. The inducing NCX1 overexpression after TAC-surgery prevented T-tubule disorganization and contractile dysfunction under prolonged pressure-overload, with improvement of myocyte Ca²⁺ handling. These results suggest that local Ca²⁺ control beneath the T-tubule membrane is crucial for the maintenance of myocyte structure and function, in which NCX1 has a pivotal role.

DOI： 10.11239/jsmbe.52.O-212

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