Faculty Profiles - Kyohei Kin

Papers - Kyohei Kin

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SF-36 scores predict postoperative delirium after surgery for cervical spondylotic myelopathy. Reviewed International journal

Kyohei Kin, Takao Yasuhara, Yousuke Tomita, Michiari Umakoshi, Jun Morimoto, Isao Date

Journal of neurosurgery. Spine 1 - 6 2019.3

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVECervical spondylotic myelopathy (CSM) is one of the most common causes of spinal cord dysfunction. Surgery for CSM is generally effective, but postoperative delirium is a potential complication. Although there have been some studies that investigated postoperative delirium after spine surgery, no useful tool for identifying high-risk patients has been established, and it is unknown if 36-Item Short Form Health Survey (SF-36) scores can predict postoperative delirium. The objective of this study was to evaluate the correlation between preoperative SF-36 scores and postoperative delirium after surgery for CSM.METHODSSixty-seven patients who underwent surgery for CSM at the authors' institution were enrolled in this study. Medical records of these patients were retrospectively reviewed. Patient background, preoperative laboratory data, preoperative SF-36 scores, the preoperative Japanese Orthopaedic Association (JOA) score for the evaluation of cervical myelopathy, and perioperative factors were selected as potential risk factors for postoperative delirium. These factors were evaluated using univariable and multivariable logistic regression analysis.RESULTSTen patients were diagnosed with postoperative delirium. Univariable analysis revealed that the physical functioning score (p = 0.01), general health perception score (p < 0.01), and vitality score (p < 0.01) of the SF-36 were significantly lower in patients with postoperative delirium than in those without. The total number of medications was significantly higher in the delirium group compared with the no-delirium group (p = 0.02). In contrast, there were no significant differences between the delirium group and the no-delirium group in cervical JOA scores (p = 0.20). Multivariable analysis revealed that a low general health perception score was an independent risk factor for postoperative delirium (p = 0.02; odds ratio 0.810, 95% confidence interval 0.684-0.960).CONCLUSIONSSome of the SF-36 scores were significantly lower in patients with postoperative delirium than in those without. In particular, the general health perception score was independently correlated with postoperative delirium. SF-36 scores could help identify patients at high risk for postoperative delirium and aid in the development of prevention strategies.

DOI： 10.3171/2018.11.SPINE181031

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Characteristics and prognostic factors of Parkinson's disease patients with abnormal postures subjected to subthalamic nucleus deep brain stimulation. Reviewed International journal

Mihoko Okazaki, Tatsuya Sasaki, Takao Yasuhara, Masahiro Kameda, Takashi Agari, Ittetsu Kin, Ken Kuwahara, Jun Morimoto, Kyohei Kin, Michiari Umakoshi, Yousuke Tomita, Cesario V Borlongan, Isao Date

Parkinsonism & related disorders 57 44 - 49 2018.12

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: In Parkinson's disease (PD), abnormal postures are often accompanied, which interfere with rehabilitation and subsequent functional recovery. This study investigated the relationship between clinical characteristics and improvement in abnormal postures of PD patients who received subthalamic nucleus deep brain stimulation (STN-DBS). METHODS: Seventy-four PD patients were included in this study. Clinical data were analyzed using the patients' functional status at pre- and post-STN-DBS, including anteflexion vs. non-anteflexion, scoliosis vs. non-scoliosis, improved anteflexion vs. non-improved anteflexion, and improved scoliosis vs. non-improved scoliosis. RESULTS: In patients with anteflexion, UPDRS III motor score at off medication was worse than that of patients with non-anteflexion. Patients with scoliosis presented with more comorbid spinal deformity and longer disease duration than those without scoliosis. Cobb angle of patients with asymmetrical psoas major and erector spinal muscles was more than that of patients without the asymmetry. Patients with improved anteflexion after STN-DBS had thicker abdominal oblique muscle and transverse abdominal muscle than those of patients without improved anteflexion. Patients with improved scoliosis were significantly younger at PD onset than those without improvement. CONCLUSIONS: There were only a few prognostic factors recognized in patients with improved postures. The thick abdominal muscle for anteflexion and younger PD onset for scoliosis were significant factors for improvement by STN-DBS. Rehabilitation designed to maintain muscle for correct postures may contribute to the amelioration of abnormal postures by STN-DBS, although multicenter trials are needed.

DOI： 10.1016/j.parkreldis.2018.07.014

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Encapsulated stem cells ameliorate depressive-like behavior via growth factor secretion Reviewed

kyohei kin

Brain Circulation 4 ( 3 ) 128 - 132 2018.7

The Factors Affecting the Difficulty of Percutaneous Cylindrical Electrode Placement for Spinal Cord Stimulation. Reviewed International journal

Kyohei Kin, Takashi Agari, Takao Yasuhara, Yousuke Tomita, Ken Kuwahara, Ittetsu Kin, Michiari Umakoshi, Jun Morimoto, Mihoko Okazaki, Tatsuya Sasaki, Isao Date

World neurosurgery 113 e391-e398 - e398 2018.5

Spinal Extradural Arachnoid Cyst: Significance of Intrathecal Infusion after Fistula Closure. Reviewed

Michiari Umakoshi, Takao Yasuhara, Atsuhiko Toyoshima, Susumu Sasada, Akira Kusumegi, Jun Morimoto, Kyohei Kin, Yousuke Tomita, Isao Date

Acta medica Okayama 72 ( 1 ) 73 - 76 2018.2

Language：English Publishing type：Research paper (scientific journal)

The spinal extradural arachnoid cyst is a rare entity. Obtaining the correct diagnosis and detecting the fistula location are critical for providing effective treatment. A 41-year-old man had numbness in the soles of his feet for 2 years with accompanying gait disturbance, and a defecation disorder. Computed tomography myelography performed at another hospital revealed an epidural arachnoid cyst from Th11 to L2. He received a subarachnoid-cyst shunt at the rostral part of the cyst. However, his symptoms worsened and he was admitted to our hospital. Neuroradiological investigations revealed the correct location of the fistula at the level of Th12. We performed partial removal of the cyst wall with fistula closure via right hemilaminectomy of Th11 and 12. The complete closure of the fistula was confirmed by intrathecal infusion of artificial cerebrospinal fluid through the shunt tube. The shunt tube was removed with the sutures. The patient's symptoms improved, although numbness remained in his bilateral heels. There has been no recurrence in 15 months since the surgery. Fistula closure may work as a balanced therapeutic strategy for spinal extradural arachnoid cyst, and intrathecal cerebrospinal fluid infusion is useful for the confirmation of complete fistula closure.

DOI： 10.18926/AMO/55666

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Electrical Stimulation Enhances Migratory Ability of Transplanted Bone Marrow Stromal Cells in a Rodent Ischemic Stroke Model. Reviewed International journal

Jun Morimoto, Takao Yasuhara, Masahiro Kameda, Michiari Umakoshi, Ittetsu Kin, Ken Kuwahara, Kyohei Kin, Mihoko Okazaki, Hayato Takeuchi, Tatsuya Sasaki, Atsuhiko Toyoshima, Naoki Tajiri, Takashi Agari, Cesario V Borlongan, Isao Date

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 46 ( 1 ) 57 - 68 2018

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND/AIMS: Bone marrow stromal cells (BMSCs) transplantation is an important strategy for the treatment of ischemic stroke. Currently, there are no effective methods to guide BMSCs toward the targeted site. In this study, we investigated the effect of electrical stimulation on BMSCs migration in an ischemic model of rats. METHODS: Adult male Wistar rats weighing 200 to 250 g received right middle cerebral artery occlusion (MCAO) for 90 minutes. BMSCs (2.5×105 cells/ 4 µl PBS) were stereotaxically injected into the left corpus callosum at 1 day after MCAO. After BMSCs injection, a plate electrode with a diameter of 3 mm connected to an implantable electrical stimulator was placed on the right frontal epidural space and a counter electrode was placed in the extra-cranial space. Electrical stimulation at preset current (100 µA) and frequency (100 Hz) was performed for two weeks. Behavioral tests were performed at 1, 4, 8, and 15 days after MCAO using the modified Neurological Severity Score (mNSS) and cylinder test. Rats were euthanized at 15 days after MCAO for evaluation of infarction area and the migration distance and area of BMSCs found in the brain tissue. After evaluating cell migration, we proceeded to explore the mechanisms guiding these observations. MCAO rats without BMSCs transplantation were stimulated with same current and frequency. At 1 and 2 weeks after MCAO, rats were euthanized to evaluate stromal cell-derived factor 1 alpha (SDF-1α) level of brain tissues in the bilateral cortex and striatum. RESULTS: Behavioral tests at 4, 8, and 15 days after MCAO revealed that stimulation group displayed significant amelioration in mNSS and cylinder test compared to control group (p<0.05). Similarly, the infarction areas of stroke rats in stimulation group were significantly decreased compared to control group (p<0.05). Migration distance and area of transplanted BMSCs were significantly longer and wider respectively in stimulation group. An increased concentration gradient of SDF-1α in stimulation group accompanied this enhanced migration of transplanted cells. CONCLUSIONS: These results suggest that electrical stimulation enhances migratory ability of transplanted BMSCs in ischemic stroke model of rats. If we can direct the implanted BMSCs to the site of interest, it may lead to a greater therapeutic effect.

DOI： 10.1159/000488409

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Long-Term Potentiation Enhances Neuronal Differentiation in the Chronic Hypoperfusion Model of Rats. Reviewed International journal

Hayato Takeuchi, Masahiro Kameda, Takao Yasuhara, Tatsuya Sasaki, Atsuhiko Toyoshima, Jun Morimoto, Kyohei Kin, Mihoko Okazaki, Michiari Umakoshi, Ittetsu Kin, Ken Kuwahara, Yosuke Tomita, Isao Date

Frontiers in aging neuroscience 10 29 - 29 2018

Hippocampal neurogenesis of Wistar Kyoto rats is congenitally impaired and correlated with stress resistance. Reviewed International journal

Kyohei Kin, Takao Yasuhara, Masahiro Kameda, Takashi Agari, Tatsuya Sasaki, Jun Morimoto, Mihoko Okazaki, Michiari Umakoshi, Ken Kuwahara, Ittetsu Kin, Naoki Tajiri, Isao Date

Behavioural brain research 329 148 - 156 2017.6

Surgery in the Standing Position by a Surgeon with Achilles Tendon Rupture. Reviewed

Takao Yasuhara, Ken Kuwahara, Susumu Sasada, Atsuhiko Toyoshima, Jun Morimoto, Kyohei Kin, Hiroaki Manabe, Yasuyuki Miyoshi, Akira Kusumegi, Yuichi Takahashi, Kiyoshi Ito, Isao Date

Acta medica Okayama 70 ( 6 ) 493 - 496 2016.12

The Usefulness of CT-Diffusion Weighted Image Mismatch in Patients with Mild to Moderate Traumatic Brain Injury.

Kyohei Kin, Yasuhiro Ono, Takeshi Fujimori, Satoshi Kuramoto, Atsushi Katsumata, Yuji Goda, Masamitsu Kawauchi

Acta medica Okayama 70 ( 4 ) 237 - 42 2016.8

Language：English Publishing type：Research paper (scientific journal)

Traumatic brain injury (TBI) has a complex and heterogeneous pathology. It is frequently difficult to predict the neurological deterioration of patients with TBI, and unpredictable change may occur even when TBI is mild to moderate. When computed tomography (CT) findings are considered to be inconsistent with the traumatic origin or with the neurological deterioration of patients observed on admission, magnetic resonance imaging (MRI) is employed based on the standards of our ethical committee. In this retrospective study, we compared CT and diffusion weighted imaging (DWI) of patients with mild to moderate TBI in the very acute phase. When the high-intensity lesions on DWI are larger than the high-density lesions on CT images, we defined the imaging finding as a 'CT-DWI mismatch'. Between January 2010 and December 2013, 92 patients were inspected using both CT and MRI at admission, and we detected a CT-DWI mismatch in 35 patients. CT-DWI mismatch was 92.6% (95% confidence interval 79.8-97.9) sensitive and 84.6% (95% confidence interval 79.3-86.3) specific for the prediction of enlargement of the hemorrhagic lesions on repeat CT. CT-DWI mismatch is considered to be useful as one of the predictors of the enlargement of hemorrhagic lesions in patients with mild to moderate TBI.

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脳神経外傷のBasic Research リハビリテーションが神経保護・神経新生に与える影響

安原隆雄, 田尻直輝, 亀田雅博, 大熊佑, 豊嶋敦彦, 竹内勇人, 守本純, 金恭平, 上利崇, 菱川朋人, 伊達勲

日本脳神経外傷学会プログラム・抄録集 39回 71 - 71 2016.2

[A Case of Transorbital Penetrating Brain Injury Caused by a Steel Wire Entirely Embedded in the Brain Parenchyma]. Reviewed

Kyohei Kin, Yasuhiro Ono, Takeshi Fujimori, Satoshi Kuramoto, Atsushi Katsumata, Yuji Goda, Masamitsu Kawauchi

No shinkei geka. Neurological surgery 43 ( 10 ) 921 - 6 2015.10

[A case of intracranial primary leptomeningeal lymphoma]. Reviewed

Kyohei Kin, Yasuhiro Ono, Yoshio Hisamatsu, Satoshi Kuramoto, Atsushi Katsumata, Hideyuki Yoshida, Masamitsu Kawauchi, Satoko Nakamura

No shinkei geka. Neurological surgery 42 ( 3 ) 233 - 9 2014.3

後方1/4離断術が奏功した大田原症候群の一例

上利崇, 近藤聡彦, 秋山倫之, 林裕美子, 桃木恵美子, 井上拓志, 岡牧郎, 小林勝弘, 佐々木達也, 金恭平, 伊達勲

てんかん研究 31 ( 1 ) 90 - 91 2013.6

経動脈的および経静脈的根治的塞栓術を行ったKlippel-Trenaunay-Weber症候群に合併する脊髄辺縁部動静脈瘻の1例

金恭平, 徳永浩司, 春間純, 菱川朋人, 眞鍋博明, 三好康之, 杉生憲志, 伊達勲

JNET: Journal of Neuroendovascular Therapy 6 ( 5 ) 417 - 417 2012.11

BDNF-secreting capsule exerts neuroprotective effects on epilepsy model of rats Reviewed

Satoshi Kuramoto, Takao Yasuhara, Takashi Agari, Akihiko Kondo, Meng Jing, Yoichiro Kikuchi, Aiko Shinko, Takaaki Wakamori, Masahiro Kameda, Feifei Wang, Kyohei Kin, Satoru Edahiro, Yasuyuki Miyoshi, Isao Date

BRAIN RESEARCH 1368 281 - 289 2011.1

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