Catalytic Enantioselective Intramolecular Oxa-Michael Reaction to α,β-Unsaturated Esters and Amides

Guanglong Su, Michele Formica, Ken Yamazaki, Trevor A. Hamlin, Darren J. Dixon

Journal of the American Chemical Society   2023.6

Bifunctional Iminophosphorane‐Catalyzed Enantioselective Nitroalkane Addition to Unactivated α,β‐Unsaturated Esters**

Daniel Rozsar, Alistair J. M. Farley, Iain McLauchlan, Benjamin D. A. Shennan, Ken Yamazaki, Darren J. Dixon

Angewandte Chemie   2023.5

Catalytic enantioselective nucleophilic desymmetrization of phosphonate esters

Michele Formica, Tatiana Rogova, Heyao Shi, Naoto Sahara, Branislav Ferko, Alistair J. M. Farley, Kirsten E. Christensen, Fernanda Duarte, Ken Yamazaki, Darren J. Dixon

Nature Chemistry   2023.5

Enantioselective Total Synthesis of (−)-Himalensine A via a Palladium and 4-Hydroxyproline Co-catalyzed Desymmetrization of Vinyl-bromide-tethered Cyclohexanones

Roman Kučera, Sam R. Ellis, Ken Yamazaki, Jack Hayward Cooke, Nikita Chekshin, Kirsten E. Christensen, Trevor A. Hamlin, Darren J. Dixon

Journal of the American Chemical Society   2023.3

Difluoroalkylation of Tertiary Amides and Lactams by an Iridium-Catalyzed Reductive Reformatsky Reaction

Phillip Biallas, Ken Yamazaki, Darren J. Dixon

Organic Letters   24 ( 10 )   2002 - 2007   2022.3

A New Organocatalytic Desymmetrization Reaction Enables the Enantioselective Total Synthesis of Madangamine E

Shinya Shiomi, Benjamin D. A. Shennan, Ken Yamazaki, Ángel L. Fuentes de Arriba, Dhananjayan Vasu, Trevor A. Hamlin, Darren J. Dixon

Journal of the American Chemical Society   2022.1

Palladium-Catalyzed Site-Selective [5 + 1] Annulation of Aromatic Amides with Alkenes: Acceleration of β-Hydride Elimination by Maleic Anhydride from Palladacycle

Qiyuan He, Ken Yamazaki, Yusuke Ano, Naoto Chatani

ACS Catalysis   12 ( 2 )   1595 - 1600   2022.1

Bifunctional Iminophosphorane-Catalyzed Enantioselective Sulfa-Michael Addition to Unactivated α,β-Unsaturated Amides

Daniel Rozsar, Michele Formica, Ken Yamazaki, Trevor A. Hamlin, Darren J. Dixon

Journal of the American Chemical Society   2022.1

Origin of the Enhanced Reactivity in the ortho C–H Borylation of Benzaldehydes with BBr3

Ken Yamazaki, Supriya Rej, Yusuke Ano, Naoto Chatani

Organic Letters   2022.1

Double 1,2-Migration of Bromine and Silicon in Directed C–H Alkynylation Reactions with Silyl-Substituted Alkynyl Bromides through an Iridium Vinylidene Intermediate

Ken Yamazaki, Sanjit K. Mahato, Yusuke Ano, Naoto Chatani

Organometallics   2022.1

An Unusual Perpendicular Metallacycle Intermediate is the Origin of Branch Selectivity in the Rh(II)-Catalyzed C–H Alkylation of Aryl Sulfonamides with Vinylsilanes

Ken Yamazaki, Supriya Rej, Yusuke Ano, Naoto Chatani

Organometallics   2021.12

Switchable, Reagent‐Controlled Diastereodivergent Photocatalytic Carbocyclisation of Imine‐Derived α‐Amino Radicals

J. Andrew P. Maitland, Jamie A. Leitch, Ken Yamazaki, Kirsten E. Christensen, Doyle J. Cassar, Trevor A. Hamlin, Darren J. Dixon

Angewandte Chemie International Edition   60 ( 45 )   24116 - 24123   2021.11

Mechanism and Origins of Regiochemical Control in Rh(III)-Catalyzed Oxidative C–H Alkenylation and Coupling Sequence of Unprotected 1-Naphthylamines with α,β-Unsaturated Esters

Ken Yamazaki, Supriya Rej, Yusuke Ano, Naoto Chatani

Organometallics   2021.5

Iridium(III)-Catalyzed Branch-Selective C–H Alkenylation of Aniline Derivatives with Alkenes

Shrikant M. Khake, Ken Yamazaki, Yusuke Ano, Naoto Chatani

ACS Catalysis   11 ( 9 )   5463 - 5471   2021.5

A General Pyrrolidine Synthesis via Iridium-Catalyzed Reductive Azomethine Ylide Generation from Tertiary Amides & Lactams

Ken Yamazaki, Pablo Gabriel, Graziano Di Carmine, Julia Pedroni, Mirxan Farizyan, Trevor Hamlin, Darren J. Dixon

ACS Catalysis   11 ( 12 )   7489 - 7497   2021.1

A bifunctional iminophosphorane squaramide catalyzed enantioselective synthesis of hydroquinazolines via intramolecular aza-Michael reaction to α,β-unsaturated esters

Guanglong Su, Connor J. Thomson, Ken Yamazaki, Daniel Rozsar, Kirsten E. Christensen, Trevor A. Hamlin, Darren J. Dixon

Chemical Science   2021

Dual catalytic enantioselective desymmetrization of allene-tethered cyclohexanones

Zhang, L., Yamazaki, K., Leitch, J.A., Manzano, R., Atkinson, V.A.M., Hamlin, T.A., Dixon, D.J.

Chemical Science   11 ( 28 )   2020

Catalytic Reductive Functionalization of Tertiary Amides using Vaska's Complex: Synthesis of Complex Tertiary Amine Building Blocks and Natural Products

Matheau-Raven, D., Gabriel, P., Leitch, J.A., Almehmadi, Y.A., Yamazaki, K., Dixon, D.J.

ACS Catalysis   10 ( 15 )   2020

Nickel-catalyzed oxidative C-H/N-H annulation of N-heteroaromatic compounds with alkynes

Obata, A., Sasagawa, A., Yamazaki, K., Ano, Y., Chatani, N.

Chemical Science   10 ( 11 )   2019

Nickel-catalyzed reductive defunctionalization of esters in the absence of an external reductant: Activation of C-O bonds

Iyori, Y., Takahashi, K., Yamazaki, K., Ano, Y., Chatani, N.

Chemical Communications   55 ( 90 )   2019

Computational Mechanistic Study on the Nickel-Catalyzed C-H/N-H Oxidative Annulation of Aromatic Amides with Alkynes: The Role of the Nickel (0) Ate Complex

Yamazaki, K., Obata, A., Sasagawa, A., Ano, Y., Chatani, N.

Organometallics   38 ( 2 )   2019

Rhodium-Catalyzed Alkylation of C−H Bonds in Aromatic Amides with Non-activated 1-Alkenes: The Possible Generation of Carbene Intermediates from Alkenes

Yamaguchi, T., Natsui, S., Shibata, K., Yamazaki, K., Rej, S., Ano, Y., Chatani, N.

Chemistry - A European Journal   25 ( 28 )   2019

A computational study of cobalt-catalyzed C-H iodination reactions using a bidentate directing group with molecular iodine

Yamazaki, K., Kommagalla, Y., Ano, Y., Chatani, N.

Organic Chemistry Frontiers   6 ( 4 )   2019

Cobalt(II)-catalyzed chelation-assisted C-H iodination of aromatic amides with I<inf>2</inf>

Kommagalla, Y., Yamazaki, K., Yamaguchi, T., Chatani, N.

Chemical Communications   54 ( 11 )   2018

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