Updated on 2024/01/31

写真a

 
SHINNO Yasuo
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Assistant Professor
Position
Assistant Professor
External link

Degree

  • Doctor (Dental) ( Okayama University )

Research Interests

  • Regenerative Dentistry

  • Tissue Engineering

  • 組織工学

  • Esthetic Dentistry

  • 審美歯科

  • 再生歯学

Research Areas

  • Life Science / Conservative dentistry

Research History

  • - 岡山大学医歯薬学総合研究科 助教

    2005

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  • - Assistant Professor,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University

    2005

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Papers

  • 新規自己接着性コンポジットレジンの象牙質微小引張接着強さの評価

    横山 章人, 大原 直子, 高橋 圭, 松崎 久美子, 神農 泰生, 山路 公造, 吉山 昌宏

    特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集   158回   53 - 53   2023.5

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    Language：Japanese   Publisher：(NPO)日本歯科保存学会  

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  • 漂白歯面変化のSS-OCT評価

    神農 泰生, 島田 康史, 松崎 久美子, 横山 章人, Sadr Alireza, 角 保徳, 田上 順次, 吉山 昌宏

    日本歯科保存学雑誌   64 ( 4 )   265 - 270   2021.8

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    Language：Japanese   Publisher：(NPO)日本歯科保存学会  

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  • Assessment of Demineralization Inhibition Effects of Dentin Desensitizers Using Swept-Source Optical Coherence Tomography. International journal

    Kumiko Matsuzaki, Yasushi Shimada, Yasuo Shinno, Serina Ono, Kozo Yamaji, Naoko Ohara, Alireza Sadr, Yasunori Sumi, Junji Tagami, Masahiro Yoshiyama

    Materials (Basel, Switzerland)   14 ( 8 )   2021.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    The purpose of this study was to evaluate the mechanism of action and the inhibiting effects of two types of desensitizers against dentin demineralization using pre-demineralized hypersensitivity tooth model in vitro. In this study, we confirmed that a hypersensitivity tooth model from our preliminary experiment could be prepared by immersing dentin discs in an acetic acid-based solution with pH 5.0 for three days. Dentin discs with three days of demineralization were prepared and applied by one of the desensitizers containing calcium fluoro-alumino-silicate glass (Nanoseal, NS) or fluoro-zinc-silicate glass (Caredyne Shield, CS), followed by an additional three days of demineralization. Dentin discs for three days of demineralization (de3) and six days of demineralization (de6) without the desensitizers were also prepared. The dentin discs after the experimental protocol were scanned using swept-source optical coherence tomography (SS-OCT) to image the cross-sectional (2D) view of the samples and evaluate the SS-OCT signal. The signal intensity profiles of SS-OCT from the region of interest of 300, 500, and 700 µm in depth were obtained to calculate the integrated signal intensity and signal attenuation coefficient. The morphological differences and remaining chemical elements of the dentin discs were also analyzed using scanning electron microscopy and energy-dispersive X-ray spectroscopy. SS-OCT images of CS and NS groups showed no obvious differences between the groups. However, SS-OCT signal profiles for both the CS and NS groups showed smaller attenuation coefficients and larger integrated signal intensities than those of the de6 group. Reactional deposits of the desensitizers even after the additional three days of demineralization were observed on the dentin surface in NS group, whereas remnants containing Zn were detected within the dentinal tubules in CS group. Consequently, both CS and NS groups showed inhibition effects against the additional three days of demineralization in this study. Our findings demonstrate that SS-OCT signal analysis can be used to monitor the dentin demineralization and inhibition effects of desensitizers against dentin demineralization in vitro.

    DOI： 10.3390/ma14081876

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  • Color Matching Evaluation Using the Visual Analog Scale

    Serina ONO, Masahiro YOSHIYAMA, Naoko OHARA, Kumiko MATSUZAKI, Kazuhiko SHIBUYA, Akihito YOKOYAMA, Kei TAKAHASHI, Yasuo SHINNO, Kozo YAMAJI, Yasushi SHIMADA

    The Japanese Journal of Conservative Dentistry   63 ( 1 )   30 - 37   2020

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    Language：Japanese   Publisher：The Japanese Society of Conservative Dentistry  

    <p> Purpose: Recently, the application of composite resin restorations has expanded. Although chromatic studies of composite resins have progressed, color differences measured by colorimeters and visual color evaluation do not always match. The aim of this study was to establish a method of evaluating the visual color of composite resins by using the visual analog scale (VAS), which evaluates subjective data as a continuous variable, and to examine its validity.</p><p> Method: One structural color composite resin (experimental resin : ECM-001) and three commercial composite resins of shade A3 were used in this study. Class Ⅴ and class Ⅲ cavities were prepared in artificial maxillary central incisors of four shades (A1, A2, A3, and A3.5) and each composite resin was filled and its color matching was evaluated on a black-and-white background using VAS. The correlation between VAS value and visual evaluation was analyzed. The color matching of teeth and composite resin were statistically analyzed using one-way analysis of variance and Tukey's HSD test (p<0.05). Background differences in the same sample were analyzed by the t-test (p<0.05).</p><p> Results: In the Class Ⅴ restoration, ECM-001 showed better color matching than other composite resins. In the Class Ⅲ restoration, ECM-001 showed excellent color matching with a wide range of teeth shades on the white background. The VAS values of the other composite resins were higher on the black background than on the white background. However, the VAS value of ECM-001 on the black background tended to decrease. Because the evaluation of VAS color matching by evaluators showed the same tendency, the VAS value reflects information that can be recognized by visual observation. It is suggested that the evaluation of VAS value correlates with visual evaluation.</p><p> Conclusion: It is suggested that the evaluation of color matching of composite resin restorations using VAS is useful for structural color composite resins, providing a new method of visually evaluating composite resin restorations.</p>

    DOI： 10.11471/shikahozon.63.30

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  • 垂直歯根破折歯を口腔外接着再植法にて保存した症例.

    大原 直子, 田中 久美子, 垣内 伸子, 星加 知宏, 高橋 圭, 神農 泰生, 伊澤 俊次, 山路 公造, 西谷 佳浩, 吉山 昌宏

    岡山市学会雑誌   33 ( 1 )   7 - 11   2014

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  • Tooth Wearに対してコンポジットレジンによる審美修復を行った症例.

    田中 久美子, 徳善 英紀, 大原 直子, 星加 知宏, 高橋 圭, 神農 泰生, 伊澤 俊次, 山路 公造, 西谷 佳浩, 吉山 昌宏

    岡山市学会雑誌   33 ( 1 )   1 - 5   2014

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  • 嚥下障害を有する岡山大学病院頭頸部がんセンターの患者に対して厳重なラバーダム装着がコンポジットレジン修復に有効であった症例

    田中久美子, 遠藤 梓, 渋谷和彦, 佐々木禎子, 三浦留美, 神農泰生, 西谷佳浩, 水川展吉, 吉山昌宏

    岡山歯学会雑誌   32 ( 2 )   65 - 70   2013

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  • 各種漂白剤処理後のエナメル質に対する接着性の検討.

    岸本麻実, 神農泰生, 穴吹優佳, 中田 貴, 田中久美子, 西谷佳浩, 吉山昌宏

    日本歯科保存学雑誌   53 ( 6 )   585 - 591   2010

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  • XPS analysis of the dentin irradiated by Er:YAG laser

    Masanori Omae, Yasuo Shinnou, Kumiko Tanaka, Tomoko Abo, Takashi Nakata, Koichiro Suzuki, Yoshinori Hatsuoka, Naohiro Iwata, Kazushi Yoshikawa, Yoshihiro Nishitani, Kazuyo Yamamoto, Masahiro Yoshiyama

    DENTAL MATERIALS JOURNAL   28 ( 4 )   471 - 476   2009.7

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：JAPANESE SOC DENTAL MATERIALS DEVICES  

    The aim of this study was to investigate the effect of Er:YAG laser irradiation on human dentin surface using X-ray photoelectron spectroscopy (XPS). 10 human dentin disks were prepared from extracted human molars for XPS analysis. These specimens were divided into two groups of five: a control group and group that were irradiated by an Er:YAG laser beam (1.00 mJ, 1Hz). All specimens were analyzed by XPS over a wide scanning range and narrow scanning ranges. The Ca/P ratio was calculated from the XPS results.
    In the results, the binding energies of Ca, P, and N in the laser-irradiated group were higher than those in the control group. The Ca/P ratio of the Er:YAG laser irradiated group (1.24 +/- 0.05) was significantly lower than that of the control group (1.52 +/- 0.16). This study showed that Er:YAG laser irradiation decreased Ca/P ratio and denatured the collagen of human dentin.

    DOI： 10.4012/dmj.28.471

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  • Dentin Regeneration by the Differentiated Human Bone Marrow Mesenchymal Stem Cells

    IZAWA Shunji, YAMAJI Kozo, HOSHIKA Tomohiro, NAKATA Takashi, SHINNO Yasuo, NISHITANI Yoshihiro, YOSHIYAMA Masahiro

    Journal of the Japanese Association of Regenerative Dentistry   7 ( 1 )   47 - 55   2009

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    Language：Japanese   Publisher：Japanese Association of Regenerative Dentistry  

    Dentin regeneration to the lost dentin is the supreme therapy to keep functionality, aesthetics and so forth in operative dentistry. In 2006, we demonstrated the human bone marrow mesenchymal stem cells (hMSCs) differentiated into odontoblast by the stimulation of Emdogain Gel and TNF-&alpha; set. In 2008, we tried to demonstrate odontoblast that differentiated from hMSCs generate dentin under the artificially synthesized appropriate scaffold and molecular signal in vitro. As a result, the differentiated cell tissue tested positive for osteocalcin by fluorescence antibody method and enzyme antibody technique and positive for calcium compounds with the alizarin red S staining. In addition, we detected the dentin-like tissue outside the cell walls by phase contrast microscopy. These results suggested that hMSCs differentiate into odontoblast and generate dentin using Emdogain Gel and TNF-&alpha; set and peptide hydrogel.

    DOI： 10.11223/jard.7.47

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  • Bond Strength and Bio-Compatibility of Experimental Mineralization Accelerating Adhesives Added Collagen Immobilized Poly Ethylene-co-Vinyl Alcohol (EVA+C)

    SHINNO Yasuo, KISHIMOTO Mami, ANABUKI Yuka, YAMAJI Kozo, NISHITANI Yoshihiro, TANAKA Toru, SANO Hidehiko, YOSHIYAMA Masahiro

    Journal of the Japanese Association of Regenerative Dentistry   7 ( 1 )   56 - 63   2009

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    Language：Japanese   Publisher：Japanese Association of Regenerative Dentistry  

    The mineralization accelerating adhesion materials that added EVA+C (RMSB) were produced experimentally, and we studied it about a bond strength and the biocompatibility. As a result, bond strength decreased with increase of the EVA+C addition ratio. But the level of the decrease was inhibited when SBP30 was treated. The RMSB group showed a tendency to growth similar to Control at the early phase, and cell count was higher than an SB (Superbond) at high ratio of EVA+C group. It was a combination of SBP30 and 7P (SB/EVA+C = 40wt%/60wt%) that showed a high bond strength and a good cell proliferation. Also, as a result of animal experiment, 7P had weaker inflammation than an SB and mineralized tissue formation was good. It was suggested that it was obtained high adhesive property and biocompatibility by adding EVA+C in an SB at the appropriate ratio in conclusion.

    DOI： 10.11223/jard.7.56

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  • A study on adhesion to the enamel treated with several bleaching agents

    KISHIMOTO Mami, SHINNO Yasuo, ANABUKI Yuka, NAKATA Takashi, YAMADA Atsuko, ABO Tomoko, NISHITANI Yoshihiro, YOSHIYAMA Masahiro

    51   120 - 120   2008.5

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  • Bond strength of selected adhesive systems to the enamel after office bleaching

    ANABUKI Yuka, SHINNO Yasuo, KISHIMOTO Mami, NAKATA Takashi, ABO Tomoko, TANAKA Kumiko, NISHITANI Yoshihiro, YOSHIYAMA Masahiro

    51   121 - 121   2008.5

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  • 臼歯垂直修復用コンポジットレジンの物性に関する検討.

    神農泰生, 岸本麻実, 穴吹優佳, 神谷絵里子, 大前正範, 西谷佳浩, 吉山昌宏

    日本歯科保存学雑誌   51 ( 6 )   622 - 628   2008

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  • P09. New treatment of bone regeneration using combined recombinant human BMP-2 and Alginic acid gel(Poster Presentation,The 5^<th> Annual Meeting of Japanese Association of Regeneration Dentistry)

    Yamaji Kozo, Nishitani Yoshihiro, Izawa Shunji, Doi Junichi, Shinno Yasuo, Omae Masanori, Abo Youko, Yamauchi Junichi, Yoshiyama Masahiro

    Journal of the Japanese Association of Regenerative Dentistry   5 ( 1 )   57 - 57   2007.12

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    Language：Japanese   Publisher：Japanese Association of Regenerative Dentistry  

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  • Influence of tissue formation following direct pulp capping using rhBMP-2 combined with alginate gel

    YAMAJI Kozo, NISHITANI Yoshihiro, IZAWA Shunji, DOI Junichi, SHINNO Yasuo, OMAE Masanori, TAKAHASHI Kei, TANAKA Kumiko, YOSHIMITSU Keiko, YAMADA Atsuko, YOSHIYAMA Masahiro

    50   29 - 29   2007.5

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  • The Physical Properties of Resin Composites in Remineralizing Solution

    KAMIYA Eriko, SHINNO Yasuo, YOSHIMITSU Keiko, NISHITANI Yoshihiro, YOSHIYAMA Masahiro

    50   70 - 70   2007.5

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  • The studies of bleaching and staining on color change of tooth

    HOSHIKA Tomohiro, OMAE Masanori, SHINO Yasuo, KAMIYA Eriko, TAKAHASHI Kei, NISHITANI Yoshihiro, YOSHIYAMA Masahiro

    50   132 - 132   2007.5

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  • P01.生体吸収性創傷被覆材Kurabio gelに対する象牙質・歯髄複合体の反応(一般演題(ポスター展示),第4回日本再生歯科医学会学術大会および総会 硬組織再生の新たな展開)

    田代 陽子, 糸田 俊之, 高木 了, 山路 公造, 伊澤 俊次, 神農 泰生, 吉山 昌宏

    日本再生歯科医学会誌   4 ( 1 )   71 - 71   2006.12

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    Language：Japanese   Publisher：日本再生歯科医学会  

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  • The Physical Properties of Resin Composites for Posterior Direct Restoration

    SHINNO Yasuo, ITOTA Toshiyuki, TASHIRO Yoko, YOSHIMITSU Keiko, YOSHIYAMA Masahiro

    49   102 - 102   2006.10

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  • Effect of delayed application of the dropped all-in-one adhesives on dentin and enamel bond strengths

    YAMADA Atsuko, TAKABATAKE Yasumitsu, YOSHIMITSU Keiko, TANAKA Kumiko, NOMOTO Masamori, TASHIRO Yoko, OMAE Masanori, DOI Junichi, SHINNO Yasuo, ITOTA Toshiyuki, YOSHIYAMA Masahiro

    49   72 - 72   2006.10

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  • Dentin Regeneration by Direct Pulp Capping Using a Bioabsorbable Material

    ITOTA Toshiyuki, TASHIRO Yoko, TAKAGI Ryo, YAMAJI Kozo, SHINNO Yasuo, IZAWA Shunji, OMAE Masanori, YOSHIYAMA Masahiro

    Journal of oral tissue engineering   4 ( 1 )   17 - 24   2006.9

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    Language：English   Publisher：Japanese Association of Regenerative Dentistry  

    The aim of this study was to investigate the effect of bioabsorbable material on the direct pulp capping to know whether this material has a function in dentin regeneration by bioabsorption. Class V cavities with the exposed pulp area were prepared on the buccal surface of first molars in young beagle dogs. All cavities were conditioned with a self-etching primer (Clearfil SE Primer). In the cavities of right side (experimental group), the exposed pulp was covered with a bioabsorbable sheet (Kurabio AG), and then the cavities were coated with an adhesive agent (Clearfil SE Bond) and resorted with a resin composite. The left side cavities (control group) were applied the adhesive agent without the bioabsorbable sheet and restored with a resin composite. On three and six months after surgery, the teeth were extracted, immersion-fixed and decalcified. Afterward, the teeth were frozen-sectioned, stained with hematoxylin and eosin and observed using a light microscopy. In the experimental group, a large amount of the tertiary dentin was formed into the prepared cavity. On the other hand, the tertiary dentin was almost not formed into the cavity in the control group. The significantly tertiary dentin formation was recognized into the prepared cavity when the exposed pulp area had been covered by a bioabsorbable material. This result suggested that the space making by a bioabsorbable material could produce the derivation of pulp tissue and then dentin regeneration into the prepared cavity.

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  • Bonding durability of a new adhesive system containing carboxylic and phosphoric acid monomers

    OMAE Masanori, TANAKA Kumiko, YAMADA Atsuko, TAKAHASHI Kei, ITOTA Toshiyuki, YOSHIYAMA Masahiro

    49   20 - 20   2006.4

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  • Bone Formation Induced by Recombinant Human BMP-2 Combined with Bioabsorbable Material at Subperiosteal Sites

    YAMAJI Kozo, NISHITANI Yoshihiro, IZAWA Shunji, SHINNO Yasuo, OMAE Masanori, YOSHIYAMA Masahiro

    Journal of Oral Tissue Engineering   4 ( 2 )   101 - 105   2006

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    Language：English   Publisher：Japanese Association of Regenerative Dentistry  

    The purpose of this study was to evaluate the effect of bone formation induced by recombinant human BMP-2 (rhBMP-2) combined with bioabsorbable material Kurabio&reg;AG (AG) at palatal subperiosteal sites in Wistar rats. AG was freeze-dried alginated gel dressing.<BR>Experimental sites were divided into three groups according to the implans : BMP group (rhBMP-2 combined with AG), AG group (AG alone) and Control group.<BR>In every group, infected region or atypical cell proliferation was not observed, and new bone formation was observed at 6 weeks after implantation. Thickness of new bone (TNB) of BMP group was significantly higher than that of AG and Control groups. There was no significant difference in TNB between AG and Control groups.<BR>These results suggest that rhBMP-2 combined with AG have the ability to promote bone formation, although AG alone do not have any effect on bone formation.

    DOI： 10.11223/jarde.4.101

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  • Dentin/pulp complex regeneration by direct pulp capping using a bioabsorbable material

    TASHIRO Yoko, ITOTA Toshiyuki, TAKAGI Ryo, YAMAJI Kozo, SHINNO Yasuo, YOSHIYAMA Masahiro

    49   210 - 210   2006

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  • 3.生体吸収性創傷被覆材を用いた象牙質・歯髄複合体の再生(一般口演,第3回日本再生歯科医学会学術大会および総会)

    糸田 俊之, 田代 陽子, 高木 了, 山路 公造, 神農 泰生, 吉山 昌宏

    日本再生歯科医学会誌   3 ( 1 )   65 - 65   2005.12

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  • Fine Deletional Mapping of Chromosome 4q22-35 Region in Oral Cancer(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)

    Shinno Yasuo, Gunduz Mehmet, Gunduz Esra, Jia Li-qun, Shimizu Kenji, Yoshiyama Masahiro, Imura Masayuki, Nagai Noriyuki

    Journal of hard tissue biology   14 ( 2 )   326 - 327   2005.10

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    Language：English   Publisher：The Society of Hard Tissue Biology  

    We analyzed loss of heterozygosity in detail of the long arm of chromosome 4 in 40 oral cancer by using 16 microsatellite markers based on the recent data from human genome sequence and defined the deletional mapping of the region with putative tumor suppressor genes. Our data revealed two distinct commonly deleted regions around the markers D4S2623 and D4S1644 with an allelic deletion of 44% and 39%, respectively. Additional mapping and use of the markers near one of these hot spots narrowed down the minimally deleted region about 1.5Mbp around the marker, D4S2623. Caspase 6 is just localized 280kb distant from the marker, D4S2623. Fine mapping of this region with possible tumor suppressor gene suggest caspase 6 as a putative tumor suppressor gene. Further molecular analysis of caspase 6 should be performed to clarify its role in oral carcinogenesis.

    DOI： 10.2485/jhtb.14.326

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    Other Link： http://search.jamas.or.jp/link/ui/2007049583

  • Identification of Caspase-6 as A Candidate Tumor Suppressor Gene at 4q25 in Oral Cancer(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)

    Shinno Yasuo, Gunduz Mehmet, Gunduz Esra, Shimizu Kenji, Yoshiyama Masahiro, Yasuoka Akira, Nagai Noriyuki

    Journal of hard tissue biology   14 ( 2 )   328 - 329   2005.10

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    Language：English   Publisher：The Society of Hard Tissue Biology  

    We recently reported the frequent deletion of chromosome 4q25 region in oral squamous cell carcinoma and discussed the Caspase-6 as a possible tumor suppressor gene in this region due to its near location to this hot spot. We this time examined the role of Caspase-6 in oral cancers. mRNA expression level, protein localization and gene mutation of Caspase-6 were analyzed. Reverse-transcription-PCR analysis demonstrated decreased expression in 40% and equal expression in 30% of Caspase-6 mRNA of primary tumors as compared with that matched normal samples. cDNA sequencing analysis of Caspase-6 did not reveal any somatic mutation. Caspase-6 protein localization was in similar proportion with its mRNA expression. Failure of Caspase-6 response in tumor samples as compared to normal samples could suggest Caspase-6 as a candidate tumor suppressor gene in a subset of oral cancer.

    DOI： 10.2485/jhtb.14.328

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    Other Link： http://search.jamas.or.jp/link/ui/2007049584

  • Fine deletional mapping of chromosome 4q22-35 region in oral cancer

    Y Shinno, E Gunduz, M Gunduz, H Nagatsuka, H Tsujigiwa, B Cengiz, YJ Lee, R Tamamura, M Ouchida, K Fukushima, K Shimizu, N Nagai

    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE   16 ( 1 )   93 - 98   2005.7

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：PROFESSOR D A SPANDIDOS  

    We analyzed the loss of heterozygosity of the long arm of chromosome 4 in 40 oral cancers, using 16 microsatellite markers based on data from the human genome sequence, and defined the deletional mapping of the region with putative tumor suppressor genes. Our data revealed two distinct commonly deleted regions around the markers, D4S2623 and D4S1644, with an allelic deletion of 44 and 39%, respectively. Additional mapping and use of the markers near one of these hot spots narrowed down the minimally deleted region about 1.5 Mbp around the marker, D4S2623. Caspase 6 is localized 280 kb from the marker, D4S2623. Fine mapping of this region with possible tumor suppressor gene suggests caspasc 6 as a putative tumor suppressor gene. Further molecular analysis of caspase 6 should be performed to clarify its role in oral carcinogenesis.

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  • 口腔扁平上皮癌におけるCaspase-6の発現

    神農 泰生, 長塚 仁, Gunduz Mehmet, Rodriguez Andrea, Han Phuu, 片瀬 直樹, 岡内 美佳, 永井 教之

    日本病理学会会誌   94 ( 1 )   205 - 205   2005.3

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    Language：Japanese   Publisher：(一社)日本病理学会  

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  • Distribution of calbindin D-28k in odontoblasts after cavity preparation in human teeth.

    Tashiro Y, Itota T, Takagi R, Shinno Y, Yoshiyama M

    Journal of Oral Tissue Engineering   2005

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  • Multiple osteolytic lesions of the jaws

    Han P P, Nagatsuka H, Tsujigiwa H, Gunduz M, Shinno Y, Rodriguez A P, Riveria R S, Nagai N

    Oral Medicine & Pathology   2005

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  • Basaloid squamous cell carcinoma of the tongue in a Japanese male patient: A case report

    Yasuo Shinno, Hitoshi Nagatsuka, Chong-Huat Siar, Hidetsugu Tsujigiwa, Ryo Tamamura, Mehmet Gunduz, You-Jin Lee, Akira Sasaki, Noriyuki Nagai

    Oral Oncology Extra   41 ( 4 )   65 - 69   2005

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    Basaloid squamous cell carcinoma (BSCC) is a virulent variant of squamous cell carcinoma. We present a case of BSCC affecting the tongue of a 57-year old Japanese male. Microscopically, BSCC was diagnosed on the basis of presence of basaloid carcinomatous component in intimate contact with smaller areas of conventional squamous cell carcinoma. Immunohistochemistry demonstrated positive staining of tumor epithelium for pan-keratin marker MNF116, CK8, CK17, CK19 and CEA, weak immunoreactivity for CK14, EMA and S-100 protein and negative staining for CK1 and alpha-smooth muscle actin. The principal differential diagnoses considered were adenoid cystic carcinoma, adenosquamous carcinoma and polymorphous low-grade adenocarcinoma. © 2005 Elsevier Ltd. All rights reserved.

    DOI： 10.1016/j.ooe.2004.12.002

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  • Epigenetic and Genetic Modifications of BRG1Gene Promotes Oral Cancer Development

    Esra Gunduz, Mehmet Gunduz

    Journal of oral biosciences   46 ( 5 )   421 - 421   2004.9

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    Language：English   Publisher：Japanese Association for Oral Biology  

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  • Loss of Heterozygosity Analysis of Chromosomal 2q22-37 Region in Oral Cancers(Asian Science Seminar/III-2, The 3^<rd> Asian Science Seminar)

    Cengiz Beyhan, Gunduz Mehmet, Nagatsuka Hitoshi, Gunduz Esra, Tsujigiwa Hidetsugu, Shinno Yasuo, Tamamura Ryo, Nagai Noriyuki

    Journal of hard tissue biology   13 ( 2 )   99 - 99   2004.9

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    Language：English   Publisher：The Society of Hard Tissue Biology  

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  • 7.エナメル上皮腫におけるAmelogenin遺伝子(AMELX,AMELY)発現の解析(第12回硬組織生物学会学術大会)

    プー ハン, 辻極 秀次, 長塚 仁, 大井田 新一郎, エスラ グンデゥズ, 玉村 亮, 神農 泰生, アンドレア ロドリゲス, 永井 敏之

    Journal of hard tissue biology   12 ( 3 )   93 - 93   2004.3

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  • Research for Identification of Tumor Suppressor Genes in Oral Cancer: Part 2

    Shinnou Yasuo, Gunduz Mehmet, Gunduz Esra, Nagai Noriyuki

    Journal of hard tissue biology   12 ( 3 )   82 - 87   2004

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    Language：Japanese   Publisher：The Society of Hard Tissue Biology  

    In our past study, we confirmed the highest Loss of heterozygosity frequency in 4q25 (D4S2623), and we observed gene Caspase-6 in the proximity to D4S2623, which has a relevant function during apoptosis and therefore can also work like TSG. So we examined Caspase-6 mRNA expression level. Reverse-transcription-PCR analysis demonstrated decreased expression in 40% and equal expression in 30% of Caspase-6 mRNA of primary tumors as compared with the matched normal samples. We also examined Caspase-6 cDNA sequencing for mutations. But no mutation was detected. These findings suggested the possibility of Caspase-6 gene to function as a tumor suppressor gene in a subset of oral SCC.

    DOI： 10.2485/jhtb.12.82

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    Other Link： http://search.jamas.or.jp/link/ui/2004215644

  • Differential Expression of Collagen IV alpha1 to alpha6 Chains in Basement Membranes of Malignant Odontogenic Tumors

    Fujii Hidetaka, Nagatsuka Hitoshi, Lee You Jin, Shinnou Taisei, Tamamura Ryo, Xiao Jing, Naitou Ichiro, Sado Giichi, Nakagawa Toshihiro, Nagai Noriyuki

    Journal of hard tissue biology   13 ( 3 )   111 - 115   2004

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    Language：Japanese   Publisher：The Society of Hard Tissue Biology  

    Type IV collagen, the major component of basement membrane (BM), demonstrates a stage- and position-specific distribution of its isoforms during tooth development. To determine its localization in BM of malignant odontogenic neoplasms, immunohistochemistry using six anti-alpha(IV) chain-specific monoclonal antibodies was performed. Results disclosed that BM demonstrated an irregular alpha(IV) chain profile in tooth germ as compared to benign odontogenic neoplasms. No alpha3(IV) chains were detected. Expression of alpha1(IV)/alpha2(IV) and alpha4(IV), alpha5(IV)/alpha6(IV) chains was ameloblastic fibro-odontosarcoma, but not the inductive hard tissues. Ameloblastic carcinoma showed specific alpha1 (IV)/alpha2(IV) chain loss, while primary intraosseous carcinoma demonstrated a discontinuous alpha1 (IV)/alpha2(IV) and alpha5(IV)/alpha6(IV) staining pattern. The present results suggest that modification and remodeling of BM collagen IV alpha chains occur during malignant odontogenic neoplasms' progression.

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  • Research for Identification of Tumor Suppressor Genes in Oral Cancer: Part 1

    Shinnou Yasuo, Gunduz Mehmet, Gunduz Esra, Nagai Noriyuki

    Journal of hard tissue biology   12 ( 3 )   75 - 81   2004

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    Language：Japanese   Publisher：The Society of Hard Tissue Biology  

    Tumor suppressor gene (TSG) has a very important role in cancer formation and squamous cell carcinoma (SCC) is the most common malignant tumor in oral region. So the aim of our study is a finding a new TSG in oral sec. Loss of Heterozygosity (LOH) is an effective means to discover TSG. In past studies, LOH has been frequently detected at chromosome 4q22-35 region in human oral SCC. This suggests the existence of tumor suppressor genes. We analysed LOH at 4q22-35 region in 40 oral SCC casrs by using 17 microsatellite markers and found allelic deletions in 85% (34/40) of the significant cases. We detected two high LOH regions, one is around D4S2623 and the other is around D4S1644. D4S2623 showed the higher LOH frequency being 44%. When we redefined the map of 4q22-35 region according to the contiguous sequences, we observed gene Caspase-6 in the proximity of D4S2623, which has a relevant function during apoptosis and therefore can also work like TSG.

    DOI： 10.2485/jhtb.12.75

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    Other Link： https://jlc.jst.go.jp/DN/JALC/00376386845?from=CiNii

  • Immunohistochemical study of BMP family in odontogenic tumors(2nd ASIAN SCIENCE SEMINAR IN OKAYAMA 2003)

    Tamamura Ryo, Nagatsuka Hitoshi, Tsujigiwa Hidetsugu, Shinno Yasuo, Inoue Masahisa, Siar Chong Huat, Nagai Noriyuki

    Journal of hard tissue biology   12 ( 2 )   71 - 71   2003.12

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    Language：English   Publisher：The Society of Hard Tissue Biology  

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  • 18.A case of rt.tongue tumor

    Shinnou Y, Nagatsuka H, Tsujigiwa H, Gunduz M, Ryou T, Nagai N

    Oral medicine & pathology   6 ( 2 )   113 - 113   2001.12

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    Language：English   Publisher：Japanese Society for Oral Pathology  

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  • Tumor-specific mutation of ING3, a novel candidate tumor suppressor gene at 7q3l, detected in head and neck squamous cell carcinomas

    Japanese journal of oral biology   43 ( 5 )   549 - 549   2001.8

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    Language：English   Publisher：Japanese Association for Oral Biology  

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  • Pheomelanin and eumelanin of malignant melanomas and melanosis in oral mucosa Reviewed

    You-Jin LEE, Noriyuki NAGAOKA, Toshiro SAKAE, Tohru TAKAGI, Hitoshi NAGATSUKA, Yasuo SHINNOU, Kazuteru HIBI, Noriyuki NAGAI, Department of oral Pathology Okayama University Dental School, Department of oral Pathology Okayama University Dental School, Department of Oral Anatomy Nihon University school of Dentistly at Matsudo, Department of oral Pathology Okayama University Dental School, Department of oral Pathology Okayama University Dental School, Department of oral Pathology Okayama University Dental School, Department of oral Pathology Okayama University Dental School

    J Jard Tissue Biol   10 ( 2 )   89-95 - 95   2001

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    Language：English   Publishing type：Research paper (scientific journal)  

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    Other Link： https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=357319

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Books

  • チェアーザイド歯科英会話.11．根管治療後、痛みが出る可能性についての会話.

    吉備人出版  2010  （ ISBN:9784860692575 ）

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  • チェアーザイド歯科英会話.10．適用可能な充填物の種類を患者に説明する会話.

    吉備人出版  2010  （ ISBN:9784860692575 ）

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  • チェアーザイド歯科英会話.９．カリエスの除去に際し、麻酔の必要性と抜髄となる可能性を説明する会話.

    吉備人出版  2010  （ ISBN:9784860692575 ）

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MISC

  • エナメル質形成不全症に対する非侵襲的治療.

    神農泰生, 吉山昌宏

    The Quintessence   33 ( 11 )   171 - 174   2014

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  • 岡山大学病院 審美歯科外来.

    伊澤俊次, 神農泰生, 山路公造, 西谷佳浩, 吉山昌宏

    審美歯科   23 ( 2 )   5 - 15   2011

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  • ワンボトルワンステップ接着剤の採取後の放置時間が歯質接着性に及ぼす影響.

    山田敦子, 高畑安光, 吉光景子, 田中久美子, 野本正盛, 田代陽子, 大前正範, 山路公造, 神農泰生, 土居潤一, 西谷佳浩, 糸田俊之, 吉山昌宏

    日本歯科保存学雑誌   50 ( 2 )   126 - 132   2007

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  • ホワイトニング前後における歯質への着色量の変化に関する研究.

    大前正範, 星加知宏, 末松亮, 西村綾乃, 美甘真, 穴吹優佳, 神谷絵里子, 岸本麻実, 林真千子, 神農泰生, 吉山昌宏

    日本歯科保存学雑誌   50 ( 6 )   675 - 680   2007

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  • ワンボトルワンステップ接着剤の採取後の放置時間が歯質接着性に及ぼす影響.

    山田敦子, 高畑安光, 吉光景子, 田中久美子, 野本正盛, 田代陽子, 大前正範, 山路公造, 神農泰生, 土居潤一, 西谷佳浩, 糸田俊之, 吉山昌宏

    日本歯科保存学雑誌   50 ( 2 )   126 - 132   2007

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  • ホワイトニング前後における歯質への着色量の変化に関する研究.

    大前正範, 星加知宏, 末松亮, 西村綾乃, 美甘真, 穴吹優佳, 神谷絵里子, 岸本麻実, 林真千子, 神農泰生, 吉山昌宏

    日本歯科保存学雑誌   50 ( 6 )   675 - 680   2007

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  • Pheomelanin and Eumelanin of Malignant Melanomas and Melanosis in Oral Mucosa

    You-Jin LEE, Noriyuki NAGAOKA, Toshiro SAKAE, Tohru TAKAGI, Hitoshi NAGATSUKA, Yasuo SHINNOU, Kazuteru HIBI, Noriyuki NAGAI, Department of oral Pathology Okayama University Dental School, Department of oral Pathology Okayama University Dental School, Department of Oral Anatomy Nihon University school of Dentistly at Matsudo, Department of oral Pathology Okayama University Dental School, Department of oral Pathology Okayama University Dental School, Department of oral Pathology Okayama University Dental School, Department of oral Pathology Okayama University Dental School

    Journal of hard tissue biology = Journal of hard tissue biology   10 ( 2 )   89 - 95   2000

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Presentations

  • 漂白後のエナメル質接着に対する還元剤の効果

    日本歯科審美学会学術大会  2011 

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  • Dentin-regeneration by the differentiated bone marrow mesenchymal stem cells

    86th International Association for Dental Research  2008 

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  • オフィスホワイトニング後のエナメル質に対する各種接着システムの接着強さ

    第128回日本歯科保存学会  2008 

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  • コラーゲン固定化エチレン-ビニルアルコール共重合体（EVA+C）添加試作石灰化誘導促進性接着材の接着強さと生体親和性に関する基礎的研究

    第129回日本歯科保存学会  2008 

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  • 各種漂白剤処理後のエナメル質に対する接着性の検討

    第128回日本歯科保存学会  2008 

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  • 再石灰化水溶液中におけるコンポジットレジンの物性に関する研究

    第126回日本歯科保存学会  2007 

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  • 直接覆髄にrhBMP-2配合アルギン酸ゲルを用いた場合の組織反応

    第126回日本歯科保存学会  2007 

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  • グルタルアルデヒド法を用いたＥｒ：ＹＡＧレーザー照射象牙質のコンポジットレジ ン接着性改善に関する研究 ポスター発表

    第10回Er:YAGレーザー臨床研究会  2007 

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  • 着色歯に対するホワイトニング効果および後戻りに関する研究

    第126回日本歯科保存学会  2007 

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  • リコンビナントヒトBMP-2配合アルギン酸ゲルを用いた骨再生療法の開発

    第5回日本再生歯科医学会  2007 

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  • Effects of remineralization-accelerating agent in odontoblast-like cell (MDPC-23)

    84th General session & exhibition of the IADR  2006 

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  • 新規カルボン酸系およびホスホン酸系接着性モノマーを配合した接着システムの接着耐久性

    第124回日本歯科保存学会  2006 

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  • スキャホールドがrhBMP-2による骨形成に及ぼす影響

    第27回岡山歯学会  2006 

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  • 生体吸収性創傷被覆材による象牙質･歯髄複合体の再生

    第125回日本歯科保存学会  2006 

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  • 生体吸収性創傷被覆材Kurabio gelに対する象牙質･歯髄複合体の反応

    第4回日本再生歯科医学会  2006 

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  • Odontoblast differentiation-dependent gene expression of bone marrow mesenchymal stem cells

    84th International Association for Dental Research  2006 

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  • ワンボトルワンステップ接着システムの採取後の放置時間が歯質接着性に及ぼす影響

    第125回日本歯科保存学会  2006 

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  • 臼歯直接修復用コンポジットレジンの物性に関する検討

    第125回日本歯科保存学会秋季大会  2006 

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  • Fine Deletional Mapping of Chromosome 4q22-35 Region in Oral Cancer

    3rd Asia Science Seminor  2005 

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  • 口腔扁平上皮癌におけるCaspase-6の発現

    第94回日本病理学会学術大会  2005 

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  • 口腔扁平上皮癌における癌抑制遺伝子候補としてのCaspase-6の検討

    岡山歯学会25周年記念シンポジウム  2005 

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  • Identification of Caspase-6 as A Candidate Tumor Suppressor Gene at 4q25 in Oral Cancer

    3rd Asia Science Seminor  2005 

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  • 生体吸収性創傷被覆材を用いた象牙質･歯髄複合体の再生

    第3回日本再生歯科医学会  2005 

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  • 下顎腫瘍

    第86回病理学会中四国支部学術集会  2005 

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  • Multiple osteolytic lesions of the jaws.

    第15回日本口腔病理学会総会  2004 

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  • 口腔扁平上皮癌における癌抑制遺伝子候補としてのCaspase-6の検討

    第46回歯科基礎医学会学術大会  2004 

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Research Projects

  • Pulp capping method with induction of dentin regeneration by remineralization materials

    Grant number：19791398  2007 - 2008

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    SHINNO Yasuo

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    Grant amount：\2970000 （ Direct expense: \2700000 、 Indirect expense：\270000 ）

    歯質再石灰化促進材として、GC社試作の RE-06とサンメディカル社試作のEVA+C(エチレンビニルアルコール共重合体+コラーゲン)添加型スーパーボンドを用いた。
    MDPC-23を用いての細胞毒性実験の結果、RE-06は多少の細胞為害性が見られるケースが認められるが、おおむね良好な結果であった。EVA+C添加型スーパーボンドでは、従来の材料とほぼ同等にほとんど細胞為害性が認められなかった。また、細胞分化に関して、両材料ともに一定の分化傾向があることが確認できた。
    また、覆髄の際に患部を口腔内環境と隔離するための充填材料について、性質を検討する必要が生じたため、各材料の物性を検討し、覆髄に適した材料を見いだした。

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