We are studing about intractable brain disorders that cannot be treated with existing clinical drugs, using electrophysiological techniques in vivo and in vitro. Our study is basic neuroscience towards drug development, and we indentify endogeneous proteins that control brain disorders (i.e., target molecule for drug development) and also identify chemical compounds that act on the target molecules (i.e., lead compound) 

Photograph

Name

INOUE Tsuyoshi

Affiliation

Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

Title

Associate Professor

Sex

male

Laboratory address

1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan

Laboratory telephone number

+81-86-251-7955

E-mail address

E-mail address

Research areas, keyword

electrophysiology

Research Subject 【 display / non-display

  • Subject:

    Object:We are studing about intractable brain disorders that cannot be treated with existing clinical drugs, using electrophysiological techniques in vivo and in vitro. Our study is basic neuroscience towards drug development, and we indentify endogeneous proteins that control brain disorders (i.e., target molecule for drug development) and also identify chemical compounds that act on the target molecules (i.e., lead compound)

 
 

Research Achievement (Published Thesis) 【 display / non-display

  • Subject:Identification of a vesicular ATP release inhibitor for the treatment of neuropathic and inflammatory pain

    Language:English

    Kind of Publishing:Academic Journal

    Journal name:Proceedings of the National Academy of Sciences of the United States of America , vol.114 (31) (p.E6297 - E6305)

    Publish date:2017.08

    Author:Yuri Kato*,Miki Hiasa*,Reiko Ichikawa,Nao Hasuzawa,Atsushi Kadowaki,Ken Iwatsuki,Kazuhiro Shima,Yasuo Endo,Yoshiro Kitahara,Tsuyoshi Inoue*,Masatoshi Nomura,Hiroshi Omote*,Yoshinori Moriyama,Takaaki Miyaji*

    Co-writerThe multiple authorship

    DOI:10.1073/pnas.1704847114

  • Subject:Neuronal inhibition and seizure suppression by acetoacetate and its analog, 2-phenylbutyrate

    Language:English

    Kind of Publishing:Academic Journal

    Journal name:Epilepsia , vol.58 (5) (p.845 - 857)

    Publish date:2017.05

    Author:Atsushi Kadowaki,Nagisa Sada*,Narinobu Juge*,Ayaka Wakasa,Yoshinori Moriyama,Tsuyoshi Inoue*

    Co-writerThe multiple authorship

    DOI:10.1111/epi.13718

  • Subject:Synaptic Multivesicular Release in the Cerebellar Cortex

    Language:English

    Kind of Publishing:Academic Journal

    Journal name:Cerebellum , vol.15 (2) (p.201 - 207)

    Publish date:2016.04

    Author:Shin’Ichiro I. Satake ,Tsuyoshi Inoue*,Keiji Imoto

    Co-writerThe multiple authorship

    DOI:10.1007/s12311-015-0677-5

  • Subject:Targeting LDH enzymes with a stiripentol analog to treat epilepsy.

    Language:English

    Kind of Publishing:Academic Journal

    Journal name:Science , vol.347 (p.1362 - 1367)

    Publish date:2015.03

    Author:Sada N, Lee S, Katsu T, Otsuki T, Inoue T

    Co-writerThe multiple authorship

  • Subject:Metabolic control of vesicular glutamate transport and release.

    Language:English

    Kind of Publishing:Academic Journal

    Journal name:Neuron , vol.68 (1) (p.99 - 112)

    Publish date:2010.10

    Author:Juge N, Gray JA, Omote H, Miyaji T, Inoue T, Hara C, Uneyama H, Edwards RH, Nicoll RA, Moriyama Y

    Co-writerThe multiple authorship