Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVES: To examine the diagnostic usefulness and procedures of ultrasonography (US) for mass lesions in the soft tissue of the oral region. METHODS: This study involved patients with mass lesions (tumorous lesions and cysts) who had undergone US and histopathological examinations from January 2017 to December 2019. The following points were evaluated by two observers using an evaluation scale: vascularity, echo intensity level, boundary, margin shape, distribution of internal echoes, and capsule. The usefulness of each point for differential diagnosis of tumorous lesions and cysts was statistically analyzed. RESULTS: Forty-five mass lesions in the soft tissue of the oral region (33 tumorous lesions and 12 cysts) were analyzed. There were significant differences in four evaluation points between the tumorous lesions and cysts: vascularity, echo intensity level, boundary, and margin shape. Cysts were almost completely excluded diagnostically, especially when vascularity was observed. There were also significant differences in two evaluation points between nonvascular tumorous lesions and cysts: echo intensity level and boundary. CONCLUSIONS: In US examination for mass lesions in the oral region, it was possible to diagnose tumorous lesions and exclude cysts when vascularity was observed. When vascularity was not observed, however, tumorous lesions and cysts could be identified using two evaluation points: echo intensity level and boundary.

DOI： 10.1007/s11282-022-00605-2

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Language：English   Publishing type：Research paper (scientific journal)  

Purpose: To focus on the effects of the presence of mesiodens on adjacent teeth and to investigate the timing of its safe removal. Materials and Methods: Cone-beam computed tomography examinations, obtained at Okayama University Hospital over a three-year period, were inspected. Data were recorded including the number of mesiodens; associated abnormalities; and the relationship with neighboring structures. Depending on multiple factors, the risk of developing complications due to early extraction of a mesiodens was divided into three categories: high, medium, and low risk. Results: A total of 5,958 cone-beam computed tomography exams were obtained, 460 patients aged 3-85 years were diagnosed with a total of 568 mesiodens, 382 (67.3%) of which were discovered in young patients (age <10 years), and 333 (87.2%) of these were associated with abnormalities. Regarding the risk categories, 11 (1.9%) were considered to be in the high-risk, five (0.9%) in the medium-risk and 552 (97.2%) in the low-risk categories. Moreover, eight out of 11 high-risk mesiodens were extracted and no post-operative complications have been seen. Conclusion: As the results showed that no postoperative complications were seen in all the extracted cases of high-risk mesiodens, this indicates the possibility of safe extraction at an early age which could reduce related future complications.

DOI： 10.5624/isd.20210218

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPANDIDOS PUBL LTD  

Immune checkpoint inhibitors (ICIs) targeting programmed death ligand-1 (PD-L1) are highly promising therapies for oral squamous cell carcinoma (OSCC). The assessment of PD-L1 expression may help predicting the therapeutic effect of ICIs and, thus, benefit patient selection. Contrast index (CI) parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) have been proven as efficient to assess microvessel density (MVD) in OSCC. The present study aimed to determine the correlation between DCE-MRI parameters and MVD and between DCE-MRI parameters and PD-L1 expression to determine whether DCE-MRI could be used non-invasively to evaluate PD-L1 expression in patients with OSCC. A total of 21 patients with primary OSCC who had undergone a 3T MRI scan, including DCE-MRI, were included in the present study, and CI curve-derived parameters were examined. The MVD and PD-L1 expression in the surgically resected specimens were analyzed using immunohistochemistry (IHC) staining for CD31 and IHC staining for PD-L1, respectively. The results demonstrated that the expression levels of these markers were correlated with DCE-MRI parameters. PD-L1 expression levels were found to be significantly correlated with the maximum CI (CI-max; P=0.007), peak CI (CI-peak; P=0.007), maximum CI gain (CI-gain; P=0.006) and MVD (P=0.001) values. The mean CI-max, CI-peak, CI-gain and MVD values were significantly higher in tumors with high PD-L1 expression (P<0.05). MVD levels were also significantly correlated with the time of CI-max (T-max; P=0.003) and CI-gain (P=0.037). The mean CI-gain was significantly increased, and the mean T-max was significantly shorter in high MVD tumors (P<0.05 and P<0.01, respectively). In summary, the findings from the present study confirmed the correlation between CI parameters, derived from DCE-MRI, and MVD, and suggested that these parameters may be correlated with PD-L1 expression in OSCC tumor cells.

DOI： 10.3892/ol.2021.13039

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVES: The purpose of this study was to evaluate the usefulness of Hounsfield unit (HU) assessment with multislice-CT in the differentiation of radicular cysts (RCs), dentigerous cysts (DCs) and odontogenic keratocysts (OKCs). METHODS: In total, 307 odontogenic cysts (RCs, DCs and OKCs) were included in this study. Cysts with lesion diameter <10 mm, cysts with artefacts affecting measurement of HU values, cysts involving infection and recurrent cysts were regarded as exclusion criteria. Images were acquired in three different types of CT scanners: Aquilion ONE, Discovery CT750 HD and SOMATOM Definition Flash. Differences in HU values among scanners and among types of odontogenic cysts were assessed using one-way analysis of variance; multiple comparisons were performed post hoc, using the Tukey-Kramer honestly significant difference test. RESULTS: In total, 164 cysts were analysed in this study (64 RCs, 57 DCs and 43 OKCs). Regardless of the type of lesion, the Aquilion ONE scanner demonstrated a significant difference in HU value, compared with the Discovery CT750 HD scanner. Regardless of CT scanner model, HU values significantly differed between DCs and OKCs (p < 0.0001), as well as between OKCs and RCs (p < 0.0001). CONCLUSIONS: HU values were found to vary among CT scanners and should always be associated with other lesion imaging features while interpreting and elaboration diagnostic hypothesis. Notably, the results suggested that OKCs might be able to be differentiated from DCs and RCs by using HU values.

DOI： 10.1259/dmfr.20200188

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Korean Academy of Oral and Maxillofacial Radiology  

DOI： 10.5624/isd.20200253

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Other Link： https://isdent.org/DOIx.php?id=10.5624/isd.20200253

Language：Japanese   Publisher：岡山歯学会  

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Language：Japanese   Publisher：岡山歯学会  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

OBJECTIVES: This systematic literature review addresses the use of diffusion-weighted magnetic resonance imaging (DWI) and apparent diffusion coefficient (ADC) for the evaluation of benign maxillomandibular odontogenic lesions. STUDY DESIGN: Databases were searched, and original research studies or case report manuscripts up to April 2019 were included, using the keyword "diffusion," combined with the keywords "maxillofacial pathology," "oral pathology," "odontogenic tumors," "dental tissue neoplasms," "odontogenic cysts," and the histologic denomination of benign odontogenic lesions, according to the World Health Organization classification. Only English language articles and studies pertaining to DWI were selected. RESULTS: Fifteen investigations (11 original articles and 4 case reports) of distinct benign odontogenic lesions were included. Most studies did not include exclusively odontogenic lesions in their samples. CONCLUSIONS: It is too early to reach a conclusion that DWI and ADC can provide useful information in the differentiation of the histologic type of some benign odontogenic lesions on the basis of available data in the literature.

DOI： 10.1016/j.oooo.2019.11.009

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPANDIDOS PUBL LTD  

The numbers of abnormal findings incidentally detected in adjacent regions are increasing with advances in imaging modalities. The present study aimed to examine the prevalence and characteristics of incidental findings in the thyroid gland on computed tomography (CT) images of the oral and maxillofacial region. CT scans of the oral and maxillofacial region in patients obtained between January 2012 and December 2016 were retrospectively reviewed. Images that revealed incidental findings in the thyroid gland, including nodules, were recorded, together with the sizes and characteristics of the findings. The Japan Association of Breast and Thyroid Sonology (JABTS) guidelines were used for classification. The rate of descriptions of these findings in the radiographic interpretation reports were also examined. Of the 1,135 patients examined, 326 (28.7%) had several types of incidental findings. In particular, 169 (14.9%) of the 1,135 patients had nodules >5 mm in diameter, for which further careful examination is recommended in the JABTS guideline. The description rate for nodules >5 mm in diameter in the radiographic interpretation reports was 30.8% (52/169 patients), of whom 17.3% (9/52 patients) were referred to the endocrinology department for further careful examination. Incidental findings in the thyroid gland were relatively common on CT images of the oral and maxillofacial region. Oral radiologists tend to focus specifically on the oral and maxillofacial region during diagnosis on oral and maxillofacial CT images, but should pay the same careful attention to observe adjacent regions, such as the thyroid gland.

DOI： 10.3892/ol.2020.11298

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

OBJECTIVES: The aim of this systematic literature review was to focus on the use of diffusion-weighted magnetic resonance imaging (DWI) in the evaluation of salivary gland diseases. STUDY DESIGN: Databases were searched, and original research manuscripts up to 2018 were identified by using the keywords "diffusion" combined with "salivary gland," "salivary gland neoplasm," "sialadenitis," "parotid gland," "submandibular gland," "sublingual gland," "minor salivary gland," "salivary gland fistula," "salivary gland calculi," "salivary ducts," "xerostomia," and "sialorrhea." Only English language manuscripts and studies pertaining to DWI were selected. RESULTS: In all, 66 investigations regarding various salivary gland diseases, such as neoplasms, postirradiation changes, and inflammatory and autoimmune diseases, were included. Most study objectives involved the use of the apparent diffusion coefficient (ADC) in differentiating between benign lesions and malignant neoplasms. Histologic features of evaluated samples were heterogeneous. CONCLUSIONS: DWI may improve the differential diagnosis of salivary gland diseases, particularly in distinguishing between benign and malignant neoplasms. A unique ADC cutoff value could not be established because of the heterogeneity of the methods applied for ADC assessment and the heterogeneity of the diseases. DWI and the ADC are valuable tools in the diagnosis of salivary gland disease.

DOI： 10.1016/j.oooo.2019.02.020

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s11282-018-0359-3

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：岡山歯学会  

歯学部学生の臨床前基礎実習において透明根管模型歯は、全ての学生が同一条件下で実習を行えることや、根管治療における各ステップを目視できる等の利点がある。今回、本学歯学部4年次生47名が象牙質歯髄複合体診断・治療学実習の実技試験で根管充填を行った透明根管模型歯について、視診による評価と、デジタルX線画像のモニタ上での視診による評価、およびデジタルX線画像を画像解析ソフト(ImageJ)により解析した評価を行い、各評価法の妥当性について比較検討した。その結果、画像解析ソフトで解析する方法は成績の過小評価を防ぐうえで有用であり、より客観的な評価が可能と考えられた。

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Universidade de Sao Paulo, Agencia USP de Gestao da Informacao Academica (AGUIA)  

Objective: The aim of this study was to evaluate the radiographic aspects of the major salivary glands in sialography and their grade of inflammation with patients’ individual characteristics. Methods: A total of 30 radiographic images of both parotid and submandibular glands from 25 patients, who underwent sialography examinations, were retrospectively analyzed. Chi-squared test was performed to correlate the grade of inflammation of each area of the salivary glands with the categorical variables: sex, type and side of the affected gland. Pearson correlation was performed to correlate the grade of inflammation between the main duct and the intraglandular duct and the parenchyma. Results: There was no statistically significant relationship between the grade of inflammation of any of the parts of the salivary glands and the categorical variables in the Chi-squared test (p&gt;0.05). The grade of inflammation in the main duct had a weak correlation with the degree of inflammation in the intraglandular duct (p&lt;0.05). Conclusions: Salivary glands affected by obstruction or inflammation are not significantly related to the sex of patients, not to the type or side of the affected gland. The , but sialography examination demonstrated the delicate anatomy of the ductal system and allowed an accurate visualization of sialoliths and strictures that are two of the most common causes of obstruction, showing its important role in the assessment of salivary gland status.

DOI： 10.11606/issn.2357-8041.clrd.2019.150319

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Language：English   Publishing type：Research paper (scientific journal)  

PURPOSE: The prevalence of supernumerary teeth has been reported to be between 0.1% and 3.8%. The aim of this study was to determine the prevalence, clinical significance, and associated pathologies of fourth molars based on a retrospective study and a literature review. MATERIALS AND METHODS: A 5-year retrospective prevalence study was conducted at the Department of Oral Diagnosis and Dentomaxillofacial Radiology of Okayama University Hospital, Okayama, Japan. The study involved extracting data from the digital records of patients from January 1, 2013 through December 31, 2017. The sampling frame included all patients who had panoramic radiographs, cone-beam computed tomography (CT), and multislice CT images during the period under review. RESULTS: A total of 26,721 cases were reviewed and 87 fourth molars were identified. The prevalence of fourth molars in the 5-year study at Okayama was calculated as 0.32%. The mean age of patients with a fourth molar was 30.43 years, and the male-to-female ratio was 1:0.98. The vast majority of cases were in the maxilla (92%) and had normal shapes (89.7%); furthermore, 82.8% of cases were unerupted. CONCLUSION: The prevalence of fourth molars in the study population was found to be 0.32%, and fourth molars occurred with approximately equal frequency in males and females. Fourth molars were more common in the maxilla and were predominantly unerupted and small.

DOI： 10.5624/isd.2019.49.1.27

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Medicina Oral, S.L.  

DOI： 10.4317/medoral.22592

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Language：English   Publishing type：Research paper (scientific journal)  

Objectives: To investigate the correlations among various temporomandibular joint (TMJ) findings on MRI and the relationships between MRI findings and symptoms. Methods: 425 patients (850 TMJs) with temporomandibular joint disorders (TMDs) who underwent MRI were enrolled. Oblique sagittal proton density-weighted and T2 weighted images in open- and closed-mouth positions were evaluated. MRI findings included disc configuration, disc position, condylar morphology, bone marrow pattern, and joint effusion. Symptoms included TMJ pain, TMJ noise, and limitation of mouth opening. For statistical analyses, Spearman's rank correlation coefficient and logistic regression analysis were applied. Results: Folded disc, disc displacement without reduction (DDWOR), and osteophytes had significant negative correlations with other normal MRI findings (p < 0.01). DDWOR and marrow edema were associated with TMJ pain. Conversely, osteophytes [odds ratio (OR): 0.52; 95% CI (0.30-0.90)] and combination-type condylar degeneration [OR: 0.45; 95% CI (0.24-0.83)] were associated with decreased risk of TMJ pain. Condylar flattening was positively associated with TMJ noise [OR: 5.25; 95% CI (1.44-19.07)] and negatively associated with limitation of mouth opening [OR: 0.34; 95% CI (0.11-0.99)]. High-grade joint effusion was significantly associated with TMJ pain and noise. conclusions: DDWOR and high-grade joint effusion (an indicator of inflammation in the articular cavity) were associated with TMD symptoms. This finding suggests that treatment strategy for DDWOR and decreasing inflammation might lessen clinical TMD symptoms. Condylar degeneration was not associated with indicators of inflammation or TMJ symptoms. These results suggest that patients with TMD symptoms should undergo initial MRI to allow rapid selection of appropriate therapies.

DOI： 10.1259/dmfr.20170412

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Lepidus Tecnologia  

DOI： 10.14295/bds.2018.v21i2.1557

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Language：Japanese   Publisher：(株)文光堂  

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Universidade de Sao Paulo, Agencia USP de Gestao da Informacao Academica (AGUIA)  

Chronic periapical lesion is among the most usual bone pathology observed in human teeth, and it is often first detected by plain radiographs, such as panoramic or periapical radiography. Plain radiographs are widely used in dentistry; however, they have limitations inherent to the technique itself, such as anatomic structures overlapping and lack of information on the extension of the lesion. Therefore, three-dimensional radiographic methods, such as cone beam computed tomography are valuable to accurately assess periapical lesions. Thus, this clinical report describes a case in which the bone radiographic features led to a primary diagnosis of chronic periapical lesion in superior incisors, however, it was a defect in the palatal bone. The resulting radiolucency created by the palatal bone defect overlapped the maxillary bone, mimicking a periapical lesion. Additionally, in the same case, we demonstrate a true chronic periapical lesion in another area that presented as a subtle radiolucency in periapical radiography, however, it was larger than expected when evaluated in Cone Beam Computed Tomography.

DOI： 10.11606/issn.2357-8041.clrd.2017.140721

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Society for Hard Tissue Regenerative Biology  

© 2018, Society of Hard Tissue Regenerative Biology. All rights reserved. Contrast-enhanced (CE)-MR image is useful to distinguish cystic and solid portions on multilocular lesion, however, the CE-MR examination is contraindicated in patients with kidney disease. Fluid-attenuated inversion recovery (FLAIR) image is one of methods which signal of fluid is suppressed. This study investigated qualitatively and quantitative-ly whether FLAIR images were useful for detecting and differentiating cystic and solid portions of multilocular ameloblastomas. We retrospectively reviewed 11 cases of multilocular ameloblastoma. FLAIR and short T1 inversion recovery (STIR) sequences were performed in all cases, CE-MR images in 10 cases, and T1-weighted images (T1WI) in 7 cases. FLAIR, STIR, CE-MR, and T1WI images were visually evaluated (qualitative analysis). Signal-to-noise ratio (SNR) of cystic and solid portions were measured and compared among the images of all sequences (quantitative analysis). FLAIR imaging could detect cystic portions with very low SI in all cases because cystic fluid was well suppressed on the images, and the solid portion showed intermediate SI. On some STIR images, the solid portion was masked by the markedly high SI of the cystic fluid. CE-T1WI and CE-FLAIR images showed no enhancement of the cystic portion but enhancement of the solid portion. On FLAIR image, SNR of solid was higher than cystic portion (p &lt; 0.05). Cystic and solid portions of a lesion could be detected and distinguished on FLAIR imaging. FLAIR images are thus useful for diagnosing multilocular ameloblastoma when CE-MR cannot be performed.

DOI： 10.2485/jhtb.27.275

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.3892/mco.2017.1478

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Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: We herein described a rare case of schwannoma of the hypoglossal nerve in the submandibular region with diagnostic imaging and histopathological findings. CASE REPORT: A 31-years-old woman has had a palpable firm, rubbery, freely mobile mass in the submandibular region. Of imaging, MR images showed homogeneous isointensity on T1-weighted imaging (T1-WI), heterogeneous hypointensity on T2-WI, heterogeneous hyperintensity on short T1 inversion recovery (STIR), and heterogeneous enhancement on contrast-enhanced T1-WI. A clear capsule was observed on the margin and showed hypointense on T2-WI. Dynamic MRI showed heterogeneous gradual increased enhancement. The uptake of contrast medium was regionally slow. Diagnostic imaging using CT and MRI was suspected of salivary gland tumor or neurogenic tumor. In consideration of imaging diagnosis, a pleomorphic adenoma or a schwannoma was suspected. Final diagnosis was confirmed on the basis of histopathological finding and intraoperative findings. CONCLUSION: 1. Histopathologic examination is inevitable, because MR findings are not specific.2. Schwannomas were said to have specific MRI properties, including specific signs (split-fat sign, fascicular sign, target sign). However, they are not always observed.3. This case confirmed the differential diagnosis on the basis of the intraoperative finding that the tumor was continuous with the hypoglossal nerve.

DOI： 10.2174/1874210601812010012

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Korean Academy of Oral and Maxillofacial Radiology  

Mandibular bone depression, also known as Stafne bone cavity, is defined as a bone depression filled mainly with salivary gland tissue. Parotid gland bone defects are infrequently observed. We report the case of a 52-yearold male patient who underwent radiographic examinations due to temporomandibular joint dysfunction, and a radiolucent area was detected in the mandibular ramus, with a provisional diagnosis of traumatic bone cyst or parotid mandibular bone defect. The patient was then referred for magnetic resonance imaging, which demonstrated a hyperintense area eroding the mandibular ramus, which corresponded to glandular tissue. Although the defect was a benign lesion, radiolucencies in the mandibular ramus lead to concerns among professionals, because their radiographic features can resemble various intrabony neoplastic lesions, such as giant cell tumors or benign tumors of the parotid gland.

DOI： 10.5624/isd.2017.47.4.269

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DOI： 10.1007/s11282-017-0285-9

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPRINGER  

It is known that the magnetic resonance (MR) imaging features of dentigerous cysts (DCs) are the same as those of other cysts. The cavities of DCs generally show low signal intensity (SI) on T1-weighted imaging (T1WI). However, in our experience, DCs often show high SI on T1WI, rendering them difficult to distinguish from keratocystic odontogenic tumors (KCOTs). In this study, we evaluated seven cases of DC and 23 cases of KCOT to assess whether MR imaging can provide additional information for the differential diagnosis of DC and KCOT.
Two trials were evaluated. The first trial was an analysis of the cystic cavity SI on T1WI. To compare the SI between patients, we performed T1WI with contrast (T1c). The second trial analyzed the SI uniformity (U (I )) pound on T1WI, T2-weighted imaging (T2WI), and short inversion time inversion recovery (STIR) images of the cystic cavity, because it has been reported that an MR imaging feature of KCOT is heterogeneous SI. Statistical analyses were performed using the Mann-Whitney U test and a receiver operating characteristic (ROC) curve.
The T1c values of DCs were significantly higher than those for KCOTs. The U (I ) pound values on T1WI and STIR images were significantly higher for DCs than for KCOTs. The T1c cutoff values (0.66 and 0.84) and U (I ) pound cutoff values for T1WI (82.1 %) and STIR images (79.8 %) were determined from the ROC analyses.
T1c and U (I ) pound values provide useful additional information for the differential diagnosis of DC and KCOT.

DOI： 10.1007/s11282-013-0128-2

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：BRITISH INST RADIOLOGY  

Objectives: To evaluate the diagnostic value of MRI for odontogenic tumours.
Materials and methods: 51 patients with odontogenic tumours were subjected to preoperative MRI examinations. For tumours with liquid components, i.e. ameloblastomas and keratocystic odontogenic tumours (KCOTs), the signal intensity (SI) uniformity of their cystic components (U Sigma) was calculated and then their U Sigma values were compared. For tumours with solid components that had been examined using dynamic contrast-enhanced MRI (DCE-MRI), their CImax (maximum contrast index), T-max (the time when CImax occurred), CIpeak (CImax x 0.90), T-peak (the time when CIpeak occurred) and CI300 (i.e. the CI observed at 300 s after contrast medium injection) values were determined from CI curves. We then classified the odontogenic tumours according to their DCE-MRI parameters.
Results: Significant differences between the U Sigma values of the ameloblastomas and KCOT were observed on T-1 weighted images, T-2 weighted images and short TI inversion recovery images. Depending on their DCE-MRI parameters, we classified the odontogenic tumours into the following five types: Type A, CIpeak &gt; 2.0 and T-peak &lt; 200 s; Type B, CIpeak &lt; 2.0 and T-peak &lt; 200 s; Type C, CI300 &gt; 2.0 and T-max &lt; 600 s; Type D, CI300 &gt; 2.0 and T-max &gt; 600 s; Type E, CI300 &lt; 2.0 and T-max &gt; 600 S.
Conclusion: Cystic component SI uniformity was found to be useful for differentiating between ameloblastomas and KCOT. However, the DCE-MRI parameters of odontogenic tumours, except for odontogenic fibromas and odontogenic myxomas, contributed little to their differential diagnosis.

DOI： 10.1259/dmfr.20120265

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Language：English   Publishing type：Research paper (scientific journal)  

It is well known that many tumor tissues show lower apparent diffusion coefficient (ADC) values, and that several factors are involved in the reduction of ADC values. The aim of this study was to clarify how much each factor contributes to decreases in ADC values. We investigate the roles of cell density, extracellular space, intracellular factors, apoptosis and necrosis in ADC values using bio-phantoms. The ADC values of bio-phantoms, in which Jurkat cells were encapsulated by gellan gum, were measured by a 1.5-Tesla magnetic resonance imaging device with constant diffusion time of 30 sec. Heating at 42° C was used to induce apoptosis while heating at 48°C was used to induce necrosis. Cell death after heating was evaluated by flow cytometric analysis and electron microscopy. The ADC values of bio-phantoms including non-heated cells decreased linearly with increases in cell density, and showed a steep decline when the distance between cells became less than 3/um. The analysis of ADC values of cells after destruction of cellular structures by sonication suggested that approximately two-thirds of the ADC values of cells originate from their cellular structures. The ADC values of bio-phantoms including necrotic cells increased while those including apoptotic cells decreased. This study quantitatively clarified the role of the cellular factors and the extracellular space in determining the ADC values produced by tumor cells. The intermediate diffusion time of 30 msec might be optimal to distinguish between apoptosis and necrosis.

DOI： 10.18926/AMO/52009

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：岡山歯学会  

Audience Response Systemは、講演や講義において講演者の質問やアンケートにリモコンを通して聴衆者がリアルタイムに答えることができる双方向式システム(クリッカー)である。歯科放射線学分野の講義において、歯学部4年次学生52名を対象に、学習意欲と理解力を高めると共に集中力を持続させることおよび理解度の把握を目的として、クリッカーを用いた参加型講義を実施した。講義後にアンケートを行った結果、98%が「総合的にクリッカーは講義に有効であった」と回答した。クリッカーを使用した参加型講義について、「講義への出席意欲・興味が高まった」98%、「講義内容の理解に役立った」100%、「授業に集中できた」94%と、極めて高い肯定的回答率が得られた。

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER IRELAND LTD  

Objectives: To evaluate the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI) for differentiating between benign and malignant tumors in the palate.
Materials and methods: 26 patients with submucosal palatal tumors were preoperatively examined using DCE-MRI. Their maximum contrast index (CImax), time of CImax (Tmax), and washout ratios (WR300 and WR600) were determined from contrast index curves. The submucosal palatal tumors were divided into two groups according to their Tmax values: the early enhancement group (Tmax &lt; 300 s) consisted of 9 malignant tumors and 6 benign tumors, while the late enhancement group (Tmax &gt;= 300 s) included one malignant tumor and 10 benign tumors. We compared the following DCE-MRI parameters between the benign and malignant tumors: CImax and Tmax in all cases and CImax, Tmax, and the washout ratios in the early enhancement group. In addition, we performed a regression analysis of the relationships between tumor size and DCE-MRI parameters; i. e., CImax, Tmax, and washout ratios, among the malignant salivary gland tumors and pleomorphic adenomas.
Results: In all cases and the early enhancement group, significant differences in Tmax were detected between the benign and malignant tumors (P &lt; 0.001 and P &lt; 0.05, respectively), and the optimal Tmax cutoff value for differentiating between them was found to be 165 s. None of the other parameters displayed significant differences between the benign and malignant tumors. Only the WR600 of the pleomorphic adenomas was significantly correlated with tumor size (R-2 = 0.92, P &lt; 0.001).
Conclusions: Tmax is a useful parameter for distinguishing between benign and malignant submucosal palatal tumors. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.ejrad.2012.04.009

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER IRELAND LTD  

Objective: To evaluate the diagnostic value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for minor salivary gland tumors in the oral cavity.
Materials and methods: Thirty-two patients with minor salivary gland tumors were examined preoperatively using DCE-MRI. Their maximum contrast index (CImax), time of CImax (Tmax), Tpeak; i.e., the time that corresponded to the CImax x 0.90, and washout ratios (WR300 and WR600) were determined from contrast index (CI) curves. We compared these parameters between benign and malignant tumors and among the different histopathological types of minor salivary gland tumors. Then, we categorized the patients' CI curves into four patterns (gradual increase, rapid increase with high washout ratio, rapid increase with low washout, and flat).
Results: Statistically significant differences in Tmax (P = 0.004) and Tpeak (P = 0.002) were observed between the benign and malignant tumors. Regarding each histopathological tumor type, significant differences in Tmax (P &lt; 0.001), Tpeak (P &lt; 0.001), and WR600 (P = 0.026) were observed between the pleomorphic adenomas and mucoepidermoid carcinomas. It was difficult to distinguish between benign and malignant tumors using our CI curve classification because that two-thirds of the cases were classified into the same type (gradual increase).
Conclusion: The DCE-MRI parameters of minor salivary gland tumors contributed little to their differential diagnosis compared with those for major salivary gland tumors. During the diagnosis of minor salivary gland tumors, Tmax is useful for distinguishing between benign and malignant tumors. (c) 2011 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.ejrad.2011.11.005

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Ameloblastomas and keratocystic odontogenic tumors (KCOT) are typical jawbone tumors. In addition, dentigerous cysts (DC) and radicular cysts are the most common cystic jawbone lesions, and simple bone cysts (SBC) are the most common jawbone pseudocysts. When these lesions are unilocular, it can be difficult to diagnose them by radiography. In recent years, adding magnetic resonance (MR) imaging to obtain information about soft tissue has been shown to improve the accuracy of jawbone lesion diagnosis. We also have reported MR imaging features of jawbone lesions. However, no systematic method for MR imaging diagnosis of jawbone lesions has been reported. In this review, we examine unilocular lesions such as ameloblastoma, KCOT, adenomatoid odontogenic tumour (AOT), DC, and SBC. First, we describe the MR imaging features of each lesion. Then, we describe our novel MR imaging diagnostic protocol. Using our MR imaging diagnostic protocol to diagnose 31 cases, we obtained a positivity rate of 71.0%. The use of our MR imaging diagnostic protocol for unilocular lesions, which are especially difficult to differentiate by radiography, would improve the morphological and qualitative diagnosis of soft tissue lesions. © 2012 Japanese Association for Dental Science.

DOI： 10.1016/j.jdsr.2012.01.001

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It is sometimes difficult to differentiate cysts and pseudocysts from tumors in the jawbone on the basis of conventional radiographs. Moreover, cysts and pseudocysts that arise in soft tissue can not be detected on radiographic images without the use of contrast agents. Therefore, additional information is sometimes required to diagnose these lesions. Computed tomography and magnetic resonance imaging (CT; MRI) have been demonstrated to be very useful for depicting normal structures and pathological processes in the oral and maxillofacial region. Whereas CT is best for depicting bone structures, MRI is superior to CT at evaluating soft tissue. The contents of bone lesions might also be better visualized on MRI. In this chapter, among the variety of lesions that occur in the oral and maxillofacial region, we would like to focus on those arising in the jaw or adjacent soft tissue. We present their representative CT and MRI findings and discuss the imaging characteristics that most contribute to their differential diagnosis. © 2012 by Nova Science Publishers, Inc. All rights reserved.

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE INC  

Objective. The purpose of this study was to evaluate the diagnostic value of magnetic resonance imaging (MRI), especially dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), in extranodal non-Hodgkin lymphoma (NHL) of oral and maxillofacial regions.
Study design. Thirteen cases with extranodal NHL were examined using MRI. T1-weighted images (T1WI) and T2-weighted images (T2WI) or short TI inversion recovery (STIR) images were obtained in all cases. Contrast-enhanced images and DCEM-RI were acquired in 10 and 7 cases, respectively. On DCE-MRIs, we analyzed the parameters as follows: contrast index at maximal contrast enhancement (CImax), maximum contrast index (CI) gain/CImax ratio, and washout ratios (WR300, WR600, and WR900) at 300, 600, and 900 seconds after contrast medium injection.
Results. The signal intensity of all lesions was hypointense to isointense on T1WIs and showed variable contrast enhancement patterns. On T2WIs and STIR images, the signal intensity was isointense to hyperintense in almost all cases. Analysis of DCE-MRI parameters in extranodal NHLs resulted in the identification of 4 types of CI curves according to CImax and WR: (1) CImax greater than 2.0 and WR900 greater than 40%, (2) CImax greater than 2.0 and WR900 less than 40%, (3) CImax less than 1.5 and WR900 greater than 40%, and (4) CImax less than 1.5 and WR900 greater than 40%.
Conclusions. The signal intensities on MRI were not specific to extranodal NHL and resembled those of other tumor types. When CImax was less than 1.5 or WR900 was less than 40%, these parameters contributed to diagnosis in extranodal NHLs. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012; 113: 126-133)

DOI： 10.1016/j.tripleo.2011.07.038

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：岡山歯学会  

「歯科放射線学分野」の講義試験としてe-learning(WebClassシステム)によるPCを用いた試験を試み、受験生56名に試験後アンケート調査を行ってその有用性について検討した。肯定的回答(大変そう思う・そう思う)の割合は、PC使用試験については「共用試験CBTの予行として役立つ」100%、「試験解説がすぐに受けられる」93%、「試験結果がすぐに公表される」78%で、低かったのは「試験に集中しやすい」46%、「システムの使用が難しい」49%であった。試験会場については「席による不公平がない」91%、「講義室からの移動が面倒」71%であった。視覚素材については、「あると問題が理解しやすい」96%、「問題が難しくなる」52%であった。試験内容(選択問題)については、「国家試験、CBTの予行になる」「採点結果が明確」100%、「理解度をアピールしにくい」72%、「楽だ」35%、「語彙力、理解力低下につながる」47%であった。共用試験CBT後のアンケートではPC使用試験が「予行として役立った」98%であった。

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：MOSBY-ELSEVIER  

Malignant lymphoma is the second-most common malignancy in the head and neck region. Waldeyer&apos;s ring is the most common site of extranodal Hodgkin&apos;s lymphoma (NHL) in that region, and a small percentage of primary extranodal NHL occurs in the oral cavity. The most common sites of extranodal NHL in the oral region are the palate and maxilla, and nearly half of extranodal NHL cases arise from bone. It is difficult to diagnose extranodal NHL because of the variety of its radiological features. We report a case of primary extranodal NHL of the maxilla in a 68-year-old female patient with atypical imaging findings, along with the results of analysis of dynamic magnetic resonance imaging (MRI). (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011; 112: e59-e69)

DOI： 10.1016/j.tripleo.2011.02.052

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：MOSBY-ELSEVIER  

Ameloblastic carcinoma is a rare malignant odontogenic carcinoma that has metastatic potential, and because of its rare incidence, there are few reports focusing on its radiologic imaging. If it shows aggressive appearances, it can be diagnosed as malignant tumor. But in case of negative appearance, it is difficult to distinguish ameloblastic carcinoma from ameloblastoma. We report a case of ameloblastic carcinoma of the maxilla in a 76-year-old female patient with radiologic images and pathologic features. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011; 112: e40-e47)

DOI： 10.1016/j.tripleo.2011.01.023

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Magnetic resonance imaging (MRI) is effective for diagnosing tumors and has some advantages over traditional techniques, especially in detecting soft tissue lesions. However, MRI examination has not yet come into use for the differential diagnosis of tumors or for determining whether a tumor is benign or malignant. It has been reported that dynamic contrast-enhanced MRI (DCE-MRI) is useful for the differential diagnosis of some tumors, and many investigators have attempted to use it to identify differences between benign and malignant tumors, as well as to assess the malignancy of tumors. Oral malignancies (carcinomas and sarcomas) may develop as primary lesions originating from any type of oral tissue. The most common oral cancers are squamous cell carcinomas (SCCs), followed by salivary grand malignant tumors such as adenoid cystic carcinomas (ACCs) and mucoepidermoid carcinomas (MECs). Malignant lymphoma is the second most common malignant tumor of the head and neck. In this chapter, we show the roles of MRI and DCE-MRI in the differential diagnosis of SCCs, salivary gland tumors, and malignant lymphoma. © 2011 by Nova Science Publishers, Inc. All rights reserved.

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE BV  

Typical MR images of ameloblastomas on T2-weighted image (WI) or short inversion time inversion-recovery (STIR) show multiple bright high-signal-intensity loci on a high-signal-intensity background. Unilocular cystic-type ameloblastomas show homogeneously bright high signal intensity on T2WI or STIR as a water-like signal intensity. Therefore, it is difficult to distinguish unilocular cystic-type ameloblastoma from other cystic lesions such as keratocystic odontogenic tumors, radicular cysts (residual cysts) and dentigerous cysts only on the basis of MRI signal intensity. In the present study, we evaluated whether contrast-enhanced (CE)-T1WI and dynamic CE-MRI (DCE-MRI) could provide additional information for differential diagnosis in unilocular cystic-type ameloblastoma. Images from 12 cases of suspected unilocular cystic-type ameloblastoma were evaluated in the present study. Of them, 5 had areas suspected of indicating a solid component on T1WI and T2WI (or STIR). Ten had undergone additional CE-T1WI and DCE-MRI. On 5 of 10 cases of CE-T1WI, a tiny enhancement area was detected. On 6 of 10 DCE-images, a time-course enhanced area which was suspected to be a solid component was detected. CE-T1WI was helpful in the diagnosis of ameloblastoma because the tiny enhanced areas were taken to indicate possible solid components. Moreover, the rim-enhancement area on CE-T1WI could be divided into small regions of interest, and some of these showed slightly increased enhancement on DCE-MRI, which was taken to indicate a solid component and/or intramural nodule with focal invasion of ameloblastoma tissue. DCE-MRIs of the four remaining cases, which provided no clues to the diagnosis of ameloblastoma in the manner of the above descriptions, showed thicker rim enhancement than odontogenic cysts. Thus, CE-T1WI and DCE-MRI were helpful in the differential diagnosis of unilocular cystic-type ameloblastomas with homogeneously bright high signal intensity on T2WI or STIR. (C) 2010 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.oraloncology.2010.11.009

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：岡山歯学会  

角化嚢胞性歯原性腫瘍(KCOT)の診断におけるMRIのT1強調像の有用性について検討した。顎骨の歯原性腫瘍あるいは歯原性嚢胞の画像診断で外科的手術を施行し、KCOTと病理診断し、生検前にMRI検査を受けていた22例に対して後ろ向き調査を行った。T1強調像における嚢胞内容物が正のコントラストを示した症例は18例、4例のみが負のコントラストを示した。単房性と多房性のコントラストの差は有意ではなかった。コントラストと近遠心径の間とコントラストと頬舌径の間に相関関係は認めなかった。

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Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：岡山歯学会  

2008年1月〜2010年9月にインプラント治療を希望して受診しパノラマX線撮影が行われた患者500例を対象に、患者背景やX線所見について統計学的に検討した。性別は男性192例(38%)、女性308例(62%)であった。年齢は17〜87歳(平均57.4歳)で、50〜60歳代が多く69%を占めていた。インプラント希望歯数は、1本の患者が125例(25%)、2本が114例(23%)、3本が79例(16%)、4本が54例(11%)、5本以上が128例(26%)であった。インプラント希望部位を年齢別にみると、若年層で前歯部が多く、高齢者で臼歯部が多いという特徴が認められた。X線で歯欠損以外の異常所見を認めたものが325例(65%)あり、内訳は歯根膿瘍307例(61%)、歯根膿瘍と他の異常所見が重複しているもの24例(5%)、歯根膿瘍以外の所見18例(4%)であった。歯根膿瘍は1患者平均2.05本認め、インプラント希望部位の隣在歯に認めたものが79例(16%)あった。

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPRINGER  

Aneurysmal bone cysts (ABCs) are classified as bone-related lesions based on the 2005 World Health Organization histological classification of odontogenic tumors. Most ABCs are diagnosed using a combination of conventional radiography, computed tomography, magnetic resonance imaging (MRI), and digital subtraction angiography. ABCs should be differentiated from true cysts or other pseudocysts because their treatment is different. Additionally, unlike other cysts, ABCs pose a hemorrhagic risk in surgery; thus, preoperative evaluation of intralesional blood flow is required. Here we report a case of a mandibular ABC in a 39-year-old woman and focus on its dynamic contrast-enhanced MRI (DCE-MRI) features. On DCE-MRI, the lesion was divided into two areas according to the enhancement pattern: the blood-pooling and blood-flow areas. The series of DCE-MR images of the blood-pooling area showed marked enhancement of the margin, but no enhancement in the inner part of the cavity. Additionally, the time-signal intensity curve (TIC) demonstrated no change in the signal intensity (SI) until approximately 15 min after gadolinium-diethylenetriamine penta-acetic acid (Gd-DTPA) administration. In contrast, the series of DCE-MR images of the blood-flow area exhibited marked enhancement in the cyst cavity in the early phase. The TIC showed a rapid increase in SI in the early phase, followed by a rapid decrease until 150 s, and finally a gradual decrease until approximately 15 min after Gd-DTPA administration. Thus, in the current patient, preoperative DCE-MRI clearly delineated the vessel-rich area within the lesion.

DOI： 10.1007/s11282-010-0048-3

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Introduction. It can be difficult to differentiate simple bone cysts (SBCs) from true cysts in the jaw when these lesions appear unilocular. The present study reports the MR imaging of subjects with SBCs and describes the diagnostic value of the MRI findings.
Materials and methods. Ten subjects with SBCs in the jaw were examined using MRI. T1- and T2-weighted images (T1WI, T2WI) were obtained, and contrast-enhanced images and dynamic contrast-enhanced MRI (DCE-MRI) were acquired.
Results. In all cases, the contrast-enhanced T1WI acquired approximately 6 minutes after the administration of GdDTPA showed marked enhancement of the margin and slight enhancement of the inner part of the cyst cavity. In all cases, the time-signal intensity (SI) curves show a gradual increase in the SI until approximately 15 minutes after the administration of Gd-DTPA. These findings might not be observed on the DCE-MRIs of the other true cysts with epithelial lining that show no enhancement in a cavity.
Conclusion. MRI, especially DCE-MRI, can provide useful information for distinguishing SBCs from other cysts. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;110:364-369)

DOI： 10.1016/j.tripleo.2010.05.001

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Malignant fibrous histiocytoma (MFH) is recognized as one of the most common soft tissue sarcomas arising in late adulthood. Most MFHs arise from the extremities and the retroperitoneum, thus the incidence of head and neck MFH is relatively low. Because of its rare incidence, there are very few reports focusing on the imaging features of MFH arising in the maxillary sinus. A case of MFH of the maxillary sinus in a 67-year-old male patient is reported including imaging and pathological features. © 2010 Mosby, Inc. All rights reserved.

DOI： 10.1016/j.tripleo.2009.11.032

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE BV  

We evaluated the relationship between histopathological prognostic factors, tumor proliferation microvessel density (MVD), and enhancement parameters in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in oral squamous cell carcinoma (SCC). Twenty-eight T2 and T3 patients with primary oral SCC underwent DCE-MRI using three-dimensional fast imaging with a steady-state precession sequence. Tumor cell proliferation and MVD of all surgical specimens were evaluated using immunohistochemical staining with CD34 and the antibody for proliferating cell nuclear antigen (PCNA). Regression analysis was used to statistically analyze the relationship between the PCNA labeling index or MVD and each of three DCE-MRI parameters: maximum CI (CI-max), maximum CI gain (CI-gain) and the CI-gain / CI-max ratio. The PCNA labeling index and MVD showed significant correlations with the CI-gain/CI-max ratio (P = 0.0012, r = 0.581 and P = 0.00141, r = 0.574, respectively). The assessment of DCE-MRI parameters may prove to be a valuable non-invasive method for assessing tumor cell proliferation and MVD of patients with oral cancer. (C) 2008 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.oraloncology.2008.09.003

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OBJECTIVES: To compare MRI manifestations according to gender and age and to identify correlations between clinical manifestations and MRI findings in patients with temporomandibular disorder (TMD) as based on a large series. MATERIALS AND METHODS: Fat suppressed oblique sagittal images of the open and closed mouth were acquired, and MRI scanning parameters were applied. RESULTS: The patients consisted of 946 females (average, 36.6 years old), and 319 males (average, 34.3 years old). In all TMD patients, 945 had symptoms in the unilateral temporomandibular joint (TMJ) and 320 in the bilateral TMJ. There were significant differences in the distribution of disk positions based on age, regardless of gender, in the unilaterally and bilaterally symptomatic groups; however, the results were not significant in the asymptomatic group. There were significant differences with respect to the distribution of disk positions between males and females in asymptomatic group and in the unilaterally symptomatic group, although the bilaterally symptomatic group did not show significant differences in this regard. As regards the disk positions in the joints of the three groups (asymptomatic group, unilaterally and bilaterally symptomatic groups), there were significant interactive effects of disk positions, regardless of gender. There were statistically significant age-related differences in disk deformities in all symptom groups, regardless of gender, except for in the group of males lacking symptoms in either joint. As regards disk deformities among the three groups studies here, there were significant interactive effects for disk positions, regardless of gender.

DOI： 10.2174/1874210600903010001

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Language：Japanese   Publishing type：Research paper (scientific journal)  

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Odontoma is the most common type of benign odontogenic tumor, and often causes disturbances in the eruption of its associated tooth. Odontomas usually occur in the permanent dentition, and rarely occur solely in the primary dentition. This case report documents a six-year-old-child with a compound odontoma located in the mandible, which caused the impaction of the primary second molar.

DOI： 10.2174/1874210600903010173

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：BRITISH INST RADIOLOGY  

Objectives: To examine Oral and maxillofacial lesions other than those related to the chief complaint in panoramic radiographs taken at the department of paediatric dentistry at our hospital.
Methods: We retrospectively reviewed all 1092 patients who had visited the department of paediatric dentistry at our hospital and had a panoramic radiograph taken between August 1999 and October 2004. The following information was obtained from the patients' files and panoramic radiographs: gender, age, chief complaints and the presence or absence of lesions.
Results: Lesions were observed in 140 of the 1092 panoramic radiographs (12.8%). Among the 140 patients discovered to have lesions in the panoramic radiographs, 66 (47.1%, or 6.05% of the entire group Of 1092 patients) had different lesions from those underlying the chief complaint. These 66 patients ages ranged from 3 years to 14 years and the lesions involved 39 (59.1%) missing teeth, 20 (30.3%) mesiodentes, 4 supernumerary teeth, I odontoma, I radicular cyst and 1 impacted tooth. The missing teeth were observed in the central and lateral incisor, canine, and first and second premolar positions of both jaws, especially in the lower lateral incisor and upper central incisor positions.
Conclusions: We were able to detect incidental lesions at a rate of 6.05% (66 of 1092 patients) and at a relatively early age (mean 6.8 years) in the present study. Early treatment of these lesions could avoid maxillofacial deformity and other complications.

DOI： 10.1259/dmfr/31214423

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Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：岡山歯学会  

2006年4月〜2008年9月にPET撮影を行った頭頸部悪性腫瘍患者121名173例(男68名、女53名、年齢29〜89歳)を対象に検討した。半年毎の患者数は22例、32例、42例、38例、39例と推移し、術後の割合が36.4%、46.9%、57.1%、60.5%、64.1%と増加傾向を示した。原発巣は術前78例中73例(93.6%)にFDGの異常集積を認め、偽陰性5例は4例が上皮内癌からT1の表在性の悪性腫瘍で、1例が高血糖であった。術後94例中16例(17.0%)に異常集積を認め、表在性の悪性腫瘍1例は偽陰性であった。リンパ節は術前初発症例78例中24例(30.8%)、術後では94例中19例(20.2%)に異常集積を認め、偽陰性3例(1.7%)は高血糖1例、内部壊死を起こした2例であった。遠隔転移は7例で、2例は胸部CTで既に疑われており、5例はPET検査で認識でき、重複癌である多臓器原発の悪性腫瘍2例、原発性肺癌2例を認めた。以上より原発巣、所属リンパ節転移、遠位転移、重複癌の検出にPETの有用性が示されたが偽陰性も少なからずあることから、他のモダリティとの組み合わせにより診断能を向上させることが必要と考えた。

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE BV  

To evaluate the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI) in salivary gland tumors, thirty-five patients (47 lesions) who underwent MR examinations and were histopathologically diagnosed with salivary gland tumors in Okayama University Hospital, between April 1998 and March 2005, were entered in the present study. The parameters included CImax300 or CImax6003 which was the contrast index (CI) at maximal contrast enhancement upon 300 s or 600 s, and T-max, which was the time that corresponded to the CImax300. Washout ratio (WR300 or WR600) was defined as follows: CImax300 - CI300s/CImax300 or CImax600 - CI600s/CImax600 X 100 (%), where CI300 or CI600 was the CI at 300 s or 600 s after contrast medium administration. We obtained the following results from the analysis of DCE-MRI parameters; (a) The salivary gland tumors were categorized into three Cl curve types according to Tmax and WR300; Pleomorphic adenoma; Tmax &gt; 210 s and WR300 &lt; 10%, Warthin tumor; Tmax &lt; 60 s and WR300 &gt; 40%, and malignant tumor; 60 s &lt; Tmax &lt; 210 s and 10% &lt; WR300 &lt; 30%; (b) On the basis of the relationship between Tmax and CImax or WR, all pleomorphic adenomas were successfully differentiated from Warthin tumor lesions. Of the 20 pleomorphic adenomas, 18 (90.0%) were successfully differentiated from malignant tumors. All Warthin tumor lesions were successfully differentiated from pleomorphic adenomas and malignant tumors. Of 12 the malignant tumors, 11 (91.7%) were successfully differentiated from pleomorphic adenomas. All malignant tumors were successfully differentiated from Warthin tumors. Thus, DCE-MRI parameters are useful in diagnosing salivary gland tumors on the basis of the combined assessment of Tmax and CImax or WR. (c) 2006 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.oratoncotogy.2006.11.009

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Objectives. We rarely find multiple cystic lesions in the jaw in panoramic radiographs. Most reports of multiple cystic lesions have described keratocystic odontogenic tumors (KOTs) in patients with basal cell nevus syndrome. In this study, we performed radiographic and clinical examinations of patients with multiple cystic jaw lesions found during their first visit to our department to determine the proportion of basal cell nevus syndrome among multiple cystic lesions. Methods. Patients who had a panoramic radiograph taken at Okayama University Hospital between 1993 and 2000 were examined. Twenty-three patients with multiple cystic jaw lesions on a first panoramic radiography examination were entered into this study. Results. Of the 23 patients, 12 (52.2%) were diagnosed with basal cell nevus syndrome and 11 (47.8%) were not. Of the 14 patients with multiple KOTs, 12 (85.7%) were diagnosed as having basal cell nevus syndrome. Of the nine remaining patients with multiple cystic jaw lesions, only seven had multiple dentigerous cysts and two had multiple simple bone cysts. Cleft palate was observed in four of the 12 patients (33.3%) with basal cell nevus syndrome. Conclusion. Diagnosing basal cell nevus syndrome based on multiple cystic jaw lesions carries a high risk of misdiagnosis. A strong possibility exists that patients with multiple jaw KOTs have basal cell nevus syndrome. Furthermore, cleft palate should be considered an important oral finding in basal cell nevus syndrome because its occurrence was relatively frequent in our study. © 2007 Japanese Society for Oral and Maxillofacial Radiology Springer-Verlag.

DOI： 10.1007/s11282-007-0059-x

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：PROFESSOR D A SPANDIDOS  

We attempted to find a specific antigen of oral squamous cell carcinoma (SCC) cells that could be safely applied to gene therapy in the conservative clinical treatment of oral cancer. We performed subtraction using normal human keratinocyte cells, followed by selection using four oral SCC cell lines. We isolated three clones from poorly differentiated SCC cells and four from well-differentiated SCC cells. These seven clones adsorbed to the oral SCC cells at rates 10-100 times those of normal human keratinocyte cells. The three clones from the poorly differentiated SCC cells showed the same peptide sequence (LAPRTHP). Of the four clones from the well-differentiated SCC cells, three showed the same peptide sequence (FGTLPGT) and the fourth showed a different one (VTPNSTP). Each peptide sequence may recognize the material that exists specifically on the oral SCC cell cortex. We can expect applications not only for tumor-targeting treatment using a gene therapy virus vector but also for diagnosis using, as a tumor marker, the peculiar SCC surface material that these peptides recognize.

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER IRELAND LTD  

Purpose: To examine whether the signal intensity of dynamic contrast-enhanced MRI (DCE-MRI) is altered by test injection of 1 ml of contrast medium, and if so, whether this change affects the DCE-MRI analysis.
Materials and methods: Six healthy volunteers were examined by DCE-MRI using a Magnevist syringe and/or an Omniscan syringe for the injection of contrast medium. Each scan was performed 10 times using steady-state free precession (3D-FISP), a sequence for DCE-MRI, before and after intravenous injection of 1 ml of the contrast medium. The internal pterygoid muscle, masseter muscle, tongue, parotid gland, submandibular gland, bone marrow of the mandible, subcutaneous adipose tissue, and common carotid artery were determined to be regions of interest (ROI), and the ROI internal average signal intensity was measured. The 10 data sets obtained before or after contrast medium administration for each ROI were evaluated using the paired t-test.
Results: The test injection increased the signal intensities of six of eight ROIs, with all 20 experiments in the submandibular gland showing significant differences. There was no significant difference in the two ROIs corresponding to the carotid artery and subcutaneous adipose tissue of the cheek.
Conclusions: The enhanced signal intensity in the tissue might have been caused by the small amount of contrast medium in the test injection. To eliminate this discrepancy caused by the test injection, a pre-contrast scan should be performed when the average signal intensity of an ROI is measured. We therefore believe that the data obtained before a test injection may be important in the analysis of DCE-MRI. (C) 2006 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.ejrad.2006.03.017

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE BV  

The radiographic features of unicystic ameloblastoma (UA) are typically unilocular and round area of radiolucency. Therefore, this type of lesion is often misdiagnosed as an odontogenic keratocyst or a dentigerous cyst. UA should be differentiated from odontogenic cysts because the former have a higher rate of recurrence than the latter. In the present study, we performed contrast enhanced-MRI (CE-MRI) to diagnose 13 cases of unilocular, round radiolucent lesions visualized on panoramic radiograph and/or CT. In the cases of UA, low signal intensity was observed on T1-weighted images (WIs), and a markedly high signal intensity was observed on T2-WIs; moreover, relatively thick rim-enhancement with/without small intraluminal nodules was observed upon CE-T1 WIs. CE-MRI was considered useful in the diagnosis of UA, as characteristic features of this type of Lesion i.e., thick enhancement of the tumor wall and small intraluminal nodules were detected only by CE-MRI in the present study. (c) 2005 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.oraloncology.2005.10.001

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：BRITISH INST RADIOLOGY  

A case of recurrent ameloblastoma developing in an autogenous iliac bone graft 20 years after radical resection of primary mandibular ameloblastoma is presented. This case showed extensive bony resorption extending throughout the auto-grafted bone. Seeding to the graft bone was suspected as a cause of the recurrence in the iliac bone graft because wide destruction of the graft bone was observed without any prior signs and symptoms of intraoral mucosa. Consequently, extensive resection of bone as well as adjacent soft tissue was performed. Persistent follow-up examination is essential for management of ameloblastoma.

DOI： 10.1259/dmfr/13828255

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：BRITISH INST RADIOLOGY  

We present a case of a 10-year-old girl with neurofibromatosis type I related skeletal dysplasia. In the present case, a unilocular radiolucency at the left coronoid notch visible on a panoramic radiograph was suspected to be a neurofibroma. However, only the presence of bone deformities was observed on CT. Fat-like tissue adjacent to the bone deformities inside the left mandibular ramus was revealed, and the presence of neurofibroma was unequivocally denied on the MR images. However, biopsy of the lesion suggested neurofibroma. The diagnostic imaging 18 months after the first visit did not revealed a tumourous mass. However, careful follow up is required even though we could not prove the presence the lesion on the basis of imaging.

DOI： 10.1259/dmfr/46427075

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER IRELAND LTD  

We retrospectively evaluated magnetic resonance images (MRI) and dynamic contrast-enhanced MRI (DCE-MRI) of ameloblastomas. MRI and DCE-MRI were performed for 10 ameloblastomas.
We obtained the following results from the MRI and DCE-MRI. (a) Ameloblastomas can be divided into solid and cystic portions on the basis of MR signal intensities. (b) Ameloblastomas show a predilection for intermediate signal intensity on T1WI, high signal intensity on T2WI, and well enhancement in the solid portion; they also show a homogeneous intermediate signal intensity on T1WI and homogeneous high signal intensity on T2WI, and no enhancement in the cystic portion. (c) The mural nodule or thick wall can be detected in ameloblastomas lesions. (d) CI curves of ameloblastomas show two patterns: the first pattern increases, reaches a plateau at 100-300 s, then sustains the plateau or decreases gradually to 600-900 s, while the other increases relatively rapidly, reaches a plateau at 90-120 s, then decreases relatively rapidly to 300 s, and decreases gradually thereafter. There was no difference in the Cl curve patterns among primary and recurrent cases, a case with glandular odontogenic tumor in ameloblastoma. or among histopathological types such as plexiform, follicular, mixed, desmoplastic, and unicystic type. (C) 2005 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.ejrad.2005.01.006

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Objectives. Various types of lesion have been reported in the submental region, but submental masses can be difficult to diagnose. Our objective was to attempt to diagnose submental masses by using magnetic resonance imaging (MRI) along with clinical data. Methods. We attempted to diagnose seven cases in which the chief complaint was submental swelling
diagnosis was carried out on the basis of features visualized by MRI. Results. Seven types of lesions were observed: phlegmone and abscess caused by osteomyelitis
epidermoid cyst
thyroglossal duct cyst
abscess-forming granulomatous lymphadenitis
T-cell lymphoma (suspected Hodgkin's disease)
non-Hodgkin's B-cell lymphoma
and lymph node metastasis from squamous cell carcinoma in the tongue. Conclusions. The magnetic resonance images of each lesion revealed characteristic features. Thus, MRI may be useful for the differential diagnosis of submental swelling before the initiation of treatment. © Japanese Society for Oral and Maxillofacial Radiology Springer-Verlag Tokyo 2005.

DOI： 10.1007/s11282-004-0021-0

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Language：Japanese   Publisher：岡山歯学会  

病理組織学的に好酸球肉芽腫と診断した4例を対象とした.主訴は4例中2例が腫脹,1例が疼痛,1例がX線撮影時に偶然発見されたものであった.臨床的・X線学的に4例中2例は悪性腫瘍,1例は骨髄炎と診断され,1例は不明であった.最終的には病理組織学的に全例,好酸球肉芽腫と診断した.X線学的には,顎骨内に生じた14病巣はび漫性のX線透過像を示した.処置は8病巣で掻爬あるいは辺縁骨切除などの外科処置,4病巣で放射線照射,3病巣で化学療法,2病巣で外科処置と放射線照射,3病巣で放射線照射と化学療法を行った.いずれの処置に対してもよく反応したが,化学療法に関しては悪性リンパ腫の診断の基に行ったもので,反応は悪かった.外科処置のみを行った4病巣に再発を生じたが,放射線照射および外科処置と放射線照射の併用によって制御された

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The radiographical differentiation of adenomatoid odontogenic tumor (AOT) from dentigerous cysts, calcifying odontogenic cysts, calcifying epithelial odontogenic tumors, odontogenic keratocysts and amelobastomas is sometimes difficult. We attempted to differentiate AOT from other lesions similar to AOT in radiographic findings using MRI. The MRI features of AOT in our three cases included homogeneous low SI in the cystic portion and homogeneous intermediate SI in the solid portion on T1WI, homogeneous high SI in the cystic portion and intermediate to slightly high SI in the solid portion on T2WI and enhancement of only the solid portion on CE-T1WI although none of the sequences included SI of calcifications. The contrast index curves in the three cases of AOT showed a gradual increase to 300 s, which signified a benign tumor. These MRI features were characteristic features of AOT and might be a basis for differentiating AOT from the above possible lesions in radiographic examinations. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.ejrad.2003.09.009

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：PERGAMON-ELSEVIER SCIENCE LTD  

Because malignant lymphoma, the second most common malignant tumor of the head and neck, and squamous cell carcinoma (SCC), the most common malignant tumor of the head and neck, require different treatments, it is important to be able to differentiate them. In the present study, we attempted to differentiate malignant lymphomas from SCCs using dynamic contrast-enhanced MRI (DCE-MRI). Seventeen lesions (in 8 cases) of malignant lymphoma and 30 cases of SCC were compared by DCE-MRI.
Thirteen of 17 malignant lymphomas (76.5%) showed the maximum contrast index (CI) at 90-180 s, while 26 of 30 SCCs (86.7%) showed the maximum Cl at a much faster 60-105 s. There was a statistically significant difference between SCC and malignant Lymphoma in the time needed reach the maximum CI (p = 0.0177). There was also significant difference between SCC and malignant lymphoma in their maximum Cls (p &lt; 0.001), with the maximum Cls of 29/30 SCCs (96.7%) above 2.0, while 12/17 malignant lymphomas (70.6%) showed Cis of less than 2.0. We consider these findings to be useful for distinguishing lymphomas from SCCs. (C) 2003 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.oraloncology.2003.12.002

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Objectives: To examine mesiodens with regard to their status, their influence on adjacent teeth and their alteration during the follow-up period.
Methods: From retrospective reviews of all patients who visited our institution from 1990-2001, we identified 200 patients (256 mesiodentes) who were shown to have mesiodentes on the basis of a periapical radiograph, a panoramic radiograph or an axial radiograph.
Results: The number of supernumerary teeth was one in 146 cases (73%), two in 5 2 cases (26%) and three in 2 cases (1%). Of 256 mesiodentes, the direction of the crown of the mesiodens was inverted in 172 (67%), in a normal direction in 69 (27%) and in a horizontal direction with regard to the tooth axis in 15 (6%). Of the 147 mesiodentes for which axial radiography was performed, 131 (89%) were located at a palatal site against the dental arch, 16 (11%) overlapped the dental arch and none were at a labial site. Of our 200 cases, a delay of eruption of the permanent central incisor was seen in 12 (6%), malposition or rotation of the central incisor in 5 (2.5%) and dentigerous cyst formation arising from mesiodens in 22 (11%). Marked movement of the mesiodens was seen in 10 cases during the follow-up period of 5-7 years. Some complication arising from mesiodens was seen in 19.5% of all cases in our research.
Conclusion: Although mesiodentes are not caused by malocclusion, they may cause it. A long period of impaction of mesiodentes may bring about dentigerous cyst formation or movement of the mesiodentes.

DOI： 10.1259/dmfr/68039278

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Objectives: To examine radiographically the relationship between the deciduous tooth and dentigerous cyst of the permanent successor during the transitional dentition.
Methods: From a retrospective review of all patients who visited our institution from April 1988 to August 2001, 70 patients under 16 years of age who had histologically confirmed dentigerous cysts that had developed from the central incisor to the second premolar were identified. These 70 patients were investigated using panoramic and periapical radiographs.
Results: Inmost cases (54 cases; 77.1%) the cyst was in the premolar region. Of the 54 premolars with dentigerous cysts, the overlying deciduous tooth had already been lost in 7 cases. Of the 47 remaining premolars with associated deciduous tooth, 35 (74.5%) had bone resorption of the periapical or bifurcation region, or irregular resorption of the associated deciduous tooth. Of the remaining 12 deciduous teeth with no periapical lesions, 9 had been treated with root canal therapy. Thus, 44 of these 47 cases (93.6%) had the possibility of inflammation at the deciduous tooth associated with the dentigerous cyst. Evidence from one case in the present study suggesting the process by which cyst development occurs is also given.
Conclusion: Inflammatory change at the apex of the deciduous tooth may bring on a dentigerous cyst of the permanent successor.

DOI： 10.1259/dmfr/24148363

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：(一社)日本口腔診断学会  

28歳男性.エナメル上皮腫と含歯性嚢胞が同時性に発生した1症例を経験したので報告した.患者は左側上顎側切歯の自発痛を主訴に来院し,X線検査により,上顎前歯部と左側第三大臼歯部に単房性X線透過像を認めた.そして,病理組織診断にて,上顎前歯部は含歯性嚢胞,左側第三大臼歯部はエナメル上皮腫の診断が得られた

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In this study, we attempted to diagnose malignant lymphoma on the basis of magnetic resonance imagings (MRIs) and dynamic contrast-enhanced MRI (DCE-MRI). Eighteen lesions (in eight patients), all of which had been proven histopathologically, were detected on MRI. The eight patients included five patients with diffuse large B-cell lymphoma, one with B-cell low-grade MALT lymphoma, one with follicular lymphoma, and one with Hodgkin's lymphoma. Nine lesions were located in the submandibular region, three in the buccal region, two in the orbit region, two in the submental region, and one each in the palatal and tonsil regions. The diameter of the lesions ranged between 9 and 42.2 mm (average: 22.4 mm). The signal intensities (SIs) of the 18 lesions were examined on T1-weighted (T1WI), T2WI, and gadopentetate (Gd)-T1WI. One lesion in case 8 was excluded from DCE-MRI findings, i.e., the regions of interest could not be adequately set on DCE-MRIs. The contrast index (CI) curves of the remaining 17 lesions were prepared. All 18 lesions showed almost the same images on T1WI, T2WI, and Gd-T1WI, although they represented four types of lymphoma. The images showed homogeneous SI that was intermediate to slightly high SI on T1WI, slightly high SI on T2WI, and moderately enhanced on Gd-T1WI. Thus, the cases of malignant lymphoma in this study showed relatively characteristic features based on MRI; however, these features might be non-specific. The CI curves in this study showed a relatively rapid increase, reaching a maximum CI at 45-120 s, and a relatively rapid decrease in most lesions (14/17; 82.4%); on the other hand, the curves of 3 of the 15 lesions (17.6%) showed relatively rapid increase, sustenance of a plateau, and a gradual decrease thereafter. These patterns of CI curves may indicate characteristic features useful for distinguishing malignant lymphomas from other lesions. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

DOI： 10.1016/S0720-048X(02)00347-9

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCI IRELAND LTD  

The aim of the present study was to review the magnetic resonance (MR) appearance of primary epithelial cysts in order to distinguish the cysts from other possible lesions. MR images were obtained in 27 cases of epithelial cysts, including 7 odontogenic keratocysts, 3 dentigerous cysts, 1 glandular odontogenic cyst, 10 radicular cysts, 4 nasopalatine duct cysts, and 2 nasolabial cysts. In addition, contrast enhanced MR imagings were performed in 12 cases, including 3 odontogenic keratocysts, 1 dentigerous cyst, 1 glandular odontogenic cyst, and 7 radicular cysts. We obtained the following results on the basis of the above MR and contrast enhanced MR findings. (a) Odontogenic keratocysts had a predilection for intermediate-high signal intensity (SI) on T1-weighted images (WI) and heterogeneous low-high SI on T2WI. (b) Dentigerous cysts, glandular odontogenic cyst, radicular cysts and nasolabial cysts showed the same predilection with the SI which were homogeneous intermediate SI on T1WI and homogeneous high SI on T2WI. (c) The MR images of the nasopalatine duct cysts, which showed homogeneous high SI on T1WI, were specific. (d) The Gd-T1WI would be useful in decisively differentiating odontogenic cysts, which showed rim-enhancement, from tumors consisting of solid components. In conclusion, we were able to obtain more information from the MR and contrast enhanced MR images than from conventional radiograph findings. (C) 2002 Elsevier Science Ireland Ltd: All rights reserved.

DOI： 10.1016/S0720-048X(02)00218-8

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：PERGAMON-ELSEVIER SCIENCE LTD  

We evaluated magnetic resonance images (MRI) and the value of dynamic contrast enhanced MRI (DCE-MRI) of pleomorphic adenomas retrospectively. MRI was performed for 18 pleomorphic adenomas, including 11 cases with DCE-MRI. We obtained the following results on the MRI and DCE-MRI. (a) Pleomorphic adenomas showed a predilection for homogeneous intermediate signal intensity on T1-weighted images (T1WI), heterogeneous high signal intensity on T2-weighted images, and heterogeneous enhancement on Gd-T1WI. (b) Of 11 contrast index (CI) curves of pleomorphic adenomas, nine CI curves (81.8%) increased gradually to 600 s or increased gradually, reached a plateau, and sustained the plateau to 600 s. The remaining two (18.2%) increased gradually and decreased gradually thereafter. (c) CI curves reached the maximum CI index at 135-300 s. (C) 2003 Elsevier Science Ltd. All rights reserved.

DOI： 10.1016/S1368-8375(03)00040-X

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We examined the frequency of incidentally found or unexpected tumors discovered at the time of magnetic resonance imaging (MRI) examinations in the temporomandibular joint (TMJ) region for patients with suspicion of TMJ arthrosis. Five MR images (T1-weighted transverse scout image and proton density and T2-weighted oblique sagittal images at the open and closed mouth) were acquired. In 2776 MRI examinations of TMJ arthrosis, two tumors were discovered. They consisted of an adenoid cystic carcinoma in the deep portion of the parotid gland, and a malignant tumor extending from the infratemporal fossa to the parapharyngeal space. The rate of incidentally founded or unexpected tumors in TMJ examinations was low (0.072%), but the two tumors found were malignant tumors, and therefore, scout image should be carefully examined, not only used for positing the slice. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

DOI： 10.1016/S0720-048X(03)00095-0

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：BLACKWELL MUNKSGAARD  

Lesions that can produce divergence of the roots of teeth in the mandible include odontogenic cysts (odontogenic keratocysts, lateral periodontal cysts and radicular cysts), ameloblastomas, odontogenic myxomas, central giant cell granulomas, adenomatoid odontogenic tumors and aneurismal bone cysts, and other tumors. Moreover most benign jaw lesions can do this occasionally. However, when lesions - which show interradicular tear-shaped radiolucencies - are small it is often difficult to interpret them radiographically, because they do not show characteristic radiographic features. We describe a comparison of radiographic and magnetic resonance (MR) features of a root-diverging odontogenic myxoma, with discussion of the differential diagnosis of lesions likely to move roots. In addition, we discuss radiographic and MR features of possible lesions, which show similar radiographic findings to odontogenic myxoma.

DOI： 10.1034/j.1601-0825.2003.01802.x

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：PROFESSOR D A SPANDIDOS  

We report herein the effects of p53 gene therapy in the radiotherapy or thermotherapy of eight human head and neck squamous cell carcinoma (SCC) cell lines. The discrepancy between radiosensitivity combined with p53 gene therapy than that without p53 gene therapy increased among the eight SCC cell lines. The discrepancy increased in the thermosensitivity at 43degreesC and decreased in that at 44degreesC among the eight SCC cell lines. Thus, the p53 gene therapy did not always improve the discrepancy between radiosensitivity and thermosensitivity in the eight SCC cell lines. In the radiotherapy combined with adenoviral p53 gene therapy, the survival rates of three of eight SCC cell lines decreased, and that of only one cell line increased compared with radiotherapy alone. In thermotherapy combined with p53 gene therapy, the survival rates of three at 44degreesC and five at 43degreesC of the eight SCC cell lines decreased, although only one cell line at 43degreesC increased its survival rate compared with thermotherapy alone. The p53 gene therapy decreased the survival rates of both radiotherapy and thermotherapy in three of eight SCC cell lines. Further, the distribution of plots on the basis of the time for 10% survival of radiotherapy and the dose for 10% survival of thermotherapy with p53 gene therapy shifted to the lower left side of the plots compared with those without p53 gene therapy. These findings indicated that p53 gene therapy improves the effects of both radiotherapy and thermotherapy.

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We investigated the relationship between the enhanced patterns acquired by dynamic MRI and the tumor cell proliferation estimated by immunostaining proliferating cell nuclear antigen (PCNA) in oral squamous cell carcinoma (SCC). Thirty patients with primary oral SCC underwent dynamic contrast enhanced (DCE)-MRI using a three-dimensional fast imaging with steady-state precession sequence. Tumor cell proliferation of all surgical specimens was evaluated using immunohistochemical staining with the anti-PCNA antibody. The relationship between the dynamic MRI parameters (maximum CI and maximum CI gain) and the PCNA labeling index was statistically analyzed using regression analysis. The time contrast index curves of all cases showed a rapid and high uptake pattern. The PCNA labeling index showed a significant correlation with maximum CI and maximum CI gain (P&lt
0.0001, r=0.866 and P=0.0019, r=0.544, respectively). The assessment of DCE-MRI parameters may provide valuable information for tumor cell proliferation of the patients with oral cancer. © 2003 Elsevier Science Ltd. All rights reserved.

DOI： 10.1016/S1368-8375(02)00119-7

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：PROFESSOR D A SPANDIDOS  

We examined effects of recombinant p53-expressing adenovirus combined with thermoradiotherapy in 8 head and neck squamous cell carcinoma (SCC) cell lines to improve the outcomes of the threatment of advanced head and neck cancer. The p53 gene therapy did not improve the discrepancy between thermoradiosensitivities among the 8 SCC cell lines. However, p53 gene therapy improved the effects of thermoradiotherapy in all 8 cell lines, and there were significant differences in four situations of the HSC4 44degreesC (p=0.032), SAS at 44degreesC (p=0.029), the KB at 43degreesC (p=0.025), and the Ca9-22 43degreesC (p=0.020). In comparing the survival rates of thermoradiotherapy with those of thermotherapy and radiotherapy, thermoradiotherapy demonstrated actual survival rates less than theoretical survival rates based on the survival rates of thermotherapy multiplied by the survival rates of radiotherapy in almost all treatments of thermoradio-gene therapy of the 8 SCC cell lines. These results demonstrate that thermoradiotherapy combined with p53 gene therapy may be a useful tool in treating SCC cells.

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Aneurysmal bone cyst (ABC) is a relatively rare, non-neoplastic expansile lesion of bone. Bleeding may occur during an operation or biopsy for ABC, as this cyst is an aneurys with numerous pools of blood. Therefore, it is necessary to diagnose ABC before treatment or biopsy. In the present report, we describe the characteristic computed tomography (CT) and magnetic resonance imaging (MRI) features of ABC in the mandible. Based on the literature and on our own experiences, we compare with the features of ABC with the corresponding features of other lesions showing similar conventional radiographic appearances. In the present case, bone-targeting CT showed the characteristic feature, which reflected the histopathological appearance of a partially cystic meshwork divided by coarse septa. MRI showed almost homogeneous intermediate signal intensity, including a partial slight low-signal-intensity area on the T1-weighted image, and homogeneous high signal intensity, which showed a 'bubbly' appearance, on T2-weighted image. On the enhanced T1-weighted image, the intermediate signal intensity areas apart from the areas that showed slight low-signal intensity on the non-enhanced T1-weighted image, were well enhanced. This creates a 'honeycomb' appearance. The 'meshwork' appearance on bone-targeting CT, the 'bubbly' appearance on the T2W1 and the 'honeycomb' appearance on Gd-T1WI may be the characteristic features of ABC. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

DOI： 10.1016/S0720-048X(02)00008-6

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We report on thermoradiotherapy combined with p53 gene therapy in the human salivary gland adenocarcinoma cell line HSG. HSG cells were successfully infected at a rate of 62.3% with MOIs of 20 of either AxCAip53 or AxCAiLacZ. The AxCAiLacZ did not inhibit the survival of the HSG cells. The survival fractions of AxCAip53-infected HSG cells were lower than those of the AxCAiLacZ-infected HSG cells, but there was no significant difference (p=0.30). AxCAip53 decreased the survival rates of thermotherapy (43degreesC; p=0.084 and 44degreesC; p=0.18), radiotherapy (6 Gy; p=0.20) and thermoradiotherapy (6 Gy plus 43degreesC; p=0.24 and 6 Gy plus 44degreesC; p=0.96), but there were no significant differences. In comparing the survival rates of thermoradiotherapy with those of thermotherapy and radiotherapy, thermoradiotherapy, regardless of the combination with p53 gene therapy, demonstrated actual survival rates lower than theoretical survival rates based on survival rates of thermotherapy multiplied by survival rates of radiotherapy. This result indicates that thermoradiotherapy is effective in the treatment of HSG cells. Thermoradiotherapy combined with p53 gene therapy was the most effective therapy among the combinations of therapies demonstrating that thermoradiotherapy combined with p53 gene therapy may be a useful, tool in the treatment of HSG cells.

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

We describe a case of angioleiomyoma in the buccal space, and discuss its magnetic resonance imaging (MRI) features with histopathological correlation, with particular emphasis on the usefulness of using dynamic contrast-enhanced MRI (DCE-MRI) to differentiate other possible tumors. Angioleiomyoma of the buccal space in this case corresponded clinically and histopathologically to the previous reports. The characteristic findings of angioleiomyoma were a very high signal intensity on T2WI, and extremely high enhancement on Gd-T1WI. The inner aspect of this lesion was homogeneous on both T1WI and T2WI. However, the histopathological findings included tumor substance, mucous degeneration, and mature adipose cells, and these findings were reflected only on the DCE-MRI. Furthermore, the CI-Curve of the angioleiomyoma showed a characteristic pattern, which might differentiate it from other tumors. © 2003 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/S1571-4675(03)00080-4

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

Introduction: It might be difficult to differentiate solitary bone cysts (SBCs) from other cysts and tumors when the lesion occurs at an unusual location and/or shows atypical radiographic features. Magnetic resonance imaging (MRI) is the most useful modality for evaluating the internal structure of lesions and may have the ability to distinguish SBCs from other lesions. However, few studies exist regarding MRI of SBCs in the oral region. The present study reports on the MR imaging of nine patients with SBCs and describes the diagnostic value of the MRI findings. Materials and methods: Nine patients with SBCs in the mandible were examined using MRI. In all patients, T1- and T2-weighted images (T1-WI, T2-WI) were obtained and contrast enhanced images and dynamic MRI were performed in four cases. Results: MR findings revealed homogeneous intermediate signal intensities (SI) on T1-WI and high SI on T2-WI in all cases. These SI indicated that the SBCs included homogeneous liquid. On the dynamic MRIs in all cases, the SBCs were enhanced from the margin to the inner part, indicating a gradual exudation of the contrast agent from the surrounding medullae to the inner part. These phenomena were not observed on the dynamic MRIs of the other true cysts with epithelial lining. Conclusion: MRI, especially dynamic MRI, can provide useful information for distinguishing SBCs from other cysts or tumors. Furthermore, dynamic MRI findings suggested that the liquid components of SBCs might have infiltrated from the surrounding medullae. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

DOI： 10.1016/S1571-4675(03)00021-X

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：PROFESSOR D A SPANDIDOS  

In the present study, we attempted to diagnose and detect the extent of tumors in the sublingual region using magnetic resonance imaging (MRI) and dynamic MRI. MRI with or without gadopentetate dimeglumine (Gd-DTPA)enhancement in seven lesions of the sublingual regions was performed. The seven lesions included four cases of mucoepidermoid carcinoma (mucoepidermoid Ca), two cases of adenoid cystic carcinoma (ACC), and one case of squamous cell carcinoma (SCC). Whether the tumor was malignant or benign, as well as the differential diagnosis, could not be determined on the basis of the MR signals, even when enhancement was performed. Dynamic MRI was performed in five cases, two cases of ACC, two cases of mucoepidermoid Ca, and one case of SCC. The dynamic MRI showed a rapid enhancement at 30-45 sec in all five cases before the normal sublingual gland began to be enhanced. The early phases at 30-45 sec of the dynamic MRI in five cases showed marked enhancement before the normal sublingual glands were enhanced, and therefore could clearly show the extent of the lesions. In conclusion, the dynamic MRI may be useful in differentiating malignant from benign tumors, and in detecting the extent of the tumors in the sublingual carcinomas.

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCI IRELAND LTD  

Objective: To investigate whether dynamic CT enables quantitative differentiation between inflammation, benign tumors, and malignant tumors in oral and maxillofacial regions. Methods: Sixteen malignant tumors (14 squamous cell Ca, one adenoid cystic Ca. one mucoepidermoid Ca) six benign tumors (one Warthin tumor, two pleomorphic adenomas, one lipoma, one Schwanoma, one hemangioma), and seven inflammation cases (three submandibular adenitis, two osteomyelitis, two perimandibular inflammations) were examined. Contrast agent (0.8 ml kg) was injected intravenously at 5 ml s. CT (Toshiba TCT 900S) scanning was performed at the time of the beginning of contrast medium injection. Parameters from the time density curve were investigated: peak height (PH), relative CT value from the base CT value when the curve reached peak point: peak time (PT). the time when the curve reaches the peak point from contrast medium infusion: transit time (TT), time between two transit points on the time-density curve; and peak time ratio (PR), the ratio of peak time from the lesion to the artery and peak time from the vein to the artery. Results: PH was highest in inflammation. followed by malignant tumors and benign tumors TT was significantly longer in benign tumor cases compared with malignant tumor and inflammation cases. PR for malignant tumor and inflammation were between the artery and vein phase, and that for benign tumor was beyond the vein phase. Conclusion: Parametrical analysis of a contrast enhanced dynamic CT study may serve to differentiate the lesions in the oral and maxillofacial region. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

DOI： 10.1016/S0720-048X(01)00369-2

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCI IRELAND LTD  

Adenomatoid odontogenic tumor is a rare benign and odontogenic tumor that is frequently misdiagnosed as other odontogenic cysts and tumors on radiographic examination. To acquire additional information of adenomatoid odontogenic tumor. we performed magnetic resonance imagings (MRI) at a case of adenomatoid odontogenic tumor. The lesion was divided between the peripheral portion with a thick circular shape and the central portion with a round shape on the basis of the signal intensity (SI) of MRI. The peripheral portion showed intermediate SI contained multifocal no SI on T1WI, high SI contained multifocal no SI on T2WI, and heterogeneous enhancement on CE-T1WI. These multifocal areas corresponded to the numerous punctate radiopaque foci shown on computed tomography. The central portion showed homogeneous low SI on T1WI, homogeneous very high SI on T2WI, and no enhancement on CE-T1WI. Macroscopic examination revealed the round shaped lesion included one large cystic space correspondent to the central portion with a clear cystic wall correspondent to the peripheral portion on MRI. The MRI features corresponded to the macroscopic findings of the histopathological examination. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

DOI： 10.1016/S0720-048X(01)00428-4

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCI IRELAND LTD  

A case of 59-year-old male patient presenting with metastasis to the mandible from malignant pheochromocytoma is described. The conventional radiographs and CT images suggested that the lesion was malignant osteogenic tumors or metastatic tumors due to the exstence of calcification and widesoread periosteal sunburst spiculation. On MRI, an expansive mass was clearly depicted and the signal intensities of the lesion were lock to intermediate on T1 weighted image with intermediate to high signal intensity on T2 weighted image. A strong enhancement of the lesion was also observed on contrast enhanced T1 weighted image. On maximum intensity projection image in the arterial phase. the mass showed exceedingly early enhancement and excessively dislocated adjacent vessels. The diagnosis of a pheochromcytoma was difficult on the basis of these imagings. The final diagnosis was based on a biopsy of the mandible and I-131 Meta-iodobenzylguanidine scintigraphy (MIBG) scintigraphy. A primary lesion of the right adrenal showed low uptake due to wide centric necrosis and metastatic lesions of liver, lumber vertebrae, ribs and sacroiliac joint showed high Uptake on the I-131 MIBG scintigraphy. The final diagnosis as nonfunctioning malignant pheochromocytoma due to the absence of elevation of catecholamine or its metabolite, (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

DOI： 10.1016/S0720-048X(01)00366-7

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：PROFESSOR D A SPANDIDOS  

Thermoradiosensitivity of 8 cell lines of head and neck squamous cell carcinoma (HO-1-u-1, HSC2, HSC3, HSC4, SAS, KB, Hep2, and Ca9-22) was investigated. The differences of radiosensitivity between the cell line with the highest radiosensitivity and the cell line with the lowest radiosensitivity were 1.7-, 7.7-, and 41-fold at 2, 6 and 8 Gy, respectively. The differences between the cell line with the highest thermosensitivity and the cell line with the lowest thermosensitivity were 2.4-, 6.2- and 34.4-fold at 43 degreesC for 40, 60 and 100 min, and 2.6-, 4.9- and 127-fold at 44 degreesC for 20, 30 and 50 min, respectively. These findings indicated that there were large differences in both radiosensitivity and thermosensitivity among the 8 cell lines. There was a negative relationship between radiosensitivity and thermosensitivity (43 degreesC: r=-0.600, 44 degreesC: r=-0.848) in 7 of 8 cell lines, the exception being the HSC4 cell line, which was resistant to both therapies. Four of the 8 cell lines at 43 degreesC and 5 at 44 degreesC in the radiotherapy combined with thermotherapy showed actual survival rates smaller than the theoretical survival rates. Thus, thermoradiotherapy was deemed effective in the head and neck carcinoma cell lines, although 1 of 8 cell lines was resistant to both radiotherapy and thermotherapy.

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCI IRELAND LTD  

it is often difficult to radiographically distingush odontogenic myxomas from ameloblastomas. In the present study, we tried to differentiate odontogenic myxomas from ameloblastomas using dynamic magnetic resonance imaging (dynamic MRI). Two cases of ameloblastoma with cystic companents and two cases of odontogenic myxoma were compared by dynamic MRI. The dynamic MRI features of solid areas of ameloblastomas showed a rapid enhancement, reaching maximum contrast at 45-60 s, and maintained these enhancement levels or showed a gradual wash-out to 600 s thereafter; in contrast, those of the cystic areas of ameloblastomas showed no enhancement. The dynamic MRI features of the whole area of odontogenic myxomas (we considered the whole area to be the tumor substance in the odontogenic myxomas, as based on histopathological examinations) showed a gradual increase in enhancement at 500-600 s. The central portions of the odontogenic myxomas, which did not appear to be enhanced on Gd-T1 weighted images also showed a gradual increase in enhancement at 500-600 s, though the increase was minimal. These results indicate that the dynamic MRI features of odontogenic myxomas are different from those of ameloblastomas. Therefore, dynamic MRI may be a useful tool for diagnosis of myxoma. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

DOI： 10.1016/S0720-048X(01)00453-3

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：PROFESSOR D A SPANDIDOS  

We report on thermochemotherapy in a human salivary gland adenocarcinoma cell line. Hyperthermia reduced the survival rate to 50 and 20% by heating at 43degreesC for 40 and 60 min, respectively, and is by itself useful in human salivary gland carcinoma treatment. Adriamycin, cisplatin, and mitomycin C can possible be used clinically, while bleomycin and 5-fluorouracil cannot, to treat this carcinoma. The optimal temperature was considered to be 41degreesC in adriamycin, 42degreesC in cisplatin, 37degreesC in mitomycin C, and 42degreesC in bleomycin in the thermochemotherapy. Thermochemotherapy is a useful tool in the treatment of human salivary gland carcinoma cells, but it is necessary to select the best anticancer drugs and the optimal temperature for optimal success using this treatment.

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：BLACKWELL MUNKSGAARD  

OBJECTIVE: Odontoma is a comparatively common odontogenic tumor, and it may lead to interference with the eruption of its associated tooth. Odontomas are mostly associated with permanent teeth, and they are rarely associated with deciduous teeth. The purpose of this report is to analyze 107 odontomas and to present a case of complex odontoma associated with a lower deciduous second molar.
SUBJECT AND METHODS: The 106 cases were analyzed with regard to the following parameters: age, gender, location, erupted teeth, congenital missing teeth, radiological features, histopathological features and prognosis.
RESULTS: Of the 106 cases, 41 were complex odontoma, 62 were compound odontoma, and three were immature odontoma. Compound odontoma had a predilection for the anterior. Complex odontoma occurred more often at the mandible.
CONCLUSION: Odontoma located above the tooth crown of lower deciduous molar did not behave clinically different from that associated with permanent tooth. An odontoma could be related with a supernumerary tooth or a missing tooth. If odontomas, which interfered with tooth eruption, were extirpated early, the impacted teeth would probably erupt normally and be normal in shape.

DOI： 10.1034/j.1601-0825.2002.1c778.x

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：PERGAMON-ELSEVIER SCIENCE LTD  

We examined three patients with multiple synchronous Warthin's tumors in the bilateral parotid and described the value of using dynamic MRI. The time course of the contrast index (CI curves) was calculated from a dynamic series. Warthin's tumors showed intermediate signal intensity on T1WI, heterogeneous high and intermediate signal intensity on T2WI and a slight enhancement on Gd-T1WI. Warthin's tumors of CI curves showed specific findings. CI curves in each lesion showed the same pattern. It was difficult to diagnose masses as Warthin's tumors using only MR images on T1, T2 and Gd-T1WI. Dynamic MRI can distinguish Warthin's tumors from other possible tumors except for oncocytoma. Therefore, the use of dynamic MRI is recommended as a diagnostic method for Warthin's tumors in multiple synchronous lesions of the parotid gland. © 2002 Elsevier Science Ltd. All rights reserved.

DOI： 10.1016/S1368-8375(01)00073-2

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCI IRELAND LTD  

We describe the magnetic resonance (MR) features of two cases of nasopalatine duct cyst (NPDC), including the first presentation of TI-weighted images (WI). The signal intensity of the cases of NPDC showed homogeneous high signal intensity on both on T1 and T2WI, although most cysts of maxillofacial regions demonstrate low to intermediate signal intensity on T1WI. NPDC may commonly be of high signal intensity on T1WI, which is consistent with keratin and viscous fluids. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

DOI： 10.1016/S0720-048X(01)00279-0

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCI IRELAND LTD  

The localized form of amyloidosis affecting the head and neck region is rare. The characteristic features of localized amyloidosis appeared as multiple nodules on the tongue, lip, and cheek on computed tomography (CT) and magnetic resonance imaging (MRI). Contrast-enhanced CT scans represented this lesion as a marked nodular enhancement. MR features of this lesion appeared slightly low on T1-weighted images and slightly high on T2-weighted images compared with T1-T2 images of residual normal tongue. Time contrast intensity curves obtained from dynamic MRI rapidly increased to reach a plateau and gradually decreased during the late and delayed phases. MR findings suggest that such lesions might be comprised of fibrous tissue with abundant vessels. This report suggests that dynamic MRI might be helpful for diagnosing localized amyloidosis. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

DOI： 10.1016/S0720-048X(01)00300-X

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：NATURE PUBLISHING GROUP  

Magnetic resonance imaging and computed tomography was performed in one and two patients, respectively, with renal osteodystrophy (ROD). Conventional radiographs clearly depicted the characteristics of ROD of the oral and maxillofacial region. CT and MRI did not add any more information.

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCI IRELAND LTD  

We showed the characteristic features of odontogenic myxoma in the maxillary sinus with computed tomography (CT), magnetic resonance imaging (MRI), and histopathological findings. CT images showed a multilocular soft tissue mass with bone destruction and thinning, and the characteristic finding of this lesion as strands of fine lacelike density. MRI revealed intermediate signal intensity on T1-weighted image and high signal intensity on T2-weighted image. MRI showed the erosive extent of the lesion into the adjacent structures. In contrast T1-weighted image, the peripheral portion of the lesion with a relatively large quantity of collagen bundles was enhanced, while the central portion with only mucoid component was not. The CT and MRI appearances correlated well with the histologic features and therefore were considered to be a useful tool for diagnosis of myxoma. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

DOI： 10.1016/S0720-048X(00)00229-1

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/BF02489722

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：NATURE PUBLISHING GROUP  

We report two cases of polyostotic eosinophilic granuloma (EG). Both plain radiographs and CT showed diffuse osteolytic lesions which suggested malignant tumors. Although EG was polyostotic, the prognosis was relatively good. Both cases developed new lesions over a followup period of 4-5 years and therefore further long-term review is needed.

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：NATURE PUBLISHING GROUP  

The glandular odontogenic cyst (GOC) is a rare odontogenic cyst. There has only been one reported case of the simultaneous presence of GOC and ameloblastoma. The radiographic features of GOC are well established but the MR findings have not been described. We report a case of GOC associated with ameloblastoma with special reference to the correlation of the diagnostic imaging with the histopathological features.

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健常ボランティア17名を対象に顎顔面領域の主要動脈の描出を試みた.舌動脈,顔面動脈に関しては撮像条件をTR/FA=35〜45/15〜20の範囲に設定することで,良好な画像が得られた.下歯槽動脈の描出は種々撮像条件を変えたが描出困難であった.TRを固定しFAを大きくした場合,各血管とも末梢における血管描出能は不良になり,血管周囲組織からの信号強度は減少した.FAを固定しTRを長くした場合,25〜45msの範囲内では末梢における血管描出能は向上したが,TR=50msでは末梢部のコントラストは低下した.血管周囲組織からの信号強度はTRの増大に伴い増強した

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Language：Japanese   Publisher：(一社)日本癌治療学会  

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Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)   Publisher：(NPO)日本口腔科学会  

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Language：Japanese   Publisher：(一社)日本口腔内科学会  

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Language：Japanese   Publisher：日本再生歯科医学会  

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Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)   Publisher：(NPO)日本口腔科学会  

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Language：Japanese   Publishing type：Research paper, summary (national, other academic conference)   Publisher：(NPO)日本口腔科学会  

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Language：Japanese   Publisher：日本画像医学会  

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Language：Japanese   Publisher：(NPO)日本歯科放射線学会  

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Language：English   Publisher：PERGAMON-ELSEVIER SCIENCE LTD  

We investigated the relationship between the enhanced patterns acquired by dynamic MRI and the tumor cell proliferation estimated by immunostaining proliferating cell nuclear antigen (PCNA) in oral squamous cell carcinoma (SCC). Thirty patients with primary oral SCC underwent dynamic contrast enhanced (DCE)-MRI using a three-dimensional fast imaging with steady-state precession sequence. Tumor cell proliferation of all surgical specimens was evaluated using immunohistochernical staining with the anti-PCNA antibody. The relationship between the dynamic MR1 parameters (maximum CI and maximum CI gain) and the PCNA labeling index was statistically analyzed using regression analysis. The time contrast index curves of all cases showed a rapid and high uptake pattern. The PCNA labeling index showed a significant correlation with tnaxitnutn CI and maximum CI gain (P&lt;0.0001, r=0.866 and P=0.0019, r=0.544, respectively). The assessment of DCE-MRI parameters may provide valuable information for tumor cell proliferation of the patients with oral cancer. (C) 2003 Elsevier Science Ltd. All rights reserved.

DOI： 10.1016/S1368-8375(02)00119-7

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Event date： 2023.4.13 - 2023.4.15

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Event date： 2023.1.26 - 2023.2.28

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Event date： 2022.11.26

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Event date： 2020.12.5

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Venue：北九州（オンライン学会）  

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Event date： 2020.10.31 - 2020.11.1

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Event date： 2019.12.7

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Venue：北九州市  

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Event date： 2019.8.22 - 2019.8.25

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Venue：Philadelphia, USA  

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Event date： 2019.6.14 - 2019.6.16

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Venue：日本大学歯学部付属歯科病院 7階創設百周年記念講堂  

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Event date： 2019.3.8 - 2019.3.9

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Venue：ステーションコンファレンス東京  

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Venue：日本大学歯学部  

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Venue：横浜市開港記念会館  

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Event date： 2017.11.10 - 2017.11.11

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Venue：盛岡  

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Event date： 2017.9.8 - 2017.9.9

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Venue：札幌市  

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Event date： 2017.9.8 - 2017.9.9

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Venue：札幌市  

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Event date： 2017.9.8 - 2017.9.9

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Venue：札幌市  

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Venue：札幌市  

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Event date： 2017.6.2 - 2017.6.4

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Event date： 2017.4.26 - 2017.4.29

Language：English   Presentation type：Oral presentation (general)  

Venue：Kaohsiung, Taiwan  

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Event date： 2017.4.26 - 2017.4.29

Language：English   Presentation type：Poster presentation  

Venue：Kaohsiung, Taiwan  

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Event date： 2016.11.10 - 2016.11.12

Language：English   Presentation type：Poster presentation  

Venue：Chiangmai, Thailand  

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Event date： 2016.11.10 - 2016.11.12

Language：English   Presentation type：Poster presentation  

Venue：Chiangmai, Thailand  

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Event date： 2016.11.10 - 2016.11.12

Language：English   Presentation type：Poster presentation  

Venue：Chiangmai, Thailand  

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Event date： 2016.11.6

Language：Japanese   Presentation type：Poster presentation  

Venue：ステーションコンファレンス東京  

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Event date： 2016.10.29 - 2016.10.30

Presentation type：Oral presentation (general)  

Venue：東京医科歯科大学大学院歯学研究院（学術総合センター）  

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Event date： 2016.10.29 - 2016.10.30

Presentation type：Oral presentation (general)  

Venue：東京医科歯科大学大学院歯学研究院（学術総合センター）  

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Event date： 2016.10.22

Language：Japanese   Presentation type：Oral presentation (general)  

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Event date： 2016.7.1 - 2016.7.2

Presentation type：Poster presentation  

Venue：大阪府吹田市  

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Event date： 2016.6.17 - 2016.6.19

Language：Japanese   Presentation type：Poster presentation  

Venue：大阪市、グランキューブ大阪  

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Event date： 2016.3.18

Language：Japanese   Presentation type：Poster presentation  

Venue：テクノサポート岡山  

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Event date： 2015.12.12

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：中之島センター  

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Event date： 2015.12.4

Language：Japanese   Presentation type：Poster presentation  

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Event date： 2015.10.23 - 2015.10.25

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：九州大学  

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Event date： 2015.10.23 - 2015.10.25

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：九州大学  

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Event date： 2015.9.5

Language：Japanese   Presentation type：Poster presentation  

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Event date： 2015.9.5

Language：Japanese   Presentation type：Poster presentation  

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Event date： 2015.7.18

Language：Japanese   Presentation type：Oral presentation (general)  

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Event date： 2015.7.10 - 2015.7.11

Language：Japanese   Presentation type：Poster presentation  

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Event date： 2015.6.28

Language：Japanese   Presentation type：Poster presentation  

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Event date： 2015.6.6 - 2015.6.7

Language：Japanese   Presentation type：Oral presentation (general)  

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Event date： 2015.6.6 - 2015.6.7

Language：Japanese   Presentation type：Oral presentation (general)  

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Event date： 2015.5.13 - 2015.5.15

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：大阪国際会議場  

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Event date： 2014.12.6

Language：Japanese   Presentation type：Oral presentation (general)  

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Event date： 2014.11.20 - 2014.11.22

Language：English   Presentation type：Poster presentation  

Venue：Bali、 Indonesia  

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Event date： 2014.11.1 - 2014.11.2

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：岡山Jホール  

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Event date： 2014.10.26

Presentation type：Oral presentation (general)  

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Event date： 2014.9.18 - 2014.9.20

Language：Japanese   Presentation type：Poster presentation  

Venue：九州大学  

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Event date： 2014.9.18 - 2014.9.20

Language：Japanese   Presentation type：Poster presentation  

Venue：九州大学  

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Event date： 2014.7.4 - 2014.7.5

Language：Japanese   Presentation type：Poster presentation  

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Event date： 2014.6.6 - 2014.6.8

Language：Japanese   Presentation type：Poster presentation  

Venue：東京（タワーホール船堀）  

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Event date： 2014.6.6 - 2014.6.8

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：東京（タワーホール船堀）  

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Event date： 2014.5.7 - 2014.5.9

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：東京（京王プラザホテル）  

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Event date： 2013.11.26

Language：English   Presentation type：Oral presentation (invited, special)  

Venue：Rio de Janeiro, Brazil  

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Event date： 2013.11.16

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：岡山市  

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Event date： 2013.9.13 - 2013.9.14

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：東京都千代田区  

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Event date： 2013.9.13 - 2013.9.14

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：東京都千代田区  

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Event date： 2013.8.22

Language：Japanese   Presentation type：Poster presentation  

Venue：神奈川県横浜市  

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Event date： 2013.6.22 - 2013.6.27

Language：English   Presentation type：Poster presentation  

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Event date： 2013.6.22 - 2013.6.27

Language：English   Presentation type：Poster presentation  

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Event date： 2013.5.31 - 2013.6.2

Language：Japanese   Presentation type：Poster presentation  

Venue：福岡市  

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Event date： 2013.5.31 - 2013.6.2

Language：Japanese   Presentation type：Poster presentation  

Venue：福岡市  

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Event date： 2013.5.22 - 2013.5.24

Language：Japanese   Presentation type：Poster presentation  

Venue：宇都宮市  

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Event date： 2013.5.22 - 2013.5.24

Language：Japanese   Presentation type：Poster presentation  

Venue：宇都宮市  

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Event date： 2012.12.8

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：福岡市  

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Event date： 2012.11.25

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：岡山  

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Event date： 2012.10.26 - 2012.10.27

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：大阪市  

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Event date： 2012.10.26 - 2012.10.27

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：大阪市  

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Event date： 2012.9.21 - 2012.9.22

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：千代田区  

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Event date： 2012.9.21 - 2012.9.22

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：千代田区  

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Event date： 2012.9.14 - 2012.9.16

Language：English   Presentation type：Poster presentation  

Venue：Xi'an、中国  

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Event date： 2012.9.1 - 2012.9.2

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：神戸市  

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Event date： 2012.6.20 - 2012.6.23

Language：English   Presentation type：Poster presentation  

Venue：Igua?u Falls、ブラジル  

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Event date： 2012.6.1 - 2012.6.3

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：盛岡市  

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Event date： 2012.6.1 - 2012.6.3

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：盛岡市  

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Event date： 2012.5.17 - 2012.5.18

Language：Japanese   Presentation type：Poster presentation  

Venue：広島市  

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Event date： 2012.5.17 - 2012.5.18

Language：Japanese   Presentation type：Poster presentation  

Venue：広島市  

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Event date： 2011.12.10

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：名古屋  

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Event date： 2011.11.26

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：松山市  

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Event date： 2011.11.26

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：松山市  

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Event date： 2011.11.13

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：岡山  

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Event date： 2011.9.30 - 2011.10.2

Presentation type：Oral presentation (general)  

Venue：新潟  

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Event date： 2011.5.26 - 2011.5.29

Language：English   Presentation type：Poster presentation  

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Event date： 2011.5.26 - 2011.5.29

Language：English   Presentation type：Poster presentation  

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Event date： 2011.5.26 - 2011.5.29

Language：English   Presentation type：Poster presentation  

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Event date： 2011.5.22

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：東京  

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Event date： 2011.5.22

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：東京  

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Event date： 2011.4.21 - 2011.4.22

Language：Japanese   Presentation type：Poster presentation  

Venue：東京  

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Event date： 2011.2.18 - 2011.2.19

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：東京  

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Event date： 2010.12.11

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：北九州市  

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Event date： 2010.11.14 - 2010.11.16

Language：English   Presentation type：Oral presentation (general)  

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Event date： 2010.11.6

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：広島市  

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Event date： 2010.11.6

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：広島市  

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Event date： 2010.9.3 - 2010.9.5

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：鹿児島  

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Event date： 2010.6.23 - 2010.6.24

Language：Japanese   Presentation type：Poster presentation  

Venue：札幌市  

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Event date： 2010.6.2 - 2010.6.5

Language：English   Presentation type：Poster presentation  

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Event date： 2010.5.29 - 2010.5.30

Presentation type：Oral presentation (general)  

Venue：千葉県松戸市  

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Event date： 2010.5.29 - 2010.5.30

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：千葉県松戸市  

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Event date： 2010.4.23 - 2010.4.25

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：横浜市  

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Event date： 2010.4.23 - 2010.4.25

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：横浜市  

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Event date： 2009.11.28

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：岡山市  

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Event date： 2009.11.14

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：倉敷市  

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Event date： 2009.10.24 - 2009.10.25

Presentation type：Oral presentation (general)  

Venue：札幌市  

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Event date： 2009.6.28 - 2009.7.2

Language：English   Presentation type：Poster presentation  

Venue：Amsterdam, The Netherlands  

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Event date： 2009.6.28 - 2009.7.2

Language：English   Presentation type：Poster presentation  

Venue：Amsterdam, The Netherlands  

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Event date： 2009.5.28 - 2009.5.30

Presentation type：Poster presentation  

Venue：大阪市  

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Event date： 2009.5.28 - 2009.5.30

Presentation type：Poster presentation  

Venue：大阪市  

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Event date： 2009.5.28 - 2009.5.30

Presentation type：Poster presentation  

Venue：大阪市  

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