Updated on 2025/06/07

写真a

 
TAKEUCHI Sakae
 
Organization
Faculty of Environmental, Life, Natural Science and Technology Professor
Position
Professor
External link

Degree

  • (BLANK)

Research Interests

  • feather pigmentation

  • chicken

  • melanocortin system

  • sexual dimorphism

  • feather development

Research Areas

  • Life Science / Molecular biology

  • Life Science / Animal physiological chemistry, physiology and behavioral biology

  • Life Science / Morphology and anatomical structure

Education

  • Tohoku University   大学院理学研究科博士後期課程   生物学専攻

    1987.4 - 1990.3

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    Country: Japan

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  • Tohoku University   大学院理学研究科博士前期課程   生物学専攻

    1985.4 - 1987.3

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  • Tohoku University   理学部   生物学科

    1981.4 - 1985.3

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    Country: Japan

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Research History

  • 岡山大学教育推進機構 入試・高大接続部門 副部門長

    2025.4

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  • 岡山大学学術研究院環境生命自然科学学域(理)   教授

    2023.4

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  • 岡山大学大学院環境生命自然科学研究科 副研究科長(教育担当)

    2023.4 - 2025.3

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  • 岡山大学大学院自然科学研究科 副研究科長(教育担当)

    2021.4 - 2023.3

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  • Okayama University   The Graduate School of Natural Science and Technology   Professor

    2014.4 - 2023.3

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Professional Memberships

 

Papers

  • Identification of pennaceous barbule cell factor (PBCF), a novel gene with spatiotemporal expression in barbule cells during feather development Reviewed International journal

    Minori Nakaoka, Hibiki Fukuchi, Maho Ogoshi, Sayaka Aizawa, Sakae Takeuchi

    Gene   941   149244 - 149244   2025.3

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    Authorship:Last author, Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.gene.2025.149244

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  • Crosstalk between prolactin, insulin-like growth factors, and thyroid hormones in feather growth regulation in neonatal chick wings, Reviewed International journal

    Yuri Nozawa, Ayako Okamura, Hibiki Fukuchi, Masamichi Shinohara, Sayaka Aizawa, Sakae Takeuchi

    General and Comparative Endocrinology, 2024, 114657, ISSN 0016-6480   2024.12

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ygcen.2024.114657

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  • Revisiting the hormonal control of sexual dimorphism in chicken feathers Reviewed International journal

    Li You, Kaori Nishio, Kinue Kowata, Minaru Horikawa, Hibiki Fukuchi, Maho Ogoshi, Sayaka Aizawa, Sakae Takeuchi

    General and Comparative Endocrinology   357   114601 - 114601   2024.10

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    DOI: 10.1016/j.ygcen.2024.114601

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  • A regulatory mechanism of mouse kallikrein 1 gene expression by estrogen Reviewed International journal

    Takumi Iwasaki, Megumi Tokumori, Misaki Matsubara, Fumiya Ojima, Kana Kamigochi, Sayaka Aizawa, Maho Ogoshi, Atsushi P. Kimura, Sakae Takeuchi, Sumio Takahashi

    Molecular and Cellular Endocrinology   577   112044 - 112044   2023.11

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.mce.2023.112044

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  • Neuromedin U-deficient rats do not lose body weight or food intake Reviewed International journal

    Kyoka Yokogi, Yuki Goto, Mai Otsuka, Fumiya Ojima, Tomoe Kobayashi, Yukina Tsuchiba, Yu Takeuchi, Masumi Namba, Mayumi Kohno, Minami Tetsuka, Sakae Takeuchi, Makoto Matsuyama, Sayaka Aizawa

    Scientific Reports   12 ( 1 )   17472 - 17472   2022.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    Studies in genetically modified mice establish that essential roles of endogenous neuromedin U (NMU) are anorexigenic function and metabolic regulation, indicating that NMU is expected to be a potential target for anti-obesity agents. However, in central administration experiments in rats, inconsistent results have been obtained, and the essential role of NMU energy metabolism in rats remain unclear. This study aims to elucidate the role of endogenous NMU in rats. We generated NMU knockout (KO) rats that unexpectedly showed no difference in body weight, adiposity, circulating metabolic markers, body temperature, locomotor activity, and food consumption in both normal and high fat chow feeding. Furthermore, unlike reported in mice, expressions of Nmu and NMU receptor type 2 (Nmur2) mRNA were hardly detectable in the rat hypothalamic nuclei regulating feeding and energy metabolism, including the arcuate nucleus and paraventricular nucleus, while Nmu was expressed in pars tuberalis and Nmur2 was expressed in the ependymal cell layer of the third ventricle. These results indicate that the species–specific expression pattern of Nmu and Nmur2 may allow NMU to have distinct functions across species, and that endogenous NMU does not function as an anorexigenic hormone in rats.

    DOI: 10.1038/s41598-022-21764-6

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    Other Link: https://www.nature.com/articles/s41598-022-21764-6

  • Adrenomedullin 2 and 5 activate the calcitonin receptor-like receptor (clr) – Receptor activity-modifying protein 3 (ramp3) receptor complex in Xenopus tropicalis Reviewed International journal

    Maho Ogoshi, Mikoto Takahashi, Kota Aoyagi, Kazuyoshi Ukena, Sayaka Aizawa, Hideaki Takeuchi, Sumio Takahashi, Sakae Takeuchi

    General and Comparative Endocrinology   306   113752 - 113752   2021.5

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    Authorship:Last author   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.ygcen.2021.113752

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  • Discovery of a new nucleotide substitution in the MC1R gene and haplotype distribution in native and non-Japanese chicken breeds Reviewed

    M. H. Kabir, A. Takenouchi, M. I. Haqani, Y. Nakamura, S. Takeuchi, M. Tsudzuki

    Animal Genetics   51 ( 2 )   235 - 248   2020.3

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/age.12906

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  • Adenosine stimulates neuromedin U mRNA expression in the rat pars tuberalis Reviewed

    Sayaka Aizawa, Tingting Gu, A. Kaminoda, R. Fujioka, Fumiya Ojima, Ichiro Sakata, Takafumi Sakai, Maho Ogoshi, S. Takahashi, S. Takeuchi

    Molecular and Cellular Endocrinology   1 ( 496 )   2019.10

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    Authorship:Last author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.mce.2019.110518

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  • Runx3 regulates folliculogenesis and steroidogenesis in granulosa cells of immature mice Reviewed

    Fumiya Ojima, Yuka Saito, Yukiko Tsuchiya, Maho Ogoshi, Hiroshi Fukamachi, Kenichi Inagaki, Fumio Otsuka, Sakae Takeuchi, Sumio Takahashi

    Cell and Tissue Research   375 ( 3 )   743 - 754   2019.3

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00441-018-2947-2

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  • Changes in prolactin receptor homodimer availability may cause late feathering in chickens Reviewed

    Ayako Okamura, Ayane Masumoto, Atsushi Takenouchi, Toshiyuki Kudo, Sayaka Aizawa, Maho Ogoshi, Sumio Takahashi, Masaoki Tsudzuki, Sakae Takeuchi

    General and Comparative Endocrinology   272   109 - 116   2019.2

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    Authorship:Last author, Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.ygcen.2018.12.011

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  • Runx3 transcription factor regulates ovarian functions and ovulation in female mice Reviewed

    Fumiya Ojima, Yuka Saito, Yukiko Tsuchiya, Daichi Kayo, Syusuke Taniuchi, Maho Ogoshi, Hiroshi Fukamachi, Sakae Takeuchi, Sumio Takahashi

    JOURNAL OF REPRODUCTION AND DEVELOPMENT   62 ( 5 )   479 - 486   2016.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1262/jrd.2016-005

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  • Functional characterization of the mouse melanocortin 3 receptor gene promoter. Reviewed International journal

    Keisuke Okutsu, Fumiya Ojima, Naoto Shinohara, Shusuke Taniuchi, Yasusyo Mizote, Kenji Aoki, Toshiyuki Kudo, Maho Ogoshi, Sakae Takeuchi, Sumio Takahashi

    Gene   562 ( 1 )   62 - 69   2015.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.gene.2015.02.043

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  • IGF-1 Gene Expression Is Differentially Regulated by Estrogen Receptors alpha and beta in Mouse Endometrial Stromal Cells and Ovarian Granulosa Cells Reviewed

    Yuki Ogo, Shusuke Taniuchi, Fumiya Ojima, Sayo Hayashi, Itsuo Murakami, Yuka Saito, Sakae Takeuchi, Toshiyuki Kudo, Sumio Takahashi

    JOURNAL OF REPRODUCTION AND DEVELOPMENT   60 ( 3 )   216 - 223   2014.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1262/jrd.2013-085

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  • Identification of a feather beta-keratin gene exclusively expressed in pennaceous barbule cells of contour feathers in chicken Reviewed

    Kinue Kowata, Minori Nakaoka, Kaori Nishio, Ayaka Fukao, Akira Satoh, Maho Ogoshi, Sumio Takahashi, Masaoki Tsudzuki, Sakae Takeuchi

    GENE   542 ( 1 )   23 - 28   2014.5

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.gene.2014.03.027

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  • Insulin-like growth factor 1 mRNA expression in the uterus of streptozotocin-treated diabetic mice Reviewed

    Yoshie Manabe, Makoto Tochigi, Akiyoshi Moriwaki, Sakae Takeuchi, Sumio Takahashi

    Journal of Reproduction and Development   59 ( 4 )   398 - 404   2013

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1262/jrd.2012-169

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  • Conserved distal promoter of the agouti signaling protein (ASIP) gene controls sexual dichromatism in chickens Reviewed

    Eri Oribe, Ayaka Fukao, Chihiro Yoshihara, Misa Mendori, Karen G. Rosal, Sumio Takahashi, Sakae Takeuchi

    GENERAL AND COMPARATIVE ENDOCRINOLOGY   177 ( 2 )   231 - 237   2012.6

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    DOI: 10.1016/j.ygcen.2012.04.016

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  • Elaborate color patterns of individual chicken feathers may be formed by the agouti signaling protein Reviewed International journal

    Chihiro Yoshihara, Ayaka Fukao, Keita Ando, Yuichi Tashiro, Shusuke Taniuchi, Sumio Takahashi, Sakae Takeuchi

    GENERAL AND COMPARATIVE ENDOCRINOLOGY   175 ( 3 )   495 - 499   2012.2

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ygcen.2011.12.009

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  • Pit-1w may regulate prolactin gene expression in mouse testis Reviewed

    Kazuki Maeda, Shusuke Taniuchi, Sumio Takahashi, Sakae Takeuchi

    General and Comparative Endocrinology   175 ( 00 )   180 - 184   2012

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    DOI: 10.1016/j.ygcen.2012.05.004

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  • Transforming growth factor-α mRNA expression and its possible roles in mouse endometrial stromal cells Reviewed

    Tetsuya Maekawa, Atsuko Sakuma, Shusuke Taniuchi, Yuki Ogo, Taisen Iguchi, Sakae Takeuchi, Sumio Takahashi

    Zoological Science   29 ( 6 )   377 - 383   2012

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.2108/zsj.29.377

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  • Runx3 expression and its roles in mouse endometrial cells. Reviewed

    Tsuchiya Y, Saito Y, Taniuchi S, Sakuma A, Maekawa T, Fukamachi H, Takeuchi S, Takahashi S

    The Journal of reproduction and development   58 ( 5 )   592 - 598   2012

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    DOI: 10.1262/jrd.2012-066

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  • A Novel Deletion Mutation of Mouse Ruby-eye 2 Named ru2(d)/Hps5(ru2-d) Inhibits Melanocyte Differentiation and Its Impaired Differentiation is Rescued by L-tyrosine Reviewed

    Tomohisa Hirobe, Chihiro Yoshihara, Sakae Takeuchi, Kazumasa Wakamatsu, Shosuke Ito, Hiroyuki Abe, Yoko Kawa, Yoshinao Soma

    ZOOLOGICAL SCIENCE   28 ( 11 )   790 - 801   2011.11

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    DOI: 10.2108/zsj.28.790

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  • Identification of mammalian Pit-1w, possibly involved in spermatogenesis in mice Reviewed

    Shusuke Taniuchi, Kazuki Maeda, Toshiyuki Kudo, Sumio Takahashi, Sakae Takeuchi

    GENERAL AND COMPARATIVE ENDOCRINOLOGY   173 ( 2 )   289 - 294   2011.9

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    DOI: 10.1016/j.ygcen.2011.06.016

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  • Role of chicken Pit-1 isoforms in activating growth hormone gene Reviewed

    Daisuke Murase, Shusuke Taniuchi, Sakae Takeuchi, Hiromi Adachi, Norio Kansaku, Katsuichiro Okazaki, Takeshi Ohkubo

    GENERAL AND COMPARATIVE ENDOCRINOLOGY   173 ( 2 )   248 - 252   2011.9

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    DOI: 10.1016/j.ygcen.2011.06.007

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  • Feather follicles express two classes of pro-opiomelanocortin (POMC) mRNA using alternative promoters in chickens Reviewed International journal

    Chihiro Yoshihara, Yuichi Tashiro, Shusuke Taniuchi, Harumi Katayama, Sumio Takahashi, Sakae Takeuchi

    GENERAL AND COMPARATIVE ENDOCRINOLOGY   171 ( 1 )   46 - 51   2011.3

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    DOI: 10.1016/j.ygcen.2010.12.018

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  • Isolation and characterisation of prolactin-releasing peptide in chicks and its effect on prolactin release and feeding behaviour Reviewed

    T. Tachibana, S. Moriyama, A. Takahashi, A. Tsukada, A. Oda, S. Takeuchi, T. Sakamoto

    Journal of Neuroendocrinology   23 ( 1 )   74 - 81   2011.1

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    DOI: 10.1111/j.1365-2826.2010.02078.x

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  • Local agouti signaling protein/melanocortin signaling system that possibly regulates lipid metabolism in adipose tissues of chickens Reviewed

    Masafumi Yabuuchi, Kana Bando, Misato Hiramatsu, Sumio Takahashi, Sakae Takeuchi

    Journal of Poultry Science   47 ( 2 )   176 - 182   2010

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    DOI: 10.2141/jpsa.009110

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  • 鳥類におけるメラニンを用いた体色発現システムの分子機構 Reviewed

    織部恵莉, 吉原千尋, 高橋純夫, 竹内 栄

    比較生理生化学   26 ( 1 )   3 - 11   2009

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    DOI: 10.3330/hikakuseiriseika.26.3

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  • Estradiol, progesterone, and transforming growth factor α regulate insulin-like growth factor binding protein-3 (IGFBP3) expression in mouse endometrial cells Reviewed

    Tetsuya Maekawa, Sakae Takeuchi, Munetoshi Kanayama, Sumio Takahashi

    Zoological Science   26 ( 2 )   131 - 138   2009

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.2108/zsj.26.131

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  • Loss of Runx3 affects ovulation and estrogen-induced endometrial cell proliferation in female mice Reviewed

    Atsuko Sakuma, Hiroshi Fukamachi, Kosei Ito, Yoshiaki Ito, Sakae Takeuchi, Sumio Takahashi, Sumio Takahashi

    Molecular Reproduction and Development   75 ( 11 )   1653 - 1661   2008.11

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    DOI: 10.1002/mrd.20904

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  • Identification of unique thyrotropin receptor (TSHR) splice variants in the chicken: The chicken TSHR gene revisited Reviewed

    Sylvia V.H. Grommen, Shusuke Taniuchi, Veerle M. Darras, Sumio Takahashi, Sakae Takeuchi, Bert De Groef

    General and Comparative Endocrinology   156 ( 3 )   460 - 463   2008

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ygcen.2008.03.003

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  • Alternative leader-exon usage in mouse IGF-I mRNA variants: Class 1 and class 2 IGF-I mRNAs Reviewed

    Takashj Ohtsuki, Mariko Otsuki, Yousuke Murakami, Kensaku Hirata, Sakae Takeuchi, Sumio Takahashi

    Zoological Science   24 ( 3 )   241 - 247   2007

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.2108/zsj.24.241

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  • Expression of interleukin-18 receptor mRNA in the mouse endometrium Reviewed

    Mariko Otsuki, Kenji Kusumoto, Yousuke Murakami, Munetoshi Kanayama, Sakae Takeuchi, Sumio Takahashi

    Journal of Reproduction and Development   53 ( 1 )   59 - 68   2007

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1262/jrd.18036

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  • Corticotropin-releasing hormone or dexamethasone regulates rat proopiomelanocortin transcription through Tpit/Pitx-responsive element in its promoter Reviewed

    Itsuo Murakami, Sakae Takeuchi, Toshiyuki Kudo, Shizuyo Sutou, Sumio Takahashi

    Journal of Endocrinology   193 ( 2 )   279 - 290   2007

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1677/JOE-06-0143

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  • Molecular cloning, tissue distribution, and ontogenic thyroidal expression of the chicken thyrotropin receptor Reviewed

    Sylvia V.H. Grommen, Shusuke Taniuchi, Tom Janssen, Liliane Schoofs, Sumio Takahashi, Sakae Takeuchi, Veerle M. Darras, Bert De Groef

    Endocrinology   147 ( 8 )   3943 - 3951   2006

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/en.2005-1223

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  • A possible involvement of ASIP in the regulation of feather pigmentation in birds Reviewed

    Yuichi Tashiro, Chihiro Yoshihara, Sakae Takeuchi

    Journal of the Yamashina Institute for Ornithology   38 ( 1 )   40 - 46   2006

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    DOI: 10.3312/jyio.38.40

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  • Recent developments in our understanding of the avian melanocortin system: Its involvement in the regulation of pigmentation and energy homeostasis Invited Reviewed International journal

    T Boswell, S Takeuchi

    PEPTIDES   26 ( 10 )   1733 - 1743   2005.10

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    DOI: 10.1016/j.peptides.2004.11.039

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  • Insulin-like growth factor-I stimulated DNA replication in mouse endometrial stromal cells Reviewed

    A Inoue, S Takeuchi, S Takahashi

    JOURNAL OF REPRODUCTION AND DEVELOPMENT   51 ( 3 )   305 - 313   2005.6

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    DOI: 10.1262/jrd.16076

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  • Organ-specific and age-dependent expression of insulin-like growth factor-I (IGF-I) mRNA variants: IGF-IA and IB mRNAs in the mouse Reviewed

    Takashi Ohtsuki, Mariko Otsuki, Yousuke Murakami, Tetsuya Maekawa, Takashi Yamamoto, Koji Akasaka, Sakae Takeuchi, Sumio Takahashi

    Zoological Science   22 ( 9 )   1011 - 1021   2005

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    DOI: 10.2108/zsj.22.1011

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  • Interleukin-18 (IL-18) mRNA expression and localization of IL-18 mRNA-expressing cells in the mouse uterus Reviewed

    Kenji Kusumoto, Yousuke Murakami, Mariko Otsuki, Munetoshi Kanayama, Sakae Takeuchi, Sumio Takahashi

    Zoological Science   22 ( 9 )   1003 - 1010   2005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.2108/zsj.22.1003

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  • Estrogen inhibits interleukin-18 mRNA expression in the mouse uterus Reviewed

    Yousuke Murakami, Mariko Otsuki, Kenji Kusumoto, Sakae Takeuchi, Sumio Takahashi

    Journal of Reproduction and Development   51 ( 5 )   639 - 647   2005

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1262/jrd.17029

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  • Transforming growth factor-α stimulates proliferation of mammotrophs and corticotrophs in the mouse pituitary Reviewed

    Oomizu, S, Honda, J, Takeuchi, S, Kakeya, T, Masui, Takahashi, S

    Journal of Endocrinology   165   493 - 501   2005

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  • The melanocortin receptor-1 gene but not the proopiomelanocortin gene is expressed in melanoblasts and contributes their differentiation in the mouse skin. Reviewed International journal

    Tomohisa Hirobe, Sakae Takeuchi, Eri Hotta

    Pigment cell research   17 ( 6 )   627 - 35   2004.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1600-0749.2004.00179.x

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  • The melanocortin receptor subtypes in chicken have high preference to ACTH-derived peptides. Reviewed International journal

    Maria K Ling, Eri Hotta, Zuzana Kilianova, Tatjana Haitina, Aneta Ringholm, Lisa Johansson, Nicole Gallo-Payet, Sakae Takeuchi, Helgi B Schiöth

    British journal of pharmacology   143 ( 5 )   626 - 37   2004.11

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    DOI: 10.1038/sj.bjp.0705900

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  • Pheomelanin production in the epidermis from newborn agouti mice is induced by the expression of the agouti gene in the dermis Reviewed

    T Hirobe, S Takeuchi, E Hotta, K Wakamatsu, S Ito

    PIGMENT CELL RESEARCH   17 ( 5 )   506 - 514   2004.10

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    DOI: 10.1111/j.1600-0749.2004.00176.x

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  • Effect of estrogen on melanocortin-3 receptor mRNA expression in mouse pituitary glands in vivo and in vitro. Reviewed International journal

    Ryusei Matsumura, Sakae Takeuchi, Sumio Takahashi

    Neuroendocrinology   80 ( 3 )   143 - 51   2004

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000082355

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  • alpha-melanocyte-stimulating hormone stimulates prolactin secretion through melanocortin-3 receptors expressed in mammotropes in the mouse pituitary Reviewed International journal

    R Matsumura, C Takagi, T Kakeya, K Okuda, S Takeuchi, S Takahashi

    NEUROENDOCRINOLOGY   78 ( 2 )   96 - 104   2003.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000071965

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  • IGF-I regulates pro-opiomelanocortin and GH gene expression in the mouse pituitary gland Reviewed

    J Honda, Y Manabe, R Matsumura, S Takeuchi, S Takahashi

    JOURNAL OF ENDOCRINOLOGY   178 ( 1 )   71 - 82   2003.7

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    DOI: 10.1677/joe.0.1780071

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  • Remarkable synteny conservation of melanocortin receptors in chicken, human, and other vertebrates Reviewed International journal

    HB Schioth, T Raudsepp, A Ringholm, R Fredriksson, S Takeuchi, D Larhammar, BP Chowdhary

    GENOMICS   81 ( 5 )   504 - 509   2003.5

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    DOI: 10.1016/S0888-7543(03)00028-4

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  • Epidermal growth factor and transforming growth factor-alpha stimulate the proliferation of mouse uterine stromal cells Reviewed

    N Komatsu, T Maekawa, S Takeuchi, S Takahashi

    ZOOLOGICAL SCIENCE   20 ( 5 )   639 - 645   2003.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2108/zsj.20.639

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  • Association of feather colour with constitutively active melanocortin 1 receptors in chicken Reviewed International journal

    MK Ling, MC Lagerstrom, R Fredriksson, R Okimoto, NI Mundy, S Takeuchi, HB Schioth

    EUROPEAN JOURNAL OF BIOCHEMISTRY   270 ( 7 )   1441 - 1449   2003.4

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    DOI: 10.1046/j.1432-1033.2003.03506.x

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  • Gene expression and the physiological role of transforming growth factor-alpha in the mouse pituitary Reviewed

    S Sharma, S Oomizu, T Kakeya, T Masui, S Takeuchi, S Takahashi

    ZOOLOGICAL SCIENCE   20 ( 1 )   83 - 89   2003.1

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  • Fasting differentially regulates expression of agouti-related peptide, pro-opiomelanocortin, prepro-orexin, and vasoactive intestinal polypeptide mRNAs in the hypothalamus of Japanese quail Reviewed

    D Phillips-Singh, Q Li, S Takeuchi, T Ohkubo, PJ Sharp, T Boswell

    CELL AND TISSUE RESEARCH   313 ( 2 )   217 - 225   2003

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    DOI: 10.1007/s00441-003-0755-8

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  • Avian melanocortin system: alpha-MSH may act as an autocrine/paracrine hormone - A minireview Invited Reviewed International journal

    S Takeuchi, S Takahashi, R Okimoto, HB Schioth, T Boswell

    MELANOCORTIN SYSTEM   994   366 - 372   2003

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    DOI: 10.1111/j.1749-6632.2003.tb03201.x

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  • Induction of mammotroph development by a combination of epidermal growth factor, insulin, and estradiol-17 beta in rat pituitary tumor GH3 cells Reviewed

    T Kakeya, S Takeuchi, S Takahashi

    ZOOLOGICAL SCIENCE   19 ( 7 )   789 - 795   2002.7

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    DOI: 10.2108/zsj.19.789

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  • Neurons expressing neuropeptide Y mRNA in the infundibular hypothalamus of Japanese quail are activated by fasting and co-express agouti-related protein mRNA Reviewed

    T Boswell, QS Li, S Takeuchi

    MOLECULAR BRAIN RESEARCH   100 ( 1-2 )   31 - 42   2002.4

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    DOI: 10.1016/S0169-328X(02)00145-6

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  • Hepatocyte growth factor is a regulator in the proliferation of microvascular endothelial cells in bovine corpus luteum Reviewed

    C Fujiwara, S Murakami, H Taniguchi, Y Miyamoto, R Sakumoto, S Takeuchi, S Takahashi, K Okuda

    JOURNAL OF REPRODUCTION AND DEVELOPMENT   48 ( 1 )   49 - 55   2002.2

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    DOI: 10.1262/jrd.48.49

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  • Intrapituitary regulatory system of mammotrophs in the mouse Reviewed

    Sumio Takahashi, S. Sharma, S. Oomizu, J. Honda, S. Takeuchi

    Archives of Physiology and Biochemistry   110 ( 1-2 )   34 - 41   2002

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    DOI: 10.1076/apab.110.1.34.895

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  • Identification of a novel GH isoform: A possible link between GH and melanocortin systems in the developing chicken eye Reviewed

    S Takeuchi, M Haneda, K Teshigawara, S Takahashi

    ENDOCRINOLOGY   142 ( 12 )   5158 - 5166   2001.12

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    DOI: 10.1210/en.142.12.5158

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  • Expression and action of hepatocyte growth factor in bovine endometrial stromal and epithelial cells in vitro Reviewed

    S Murakami, Y Miyamoto, C Fujiwara, S Takeuchi, S Takahashi, K Okuda

    MOLECULAR REPRODUCTION AND DEVELOPMENT   60 ( 4 )   472 - 480   2001.12

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    DOI: 10.1002/mrd.1112

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  • Identification of avian alpha-melanocyte-stimulating hormone in the eye: temporal and spatial regulation of expression in the developing chicken Reviewed

    K Teshigawara, S Takahashi, T Boswell, Q Li, S Tanaka, S Takeuchi

    JOURNAL OF ENDOCRINOLOGY   168 ( 3 )   527 - 537   2001.3

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    DOI: 10.1677/joe.0.1680527

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  • Epidermal growth factor stimulates proliferation of mouse uterine epithelial cells in primary culture Reviewed

    M Shiraga, N Komatsu, K Teshigawara, A Okada, S Takeuchi, H Fukamachi, S Takahashi

    ZOOLOGICAL SCIENCE   17 ( 5 )   661 - 666   2000.7

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    DOI: 10.2108/zsj.17.661

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  • Transforming growth factor-alpha stimulates proliferation of mammotrophs and corticotrophs in the mouse pituitary Reviewed

    S Oomizu, J Honda, S Takeuchi, T Kakeya, T Masui, S Takahashi

    JOURNAL OF ENDOCRINOLOGY   165 ( 2 )   493 - 501   2000.5

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    DOI: 10.1677/joe.0.1650493

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  • A possible mechanism for feedback regulation of the mouse tyrosinase gene by its 3 ' non-coding RNA fragments Reviewed

    S Takeuchi, T Takeuchi, H Yamamoto

    PIGMENT CELL RESEARCH   13 ( 2 )   109 - 115   2000.4

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    DOI: 10.1034/j.1600-0749.2000.130209.x

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  • Widespread expression of Agouti-related protein (AGRP) in the chicken: a possible involvement of AGRP in regulating peripheral melanocortin systems in the chicken Reviewed

    S Takeuchi, K Teshigawara, S Takahashi

    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH   1496 ( 2-3 )   261 - 269   2000.4

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    DOI: 10.1016/S0167-4889(00)00022-7

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  • Identification of epidermal growth factor mRNA-expressing cells in the mouse anterior pituitary Reviewed

    J Honda, S Oomizu, Y Kiuchi, N Komatsu, S Takeuchi, S Takahashi

    NEUROENDOCRINOLOGY   71 ( 3 )   155 - 162   2000.3

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    DOI: 10.1159/000054532

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  • Epidermal growth factor, insulin, and estrogen stimulate development of prolactin-secreting cells in cultures of GH3 cells Reviewed

    T Kakeya, S Takeuchi, S Takahashi

    CELL AND TISSUE RESEARCH   299 ( 2 )   237 - 243   2000.2

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    DOI: 10.1007/s004410050021

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  • Immunocytochemical and immuno-electron-microscopical study ofsomatotrophs in ICR and non-obese diabetic(NOD)mice. Reviewed

    Yoshie Manabe, Kazufumi Nakatomi, Mayumi Chikaraishi, Sakae Takeuchi, Yuta Kobayashi, Sumio Takahashi

    Cells Tissues Organs   166 ( 1 )   31 - 39   2000

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    DOI: 10.1159/000016706

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  • Molecular cloning and characterization of the chicken pro-opiomelanocortin (POMC) gene Reviewed

    S Takeuchi, K Teshigawara, S Takahashi

    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH   1450 ( 3 )   452 - 459   1999.7

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    DOI: 10.1016/S0167-4889(99)00046-4

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  • A possible involvement of melanocortin 3 receptor in the regulation of adrenal gland function in the chicken Reviewed

    S Takeuchi, S Takahashi

    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH   1448 ( 3 )   512 - 518   1999.1

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    DOI: 10.1016/S0167-4889(98)00165-7

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  • Evolutionarily conserved telomeric location of BBC1 and MC1R on a microchromosome questions the identity of MC1R and a pigmentation locus on chromosome 1 in chicken Reviewed

    A Sazanov, J Masabanda, D Ewald, S Takeuchi, M Tixier-Boichard, J Buitkamp, R Fries

    CHROMOSOME RESEARCH   6 ( 8 )   651 - 654   1998.12

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    DOI: 10.1023/A:1009269830117

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  • Melanocortin receptor genes in the chicken - Tissue distributions Reviewed

    S Takeuchi, S Takahashi

    GENERAL AND COMPARATIVE ENDOCRINOLOGY   112 ( 2 )   220 - 231   1998.11

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    DOI: 10.1006/gcen.1998.7167

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  • Augmentation of prolactin release by alpha-melanocyte stimulating hormone is possibly mediated by melanocortin 3-receptors in the mouse anterior pituitary cells Reviewed

    Y Morooka, S Oomizu, S Takeuchi, S Takahashi

    ZOOLOGICAL SCIENCE   15 ( 4 )   567 - 572   1998.8

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    DOI: 10.2108/zsj.15.567

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  • Insulin-like growth factor-I and its receptor in mouse pituitary glands Reviewed

    J Honda, S Takeuchi, H Fukamachi, S Takahashi

    ZOOLOGICAL SCIENCE   15 ( 4 )   573 - 579   1998.8

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    DOI: 10.2108/zsj.15.573

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  • Expression of neural cell adhesion molecules in the mouse anterior pituitary gland and pituitary tumor cells Reviewed

    Y Yayoi, S Takahashi, S Takeuchi, M Takeuchi, T Seki, Y Arai

    BIOMEDICAL RESEARCH-TOKYO   19 ( 4 )   269 - 277   1998.8

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    DOI: 10.2220/biomedres.19.269

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  • Stimulatory effect of insulin-like growth factor I on proliferation of mouse pituitary cells in serum-free culture Reviewed

    S Oomizu, S Takeuchi, S Takahashi

    JOURNAL OF ENDOCRINOLOGY   157 ( 1 )   53 - 62   1998.4

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    DOI: 10.1677/joe.0.1570053

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  • Molecular cloning of the chicken melanocortin 2(ACTH)-receptor gene. Reviewed

    S Takeuchi, T Kudo, S Takahashi

    Biochimica et Biophysica Acta   1403 ( 1 )   102 - 108   1998

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    DOI: 10.1016/S0167-4889(98)00022-6

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  • Insulin-like growth factor-I stimulates proliferation of mouse uterine epithelial cells in primary culture Reviewed

    M Shiraga, S Takahashi, T Miyake, S Takeuchi, H Fukamachi

    PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE   215 ( 4 )   412 - 417   1997.9

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    DOI: 10.3181/00379727-215-44152

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  • Insulin-like growth factor-Ⅰ system in the mouse pituitary Reviewed

    Advances in Comparative Endocrinology   1123 - 1126   1997

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  • メラノコルチン受容体 Invited

    生体の科学,医学書院   48 ( 5 )   426 - 429   1997

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    DOI: 10.11477/mf.2425901240

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  • Possible involvement of melanocortin 1-receptor in regulating feather color pigmentation in the chicken Reviewed

    Sakae Takeuchi, Hideyuki Suzuki, Masafumi Yabuuchi, Sumio Takahashi

    Biochimica et Biophysica Acta - Gene Structure and Expression   1308 ( 2 )   164 - 168   1996.8

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    DOI: 10.1016/0167-4781(96)00100-5

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  • Molecular cloning and sequence analysis of the chick melanocortin 1-receptor gene Reviewed

    Sakae Takeuchi, Hideyuki Suzuki, Sayoko Hirose, Masafumi Yabuuchi, Chikara Sato, Hiroaki Yamamoto, Sumio Takahashi

    Biochimica et Biophysica Acta - Gene Structure and Expression   1306 ( 2-3 )   122 - 126   1996.5

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    DOI: 10.1016/0167-4781(96)00026-7

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  • Phylogeny of Regulatory Regions of Vertebrate Tyrosinase Genes Reviewed

    HIROAKI YAMAMOTO, TOSHIYUKI KUDO, NORIO MASUKO, HIROHITO MIURA, SHIGERU SATO, MIKA TANAKA, SATOSHI TANAKA, SAKAE TAKEUCHI, SHIGEKI SHIBAHARA, TAKUJI TAKEUCHI

    Pigment Cell Research   5 ( 5 )   284 - 294   1992.11

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    DOI: 10.1111/j.1600-0749.1992.tb00551.x

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  • Structural Changes and Morphometric Analysis of the Pituitary Gland after Hemorrhage Induced by Intraperitoneal Injection of Hypertonic Solution in Mice Reviewed

    Ichiro Koshimizu, Naoko Awamura, Sakae Takeuchi, Yasuo Kobayashi

    Biomedical Research (Japan)   13 ( 4 )   253 - 258   1992.8

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    DOI: 10.2220/biomedres.13.253

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  • The strain-dependent constitutive expression of murine serum amyloid-P component is regulated at the transcriptional level

    Yohjiro Itoh, Sakae Takeuchi, Kazuhiro Shigemoto, Sachiho Kubo, Setsuko Handa, Naoshi Ishikawa, Naoki Maruyama

    BBA - Gene Structure and Expression   1131 ( 3 )   261 - 269   1992.7

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    DOI: 10.1016/0167-4781(92)90024-T

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  • THE STRAIN-DEPENDENT CONSTITUTIVE EXPRESSION OF MURINE SERUM AMYLOID-P-COMPONENT IS REGULATED AT THE TRANSCRIPTIONAL LEVEL Reviewed

    Y ITOH, S TAKEUCHI, K SHIGEMOTO, S KUBO, S HANDA, N ISHIKAWA, N MARUYAMA

    BIOCHIMICA ET BIOPHYSICA ACTA   1131 ( 3 )   261 - 269   1992.7

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  • A MORPHOMETRIC STUDY ON PITUITARY PARS-INTERMEDIA CELLS OF MALE-MICE FED A LIQUID DIET SUPPLEMENTED WITH UREA Reviewed

    M OKADA, M OKADA, S TAKEUCHI, Y KOBAYASHI, Y KOBAYASHI

    ZOOLOGICAL SCIENCE   8 ( 5 )   899 - 903   1991.10

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  • Melanization in albino mice transformed by introducing cloned mouse tyrosinase gene Reviewed

    S. Tanaka, H. Yamamoto, S. Takeuchi, T. Takeuchi

    Development   108 ( 2 )   223 - 227   1990.2

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  • Melanin production in cultured albino melanocytes transfected with mouse tyrosinase cDNA Reviewed

    Hiroaki Yamamoto, Sakae Takeuchi, Toshiyuki Kudo, Chikara Sato, Takuji Takeuchi

    The Japanese Journal of Genetics   64 ( 2 )   121 - 135   1989.4

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    DOI: 10.1266/jjg.64.121

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  • Expression of tyrosinase gene in amelanotic mutant mice Reviewed

    Sakae Takeuchi, Hiroaki Yamamoto, Takuji Takeuchi

    Biochemical and Biophysical Research Communications   155 ( 1 )   470 - 475   1988.8

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    DOI: 10.1016/S0006-291X(88)81110-0

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  • Cloning and sequencing of mouse tyrosinase cDNA Reviewed

    Hiroaki Yamamoto, Sakae Takeuchi, Toshiyuki Kudo, Kozo Makino, Atsuo Nakata, Tomotaka Shinoda, Takuji Takeuchi

    The Japanese Journal of Genetics   62 ( 3 )   271 - 274   1987.6

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    DOI: 10.1266/jjg.62.271

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Books

  • Handbook of hormones : comparative endocrinology for basic and clinical research

    安東, 宏徳, Ukena, Kazuyoshi, Nagata, Shinji( Role: Contributor ,  Chapter 8. Agouti Family 8A. Agouti-Signaling Protein 8B. Agouti-Related Protein)

    Academic Press  2021.7  ( ISBN:9780323851947

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  • 生体防御・社会性 : 守

    水澤, 寛太, 矢田, 崇( Role: Contributor ,  9.鳥類と哺乳類の保護色)

    裳華房  2016.10  ( ISBN:9784785351205

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    Total pages:xiv, 258p, 図版 [6] p   Language:Japanese

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  • Handbook of hormones : comparative endocrinology for basic and clinical research

    竹井, 祥郎, 安東, 宏徳, 筒井, 和義( Role: Contributor ,  Chapter 8. Agouti Family 8A. Agouti-Signaling Protein 8B. Agouti-Related Protein)

    Academic Press is an imprint of Elsevier  2016  ( ISBN:9780128010280

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    Total pages:xxvii, 646 p.   Language:English

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  • 黒色素胞刺激ホルモン(MSH)とその受容体

    ストレスとホルモン(ホルモンの分子生物学シリーズNo.5),日本比較内分泌学会編,学会出版センター  1997 

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Research Projects

  • Structuring of hormonal system controlling feather formation in birds

    Grant number:23K05851  2023.04 - 2026.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    竹内 栄

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    Grant amount:\4680000 ( Direct expense: \3600000 、 Indirect expense:\1080000 )

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  • 皮膚付属器のホルモン応答性の部域差を創出する分子基盤の解明

    Grant number:20K06721  2020.04 - 2023.03

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    竹内 栄

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    Grant amount:\4290000 ( Direct expense: \3300000 、 Indirect expense:\990000 )

    鳥類の羽は哺乳類の毛と同様に,表皮細胞に由来する皮膚付属器である。ニワトリでは,鞍羽に顕著な性差が見られ,雌では褐色(ユーメラニン色)を呈する丸型羽であるのに対し,雄では光沢のある赤褐色(フェオメラニン色)の飾り羽で,尖った先端部には小羽枝を欠くフリンジ構造がみられる。羽の性差形成については雄型の羽が雌雄に共通なデフォルトであり,雌型羽は卵巣由来のエストロゲンの作用によって形成れること,このエストロゲン作用には甲状腺ホルモンが不可欠であること, 甲状腺ホルモン欠乏下では,性とは無関係に雄鞍羽に類似なフリンジ構造をもつ光沢のある赤褐色羽が形成されることなどが知られていたが,羽形成におけるホルモン作用の分子機構については不明な点が多く残されてきた。本研究では,ニワトリの羽形成におけるエストロゲン系,メラノコルチン系,甲状腺ホルモン系のクロストークおよび,遅羽遺伝子の解析を通して,甲状腺ホルモンと酷似した働きが報告されているプロラクチンの羽形成における作用機序の検討を行ってきた。本年度は,これらのホルモン系のクロストークの場である羽髄細胞の初代培養系をもちいた解析から,プロラクチンが様々な細胞成長因子や甲状腺ホルモン系因子の発現制御に関わることを明らかにするとともに,甲状腺ホルモン受容体の新規バリアントを同定し発現解析や機能解析から甲状腺ホルモン系の新たな制御系の可能性が示唆された。さらに,マイクロアレイのデータ解析,およびRNAseq解析から羽の性差形成に関わると考えられる候補因子を検討した。

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  • Elucidation of hormonal regulation of feather formation in chickens

    Grant number:17K07471  2017.04 - 2020.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    TAKEUCHI Sakae

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    Grant amount:\4940000 ( Direct expense: \3800000 、 Indirect expense:\1140000 )

    The feathers of birds are skin appendages composed of dead epidermal cells like mammalian hair. In chickens, there is a marked sex difference in the saddle feathers. In this study, we used this saddle feather as a model system to analyze the molecular mechanism of the formation of sex difference in the skin appendage. In addition, we analyzed the molecular mechanism of the late feathering widely used for autosexing of day-old chicks in hatcheries. Our results suggest that various hormone systems such as sex hormones and melanocortins cross-talk with each other to form proper feathers, and that slow feathering is caused by quantitative changes in prolactin signaling.

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  • Roles of transcription factor Runx 3 in ovarian follicle development and ovulation in mice

    Grant number:26440167  2014.04 - 2017.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Takahashi Sumio, FUKAMACHI Hiroshi, TAKEUCHI Sakae, SAKUMA Atsuko, TSUCHIYA Yukiko, SAITO Yuka, OGO Yuki, OJIMA Fumiya, HAYASHI Sayo, KAYO Daichi, MAEKAWA Tetsuya, GU TinTin

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    Grant amount:\4940000 ( Direct expense: \3800000 、 Indirect expense:\1140000 )

    The present study was aimed at clarifying the roles of transcription factor Runx3 in female mice. Runx3 mRNA was detected in the granulosa cells of ovaries, and in the neural cells in hypothalamic areas involved in regulation of ovulation in female mice. In Runx3 knockout female mice, hypothalamic Kisspeptin mRNA and ovarian cholesterol side-chain cleavage enzyme gene mRNA expressions were decreased. Dysfunction of hypothalamic regulatory mechanism of ovulation in Runx3 knockout female mice was demonstrated. These findings clearly suggest that Runx3 was involved in the regulation of ovarian steroid hormone production and hypothalamic ovulatory function.

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  • Molecular mechanism of sexual dimorphism and age-dependent changes in feather coloration

    Grant number:23570078  2011 - 2013

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    TAKEUCHI Sakae

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    Grant amount:\5460000 ( Direct expense: \4200000 、 Indirect expense:\1260000 )

    Brilliant plumage is typical of male birds, thus sexual plumage dichromatism is seen in many avian species; however, the molecular mechanism underlying this remains unclear. In Okayama-Jidori chickens, chick and adult female plumages are countershading with dull-colored feathers. In contrast, adult males are colorful with bright ornamental feathers on the back. Using this breed, we investigated molecular mechanism underlying the sexual plumage dichromatism in birds.
    Our findings suggest that the local melanocortin system regulates feather pigmentation and the elaborate color pattern of individual feathers is formed in part by the antagonistic action of ASIP. Furthermore, the distal ASIP promoter not only acts to produce countershading in chicks and adult females, but also plays an important role for creating sexual plumage dichromatism. The ASIP gene may have been modified in its expression during evolution to develop phenotypic diversity between individuals of different sexes.

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  • Regulatory mechanism of breakdown and reconstruction of reproductive organs

    Grant number:19370025  2007 - 2009

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    TAKAHASHI Sumio, TAKEUCHI Sakae, FUKAMACHI Hiroshi

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    Grant amount:\17940000 ( Direct expense: \13800000 、 Indirect expense:\4140000 )

    Proliferation, differentiation and apoptosis (programmed cell-death) are regulated by signaling molecules secreted from cells, hormones, growth factors and cytokines, and by extracellular matrices surrounding cells. The present study was aimed at studying regulatory mechanism of the proliferation and apoptosis in the mouse pituitary and uterus. We showed regulatory mechanisms of gene expression of growth factors and hormones that were associated with proliferation in the pituitary and uterus, and also factors which modified actions of growth factors and hormones.

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  • Studies on the physiological roles of melanocortin receptor antagonists in birds

    Grant number:19570059  2007 - 2008

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    TAKEUCHI Sakae

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    Grant amount:\4680000 ( Direct expense: \3600000 、 Indirect expense:\1080000 )

    ニワトリの雛や成鶏雌にみられる保護色パターン, 及び成鶏雄に特徴的な婚姻色パターンが, ASIP遺伝子の同一プロモーターの働きによって形成されることが明らかになった。これは, 体色における性差発現の分子機序に関する初めての成果である。また, ニワトリ視床下部におけるASIP発現は, 絶食負荷や高エネルギー食負荷により変動しないことから, 摂食制御以外の機能を持つか, 変異に起因する異所発現である可能性が示唆された。

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  • Physiological role and molecular mechanism of a novel growth hormone sGH system in the chicken

    Grant number:16570054  2004 - 2005

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    TAKEUCHI Sakae

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    Grant amount:\3700000 ( Direct expense: \3700000 )

    The chicken growth hormone (GH) gene produces two distinct GH mRNAs by alternative usage of two transcription initiation sites : the pituitary GH (p-GH) mRNA encoding circulating GH, and the extra-pituitary GH mRNA encoding a GH cytosolic isoform (s-GH). The s-GH mRNA is transcribed from the third intron of the GH gene which consists of 5 exons and 4 introns (1). Here we demonstrate for the first time that the chicken GH gene is bi-directionally transcribed in a wide variety of tissues to produce GH sense (p-GH and/or s-GH) mRNAs and multiple alternatively spliced anti-sense transcripts. Seven GH anti-sense (GH-as) transcripts with distinct exon composition were isolated by RT-PCR with RNA from embryonic chicken eyes. The 5' and 3' RACE revealed that their transcription initiates in the 3' downstream from the poly (A) site of the GH sense mRNAs, and each transcript was polyadenylated by using either of three poly (A) signals located 5' upstream from the promoter for p-GH mRNA. Those GH-as transcripts were composed of at least 5 exons, most of which overlap exons of the GH sense mRNAs. Interestingly, no open reading frame expanding over plural exons was observed in all GH-as transcripts. The RT-PCR analysis revealed that the GH sense mRNAs and the GH-as transcripts are co-expressed widely in adults and 3-day-old chickens, and the relative abundance of GH sense mRNAs and GH-as transcripts varied with tissue types. Moreover, the B-cell cell line DT40 expressed both GH sense mRNAs and GH-as transcripts, indicating that the bi-directional transcription occurs in a single cell. Protein analyses are required ; however, these findings imply the possibility that p-GH and/or s-GH expression is regulated at post-transcriptional levels by interaction between GH sense and anti-sense transcripts in the chicken.

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  • Crosstalk between immune cells and corpus luteum cells in regulating luteolysis and its application for animal reproduction

    Grant number:14360168  2002 - 2004

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    OKUDA Kiyoshi

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    Grant amount:\14200000 ( Direct expense: \14200000 )

    The intra-luteal regulators consist of peptides, eicosanoids, growth factors, cytokines, and neurotransmitters produced by corpus luteum cells and immune cells. In the present studies, the roles of locally produced substances in the control of luteolysis were studied. The results obtained in this research lead us to the following conclusions :
    1.A Fas/Fas L system is present in bovine luteal endothelial cells, and leukocyte-derived cytokines play important roles in Fas-mediated luteal cell death.
    2.Intra-luteal P4 suppresses apoptosis in bovine luteal cells through the inhibition of Fas and caspase-3 mRNA expression and inhibition of caspase-3 activation.
    3.Genes for IL-1α and IL-1β are expressed and a functional IL-1R is present in the bovine CL throughout the luteal phase. IL-1a and IL-1b seem to have different roles in a paracrine manner to regulate PGF2α and PGE2 production during the luteal phase.
    4.Nitric oxide participates in the functional regression of the bovine CL by inhibiting steroidogenesis.
    5.Low levels of TNFα causes luteolysis, whereas high levels of TNFα activates CL function and prolongs the estrous cycle in cattle. TNFα seems to play some crucial roles in both luteolysis and establishment of pregnancy.
    6.A review focusing on recent studies documenting the expression of TNFα and Fas L, their receptors, and intracellular signaling mechanisms in the CL has been invited to summarize the present project theme. The review has been published in Reproductive Biology and Endocrinology.

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  • Study on intraocular expression of pituitary hormones possibly involved in the regulation of retinal development in the chicken

    Grant number:14540615  2002 - 2003

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    TAKEUCHI Sakae, TAKAHASHI Sumio

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    Grant amount:\3000000 ( Direct expense: \3000000 )

    We have demonstrated previously that immunoreactive α-melanocyte-stimulating hormone (α-MSH) and growth hormone (GH) are expressed in developing chicken retinas with developmentally regulated patterns. The major aim of the present study was to examine their expression and other pituitary hormones at transcriptional level. RT-PCR revealed that pituitary-specific transcription factor, Pit-1, was expressed in embryonic chicken neural retinas. The Pit-1-regulated hormones, such as prolactin (PRL), thyrotropin (TSH), GH, and their receptors were also found to be expressed. Since their expression levels in the neural retinas were very low when compared with those in the pituitary, it is possible that they act as local mediators to regulate ocular development. Pro-opiomelanocortin, a common precursor of melanocortin peptides and other peptide hormones, was expressed in the neural retinas as well as in retinal pigment epithelial (RPE) cells. Two prohormone convertases, PC 1 and PC2, were cloned and their specific primers were designed based on the sequences obtained in this study. Using the primers, we demonstrated that PC1 and PC2 were co-expressed in both the neural retinas and RPE cells, supporting our previous finding that a MSH is expressed intraocularly. These findings suggest that neural retina is another site of pituitary hormone production during embryonic development in the chicken. Interestingly, we found for the first time that the chicken GH gene produces anti-sense-GH (GH-as) transcripts. Their transcription from the opposite strand of GH starts with downstream of the polyadenylation site of GH-sense mRNAs and ends with upstream of the TATA box for pituitary GH mRNA. More than 6 types of GH-as transcripts with different exon composition were identified. Since no open reading frames (ORFs) were detected in the GH-as transcripts, it is possible that they act as regulators of GH translation by interacting with GH-sense mRNAs though further analyses are required. We also performed additional analyses to clarify whether α-MSH has physiological roles, which may help us to study on the role of α-MSH in ocular development.

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  • 血管内皮細胞のアポトーシス誘導による抗血管新生療法の開発

    Grant number:14656115  2002 - 2003

    日本学術振興会  科学研究費助成事業 萌芽研究  萌芽研究

    奥田 潔, 竹内 栄

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    Grant amount:\3400000 ( Direct expense: \3400000 )

    昨年度はウシ黄体細胞由来血管内皮細胞においてFas mRNA発現が認められ、腫瘍壊死因子(TNFα)およびインターフェロン(IFN)-γがFasを介レたアポトーシス誘導機構に関与していることを明らかにした。本年度は、(1)成長因子のFasを介したアポトーシスにおよぼす影響、(2)アポトーシス誘導機構または抑制機構のメカニズム(bcl-2ファミリーのmRNA発現)、(3)血管内皮細胞にFas遺伝子導入を行うことによるアポトーシス誘導モデルの作出について検討した。
    1.TNFα、IFNγおよびFasリガンドの添加に加え、成長因子(VEGF,IGE,bFGE,EGF)を単独または組み合わせて添加し、血管内皮細胞の細胞死およびアポトーシスの指標となるアポトーシス小体ならびにDNAの断片化についてそれぞれ検討した。その結果、VEGF単独または、VEGFと他の成長因子の組み合わせ添加において、TNFα、IFNγおよびFasリガンドの誘導するアポトーシスが抑制された。さらに、これらの添加区においてアポトーシス小体ならびにDNAの断片化が減少した。
    2.1.の各添加区において、bcl-2およびbax mRNA発現について検討した。その結果、アポトーシスの抑制が認められたVEGF単独または、VEGFと他の成長因子を組み合わせた添加区において、baxに対するbcl-2発現の割合が高くなった。
    3.血管内皮細胞にFas遺伝子導入をしたアポトーシス誘導モデルマウスの作出を試みたが、生存能力が極めて低く、目的としている部位にFasリガンドを注入する実験には至らなかった。
    以上の結果から、ウシ黄体の血管内皮細胞において、VEGFなどの成長因子はFasを介したアポトーシスに対する抑制作用をもち、その作用はbaxに対するbcl-2発現を高めることによることが示唆された。今後は、アポトーシス誘導モデルマウスを改良し、生体におけるアポトーシス誘導機構の詳細について検討していく予定である。

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  • インターロイキン18の生殖内分泌系における新しい作用の解析

    Grant number:14654172  2002 - 2003

    日本学術振興会  科学研究費助成事業 萌芽研究  萌芽研究

    高橋 純夫, 奥田 潔, 竹内 栄

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    Grant amount:\3400000 ( Direct expense: \3400000 )

    マウス精巣,卵巣,子宮においてイシターロイキン18およびその受容体mRNAが発現していることを見いだした.本研究では,発情周期や妊娠といった生殖系の機能発現において細胞の増殖などの動的な変化を示す子宮に着目し,IL-18遺伝子発現の解析を行った.子宮におけるIL-18 mRNAの発現が確認されるため,in situハイブリダイゼーション解析によりIL-18 mRNAを発現する細胞の同定をおこなった.3週齢未成熟マウスにおいて,子宮内膜上皮細胞,間質細胞の両方にIL-18mRNAシグナルが検出された.しかし9週齢マウスにおいては,上皮細胞にIL-18 mRNAシグナルは検出されなかった.この変化には,発情周期が開始されたことによる血中のさまざまなホルモン,特に性ステロイドの濃度が影響していることが考えられる.そこで,発情周期によって,血中濃度が大きく変化し,子宮内膜細胞の増殖に大きな影響を及ぼすエストロゲンなどの性ステロイドがIL-18及びIL-18Rα mRNAの発現にどのような影響を及ぼすか,RNase Protection解析を実施した.
    卵巣を摘出したマウスにエストラジオール-17β(E_2)を投与し,経時的にIL-18およびIL-18Rα mRNA量を解析した.いずれのmRNA量も,E_2投与12時間後には減少し,その後48時間後には投与前と同程度にまで回復することが明らかとなった.このように,IL-18及びその受容体の遺伝子発現に対し生殖系の因子エストロゲンが大きな影響を及ぼしていることが明らかになった.このことは,IL-18が生殖系の機能発現に対し何らかの作用を持つことを示唆している.

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  • Molecular and cellular analysis of autocrine and paracrine functions of endometrial growth factors

    Grant number:13440247  2001 - 2003

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    TAKAHASHI Sumio, OKUDA Kiyoshi, TAKEUCHI Sakae

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    Grant amount:\14800000 ( Direct expense: \14800000 )

    The growth and functions of uterine endometrial cells are regulated by estrogen and progestins. The actions of these sex steroid hormones are thought to be mediated by growth factors and cytokines produced, within the endometrium. The present study was aimed to clarify molecular and cellular regulatory mechanism of gene expression of growth factors and cytokines in the mouse endometrium. Estradiol stimulated transcription of insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), transforming growth factor a (TGF-α), and TGF-β2 genes, and decreased interleukin-18 (IL-18) mRNA level. Progesterone decreased TGF-β1 and TGF-β3 mRNA levels. Thus, the gene expression of all growth factors studied is regulated by estrogen or progestin. Our in vitro study revealed that IGF-I, EGF and TGF-α stimulated DNA replication of endometrial cells. The IGF-I action in terms of DNA replication was mediated by IGF-I type I receptors through MAPkinase and PI3kinase pathways. Combination of estradiol and progesterone stimulated the DNA replication of endometrial stroma cells, and this stimulatory action of the sex steroids was reduced by an EGF-receptor inhibitor RG13022. This result indicates that the stimulatory action by combination of estradiol and progesterone is mediated through EGF receptor signaling using ligands of EGF family-growth factors. These growth factors regulate proliferation of endometroial cells under stimulatory stimuli of estrogen. Estradiol and TGF-α decreased estrogen receptorα mRNA level, suggesting negative feedback system of estrogen action at the estrogen receptor level. Matrix metaloproteinases (MMPs) are thought to be associated with the growth and remodeling of the endometrium. MMP3, MMP7 and MMP9 mRNA levels were analyzed in mouse endometrium. These MMP mRNA levels increased at estrus, in adult mice. In vitro study estradiol decreased MMP3 mRNA levels at 24 hours. The findings altogether suggest that growth factors, cytokines and MMPs are associated with the growth and functions of uterine endometrium.

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  • 下垂体ホルモンの下垂体外発現の生理学的意義と局所的ホルモン調節系の分子機構に関する研究

    2001

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    Grant type:Competitive

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  • Study on molecular mechanism of melanocyte-stimulating hormone system in the chicken

    Grant number:12640650  2000 - 2001

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    TAKEUCHI Sakae, TAKAHASHI Sumio

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    Grant amount:\3600000 ( Direct expense: \3600000 )

    1. The presence and possible physiological roles of a-MSH in the peripheral tissues of birds have not established. By a combination of RT-PCR, immunocytochemitry and in situ hybridization, we identified the expression of a-MSH in the eye, which is regulated temporally and spatially in the developing chicken. The data clearly indicated that the retinal pigment epithelial cells (RPE cells) and the cone cells are intraocular sources of a-MSH in the embryonic and postnatal life of the chicken, respectively. Embryonic expression of a-MSH in the RPE cells implies a possible role for the peptide in ocular development This is the first report demonstrating the expression of a-MSH in peripheral tissues in birds, and supports our hypothesis that avian a-MSH is a paracrine/autocrine hormone.
    2. Growth hormone (GH) is considered to play a role in the phatogenesis of diabetic retinopathy. RT-PCR and 5'RACE analysis identified a novel GH isoform expressed in the developing chicken eye. Immunocytochemistry revealed that the binding of the novel GH isoform, named as s-cGH, to GH receptors in the RPE cells is temporally regulated and correlates well with the production of a-MSH in the RPE cells during embryonic development, implying a possible involvement of s-CGH in the regulation of ocular development.
    3. The neural mechanisms involved in the compensatory hyperphagia exhibited by many vertebrate species after a fast are not fully understood but, in mammals, appear to involve neutritionally-sensitive neurons that co-express neuropeptide Y (NPY) and agouti-related protein (AGRP) in the infundibular hypothalamus. We investigated whether these neurons have been evolutionarily conserved in a non-mammalian vertebrate, the Japanese quail. Double-label in situ hybridization revealed that majority of NPY neurons in the infundibular nucleus co-express AGRP mRNA, indicating that this cell type has been neuroanatomically and functionally conserved during vertebrate evolution. .

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  • Evaluation systems for individual sensitivity against ultraviolet light using one hair alone

    Grant number:11558067  1999 - 2001

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    YAMAMOTO Kazuo, TAKEUCHI Sakae, IDE Hiroshi, YAMAMOTO Hiroaki, SUZUKI Itaru

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    Grant amount:\13800000 ( Direct expense: \13800000 )

    This project has been intended to devise system that can monitor individual UV sensitivity by measuring transcriptional expression of tyrosinase or repair genes, which is known to defend from the deleterious effects of UV radiation.
    1) The 5' upstream regulatory region of the mouse tyrosinase gene contains a long (GA)n sequence, that may be capable adopting a triple-helical conformation (triplex). The results suggest that the 3'non-coding RNA fragments of mouse tyrosinase transcripts suppress its own expression at the transcriptional level. This might occur by preventing cell type-specific protein factor(s) from binding to the regulatory cis-elements in the 5' upstream region of the gene, possibly through a triplex formation.2) Tyrosinase is the key enzyme for synthesizing melanin pigments, which primarily determine mammalian skin coloration. We provide evidence that 5'flanking sequences from nonmammalian genes are functional in vivo by producing transgenic mice. 3) Microphthalmia-associated transcription factor (MITF) plays a critical role in the development of both neural-crest-derived melanocytes and optic cup-derived retinal pigmented epithelium (RPE). We found that melanocyte development depends critically on a single Mitf isoform, Mitf-M. 4) We have established an in situ hybridization technique to investigate mRNA levels of pro-opiomelanocortin, tyrosinase, tyrosinase-related protein-1, dopachrome tautomerase, P-protein, Pmel-17/gp100, and microphthalmia-associated transcription factor. Results suggest that the mechanism of the tanning response of human skin may involve the transcriptional regulation of certain pigmentary genes. 5) Using an antibody to detect UV damage and anti-UvrA antibody, we measured the repair ability of recA strain of E. coli. Our results indicate that constitutive level of UvrA protein in the recA cells results in constitutive levels of active UvrABC nuclease which is not enough to operate full nucleotide excision repair (NER), thus leading to extreme UV sensitivity.

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  • Cellular and molecular study of sex steroid- and growth factor-mediated regulatory mechanism of mouse uterine endometrial cells

    Grant number:11640665  1999 - 2000

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    TAKAHASHI Sumio, TAKEUCHI Sakae

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    Grant amount:\4000000 ( Direct expense: \4000000 )

    Proliferation of mammalian uterine endometrial cells is regulated by ovarian sex steroids and growth factors. Uterine endometrium consists of a single epithelial cell layer and the underlying stromal cell layer, The mouse endometrium was reorganized in vitro culture system. In this three-dimensional culture system of mouse endometrial cells, the proliferation of the epithelial cells was increased by the presence of the underlying stromal cells. This result suggests that the stromal cells affect epithelial cell functions including the cell growth. The stromal cells produced epidermal growth factor (EGF), transforming growth factor -α(TGF-α) and EGF-receptors (EGF-R). EGF and TGF-α stimulated the proliferation of stromal cells. A combined treatment of estradiol and progesterone also stimulated the proliferation of stromal cells, but RG-13022, a specific inhibitor of EGF-R, nullified the stimulatory effect of estradiol and progesterone. A combined treatment of estradiol and progesterone increased TGF-α mRNA levels, but not EGF mRNA levels. EGF-R mRNA levels was enhanced by a combined treatment of estradiol and progesterone. These results indicate that the growth of stromal cells was regulated by estradiol and progesterone, and this action was mediated by TGF-α. The present study demonstrated that proliferation of mouse uterine endometrial stromal cells was stimulated by a paracrine action of TGF-α, whose synthesis in the stromal cells was regulated by ovarian estrogen and progesterone.

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  • 脊椎動物MSH受容体遺伝子のクローニングと塩基配列分析

    Grant number:06740629  1994

    日本学術振興会  科学研究費助成事業 奨励研究(A)  奨励研究(A)

    竹内 栄

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    Grant amount:\900000 ( Direct expense: \900000 )

    本研究課題では、鳥類に於けるMSHの生理作用を調べると共に、鳥類に見られるMSHの主要分泌器官、下垂体中葉消失の原因を知る手がかりを得ることを目的としてニワトリMSHリセプター遺伝子のクローニングを試みた。既得のマウス色素細胞特異的MSHリセプター(MC1-R)cDNAをプローブとしたニワトリゲノムDNAサザン解析の結果、およそ1.8kbのBamHl断片を検出した。同プローブを用いたゲノムDNAライブラリーのスクリーニングの結果、この断片を含むクローンを得た。塩基配列を決定したところ分子量35297Daのペプチドをコードする翻訳領域を含んでいた。このペプチドは、N末端側に3カ所の糖鎖付加部位を持ち、Gタンパクにカップリングしたリセプターに共通な7つの膜貫通ドメインを有した。ホモロジー検索を行ったところ哺乳類で発表されているMC1-Rに最も高い相同性を示した。これらの事実から得られた遺伝子は、ニワトリに於けるMC1-Rであると結論づけた。この遺伝子は、哺乳類同様イントロンを持たず、その5´上流および3´下流には、これまでに薬理学的・細胞生物学的に示唆されていたMSHリセプターに関する緒知見を裏付けるいくつかの遺伝子発現調節エレメントが観察された。また、興味深いことにこのリセプターは、ホルモン非依存的活性を示す可能性が示唆された。このことは、鳥類において、下垂体中葉が退化した理由を考える上で有用な知見を与えてくれるものと考えられる。

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  • アマガエル黒色素胞特異的cDNAのクローニング

    Grant number:05740507  1993

    日本学術振興会  科学研究費助成事業 奨励研究(A)  奨励研究(A)

    竹内 栄

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    Grant amount:\800000 ( Direct expense: \800000 )

    本研究課題では、当初アマゲエルのMSH標的細胞を同定するプローブを得るため、受容体cDNAのクローニングを計画していた。しかし、最近、哺乳類のMSH受容体遺伝子が遺伝子群を為し個々が細胞種特異的に発現すること、それらがいずれもイントロンレスであることが報告されたことから、クローニングの対象をゲノムDNAに変更した。実験は、まずマウス色素細胞由来のMSH受容体cDNAをプローブとしたゲノミックサザン法による相同配列の検出を試みた。その結果、微かな陽性シグナルが観察されたが、関連配列(遺伝子群)の検出までには至らなかった。これは、用いたプローブが異種生物由来のDNAであったこと、非RI検出法(酵素抗体法)であったことなどによる低検出感度に原因があったと考えられる。そこで、次にlambda-GEM11をベクターとするゲノムDNAライブラリーを作製し、直接遺伝子のクローン化を試みた。その結果、構造の異なる2種類の遺伝子に由来する数クローンを得た。その構造解析から、興味深いことに両遺伝子とも複数コピータンデムにゲノム中に存在することが明らかになった。これらの遺伝子が機能しているのか否か、更に発現細胞の同定は今後の課題である。
    MSHの生理的作用は、進化により多様化がみられることが知られる。哺乳類でクローン化されたMSH受容体遺伝子群が互いに相同性を示すこと、および本研究で得られた知見、即ち両生類に於いて受容体遺伝子の増幅が観察されたことを総合すると、MSHは、その受容体遺伝子の増幅と分化によって機能の多様化を獲得したものと考えられる。今後は、更に系統発生学的にこの遺伝子の存在様式を解析し、上述の仮説を立証すると共に、本研究で得られたDNAをプローブとして用い、MSH標的細胞同定、機能検索を行いたいと考えている。

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  • メラノコルチン機能及びその受容体遺伝子に関する系統発生学的研究

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  • Study on proliferation and differentiation of utenus and pituitary cells

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  • Phylogenic Study on Melanocortin Function and their Receptor Genes

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  • Phylogenic Study on MSH Function and Its Receptor Gene

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  • 子宮及び下垂体細胞の増殖・分化に関する研究

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  • Introduction to Innovation (2024academic year) Late  - 月7~8,金7~8

  • Introduction to Innovation (2024academic year) Late  - 月7~8

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  • Advanced Course of Innovation (2024academic year) Prophase  - その他

  • Internship (short term) (2024academic year) Year-round  - その他

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  • Introduction to Earth,Environmental and Life Sciences (2024academic year) Prophase  - 金1~2

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  • Academic presentations (2024academic year) Year-round  - その他

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  • Chronobiology (2024academic year) 3rd and 4th semester  - 月3~4

  • Endocrinology IA (2024academic year) Third semester  - 月3~4

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  • Seminar in Chemical Correlation and Control (2024academic year) Year-round  - その他

  • Intellectual Property (2024academic year) Summer concentration  - その他

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  • Humoral Regulation of Cell Function (2024academic year) Late  - その他

  • Cell Signaling (2024academic year) Late  - 火3~4

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  • Introduction to Natural Science 1(Biology) (2024academic year) 1st semester  - 火3~4

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  • Introduction to Innovation (2023academic year) Late  - その他

  • Introduction to Innovation (2023academic year) Late  - 月7~8,金7~8

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  • Seminar in Chemical Correlation and Control (2023academic year) Year-round  - その他

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  • Cell Signaling (2023academic year) Late  - 火3~4

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  • Introduction to Innovation (2022academic year) Late  - 月7~8,金7~8

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  • Humoral Regulation of Cell Function (2022academic year) Late  - その他

  • Cell Signaling (2022academic year) Late  - 火3~4

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  • Introduction to Natural Science 1(Biology) (2022academic year) 1st semester  - 火3~4

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  • Introduction to Innovation (2021academic year) Late  - 月7~8,金7~8

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  • Basic Biology B (2021academic year) 3rd and 4th semester  - 水3,水4

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  • Seminar in Chemical Correlation and Control (2021academic year) Year-round  - その他

  • Humoral Regulation of Cell Function (2021academic year) Late  - その他

  • Cell Signaling (2021academic year) Late  - 火3,火4

  • Cell Biology 2 (2021academic year) 1st and 2nd semester  - 水1,水2

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  • Introduction to Natural Science 1(Biology) (2021academic year) 1st semester  - 火3~4

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  • Humoral Regulation of Cell Function (2020academic year) Late  - その他

  • Cell Signaling (2020academic year) Late  - 火3,火4

  • Cell Biology 2 (2020academic year) 1st and 2nd semester  - 水1,水2

  • Cell Biology IIA (2020academic year) 1st semester  - 水1,水2

  • Introduction to Natural Science 1(Biology) (2020academic year) 1st semester  - 火3,火4

  • Introduction to Natural Science 2(Biology) (2020academic year) Second semester  - 火3,火4

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Media Coverage

  • 岡山大学の研究が明らかにした羽成長の新メカニズムとは Internet

    サードニュース  2025.1

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  • 【岡山大学】プロラクチンが羽成長を促進する分子メカニズムの解明~インスリン様成長因子と甲状腺ホルモンが協働し急速な成長を実現~ Internet

    山陽新聞デジタル・紀伊民報AGARA・Exciteエキサイト・産経新聞・JIJI.COM・BIGLOBEニュース・愛媛新聞・NIKKEI COMPASS・  2025.1

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  • 岡山大学の新発見!羽毛形成に関わる遺伝子PBCFの詳細 Internet

    サードニュース  2025.1

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  • 【岡山大学】鳥類の羽毛形成に関わる新規遺伝子「PBCF」を発見~羽毛の進化と発生のメカニズムに新たな光~ Internet

    山陽新聞デジタル・Mapionニュース・紀伊民報AGARA・愛媛新聞online・ExciteエキサイトNIKKEI COMPASS・BIGLOBEニュース・ニコニコニュース・ReseMom・毎日新聞・JIJI.COM・朝日新聞  2025.1

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  • Molecular Insights Into Chicken Feather Variations Internet

    Mirage.News  2024.10

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  • Discovering the Molecular Mechanisms Behind Chicken Feather Patterns Internet

    AZoLifeSciences  2024.10

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  • Molecular insights into differences in color and shape of male and female chicken feathers Internet

    EUREKALERT !  2024.10

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  • 岡山大学の研究が解明したニワトリ羽の性差の謎とは Internet

    サードニュース  2024.9

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  • 【岡山大学】若冲が極彩色に描いた鶏の羽の性差:その謎を科学が解明 ~エストロゲンがメスの羽を形作る仕組み~ Internet

    山陽新聞/@niftyニュース/毎日新聞/Rakuten Infoseek/Biglobeニュース/Mapion/NIKKEI COMPASS/AGORA/日本農業新聞/アンドラ  2024.9

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  • Research provides molecular insights into sexual dimorphism of chicken feathers Internet

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