Updated on 2023/12/20

写真a

 
ALI SAMSON
 
Organization
Research Institute for Interdisciplinary Science Special-Appointment Assistant Professor
Position
Special-Appointment Assistant Professor
External link

Degree

  • Doctor of Philosophy ( 2019.12 )

  • Master of Science ( 2013.12 )

  • Bachelor of Science (Hons) ( 2011.11 )

  • PhD ( 2019.12   National University of Singapore )

Research Interests

  • Medicinal plants (Pharmacology)

  • Cryo Electron Microscopy

  • Structural biology

  • Biochemistry

Research Areas

  • Life Science / Structural biochemistry  / Biochemistry, structural biology

Education

  • National university of Singapore   Department of Pharmacology   PhD, Biochemistry

    2015.7 - 2019.12

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    Country： Singapore

  • University of Leeds   Biological Sciences   Infection and immunity

    2012.9 - 2013.12

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    Country： United Kingdom

  • University of Ghana   Department of Biochemistry, Cell and Molecular Biology   Biochemistry

    2007.8 - 2011.11

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    Country： Ghana

  • National university of Singapore   Department of Pharmacology   Biochmemistry, structural biology

    2015.8 - 2019.12

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    Country： Singapore

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  • University of Leeds, UK   Faculty of Science   Biological sciences, Infection and Immunity

    2012.9 - 2013.12

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    Notes： Infection and Immunity

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  • University of Ghana   Faculty of Science   Biochemistry, Cell and Molecular Biology

    2007.8 - 2011.5

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Research History

  • Okayama University   Research Institute for Interdisciplinary Science (RIIS)   Assistant Professor   Researcher

    2020.2

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    Country：Japan

  • Okayama University   Research Institute for Interdisciplinary Science (RIIS)   Technical Support Staff   Researcher

    2019.10 - 2020.1

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    Country：Japan

  • Okayama University   Research Institute for Interdisciplinary Science (RIIS)   Researcher   Researcher

    2018.10 - 2019.9

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    Country：Japan

 

Papers

  • Structure and dynamics of Odinarchaeota tubulin and the implications for eukaryotic microtubule evolution

    Caner Akıl, Samson Ali, Linh T. Tran, Jérémie Gaillard, Wenfei Li, Kenichi Hayashida, Mika Hirose, Takayuki Kato, Atsunori Oshima, Kosuke Fujishima, Laurent Blanchoin, Akihiro Narita, Robert C. Robinson

    Science Advances   8 ( 12 )   2022.3

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：American Association for the Advancement of Science (AAAS)  

    Tubulins are critical for the internal organization of eukaryotic cells, and understanding their emergence is an important question in eukaryogenesis. Asgard archaea are the closest known prokaryotic relatives to eukaryotes. Here, we elucidated the apo and nucleotide-bound x-ray structures of an Asgard tubulin from hydrothermal living Odinarchaeota (OdinTubulin). The guanosine 5′-triphosphate (GTP)–bound structure resembles a microtubule protofilament, with GTP bound between subunits, coordinating the “+” end subunit through a network of water molecules and unexpectedly by two cations. A water molecule is located suitable for GTP hydrolysis. Time course crystallography and electron microscopy revealed conformational changes on GTP hydrolysis. OdinTubulin forms tubules at high temperatures, with short curved protofilaments coiling around the tubule circumference, more similar to FtsZ, rather than running parallel to its length, as in microtubules. Thus, OdinTubulin represents an evolutionary stage intermediate between prokaryotic FtsZ and eukaryotic microtubule-forming tubulins.

    DOI： 10.1126/sciadv.abm2225

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  • Structure of a Minimal α-Carboxysome-Derived Shell and Its Utility in Enzyme Stabilization Reviewed International coauthorship

    Tan, Yong Quan, Samson Ali, Bo Xue, Wei Zhe Teo, Lay Hiang Ling, Maybelle Kho Go, Hong Lv, Robert C. Robinson, Akihiro Narita, and Wen Shan Yew

    Biomacromolecules   22 ( no. 10 )   4095 - 4109   2021.8

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acs.biomac

    Other Link： https://doi.org/10.1021/acs.biomac.1c00533

  • Structure of a Minimal α-Carboxysome-Derived Shell and Its Utility in Enzyme Stabilization

    Yong Quan Tan, Samson Ali, Bo Xue, Wei Zhe Teo, Lay Hiang Ling, Maybelle Kho Go, Hong Lv, Robert C. Robinson, Akihiro Narita, Wen Shan Yew

    Biomacromolecules   22 ( 10 )   4095 - 4109   2021.8

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acs.biomac.1c00533

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